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Aliases for FAM105A Gene

Aliases for FAM105A Gene

  • Family With Sequence Similarity 105 Member A 2 3 5
  • Family With Sequence Similarity 105, Member A 2
  • Inactive Ubiquitin Thioesterase FAM105A 3
  • Protein FAM105A 3
  • NET20 3

External Ids for FAM105A Gene

Previous GeneCards Identifiers for FAM105A Gene

  • GC05P014635

Summaries for FAM105A Gene

GeneCards Summary for FAM105A Gene

FAM105A (Family With Sequence Similarity 105 Member A) is a Protein Coding gene. An important paralog of this gene is OTULIN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM105A Gene

Genomics for FAM105A Gene

Regulatory Elements for FAM105A Gene

Enhancers for FAM105A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F014674 1.5 FANTOM5 Ensembl ENCODE 10.8 +94.2 94192 2.7 HDGF CBX3 TBL1XR1 WRNIP1 SIN3A ZBTB40 CBX5 CREM SMARCA5 ZBTB2 OTULIN FAM105A GC05P014689
GH05F014490 0.7 Ensembl ENCODE 16.1 -89.6 -89616 2.5 RFX1 ZBTB33 FOS FAM105A GC05P014542 ENSG00000281325
GH05F014559 0.7 Ensembl ENCODE 12.6 -21.7 -21676 2.2 POLR2A SMARCA4 FAM105A GC05M014575 GC05P014542
GH05F014544 0.7 FANTOM5 Ensembl 12.1 -36.4 -36375 1.2 IKZF1 SPI1 FAM105A GC05P014542 GC05M014575
GH05F014659 0.6 ENCODE 10.8 +78.5 78539 1.3 ZNF316 PKNOX1 MAFF BHLHE40 EMSY MAFK FAM105A ENSG00000261360 EEF1A1P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM105A on UCSC Golden Path with GeneCards custom track

Promoters for FAM105A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001275893 425 2001 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 SP3 NFYC GLIS1

Genomic Location for FAM105A Gene

14,581,775 bp from pter
14,616,180 bp from pter
34,406 bases
Plus strand

Genomic View for FAM105A Gene

Genes around FAM105A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM105A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM105A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM105A Gene

Proteins for FAM105A Gene

  • Protein details for FAM105A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ubiquitin thioesterase FAM105A
    Protein Accession:
    Secondary Accessions:
    • Q53H50
    • Q9H037

    Protein attributes for FAM105A Gene

    356 amino acids
    Molecular mass:
    42196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM105A Gene

Post-translational modifications for FAM105A Gene

  • Ubiquitination at Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM105A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM105A Gene

Domains & Families for FAM105A Gene

Gene Families for FAM105A Gene

Protein Domains for FAM105A Gene


Suggested Antigen Peptide Sequences for FAM105A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 OTU domain.
  • Belongs to the peptidase C65 family. Otulin subfamily.
  • Contains 1 OTU domain.
  • Belongs to the peptidase C65 family. Otulin subfamily.
genes like me logo Genes that share domains with FAM105A: view

Function for FAM105A Gene

Phenotypes for FAM105A Gene

genes like me logo Genes that share phenotypes with FAM105A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM105A Gene

Localization for FAM105A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM105A gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM105A Gene

Pathways & Interactions for FAM105A Gene

SuperPathways for FAM105A Gene

No Data Available

Interacting Proteins for FAM105A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000274217 Q9NUU6-F105A_HUMAN for FAM105A Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM105A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM105A Gene

Transcripts for FAM105A Gene

Unigene Clusters for FAM105A Gene

Family with sequence similarity 105, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM105A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP2: -

Relevant External Links for FAM105A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM105A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM105A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM105A Gene

This gene is overexpressed in Whole Blood (x8.5) and Lung (x4.8).

Protein differential expression in normal tissues from HIPED for FAM105A Gene

This gene is overexpressed in Monocytes (17.5), Breast (14.1), Peripheral blood mononuclear cells (10.5), and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM105A Gene

Protein tissue co-expression partners for FAM105A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM105A Gene:


SOURCE GeneReport for Unigene cluster for FAM105A Gene:

genes like me logo Genes that share expression patterns with FAM105A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM105A Gene

Orthologs for FAM105A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM105A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM105A 34 35
  • 99.44 (n)
(Canis familiaris)
Mammalia FAM105A 34 35
  • 88.5 (n)
(Bos Taurus)
Mammalia MGC143209 35
  • 88 (a)
FAM105A 34
  • 87.85 (n)
(Mus musculus)
Mammalia Fam105a 34 16 35
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Fam105a 34
  • 82.15 (n)
(Monodelphis domestica)
Mammalia FAM105A 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FAM105A 35
  • 75 (a)
(Gallus gallus)
Aves FAM105A 34 35
  • 69.49 (n)
(Anolis carolinensis)
Reptilia FAM105A 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam105a 34
  • 63.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
Species where no ortholog for FAM105A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM105A Gene

Gene Tree for FAM105A (if available)
Gene Tree for FAM105A (if available)

Paralogs for FAM105A Gene

Paralogs for FAM105A Gene

(1) SIMAP similar genes for FAM105A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM105A: view

Variants for FAM105A Gene

Sequence variations from dbSNP and Humsavar for FAM105A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036723 -- 14,601,892(+) CATAT(A/G)AAGTA intron-variant
rs10075214 -- 14,609,265(+) CTCAC(A/G)CTGCT intron-variant
rs10475016 -- 14,587,871(+) TTGAA(C/T)TTTGA intron-variant
rs111269935 -- 14,614,844(+) TCTGT(A/G)TGTAA nc-transcript-variant, utr-variant-3-prime
rs111270931 -- 14,591,948(+) ATGGA(A/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM105A Gene

Variant ID Type Subtype PubMed ID
nsv950652 CNV duplication 24416366
nsv830211 CNV loss 17160897
nsv597247 CNV gain 21841781
nsv1026914 CNV gain 25217958
nsv1018187 CNV gain 25217958
esv3604095 CNV loss 21293372
esv2729814 CNV deletion 23290073
esv2662370 CNV deletion 23128226
esv23916 CNV loss 19812545
dgv9609n54 CNV loss 21841781
dgv9608n54 CNV gain+loss 21841781
dgv9607n54 CNV gain 21841781
dgv9606n54 CNV gain 21841781
dgv9605n54 CNV gain 21841781
dgv936n67 CNV loss 20364138

Variation tolerance for FAM105A Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM105A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM105A Gene

Disorders for FAM105A Gene

Relevant External Links for FAM105A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM105A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM105A Gene

Publications for FAM105A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. (PMID: 23708998) Rivkin E. … Cordes S.P. (Nature 2013) 4 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for FAM105A Gene

Sources for FAM105A Gene

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