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Aliases for FAM107B Gene

Aliases for FAM107B Gene

  • Family With Sequence Similarity 107 Member B 2 3 5
  • Family With Sequence Similarity 107, Member B 2 3
  • C10orf45 3 4
  • Chromosome 10 Open Reading Frame 45 2

External Ids for FAM107B Gene

Previous HGNC Symbols for FAM107B Gene

  • C10orf45

Previous GeneCards Identifiers for FAM107B Gene

  • GC10M014601

Summaries for FAM107B Gene

GeneCards Summary for FAM107B Gene

FAM107B (Family With Sequence Similarity 107 Member B) is a Protein Coding gene. An important paralog of this gene is FAM107A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM107B Gene

Genomics for FAM107B Gene

Regulatory Elements for FAM107B Gene

Genomic Location for FAM107B Gene

14,518,557 bp from pter
14,774,897 bp from pter
256,341 bases
Minus strand

Genomic View for FAM107B Gene

Genes around FAM107B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM107B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM107B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM107B Gene

Proteins for FAM107B Gene

  • Protein details for FAM107B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM107B
    Protein Accession:
    Secondary Accessions:
    • A8K1P4
    • D3DRT2
    • Q5T9K7
    • Q5T9K8
    • Q6ZSI4

    Protein attributes for FAM107B Gene

    131 amino acids
    Molecular mass:
    15558 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM107B Gene


neXtProt entry for FAM107B Gene

Proteomics data for FAM107B Gene at MOPED

Post-translational modifications for FAM107B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM107B Gene

Domains & Families for FAM107B Gene

Protein Domains for FAM107B Gene


Suggested Antigen Peptide Sequences for FAM107B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM107 family.
  • Belongs to the FAM107 family.
genes like me logo Genes that share domains with FAM107B: view

No data available for Gene Families for FAM107B Gene

Function for FAM107B Gene

genes like me logo Genes that share phenotypes with FAM107B: view

Animal Models for FAM107B Gene

MGI Knock Outs for FAM107B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM107B Gene

Localization for FAM107B Gene

Subcellular locations from

Jensen Localization Image for FAM107B Gene COMPARTMENTS Subcellular localization image for FAM107B gene
Compartment Confidence
mitochondrion 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM107B Gene

Pathways & Interactions for FAM107B Gene

SuperPathways for FAM107B Gene

No Data Available

Interacting Proteins for FAM107B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000181796 Q9H098-F107B_HUMAN for FAM107B Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for FAM107B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM107B Gene

Drugs & Compounds for FAM107B Gene

No Compound Related Data Available

Transcripts for FAM107B Gene

Unigene Clusters for FAM107B Gene

Family with sequence similarity 107, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM107B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - - - -
SP3: - - -
SP5: - -

Relevant External Links for FAM107B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM107B Gene

mRNA expression in normal human tissues for FAM107B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM107B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for FAM107B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), NK cells (8.5), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM107B Gene

SOURCE GeneReport for Unigene cluster for FAM107B Gene Hs.446315

genes like me logo Genes that share expression patterns with FAM107B: view

Protein tissue co-expression partners for FAM107B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM107B Gene

Orthologs for FAM107B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM107B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM107B 36
  • 99 (a)
LOC737061 35
  • 99.35 (n)
  • 99.35 (a)
(Ornithorhynchus anatinus)
Mammalia FAM107B 36
  • 77 (a)
(Mus musculus)
Mammalia Fam107b 36
  • 98 (a)
Fam107b 16
Fam107b 35
  • 90.59 (n)
  • 98.47 (a)
(Monodelphis domestica)
Mammalia FAM107B 36
  • 69 (a)
(Canis familiaris)
Mammalia FAM107B 36
  • 81 (a)
FAM107B 35
  • 84.64 (n)
  • 81.37 (a)
(Bos Taurus)
Mammalia FAM107B 36
  • 98 (a)
FAM107B 35
  • 93.13 (n)
  • 96.95 (a)
(Rattus norvegicus)
Mammalia Fam107b 35
  • 89.06 (n)
  • 99.24 (a)
(Gallus gallus)
Aves FAM107B 36
  • 80 (a)
(Anolis carolinensis)
Reptilia FAM107B 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam107b 35
  • 73.54 (n)
  • 73.28 (a)
(Danio rerio)
Actinopterygii fam107b 36
  • 64 (a)
zgc56216 35
fam107b 35
  • 73.33 (n)
  • 80 (a)
Species with no ortholog for FAM107B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM107B Gene

Gene Tree for FAM107B (if available)
Gene Tree for FAM107B (if available)

Paralogs for FAM107B Gene

Paralogs for FAM107B Gene

genes like me logo Genes that share paralogs with FAM107B: view

Variants for FAM107B Gene

Sequence variations from dbSNP and Humsavar for FAM107B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs8563 -- 14,519,501(-) CTCTA(C/T)AGTAA utr-variant-3-prime
rs365487 -- 14,697,601(-) TCCTA(A/G)AGGTA intron-variant
rs368480 -- 14,749,468(-) TTCTA(A/G)CTTTG intron-variant
rs368886 -- 14,772,908(-) GACCC(A/C)CCTTA intron-variant, downstream-variant-500B
rs371309 -- 14,757,161(-) TAttt(A/T)aactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM107B Gene

Variant ID Type Subtype PubMed ID
esv34151 CNV Loss 18971310
nsv528028 CNV Gain 19592680
nsv831791 CNV Gain 17160897
nsv437659 CNV Loss 16327808
nsv5877 CNV Insertion 18451855
esv3533 CNV Deletion 18987735
esv1195185 CNV Insertion 17803354
esv1292577 CNV Insertion 17803354
esv2750884 CNV Gain 17911159
esv2733439 CNV Deletion 23290073
nsv517896 CNV Gain 19592680
esv2676128 CNV Deletion 23128226
esv2658515 CNV Deletion 23128226
nsv5888 CNV Loss 18451855
nsv471664 CNV Gain+Loss 15918152
nsv894889 CNV Gain 21882294
nsv894890 CNV Gain 21882294
esv2733450 CNV Deletion 23290073
esv1960476 CNV Deletion 18987734
esv1027578 CNV Deletion 17803354
esv2733461 CNV Deletion 23290073
esv2733473 CNV Deletion 23290073

Variation tolerance for FAM107B Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM107B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM107B Gene

Disorders for FAM107B Gene

Relevant External Links for FAM107B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM107B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM107B Gene

Publications for FAM107B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. (PMID: 25293881) Patel Y.M. … Murphy S.E. (Cancer Epidemiol. Biomarkers Prev. 2015) 3
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  4. Loss of HITS (FAM107B) expression in cancers of multiple organs: tissue microarray analysis. (PMID: 22825356) Nakajima H. … Motoo Y. (Int. J. Oncol. 2012) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for FAM107B Gene

Sources for FAM107B Gene

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