FAM104B Gene
protein-coding GIFtS: 41
GCID: GC0XM055186
|
|
family with sequence similarity 104, member B(Previous name: chromosome X open reading frame 44 )
(Previous symbol: CXorf44)
| |
Aliases
for FAM104B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Family With Sequence Similarity 104, Member B1 2 | | CXorf441 2 3 | | FLJ204341 | | Chromosome X Open Reading Frame 441 | | Protein FAM104B2 |
| External Ids: | HGNC: 250851 | Entrez Gene: 907362 | Ensembl: ENSG000001825187 | UniProtKB: Q5XKR93 | | ORGUL members: | |
|---|
| NONCODE:n408888 | |
Export aliases for FAM104B gene to outside databasesPrevious GC identifer: GC0XM052219
|---|
Summaries
for FAM104B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM104B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM104B gene promoter:
Nkx3-1 Nkx3-1 v1 Nkx2-5 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 GATA-2 MEF-2A S8 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM104B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM104B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.22FAM104B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM055186: view genomic region
(about GC identifiers)
Start:
|
55,169,535 bp from pter |
End:
|
55,187,743 bp from pter |
Size:
|
18,209 bases |
Orientation:
|
minus strand |
|
Proteins
for FAM104B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F104B_HUMAN, Q5XKR9 (See
protein sequence)Recommended Name: Protein FAM104B Size: 115 amino acids; 13109 Da
Secondary accessions: A6NEH1 B4DSV6 E9PH40 Q8WVU5 Q9BRA1Alternative splicing: 4 isoforms: Q5XKR9-1 Q5XKR9-2 Q5XKR9-3 Q5XKR9-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM104B: NX_Q5XKR9
FAM104B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001160171.1 NP_001160172.1 NP_001160173.1 NP_001160174.1 NP_001160175.1 NP_001160176.1 NP_612371.2
ENSEMBL proteins: ENSP00000364101 ENSP00000420895 ENSP00000421161 ENSP00000423164 ENSP00000333394 ENSP00000397188
Human Recombinant Protein Products for FAM104B:
FAM104B Antibody Products:
Assay Products for FAM104B: |
Protein
Domains /
Families
for FAM104B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5XKR9 UniProtKB/Swiss-Prot: F104B_HUMAN, Q5XKR9Similarity: Belongs to the FAM104 family |
Function
for FAM104B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM104B (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM104B (see all 7)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 7): FAM104B (NM_001166701) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM104B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM104B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM104B |
|
Pathways & Interactions
for FAM104B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM104B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FAM104B (Q5XKR93 ENSP000003333944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM104B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM104B
Search CenterWatch for drugs/clinical trials and news about FAM104B / F104B
|
Transcripts
for FAM104B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM104B gene (7 alternative transcripts): NM_001166699.1 NM_001166700.1 NM_001166701.1 NM_001166702.1 NM_001166703.1 NM_001166704.1 NM_138362.3 Unigene Cluster for FAM104B: Family with sequence similarity 104, member B Hs.415414 [show with all ESTs]Unigene Representative Sequence: NM_0011667037 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358460(uc004duh.2) ENST00000472571 ENST00000477847(uc022bxn.1)
ENST00000489298 ENST00000478918 ENST00000332132(uc022bxl.1 uc004dug.2)
ENST00000425133(uc022bxm.1 uc022bxo.1 uc022bxp.1 uc004dui.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM104B (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM104B (see all 7)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): FAM104B (NM_001166701) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM104B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM104B |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM104B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM104B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM104B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM104B |
Additional cDNA sequence: AK000441.1 AK299935.1 AK311333.1 AK311699.1 BC000919.2 BC006406.2 BC017571.1 NR_030722.1 8 DOTS entries: DT.440827 DT.40111465 DT.99957386 DT.100780911 DT.121288047 DT.209575 DT.95369321 DT.92421565 24/128 AceView cDNA sequences (see all 128): BE646164 AW163244 AI742475 BQ008910 BC017571 BI850888 AA843753 AI369864 BQ215751 BX100076 BM663509 AI499798 BF476227 BC006406 AW206271 CR591055 AA563794 H90684 BQ772137 BC000919 AI190785 BM014954 N31946 AI199617
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FAM104B (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAM104B
|
Expression
for FAM104B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM104B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAATTAGG
About this image
See FAM104B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM104B
SOURCE GeneReport for Unigene cluster: Hs.415414
SABiosciences Custom PCR Arrays for FAM104B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM104B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM104B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM104B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM104B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM104B |
Orthologs
for FAM104B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM104B gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4174506 |
hypothetical protein LOC417450 |
41(a) |
1 → many |
18(9012406-9021771) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
41(a) |
1 → many |
2(96806177-96812074) |
Species with no ortholog for FAM104B
ENSEMBL Gene Tree for FAM104B (if available)
TreeFam Gene Tree for FAM104B (if available) |
Paralogs
for FAM104B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM104B gene
- FAM104A2
1 SIMAP similar gene for FAM104B using alignment to 3 protein entries: F104B_HUMAN (see all proteins):FAM104A
FAM104B for paralogs About GeneDecksing
|
Genomic Variants
for FAM104B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM104B (55169535 - 55187743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for FAM104B
7 CNVs: 43647 44416 44414 23256 63100 62973 44415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM104B |
|
Disorders
/ Diseases
for FAM104B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM104B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM104B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM104B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for FAM104B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM104B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM104B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM104B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM104B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM104B gene:
Search GeneIP for patents involving FAM104B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM104B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM104B | | | OriGene Protein Over-expression Lysate for FAM104B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM104B | | OriGene 3'-UTR Clone for FAM104B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM104B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM104B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM104B | | OriGene Custom Protein Services for FAM104B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM104B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM104B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM104B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM104B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM104B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM104B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM104B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM104B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM104B |
|  |  |  |  | | | | ThermoFisher Antibodies for FAM104B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM104B |
| |  | |
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356980-web2.xennexinc.com
index build: 106 solr: 1.4
|
