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Aliases for FAM107B Gene

Aliases for FAM107B Gene

  • Family With Sequence Similarity 107 Member B 2 3 5
  • Heat Shock-Inducible Tumor Small Protein 2 3
  • C10orf45 3 4
  • Family With Sequence Similarity 107, Member B 2
  • Chromosome 10 Open Reading Frame 45 2
  • FAM107B/CDNF Fusion 3
  • Protein FAM107B 3
  • HITS 3

External Ids for FAM107B Gene

Previous HGNC Symbols for FAM107B Gene

  • C10orf45

Previous GeneCards Identifiers for FAM107B Gene

  • GC10M014601

Summaries for FAM107B Gene

GeneCards Summary for FAM107B Gene

FAM107B (Family With Sequence Similarity 107 Member B) is a Protein Coding gene. An important paralog of this gene is FAM107A.

Additional gene information for FAM107B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM107B Gene

Genomics for FAM107B Gene

GeneHancer (GH) Regulatory Elements for FAM107B Gene

Promoters and enhancers for FAM107B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I014601 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.6 +171.3 171296 4.9 HDGF PKNOX1 SMAD1 SIN3A FEZF1 YBX1 ZNF2 IRF4 ZNF213 ZNF302 FAM107B LOC105376429 CDNF HSPA14 C10orf111 GC10M014524
GH10I014558 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.6 +208.4 208361 16.3 CLOCK FOXA2 ZNF133 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ETS1 YY1 FAM107B HSPA14 CDNF LOC105376429 DCLRE1C GC10M014524
GH10I014774 Promoter 0.5 EPDnew 550.8 0.0 -12 0.1 FAM107B HSPA14
GH10I014647 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 33.7 +126.3 126256 3.1 HDGF PKNOX1 BMI1 BATF IRF4 SCRT2 ZNF207 ZNF143 ATF7 RCOR1 FAM107B C10orf111 HSPA14 CDNF DCLRE1C RPP38 LOC105376429 GC10M014524
GH10I014651 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 30 +120.6 120579 5.4 PKNOX1 NEUROD1 SIN3A FEZF1 ZNF2 IRF4 BRCA1 GLIS2 ZNF213 E2F8 LOC105376429 LOC105376428 FAM107B CDNF HSPA14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM107B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM107B gene promoter:

Genomic Locations for FAM107B Gene

Genomic Locations for FAM107B Gene
chr10:14,518,557-14,774,897
(GRCh38/hg38)
Size:
256,341 bases
Orientation:
Minus strand
chr10:14,560,556-14,816,896
(GRCh37/hg19)

Genomic View for FAM107B Gene

Genes around FAM107B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM107B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM107B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM107B Gene

Proteins for FAM107B Gene

  • Protein details for FAM107B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H098-F107B_HUMAN
    Recommended name:
    Protein FAM107B
    Protein Accession:
    Q9H098
    Secondary Accessions:
    • A8K1P4
    • D3DRT2
    • Q5T9K7
    • Q5T9K8
    • Q6ZSI4

    Protein attributes for FAM107B Gene

    Size:
    131 amino acids
    Molecular mass:
    15558 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM107B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM107B Gene

Post-translational modifications for FAM107B Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM107B Gene

Domains & Families for FAM107B Gene

Gene Families for FAM107B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM107B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM107B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H098

UniProtKB/Swiss-Prot:

F107B_HUMAN :
  • Belongs to the FAM107 family.
Family:
  • Belongs to the FAM107 family.
genes like me logo Genes that share domains with FAM107B: view

Function for FAM107B Gene

Phenotypes From GWAS Catalog for FAM107B Gene

genes like me logo Genes that share phenotypes with FAM107B: view

Animal Models for FAM107B Gene

MGI Knock Outs for FAM107B:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM107B Gene

Localization for FAM107B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM107B gene
Compartment Confidence
mitochondrion 3
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM107B Gene

Pathways & Interactions for FAM107B Gene

SuperPathways for FAM107B Gene

No Data Available

Interacting Proteins for FAM107B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000181796%0d%0a9606.ENSP00000220597%0d%0a
Selected Interacting proteins: Q9H098-F107B_HUMAN ENSP00000181796 for FAM107B Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM107B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM107B Gene

Drugs & Compounds for FAM107B Gene

No Compound Related Data Available

Transcripts for FAM107B Gene

Unigene Clusters for FAM107B Gene

Family with sequence similarity 107, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM107B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for FAM107B Gene

GeneLoc Exon Structure for
FAM107B
ECgene alternative splicing isoforms for
FAM107B

Expression for FAM107B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM107B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM107B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for FAM107B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), NK cells (8.5), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM107B Gene



Protein tissue co-expression partners for FAM107B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM107B Gene:

FAM107B

SOURCE GeneReport for Unigene cluster for FAM107B Gene:

Hs.446315

Evidence on tissue expression from TISSUES for FAM107B Gene

  • Nervous system(4.6)
  • Stomach(2.3)
  • Kidney(2.2)
  • Liver(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with FAM107B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM107B Gene

Orthologs for FAM107B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM107B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC737061 33
  • 99.35 (n)
FAM107B 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM107B 33 34
  • 93.13 (n)
mouse
(Mus musculus)
Mammalia Fam107b 33 16 34
  • 90.59 (n)
rat
(Rattus norvegicus)
Mammalia Fam107b 33
  • 89.06 (n)
dog
(Canis familiaris)
Mammalia FAM107B 33 34
  • 84.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM107B 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM107B 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM107B 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM107B 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam107b 33
  • 73.54 (n)
zebrafish
(Danio rerio)
Actinopterygii fam107b 33 34
  • 73.33 (n)
zgc56216 33
Species where no ortholog for FAM107B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM107B Gene

ENSEMBL:
Gene Tree for FAM107B (if available)
TreeFam:
Gene Tree for FAM107B (if available)

Paralogs for FAM107B Gene

Paralogs for FAM107B Gene

genes like me logo Genes that share paralogs with FAM107B: view

Variants for FAM107B Gene

Sequence variations from dbSNP and Humsavar for FAM107B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000024003 -- 14,595,873(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000027564 -- 14,619,222(-) CCC/CC genic_upstream_transcript_variant, intron_variant
rs1000048209 -- 14,519,670(-) C/T 3_prime_UTR_variant
rs1000051542 -- 14,636,929(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000051841 -- 14,665,125(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM107B Gene

Variant ID Type Subtype PubMed ID
esv1027578 CNV deletion 17803354
esv1195185 CNV insertion 17803354
esv1292577 CNV insertion 17803354
esv1960476 CNV deletion 18987734
esv2658515 CNV deletion 23128226
esv2676128 CNV deletion 23128226
esv2733439 CNV deletion 23290073
esv2733450 CNV deletion 23290073
esv2733461 CNV deletion 23290073
esv2733473 CNV deletion 23290073
esv2750884 CNV gain 17911159
esv34151 CNV loss 18971310
esv3533 CNV loss 18987735
esv3622427 CNV loss 21293372
esv3622428 CNV loss 21293372
esv3622429 CNV loss 21293372
nsv1043133 CNV loss 25217958
nsv1068284 CNV deletion 25765185
nsv1068285 CNV deletion 25765185
nsv1113254 CNV deletion 24896259
nsv1113255 CNV deletion 24896259
nsv1118160 CNV deletion 24896259
nsv1124398 CNV deletion 24896259
nsv1129490 CNV tandem duplication 24896259
nsv1135769 CNV deletion 24896259
nsv437659 CNV loss 16327808
nsv471664 CNV gain+loss 15918152
nsv517896 CNV gain 19592680
nsv528028 CNV gain 19592680
nsv549997 CNV gain 21841781
nsv549998 CNV gain 21841781
nsv5877 CNV insertion 18451855
nsv5888 CNV deletion 18451855
nsv831791 CNV gain 17160897
nsv947744 CNV duplication 23825009
nsv958571 CNV deletion 24416366

Variation tolerance for FAM107B Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM107B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM107B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM107B Gene

Disorders for FAM107B Gene

Additional Disease Information for FAM107B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM107B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM107B Gene

Publications for FAM107B Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for FAM107B Gene

Sources for FAM107B Gene

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