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FAM103A1 Gene

protein-coding   GIFtS: 41

GC15P081447
family with sequence similarity 103, member A1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
C15orf18 1, 2, 3
HsT19360 1, 2
MGC102778 2
MGC2560 1, 2
OTTHUMP00000017596 2
Descriptions
family with sequence similarity 103, member A1 2
hypothetical protein LOC83640 2
External Ids
HGNC: 310221
Entrez Gene: 836402
UniProtKB: Q9BTL33
Ensembl: ENSG000001696127
Search outside databases for aliases for FAM103A1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAM103A1 gene  

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

FAM103A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P081447:     (about GC identifiers)

Start:
81,445,975 bp from pter
End:
81,450,795 bp from pter
Size:
4,821 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_077661.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F103A_HUMAN, Q9BTL3 (See protein sequence)
Recommended Name: Protein FAM103A1  
Size: 118 amino acids; 14381 Da
Secondary accessions: Q2M1J8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_113640.1  

    ENSEMBL proteins: 
    ENSP00000307181 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for FAM103A1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for FAM103A1

    Assays for FAM103A1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BTL3

    UniProtKB/Swiss-Prot: F103A_HUMAN, Q9BTL3
    Similarity: Belongs to the FAM103 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM103A1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031452

                  Applied Biosystems Silencer® siRNAs for FAM103A1

                  Sigma-Aldrich siRNA for FAM103A1  
                         Sigma-Aldrich shRNA for FAM103A1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAM103A1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_031452
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_031452
                                     untagged cDNA clone in CMV expression vector: NM_031452 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_031452

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for FAM103A1 (Q9BTL32) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622MINT-67221
    RBPMSQ930622MINT-67630
    RHOXF2Q9BQY42MINT-66915
    ENSG00000213516Q5JQ652MINT-66424
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAM103A1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM103A1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_031452

                  Sigma-Aldrich siRNA for FAM103A1  
                         Sigma-Aldrich shRNA for FAM103A1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_031452  

    REFSEQ mRNAs for FAM103A1 gene: 

    NM_031452.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_031452  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_031452
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_031452
                                     untagged cDNA clone in CMV expression vector: NM_031452 

    Additional cDNA sequence: 

    AK027095.1 AL049237.1 BC003627.2 BC027181.1 BC112329.1 CR597724.1 CR621664.1 

    10 DOTS entries:

    DT.317694  DT.100842777  DT.100783432  DT.91852738  DT.121016290  DT.95195817  DT.101986134  DT.102684 
    DT.91869544  DT.91898854 

    24/169 AceView cDNA sequences (see all 169 ):

    CR597724 AA432100 AI741450 AI708045 CR621664 AA446786 AA828388 AL049237 
    AL036346 BE892509 NM_031452 BX116945 AA844365 AL553889 BM468350 BC027181 
    AW009924 BX394198 BQ019278 CB122535 BE388283 AI075243 AI880517 AI659427 

    highest scoring ESTs for FAM103A1:

    AA149415 AA432100 AA446786 AA528758 AI272107 AI560395 AI563952 AI570524 AK027095 AL553889 

    Unigene Cluster for FAM103A1:

    Family with sequence similarity 103, member A1
    Hs.80624  [show with all ESTs]
    Unigene Representative Sequence: AK027095


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000304191  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAM103A1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAM103A1

    1 / 2 / 3

    5 probe-sets matching FAM103A1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    46297_at2, 3 U95-B 2 1.00 0.88 1.00 1.00 AA149415 1.00 1.00 1.00 1

    225210_s_at2, 3 U133-B 2 1.00 0.95 -- -- AW025216 0.60 0.75 0.68 1

    225208_s_at2, 3 U133-B 5 1.00 0.57 -- -- AW575350 0.60 1.00 0.82 1

    225210_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --

    225208_s_at2 U133Plus2 5 1.00 0.57 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATGCACAGC

    SOURCE GeneReport for Unigene cluster: Hs.80624
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FAM103A1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4790561   -- hypothetical LOC479056 91.24(n)
    93.22(a)
    479056  XM_536205.2  XP_536205.1 
    chimpanzee
    (Pan troglodytes)
    LOC4535981   -- hypothetical LOC453598 99.44(n)
    99.15(a)
    453598  XM_510554.2  XP_510554.1 
    cow
    (Bos taurus)
    MGC1277331   -- hypothetical protein LOC614296 89.83(n)
    92.37(a)
    614296  NM_001034757.1  NP_001029929.1 
    rat
    (Rattus norvegicus)
    Fam103a11   -- family with sequence similarity 103, member A1 84.18(n)
    84.75(a)
    293058  XM_214983.4  XP_214983.1 
    mouse
    (Mus musculus)
    2610204K14Rik5
    1000430591
    75
    RIKEN cDNA 2610204K14 gene5
    predicted gene, 1000430591
    85.75(n)1
    88.03(a)1
    1000430591  XM_001478802.11  XP_001478852.11 
     AA4096185  AI8548415  (see all 18)
    About this table        Species with no ortholog for FAM103A1

    ENSEMBL Gene Tree for FAM103A1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    6 NCBI SNPs in FAM103A1 are shown
    (Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs12727271,2
    --81444312(-) caggcA/Ctgagc 1 -- ng510--------
    --
    rs356793021,2
    --81449724(-) CCCCA-/GGGATC 1 S/S fra10--------
    --
    rs360342111,2
    --81450313(-) AATGC-/AAAAAAA 1 -- ut310--------
    --
    rs617385621,2
    --81448804(+) CCAAAG/TTTTGA 1 K/N mis10--------
    --
    rs740308641,2
    --81448716(+) AGAGAA/GTGTTA 1 -- int10--------
    --
    rs355487101,2
    --81448070(-) TTGCT-/ACTGTC 1 -- int10--------
    About this table
    The following additional 21 SNP(s) have been found in Applied Biosystems data source:
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)


     rs12902742 rs7178149 rs4842859 rs1037403 rs12591237 rs11639089 rs8043020
     rs2123158 rs28551018 rs12903275 rs11853521 rs8028887 rs2123157 rs6603038
     rs2167602 rs11854758 rs4548820 rs12910813 rs28430670 rs12439635 rs4842976

    HapMap Linkage Disequilibrium images for FAM103A1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    5 PubMed articles for FAM103A1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 83640 HGNC: 31022 AceView: C6orf119 Ensembl:ENSG00000169612 euGenes: HUgn83640
    ECgene: FAM103A1 H-InvDB: FAM103A1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAM103A1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM103A1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAM103A1 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FAM103A1 Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for FAM103A1

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