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FAM100B Gene

protein-coding   GIFtS: 37

GC17P071774
family with sequence similarity 100, member B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for FAM100B

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
MGC29814 1, 2
MGC71792 2
Descriptions
family with sequence similarity 100, member B 2
hypothetical protein LOC283991 2
External Ids
HGNC: 284381
Entrez Gene: 2839912
UniProtKB: Q8IYN63
Ensembl: ENSG000001852627
Search outside databases for aliases for FAM100B gene

Summaries
for FAM100B

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for FAM100B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAM100B gene  

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

FAM100B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P071774:     (about GC identifiers)

Start:
 71,773,043 bp from pter
End:
 71,778,970 bp from pter
Size:
 5,928 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  

Proteins
for FAM100B

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: F100B_HUMAN, Q8IYN6 (See protein sequence)
Recommended Name: Protein FAM100B  
Size: 164 amino acids; 17877 Da
PDB structures from and Proteopedia :
2DZL (3D)    

REFSEQ proteins: NP_872371.1  

ENSEMBL proteins: 
ENSP00000331298 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for FAM100B: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for FAM100B
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for FAM100B

Assays for FAM100B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for FAM100B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8IYN6

UniProtKB/Swiss-Prot: F100B_HUMAN, Q8IYN6
Similarity: Belongs to the FAM100 family

Gene Function
for FAM100B

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (FAM100B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182565

              Applied Biosystems Silencer® siRNAs for FAM100B

              Sigma-Aldrich siRNA for FAM100B  
                     Sigma-Aldrich shRNA for FAM100B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182565
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182565
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_182565 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_182565

Pathways & Interactions
for FAM100B

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for FAM100B (ENSP000003312983) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PTPLBENSP000003731533STRING (score=.706)
NDUFAF4ENSP000003582723STRING (score=.7)
About this table

Drugs & Compounds
for FAM100B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM100B

Transcripts
for FAM100B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (FAM100B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182565

              Sigma-Aldrich siRNA for FAM100B  
                     Sigma-Aldrich shRNA for FAM100B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_182565  

REFSEQ mRNAs for FAM100B gene: 

NM_182565.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_182565  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182565
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182565
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_182565 

Additional cDNA sequence: 

BC035511.2 BC060859.1 CR590966.1 CR596963.1 CR599986.1 CR613339.1 CR616618.1 

6 DOTS entries:

DT.97801867  DT.97822107  DT.100780492  DT.120989838  DT.95171573  DT.100780494 

24/176 AceView cDNA sequences (see all 176 ):

BE467165 AW518876 BF343516 BF344266 AI337032 BE502753 AI672588 BQ024054 
AW016185 C01495 AI198030 BQ102297 BQ668463 CR599986 AA689580 BM691466 
BM014874 AI887573 CR613339 BE349197 AI831873 CA432334 AI743889 BU738572 

highest scoring ESTs for FAM100B:

AI198956 AI968669 AW016185 AA026391 AA037857 AA062983 AA082302 AA129981 AA278503 AA279056 

Unigene Cluster for FAM100B:

Family with sequence similarity 100, member B
Hs.719201  [show with all ESTs]
Unigene Representative Sequence: NM_182565


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000327490  

Expression
for FAM100B

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM100B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FAM100B

1 / 2 / 3

8 probe-sets matching FAM100B gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

57046_at2, 3 U95-B 1 1.00 1.00 0.93 0.95 AI198956 1.00 1.00 1.00 1

88128_f_at2, 3 U95-E 1 1.00 1.00 0.98 1.05 AI968669 1.00 1.00 1.00 1
89990_f_at2, 3 U95-D 1 1.00 1.00 0.93 1.00 AW016185 1.00 1.00 1.00 1

78346_at2, 3 U95-E 2 1.00 0.97 0.96 1.00 AA131196 0.40 1.00 0.76 1

224785_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

224783_at2, 3 U133-B 1 1.00 1.00 -- -- AA831661 0.80 1.00 0.91 1

224785_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

224783_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  FAM100B for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719201

Orthologs
for FAM100B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for FAM100B gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 LOC7392341   -- similar to Family with sequence similarity 100, member more 99.59(n)
100(a)		 739234  XM_001151089.1  XP_001151089.1 
cow
(Bos taurus)		 LOC6186171   -- similar to Family with sequence similarity 100, member more 93.7(n)
95.12(a)		 618617  XM_870950.2  XP_876043.2 
rat
(Rattus norvegicus)		 Fam100b1   -- family with sequence similarity 100, member B 91.82(n)
91.41(a)		 287840  XM_213532.3  XP_213532.2 
mouse
(Mus musculus)		 Fam100b1, 5 115
 family with sequence similarity 100, member B1, 5 90.59(n)1
90.8(a)1		 3193701  NM_176902.31  NP_795876.11 
 AI8461185  AK0037065  (see all 18)
chicken
(Gallus gallus)		 FAM100B1   -- family with sequence similarity 100, member B 83.33(n)
86.54(a)		 770332  XM_001233668.1  XP_001233669.1 
About this table        Species with no ortholog for FAM100B

ENSEMBL Gene Tree for FAM100B

Paralogs
for FAM100B

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FAM100B gene
FAM100A2  

SNPs/Variants
for FAM100B

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/49 NCBI SNPs in FAM100B are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 34)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs89011,2
A,C,F,H71778605(-) TGCCCG/AGTGAC 1 -- ut31 ese36Minor allele frequency- A:0.49MN EU EA WA 784
rs3476731,2
A,C71779344(-) TGAGGA/GGAGGA 1 -- ng310--------
rs26786721,2
C,H71772353(+) TCTGGG/AAGCTG 1 -- ng515Minor allele frequency- A:0.01EU EA WA NA 1818
rs10451661,2
F71778878(+) AAAGTG/AGAGAG 1 -- ut311Minor allele frequency- A:0.07MN 184
rs7128331,2
A,F,H71777917(+) CCCGAT/CGCGCT 1 D/D syn15Minor allele frequency- C:0.08MN EU EA WA 600
rs47892641,2
A,C,F,H71774643(+) ACCTTG/TTTAGC 1 -- int110Minor allele frequency- T:0.49EU EA WA NA 1020
--
rs1808831,2
A,C71775204(-) cctttC/Ttcaaa 1 -- int10--------
rs96746421,2
A,C71775899(+) CCGAGA/GGGGCA 1 -- int10--------
--
rs96745371,2
A,C71775649(+) ATTTTA/GGACAA 1 -- int10--------
rs80722021,2
F,H71774021(+) CCAGGG/TAGGGC 1 -- int14Minor allele frequency- T:0.16EU EA WA 416
About this table

HapMap Linkage Disequilibrium images for FAM100B (up to first 250kb)

Disorders & Mutations
for FAM100B

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for FAM100B

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for FAM100B

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

2 PubMed articles for FAM100B gene:

Search for FAM100B

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing FAM100B

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 283991 HGNC: 28438 AceView: MGC29814 Ensembl:ENSG00000185262 euGenes: HUgn283991
ECgene: FAM100B H-InvDB: FAM100B

Other Databases showing FAM100B

(According to HUGE)
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   --

Specialized Databases showing FAM100B

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for FAM100B

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for FAM100B

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FAM100B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAM100B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for FAM100B Antibodies for FAM100B
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for FAM100B Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search Novus for antibodies for FAM100B

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