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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM105B Gene

protein-coding   GIFtS: 48
GCID: GC05P014666

Family With Sequence Similarity 105, Member B

  Search for FAM105B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 105, Member B1 2     gumby2
Deubiquitinating Enzyme Otulin2 3     Protein FAM105B2
Ubiquitin Thioesterase Gumby2 3     Ubiquitin Thioesterase Otulin2
OTU Domain-Containing Deubiquitinase With Linear Linkage Specificity2 3     EC 3.4.19.123

External Ids:    HGNC: 251181   Entrez Gene: 902682   Ensembl: ENSG000001541247   UniProtKB: Q96BN83   

Export aliases for FAM105B gene to outside databases

Previous GC identifers: GC05P014718 GC05P014665 GC05P014637


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM105B Gene: 
FAM105B (family with sequence similarity 105, member B) is a protein-coding gene. An important paralog of this gene is FAM105A.

UniProtKB/Swiss-Prot: OTUL_HUMAN, Q96BN8
Function: Deubiquitinase that specifically removes linear ('M-1'-linked) polyubiquitin chains to substrates and
acts as a regulator of angiogenesis. Associates with the LUBAC complex via direct interaction with RNF31 and
counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis,
craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex.
Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM105B gene promoter:
         Sox5   SREBP-1c   GCNF   LCR-F1   SREBP-1b   AREB6   SREBP-1a   GCNF-1   IRF-7A   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM105B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM105B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM105B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

FAM105B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM105B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P014666:  view genomic region     (about GC identifiers)

Start:
14,664,773 bp from pter      End:
14,699,842 bp from pter
Size:
35,070 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OTUL_HUMAN, Q96BN8 (See protein sequence)
Recommended Name: Ubiquitin thioesterase otulin  
Size: 352 amino acids; 40263 Da
Subunit: Interacts with RNF31; the interaction is direct
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH07706.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH15392.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03828.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for FAM105B:
4KSJ (3D)        4KSK (3D)        4KSL (3D)    
Secondary accessions: D3DTD3 Q8NAS0 Q96IA3

Explore the universe of human proteins at neXtProt for FAM105B: NX_Q96BN8

Explore proteomics data for FAM105B at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated
  • UniProtKB: Acetylated
  • UniProtKB: Phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BN8

  • FAM105B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM105B Protein Expression
    REFSEQ proteins: NP_612357.4  
    ENSEMBL proteins: 
     ENSP00000427016   ENSP00000284274   ENSP00000421928   ENSP00000424966  

    Human Recombinant Protein Products for FAM105B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for FAM105B
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM105B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    FAM105B for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FAM105B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023235 FAM105
     IPR023237 FAM105B

    Graphical View of Domain Structure for InterPro Entry Q96BN8

    ProtoNet protein and cluster: Q96BN8

    UniProtKB/Swiss-Prot: OTUL_HUMAN, Q96BN8
    Domain: The specificity for linear polyubiquitin is given by the 'Glu-16' residue in ubiquitin chain
    (PubMed:23746843)
    Similarity: Belongs to the peptidase C65 family. Otulin subfamily
    Similarity: Contains 1 OTU domain


    FAM105B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OTUL_HUMAN, Q96BN8
    Function: Deubiquitinase that specifically removes linear ('M-1'-linked) polyubiquitin chains to substrates and
    acts as a regulator of angiogenesis. Associates with the LUBAC complex via direct interaction with RNF31 and
    counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis,
    craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex.
    Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Biophysicochemical properties: Kinetic parameters: KM=7.98 uM for linear diubiquitin; Note=Kcat is 6.3 sec(-1)
    with linear diubiquitin as substrate;

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI--
    GO:0008234cysteine-type peptidase activity IMP--
         
    FAM105B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FAM105B:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM105B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM105B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM105B 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM105B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM105B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/587 Interacting proteins for FAM105B (Q96BN82, 3 ENSP000002842744) via UniProtKB, MINT, STRING, and/or I2D (see all 587)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146413, ENSP000000053404I2D: score=4 STRING: ENSP00000005340
    ELAVL1Q157172, ENSP000003852694MINT-7945693 STRING: ENSP00000385269
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002040sprouting angiogenesis ISS--
    GO:0006508proteolysis IEA--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP--
    GO:0045087innate immune response IMP--
    GO:0050728negative regulation of inflammatory response IMP--

    FAM105B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM105B (OTUL)

    Search CenterWatch for drugs/clinical trials and news about FAM105B / OTUL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM105B gene: 
    NM_138348.4  

    Unigene Cluster for FAM105B:

    Family with sequence similarity 105, member B
    Hs.406335  [show with all ESTs]
    Unigene Representative Sequence: NM_138348
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503023 ENST00000507335 ENST00000284274(uc003jfk.3) ENST00000514913
    ENST00000506417 ENST00000508678
    miRNA
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    hsa-miR-1321 hsa-miR-513a-5p hsa-miR-29a hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-218 hsa-miR-507
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Sirion Biotech Customized lentivirus for stable overexpression of FAM105B 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM105B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM105B

    Additional mRNA sequence: 

    AK092203.1 AK095615.1 AK123480.1 BC007706.2 BC015392.1 

    6 DOTS entries:

    DT.456027  DT.422750  DT.120864481  DT.100018838  DT.40282289  DT.91697295 

    24/151 AceView cDNA sequences (see all 151):

    CA417546 BC015392 BQ938781 CA423742 AA360588 AA987588 AA728761 AI703372 
    CA417491 BX095915 BG030732 BF968993 AA279338 BG058615 NM_138348 AA465594 
    BQ186639 AA465239 BF445185 CA411815 AA927538 BG010314 BU627327 BM457040 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM105B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:              -                 -                                 
    SP2:        -     -                 -                                 
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for FAM105B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM105B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM105B Expression
    About this image


    See FAM105B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM105B

    SOURCE GeneReport for Unigene cluster: Hs.406335
        SABiosciences Custom PCR Arrays for FAM105B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM105B gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam105b1 , 5 family with sequence similarity 105, member B1, 5 87.69(n)1
    90.06(a)1
      15 (10.31 cM)5
    4329401  NM_001013792.21  NP_001013814.21 
     276059195 
    chicken
    (Gallus gallus)
    Aves LOC4270971 protein FAM105B-like 68.13(n)
    63.87(a)
      427097  XM_003640779.1  XP_003640827.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM105B6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    4(60643273-60685163)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ060002.12   -- 75.11(n)    BJ060002.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000016651 uncharacterized LOC100001665 56.23(n)
    47.47(a)
      100001665  XM_001341582.3  XP_001341618.3 


    ENSEMBL Gene Tree for FAM105B (if available)
    TreeFam Gene Tree for FAM105B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM105B gene
    FAM105A2  

    FAM105B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/728 SNPs in FAM105B are shown (see all 728)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425312051,2
    --14662906(+) TTCTGA/GGTGGA 1 -- us2k10--------
    rs1891815691,2
    --14662956(+) TCTCAA/CGGTGG 1 -- us2k10--------
    rs1527851,2
    C,F,H--14663047(+) aaacaT/Cagcat 1 -- us2k1 tfbs315Minor allele frequency- C:0.09NS EA NA WA 1732
    rs1152264001,2
    C--14663132(+) CCTGAC/TGGAAT 1 -- us2k10--------
    rs2015402311,2
    C--14663202(+) CACAAA/CCTGTG 1 -- us2k10--------
    rs1391200171,2
    --14663244(+) AGTTTG/TGGGGG 1 -- us2k10--------
    rs1141022481,2
    C,F--14663304(+) CACTTT/CGGAAT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1930655781,2
    --14663311(+) GAATAA/GTCCTT 1 -- us2k10--------
    rs2508781,2
    C,F,A,H--14663362(+) cggcgT/Cttctt 1 -- us2k18Minor allele frequency- C:0.03NS EA NA 540
    rs1416716611,2
    --14663433(+) TGCACA/GTTTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM105B (14664773 - 14699842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FAM105B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4728CNV Insertion18451855
    esv1000304CNV Insertion20482838
    nsv830211CNV Loss17160897
    esv28342CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM105B for disorders           About MalaCards

    FAM105B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM105B
    Human Genome Epidemiology (HuGE) Navigator: FAM105B (1 document)

    Export disorders for FAM105B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM105B gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with FAM105B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. (PubMed id 23708998)1, 2 Rivkin E.... Cordes S.P. (2013)
    2. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1- linked polyubiquitin. (PubMed id 23746843)1, 2 Keusekotten K.... Komander D. (2013)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. (PubMed id 23806334)1 Fiil B.K....Gyrd-Hansen M. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90268 HGNC: 25118 AceView: LOC90268 Ensembl:ENSG00000154124 euGenes: HUgn90268
    ECgene: FAM105B H-InvDB: FAM105B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM105B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM105B gene:
    Search GeneIP for patents involving FAM105B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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