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Aliases for FAM102A Gene

Aliases for FAM102A Gene

  • Family With Sequence Similarity 102 Member A 2 3 5
  • Early Estrogen-Induced Gene 1 Protein 3 4
  • C9orf132 3 4
  • EEIG1 3 4
  • Family With Sequence Similarity 102, Member A 2
  • Chromosome 9 Open Reading Frame 132 2
  • Early Estrogen-Induced Gene 1 2
  • Sym-3 Homolog A (C. Elegans) 2
  • Protein FAM102A 3
  • Sym-3 Homolog A 3
  • C230093N12Rik 3
  • BA203J24.7 3
  • SYM-3A 3

External Ids for FAM102A Gene

Previous HGNC Symbols for FAM102A Gene

  • C9orf132

Previous GeneCards Identifiers for FAM102A Gene

  • GC09M127786
  • GC09M129742
  • GC09M130702
  • GC09M100319

Summaries for FAM102A Gene

GeneCards Summary for FAM102A Gene

FAM102A (Family With Sequence Similarity 102 Member A) is a Protein Coding gene. An important paralog of this gene is FAM102B.

UniProtKB/Swiss-Prot for FAM102A Gene

  • May play a role in estrogen action.

Additional gene information for FAM102A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM102A Gene

Genomics for FAM102A Gene

GeneHancer (GH) Regulatory Elements for FAM102A Gene

Promoters and enhancers for FAM102A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I127962 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.6 +7.7 7679 22.2 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D FAM102A PIP5KL1 NAIF1 DPM2 ENSG00000272593 NUP188 ENSG00000227218 ZNF79 ODF2 GLE1
GH09I127946 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 550.3 +32.0 32018 5.2 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 NFYC PPARG KAT8 FAM102A PIP5KL1 DPM2 GC09P127942
GH09I127935 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 +43.7 43684 4.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF143 SP3 DPM2 PIP5KL1 ST6GALNAC6 AK1 FAM102A ENSG00000230848 ENSG00000227218
GH09I128000 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -20.9 -20925 2.7 HDGF PKNOX1 ATF1 ARNT SIN3A POLR2B ZNF766 GATA2 FOS ATF7 PIP5KL1 FAM102A DPM2 ENSG00000227218 ENSG00000230848 NAIF1 SLC25A25 FAM129B CDK9 TOR2A
GH09I128004 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -26.3 -26272 5.1 ATF1 SMAD1 ARID4B SIN3A ZNF48 NCOA2 ZNF766 ATF7 FOS RUNX3 LOC101929314 FAM102A PIP5KL1 ENSG00000227218 DPM2 SLC25A25 NAIF1 ENSG00000230848
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM102A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM102A gene promoter:

Genomic Locations for FAM102A Gene

Genomic Locations for FAM102A Gene
chr9:127,940,579-127,981,027
(GRCh38/hg38)
Size:
40,449 bases
Orientation:
Minus strand
chr9:130,702,858-130,742,812
(GRCh37/hg19)

Genomic View for FAM102A Gene

Genes around FAM102A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM102A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM102A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM102A Gene

Proteins for FAM102A Gene

  • Protein details for FAM102A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9C2-F102A_HUMAN
    Recommended name:
    Protein FAM102A
    Protein Accession:
    Q5T9C2
    Secondary Accessions:
    • A2A329
    • Q8TEL4

    Protein attributes for FAM102A Gene

    Size:
    384 amino acids
    Molecular mass:
    41785 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI12618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM102A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM102A Gene

Post-translational modifications for FAM102A Gene

No Post-translational modifications

Other Protein References for FAM102A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM102A Gene

Domains & Families for FAM102A Gene

Gene Families for FAM102A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM102A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM102A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T9C2

UniProtKB/Swiss-Prot:

F102A_HUMAN :
  • Belongs to the FAM102 family.
Family:
  • Belongs to the FAM102 family.
genes like me logo Genes that share domains with FAM102A: view

Function for FAM102A Gene

Molecular function for FAM102A Gene

UniProtKB/Swiss-Prot Function:
May play a role in estrogen action.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen.

Phenotypes From GWAS Catalog for FAM102A Gene

Gene Ontology (GO) - Molecular Function for FAM102A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM102A: view
genes like me logo Genes that share phenotypes with FAM102A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM102A Gene

Localization for FAM102A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM102A gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM102A Gene

Pathways & Interactions for FAM102A Gene

SuperPathways for FAM102A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM102A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM102A Gene

Drugs & Compounds for FAM102A Gene

No Compound Related Data Available

Transcripts for FAM102A Gene

Unigene Clusters for FAM102A Gene

Family with sequence similarity 102, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM102A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:
SP3: - - -

Relevant External Links for FAM102A Gene

GeneLoc Exon Structure for
FAM102A
ECgene alternative splicing isoforms for
FAM102A

Expression for FAM102A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM102A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM102A Gene

This gene is overexpressed in Plasma (35.2), Pancreatic juice (14.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM102A Gene



Protein tissue co-expression partners for FAM102A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM102A Gene:

FAM102A

SOURCE GeneReport for Unigene cluster for FAM102A Gene:

Hs.535972

Evidence on tissue expression from TISSUES for FAM102A Gene

  • Nervous system(3.6)
  • Pancreas(3)
genes like me logo Genes that share expression patterns with FAM102A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM102A Gene

Orthologs for FAM102A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM102A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM102A 33 34
  • 95.92 (n)
cow
(Bos Taurus)
Mammalia FAM102A 33 34
  • 91.38 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM102A 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM102A 33 34
  • 89.65 (n)
rat
(Rattus norvegicus)
Mammalia Fam102a 33
  • 87.76 (n)
mouse
(Mus musculus)
Mammalia Fam102a 33 16 34
  • 87.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM102A 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM102A 33 34
  • 76.7 (n)
lizard
(Anolis carolinensis)
Reptilia FAM102A 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam102a 33
  • 72.71 (n)
zebrafish
(Danio rerio)
Actinopterygii fam102ab 33 34
  • 70.66 (n)
fam102aa 34
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8671 34
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sym-3 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
Species where no ortholog for FAM102A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM102A Gene

ENSEMBL:
Gene Tree for FAM102A (if available)
TreeFam:
Gene Tree for FAM102A (if available)

Paralogs for FAM102A Gene

Paralogs for FAM102A Gene

(1) SIMAP similar genes for FAM102A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM102A: view

Variants for FAM102A Gene

Sequence variations from dbSNP and Humsavar for FAM102A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000088271 -- 127,941,245(-) T/C 3_prime_UTR_variant
rs1000166791 -- 127,976,645(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000167045 -- 127,941,066(-) T/C 3_prime_UTR_variant
rs1000327857 -- 127,973,500(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000369572 -- 127,957,943(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM102A Gene

Variant ID Type Subtype PubMed ID
esv2739056 CNV deletion 23290073
esv2739057 CNV deletion 23290073
esv5200 CNV loss 18987735
nsv1054891 CNV gain 25217958
nsv466577 CNV loss 19166990
nsv476947 CNV novel sequence insertion 20440878
nsv478648 CNV novel sequence insertion 20440878
nsv615381 CNV loss 21841781
nsv6722 CNV insertion 18451855
nsv831727 CNV loss 17160897
nsv951768 CNV deletion 24416366

Variation tolerance for FAM102A Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM102A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM102A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM102A Gene

Disorders for FAM102A Gene

Additional Disease Information for FAM102A

No disorders were found for FAM102A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM102A Gene

Publications for FAM102A Gene

  1. Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. (PMID: 14605097) Wang DY … Edwards EA (Molecular endocrinology (Baltimore, Md.) 2004) 3 4 22 58
  2. Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. (PMID: 23478294) Choi HK … Lee SY (Cell research 2013) 2 3 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim DI … Roux KJ (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58

Products for FAM102A Gene

Sources for FAM102A Gene

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