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Aliases for FAM104A Gene

Aliases for FAM104A Gene

  • Family With Sequence Similarity 104 Member A 2 3 5
  • Family With Sequence Similarity 104, Member A 2

External Ids for FAM104A Gene

Previous GeneCards Identifiers for FAM104A Gene

  • GC17M068716
  • GC17M071203
  • GC17M066612

Summaries for FAM104A Gene

GeneCards Summary for FAM104A Gene

FAM104A (Family With Sequence Similarity 104 Member A) is a Protein Coding gene. An important paralog of this gene is FAM104B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM104A Gene

Genomics for FAM104A Gene

Regulatory Elements for FAM104A Gene

Enhancers for FAM104A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G073287 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.2 -55.0 -54998 7.7 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 CDC42EP4 CPSF4L FAM104A C17orf80 GC17M073288 GC17P073281
GH17G073277 1.5 Ensembl ENCODE dbSUPER 11 -42.2 -42194 2.3 FOXA2 ARID4B FEZF1 ZNF2 ZNF48 YY1 PAF1 SP5 MIER2 SMARCA4 CDC42EP4 FAM104A C17orf80 CPSF4L COG1 GC17P073281 PIR39589
GH17G072725 1.5 Ensembl ENCODE dbSUPER 10.1 +509.8 509757 2.9 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 ZNF48 ZNF143 ZNF207 MIER2 COG1 FAM104A C17orf80 GC17P072715 GC17P072756
GH17G073298 1.1 ENCODE dbSUPER 11.2 -61.7 -61739 0.8 HDAC1 KLF1 ETV1 EBF1 THRB RARA ZFHX2 GATA3 NCOR1 GATA2 C17orf80 CPSF4L FAM104A GC17M073288 GC17P073281
GH17G073355 1.1 Ensembl ENCODE dbSUPER 11 -120.5 -120520 3.0 BCOR SREBF2 TEAD4 ZMYM3 REST ZIC2 EP300 TEAD3 GLIS1 KDM1A CDC42EP4 C17orf80 FAM104A COG1 GC17M073289 GC17P073336
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM104A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM104A Gene

Chromosome:
17
Start:
73,207,353 bp from pter
End:
73,236,753 bp from pter
Size:
29,401 bases
Orientation:
Minus strand

Genomic View for FAM104A Gene

Genes around FAM104A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM104A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM104A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM104A Gene

Proteins for FAM104A Gene

  • Protein details for FAM104A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W3-F104A_HUMAN
    Recommended name:
    Protein FAM104A
    Protein Accession:
    Q969W3
    Secondary Accessions:
    • B4E339

    Protein attributes for FAM104A Gene

    Size:
    186 amino acids
    Molecular mass:
    19484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11054.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH25238.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11183.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM104A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM104A Gene

Post-translational modifications for FAM104A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM104A Gene

Domains & Families for FAM104A Gene

Protein Domains for FAM104A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM104A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969W3

UniProtKB/Swiss-Prot:

F104A_HUMAN :
  • Belongs to the FAM104 family.
Family:
  • Belongs to the FAM104 family.
genes like me logo Genes that share domains with FAM104A: view

No data available for Gene Families for FAM104A Gene

Function for FAM104A Gene

Gene Ontology (GO) - Molecular Function for FAM104A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM104A: view
genes like me logo Genes that share phenotypes with FAM104A: view

Animal Models for FAM104A Gene

MGI Knock Outs for FAM104A:

Animal Model Products

CRISPR Products

miRNA for FAM104A Gene

miRTarBase miRNAs that target FAM104A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM104A Gene

Localization for FAM104A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM104A gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM104A Gene

Pathways & Interactions for FAM104A Gene

SuperPathways for FAM104A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM104A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM104A Gene

Drugs & Compounds for FAM104A Gene

No Compound Related Data Available

Transcripts for FAM104A Gene

Unigene Clusters for FAM104A Gene

Family with sequence similarity 104, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM104A Gene

No ASD Table

Relevant External Links for FAM104A Gene

GeneLoc Exon Structure for
FAM104A
ECgene alternative splicing isoforms for
FAM104A

Expression for FAM104A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM104A Gene

mRNA differential expression in normal tissues according to GTEx for FAM104A Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for FAM104A Gene

This gene is overexpressed in CD8 Tcells (38.2), Rectum (14.2), CD4 Tcells (9.7), and Blymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM104A Gene



Protein tissue co-expression partners for FAM104A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM104A Gene:

FAM104A

SOURCE GeneReport for Unigene cluster for FAM104A Gene:

Hs.741276

Evidence on tissue expression from TISSUES for FAM104A Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with FAM104A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM104A Gene

Orthologs for FAM104A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM104A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM104A 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM104A 34
  • 85.45 (n)
MGC128049 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM104A 34 35
  • 83.05 (n)
rat
(Rattus norvegicus)
Mammalia Fam104a 34
  • 82.51 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam104a 34 16 35
  • 76.99 (n)
chicken
(Gallus gallus)
Aves FAM104A 34 35
  • 72.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
OneToMany
Species where no ortholog for FAM104A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM104A Gene

ENSEMBL:
Gene Tree for FAM104A (if available)
TreeFam:
Gene Tree for FAM104A (if available)

Paralogs for FAM104A Gene

Paralogs for FAM104A Gene

(1) SIMAP similar genes for FAM104A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM104A: view

Variants for FAM104A Gene

Sequence variations from dbSNP and Humsavar for FAM104A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs141573449 Uncertain significance 73,208,301(+) CTCTA(C/T)ATCCA intron-variant, utr-variant-3-prime
rs147588256 Uncertain significance 73,208,408(+) TGCAC(C/G)TTCAT reference, missense, utr-variant-3-prime
rs201733537 Uncertain significance 73,207,203(+) TGAGC(A/G)TGACA downstream-variant-500B, reference, missense
rs1000025710 -- 73,212,974(+) GGCGC(A/G)GTGGT intron-variant
rs1000125861 -- 73,212,338(+) ACTCA(A/G)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM104A Gene

Variant ID Type Subtype PubMed ID
esv2186746 CNV deletion 18987734
esv2562139 CNV deletion 19546169
esv2667654 CNV deletion 23128226
esv3641214 CNV loss 21293372
nsv833534 CNV loss 17160897

Variation tolerance for FAM104A Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM104A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM104A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM104A Gene

Disorders for FAM104A Gene

Relevant External Links for FAM104A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM104A

No disorders were found for FAM104A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM104A Gene

Publications for FAM104A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy P.H. … Tagle D.A. (Genomics 1997) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. (PMID: 26389662) Raman M. … Harper J.W. (Nat. Cell Biol. 2015) 3 64

Products for FAM104A Gene

Sources for FAM104A Gene

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