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Aliases for FAM101B Gene

Aliases for FAM101B Gene

  • Family With Sequence Similarity 101 Member B 2 3 5
  • Family With Sequence Similarity 101, Member B 2 3
  • Regulator Of Filamin Protein B 3 4
  • Protein FAM101B 3 4
  • RefilinB 3 4
  • CFM1 3

External Ids for FAM101B Gene

Previous GeneCards Identifiers for FAM101B Gene

  • GC17M000294

Summaries for FAM101B Gene

GeneCards Summary for FAM101B Gene

FAM101B (Family With Sequence Similarity 101 Member B) is a Protein Coding gene. GO annotations related to this gene include filamin binding. An important paralog of this gene is FAM101A.

UniProtKB/Swiss-Prot for FAM101B Gene

  • Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM101B Gene

Genomics for FAM101B Gene

Regulatory Elements for FAM101B Gene

Enhancers for FAM101B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM101B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM101B Gene

439,978 bp from pter
445,940 bp from pter
5,963 bases
Minus strand

Genomic View for FAM101B Gene

Genes around FAM101B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM101B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM101B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM101B Gene

Proteins for FAM101B Gene

  • Protein details for FAM101B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Filamin-interacting protein FAM101B
    Protein Accession:

    Protein attributes for FAM101B Gene

    214 amino acids
    Molecular mass:
    22882 Da
    Quaternary structure:
    • Interacts with FLNA and FLNB.

neXtProt entry for FAM101B Gene

Proteomics data for FAM101B Gene at MOPED

Post-translational modifications for FAM101B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM101B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM101B Gene

Domains & Families for FAM101B Gene

Protein Domains for FAM101B Gene


Suggested Antigen Peptide Sequences for FAM101B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM101 family.
  • Belongs to the FAM101 family.
genes like me logo Genes that share domains with FAM101B: view

No data available for Gene Families for FAM101B Gene

Function for FAM101B Gene

Molecular function for FAM101B Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.
genes like me logo Genes that share phenotypes with FAM101B: view

Animal Models for FAM101B Gene

MGI Knock Outs for FAM101B:

Animal Model Products

CRISPR Products

miRNA for FAM101B Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM101B Gene

Localization for FAM101B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM101B Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with FLNA along actin bundle-like structures. {ECO:0000250 UniProtKB:Q5SVD0}.

Subcellular locations from

Jensen Localization Image for FAM101B Gene COMPARTMENTS Subcellular localization image for FAM101B gene
Compartment Confidence
cytoskeleton 3
cytosol 2
extracellular 2
plasma membrane 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FAM101B Gene

Pathways & Interactions for FAM101B Gene

SuperPathways for FAM101B Gene

No Data Available

Interacting Proteins for FAM101B Gene

Gene Ontology (GO) - Biological Process for FAM101B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048705 skeletal system morphogenesis IEA --
GO:0061572 actin filament bundle organization IEA --
GO:1900158 negative regulation of bone mineralization involved in bone maturation IEA --
genes like me logo Genes that share ontologies with FAM101B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM101B Gene

Drugs & Compounds for FAM101B Gene

No Compound Related Data Available

Transcripts for FAM101B Gene

mRNA/cDNA for FAM101B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM101B Gene

Family with sequence similarity 101, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM101B Gene

No ASD Table

Relevant External Links for FAM101B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM101B Gene

mRNA expression in normal human tissues for FAM101B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM101B Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for FAM101B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM101B Gene

SOURCE GeneReport for Unigene cluster for FAM101B Gene Hs.345588

genes like me logo Genes that share expression patterns with FAM101B: view

Protein tissue co-expression partners for FAM101B Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM101B Gene

Orthologs for FAM101B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM101B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM101B 35
  • 85.9 (n)
  • 84.62 (a)
FAM101B 36
  • 65 (a)
(Canis familiaris)
Mammalia FAM101B 35
  • 85.2 (n)
  • 84.11 (a)
FAM101B 36
  • 58 (a)
(Mus musculus)
Mammalia Fam101b 35
  • 81.62 (n)
  • 80.37 (a)
Fam101b 16
Fam101b 36
  • 56 (a)
(Pan troglodytes)
Mammalia FAM101B 35
  • 98.35 (n)
  • 97.16 (a)
FAM101B 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fam101b 35
  • 81 (n)
  • 79.91 (a)
(Monodelphis domestica)
Mammalia FAM101B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FAM101B 36
  • 71 (a)
(Gallus gallus)
Aves FAM101B 35
  • 69.78 (n)
  • 62.62 (a)
FAM101B 36
  • 46 (a)
(Anolis carolinensis)
Reptilia FAM101B 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam101b 35
  • 66.34 (n)
  • 64.56 (a)
(Danio rerio)
Actinopterygii fam101b 35
  • 61.9 (n)
  • 56.3 (a)
fam101b 36
  • 34 (a)
Species with no ortholog for FAM101B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM101B Gene

Gene Tree for FAM101B (if available)
Gene Tree for FAM101B (if available)

Paralogs for FAM101B Gene

Paralogs for FAM101B Gene

(1) SIMAP similar genes for FAM101B Gene using alignment to 3 proteins: Pseudogenes for FAM101B Gene

genes like me logo Genes that share paralogs with FAM101B: view

Variants for FAM101B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM101B Gene

Variant ID Type Subtype PubMed ID
nsv907452 CNV Gain 21882294
nsv457627 CNV Gain 19166990
esv2422420 CNV Duplication 17116639
nsv827849 CNV Gain 20364138
nsv522031 CNV Gain 19592680

Variation tolerance for FAM101B Gene

Gene Damage Index Score: 4.35; 63.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for FAM101B Gene

Disorders for FAM101B Gene

Relevant External Links for FAM101B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM101B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM101B Gene

Publications for FAM101B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. (PMID: 21709252) Gay O. … Baudier J. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for FAM101B Gene

Sources for FAM101B Gene