FAM107B Gene
protein-coding GIFtS: 46
GCID: GC10M014471 (predicted)
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family with sequence similarity 107, member B(Previous name: chromosome 10 open reading frame 45 )
(Previous symbol: C10orf45)
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Aliases
for FAM107B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 107, Member B1 2 | | C10orf451 2 3 | | FLJ455051 | | MGC110341 | | Chromosome 10 Open Reading Frame 451 | | Protein FAM107B2 |
Export aliases for FAM107B gene to outside databasesPrevious GC identifer: GC10M014601 |
Summaries
for FAM107B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM107B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM107B gene promoter:
SRF Sox5 RREB-1 SRF (504 AA) Ik-3 Arnt MEF-2A FAC1 SRY aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM107B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM107B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p14FAM107B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M014471: view genomic region
(about GC identifiers)
Start:
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14,560,556 bp from pter |
End:
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14,816,896 bp from pter |
Size:
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256,341 bases |
Orientation:
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minus strand |
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Proteins
for FAM107B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F107B_HUMAN, Q9H098 (See
protein sequence)Recommended Name: Protein FAM107B Size: 131 amino acids; 15558 Da
Secondary accessions: A8K1P4 D3DRT2 Q5T9K7 Q5T9K8 Q6ZSI4Alternative splicing: 2 isoforms: Q9H098-1 Q9H098-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM107B: NX_Q9H098
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H098
FAM107B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113641.2
ENSEMBL proteins: ENSP00000367731 ENSP00000181796 ENSP00000418120 ENSP00000367728 ENSP00000420273 ENSP00000367726 ENSP00000367719 ENSP00000417782 ENSP00000367723 ENSP00000418365 ENSP00000367722 ENSP00000418330 ENSP00000419603 ENSP00000420444 ENSP00000413676 ENSP00000420249 ENSP00000418395 ENSP00000417242 ENSP00000420314 ENSP00000397949 ENSP00000417845 ENSP00000419064
Human Recombinant Protein Products:
FAM107B Antibody Products:
Assay Products for FAM107B: |
Protein
Domains /
Families
for FAM107B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM107B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H098ProtoNet protein and cluster: Q9H098 UniProtKB/Swiss-Prot: F107B_HUMAN, Q9H098Similarity: Belongs to the FAM107 family |
Function
for FAM107B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM107B (NM_031453) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM107B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM107B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM107B |
2 GenomeRNAi human phenotypes for FAM107B:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fam107b):
FAM107B for phenotypes About GeneDecksing
|
Pathways & Interactions
for FAM107B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM107B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/72 Interacting proteins for FAM107B (Q9H0982, 3 ENSP000001817964) via UniProtKB, MINT, STRING, and/or I2D (see all 72)About this table
|
Drugs & Compounds
for FAM107B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM107B
Search CenterWatch for drugs/clinical trials and news about FAM107B / F107B
|
Transcripts
for FAM107B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM107B gene: NM_031453.2 Unigene Cluster for FAM107B: Family with sequence similarity 107, member B Hs.446315 [show with all ESTs]Unigene Representative Sequence: AK12741318/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29): ENST00000378470(uc001imx.1 uc009xjg.1 uc001imy.1 uc001imz.1)
ENST00000181796(uc001ina.1 uc010qbu.1) ENST00000468747 ENST00000378467
ENST00000487335 ENST00000378465 ENST00000378458 ENST00000478076 ENST00000378462
ENST00000481209 ENST00000475858 ENST00000378461 ENST00000496330 ENST00000492700
ENST00000479731 ENST00000468492 ENST00000452706 ENST00000489100
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM107B (NM_031453) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM107B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM107B |
Additional cDNA sequence: AK024648.1 AK074275.1 AK123138.1 AK127413.1 AK289959.1 AL136885.1 BC004872.2 BC064407.1 BC072452.1 BC144707.1 CR533466.1 24/25 DOTS entries (see all 25): DT.101971582 DT.418374 DT.100811911 DT.101967715 DT.95246385 DT.91698247 DT.95162228 DT.121270405 DT.121270445 DT.121270406 DT.121270439 DT.75145968 DT.91918113 DT.101971054 DT.100811906 DT.100708000 DT.100811914 DT.100811915 DT.121270429 DT.121270438 DT.75112888 DT.95222984 DT.95307695 DT.95324077 24/342 AceView cDNA sequences (see all 342): AA027238 BQ081984 BP369343 AI342573 N52764 AW580903 N73845 AI276201 AI801534 BM792437 BM463487 CB112674 CB043884 CR620856 BM709087 AI804440 R27914 AA745752 BU074502 CF529990 AI587633 BP350275 AA453853 BX419408
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAM107B About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
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| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM107B
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Expression
for FAM107B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM107B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAGTTGATT
About this image
See FAM107B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM107B
SOURCE GeneReport for Unigene cluster: Hs.446315
SABiosciences Custom PCR Arrays for FAM107B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM107B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM107B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM107B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM107B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM107B |
Orthologs
for FAM107B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM107B gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for FAM107B (if available)
TreeFam Gene Tree for FAM107B (if available) |
Paralogs
for FAM107B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM107B gene
- FAM107A2
2 SIMAP similar genes for FAM107B using alignment to 10 protein entries: F107B_HUMAN (see all proteins):FAM107A TU3A
FAM107B for paralogs About GeneDecksing
|
Genomic Variants
for FAM107B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM107B (14560556 - 14810556 bp, first 250kb of FAM107B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FAM107B
3 CNVs: 1218 47859 8640
1 Indel: 41652 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM107B |
|
Disorders
/ Diseases
for FAM107B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM107B for disorders About GeneDecksing
1  disease for FAM107B: About MalaCardsalzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: FAM107B (5 documents)
Export disorders for FAM107B gene to outside databases
|
Publications
for FAM107B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM107B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FAM107B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
|
External Searches for FAM107B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM107B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM107B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM107B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM107B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM107B gene:
Search GeneIP for patents involving FAM107B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM107B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM107B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM107B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM107B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM107B | | OriGene 3'-UTR Clone for FAM107B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM107B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM107B | | OriGene Custom Protein Services for FAM107B | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM107B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM107B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM107B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM107B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM107B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM107B |
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| | | | Search Tocris compounds for FAM107B |
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 | | | FAM107B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM107B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM107B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM107B |
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