FAM103A1 Gene
protein-coding GIFtS: 41
GCID: GC15P083654
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|
family with sequence similarity 103, member A1
| |
Aliases
for FAM103A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 103, Member A11 2 | | Protein FAM103A12 3 | | C15orf181 2 3 | | MGC25601 | | RAM1 2 3 | | RNMT-Activating Mini Protein2 | | HsT193601 2 | | |
Export aliases for FAM103A1 gene to outside databasesPrevious GC identifers: GC15P081447 GC15P059918 |
Summaries
for FAM103A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAM_HUMAN, Q9BTL3Function: Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizingmechanism
|
Genomic Views
for FAM103A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_077661.3
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM103A1 gene promoter:
NF-1 AML1a E4BP4 HNF-1A MEF-2A HNF-1 IRF-7A aMEF-2 Pax-4a Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM103A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM103A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q25.2FAM103A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P083654: view genomic region
(about GC identifiers)
Start:
|
83,654,959 bp from pter |
End:
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83,659,809 bp from pter |
Size:
|
4,851 bases |
Orientation:
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plus strand |
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Proteins
for FAM103A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAM_HUMAN, Q9BTL3 (See
protein sequence)Recommended Name: RNMT-activating mini protein Size: 118 amino acids; 14381 Da
Subunit: Interacts with RNMT, enhancing its mRNA binding capacity and cap methyltransferase activity
Subcellular location: Nucleus
Secondary accessions: Q2M1J8Explore the universe of human proteins at neXtProt for FAM103A1: NX_Q9BTL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTL3
FAM103A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113640.1
ENSEMBL proteins: ENSP00000307181
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- | | GO:0005845 | mRNA cap binding complex |
IDA | -- |
FAM103A1 for ontologies About GeneDecksing
FAM103A1 Antibody Products:
Assay Products for FAM103A1: |
Protein
Domains /
Families
for FAM103A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BTL3 UniProtKB/Swiss-Prot: RAM_HUMAN, Q9BTL3Similarity: Belongs to the RAM family |
Function
for FAM103A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAM_HUMAN, Q9BTL3Function: Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizingmechanism
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM103A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM103A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM103A1 (NM_031452) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM103A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM103A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM103A1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FAM103A1 for ontologies About GeneDecksing
|
Pathways & Interactions
for FAM103A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM103A1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/19 Interacting proteins for FAM103A1 (Q9BTL32, 3 ENSP000003071814) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006370 | 7-methylguanosine mRNA capping |
IDA | -- | | GO:0032259 | methylation |
IMP | -- | | GO:0036031 | recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex |
IDA | -- |
FAM103A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FAM103A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM103A1
Search CenterWatch for drugs/clinical trials and news about FAM103A1 / RAM
|
Transcripts
for FAM103A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM103A1 gene: NM_031452.3 Unigene Cluster for FAM103A1: Family with sequence similarity 103, member A1 Hs.744202 [show with all ESTs]Unigene Representative Sequence: NM_0314521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304191(uc002bjl.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM103A1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM103A1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM103A1 (NM_031452) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM103A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM103A1 |
Additional cDNA sequence: AK027095.1 AL049237.1 BC003627.2 BC027181.1 BC112329.1 7 DOTS entries: DT.317694 DT.100842777 DT.100783432 DT.91852738 DT.121016290 DT.102684 DT.91869544 24/169 AceView cDNA sequences (see all 169): BE388283 BC027181 BM468350 AL036346 CR597724 AI160257 AI075243 NM_031452 AL049237 BC003627 AI659427 AA828388 BX394198 CR621664 CB122535 BE892509 AA446786 BQ019278 AA844365 CB161045 BX116945 AL553889 AI741450 BQ425812
GeneLoc Exon Structure
|
Expression
for FAM103A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM103A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGCACAGC
About this image
See FAM103A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM103A1
SOURCE GeneReport for Unigene cluster: Hs.744202
SABiosciences Custom PCR Arrays for FAM103A1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM103A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM103A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM103A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM103A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM103A1 |
Orthologs
for FAM103A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM103A1 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for FAM103A1 (if available)
TreeFam Gene Tree for FAM103A1 (if available) |
Paralogs
for FAM103A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM103A1 gene
FAM103A1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FAM103A1
PGOHUM00000238449 PGOHUM00000238488 PGOHUM00000244432
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Genomic Variants
for FAM103A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM103A1 (83654959 - 83659809 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FAM103A1
1 CNV: 66852
1 Indel: 66851 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM103A1 |
|
Disorders
/ Diseases
for FAM103A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FAM103A1 for disorders About MalaCards
FAM103A1 for disorders About GeneDecksing
OMIM gene information: 614547
OMIM disorders: --
Export disorders for FAM103A1 gene to outside databases
|
Publications
for FAM103A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM103A1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM103A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RAM/Fam103a1 is required for mRNA cap methylation. (PubMed id 22099306)1, 2, 3 Gonatopoulos-Pournatzis T.... Cowling V.H. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAM103A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM103A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM103A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM103A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM103A1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM103A1 gene:
Search GeneIP for patents involving FAM103A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM103A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM103A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM103A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM103A1 | | | OriGene Protein Over-expression Lysate for FAM103A1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM103A1 | | OriGene 3'-UTR Clone for FAM103A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM103A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM103A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAM103A1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM103A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM103A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM103A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM103A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM103A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM103A1 |
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 | | | FAM103A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM103A1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM103A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM103A1 |
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