V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

FAM107A Gene

protein-coding   GIFtS: 50

GC03M058526
family with sequence similarity 107, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DRR1 1, 2, 3
FLJ30158 2
FLJ45473 2
TU3A 1, 2, 3
Descriptions
Down-regulated in renal cell carcinoma 1 3
Protein TU3A 3
downregulated in renal cell carcinoma 2
family with sequence similarity 107 member A transcript 2
family with sequence similarity 107, member A 2
External Ids
HGNC: 308271
Entrez Gene: 111702
UniProtKB: O959903
Ensembl: ENSG000001683097
Search outside databases for aliases for FAM107A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
Function: When transfected into cell lines in which it is not expressed, suppresses cell growth.
May play a role in tumor development

Gene Wiki entry for FAM107A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAM107A gene  

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p14.2   HGNC cytogenetic band: 3p14.2

FAM107A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M058526:     (about GC identifiers)

Start:
58,524,884 bp from pter
End:
58,538,531 bp from pter
Size:
13,648 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: F107A_HUMAN, O95990 (See protein sequence)
Recommended Name: Protein FAM107A  
Size: 144 amino acids; 17455 Da
Subcellular location: Nucleus
Secondary accessions: Q96NH4
Alternative splicing: 2 isoforms:  O95990-1   O95990-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001070246.1  NP_009108.1  


    ENSEMBL proteins: 
    ENSP00000354270 ENSP00000377991 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FAM107A)
    Human Recombinant Proteins from Abnova (FAM107A)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA10564580
    About this table

    Antibodies for FAM107A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FAM107A
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (FAM107A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FAM107A)
    Novus Biologicals Antibodies for FAM107A

    Assays for FAM107A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR009533 DUF1151


       GeneDecks  FAM107A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O95990

    ProtoNet protein and cluster: O95990

    UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
    Similarity: Belongs to the FAM107 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM107A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007177

                  Applied Biosystems Silencer® siRNAs for FAM107A

                  Sigma-Aldrich siRNA for FAM107A  
                         Sigma-Aldrich shRNA for FAM107A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAM107A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001076778
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001076778
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001076778 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001076778

    UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
    Function: When transfected into cell lines in which it is not expressed, suppresses cell growth.
    May play a role in tumor development

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    GO:0005515 protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/19 Interacting proteins for FAM107A (O959901, 2) via UniProtKB, MINT, and/or STRING (see all 19 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCDP816051EBI-743396, EBI-395625
    PPP2R2AP631511EBI-743396, EBI-1048931
    BEGAINQ9BUH82MINT-67853
    CALCOCO2Q131372MINT-68354
    CANXP278242MINT-63629
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558 regulation of cell growth IDA10564580
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAM107A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM107A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007177

                  Sigma-Aldrich siRNA for FAM107A  
                         Sigma-Aldrich shRNA for FAM107A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001076778  NM_007177  

    REFSEQ mRNAs for FAM107A gene (2 alternative transcripts): 

    NM_001076778.1   NM_007177.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001076778  NM_007177  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001076778
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001076778
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001076778 

    Additional cDNA sequence: 

    AB023811.1 AF035283.1 AF089853.1 AF089854.1 AK054720.1 AK055443.1 AK128791.1 AK298001.1 
    AK316450.1 AL050264.1 BC010561.1 BC093012.1 CR457133.1 CR591615.1 CR600423.1 CR601858.1 
    CR607139.1 CR609117.1 CR610702.1 CR617615.1 CR621351.1 EU569833.1 

    24/26 DOTS entries (see all 26 ):

    DT.100792271  DT.100792274  DT.100792275  DT.40252339  DT.95363147  DT.99988736  DT.40211893  DT.95363151 
    DT.95363145  DT.100775775  DT.120887427  DT.120887491  DT.120887403  DT.95152986  DT.120887399  DT.120887419 
    DT.120887493  DT.95324091  DT.100792277  DT.120887379  DT.120887390  DT.120887452  DT.95187780  DT.97788160 

    24/546 AceView cDNA sequences (see all 546 ):

    CB118038 AA948464 F09483 AI085326 BP347144 AW161103 AI498063 CR621351 
    BP346562 AL534309 BM671612 CA391608 BM927069 BX463761 BM980503 T33504 
    BP347703 BG059739 BP347550 BF725098 BQ008292 F03436 BM700459 AA934525 

    highest scoring ESTs for FAM107A:

    AF035283 AA021079 AB023811 AF089853 AF089854 AK055443 AK128791 AL050264 AU134947 AW161103 

    Unigene Cluster for FAM107A:

    Family with sequence similarity 107, member A
    Hs.506357  [show with all ESTs]
    Unigene Representative Sequence: AF089854


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FAM107A (see all 14 )

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a ·
    SP1:                                                                                                                                -                 -         
    SP2:                          -           -     -     -     -     -     -     -                                                     -                           
    SP3:                                                                                                                                -                           
    SP4:                                                                          -                                                     -                 -         
    SP5:              -     -     -           -     -     -     -     -     -     -                                                                                 

    ExUns: 12b · 12c ^ 13
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  

    About this scheme

    ECgene alternative splicing isoforms for FAM107A

    2 Ensembl transcripts including schematic representations:
    ENST00000360997  ENST00000394481  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAM107A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAM107A

    1 / 2 / 3

    6 probe-sets matching FAM107A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    45260_at2, 3 U95-B 1 1.00 1.00 0.99 1.04 W22565 0.40 1.00 0.76 1

    38044_at2, 3 U95-A 1 1.00 1.00 0.82 0.98 AF035283 1.00 1.00 1.00 1

    207547_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_007177 0.60 1.00 0.82 1

    209074_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL050264 0.80 1.00 0.91 1

    207547_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    209074_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FAM107A for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACAAAAAGGC

    SOURCE GeneReport for Unigene cluster: Hs.506357

    UniProtKB/Swiss-Prot: F107A_HUMAN, O95990
    Tissue specificity: Widely expressed in normal tissues. Expression is reduced or absent in a number
    of cancer cell lines

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FAM107A gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6073801   -- similar to downregulated in renal cell carcinoma 90.97(n)
    96.53(a)
    607380  XM_844019.1  XP_849112.1 
    chimpanzee
    (Pan troglodytes)
    FAM107A1   -- downregulated in renal cell carcinoma 99.54(n)
    100(a)
    747580  XM_001174309.1  XP_001174309.1 
    cow
    (Bos taurus)
    MGC1431031   -- hypothetical LOC538515 92.36(n)
    95.83(a)
    538515  XM_580825.3  XP_580825.2 
    rat
    (Rattus norvegicus)
    Fam107a1   -- family with sequence similarity 107, member A 87.04(n)
    91.67(a)
    361018  NM_001025129.1  NP_001020300.1 
    mouse
    (Mus musculus)
    Fam107a1, 5 145
    family with sequence similarity 107, member A1, 5 86.34(n)1
    90.97(a)1
    2687091  NM_183187.31  NP_899010.11 
     AK0384875  AK0442195  (see all 7)
    About this table        Species with no ortholog for FAM107A

    ENSEMBL Gene Tree for FAM107A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FAM107A gene
    FAM107B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/116 NCBI SNPs in FAM107A are shown (see all 116 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 55)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs21205771,2
    A,C,F,H,O58526840(+) GGCCAC/TCTGCA 2 -- ut31 ese37Minor allele frequency- T:0.22NA EU EA WA 520
    rs23066711,2
    A,C,F,H,O58538191(+) AAACCC/TCTGGG 2 -- ut519Minor allele frequency- N:0.00EA NA EU WA 2118
    rs64459901,2
    A,C,F,H58538840(+) ATGTGC/GAGCAT 2 -- ng3112Minor allele frequency- N:0.00EU EA WA NA 1048
    rs108660201,2
    A,C,F,H58539477(+) GAAGTG/ATTTTC 2 -- ng318Minor allele frequency- A:0.49EU EA WA NA 780
    --
    rs10439561,2
    A,C,F58526611(-) TACAGC/ATTCTA 2 -- ut31 ese31Minor allele frequency- A:0.29MN 184
    rs115390861,2
    C,F,H58527369(-) GCGAAG/CAGAGA 2 Q/E mis1 trp312Minor allele frequency- C:0.11EU EA WA 1232
    --
    rs10439731,2
    A,C,F58526287(-) TGTACA/GTGATT 2 -- ut31 ese31Minor allele frequency- G:0.12MN 184
    rs98132811,2
    A,C,F58540255(+) CCCACC/ACTGCT 2 -- ng312Minor allele frequency- A:0.41NA 182
    rs10439421,2
    C,F,H58528037(-) TGGAAG/TCCAAG 2 A/S mis15Minor allele frequency- T:0.09MN EU EA WA 588
    rs170594101,2
    C,F,H58538323(+) CCACGA/TTGCGG 2 -- ut5111Minor allele frequency- T:0.02NA EU EA WA 978
    About this table

    HapMap Linkage Disequilibrium images for FAM107A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608295

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/17 PubMed articles for FAM107A gene (see all 17 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11170 HGNC: 30827 AceView: TU3A Ensembl:ENSG00000168309 euGenes: HUgn11170
    ECgene: FAM107A H-InvDB: FAM107A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAM107A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM107A-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAM107A Antibodies for FAM107A
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FAM107A Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (FAM107A)
     Antibodies (FAM107A)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (FAM107A)
     Antibodies (FAM107A)
     Search OriGene for FAM107A
     Search Tocris compounds for FAM107A




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FAM107A

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    FAM107A Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com