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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM107A Gene

protein-coding   GIFtS: 47
GCID: GC03M058526

family with sequence similarity 107, member A

 Explore 11 diseases affiliated with
FAM107A via our new
 Human Malady Compendium 
Biological research products
for FAM107A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 107, Member A1 2     Family With Sequence Similarity 107 Member A Transcript2
DRR11 2 3 5     Protein FAM107A2
TU3A1 2 3 5     Protein TU3A3
Down-Regulated In Renal Cell Carcinoma 12 3     

External Ids:    HGNC: 308271   Entrez Gene: 111702   Ensembl: ENSG000001683097   OMIM: 6082955   UniProtKB: O959903   

Export aliases for FAM107A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
Function: When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in
tumor development

Gene Wiki entry for FAM107A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM107A gene promoter:
         Oct-B1   AML1a   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   Evi-1   Pax-2b   HSF2   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM107A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM107A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM107A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p14.2

FAM107A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM107A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M058526:  view genomic region     (about GC identifiers)

Start:
58,549,844 bp from pter      End:
58,613,337 bp from pter
Size:
63,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 (See protein sequence)
Recommended Name: Protein FAM107A  
Size: 144 amino acids; 17455 Da
Subcellular location: Nucleus
Secondary accessions: Q96NH4
Alternative splicing: 2 isoforms:  O95990-1   O95990-2   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM107A: NX_O95990

FAM107A Protein expression data from MOPED and PaxDb:    About this image 
FAM107A Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001070246.1  NP_009108.1  

ENSEMBL proteins: 
 ENSP00000354270   ENSP00000377991   ENSP00000419529   ENSP00000419124   ENSP00000400858  
 ENSP00000418038  

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Uscn Proteins for FAM107A

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA10564580

FAM107A for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for FAM107A


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM107A for domains           About GeneDecksing

1 InterPro domain/family:
 IPR009533 DUF1151

Graphical View of Domain Structure for InterPro Entry O95990

ProtoNet protein and cluster: O95990

UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
Similarity: Belongs to the FAM107 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: F107A_HUMAN, O95990
Function: When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in
tumor development

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
FAM107A for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM107A 

miRNA
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hsa-miR-194* hsa-miR-647 hsa-miR-34c-5p hsa-miR-516b hsa-miR-449b hsa-miR-449a hsa-miR-3921 hsa-miR-182
SwitchGear 3'UTR luciferase reporter plasmidFAM107A 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM107A 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM107A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM107A

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/30 Interacting proteins for FAM107A (O959901, 2, 3 ENSP000003542704) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
InteractantInteraction Details
GeneCardExternal ID(s)
CCDC85BQ158342, 3, ENSP000003116954MINT-68129 I2D: score=5 STRING: ENSP00000311695
KRT15P190122, 3, ENSP000002540434MINT-67827 I2D: score=5 STRING: ENSP00000254043
NINLQ9Y2I62, 3, ENSP000002788864MINT-68263 I2D: score=5 STRING: ENSP00000278886
TRIM37O949722, 3, ENSP000002622944MINT-66452 I2D: score=5 STRING: ENSP00000262294
EFEMP2O959672, 3, ENSP000003099534MINT-66339 I2D: score=4 STRING: ENSP00000309953
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth IDA10564580

FAM107A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM107A
Search CenterWatch for drugs/clinical trials and news about FAM107A / F107A 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM107A gene (2 alternative transcripts): 
NM_001076778.1  NM_007177.2  

Unigene Cluster for FAM107A:

Family with sequence similarity 107, member A
Hs.506357  [show with all ESTs]
Unigene Representative Sequence: AF089854
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360997(uc003dkn.3 uc010hnm.3 uc003dko.3) ENST00000394481(uc003dkm.3)
ENST00000464064(uc003dkp.1) ENST00000474531 ENST00000447756 ENST00000465970
ENST00000497310

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM107A
8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM107A (see all 14):
hsa-miR-194* hsa-miR-647 hsa-miR-34c-5p hsa-miR-516b hsa-miR-449b hsa-miR-449a hsa-miR-3921 hsa-miR-182
SwitchGear 3'UTR luciferase reporter plasmidFAM107A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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OriGene shRNA RFP: FAM107A
OriGene siRNA: FAM107A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM107A
Sirion Biotech Custom design and validation of potent shRNA sequences against FAM107A 
Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM107A (see all 4)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM107A 
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Additional cDNA sequence: 

AB023811.1 AF035283.1 AF089853.1 AF089854.1 AK054720.1 AK055443.1 AK128791.1 AK298001.1 
AK316450.1 AL050264.1 BC010561.1 BC093012.1 CR457133.1 EU569833.1 

24/25 DOTS entries (see all 25):

DT.100792271  DT.100792274  DT.40252339  DT.100792275  DT.95363147  DT.99988736  DT.40211893  DT.95363151 
DT.95363145  DT.100775775  DT.120887427  DT.120887491  DT.120887403  DT.120887399  DT.120887419  DT.120887493 
DT.95324091  DT.100792277  DT.120887379  DT.120887390  DT.120887452  DT.95187780  DT.97788160  DT.97863455 

24/546 AceView cDNA sequences (see all 546):

BI912898 AI291190 AA322994 T34903 CR617615 CR607139 BP346541 AI862302 
BP346624 BP346562 BP348340 AW205038 CR610702 BG152903 T31141 BQ637374 
BP347703 F11836 BU731312 CD677908 AW161103 CA391608 BE255917 BP347550 

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FAM107A (see all 14)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a ·
SP1:                                                                                                                                -                 -         
SP2:                          -           -     -     -     -     -     -     -                                                     -                           
SP3:                                                                                                                                -                           
SP4:                                                                          -                                                     -                 -         
SP5:              -     -     -           -     -     -     -     -     -     -                                                                                 

ExUns: 12b · 12c ^ 13
SP1:                  
SP2:                  
SP3:                  
SP4:                  
SP5:                  


ECgene alternative splicing isoforms for FAM107A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM107A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAAAAGGC
FAM107A Expression
About this image

FAM107A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
BrainHypothalamusBrain
Head MesenchymeFrontonasal ProcessHead Mesenchyme
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See FAM107A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM107A

SOURCE GeneReport for Unigene cluster: Hs.506357

UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
Tissue specificity: Widely expressed in normal tissues. Expression is reduced or absent in a number of cancer cell
lines

    SABiosciences Custom PCR Arrays for FAM107A
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM107A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM107A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FAM107A gene from 5/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves FAM107A1 family with sequence similarity 107, member A 73(n)
72.54(a)
  427591  XM_425164.2  XP_425164.2 
lizard
(Anolis carolinensis)
Reptilia FAM107A6
--
73(a)
1 ↔ 1
2(187105505-187120824)
African clawed frog
(Xenopus laevis)
Amphibia Xl.97002 Xenopus laevis transcribed sequence with moderate similarity more 73.2(n)    BG554253.1 
zebrafish
(Danio rerio)
Actinopterygii LOC7942561 protein FAM107B-like 62.08(n)
60.14(a)
  794256  XM_001334156.3  XP_001334192.3 
fruit fly
(Drosophila melanogaster)
Insecta CG93286
--
18(a)
1 → many
2L(20797717-20814030)


ENSEMBL Gene Tree for FAM107A (if available)
TreeFam Gene Tree for FAM107A (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM107A gene
FAM107B2  
2 SIMAP similar genes for FAM107A using alignment to 4 protein entries:     F107A_HUMAN (see all proteins):
TU3A    FAM107B

FAM107A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/304 NCBI SNPs in FAM107A are shown (see all 304    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs19827581,2
C,F,H--58549647(-) TAGCCC/TACCTA 2 -- ds500134Minor allele frequency- T:0.38NS EA NA WA CSA 3193
rs19827571,2
C,F--58549666(-) TTTCTG/TCACCT 2 -- ds50018Minor allele frequency- T:0.36NA WA EA 368
rs1849229561,2
--58549757(+) GCCTGA/CAGGTA 2 -- ds50010--------
rs1153640851,2
--58549812(+) ATTTTG/TGTTGC 2 -- ds50010--------
rs1874464951,2
--58549840(+) CAACAA/GTGGTT 2 -- ds50010--------
rs1410680181,2
C--58550098(+) TTCCT-/CTTCAA 2 -- ut310--------
rs1433777311,2
--58550210(+) ATACAC/GAGTTG 2 -- ut310--------
rs1928110281,2
--58550243(+) CAAGGA/TCGTCT 2 -- ut310--------
rs98570431,2
C,F,H--58550305(+) CTTCAT/GGGAAT 2 -- ut317Minor allele frequency- G:0.07NS NA WA 912
rs1854928671,2
--58550459(+) TTGGGC/GAAGTG 2 -- ut310--------

HapMap Linkage Disequilibrium report for FAM107A (58549844 - 58613337 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FAM107A: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM107A
DNA2.0 Custom Variant and Variant Library Synthesis for FAM107A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM107A for disorders           About GeneDecksing

OMIM gene information: 608295    OMIM disorders: --

11 diseases for FAM107A:    About MalaCards
renal cell carcinoma    severe combined immunodeficiency    combined immunodeficiency    carcinoma
benign meningioma    rheumatoid arthritis    fibrosarcoma    immunodeficiency
arthritis    meningioma    neuroblastoma

1 disease from the University of Copenhagen DISEASES database for FAM107A:
Benign meningioma

Export disorders for FAM107A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM107A gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with FAM107A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Loss of expression of the DRR1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. (PubMed id 10564580)1, 2, 3 Wang L....Smith D.I. (2000)
  2. Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3->p14.2 in renal cell carcinoma. (PubMed id 10702698)1, 2, 3 Yamato T.... Horii A. (1999)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
  6. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1, 2 Simpson J.C.... Wiemann S. (2000)
  7. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1 Stahl E.A....Plenge R.M. (2010)
  8. DRR1 is expressed in the developing nervous system an d downregulated during neuroblastoma carcinogenesis. (PubMed id 20298674)1 Asano Y....Kadomatsu K. (2010)
  9. Methylation-associated silencing of TU3A in human cancers. (PubMed id 18813805)1 Awakura Y....Ogawa O. (2008)
  10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 11170 HGNC: 30827 AceView: TU3A Ensembl:ENSG00000168309 euGenes: HUgn11170
ECgene: FAM107A H-InvDB: FAM107A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM107A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM107A gene:
Search GeneIP for patents involving FAM107A

GeneCards and IP:
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