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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM101A Gene

protein-coding   GIFtS: 36
GCID: GC12P124775

family with sequence similarity 101, member A
  Search for FAM101A
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM101A    

Aliases
for FAM101A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 101, Member A1 2
FLJ446141
Protein FAM101A2

External Ids:    HGNC: 270511   Entrez Gene: 1443472   Ensembl: ENSG000001788827   UniProtKB: Q6ZTI63   

Export aliases for FAM101A gene to outside databases

Previous GC identifers: GC12P123299 GC12P121736


Summaries
for FAM101A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM101A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM101A gene promoter:
         NF-YA   HNF-4alpha2   NF-YB   PPAR-gamma1   CBF-A   CBF-B   CP1A   PPAR-gamma2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAM101A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM101A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM101A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

FAM101A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM101A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124775:  view genomic region     (about GC identifiers)

Start:
 124,773,710 bp from pter      End:
 124,800,570 bp from pter
Size:
 26,861 bases      Orientation:
 plus strand

Proteins
for FAM101A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F101A_HUMAN, Q6ZTI6 (See protein sequence)
Recommended Name: Protein FAM101A  
Size: 216 amino acids; 23610 Da
Secondary accessions: A5D8T5
Alternative splicing: 2 isoforms:  Q6ZTI6-1   Q6ZTI6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM101A: NX_Q6ZTI6

FAM101A Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_859060.3  
ENSEMBL proteins: 
 ENSP00000315626   ENSP00000444080   ENSP00000345898   ENSP00000374377  

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Uscn Proteins for FAM101A


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Uscn ELISAs and CLIAs for FAM101A

Protein Domains /
Families
for FAM101A gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6ZTI6

UniProtKB/Swiss-Prot: F101A_HUMAN, Q6ZTI6
Similarity: Belongs to the FAM101 family


Function
for FAM101A gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM101A
3 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM101A:
hsa-miR-185 hsa-miR-4306 hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmid: FAM101A 3' UTR sequence
Inhib. RNA
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OriGene shRNA RFP: FAM101A
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Clone
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In Situ Assay
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Pathways & Interactions
for FAM101A gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM101A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for FAM101A (Q6ZTI63 ENSP000003156264) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
FDFT1P372683, ENSP000002205844I2D: score=2 STRING: ENSP00000220584
FBXW7Q969H03I2D: score=2 
About this table

Drugs & Compounds
for FAM101A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM101A
Search CenterWatch for drugs/clinical trials and news about FAM101A / F101A 

Transcripts
for FAM101A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for FAM101A gene: 
NM_181709.4  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000324038(uc001ugd.2) ENST00000546355(uc021rfy.1 uc001uge.2)
ENST00000338359 ENST00000389727

miRNA
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3 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM101A:
hsa-miR-185 hsa-miR-4306 hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmid: FAM101A 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM101A
OriGene shRNA RFP: FAM101A
OriGene siRNA: FAM101A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM101A
Clone
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Primer
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Browse OriGene validated miRNA SYBR primer pairs
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM101A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM101A

24/81 AceView cDNA sequences (see all 81):

CR602224 AA234190 AA454605 BU616428 AK126577 BU623432 BM727604 NM_181709 
BX113682 BQ182211 BM856800 AW264333 BG117133 BC042102 AI082503 AA378896 
BC026875 BM792694 BM791031 CB129126 BM051178 BM857020 AW293131 F13538 

GeneLoc Exon Structure


Expression
for FAM101A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM101A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCAGACAA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

FAM101A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Posterior foregut-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See FAM101A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM101A
    SABiosciences Custom PCR Arrays for FAM101A
Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM101A
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM101A

Orthologs
for FAM101A gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for FAM101A gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves FAM101A1 family with sequence similarity 101, member A 70.37(n)
65.93(a)		   771797  XM_001235027.2  XP_001235028.2 
lizard
(Anolis carolinensis)		 Reptilia FAM101A6
 --
 40(a)
 1 ↔ 1
 LGb(1595171-1602861)
zebrafish
(Danio rerio)		 Actinopterygii fam101a1 family with sequence similarity 101, member A 63.05(n)
54.26(a)		   368489  NM_001007031.2  NP_001007032.1 


ENSEMBL Gene Tree for FAM101A (if available)
TreeFam Gene Tree for FAM101A (if available) 

Paralogs
for FAM101A gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM101A gene
ZNF664-FAM101A  FAM101B2  
1 SIMAP similar gene for FAM101A using alignment to 1 protein entry:     F101A_HUMAN:
FAM101B

FAM101A for paralogs           About GeneDecksing



Genomic Variants
for FAM101A gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/629 NCBI SNPs in FAM101A are shown (see all 629)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 12 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs611594591,2
C,--124771787(+) GGTGTG/ACCACA 2 -- int1 us2k12Minor allele frequency- A:0.06WA 120
rs107730781,2
C,F,A,H,--124771833(+) TCGCCG/AAGTGA 2 -- us2k1 int19Minor allele frequency- A:0.48NA WA EA 376
rs768855471,2
F,--124771861(+) CAGTGC/TTCACA 2 -- us2k1 int12Minor allele frequency- T:0.06WA NA 238
rs773243551,2
--124771863(+) GTGCTC/AACACT 2 -- us2k1 int13Minor allele frequency- A:0.07CSA WA NA 239
rs760361551,2
F,--124771884(+) TGTGCA/GCGGGC 2 -- us2k1 int11Minor allele frequency- G:0.07WA 118
rs1441100041,2
--124771889(+) ACGGGC/TGCCAT 2 -- us2k1 int10--------
rs1853274811,2
--124771974(+) GAGCAA/GGAGAA 2 -- int1 us2k10--------
rs1473481631,2
--124772001(+) AGCTGA/GAAAAC 2 -- us2k1 int10--------
rs745818191,2
C,F,--124772007(+) AAAACG/AATAAA 2 -- us2k1 int11Minor allele frequency- A:0.04WA 118
rs1138280351,2
--124772087(+) CACCCG/ACTACT 2 -- us2k1 int12Minor allele frequency- A:0.06CSA WA 120

HapMap Linkage Disequilibrium report for FAM101A (124773710 - 124800570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FAM101A
     2 CNVs: 29926 9699
     1 Indel: 11647

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for FAM101A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for FAM101A gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM101A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM101A)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

External Searches for FAM101A gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing FAM101A gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 144347 HGNC: 27051 AceView: LOC144347 Ensembl:ENSG00000178882 euGenes: HUgn144347
ECgene: FAM101A H-InvDB: FAM101A

Other Databases showing FAM101A gene

(According to HUGE)
About This Section
   --

Specialized Databases showing FAM101A gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM101A Pharmacogenomics, SNPs, Pathways

Intellectual Property
for FAM101A gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM101A gene:
Search GeneIP for patents involving FAM101A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for FAM101A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
About This Section

 
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 Regulatory tfbs in FAM101A promoter
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM101A
 SwitchGear 3'UTR luciferase reporter plasmids for FAM101A
 SwitchGear Promoter luciferase reporter plasmids for FAM101A
 Search ThermoFisher Antibodies for FAM101A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM101A
       
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VWF
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von Willebrand factor
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