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FAM105B Gene

protein-coding GIFtS: 38

GC05P014718

family with sequence similarity 105, member B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ34884 ^¹, ²

Descriptions
family with sequence similarity 105, member B ^²
hypothetical protein LOC90268 ^²

External Ids
HGNC: 25118¹
Entrez Gene: 90268²
UniProtKB: Q96BN8³
Ensembl: ENSG00000154124⁷

Search outside databases for aliases for FAM105B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM105B gene

Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2

FAM105B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P014718: (about GC identifiers)

Start:	14,717,783 bp from pter
End:	14,752,842 bp from pter
Size:	35,060 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F105B_HUMAN, Q96BN8 (See protein sequence)

Recommended Name: Protein FAM105B

Size: 352 amino acids; 40263 Da

Secondary accessions: Q8NAS0 Q96IA3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_612357.4

ENSEMBL proteins:

ENSP00000284274

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for FAM105B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM105B

Assays for FAM105B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96BN8

UniProtKB/Swiss-Prot: F105B_HUMAN, Q96BN8

Similarity: Belongs to the FAM105 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM105B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138348

Applied Biosystems Silencer® siRNAs for FAM105B

Sigma-Aldrich siRNA for FAM105B

Sigma-Aldrich shRNA for FAM105B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM105B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_138348
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138348
untagged cDNA clones in CMV expression vector (see all 3): AK095615

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_138348

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM105B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM105B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138348

Sigma-Aldrich siRNA for FAM105B

Sigma-Aldrich shRNA for FAM105B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_138348

REFSEQ mRNAs for FAM105B gene:

NM_138348.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_138348

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138348
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138348
                                 untagged cDNA clones in CMV expression vector (see all 3): AK095615

Additional cDNA sequence:

AK092203.1 AK095615.1 AK123480.1 BC007706.2 BC015392.1

6 DOTS entries:

DT.456027 DT.422750 DT.120864481 DT.100018838 DT.40282289 DT.91697295

24/151 AceView cDNA sequences (see all 151 ):

AA279338 BQ922658 BC015392 BQ938781 BM457040 AA987588 BC007706 AA728761

AW662159 BI062601 AI873183 BF968993 BF437971 CB129522 BI062750 BF445185

AK123480 AA926922 BQ187227 BQ186639 AA927538 AA465239 AI703372 BG010314

highest scoring ESTs for FAM105B:

AI075950 AI659556 AA004324 AA004436 AA337118 AA337506 AI377006 AI873183 AI948597 AI962289

Unigene Cluster for FAM105B:

Family with sequence similarity 105, member B

Hs.406335 [show with all ESTs]

Unigene Representative Sequence: NM_138348

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM105B

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7
SP1:					-						-
SP2:			-		-						-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for FAM105B

1 Ensembl transcript including schematic representation:

ENST00000284274

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FAM105B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM105B

¹ / ² / ³

9 probe-sets matching FAM105B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55420_at²^{, 3}	U95-B	1	1.00	1.00	0.73	0.74	AI659556	1.00	1.00	1.00	1
88727_at²^{, 3}	U95-D	1	1.00	1.00	0.77	1.02	AA236686	0.60	1.00	0.82	1
50172_at²^{, 3}	U95-B	1	1.00	1.00	0.71	1.51	AI377006	0.80	1.00	0.91	1
50410_at²^{, 3}	U95-C	1	1.00	1.00	0.96	1.11	AI075950	1.00	1.00	1.00	1
87480_at²^{, 3}	U95-E	1	0.31	1.00	0.64	0.65	AI813337	0.60	1.00	0.82	1
229268_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA723152	0.60	1.00	0.82	1
228382_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI659556	1.00	1.00	1.00	1
229268_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228382_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FAM105B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.406335

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM105B gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC461733¹	--	hypothetical LOC461733	99.9(n) 100(a)	461733 XM_517640.2 XP_517640.2
cow (Bos taurus)	LOC508963¹	--	hypothetical LOC508963	86.74(n) 88.64(a)	508963 XM_585824.3 XP_585824.3
mouse (Mus musculus)	Fam105b^{1, 5}	15⁵	family with sequence similarity 105, member B^{1, 5}	85.98(n)¹ 89.72(a)¹	432940¹ NM_001013792.1¹ NP_001013814.1¹ AK134955⁵ AK150371⁵ (see all 9)
zebrafish (Danio rerio)	LOC100001665¹	--	similar to Protein FAM105B	57.69(n) 48.85(a)	100001665 XM_001341582.1 XP_001341618.1
African clawed frog (Xenopus laevis)	BJ060002.1²	--	--	75.11(n)	BJ060002.1

About this table Species with no ortholog for FAM105B

ENSEMBL Gene Tree for FAM105B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM105B gene

FAM105A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/154 NCBI SNPs in FAM105B are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs25952^1,2	C,F,H,O	14748247(+)	`TGCTTC/ATGTCC`	1	--	ut3¹		11	NA PA EA EU WA	816
	rs39609^1,2	A,C,F,H	14750914(+)	`CAGTAC/TAAGGA`	1	--	ut3¹		5	MN EU EA WA	604
	rs10065032^1,2	A,C,F,H	14753035(+)	`GAGACG/ATCTTA`	1	--	ng3¹		4	EU EA WA	420
	rs31994^1,2	C,F,H,O	14752582(+)	`CAAACC/TACTTT`	1	--	ut3¹		7	NA EU EA WA	556
--	rs152785^1,2	C,F,H	14716047(+)	`aaacaT/Cagcat`	1	--	ng5¹ tfbs³		8	EU EA WA	838
	rs6886163^1,2	C,F,H	14750849(+)	`CAATTA/GATCTC`	1	--	ut3¹		8	EU EA WA	840
	rs9312870^1,2	C,F,H	14746030(+)	`GTACAA/GCACGG`	1	N/S	mis¹ ese³		15	EU EA WA NA	1398
	rs25951^1,2	C,F,H	14746480(+)	`TTTATA/GTCTCA`	1	--	ut3¹ ese³		8	NA EA EU WA	2146
	rs17363829^1,2	C,F,H	14746398(+)	`TTGGAC/TGGTGC`	1	--	ut3¹ ese³		11	NA EU EA WA	982
	rs11953822^1,2	C,F,H	14734711(+)	`AGCTCA/TTGCTG`	1	M/L	mis¹ ese³		8	EU EA WA	840

About this table

HapMap Linkage Disequilibrium images for FAM105B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for FAM105B gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 90268	HGNC: 25118	AceView: LOC90268	Ensembl:ENSG00000154124	euGenes: HUgn90268
ECgene: FAM105B	H-InvDB: FAM105B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM105B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM105B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM105B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM105B		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM105B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for FAM105B

Search Tocris compounds for FAM105B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM105B

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FAM105B Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for FAM105B

Summaries
for FAM105B

Genomic Location
for FAM105B

Proteins
for FAM105B

Protein Domains/
Families
for FAM105B

Gene Function
for FAM105B

Pathways & Interactions
for FAM105B

Drugs & Compounds
for FAM105B

Transcripts
for FAM105B

Expression
for FAM105B

Orthologs
for FAM105B

Paralogs
for FAM105B

SNPs/Variants
for FAM105B

Disorders & Mutations
for FAM105B

Medical News
for FAM105B

Publications
for FAM105B

Search for FAM105B

Genome Databases showing FAM105B

Other Databases showing FAM105B

Specialized Databases showing FAM105B

Licensable Technologies
for FAM105B

Services
for FAM105B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM105B Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor FAM105B

Summariesfor FAM105B

Genomic Locationfor FAM105B

Proteinsfor FAM105B

Protein Domains/Familiesfor FAM105B

Gene Functionfor FAM105B

Pathways & Interactionsfor FAM105B

Drugs & Compoundsfor FAM105B

Transcriptsfor FAM105B

Expression for FAM105B

Orthologsfor FAM105B

Paralogsfor FAM105B

SNPs/Variantsfor FAM105B

Disorders & Mutationsfor FAM105B

Medical Newsfor FAM105B

Publicationsfor FAM105B

Search for FAM105B

Genome Databases showing FAM105B

Other Databases showing FAM105B

Specialized Databases showing FAM105B

Licensable Technologiesfor FAM105B

Servicesfor FAM105B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM105B

Summaries
for FAM105B

Genomic Location
for FAM105B

Proteins
for FAM105B

Protein Domains/
Families
for FAM105B

Gene Function
for FAM105B

Pathways & Interactions
for FAM105B

Drugs & Compounds
for FAM105B

Transcripts
for FAM105B

Expression
for FAM105B

Orthologs
for FAM105B

Paralogs
for FAM105B

SNPs/Variants
for FAM105B

Disorders & Mutations
for FAM105B

Medical News
for FAM105B

Publications
for FAM105B

Licensable Technologies
for FAM105B

Services
for FAM105B