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Aliases & Descriptions for FAM107A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DRR1 1 , 2 , 3 FLJ30158 2 FLJ45473 2 TU3A 1 , 2 , 3
Descriptions Down-regulated in renal cell carcinoma 1 3 Protein TU3A 3 downregulated in renal cell carcinoma 2 family with sequence similarity 107 member A transcript 2 family with sequence similarity 107, member A 2
Search outside databases for aliases for FAM107A gene
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and/or
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UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 Function : When transfected into cell lines in which it is not expressed, suppresses cell growth.May play a role in tumor development
Gene Wiki entry for FAM107A
Genomic Location for FAM107A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the FAM107A gene Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p14.2 HGNC cytogenetic band: 3p14.2 FAM107A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M058526:
(about GC identifiers )
Start:
58,524,884 bp from pter
End:
58,538,531 bp from pter
Size:
13,648 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 Proteins for FAM107A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 (See
protein sequence )Recommended Name: Protein FAM107A Size : 144 amino acids; 17455 Da
Subcellular location : Nucleus
Secondary accessions : Q96NH4Alternative splicing : 2 isoforms : O95990-1 O95990-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001070246.1 NP_009108.1 ENSEMBL proteins: ENSP00000354270 ENSP00000377991 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for FAM107A: Assays for FAM107A:
Protein
Domains/ Families for FAM107A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O95990 ProtoNet protein and cluster: O95990
UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 Similarity : Belongs to the FAM107 family
Gene Function for FAM107A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
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Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_007177 Applied Biosystems Silencer ® siRNAs for FAM107A Sigma-Aldrich siRNA for FAM107A Sigma-Aldrich shRNA for FAM107A Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001076778                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001076778                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001076778  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001076778 UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 Function : When transfected into cell lines in which it is not expressed, suppresses cell growth.May play a role in tumor development
2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for FAM107A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/19 Interacting proteins for FAM107A (O95990 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 19
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
About this table
Drugs & Compounds for FAM107A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for FAM107A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_007177 Sigma-Aldrich siRNA for FAM107A Sigma-Aldrich shRNA for FAM107A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001076778 NM_007177
REFSEQ mRNAs for FAM107A gene (2 alternative transcripts): NM_001076778.1 NM_007177.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001076778 NM_007177
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001076778                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001076778                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001076778  
Additional cDNA sequence: AB023811.1 AF035283.1 AF089853.1 AF089854.1 AK054720.1 AK055443.1 AK128791.1 AK298001.1 AK316450.1 AL050264.1 BC010561.1 BC093012.1 CR457133.1 CR591615.1 CR600423.1 CR601858.1 CR607139.1 CR609117.1 CR610702.1 CR617615.1 CR621351.1 EU569833.1
24/26 DOTS entries (see all 26
): DT.100792271 DT.100792274 DT.100792275 DT.40252339 DT.95363147 DT.99988736 DT.40211893 DT.95363151 DT.95363145 DT.100775775 DT.120887427 DT.120887491 DT.120887403 DT.95152986 DT.120887399 DT.120887419 DT.120887493 DT.95324091 DT.100792277 DT.120887379 DT.120887390 DT.120887452 DT.95187780 DT.97788160
24/546 AceView cDNA sequences (see all 546
):CB118038 AA948464 F09483 AI085326 BP347144 AW161103 AI498063 CR621351 BP346562 AL534309 BM671612 CA391608 BM927069 BX463761 BM980503 T33504 BP347703 BG059739 BP347550 BF725098 BQ008292 F03436 BM700459 AA934525
highest scoring ESTs for FAM107A :AF035283 AA021079 AB023811 AF089853 AF089854 AK055443 AK128791 AL050264 AU134947 AW161103
Unigene Cluster for FAM107A: Family with sequence similarity 107, member A Hs.506357 [show with all ESTs ] Unigene Representative Sequence: AF089854 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FAM107A (see all 14
) ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a · SP1 :                                           -       -     SP2 :         -     -   -   -   -   -   -   -                   -           SP3 :                                           -           SP4 :                         -                   -       -     SP5 :     -   -   -     -   -   -   -   -   -   -                            
ExUns: 12b · 12c ^ 13 SP1 :       SP2 :       SP3 :       SP4 :       SP5 :      
About this scheme ECgene alternative splicing isoforms for FAM107A 2 Ensembl transcripts including schematic representations : ENST00000360997
ENST00000394481
Expression for FAM107A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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FAM107A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for FAM107A 1 / 2 / 3
6 probe-sets matching FAM107A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACAAAAAGGCSOURCE GeneReport for Unigene cluster: Hs.506357 UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 Tissue specificity : Widely expressed in normal tissues. Expression is reduced or absent in a numberof cancer cell lines
Orthologs for FAM107A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for FAM107A gene from 5/8 species (see all 8
)
About this table Species with no ortholog for FAM107A ENSEMBL Gene Tree for FAM107A Paralogs for FAM107A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for FAM107A gene FAM107B 2
SNPs/Variants for FAM107A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for FAM107A (up to first 250kb)
Disorders & Mutations for FAM107A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608295
Medical News for FAM107A (Possibly Related Articles in
Doctor's Guide )
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--
Publications for FAM107A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/17 PubMed articles for FAM107A gene (see all 17
): Loss of expression of the DRR1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. (PubMed id 10564580) 2, 3, 4 Wang L....Smith D.I. (2000) Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3->p14.2 in renal cell carcinoma. (PubMed id 10702698) 2, 3, 4 Yamato T.... Horii A. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614) 3, 4 Simpson J.C.... Wiemann S. (2000) Methylation-associated silencing of TU3A in human cancers. (PubMed id 18813805) 3 Awakura Y....Ogawa O. (2008) Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931) 3 Ewing R.M....Figeys D. (2007) The LIFEdb database in 2006. (PubMed id 16381901) 3 Mehrle A....Wiemann S. (2006) Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PubMed id 16432833) 3 Kholodnyuk I.D....Imreh S. (2006)
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Genome Databases showing FAM107A
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing FAM107A
(According to HUGE )
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Specialized Databases showing FAM107A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for FAM107A (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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