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Aliases for FAM101A Gene

Aliases for FAM101A Gene

  • Family With Sequence Similarity 101, Member A 2 3
  • Regulator Of Filamin Protein A 3 4
  • RefilinA 3 4
  • Filamin-Interacting Protein FAM101A 3
  • Protein FAM101A 3
  • CFM2 3

External Ids for FAM101A Gene

Summaries for FAM101A Gene

GeneCards Summary for FAM101A Gene

FAM101A (Family With Sequence Similarity 101, Member A) is a Protein Coding gene. An important paralog of this gene is FAM101B.

UniProtKB/Swiss-Prot for FAM101A Gene

  • Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM101A Gene

Genomics for FAM101A Gene

Genomic Location for FAM101A Gene

Start:
123,973,215 bp from pter
End:
124,316,024 bp from pter
Size:
342,810 bases
Orientation:
Plus strand

Genomic View for FAM101A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM101A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM101A Gene

Regulatory Elements for FAM101A Gene

Proteins for FAM101A Gene

  • Protein details for FAM101A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTI6-F101A_HUMAN
    Recommended name:
    Filamin-interacting protein FAM101A
    Protein Accession:
    Q6ZTI6
    Secondary Accessions:
    • A5D8T5

    Protein attributes for FAM101A Gene

    Size:
    216 amino acids
    Molecular mass:
    23610 Da
    Quaternary structure:
    • Interacts with FLNA and FLNB.

    Alternative splice isoforms for FAM101A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM101A Gene

Proteomics data for FAM101A Gene at MOPED

Post-translational modifications for FAM101A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM101A Gene

No data available for DME Specific Peptides for FAM101A Gene

Domains for FAM101A Gene

Protein Domains for FAM101A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F101A_HUMAN
Family:
  • Belongs to the FAM101 family.:
    • Q6ZTI6
genes like me logo Genes that share domains with FAM101A: view

No data available for Gene Families for FAM101A Gene

Function for FAM101A Gene

Molecular function for FAM101A Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells.

Gene Ontology (GO) - Molecular Function for FAM101A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM101A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM101A Gene

Localization for FAM101A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM101A Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with FLNA along actin bundle-like structures. {ECO:0000250 UniProtKB:Q7TS73}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM101A Gene COMPARTMENTS Subcellular localization image for FAM101A gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM101A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM101A: view

Pathways for FAM101A Gene

SuperPathways for FAM101A Gene

No Data Available

Interacting Proteins for FAM101A Gene

Selected Interacting proteins: Q6ZTI6-F101A_HUMAN for FAM101A Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for FAM101A Gene

None

No data available for Pathways by source for FAM101A Gene

Transcripts for FAM101A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FAM101A Gene

No ASD Table

Relevant External Links for FAM101A Gene

GeneLoc Exon Structure for
FAM101A
ECgene alternative splicing isoforms for
FAM101A

Expression for FAM101A Gene

mRNA expression in normal human tissues for FAM101A Gene

mRNA differential expression in normal tissues according to GTEx for FAM101A Gene

This gene is overexpressed in Stomach (18.1) and Colon - Transverse (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM101A Gene

genes like me logo Genes that share expressions with FAM101A: view

Orthologs for FAM101A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM101A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM101A 36
  • 97.78 (n)
  • 97.78 (a)
FAM101A 37
  • 61 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM101A 36
  • 88.64 (n)
  • 88.15 (a)
FAM101A 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM101A 36
  • 88.47 (n)
  • 86.47 (a)
FAM101A 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam101a 36
  • 80.74 (n)
  • 75.56 (a)
Fam101a 37
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM101A 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM101A 37
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam101a 36
  • 78.52 (n)
  • 77.78 (a)
chicken
(Gallus gallus)
Aves FAM101A 37
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM101A 37
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam101a 37
  • 32 (a)
OneToOne
Species with no ortholog for FAM101A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM101A Gene

ENSEMBL:
Gene Tree for FAM101A (if available)
TreeFam:
Gene Tree for FAM101A (if available)

Paralogs for FAM101A Gene

Paralogs for FAM101A Gene

Selected SIMAP similar genes for FAM101A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM101A: view

Variants for FAM101A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM101A Gene

Variant ID Type Subtype PubMed ID
nsv818930 CNV Gain 17921354
nsv899581 CNV Loss 21882294
dgv1499n71 CNV Loss 21882294
esv1202818 CNV Insertion 17803354
esv2746520 CNV Deletion 23290073
esv2746521 CNV Deletion 23290073
esv2669580 CNV Deletion 23128226
nsv53622 CNV Loss 16902084
nsv470322 CNV Loss 18288195

Relevant External Links for FAM101A Gene

HapMap Linkage Disequilibrium report
FAM101A

No data available for Sequence variations from dbSNP and Humsavar for FAM101A Gene

Disorders for FAM101A Gene

No disorders were found for FAM101A Gene.

No data available for UniProtKB/Swiss-Prot for FAM101A Gene

Publications for FAM101A Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. (PMID: 23490283) Kim J.C. … Kim Y.S. (Int. J. Radiat. Oncol. Biol. Phys. 2013) 3

Products for FAM101A Gene

Sources for FAM101A Gene

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