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FAM107B Gene

protein-coding GIFtS: 41

GC10M014601

family with sequence similarity 107, member B
(Previous name: chromosome 10 open reading frame 45 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C10orf45)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C10orf45 ^², ³
FLJ45505 ^¹, ²
MGC11034 ^¹, ²
MGC90261 ^²

Descriptions
chromosome 10 open reading frame 45 ^¹
family with sequence similarity 107, member B ^²
hypothetical protein LOC83641 ^²

External Ids
HGNC: 23726¹
Entrez Gene: 83641²
UniProtKB: Q9H098³
Ensembl: ENSG00000065809⁷

Search outside databases for aliases for FAM107B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM107B gene

Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p14

FAM107B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M014601: (about GC identifiers)

Start:	14,600,562 bp from pter
End:	14,856,902 bp from pter
Size:	256,341 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F107B_HUMAN, Q9H098 (See protein sequence)

Recommended Name: Protein FAM107B

Size: 131 amino acids; 15558 Da

Secondary accessions: A8K1P4 Q5T9K7 Q5T9K8 Q6ZSI4

Alternative splicing: 2 isoforms: Q9H098-1 Q9H098-2

REFSEQ proteins: NP_113641.2

ENSEMBL proteins:

ENSP00000181796 ENSP00000367719 ENSP00000367718 ENSP00000367722 ENSP00000367726 ENSP00000367728

ENSP00000367723 ENSP00000367731

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (FAM107B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for FAM107B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM107B

Assays for FAM107B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H098

ProtoNet protein and cluster: Q9H098

UniProtKB/Swiss-Prot: F107B_HUMAN, Q9H098

Similarity: Belongs to the FAM107 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM107B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031453

Applied Biosystems Silencer® siRNAs for FAM107B

Sigma-Aldrich siRNA for FAM107B

Sigma-Aldrich shRNA for FAM107B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM107B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_031453
Myc/DDK tagged cDNA clone in CMV expression vector: NM_031453
untagged cDNA clones in CMV expression vector (see all 2): NM_031453

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_031453

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM107B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM107B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031453

Sigma-Aldrich siRNA for FAM107B

Sigma-Aldrich shRNA for FAM107B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_031453

REFSEQ mRNAs for FAM107B gene:

NM_031453.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_031453

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031453
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_031453
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_031453

Additional cDNA sequence:

AK024648.1 AK074275.1 AK123138.1 AK127413.1 AK289959.1 AL136885.1 BC004872.2 BC064407.1

BC072452.1 BC144707.1 CR533466.1 CR610285.1 CR614450.1 CR620856.1 CR622977.1

24/26 DOTS entries (see all 26 ):

DT.101971582 DT.418374 DT.100811911 DT.101967715 DT.95246385 DT.91698247 DT.95162228 DT.75145968

DT.121270405 DT.121270445 DT.121270406 DT.121270439 DT.91918113 DT.101971054 DT.100811906 DT.75158246

DT.100811914 DT.100811915 DT.121270429 DT.121270438 DT.75112888 DT.95222984 DT.95307695 DT.95324077

24/342 AceView cDNA sequences (see all 342 ):

AA911166 AL120453 AI804440 AI216453 BM792437 AI242360 AI276201 CB112674

AI342573 AA453853 N39351 AI801534 BE048331 BQ081984 BU628854 AA431133

AI005063 AA778195 CR614450 BQ026936 N52764 CR533466 BF793624 BC072452

highest scoring ESTs for FAM107B:

AA027237 AA027238 AA081075 AA081076 AA082303 AA082307 AA234904 AA235057 AA253344 AA295680

Unigene Cluster for FAM107B:

Family with sequence similarity 107, member B

Hs.446315 [show with all ESTs]

Unigene Representative Sequence: AK127413

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM107B

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:									-				-
SP2:					-		-		-		-		-
SP3:									-		-		-
SP4:
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for FAM107B

8 Ensembl transcripts including schematic representations:

ENST00000181796 ENST00000378458 ENST00000378457 ENST00000378461 ENST00000378465 ENST00000378467

ENST00000378462 ENST00000378470

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM107B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM107B

¹ / ² / ³

5 probe-sets matching FAM107B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48788_at²^{, 3}	U95-C	1	0.94	1.00	1.00	1.00	AL043192	0.60	1.00	0.82	1
223059_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC004872	0.60	1.00	0.82	1
223058_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL136885	0.60	1.00	0.82	1
223059_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223058_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FAM107B for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAGTTGATT

SOURCE GeneReport for Unigene cluster: Hs.446315

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM107B gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC607279¹	--	hypothetical protein LOC607279	84.64(n) 81.37(a)	607279 XM_843900.1 XP_848993.1
chimpanzee (Pan troglodytes)	LOC737061¹	--	hypothetical protein LOC737061	99.35(n) 99.35(a)	737061 XM_001143857.1 XP_001143857.1
cow (Bos taurus)	FAM107B¹	--	family with sequence similarity 107, member B	93.13(n) 96.95(a)	535023 NM_001046393.1 NP_001039858.1
rat (Rattus norvegicus)	Fam107b¹	--	family with sequence similarity 107, member B	89.06(n) 99.24(a)	498796 NM_001025034.1 NP_001020205.1
mouse (Mus musculus)	Fam107b^{1, 5}	2⁵	family with sequence similarity 107, member B^{1, 5}	90.59(n)¹ 98.47(a)¹	66540¹ NM_025626.4¹ NP_079902.1¹ AA589595⁵ AA959793⁵ (see all 15)

About this table Species with no ortholog for FAM107B

ENSEMBL Gene Tree for FAM107B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM107B gene

FAM107A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2032 NCBI SNPs in FAM107B are shown (see all 2032 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 627)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs8563^1,2	A,C,F,H,O	14601506(-)	`CTCTAT/CAGTAA`	1	--	ut3¹ ese³		13	MN NA EU EA WA	1292
	rs6602765^1,2	A,C,F,H	14857276(+)	`GATGCT/GGTGTG`	1	--	ng3¹		3	EU EA	298
	rs2768716^1,2	A,C,F,H	14858826(+)	`GGCCCA/GCTAAG`	1	--	ng3¹		8	EU EA WA	786
	rs11259333^1,2	A,C,F,H	14857073(+)	`CATAAT/CAGCGT`	1	--	ng3¹		15	NA EU EA WA	1400
	rs2768714^1,2	A,C,F,H	14858597(+)	`TTCATT/ATATTC`	1	--	ng3¹		4	EU EA WA	418
	rs2768715^1,2	A,C,F,H	14858692(+)	`CTGAGG/TAAGAA`	1	--	ng3¹ trp³		8	EU EA WA	836
	rs3780915^1,2	A,C,F,H	14603103(-)	`ATATTC/TCAGCC`	1	--	ut3¹ ese³		9	EA EU WA	2340
	rs12256790^1,2	A,C,F,H	14858876(+)	`CTAGAA/GTAACA`	1	--	ng3¹		12	EU EA WA NA	1024
	rs7071481^1,2	C,F,H	14858652(+)	`TTCACA/GGTGCA`	1	--	ng3¹		8	EU EA WA	822
	rs12774550^1,2	C,F,H	14602986(+)	`CGTGCG/AGGGCA`	1	--	ut3¹ ese³		8	EU EA WA	788

About this table

HapMap Linkage Disequilibrium images for FAM107B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for FAM107B gene:

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{2, 3, 4} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 83641	HGNC: 23726	AceView: C10orf45	Ensembl:ENSG00000065809	euGenes: HUgn83641
ECgene: FAM107B	H-InvDB: FAM107B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM107B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM107B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM107B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM107B		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM107B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FAM107B)
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for FAM107B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM107B

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FAM107B Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for FAM107B

Summaries
for FAM107B

Genomic Location
for FAM107B

Proteins
for FAM107B

Protein Domains/
Families
for FAM107B

Gene Function
for FAM107B

Pathways & Interactions
for FAM107B

Drugs & Compounds
for FAM107B

Transcripts
for FAM107B

Expression
for FAM107B

Orthologs
for FAM107B

Paralogs
for FAM107B

SNPs/Variants
for FAM107B

Disorders & Mutations
for FAM107B

Medical News
for FAM107B

Publications
for FAM107B

Search for FAM107B

Genome Databases showing FAM107B

Other Databases showing FAM107B

Specialized Databases showing FAM107B

Licensable Technologies
for FAM107B

Services
for FAM107B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM107B Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor FAM107B

Summariesfor FAM107B

Genomic Locationfor FAM107B

Proteinsfor FAM107B

Protein Domains/Familiesfor FAM107B

Gene Functionfor FAM107B

Pathways & Interactionsfor FAM107B

Drugs & Compoundsfor FAM107B

Transcriptsfor FAM107B

Expression for FAM107B

Orthologsfor FAM107B

Paralogsfor FAM107B

SNPs/Variantsfor FAM107B

Disorders & Mutationsfor FAM107B

Medical Newsfor FAM107B

Publicationsfor FAM107B

Search for FAM107B

Genome Databases showing FAM107B

Other Databases showing FAM107B

Specialized Databases showing FAM107B

Licensable Technologiesfor FAM107B

Servicesfor FAM107B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM107B

Summaries
for FAM107B

Genomic Location
for FAM107B

Proteins
for FAM107B

Protein Domains/
Families
for FAM107B

Gene Function
for FAM107B

Pathways & Interactions
for FAM107B

Drugs & Compounds
for FAM107B

Transcripts
for FAM107B

Expression
for FAM107B

Orthologs
for FAM107B

Paralogs
for FAM107B

SNPs/Variants
for FAM107B

Disorders & Mutations
for FAM107B

Medical News
for FAM107B

Publications
for FAM107B

Licensable Technologies
for FAM107B

Services
for FAM107B