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Aliases for FAM107A Gene

Aliases for FAM107A Gene

  • Family With Sequence Similarity 107, Member A 2 3
  • DRR1 3 4 6
  • TU3A 3 4 6
  • Down-Regulated In Renal Cell Carcinoma 1 3 4
  • Protein FAM107A 3
  • Protein TU3A 4

External Ids for FAM107A Gene

Summaries for FAM107A Gene

GeneCards Summary for FAM107A Gene

FAM107A (Family With Sequence Similarity 107, Member A) is a Protein Coding gene. Diseases associated with FAM107A include renal cell carcinoma. An important paralog of this gene is FAM107B.

UniProtKB/Swiss-Prot for FAM107A Gene

  • When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.

Gene Wiki entry for FAM107A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM107A Gene

Genomics for FAM107A Gene

Genomic Location for FAM107A Gene

Start:
58,564,112 bp from pter
End:
58,627,610 bp from pter
Size:
63,499 bases
Orientation:
Minus strand

Genomic View for FAM107A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM107A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM107A Gene

Regulatory Elements for FAM107A Gene

Proteins for FAM107A Gene

  • Protein details for FAM107A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95990-F107A_HUMAN
    Recommended name:
    Protein FAM107A
    Protein Accession:
    O95990
    Secondary Accessions:
    • B3KNQ4
    • B7ZAY5
    • J3KR61
    • Q96NH4

    Protein attributes for FAM107A Gene

    Size:
    144 amino acids
    Molecular mass:
    17455 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM107A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM107A Gene

Proteomics data for FAM107A Gene at MOPED

Post-translational modifications for FAM107A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM107A Gene

Domains for FAM107A Gene

Protein Domains for FAM107A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F107A_HUMAN
Family:
  • Belongs to the FAM107 family.:
    • O95990
genes like me logo Genes that share domains with FAM107A: view

No data available for Gene Families for FAM107A Gene

Function for FAM107A Gene

Molecular function for FAM107A Gene

UniProtKB/Swiss-Prot Function: When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.

Gene Ontology (GO) - Molecular Function for FAM107A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM107A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM107A Gene

Localization for FAM107A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM107A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM107A Gene COMPARTMENTS Subcellular localization image for FAM107A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM107A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10564580
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with FAM107A: view

Pathways for FAM107A Gene

SuperPathways for FAM107A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM107A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 10564580
genes like me logo Genes that share ontologies with FAM107A: view

No data available for Pathways by source for FAM107A Gene

Transcripts for FAM107A Gene

Unigene Clusters for FAM107A Gene

Family with sequence similarity 107, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM107A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a ·
SP1: - -
SP2: - - - - - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: -
SP12: - - - - - - - - - - - - -
SP13:
SP14: - - - - - - - - -

ExUns: 12b · 12c ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14:

Relevant External Links for FAM107A Gene

GeneLoc Exon Structure for
FAM107A
ECgene alternative splicing isoforms for
FAM107A

Expression for FAM107A Gene

mRNA expression in normal human tissues for FAM107A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM107A Gene

This gene is overexpressed in Brain - Amygdala (5.8), Brain - Hippocampus (4.7), and Brain - Spinal cord (cervical c-1) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM107A Gene

SOURCE GeneReport for Unigene cluster for FAM107A Gene Hs.506357

mRNA Expression by UniProt/SwissProt for FAM107A Gene

O95990-F107A_HUMAN
Tissue specificity: Widely expressed in normal tissues. Expression is reduced or absent in a number of cancer cell lines.
genes like me logo Genes that share expressions with FAM107A: view

Orthologs for FAM107A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM107A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM107A 36
  • 99.31 (n)
  • 99.31 (a)
FAM107A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM107A 36
  • 92.36 (n)
  • 95.83 (a)
MGC143103 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM107A 36
  • 90.48 (n)
  • 95.92 (a)
FAM107A 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam107a 36
  • 86.34 (n)
  • 90.97 (a)
Fam107a 16
Fam107a 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM107A 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam107a 36
  • 87.04 (n)
  • 91.67 (a)
chicken
(Gallus gallus)
Aves FAM107A 36
  • 68.41 (n)
  • 65.12 (a)
FAM107A 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM107A 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9700 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fam107a 36
  • 72.77 (n)
  • 72.54 (a)
zebrafish
(Danio rerio)
Actinopterygii FAM107A 37
  • 42 (a)
OneToOne
LOC794256 36
  • 58.59 (n)
  • 54.55 (a)
Species with no ortholog for FAM107A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM107A Gene

ENSEMBL:
Gene Tree for FAM107A (if available)
TreeFam:
Gene Tree for FAM107A (if available)

Paralogs for FAM107A Gene

Paralogs for FAM107A Gene

Selected SIMAP similar genes for FAM107A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM107A: view

Variants for FAM107A Gene

Sequence variations from dbSNP and Humsavar for FAM107A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13673 -- 58,565,486(-) GTGAC(C/T)ACACT utr-variant-3-prime
rs715852 -- 58,608,544(-) TAACT(A/G)TACCA intron-variant
rs717323 -- 58,608,691(+) GACCC(A/C)CTTGG intron-variant
rs728969 -- 58,623,765(+) CTCCA(C/T)GTCTC intron-variant
rs748025 -- 58,629,323(-) ATCAC(A/G)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM107A Gene

Variant ID Type Subtype PubMed ID
nsv876831 CNV Gain 21882294
nsv3839 CNV Loss 18451855
nsv876832 CNV Loss 21882294
nsv470605 CNV Gain 18288195
nsv524472 CNV Gain 19592680

Relevant External Links for FAM107A Gene

HapMap Linkage Disequilibrium report
FAM107A

Disorders for FAM107A Gene

(1) MalaCards Diseases for FAM107A Gene

Search for FAM107A Gene in MalaCards »

(1) University of Copenhagen DISEASES for FAM107A Gene

Relevant External Links for FAM107A

Genetic Association Database (GAD)
FAM107A
genes like me logo Genes that share disorders with FAM107A: view

No data available for UniProtKB/Swiss-Prot for FAM107A Gene

Publications for FAM107A Gene

  1. Loss of expression of the DRR1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. (PMID: 10564580) Wang L. … Smith D.I. (Genes Chromosomes Cancer 2000) 2 3 4
  2. Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3->p14.2 in renal cell carcinoma. (PMID: 10702698) Yamato T. … Horii A. (Cytogenet. Cell Genet. 1999) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FAM107A Gene

Sources for FAM107A Gene

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