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FAM104A Gene

protein-coding GIFtS: 38

GC17M068716

family with sequence similarity 104, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ14775 ^¹, ²

Descriptions
family with sequence similarity 104, member A ^²
hypothetical protein LOC84923 ^²

External Ids
HGNC: 25918¹
Entrez Gene: 84923²
UniProtKB: Q969W3³
Ensembl: ENSG00000133193⁷

Search outside databases for aliases for FAM104A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM104A gene

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

FAM104A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M068716: (about GC identifiers)

Start:	68,715,087 bp from pter
End:	68,740,128 bp from pter
Size:	25,042 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F104A_HUMAN, Q969W3 (See protein sequence)

Recommended Name: Protein FAM104A

Size: 120 amino acids; 13186 Da

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001092302.1 NP_116226.2

ENSEMBL proteins:

ENSP00000384832 ENSP00000384648 ENSP00000255557

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: FAM104A

Antibodies for FAM104A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FAM104A
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM104A

Assays for FAM104A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q969W3

UniProtKB/Swiss-Prot: F104A_HUMAN, Q969W3

Similarity: Belongs to the FAM104 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM104A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001098832

Applied Biosystems Silencer® siRNAs for FAM104A

Sigma-Aldrich siRNA for FAM104A

Sigma-Aldrich shRNA for FAM104A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM104A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098832
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098832
untagged cDNA clones in CMV expression vector (see all 3): NM_001098832

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001098832

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM104A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM104A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001098832

Sigma-Aldrich siRNA for FAM104A

Sigma-Aldrich shRNA for FAM104A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001098832 NM_032837

REFSEQ mRNAs for FAM104A gene (2 alternative transcripts):

NM_001098832.1 NM_032837.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001098832 NM_032837

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098832
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098832
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001098832

Additional cDNA sequence:

AK027681.1 AK074755.1 AK304556.1 BC011054.1 BC025238.1 BX537858.1 BX648968.1 CR624411.1

U92989.1

17 DOTS entries:

DT.99989533 DT.100824747 DT.100824753 DT.91766570 DT.120979144 DT.120979154 DT.99978632 DT.100029669

DT.97800558 DT.100655618 DT.120979099 DT.95156949 DT.95269183 DT.120979072 DT.120979095 DT.120979174

DT.86851235

24/232 AceView cDNA sequences (see all 232 ):

BM980270 AA890371 AI910446 BF112139 AA242770 BE042985 BM976293 AI863659

AI631597 AA933586 BU630756 BE876431 BM423910 CR624411 AI768146 CB306168

BP342451 AI634908 AK027681 BC025238 AI147224 AI338739 AI090675 CD364915

highest scoring ESTs for FAM104A:

AA250789 AA333013 AA446952 AA490217 AA782480 AA894423 AA993417 AI204369 AI274848 AI304956

Unigene Cluster for FAM104A:

Family with sequence similarity 104, member A

Hs.103555 [show with all ESTs]

Unigene Representative Sequence: NM_001098832

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000405159 ENST00000403627 ENST00000255557

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM104A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM104A

¹ / ² / ³

3 probe-sets matching FAM104A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45287_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AL042487	0.60	1.00	0.82	1
225319_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA127686	0.40	0.67	0.55	1
225319_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FAM104A for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACACAGCAC

SOURCE GeneReport for Unigene cluster: Hs.103555

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM104A gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC475906¹	--	hypothetical LOC475906	89.72(n) 89.17(a)	475906 XM_533113.2 XP_533113.2
cow (Bos taurus)	MGC128049¹	--	hypothetical protein LOC615081	85.51(n) 85.22(a)	615081 NM_001035460.1 NP_001030537.1
rat (Rattus norvegicus)	Fam104a¹	--	family with sequence similarity 104, member A	85.47(n) 85.47(a)	619573 NM_001034958.1 NP_001030130.1
mouse (Mus musculus)	D11Wsu99e^{1, 5}	11 (25.00 cM)⁵	DNA segment, Chr 11, Wayne State University 99, expressed^{1, 5}	85.88(n)¹ 86.44(a)¹	28081¹ NM_138598.3¹ NP_613064.1¹ AA407362⁵ AI849557⁵ (see all 26)
chicken (Gallus gallus)	RCJMB04_10f20¹	--	similar to DNA segment, Chr 11, Wayne State University more	72.22(n) 70.63(a)	417450 NM_001030708.1 NP_001025879.1

About this table Species with no ortholog for FAM104A

ENSEMBL Gene Tree for FAM104A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM104A gene

FAM104B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/199 NCBI SNPs in FAM104A are shown (see all 199 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 109)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4550516^1,2	H	68734971(+)	`TTGTCT/ATCTTC`	2	D/E	mis¹ ese³		4	EU EA WA	416
--	rs8387^1,2	A,C,F,H	68717449(-)	`ATCAAC/TAGCCC`	2	N/N	syn¹ ese³		15	MN NA EU EA WA	1588
	rs7211830^1,2	A,C,F,H	68722365(+)	`GTAAAA/CATCTT`	2	--	int¹		11	NA EU EA WA	976
	rs9900024^1,2	A,C,F,H	68738029(+)	`tgtcaG/Atcaat`	2	--	int¹		4	EU EA WA	416
	rs12451710^1,2	A,C,F,H	68730159(+)	`ACTTGG/AAAAAA`	2	--	int¹		5	EU EA WA NA	1818
	rs11655656^1,2	A,C,F,H	68720555(+)	`TATAAC/TAGCAC`	2	--	int¹		12	EU EA WA NA	1044
	rs7218307^1,2	A,C,F,H	68735613(+)	`TTCTCA/GGACAT`	2	--	int¹		12	NS NA EU EA WA	662
	rs8076989^1,2	A,C,F,H	68723537(+)	`CTACTA/GTGGTG`	2	--	int¹		5	EU EA WA NA	1820
	rs9904400^1,2	A,C,F,H	68721724(+)	`aaTGCC/TACTAG`	2	--	int¹		4	EU EA WA	388
	rs8076745^1,2	A,C,F,H	68735562(+)	`CTTAAT/AATTTC`	2	--	int¹		16	NS NA EU EA WA	2332

About this table

HapMap Linkage Disequilibrium images for FAM104A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for FAM104A gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)³ Reddy P.H....Tagle D.A. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 84923	HGNC: 25918	AceView: FLJ14775	Ensembl:ENSG00000133193	euGenes: HUgn84923
ECgene: FAM104A	H-InvDB: FAM104A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM104A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM104A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM104A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM104A		Antibodies for FAM104A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FAM104A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for FAM104A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM104A

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FAM104A Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for FAM104A

Summaries
for FAM104A

Genomic Location
for FAM104A

Proteins
for FAM104A

Protein Domains/
Families
for FAM104A

Gene Function
for FAM104A

Pathways & Interactions
for FAM104A

Drugs & Compounds
for FAM104A

Transcripts
for FAM104A

Expression
for FAM104A

Orthologs
for FAM104A

Paralogs
for FAM104A

SNPs/Variants
for FAM104A

Disorders & Mutations
for FAM104A

Medical News
for FAM104A

Publications
for FAM104A

Search for FAM104A

Genome Databases showing FAM104A

Other Databases showing FAM104A

Specialized Databases showing FAM104A

Licensable Technologies
for FAM104A

Services
for FAM104A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM104A Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor FAM104A

Summariesfor FAM104A

Genomic Locationfor FAM104A

Proteinsfor FAM104A

Protein Domains/Familiesfor FAM104A

Gene Functionfor FAM104A

Pathways & Interactionsfor FAM104A

Drugs & Compoundsfor FAM104A

Transcriptsfor FAM104A

Expression for FAM104A

Orthologsfor FAM104A

Paralogsfor FAM104A

SNPs/Variantsfor FAM104A

Disorders & Mutationsfor FAM104A

Medical Newsfor FAM104A

Publicationsfor FAM104A

Search for FAM104A

Genome Databases showing FAM104A

Other Databases showing FAM104A

Specialized Databases showing FAM104A

Licensable Technologiesfor FAM104A

Servicesfor FAM104A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM104A

Summaries
for FAM104A

Genomic Location
for FAM104A

Proteins
for FAM104A

Protein Domains/
Families
for FAM104A

Gene Function
for FAM104A

Pathways & Interactions
for FAM104A

Drugs & Compounds
for FAM104A

Transcripts
for FAM104A

Expression
for FAM104A

Orthologs
for FAM104A

Paralogs
for FAM104A

SNPs/Variants
for FAM104A

Disorders & Mutations
for FAM104A

Medical News
for FAM104A

Publications
for FAM104A

Licensable Technologies
for FAM104A

Services
for FAM104A