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FAM102B Gene

protein-coding   GIFtS: 42
GCID: GC01P109102

Family With Sequence Similarity 102, Member B

  Search for FAM102B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 102, Member B1 2
Sym-3 Homolog B (C. Elegans)1
SYM-3B2
Protein FAM102B2
Sym-3 Homolog B2

External Ids:    HGNC: 276371   Entrez Gene: 2846112   Ensembl: ENSG000001626367   UniProtKB: Q5T8I33   

Export aliases for FAM102B gene to outside databases

Previous GC identifers: GC01P108703 GC01P108904 GC01P106996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM102B Gene:
FAM102B (family with sequence similarity 102, member B) is a protein-coding gene. An important paralog of this gene is FAM102A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM102B gene promoter:
         HOXA9B   HOXA9   MEF-2   LCR-F1   Meis-1b   MEF-2A   Nkx6-1   aMEF-2   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM102B promoter sequence
   Search Chromatin IP Primers for FAM102B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM102B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

FAM102B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM102B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P109102:  view genomic region     (about GC identifiers)

Start:
109,102,711 bp from pter      End:
109,187,522 bp from pter
Size:
84,812 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F102B_HUMAN, Q5T8I3 (See protein sequence)
Recommended Name: Protein FAM102B  
Size: 360 amino acids; 39308 Da
Sequence caution: Sequence=AAI27899.2; Type=Erroneous initiation; Sequence=AAI40864.1; Type=Erroneous initiation;
Sequence=AAI40866.1; Type=Erroneous initiation; Sequence=AAI50531.1; Type=Erroneous initiation;
Secondary accessions: A1L1A1 B0QZ46 B0QZ47 Q68DH7
Alternative splicing: 2 isoforms:  Q5T8I3-1   Q5T8I3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM102B: NX_Q5T8I3

Explore proteomics data for FAM102B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM102B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010883.2  
    ENSEMBL proteins: 
     ENSP00000359052   ENSP00000386084  

    FAM102B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM102B

     
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    Search eBioscience for ELISAs for FAM102B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019448 NT-C2

    Graphical View of Domain Structure for InterPro Entry Q5T8I3

    ProtoNet protein and cluster: Q5T8I3

    UniProtKB/Swiss-Prot: F102B_HUMAN, Q5T8I3
    Similarity: Belongs to the FAM102 family


    Find genes that share domains with FAM102B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM102B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM102B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM102B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM102B

    miRNA
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    miRTarBase miRNAs that target FAM102B:
    hsa-mir-29c-3p (MIRT020374)

    Block miRNA regulation of human, mouse, rat FAM102B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM102B (see all 40):
    hsa-miR-323-3p hsa-miR-26a-2* hsa-miR-4307 hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-570 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidFAM102B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM102B

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    Clone
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    GenScript: all cDNA clones in your preferred vector: FAM102B (NM_001010883)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM102B
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM102B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    extracellular1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM102B
    Interactions:

        Search GeneGlobe Interaction Network for FAM102B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM102B (ENSP000003590524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM102B (F102B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM102B gene: 
    NM_001010883.2  

    Unigene Cluster for FAM102B:

    Family with sequence similarity 102, member B
    Hs.200230  [show with all ESTs]
    Unigene Representative Sequence: NM_001010883
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370035(uc010ouy.2) ENST00000405454 ENST00000483371
    miRNA
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    Block miRNA regulation of human, mouse, rat FAM102B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM102B (see all 40):
    hsa-miR-323-3p hsa-miR-26a-2* hsa-miR-4307 hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-570 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidFAM102B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM102B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM102B
    Clone
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    OriGene clones in human, mouse for FAM102B (see all 6)
    OriGene ORF clones in mouse, rat for FAM102B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM102B (NM_001010883)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM102B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM102B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM102B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM102B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM102B
      QuantiFast Probe-based Assays in human, mouse, rat FAM102B

    Additional mRNA sequence: 

    AK025203.1 AK094905.1 BC127898.1 BC140863.1 BC140865.1 BC150530.1 CR749397.1 

    8 DOTS entries:

    DT.100022814  DT.309615  DT.87016167  DT.100715844  DT.309616  DT.121453265  DT.75125270  DT.95147205 

    Selected AceView cDNA sequences (see all 120):

    CR593389 AW236589 BQ014744 CR622249 BM468096 AA372965 BE672014 AW196488 
    AW512596 BM468145 BM680063 CA424322 AK094905 BM549367 BX482256 AA996371 
    BM454000 BQ440389 BQ424749 BM478901 BM723901 AI566004 CA396709 AA766755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM102B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAATAAAA
    FAM102B Expression
    About this image

    FAM102B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM102B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200230
        Custom PCR Arrays for FAM102B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM102B
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    QuantiTect SYBR Green Assays in human, mouse, rat FAM102B
    QuantiFast Probe-based Assays in human, mouse, rat FAM102B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM102B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM102B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam102b1 , 5 family with sequence similarity 102, member B1, 5 89.63(n)1
    95.28(a)1
      3 (48.04 cM)5
    3297391  NM_001163567.11  NP_001157039.11 
     1089709975 
    chicken
    (Gallus gallus)
    Aves FAM102B1 family with sequence similarity 102, member B 81.08(n)
    85.01(a)
      768922  XM_001232082.3  XP_001232083.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAM102B6
    family with sequence similarity 102, member B
    82(a)
    1 ↔ 1
    GL343211.1(2280719-2319694)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam102b1 family with sequence similarity 102, member B 73.63(n)
    81.89(a)
      549525  NM_001016771.2  NP_001016771.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam102bb1 family with sequence similarity 102, member B, b 70.29(n)
    77.44(a)
      557909  NM_001044844.1  NP_001038309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86716
    --
    13(a)
    1 → many
    2L(21262963-21282514)
    worm
    (Caenorhabditis elegans)
    Secernentea sym-36
    Protein SYM-3, isoform b (sym-3) mRNA, complete cd...
    25(a)
    1 → many
    X(5776251-5778880) WBGene00006368


    ENSEMBL Gene Tree for FAM102B (if available)
    TreeFam Gene Tree for FAM102B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM102B gene
    FAM102A2  
    1 SIMAP similar gene for FAM102B using alignment to 1 protein entry:     F102B_HUMAN:
    FAM102A

    Find genes that share paralogs with FAM102B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM102B (see all 1385)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853781721,2
    C--109101009(+) TCTCCC/TTTTTC 1 -- us2k10--------
    rs1854093611,2
    --109102762(+) GGCGGC/TGGCGA 1 -- us2k10--------
    rs558334851,2
    C--109140957(+) TATCC-/AAAAAAA 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs113376301,2
    C--109145496(+) GTCTC-/AAAAAA 1 -- int1 trp32Minor allele frequency- A:0.25NA CSA 4
    rs170372951,2
    C,F,H--109176632(+) TTCACG/AATCTC 1 -- int19Minor allele frequency- A:0.05NA NS EA WA 798
    rs1902076141,2
    --109176740(+) TTTTCA/CATTGC 1 -- int10--------
    rs1138695171,2
    C--109177009(+) GAATCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2000660981,2
    C--109177009(+) TGAAT-/TTA   
       
    /TTTA
    TTTTT
    2 -- int1 cds10--------
    rs2010399241,2
    --109177011(+) TCTTT-/ATTTTT 1 -- int10--------
    rs121220361,2
    C--109177021(+) TTTTTA/TAATTT 1 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for FAM102B (109102711 - 109187522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM102B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1009643CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM102B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM102B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM102B           About GenesLikeMe

    Genetic Association Database (GAD): FAM102B

    Export disorders for FAM102B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM102B gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with FAM102B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284611 HGNC: 27637 AceView: LOC284611 Ensembl:ENSG00000162636 euGenes: HUgn284611
    ECgene: FAM102B H-InvDB: FAM102B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM102B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM102B gene:
    Search GeneIP for patents involving FAM102B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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