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FAM105A Gene

protein-coding GIFtS: 43

GC05P014635

family with sequence similarity 105, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ11127 ^¹, ²
FLJ43660 ^²

Descriptions
family with sequence similarity 105, member A ^²
hypothetical protein LOC54491 ^²

External Ids
HGNC: 25629¹
Entrez Gene: 54491²
UniProtKB: Q9NUU6³
Ensembl: ENSG00000145569⁷

Search outside databases for aliases for FAM105A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM105A gene

Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2

FAM105A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P014635: (about GC identifiers)

Start:	14,634,932 bp from pter
End:	14,664,205 bp from pter
Size:	29,274 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F105A_HUMAN, Q9NUU6 (See protein sequence)

Recommended Name: Protein FAM105A

Size: 356 amino acids; 42196 Da

Secondary accessions: Q53H50 Q9H037

REFSEQ proteins: NP_061891.1

ENSEMBL proteins:

ENSP00000274217

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FAM105A)
	Human Recombinant Proteins from Abnova (FAM105A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for FAM105A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FAM105A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FAM105A), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM105A

Assays for FAM105A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9NUU6

UniProtKB/Swiss-Prot: F105A_HUMAN, Q9NUU6

Similarity: Belongs to the FAM105 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM105A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019018

Applied Biosystems Silencer® siRNAs for FAM105A

Sigma-Aldrich siRNA for FAM105A

Sigma-Aldrich shRNA for FAM105A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM105A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019018
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019018
untagged cDNA clones in CMV expression vector (see all 2): NM_019018

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019018

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for FAM105A (ENSP00000274217³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TMEM187	ENSP00000358999³	STRING (score=.712)
SLC25A38	ENSP00000273158³	STRING (score=.706)
TMEM59L	ENSP00000262817³	STRING (score=.706)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM105A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM105A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019018

Sigma-Aldrich siRNA for FAM105A

Sigma-Aldrich shRNA for FAM105A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019018

REFSEQ mRNAs for FAM105A gene:

NM_019018.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019018

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019018
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019018
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_019018

Additional cDNA sequence:

AF052146.1 AK001989.1 AK125648.1 AK222731.1 AL512750.1 BC011524.1 CR591591.1 CR610688.1

6 DOTS entries:

DT.445159 DT.40200400 DT.100774059 DT.99936308 DT.120827504 DT.97836404

24/98 AceView cDNA sequences (see all 98 ):

CF147267 BC011524 BM129108 BM129598 AU137314 AK001989 NM_019018 AI422880

AL512750 AV713277 BM511889 AA515293 AA468536 CR610688 CD243120 BF917932

BQ029788 CR591591 BQ030158 CD673191 BM799850 BM987888 AW138881 BX359474

highest scoring ESTs for FAM105A:

AA233208 AA133798 AA886808 AI818363 AK001989 AL512750 AV715966 AV732875 AW138881 AW954734

Unigene Cluster for FAM105A:

Family with sequence similarity 105, member A

Hs.155085 [show with all ESTs]

Unigene Representative Sequence: NM_019018

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM105A

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8
SP1:
SP2:									-
SP3:

About this scheme

ECgene alternative splicing isoforms for FAM105A

1 Ensembl transcript including schematic representation:

ENST00000274217

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM105A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM105A

¹ / ² / ³

9 probe-sets matching FAM105A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62996_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.01	AA233208	1.00	1.00	1.00	1
36350_at²^{, 3}	U95-A	2	1.00	0.97	0.01	0.31	AF052146	0.20	0.33	0.27	2
80878_at²^{, 3}	U95-D	1	0.56	1.00	0.98	1.00	AA581439	0.20	1.00	0.72	1
244650_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA581439	0.20	1.00	0.72	1
219694_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_019018	0.60	1.00	0.82	1
214947_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF052146	0.20	0.33	0.27	2
244650_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219694_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214947_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FAM105A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TATCTGTATA

SOURCE GeneReport for Unigene cluster: Hs.155085

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM105A gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC606782¹	--	hypothetical protein LOC606782	88.33(n) 88.13(a)	606782 XM_843187.1 XP_848280.1
chimpanzee (Pan troglodytes)	LOC745031¹	--	hypothetical protein LOC745031	99.44(n) 99.44(a)	745031 XM_001148036.1 XP_001148036.1
cow (Bos taurus)	MGC143209¹	--	hypothetical LOC534389	87.19(n) 87.85(a)	534389 XM_614142.3 XP_614142.2
rat (Rattus norvegicus)	Fam105a¹	--	family with sequence similarity 105, member A	82.15(n) 84.14(a)	310190 NM_001037648.1 NP_001032737.1
mouse (Mus musculus)	Fam105a^{1, 5}	15⁵	family with sequence similarity 105, member A^{1, 5}	82.95(n)¹ 82.84(a)¹	223433¹ NM_198301.1¹ NP_938043.1¹ AK036522⁵ AK134932⁵ (see all 13)

About this table Species with no ortholog for FAM105A

ENSEMBL Gene Tree for FAM105A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM105A gene

FAM105B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/130 NCBI SNPs in FAM105A are shown (see all 130 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 77)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs25959^1,2	A,C,F,H,O	14664106(+)	`CCAGCG/TTAATA`	1	--	ut3¹ ese³		12	EU EA WA NA	1052
	rs31978^1,2	A,C,F,H	14634556(-)	`AGTGCT/GGTTTC`	1	--	ng5¹		4	EU EA WA	418
	rs11750625^1,2	C,F,H	14664548(+)	`ccaggG/Cagttg`	1	--	ng3¹		4	EU EA WA	420
	rs16903574^1,2	C,F,H	14663309(+)	`CTGTTC/GAAGTT`	1	F/L	mis¹		12	NA EU EA WA	1056
	rs26172^1,2	C,F	14634335(-)	`AACTGT/CCCTCT`	1	--	ng5¹		3	NA PA	180
	rs6875531^1,2	H	14655354(+)	`GATAAC/TTATGA`	1	N/N	syn¹		3	EA WA	276
	rs31975^1,2	A,C,F,H,O	14659841(+)	`TTTGGC/TTAAAA`	1	--	int¹		8	EU EA WA NA	636
	rs152619^1,2	A,C,F,H,O	14637695(-)	`TTTTCC/TGTGTA`	1	--	int¹		16	MN EA NA EU WA	2856
	rs250184^1,2	A,C,F,H,O	14652926(-)	`ACAGGC/ACTAGA`	1	--	int¹		20	EU EA WA NA	1834
	rs152614^1,2	A,C,F,H	14650216(-)	`gggggA/Gaaaca`	1	--	int¹ trp³		5	MN EU EA WA	602

About this table

HapMap Linkage Disequilibrium images for FAM105A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for FAM105A gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)³ Yu W....Gibbs R.A. (1997)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)³ Andersson B....Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54491	HGNC: 25629	AceView: FLJ11127	Ensembl:ENSG00000145569	euGenes: HUgn54491
ECgene: FAM105A	H-InvDB: FAM105A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM105A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM105A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM105A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM105A		Antibodies for FAM105A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM105A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FAM105A)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for FAM105A

Search Tocris compounds for FAM105A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM105A

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FAM105A Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for FAM105A

Summaries
for FAM105A

Genomic Location
for FAM105A

Proteins
for FAM105A

Protein Domains/
Families
for FAM105A

Gene Function
for FAM105A

Pathways & Interactions
for FAM105A

Drugs & Compounds
for FAM105A

Transcripts
for FAM105A

Expression
for FAM105A

Orthologs
for FAM105A

Paralogs
for FAM105A

SNPs/Variants
for FAM105A

Disorders & Mutations
for FAM105A

Medical News
for FAM105A

Publications
for FAM105A

Search for FAM105A

Genome Databases showing FAM105A

Other Databases showing FAM105A

Specialized Databases showing FAM105A

Licensable Technologies
for FAM105A

Services
for FAM105A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM105A Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor FAM105A

Summariesfor FAM105A

Genomic Locationfor FAM105A

Proteinsfor FAM105A

Protein Domains/Familiesfor FAM105A

Gene Functionfor FAM105A

Pathways & Interactionsfor FAM105A

Drugs & Compoundsfor FAM105A

Transcriptsfor FAM105A

Expression for FAM105A

Orthologsfor FAM105A

Paralogsfor FAM105A

SNPs/Variantsfor FAM105A

Disorders & Mutationsfor FAM105A

Medical Newsfor FAM105A

Publicationsfor FAM105A

Search for FAM105A

Genome Databases showing FAM105A

Other Databases showing FAM105A

Specialized Databases showing FAM105A

Licensable Technologiesfor FAM105A

Servicesfor FAM105A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM105A

Summaries
for FAM105A

Genomic Location
for FAM105A

Proteins
for FAM105A

Protein Domains/
Families
for FAM105A

Gene Function
for FAM105A

Pathways & Interactions
for FAM105A

Drugs & Compounds
for FAM105A

Transcripts
for FAM105A

Expression
for FAM105A

Orthologs
for FAM105A

Paralogs
for FAM105A

SNPs/Variants
for FAM105A

Disorders & Mutations
for FAM105A

Medical News
for FAM105A

Publications
for FAM105A

Licensable Technologies
for FAM105A

Services
for FAM105A