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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM105A Gene

protein-coding GIFtS: 44
GCID: GC05P014581

family with sequence similarity 105, member A

Explore 1 disease affiliated with
FAM105A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 105, Member A¹ ²
NET20¹ ²
FLJ11127¹
Protein FAM105A²

External Ids:	HGNC: 25629¹	Entrez Gene: 54491²	Ensembl: ENSG00000145569⁷	UniProtKB: Q9NUU6³

Export aliases for FAM105A gene to outside databases

Previous GC identifer: GC05P014635

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM105A gene promoter:
USF1 SREBP-1c HNF-4alpha2 HNF-4alpha1 SREBP-1b E47 N-Myc SREBP-1a USF-1 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FAM105A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM105A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2

FAM105A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM105A gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P014581: view genomic region (about GC identifiers)

Start:	14,581,884 bp from pter	End:	14,616,289 bp from pter
Size:	34,406 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F105A_HUMAN, Q9NUU6 (See protein sequence)

Recommended Name: Protein FAM105A

Size: 356 amino acids; 42196 Da

Secondary accessions: Q53H50 Q9H037

Explore the universe of human proteins at neXtProt for FAM105A: NX_Q9NUU6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NUU6

FAM105A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061891.1

ENSEMBL proteins:

ENSP00000274217

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM105A for domains About GeneDecksing

2 InterPro domains/families:

IPR023235 FAM105

IPR023236 FAM105A

Graphical View of Domain Structure for InterPro Entry Q9NUU6

ProtoNet protein and cluster: Q9NUU6

UniProtKB/Swiss-Prot: F105A_HUMAN, Q9NUU6

Similarity: Belongs to the FAM105 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM105A

miRNA Products:		miRTarBase miRNAs that target FAM105A: hsa-let-7b (MIRT001633)

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		SwitchGear 3'UTR luciferase reporter plasmid: FAM105A 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM105A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM105A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FAM105A (ENSP00000274217⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM105A
Search CenterWatch for drugs/clinical trials and news about FAM105A / F105A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM105A gene:

NM_019018.2

Unigene Cluster for FAM105A:

Family with sequence similarity 105, member A

Hs.155085 [show with all ESTs]

Unigene Representative Sequence: NM_019018

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000274217(uc003jfj.3) ENST00000513825 ENST00000506258

miRNA Products:		OriGene 3'-UTR Clone: FAM105A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM105A
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM105A (see all 33):
		hsa-miR-582-3p hsa-miR-2052 hsa-miR-140-5p hsa-miR-520d-5p hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-548m hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: FAM105A 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM105A (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM105A
		Sirion Biotech Custom design and validation of potent shRNA sequences against FAM105A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM105A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM105A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM105A

Additional cDNA sequence:

AF052146.1 AK001989.1 AK125648.1 AK222731.1 AL512750.1 BC011524.1

6 DOTS entries:

DT.445159 DT.40200400 DT.99936308 DT.100774059 DT.120827504 DT.97836404

24/98 AceView cDNA sequences (see all 98):

AA515293 BQ029788 CD243120 AV713277 BQ030158 CD673191 BF917932 CR610688

BM129598 AI422880 AK001989 BC011524 BM987888 BM511889 BM129108 BM799850

AL512750 NM_019018 AU137314 AA468536 CF147267 CR591591 CF146919 AK125648

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM105A About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8
SP1:
SP2:									-
SP3:

ECgene alternative splicing isoforms for FAM105A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM105A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTGTATA

About this image

FAM105A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM105A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM105A

SOURCE GeneReport for Unigene cluster: Hs.155085

SABiosciences Custom PCR Arrays for FAM105A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM105A Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM105A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM105A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM105A gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM105A¹	family with sequence similarity 105, member A	69.49(n) 63.84(a)		769855 NM_001079746.1 NP_001073214.1
lizard (Anolis carolinensis)	Reptilia	FAM105A⁶	--	58(a)	1 ↔ 1	4(61057265-61066329)

ENSEMBL Gene Tree for FAM105A (if available)
TreeFam Gene Tree for FAM105A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM105A gene

FAM105B²

1 SIMAP similar gene for FAM105A using alignment to 2 protein entries: F105A_HUMAN (see all proteins):

FAM105B

FAM105A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1610862^1,2	C,F	--	14579927(+)	`TGAAC-/TAGTAGGT`	1	--	us2k¹		4		EU NA EA	342
rs186480908^1,2		--	14580177(+)	`AAGACC/TATGTG`	1	--	us2k¹		0	--	--	--	--
rs189935503^1,2		--	14580203(+)	`CACTAC/GGCAGT`	1	--	us2k¹		0	--	--	--	--
rs181497484^1,2		--	14580300(+)	`AAATCC/TTAAAT`	1	--	us2k¹		0	--	--	--	--
rs186136983^1,2		--	14580332(+)	`TAGGCC/TAAGAA`	1	--	us2k¹		0	--	--	--	--
rs190855491^1,2		--	14580371(+)	`TGTGGA/GAGGAG`	1	--	us2k¹		0	--	--	--	--
rs147235770^1,2		--	14580442(+)	`TACCGC/TAAGAA`	1	--	us2k¹		0	--	--	--	--
rs139696253^1,2		--	14580494(+)	`ACTTGC/TCACTG`	1	--	us2k¹		0	--	--	--	--
rs149523448^1,2		--	14580515(+)	`TGTTTA/GGGTTA`	1	--	us2k¹		0	--	--	--	--
rs75287819^1,2	C	--	14580948(+)	`TCTCAA/CTGGAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM105A (14581884 - 14616289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FAM105A
1 Indel: 69015

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM105A for disorders About GeneDecksing

1 disease for FAM105A: About MalaCards

amenorrhea

Export disorders for FAM105A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM105A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM105A)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)¹ Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)¹ Andersson B.... Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54491	HGNC: 25629	AceView: FLJ11127	Ensembl:ENSG00000145569	euGenes: HUgn54491
ECgene: FAM105A	H-InvDB: FAM105A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM105A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM105A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM105A gene:
Search GeneIP for patents involving FAM105A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM105A gene at Home site.

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FAM105A Gene

family with sequence similarity 105, member A

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Export list of displayed genes

FAM105A Gene

family with sequence similarity 105, member A

Aliasesfor FAM105A gene

Summariesfor FAM105A gene

Genomic Viewsfor FAM105A gene

Proteinsfor FAM105A gene

Protein Domains /Familiesfor FAM105A gene

Functionfor FAM105A gene

Pathways & Interactionsfor FAM105A gene

Drugs & Compoundsfor FAM105A gene

Transcriptsfor FAM105A gene

Expression for FAM105A gene

Orthologsfor FAM105A gene

Paralogsfor FAM105A gene

Genomic Variantsfor FAM105A gene

Disorders / Diseasesfor FAM105A gene

Publicationsfor FAM105A gene

External Searches for FAM105A gene

Genome Databases showing FAM105A gene

Other Databases showing FAM105A gene

Specialized Databases showing FAM105A gene

Intellectual Propertyfor FAM105A gene

Productsfor FAM105A gene

View Random Gene

Aliases
for FAM105A gene

Summaries
for FAM105A gene

Genomic Views
for FAM105A gene

Proteins
for FAM105A gene

Protein Domains /
Families
for FAM105A gene

Function
for FAM105A gene

Pathways & Interactions
for FAM105A gene

Drugs & Compounds
for FAM105A gene

Transcripts
for FAM105A gene

Expression
for FAM105A gene

Orthologs
for FAM105A gene

Paralogs
for FAM105A gene

Genomic Variants
for FAM105A gene

Disorders / Diseases
for FAM105A gene

Publications
for FAM105A gene

Intellectual Property
for FAM105A gene

Products
for FAM105A gene