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Aliases for FAM105A Gene

Aliases for FAM105A Gene

  • Family With Sequence Similarity 105, Member A 2 3
  • Inactive Ubiquitin Thioesterase FAM105A 3
  • Protein FAM105A 3
  • NET20 3

External Ids for FAM105A Gene

Previous GeneCards Identifiers for FAM105A Gene

  • GC05P014635

Summaries for FAM105A Gene

GeneCards Summary for FAM105A Gene

FAM105A (Family With Sequence Similarity 105, Member A) is a Protein Coding gene. An important paralog of this gene is OTULIN.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM105A Gene

Genomics for FAM105A Gene

Regulatory Elements for FAM105A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM105A Gene

Start:
14,581,775 bp from pter
End:
14,616,180 bp from pter
Size:
34,406 bases
Orientation:
Plus strand

Genomic View for FAM105A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM105A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM105A Gene

Proteins for FAM105A Gene

  • Protein details for FAM105A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUU6-F105A_HUMAN
    Recommended name:
    Inactive ubiquitin thioesterase FAM105A
    Protein Accession:
    Q9NUU6
    Secondary Accessions:
    • Q53H50
    • Q9H037

    Protein attributes for FAM105A Gene

    Size:
    356 amino acids
    Molecular mass:
    42196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM105A Gene

Proteomics data for FAM105A Gene at MOPED

Post-translational modifications for FAM105A Gene

  • Ubiquitination at Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM105A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM105A Gene

Domains for FAM105A Gene

Gene Families for FAM105A Gene

HGNC:
  • OTUD :OTU domain containing

Protein Domains for FAM105A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM105A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUU6

UniProtKB/Swiss-Prot:

F105A_HUMAN :
  • Q9NUU6
Domain:
  • Contains 1 OTU domain.
Family:
  • Belongs to the peptidase C65 family. Otulin subfamily.
genes like me logo Genes that share domains with FAM105A: view

Function for FAM105A Gene

Animal Model Products

CRISPR Products

miRNA for FAM105A Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM105A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM105A Gene

Localization for FAM105A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM105A Gene COMPARTMENTS Subcellular localization image for FAM105A gene
Compartment Confidence
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM105A Gene

Pathways for FAM105A Gene

SuperPathways for FAM105A Gene

No Data Available

Interacting Proteins for FAM105A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274217%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000274217 for FAM105A Gene via STRING

Gene Ontology (GO) - Biological Process for FAM105A Gene

None

No data available for Pathways by source for FAM105A Gene

Transcripts for FAM105A Gene

mRNA/cDNA for FAM105A Gene

Unigene Clusters for FAM105A Gene

Family with sequence similarity 105, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM105A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM105A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1:
SP2: -
SP3:

Relevant External Links for FAM105A Gene

GeneLoc Exon Structure for
FAM105A
ECgene alternative splicing isoforms for
FAM105A

Expression for FAM105A Gene

mRNA expression in normal human tissues for FAM105A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM105A Gene

This gene is overexpressed in Whole Blood (8.5) and Lung (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM105A Gene

SOURCE GeneReport for Unigene cluster for FAM105A Gene Hs.155085

genes like me logo Genes that share expressions with FAM105A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM105A Gene

Orthologs for FAM105A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM105A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM105A 35
  • 99.44 (n)
  • 99.44 (a)
FAM105A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM105A 35
  • 87.85 (n)
  • 88.14 (a)
MGC143209 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM105A 35
  • 88.5 (n)
  • 88.5 (a)
FAM105A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam105a 35
  • 83.1 (n)
  • 84.42 (a)
Fam105a 16
Fam105a 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM105A 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM105A 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam105a 35
  • 82.15 (n)
  • 84.14 (a)
chicken
(Gallus gallus)
Aves FAM105A 35
  • 69.49 (n)
  • 63.84 (a)
FAM105A 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM105A 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam105a 35
  • 63.03 (n)
  • 54.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for FAM105A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM105A Gene

ENSEMBL:
Gene Tree for FAM105A (if available)
TreeFam:
Gene Tree for FAM105A (if available)

Paralogs for FAM105A Gene

Paralogs for FAM105A Gene

Selected SIMAP similar genes for FAM105A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM105A: view

Variants for FAM105A Gene

Sequence variations from dbSNP and Humsavar for FAM105A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs25958 -- 14,613,953(+) TAATT(C/G)TGTCC utr-variant-3-prime
rs25959 -- 14,610,997(+) CCAGC(G/T)TAATA utr-variant-3-prime
rs25960 -- 14,610,075(-) CGGTG(C/G)GGGGA intron-variant
rs25961 -- 14,609,243(-) GCCCC(C/G)AGAAT intron-variant
rs26172 -- 14,581,226(-) AACTG(C/T)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM105A Gene

Variant ID Type Subtype PubMed ID
nsv830211 CNV Loss 17160897
esv23916 CNV Loss 19812545
esv2729814 CNV Deletion 23290073
esv2662370 CNV Deletion 23128226
dgv936n67 CNV Loss 20364138

Relevant External Links for FAM105A Gene

HapMap Linkage Disequilibrium report
FAM105A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM105A Gene

Disorders for FAM105A Gene

No disorders were found for FAM105A Gene.

No data available for UniProtKB/Swiss-Prot for FAM105A Gene

Publications for FAM105A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for FAM105A Gene

Sources for FAM105A Gene

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