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FAM101B Gene

protein-coding   GIFtS: 38

GC17M000294
family with sequence similarity 101, member B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC45871 1, 2
Descriptions
family with sequence similarity 101, member B 2
hypothetical protein LOC359845 2
External Ids
HGNC: 287051
Entrez Gene: 3598452
UniProtKB: Q8N5W93
Ensembl: ENSG000001836887
Search outside databases for aliases for FAM101B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAM101B gene  

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

FAM101B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000294:     (about GC identifiers)

Start:
289,997 bp from pter
End:
295,959 bp from pter
Size:
5,963 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_024972.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: F101B_HUMAN, Q8N5W9 (See protein sequence)
Recommended Name: Protein FAM101B  
Size: 214 amino acids; 22882 Da

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_874364.1  

    ENSEMBL proteins: 
    ENSP00000331915 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for FAM101B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for FAM101B

    Assays for FAM101B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N5W9

    UniProtKB/Swiss-Prot: F101B_HUMAN, Q8N5W9
    Similarity: Belongs to the FAM101 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM101B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC031341

                  Applied Biosystems Silencer® siRNAs for FAM101B

                  Sigma-Aldrich siRNA for FAM101B  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAM101B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_182705
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_182705
                                     untagged cDNA clone in CMV expression vector: NM_182705 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_182705

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fam101b):

    normal

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for FAM101B (Q8N5W92) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT5Q929932MINT-64913
    PPP1R16AQ96I342MINT-65184
    TNFRSF10CO147982MINT-63078
    --Q8TAL42MINT-64912
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAM101B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAM101B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC031341

                  Sigma-Aldrich siRNA for FAM101B  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_182705  

    REFSEQ mRNAs for FAM101B gene: 

    NM_182705.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_182705  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_182705
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_182705
                                     untagged cDNA clone in CMV expression vector: NM_182705 

    Additional cDNA sequence: 

    BC014203.2 BC031341.1 

    4 DOTS entries:

    DT.95264420  DT.100022157  DT.100746101  DT.100699157 

    24/126 AceView cDNA sequences (see all 126 ):

    AI589914 BE909520 AA927591 AI401564 AA861036 AI074811 BF591441 AI382308 
    BM840481 AA046820 AW028411 AI087002 BE672956 AI077885 AA782653 BQ081940 
    BC014203 AI809021 AA046803 BU618199 BM757758 AI887004 BM836294 H99195 

    highest scoring ESTs for FAM101B:

    AA306090 AI589914 AL520769 BC031341 BE883780 BG938559 BU501968 BX374817 CB989042 CB989467 

    Unigene Clusters for FAM101B:

    Family with sequence similarity 101, member B
    Hs.345588  [show with all ESTs], Hs.596411  [show with all ESTs], Hs.719324  [show with all ESTs]
    Unigene Representative Sequences: AK093557, BX091250, NM_182705


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000329099  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAM101B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAM101B

    1 / 2 / 3

    6 probe-sets matching FAM101B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    59095_at2, 3 U95-B 1 1.00 1.00 0.98 1.11 N36764 0.80 1.00 0.91 1
    57616_at2, 3 U95-B 1 1.00 1.00 0.85 0.89 AI589914 0.80 1.00 0.91 1

    226876_at2, 3 U133-B 1 1.00 1.00 -- -- AI961778 0.60 1.00 0.82 1

    226905_at2, 3 U133-B 1 1.00 1.00 -- -- BG036514 0.40 1.00 0.76 1

    226876_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    226905_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FAM101B for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.345588 Hs.596411 Hs.719324
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FAM101B gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6112141   -- hypothetical protein LOC611214 88.11(n)
    88.26(a)
    611214  XM_848851.1  XP_853944.1 
    chimpanzee
    (Pan troglodytes)
    LOC4544011   -- similar to Family with sequence similarity 101, member more 98.38(n)
    97.22(a)
    454401  XM_511242.2  XP_511242.2 
    rat
    (Rattus norvegicus)
    Fam101b1   -- family with sequence similarity 101, member B 84.35(n)
    84.04(a)
    287534  NM_001007611.1  NP_001007612.1 
    mouse
    (Mus musculus)
    Fam101b1, 5 115
    family with sequence similarity 101, member B1, 5 85.13(n)1
    84.98(a)1
    765661  XM_893392.31  XP_898485.21 
     AA0305665  AK0051645  (see all 12)
    chicken
    (Gallus gallus)
    FAM101B1   -- family with sequence similarity 101, member B 74.37(n)
    68.4(a)
    417623  XM_415867.2  XP_415867.2 
    About this table        Species with no ortholog for FAM101B

    ENSEMBL Gene Tree for FAM101B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FAM101B gene
    FAM101A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/50 NCBI SNPs in FAM101B are shown (see all 50 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 21)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs32013931,2
    A,C,F,H290688(-) CTTTGC/AACACC 1 -- ut3112Minor allele frequency- A:0.39MN EU EA WA NA 1162
    rs80782731,2
    C,F,H292204(+) GCTTCC/TTGTCC 1 -- ut314Minor allele frequency- T:0.04EU EA WA 416
    rs127761,2
    C,F,H290590(+) TTTCAG/CACTCT 1 -- ut319Minor allele frequency- C:0.37MN NA EU EA WA 908
    --
    rs39244871,2
    C,F296670(-) GGTGAA/GGTGAG 1 -- ng313Minor allele frequency- G:0.44NA 140
    rs99087791,2
    A,C289936(+) AGCTGC/TTTTTC 1 -- ng510--------
    rs130721,2
    C,F290598(+) TCTCTA/CCACAC 1 -- ut312Minor allele frequency- C:0.50MN 372
    --
    rs124510731,2
    C292550(+) TTTTTA/TAAAAA 1 -- ut310--------
    --
    rs72233371,2
    C290780(+) GGGCAA/GAGCAA 1 -- ut310--------
    --
    rs72200331,2
    A291060(+) tccatC/Gtcaaa 1 -- ut310--------
    --
    rs99021421,2
    C296005(+) CATTTC/TTTTTA 1 -- ng31 tfbs30--------
    About this table

    HapMap Linkage Disequilibrium images for FAM101B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    4 PubMed articles for FAM101B gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 359845 HGNC: 28705 AceView: MGC45871 Ensembl:ENSG00000183688 euGenes: HUgn359845
    ECgene: FAM101B H-InvDB: FAM101B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAM101B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM101B-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAM101B Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for FAM101B

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