FAM105B Gene
protein-coding GIFtS: 46
GCID: GC05P014666
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family with sequence similarity 105, member B
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Aliases
for FAM105B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 105, Member B1 2 | | FLJ348841 | | Protein FAM105B2 |
Export aliases for FAM105B gene to outside databasesPrevious GC identifers: GC05P014718 GC05P014665 GC05P014637 |
Summaries
for FAM105B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM105B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM105B gene promoter:
Sox5 SREBP-1c GCNF LCR-F1 SREBP-1b AREB6 SREBP-1a GCNF-1 IRF-7A GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM105B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM105B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2FAM105B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P014666: view genomic region
(about GC identifiers)
Start:
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14,664,773 bp from pter |
End:
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14,699,842 bp from pter |
Size:
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35,070 bases |
Orientation:
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plus strand |
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Proteins
for FAM105B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F105B_HUMAN, Q96BN8 (See
protein sequence)Recommended Name: Protein FAM105B Size: 352 amino acids; 40263 Da
Sequence caution: Sequence=AAH07706.3; Type=Erroneous initiation; Sequence=AAH15392.2; Type=Erroneous initiation;Sequence=BAC03828.1; Type=Erroneous initiation;
Secondary accessions: D3DTD3 Q8NAS0 Q96IA3Explore the universe of human proteins at neXtProt for FAM105B: NX_Q96BN8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BN8
FAM105B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612357.4
ENSEMBL proteins: ENSP00000427016 ENSP00000284274 ENSP00000421928 ENSP00000424966
Human Recombinant Protein Products:
FAM105B Antibody Products:
Assay Products for FAM105B: |
Protein
Domains /
Families
for FAM105B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM105B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96BN8ProtoNet protein and cluster: Q96BN8 UniProtKB/Swiss-Prot: F105B_HUMAN, Q96BN8Similarity: Belongs to the FAM105 family |
Function
for FAM105B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM105B (NM_138348) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM105B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM105B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM105B |
1 GenomeRNAi human phenotype for FAM105B:
|
Pathways & Interactions
for FAM105B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM105B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/559 Interacting proteins for FAM105B (Q96BN82, 3 ENSP000002842744) via UniProtKB, MINT, STRING, and/or I2D (see all 559)About this table
|
Drugs & Compounds
for FAM105B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM105B
Search CenterWatch for drugs/clinical trials and news about FAM105B / F105B
|
Transcripts
for FAM105B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM105B gene: NM_138348.4 Unigene Cluster for FAM105B: Family with sequence similarity 105, member B Hs.406335 [show with all ESTs]Unigene Representative Sequence: NM_1383486 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503023 ENST00000507335 ENST00000284274(uc003jfk.3) ENST00000514913
ENST00000506417 ENST00000508678
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM105B (NM_138348) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM105B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM105B |
Additional cDNA sequence: AK092203.1 AK095615.1 AK123480.1 BC007706.2 BC015392.1 6 DOTS entries: DT.456027 DT.422750 DT.120864481 DT.100018838 DT.40282289 DT.91697295 24/151 AceView cDNA sequences (see all 151): BU627327 BM457040 BC007706 AA282169 AI870147 BX484800 BQ922658 AA465239 AA926922 BQ186639 AA728761 CA417491 AA987588 AA465594 NM_138348 BG058615 AA279338 BF968993 AI703372 BG030732 BX095915 AK123480 CA411815 AA360588
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM105B About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 |
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| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM105B
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Expression
for FAM105B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM105B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FAM105B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM105B
SOURCE GeneReport for Unigene cluster: Hs.406335
SABiosciences Custom PCR Arrays for FAM105B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM105B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM105B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM105B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM105B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM105B |
Orthologs
for FAM105B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM105B gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for FAM105B (if available)
TreeFam Gene Tree for FAM105B (if available) |
Paralogs
for FAM105B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM105B gene
- FAM105A2
1 SIMAP similar gene for FAM105B using alignment to 4 protein entries: F105B_HUMAN (see all proteins):FAM105A
FAM105B for paralogs About GeneDecksing
|
Genomic Variants
for FAM105B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM105B (14664773 - 14699842 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM105B
1 Indel: 69016 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM105B |
|
Disorders
/ Diseases
for FAM105B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FAM105B for disorders About MalaCards
FAM105B for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: FAM105B (1 document)
Export disorders for FAM105B gene to outside databases
|
Publications
for FAM105B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM105B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FAM105B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
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External Searches for FAM105B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM105B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM105B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM105B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM105B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FAM105B gene:
Search GeneIP for patents involving FAM105B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM105B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM105B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM105B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM105B | | | OriGene Protein Over-expression Lysate for FAM105B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM105B | | OriGene 3'-UTR Clone for FAM105B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM105B | | OriGene Custom Protein Services for FAM105B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM105B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM105B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM105B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM105B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM105B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM105B |
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| | | | Search Tocris compounds for FAM105B |
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 | | | FAM105B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM105B |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM105B |
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