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Aliases for FAM102A Gene

Aliases for FAM102A Gene

  • Family With Sequence Similarity 102 Member A 2 3 5
  • Early Estrogen-Induced Gene 1 Protein 3 4
  • C9orf132 3 4
  • EEIG1 3 4
  • Family With Sequence Similarity 102, Member A 2
  • Chromosome 9 Open Reading Frame 132 2
  • Early Estrogen-Induced Gene 1 2
  • Sym-3 Homolog A (C. Elegans) 2
  • Protein FAM102A 3
  • Sym-3 Homolog A 3
  • C230093N12Rik 3
  • BA203J24.7 3
  • SYM-3A 3

External Ids for FAM102A Gene

Previous HGNC Symbols for FAM102A Gene

  • C9orf132

Previous GeneCards Identifiers for FAM102A Gene

  • GC09M127786
  • GC09M129742
  • GC09M130702
  • GC09M100319

Summaries for FAM102A Gene

GeneCards Summary for FAM102A Gene

FAM102A (Family With Sequence Similarity 102 Member A) is a Protein Coding gene. An important paralog of this gene is FAM102B.

UniProtKB/Swiss-Prot for FAM102A Gene

  • May play a role in estrogen action.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM102A Gene

Genomics for FAM102A Gene

Regulatory Elements for FAM102A Gene

Enhancers for FAM102A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F128000 1.7 FANTOM5 Ensembl ENCODE 12.7 -20.9 -20925 2.7 HDGF PKNOX1 ARNT CREB3L1 FEZF1 CBX5 GATA2 FOS JUNB REST PIP5KL1 FAM102A DPM2 LOC105376284 ENSG00000230848 NAIF1 SLC25A25 LOC101929270 SPOUT1 FAM129B
GH09F128004 1.7 FANTOM5 Ensembl ENCODE 11.5 -25.9 -25900 5.8 ATF1 ARID4B ZNF48 ZNF121 CBX5 FOS DEK ZNF263 NFYC PPARG LOC101929314 FAM102A PIP5KL1 LOC105376284 DPM2 SLC25A25 NAIF1 ENSG00000230848
GH09F128020 1.8 FANTOM5 Ensembl ENCODE 10.8 -46.4 -46446 13.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A YBX1 YY1 SLC30A9 CBX5 SNORA65 ZNF79 SPOUT1 CDK9 ENSG00000272696 ENSG00000272593 FAM102A SPTAN1 LOC101929314 COQ4
GH09F127951 1.3 Ensembl ENCODE 12.3 +26.5 26543 5.4 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 FOS DEK PIP5KL1 ZNF79 SPOUT1 FAM102A ENSG00000230848 CDK9 PTRH1 LCN2 C9orf16 CIZ1
GH09F127962 1.8 FANTOM5 Ensembl ENCODE 8.6 +7.7 7680 22.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 PIP5KL1 DPM2 SPOUT1 LOC101929270 LOC105376284 SLC25A25 NAIF1 ENSG00000230848 CDK9 PTRH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM102A on UCSC Golden Path with GeneCards custom track

Promoters for FAM102A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FAM102A Gene

127,940,579 bp from pter
127,981,027 bp from pter
40,449 bases
Minus strand

Genomic View for FAM102A Gene

Genes around FAM102A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM102A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM102A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM102A Gene

Proteins for FAM102A Gene

  • Protein details for FAM102A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM102A
    Protein Accession:
    Secondary Accessions:
    • A2A329
    • Q8TEL4

    Protein attributes for FAM102A Gene

    384 amino acids
    Molecular mass:
    41785 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI12618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM102A Gene


neXtProt entry for FAM102A Gene

Post-translational modifications for FAM102A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM102A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM102A Gene

Domains & Families for FAM102A Gene

Protein Domains for FAM102A Gene


Suggested Antigen Peptide Sequences for FAM102A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 NT-C2 domain.
  • Belongs to the FAM102 family.
  • Contains 1 NT-C2 domain.
  • Belongs to the FAM102 family.
genes like me logo Genes that share domains with FAM102A: view

No data available for Gene Families for FAM102A Gene

Function for FAM102A Gene

Molecular function for FAM102A Gene

UniProtKB/Swiss-Prot Function:
May play a role in estrogen action.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen.

Gene Ontology (GO) - Molecular Function for FAM102A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM102A: view
genes like me logo Genes that share phenotypes with FAM102A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM102A Gene

Localization for FAM102A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM102A gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM102A Gene

Pathways & Interactions for FAM102A Gene

SuperPathways for FAM102A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM102A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM102A Gene

Transcripts for FAM102A Gene

Unigene Clusters for FAM102A Gene

Family with sequence similarity 102, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM102A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP3: - - -

Relevant External Links for FAM102A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM102A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM102A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM102A Gene

This gene is overexpressed in Plasma (35.2), Pancreatic juice (14.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM102A Gene

Protein tissue co-expression partners for FAM102A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM102A Gene:


SOURCE GeneReport for Unigene cluster for FAM102A Gene:

genes like me logo Genes that share expression patterns with FAM102A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM102A Gene

Orthologs for FAM102A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM102A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM102A 34 35
  • 95.92 (n)
(Bos Taurus)
Mammalia FAM102A 34 35
  • 91.38 (n)
(Monodelphis domestica)
Mammalia FAM102A 35
  • 90 (a)
(Canis familiaris)
Mammalia FAM102A 34 35
  • 89.65 (n)
(Rattus norvegicus)
Mammalia Fam102a 34
  • 87.76 (n)
(Mus musculus)
Mammalia Fam102a 34 16 35
  • 87.07 (n)
(Ornithorhynchus anatinus)
Mammalia FAM102A 35
  • 87 (a)
(Gallus gallus)
Aves FAM102A 34 35
  • 76.7 (n)
(Anolis carolinensis)
Reptilia FAM102A 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam102a 34
  • 72.71 (n)
(Danio rerio)
Actinopterygii fam102ab 34 35
  • 70.66 (n)
fam102aa 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8671 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea sym-3 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
-- 35
  • 33 (a)
Species where no ortholog for FAM102A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM102A Gene

Gene Tree for FAM102A (if available)
Gene Tree for FAM102A (if available)

Paralogs for FAM102A Gene

Paralogs for FAM102A Gene

(1) SIMAP similar genes for FAM102A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM102A: view

Variants for FAM102A Gene

Sequence variations from dbSNP and Humsavar for FAM102A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10217290 -- 127,951,430(+) TGCAG(G/T)GTTCA intron-variant, upstream-variant-2KB
rs10283921 -- 127,951,570(+) cagca(C/T)tttgg intron-variant, upstream-variant-2KB
rs1043060 -- 127,942,841(-) GCAGC(A/G)GCTCC utr-variant-3-prime
rs10646906 -- 127,941,573(+) AGTAA(-/AAC)AACAA utr-variant-3-prime
rs10676299 -- 127,941,584(+) AACAA(-/CAA)ATGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM102A Gene

Variant ID Type Subtype PubMed ID
nsv951768 CNV deletion 24416366
nsv831727 CNV loss 17160897
nsv6722 CNV insertion 18451855
nsv615381 CNV loss 21841781
nsv478648 CNV novel sequence insertion 20440878
nsv476947 CNV novel sequence insertion 20440878
nsv466577 CNV loss 19166990
nsv1054891 CNV gain 25217958
esv5200 CNV loss 18987735
esv2739057 CNV deletion 23290073
esv2739056 CNV deletion 23290073

Variation tolerance for FAM102A Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM102A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM102A Gene

Disorders for FAM102A Gene

Relevant External Links for FAM102A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM102A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM102A Gene

Publications for FAM102A Gene

  1. Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. (PMID: 14605097) Wang D.Y. … Edwards E.A. (Mol. Endocrinol. 2004) 3 4 22 64
  2. Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. (PMID: 23478294) Choi H.K. … Lee S.Y. (Cell Res. 2013) 2 3 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim D.I. … Roux K.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FAM102A Gene

Sources for FAM102A Gene

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