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FAM101A Gene

protein-coding   GIFtS: 37
GCID: GC12P124463

Family With Sequence Similarity 101, Member A

  Search for FAM101A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 101, Member A1 2
Protein FAM101A2

External Ids:    HGNC: 270511   Entrez Gene: 1443472   Ensembl: ENSG000001788827   UniProtKB: Q6ZTI63   

Export aliases for FAM101A gene to outside databases

Previous GC identifers: GC12P123299 GC12P124775 GC12P121736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM101A Gene:
FAM101A (family with sequence similarity 101, member A) is a protein-coding gene. An important paralog of this gene is FAM101B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM101A gene promoter:
         NF-YA   HNF-4alpha2   NF-YB   PPAR-gamma1   CBF-A   CBF-B   CP1A   PPAR-gamma2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM101A promoter sequence
   Search Chromatin IP Primers for FAM101A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM101A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

FAM101A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM101A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124463:  view genomic region     (about GC identifiers)

Start:
124,457,788 bp from pter      End:
124,800,570 bp from pter
Size:
342,783 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F101A_HUMAN, Q6ZTI6 (See protein sequence)
Recommended Name: Protein FAM101A  
Size: 216 amino acids; 23610 Da
Secondary accessions: A5D8T5
Alternative splicing: 2 isoforms:  Q6ZTI6-1   Q6ZTI6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM101A: NX_Q6ZTI6

Explore proteomics data for FAM101A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM101A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_859060.3  
    ENSEMBL proteins: 
     ENSP00000476717   ENSP00000315626   ENSP00000444080   ENSP00000345898   ENSP00000374377  

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    Cloud-Clone Corp. ELISAs for FAM101A
    Cloud-Clone Corp. CLIAs for FAM101A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028215 FAM101

    Graphical View of Domain Structure for InterPro Entry Q6ZTI6

    ProtoNet protein and cluster: Q6ZTI6

    UniProtKB/Swiss-Prot: F101A_HUMAN, Q6ZTI6
    Similarity: Belongs to the FAM101 family


    FAM101A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM101A
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    SwitchGear 3'UTR luciferase reporter plasmidFAM101A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM101A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM101A
    Interactions:

        Search GeneGlobe Interaction Network for FAM101A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM101A (Q6ZTI63 ENSP000003156264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDFT1P372683, ENSP000002205844I2D: score=2 STRING: ENSP00000220584
    FBXW7Q969H03I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM101A (F101A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM101A gene: 
    NM_181709.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540762 ENST00000545615 ENST00000324038(uc001ugd.2) ENST00000546355(uc021rfy.1 uc001uge.2)
    ENST00000338359 ENST00000389727
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate FAM101A:
    hsa-miR-185 hsa-miR-4306 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM101A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM101A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM101A
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM101A
      QuantiFast Probe-based Assays in human, mouse, rat FAM101A

    Selected AceView cDNA sequences (see all 81):

    BM856800 AW264333 BU623432 AA454605 BM727604 BX113682 BQ182211 CR602224 
    BG117133 AK126577 AA234190 BU616428 NM_181709 BM681043 BM791031 AI082503 
    AI352145 AI122942 BG252074 BM795457 BM857020 BM676132 BM669699 BG222925 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM101A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAGACAA
    FAM101A Expression
    About this image

    FAM101A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM101A Protein Expression
        Custom PCR Arrays for FAM101A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM101A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM101A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM101A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam101a1 family with sequence similarity 101, member A 80.74(n)
    75.56(a)
      73121  NM_028443.2  NP_082719.1 
    chicken
    (Gallus gallus)
    Aves FAM101A6
    family with sequence similarity 101, member A
    42(a)
    1 ↔ 1
    15(4734252-4745661)
    lizard
    (Anolis carolinensis)
    Reptilia FAM101A6
    family with sequence similarity 101, member A
    40(a)
    1 ↔ 1
    LGb(1595171-1602861)
    zebrafish
    (Danio rerio)
    Actinopterygii fam101a6
    family with sequence similarity 101, member A
    32(a)
    1 ↔ 1
    8(45381426-45404021) ENSDARG00000023484


    ENSEMBL Gene Tree for FAM101A (if available)
    TreeFam Gene Tree for FAM101A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM101A gene
    ZNF664-FAM101A  FAM101B2  
    1 SIMAP similar gene for FAM101A using alignment to 2 protein entries:     F101A_HUMAN (see all proteins):
    FAM101B

    FAM101A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FAM101A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669580CNV Deletion23128226
    esv2746520CNV Deletion23290073
    esv2746521CNV Deletion23290073
    esv1202818CNV Insertion17803354
    dgv1499n71CNV Loss21882294
    nsv470322CNV Loss18288195
    nsv53622CNV Loss16902084
    nsv899581CNV Loss21882294
    nsv818930CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FAM101A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM101A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM101A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. (PubMed id 23490283)1 Kim J.C....Kim Y.S. (Int. J. Radiat. Oncol. Biol. Phys. 2013)
    5. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144347 HGNC: 27051 AceView: LOC144347 Ensembl:ENSG00000178882 euGenes: HUgn144347
    ECgene: FAM101A H-InvDB: FAM101A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM101A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM101A gene:
    Search GeneIP for patents involving FAM101A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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