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Aliases for FAM104B Gene

Aliases for FAM104B Gene

  • Family With Sequence Similarity 104 Member B 2 3 5
  • CXorf44 3 4
  • Family With Sequence Similarity 104, Member B 2
  • Chromosome X Open Reading Frame 44 2
  • Protein FAM104B 3

External Ids for FAM104B Gene

Previous HGNC Symbols for FAM104B Gene

  • CXorf44

Previous GeneCards Identifiers for FAM104B Gene

  • GC0XM055186
  • GC0XM052219

Summaries for FAM104B Gene

GeneCards Summary for FAM104B Gene

FAM104B (Family With Sequence Similarity 104 Member B) is a Protein Coding gene. An important paralog of this gene is FAM104A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM104B Gene

Genomics for FAM104B Gene

Regulatory Elements for FAM104B Gene

Enhancers for FAM104B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF055159 1 ENCODE 9.7 +0.3 346 2.4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1 ZNF143 FAM104B LOC100421179
GH0XF055141 0.7 ENCODE 0.3 +18.4 18373 1.9 DRAP1 HMG20B FOXA3 GFI1B ZIC2 HIC1 HNF1A NFE2 PRDM1 TCF7L2 LOC100421179 FAM104B
GH0XF055160 0.2 ENCODE 0.8 +1.7 1668 0.2 FAM104B LOC100421179
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM104B on UCSC Golden Path with GeneCards custom track

Promoters for FAM104B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160755 310 2000 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1 ZNF143

Genomic Location for FAM104B Gene

Chromosome:
X
Start:
55,143,102 bp from pter
End:
55,161,310 bp from pter
Size:
18,209 bases
Orientation:
Minus strand

Genomic View for FAM104B Gene

Genes around FAM104B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM104B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM104B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM104B Gene

Proteins for FAM104B Gene

  • Protein details for FAM104B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKR9-F104B_HUMAN
    Recommended name:
    Protein FAM104B
    Protein Accession:
    Q5XKR9
    Secondary Accessions:
    • A6NEH1
    • B4DSV6
    • D6R9S5
    • D6RDJ5
    • E9PH40
    • Q8WVU5
    • Q9BRA1

    Protein attributes for FAM104B Gene

    Size:
    115 amino acids
    Molecular mass:
    13109 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM104B Gene

neXtProt entry for FAM104B Gene

Post-translational modifications for FAM104B Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM104B Gene

Domains & Families for FAM104B Gene

Protein Domains for FAM104B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM104B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XKR9

UniProtKB/Swiss-Prot:

F104B_HUMAN :
  • Belongs to the FAM104 family.
Family:
  • Belongs to the FAM104 family.
genes like me logo Genes that share domains with FAM104B: view

No data available for Gene Families for FAM104B Gene

Function for FAM104B Gene

Phenotypes for FAM104B Gene

GenomeRNAi human phenotypes for FAM104B:
genes like me logo Genes that share phenotypes with FAM104B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM104B Gene

Localization for FAM104B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM104B gene
Compartment Confidence
nucleus 4
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM104B Gene

Pathways & Interactions for FAM104B Gene

SuperPathways for FAM104B Gene

No Data Available

Interacting Proteins for FAM104B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333394%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000333394 Q5XKR9-F104B_HUMAN for FAM104B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM104B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM104B Gene

Transcripts for FAM104B Gene

Unigene Clusters for FAM104B Gene

Family with sequence similarity 104, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM104B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7:
SP8: -

Relevant External Links for FAM104B Gene

GeneLoc Exon Structure for
FAM104B
ECgene alternative splicing isoforms for
FAM104B

Expression for FAM104B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM104B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM104B Gene:

FAM104B

SOURCE GeneReport for Unigene cluster for FAM104B Gene:

Hs.415414
genes like me logo Genes that share expression patterns with FAM104B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM104B Gene

Orthologs for FAM104B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM104B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM104B 34 35
  • 99.71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem29 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM104A 35
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
Species where no ortholog for FAM104B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM104B Gene

ENSEMBL:
Gene Tree for FAM104B (if available)
TreeFam:
Gene Tree for FAM104B (if available)

Paralogs for FAM104B Gene

Paralogs for FAM104B Gene

(1) SIMAP similar genes for FAM104B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM104B: view

Variants for FAM104B Gene

Sequence variations from dbSNP and Humsavar for FAM104B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1047034 -- 55,146,275(-) GCCGC(A/C)TTAAT nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1047037 -- 55,146,254(-) GAGCA(A/G)GTGGA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1047042 -- 55,146,212(-) AACCC(C/G)ATGCA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1047054 -- 55,146,104(-) AGCAG(C/T)GAGGG intron-variant, reference, utr-variant-3-prime, stop-gained
rs1047059 -- 55,146,038(-) AAAAG(C/T)AATTG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM104B Gene

Variant ID Type Subtype PubMed ID
dgv146e19 CNV loss 19470904
dgv49e194 CNV deletion 18987734
esv2740175 CNV deletion 23290073
esv2740181 CNV deletion 23290073
esv2740182 CNV deletion 23290073
esv3742 CNV loss 18987735
esv8730 CNV loss 19470904
nsv435891 CNV deletion 17901297
nsv515205 CNV loss 21397061

Variation tolerance for FAM104B Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM104B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM104B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM104B Gene

Disorders for FAM104B Gene

Relevant External Links for FAM104B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM104B

No disorders were found for FAM104B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM104B Gene

Publications for FAM104B Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FAM104B Gene

Sources for FAM104B Gene

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