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FAM102A Gene

protein-coding   GIFtS: 46

GC09M129742
family with sequence similarity 102, member A
(Previous name: chromosome 9 open reading frame 132 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C9orf132)
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Aliases &
Descriptions
for FAM102A

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C230093N12Rik 2
C9orf132 2, 3
EEIG1 2, 3, 5
Eeig1 1
MGC50853 2
OTTHUMP00000022216 2
OTTHUMP00000162379 2
bA203J24.7 1, 2
Descriptions
Early estrogen-induced gene 1 protein 2, 3
chromosome 9 open reading frame 132 1
family with sequence similarity 102, member A 2
External Ids
HGNC: 314191
Entrez Gene: 3996652
UniProtKB: Q5T9C23
Ensembl: ENSG000001671067
Search outside databases for aliases for FAM102A gene

Previous GC identifer: GC09M127786

Summaries
for FAM102A

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: F102A_HUMAN, Q5T9C2
Function: May play a role in estrogen action

Genomic Location
for FAM102A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAM102A gene  

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC chromosome: 9

FAM102A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M129742:     (about GC identifiers)

Start:
 129,742,679 bp from pter
End:
 129,782,613 bp from pter
Size:
 39,935 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  

Proteins
for FAM102A

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: F102A_HUMAN, Q5T9C2 (See protein sequence)
Recommended Name: Protein FAM102A  
Size: 384 amino acids; 41785 Da
Secondary accessions: Q8TEL4
Alternative splicing: 2 isoforms:  Q5T9C2-1   Q5T9C2-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001030331.1  NP_976050.1  


    ENSEMBL proteins: 
    ENSP00000362176 ENSP00000344864 ENSP00000362187 ENSP00000300434 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (FAM102A)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for FAM102A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for FAM102A

    Assays for FAM102A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for FAM102A

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR019448 Oestrogen-resp_Fam102A/B_N


       GeneDecks  FAM102A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5T9C2

    ProtoNet protein and cluster: Q5T9C2

    UniProtKB/Swiss-Prot: F102A_HUMAN, Q5T9C2
    Similarity: Belongs to the FAM102 family

    Gene Function
    for FAM102A

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (FAM102A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001035254

                  Applied Biosystems Silencer® siRNAs for FAM102A

                  Sigma-Aldrich siRNA for FAM102A  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001035254
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001035254
                                     untagged cDNA clones in CMV expression vector (see all 3): AK074108 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001035254

    UniProtKB/Swiss-Prot: F102A_HUMAN, Q5T9C2
    Function: May play a role in estrogen action
    Induction: By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as
    by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen

    Pathways & Interactions
    for FAM102A

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    Drugs & Compounds
    for FAM102A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAM102A

    Transcripts
    for FAM102A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (FAM102A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001035254

                  Sigma-Aldrich siRNA for FAM102A  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001035254  NM_203305  

    REFSEQ mRNAs for FAM102A gene (2 alternative transcripts): 

    NM_001035254.1   NM_203305.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001035254  NM_203305  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001035254
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001035254
                                     untagged cDNA clones in CMV expression vector (see all 3): AK074108 

    Additional cDNA sequence: 

    AK058004.1 AK074108.1 AK094350.1 AL049365.1 BC047949.1 BC137087.1 BC137088.1 BC142952.1 

    10 DOTS entries:

    DT.97817759  DT.40292167  DT.100788647  DT.446857  DT.416621  DT.99999239  DT.95306624  DT.121158852 
    DT.86844224  DT.91764612 

    24/276 AceView cDNA sequences (see all 276 ):

    AA721310 BF062910 BI010997 AA677893 BF001256 Z38780 BM772883 AI223826 
    BQ890377 CB990054 BE737037 BM458600 AI820042 BF059477 CF541104 BF928829 
    AA828303 AA805418 AI273216 T12641 BM837470 BE895962 AA736739 AI674737 

    highest scoring ESTs for FAM102A:

    AA291292 AA457028 AA504636 AA521285 AA649919 AA731321 AA807123 AA825573 AA828303 AA831483 

    Unigene Cluster for FAM102A:

    Family with sequence similarity 102, member A
    Hs.568044  [show with all ESTs]
    Unigene Representative Sequence: AK074108


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM102A

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                      
    SP2:                                                      
    SP3:        -     -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for FAM102A

    4 Ensembl transcripts including schematic representations:
    ENST00000373084  ENST00000344808  ENST00000373095  ENST00000300434  

    Expression
    for FAM102A

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAM102A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAM102A

    1 / 2 / 3

    5 probe-sets matching FAM102A gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		34788_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL049365 0.80 1.00 0.91 1

    		212400_at2, 3 U133-A 1 1.00 1.00 -- -- AL043266 0.60 1.00 0.82 1

    		208162_s_at*2 U133-A 9 1.00 0.12 -- -- -- -- -- -- --

    		212400_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208162_s_at*2 U133Plus2 9 1.00 0.12 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGGGAGCCCT

    SOURCE GeneReport for Unigene cluster: Hs.568044

    Orthologs
    for FAM102A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for FAM102A gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LOC4913231   -- similar to early estrogen-induced gene 1 protein 90.8(n)
    95.9(a)    		 491323  XM_857463.1  XP_862556.1 
    chimpanzee
    (Pan troglodytes)    		 FAM102A1   -- family with sequence similarity 102, member A 95.92(n)
    95.05(a)    		 464760  XM_001152647.1  XP_001152647.1 
    cow
    (Bos taurus)    		 FAM102A1   -- early estrogen-induced gene 1 protein 91.56(n)
    96.34(a)    		 615907  XM_867838.2  XP_872931.2 
    mouse
    (Mus musculus)    		 Fam102a1, 5 25
    		 family with sequence similarity 102, member A1, 5 87.85(n)1
    96.35(a)1    		 989521  NM_153560.31  NP_705788.11 
     AI4264655  AK0490325  (see all 31)
    chicken
    (Gallus gallus)    		 FAM102A1   -- family with sequence similarity 102, member A 77.4(n)
    87.43(a)    		 417228  XM_415511.2  XP_415511.2 
    About this table        Species with no ortholog for FAM102A

    ENSEMBL Gene Tree for FAM102A

    Paralogs
    for FAM102A

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FAM102A gene
    FAM102B2  

    SNPs/Variants
    for FAM102A

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/222 NCBI SNPs in FAM102A are shown (see all 222 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 84)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs78591,2
    		A,C,F,H,O129743386(-) TTGGGT/CGGAAA 2 -- ut317Minor allele frequency- C:0.47MN EA EU WA 1536
    rs38023541,2
    		A,C,F,H129753437(-) TATCTG/ATCTCT 2 -- int1 ng314Minor allele frequency- A:0.40EU EA WA 416
    rs64788031,2
    		A,C,F,H129743610(+) CGAGCA/GAACAC 2 -- ut31 ese34Minor allele frequency- G:0.36EU EA WA 418
    rs48365951,2
    		A,C,F,H129754439(+) GAGGCA/GAAGGC 2 -- ng31 int11Minor allele frequency- G:0.07EU 120
    rs37398201,2
    		A,C,F,H129742360(-) AACTGT/CGCCTC 2 -- ng513Minor allele frequency- C:0.47EA WA 298
    --
    rs102172901,2
    		A,C,F,H129753530(+) TGCAGT/GGTTCA 2 -- int1 ng314Minor allele frequency- G:0.40EU EA WA 420
    rs38245271,2
    		A,C,F,H129742463(-) CATACG/AGAGCA 2 -- ng515Minor allele frequency- A:0.14EA EU WA 1338
    rs37398211,2
    		A,C,F,H129742298(-) ACCTGT/CAGGAG 2 -- ng514Minor allele frequency- C:0.43EU EA WA 418
    rs10430601,2
    		A,C,F,H129744941(-) GCAGCA/GGCTCC 2 -- ut31 ese36Minor allele frequency- N:0.02MN EA NA EU 508
    rs38185101,2
    		A,C,F,H129744796(+) GGAGGC/TGGTCT 2 -- ut31 ese36Minor allele frequency- N:0.00EA NA EU 1820
    About this table

    HapMap Linkage Disequilibrium images for FAM102A (up to first 250kb)

    Disorders & Mutations
    for FAM102A

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 610891

    Medical News
    for FAM102A

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for FAM102A

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		4 PubMed articles for FAM102A gene:

    Search for FAM102A

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM102A

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 399665 HGNC: 31419 AceView: MGC50853 Ensembl:ENSG00000167106 euGenes: HUgn399665
    ECgene: FAM102A H-InvDB: FAM102A

    Other Databases showing FAM102A

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing FAM102A

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for FAM102A

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for FAM102A

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAM102A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM102A-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAM102A Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for FAM102A

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