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Aliases for FAM103A1 Gene

Aliases for FAM103A1 Gene

  • Family With Sequence Similarity 103, Member A1 2 3
  • RAM 3 4 6
  • RNMT-Activating Mini Protein 2 3
  • Protein FAM103A1 3 4
  • C15orf18 3 4
  • HsT19360 3

External Ids for FAM103A1 Gene

Previous GeneCards Identifiers for FAM103A1 Gene

  • GC15P081447
  • GC15P083654
  • GC15P059918

Summaries for FAM103A1 Gene

GeneCards Summary for FAM103A1 Gene

FAM103A1 (Family With Sequence Similarity 103, Member A1) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for FAM103A1 Gene

  • Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizing mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM103A1 Gene

Genomics for FAM103A1 Gene

Regulatory Elements for FAM103A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM103A1 Gene

82,986,203 bp from pter
82,991,057 bp from pter
4,855 bases
Plus strand

Genomic View for FAM103A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM103A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM103A1 Gene

Proteins for FAM103A1 Gene

  • Protein details for FAM103A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNMT-activating mini protein
    Protein Accession:
    Secondary Accessions:
    • Q2M1J8

    Protein attributes for FAM103A1 Gene

    118 amino acids
    Molecular mass:
    14381 Da
    Quaternary structure:
    • Interacts with RNMT, enhancing its mRNA binding capacity and cap methyltransferase activity.

neXtProt entry for FAM103A1 Gene

Proteomics data for FAM103A1 Gene at MOPED

Post-translational modifications for FAM103A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM103A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM103A1 Gene

Domains for FAM103A1 Gene

Protein Domains for FAM103A1 Gene


Suggested Antigen Peptide Sequences for FAM103A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BTL3
  • Belongs to the RAM family.
genes like me logo Genes that share domains with FAM103A1: view

No data available for Gene Families for FAM103A1 Gene

Function for FAM103A1 Gene

Molecular function for FAM103A1 Gene

UniProtKB/Swiss-Prot Function: Required for efficient mRNA cap methylation. Regulates RNMT expression by a post-transcriptional stabilizing mechanism.

Gene Ontology (GO) - Molecular Function for FAM103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22099306
GO:0005515 protein binding IPI 22099306
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FAM103A1: view

Animal Model Products

CRISPR Products

miRNA for FAM103A1 Gene

miRTarBase miRNAs that target FAM103A1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM103A1 Gene

Localization for FAM103A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM103A1 Gene


Subcellular locations from

Jensen Localization Image for FAM103A1 Gene COMPARTMENTS Subcellular localization image for FAM103A1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FAM103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22099306
GO:0005845 mRNA cap binding complex IDA 22099306
genes like me logo Genes that share ontologies with FAM103A1: view

Pathways for FAM103A1 Gene

SuperPathways for FAM103A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM103A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006370 7-methylguanosine mRNA capping IDA 22099306
GO:0032259 methylation IMP 22099306
GO:0036031 recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex IDA 22099306
genes like me logo Genes that share ontologies with FAM103A1: view

No data available for Pathways by source for FAM103A1 Gene

Transcripts for FAM103A1 Gene

mRNA/cDNA for FAM103A1 Gene

(169) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM103A1 Gene

Family with sequence similarity 103, member A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM103A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM103A1 Gene

No ASD Table

Relevant External Links for FAM103A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM103A1 Gene

mRNA expression in normal human tissues for FAM103A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM103A1 Gene

SOURCE GeneReport for Unigene cluster for FAM103A1 Gene Hs.80624

genes like me logo Genes that share expressions with FAM103A1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM103A1 Gene

Orthologs for FAM103A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM103A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM103A1 35
  • 99.44 (n)
  • 99.15 (a)
FAM103A1 36
  • 99 (a)
(Bos Taurus)
Mammalia FAM103A1 35
  • 89.83 (n)
  • 92.37 (a)
MGC127733 36
  • 92 (a)
(Canis familiaris)
Mammalia FAM103A1 35
  • 91.24 (n)
  • 93.22 (a)
FAM103A1 36
  • 93 (a)
(Mus musculus)
Mammalia Fam103a1 35
  • 85.03 (n)
  • 87.29 (a)
Fam103a1 16
Fam103a1 36
  • 86 (a)
Gm10767 36
  • 82 (a)
Gm9830 36
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
-- 36
  • 84 (a)
-- 36
  • 77 (a)
-- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia FAM103A1 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Fam103a1 35
  • 84.18 (n)
  • 84.75 (a)
(Gallus gallus)
Aves FAM103A1 35
  • 69.05 (n)
  • 58.93 (a)
FAM103A1 36
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
-- 36
  • 53 (a)
Species with no ortholog for FAM103A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM103A1 Gene

Gene Tree for FAM103A1 (if available)
Gene Tree for FAM103A1 (if available)

Paralogs for FAM103A1 Gene Pseudogenes for FAM103A1 Gene

genes like me logo Genes that share paralogs with FAM103A1: view

No data available for Paralogs for FAM103A1 Gene

Variants for FAM103A1 Gene

Sequence variations from dbSNP and Humsavar for FAM103A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs35548710 -- 82,988,314(-) TTGCT(-/A)CTGTC intron-variant
rs137975089 -- 82,988,431(+) TGTTA(C/T)AAATA intron-variant
rs141519135 -- 82,988,175(+) AAATG(C/T)AAAAA intron-variant
rs149465238 -- 82,988,439(+) ATATT(C/T)GCATA intron-variant
rs150334698 -- 82,988,326(+) ACTCC(A/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM103A1 Gene

Variant ID Type Subtype PubMed ID
esv28659 CNV Loss 19812545

Relevant External Links for FAM103A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM103A1 Gene

Disorders for FAM103A1 Gene

No disorders were found for FAM103A1 Gene.

No data available for UniProtKB/Swiss-Prot for FAM103A1 Gene

Publications for FAM103A1 Gene

  1. RAM/Fam103a1 is required for mRNA cap methylation. (PMID: 22099306) Gonatopoulos-Pournatzis T. … Cowling V.H. (Mol. Cell 2011) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM103A1 Gene

Sources for FAM103A1 Gene

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