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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM101B Gene

protein-coding   GIFtS: 39
GCID: GC17M000294

family with sequence similarity 101, member B
  Search for FAM101B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM101B    

Aliases
for FAM101B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 101, Member B1 2
MGC458711
Protein FAM101B2

External Ids:    HGNC: 287051   Entrez Gene: 3598452   Ensembl: ENSG000001836887   UniProtKB: Q8N5W93   

Export aliases for FAM101B gene to outside databases


Summaries
for FAM101B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM101B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_024972.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM101B gene promoter:
         GR   NCX/Ncx   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   GATA-6   Pax-2b   GR-alpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM101B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM101B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM101B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

FAM101B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM101B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000294:  view genomic region     (about GC identifiers)

Start:
 289,769 bp from pter      End:
 295,732 bp from pter
Size:
 5,964 bases      Orientation:
 minus strand

1 alternative location:
Chr17-,PATCHES 289,769-295,732     

Proteins
for FAM101B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F101B_HUMAN, Q8N5W9 (See protein sequence)
Recommended Name: Protein FAM101B  
Size: 214 amino acids; 22882 Da

Explore the universe of human proteins at neXtProt for FAM101B: NX_Q8N5W9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N5W9

    • FAM101B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_874364.1  
    ENSEMBL proteins: 
     ENSP00000331915  

    Human Recombinant Protein Products: 
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    Uscn Proteins for FAM101B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015629actin cytoskeleton IEA--


    FAM101B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FAM101B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N5W9

    UniProtKB/Swiss-Prot: F101B_HUMAN, Q8N5W9
    Similarity: Belongs to the FAM101 family


    Function
    for FAM101B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM101B
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    SwitchGear 3'UTR luciferase reporter plasmid: FAM101B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031005filamin binding IDA--


    FAM101B for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fam101b):
     normal 

    FAM101B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FAM101B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM101B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for FAM101B (Q8N5W92, 3 ENSP000003319154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I342, 3, ENSP000002925394MINT-65184 I2D: score=4 STRING: ENSP00000292539
    KAT5Q929932, 3MINT-64913 I2D: score=5 
    TNFRSF10CO147982, 3MINT-63078 I2D: score=5 
    ZBTB16Q055162, 3MINT-64912 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition IEA--
    GO:0030036actin cytoskeleton organization IEA--


    FAM101B for ontologies           About GeneDecksing



    Drugs & Compounds
    for FAM101B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM101B
    Search CenterWatch for drugs/clinical trials and news about FAM101B / F101B 

    Transcripts
    for FAM101B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAM101B gene: 
    NM_182705.2  

    Unigene Clusters for FAM101B:

    Family with sequence similarity 101, member B
    Hs.345588  [show with all ESTs], Hs.723693  [show with all ESTs], Hs.741149  [show with all ESTs]
    Unigene Representative Sequences: AK093557, BX091250, NM_182705
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329099(uc002frj.3)

    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM101B (see all 31):
    hsa-miR-26a-2* hsa-miR-19b-2* hsa-miR-330-5p hsa-miR-2110 hsa-miR-15a hsa-miR-202 hsa-miR-29c hsa-miR-29a
    SwitchGear 3'UTR luciferase reporter plasmid: FAM101B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM101B (see all 4)
    OriGene shRNA RFP: FAM101B
    OriGene siRNA: FAM101B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM101B
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM101B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM101B

    Additional cDNA sequence: 

    BC014203.2 BC031341.1 

    5 DOTS entries:

    DT.95264420  DT.100022157  DT.100746101  DT.100699157  DT.97836808 

    24/126 AceView cDNA sequences (see all 126):

    BQ081940 BM840481 BE909520 AI589914 AI809021 BU618199 AA046803 AA782653 
    AA861036 AI401564 AI074811 AI077885 BF591441 BC014203 AW028411 AA046820 
    AI382308 AA927591 BE672956 AI087002 BI496630 AK093557 AI127730 BQ960938 

    GeneLoc Exon Structure


    Expression
    for FAM101B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM101B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM101B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FAM101B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM101B

    SOURCE GeneReport for Unigene clusters: Hs.345588 Hs.723693 Hs.741149
        SABiosciences Custom PCR Arrays for FAM101B
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM101B

    Orthologs
    for FAM101B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FAM101B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FAM101B1 family with sequence similarity 101, member B 74.37(n)
    68.4(a)    		   417623  XM_415867.3  XP_415867.3 
    lizard
    (Anolis carolinensis)    		 Reptilia FAM101B6
    		 --
    		 62(a)
    		 1 ↔ 1
    		 GL343543.1(541332-542589)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX762421.12   -- 74.34(n)    BX762421.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fam101b1 family with sequence similarity 101, member B 59.5(n)
    53.23(a)    		   100286814  XM_002664625.1  XP_002664671.1 


    ENSEMBL Gene Tree for FAM101B (if available)
    TreeFam Gene Tree for FAM101B (if available) 

    Paralogs
    for FAM101B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM101B gene
    FAM101A2  
    1 SIMAP similar gene for FAM101B using alignment to 3 protein entries:     F101B_HUMAN (see all proteins):
    FAM101A

    FAM101B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM101B
    PGOHUM00000245810


    Genomic Variants
    for FAM101B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM101B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM101B

    Disorders / Diseases
    for FAM101B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for FAM101B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM101B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM101B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for FAM101B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM101B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 359845 HGNC: 28705 AceView: MGC45871 Ensembl:ENSG00000183688 euGenes: HUgn359845
    ECgene: FAM101B H-InvDB: FAM101B

    Other Databases showing FAM101B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM101B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM101B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM101B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM101B gene:
    Search GeneIP for patents involving FAM101B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM101B gene

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    Advanced Cell Diagnostics
    About This Section

     
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