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Aliases for FAM101B Gene

Aliases for FAM101B Gene

  • Family With Sequence Similarity 101, Member B 2 3
  • Regulator Of Filamin Protein B 3 4
  • Protein FAM101B 3 4
  • RefilinB 3 4
  • Filamin-Interacting Protein FAM101B 3
  • CFM1 3

External Ids for FAM101B Gene

Previous GeneCards Identifiers for FAM101B Gene

  • GC17M000294

Summaries for FAM101B Gene

GeneCards Summary for FAM101B Gene

FAM101B (Family With Sequence Similarity 101, Member B) is a Protein Coding gene. GO annotations related to this gene include filamin binding. An important paralog of this gene is ZNF664-FAM101A.

UniProtKB/Swiss-Prot for FAM101B Gene

  • Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM101B Gene

Genomics for FAM101B Gene

Regulatory Elements for FAM101B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM101B Gene

Start:
439,978 bp from pter
End:
445,940 bp from pter
Size:
5,963 bases
Orientation:
Minus strand

Genomic View for FAM101B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM101B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM101B Gene

Proteins for FAM101B Gene

  • Protein details for FAM101B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5W9-F101B_HUMAN
    Recommended name:
    Filamin-interacting protein FAM101B
    Protein Accession:
    Q8N5W9
    Secondary Accessions:

    Protein attributes for FAM101B Gene

    Size:
    214 amino acids
    Molecular mass:
    22882 Da
    Quaternary structure:
    • Interacts with FLNA and FLNB.

neXtProt entry for FAM101B Gene

Proteomics data for FAM101B Gene at MOPED

Post-translational modifications for FAM101B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM101B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM101B Gene

Domains for FAM101B Gene

Protein Domains for FAM101B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM101B Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5W9

UniProtKB/Swiss-Prot:

F101B_HUMAN :
  • Q8N5W9
Family:
  • Belongs to the FAM101 family.
genes like me logo Genes that share domains with FAM101B: view

No data available for Gene Families for FAM101B Gene

Function for FAM101B Gene

Molecular function for FAM101B Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.

Gene Ontology (GO) - Molecular Function for FAM101B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031005 filamin binding IDA 21709252
genes like me logo Genes that share ontologies with FAM101B: view

Phenotypes for FAM101B Gene

MGI mutant phenotypes for FAM101B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FAM101B: view

Animal Model Products

CRISPR Products

miRNA for FAM101B Gene

miRTarBase miRNAs that target FAM101B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM101B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM101B Gene

Localization for FAM101B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM101B Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with FLNA along actin bundle-like structures. {ECO:0000250 UniProtKB:Q5SVD0}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM101B Gene COMPARTMENTS Subcellular localization image for FAM101B gene
Compartment Confidence
cytoskeleton 2
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM101B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM101B: view

Pathways for FAM101B Gene

SuperPathways for FAM101B Gene

No Data Available

Interacting Proteins for FAM101B Gene

Gene Ontology (GO) - Biological Process for FAM101B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with FAM101B: view

No data available for Pathways by source for FAM101B Gene

Transcripts for FAM101B Gene

mRNA/cDNA for FAM101B Gene

(126) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM101B Gene

Family with sequence similarity 101, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM101B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM101B Gene

No ASD Table

Relevant External Links for FAM101B Gene

GeneLoc Exon Structure for
FAM101B
ECgene alternative splicing isoforms for
FAM101B

Expression for FAM101B Gene

mRNA expression in normal human tissues for FAM101B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM101B Gene

This gene is overexpressed in Whole Blood (11.0).

Protein differential expression in normal tissues for FAM101B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM101B Gene

SOURCE GeneReport for Unigene cluster for FAM101B Gene Hs.345588

genes like me logo Genes that share expressions with FAM101B: view

Expression partners for FAM101B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM101B Gene

Orthologs for FAM101B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM101B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM101B 35
  • 85.9 (n)
  • 84.62 (a)
FAM101B 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM101B 35
  • 85.2 (n)
  • 84.11 (a)
FAM101B 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam101b 35
  • 81.62 (n)
  • 80.37 (a)
Fam101b 16
Fam101b 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM101B 35
  • 98.35 (n)
  • 97.16 (a)
FAM101B 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam101b 35
  • 81 (n)
  • 79.91 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM101B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM101B 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM101B 35
  • 69.78 (n)
  • 62.62 (a)
FAM101B 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM101B 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam101b 35
  • 66.34 (n)
  • 64.56 (a)
zebrafish
(Danio rerio)
Actinopterygii fam101b 35
  • 61.9 (n)
  • 56.3 (a)
fam101b 36
  • 34 (a)
OneToOne
Species with no ortholog for FAM101B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM101B Gene

ENSEMBL:
Gene Tree for FAM101B (if available)
TreeFam:
Gene Tree for FAM101B (if available)

Paralogs for FAM101B Gene

Paralogs for FAM101B Gene

Selected SIMAP similar genes for FAM101B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAM101B Gene

genes like me logo Genes that share paralogs with FAM101B: view

Variants for FAM101B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM101B Gene

Variant ID Type Subtype PubMed ID
nsv907452 CNV Gain 21882294
nsv457627 CNV Gain 19166990
esv2422420 CNV Duplication 17116639
nsv827849 CNV Gain 20364138
nsv522031 CNV Gain 19592680

Relevant External Links for FAM101B Gene

HapMap Linkage Disequilibrium report
FAM101B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FAM101B Gene

Disorders for FAM101B Gene

No disorders were found for FAM101B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FAM101B Gene

Publications for FAM101B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for FAM101B Gene

Sources for FAM101B Gene

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