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Aliases for FAM102A Gene

Aliases for FAM102A Gene

  • Family With Sequence Similarity 102, Member A 2 3
  • Early Estrogen-Induced Gene 1 Protein 3 4
  • C9orf132 3 4
  • EEIG1 3 4
  • Chromosome 9 Open Reading Frame 132 2
  • Sym-3 Homolog A (C. Elegans) 2
  • Sym-3 Homolog A 3
  • C230093N12Rik 3
  • BA203J24.7 3
  • SYM-3A 3

External Ids for FAM102A Gene

Previous HGNC Symbols for FAM102A Gene

  • C9orf132

Previous GeneCards Identifiers for FAM102A Gene

  • GC09M127786
  • GC09M129742
  • GC09M130702
  • GC09M100319

Summaries for FAM102A Gene

GeneCards Summary for FAM102A Gene

FAM102A (Family With Sequence Similarity 102, Member A) is a Protein Coding gene. An important paralog of this gene is FAM102B.

UniProtKB/Swiss-Prot for FAM102A Gene

  • May play a role in estrogen action.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM102A Gene

Genomics for FAM102A Gene

Regulatory Elements for FAM102A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM102A Gene

127,940,579 bp from pter
127,981,027 bp from pter
40,449 bases
Minus strand

Genomic View for FAM102A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM102A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM102A Gene

Proteins for FAM102A Gene

  • Protein details for FAM102A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM102A
    Protein Accession:
    Secondary Accessions:
    • A2A329
    • Q8TEL4

    Protein attributes for FAM102A Gene

    384 amino acids
    Molecular mass:
    41785 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI12618.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM102A Gene


neXtProt entry for FAM102A Gene

Proteomics data for FAM102A Gene at MOPED

Post-translational modifications for FAM102A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM102A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM102A Gene

Domains & Families for FAM102A Gene

Protein Domains for FAM102A Gene


Suggested Antigen Peptide Sequences for FAM102A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM102 family.
  • Belongs to the FAM102 family.
genes like me logo Genes that share domains with FAM102A: view

No data available for Gene Families for FAM102A Gene

Function for FAM102A Gene

Molecular function for FAM102A Gene

UniProtKB/Swiss-Prot Function:
May play a role in estrogen action.
UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen

Gene Ontology (GO) - Molecular Function for FAM102A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM102A: view

Phenotypes for FAM102A Gene

GenomeRNAi human phenotypes for FAM102A:
genes like me logo Genes that share phenotypes with FAM102A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM102A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM102A Gene

Localization for FAM102A Gene

Subcellular locations from

Jensen Localization Image for FAM102A Gene COMPARTMENTS Subcellular localization image for FAM102A gene
Compartment Confidence
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM102A Gene

Pathways & Interactions for FAM102A Gene

SuperPathways for FAM102A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM102A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM102A Gene

Drugs & Compounds for FAM102A Gene

No Compound Related Data Available

Transcripts for FAM102A Gene

Unigene Clusters for FAM102A Gene

Family with sequence similarity 102, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM102A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM102A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP3: - - -

Relevant External Links for FAM102A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM102A Gene

mRNA expression in normal human tissues for FAM102A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM102A Gene

This gene is overexpressed in Plasma (35.2), Pancreatic juice (14.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM102A Gene

SOURCE GeneReport for Unigene cluster for FAM102A Gene Hs.535972

genes like me logo Genes that share expression patterns with FAM102A: view

Protein tissue co-expression partners for FAM102A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM102A Gene

Orthologs for FAM102A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM102A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM102A 35
  • 91.38 (n)
  • 95.82 (a)
FAM102A 36
  • 96 (a)
(Canis familiaris)
Mammalia FAM102A 35
  • 89.65 (n)
  • 93.95 (a)
FAM102A 36
  • 96 (a)
(Mus musculus)
Mammalia Fam102a 35
  • 87.07 (n)
  • 94.53 (a)
Fam102a 16
Fam102a 36
  • 93 (a)
(Pan troglodytes)
Mammalia FAM102A 35
  • 95.92 (n)
  • 95.05 (a)
FAM102A 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Fam102a 35
  • 87.76 (n)
  • 95.05 (a)
(Monodelphis domestica)
Mammalia FAM102A 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia FAM102A 36
  • 87 (a)
(Gallus gallus)
Aves FAM102A 35
  • 76.7 (n)
  • 85.86 (a)
FAM102A 36
  • 86 (a)
(Anolis carolinensis)
Reptilia FAM102A 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam102a 35
  • 72.71 (n)
  • 78.93 (a)
(Danio rerio)
Actinopterygii fam102ab 35
  • 70.66 (n)
  • 75.52 (a)
fam102aa 36
  • 58 (a)
fam102ab 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8671 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea sym-3 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
-- 36
  • 33 (a)
Species with no ortholog for FAM102A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM102A Gene

Gene Tree for FAM102A (if available)
Gene Tree for FAM102A (if available)

Paralogs for FAM102A Gene

Paralogs for FAM102A Gene

(1) SIMAP similar genes for FAM102A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM102A: view

Variants for FAM102A Gene

Sequence variations from dbSNP and Humsavar for FAM102A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs734793 -- 127,969,431(-) AGGGC(A/C)GTTAT intron-variant
rs943391 -- 127,972,538(-) gctgc(C/T)ggtgc intron-variant, reference, missense
rs943392 -- 127,963,162(-) CAACT(C/T)TTGGA intron-variant
rs1043060 -- 127,942,841(-) GCAGC(A/G)GCTCC utr-variant-3-prime
rs1078697 -- 127,974,971(+) TCAGC(C/T)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM102A Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
dgv8291n71 CNV Loss 21882294
dgv8293n71 CNV Loss 21882294
nsv466577 CNV Loss 19166990
nsv6722 CNV Insertion 18451855
nsv831727 CNV Loss 17160897
esv2739056 CNV Deletion 23290073
esv5200 CNV Deletion 18987735
esv2739057 CNV Deletion 23290073

Variation tolerance for FAM102A Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM102A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM102A Gene

Disorders for FAM102A Gene

Relevant External Links for FAM102A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM102A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM102A Gene

Publications for FAM102A Gene

  1. Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. (PMID: 14605097) Wang D.Y. … Edwards E.A. (Mol. Endocrinol. 2004) 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. (PMID: 23478294) Choi H.K. … Lee S.Y. (Cell Res. 2013) 67
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for FAM102A Gene

Sources for FAM102A Gene

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