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FAM100A Gene

protein-coding GIFtS: 40

GC16M004599

family with sequence similarity 100, member A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ31223 ^²
FLJ32185 ^²
PP11303 ^²

Descriptions
family with sequence similarity 100, member A ^²
hypothetical protein LOC124402 ^²

External Ids
HGNC: 29576¹
Entrez Gene: 124402²
UniProtKB: Q8TB05³
Ensembl: ENSG00000153443⁷

Search outside databases for aliases for FAM100A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FAM100A gene

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

FAM100A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M004599: (about GC identifiers)

Start:	4,598,885 bp from pter
End:	4,604,928 bp from pter
Size:	6,044 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: F100A_HUMAN, Q8TB05 (See protein sequence)

Recommended Name: Protein FAM100A

Size: 177 amino acids; 18954 Da

Secondary accessions: Q71MF6

Alternative splicing: 2 isoforms: Q8TB05-1 Q8TB05-2

REFSEQ proteins: NP_660296.1

ENSEMBL proteins:

ENSP00000283474

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (FAM100A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for FAM100A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FAM100A

Assays for FAM100A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8TB05

UniProtKB/Swiss-Prot: F100A_HUMAN, Q8TB05

Similarity: Belongs to the FAM100 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM100A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_145253

Applied Biosystems Silencer® siRNAs for FAM100A

Sigma-Aldrich siRNA for FAM100A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FAM100A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_145253
Myc/DDK tagged cDNA clone in CMV expression vector: NM_145253
untagged cDNA clones in CMV expression vector (see all 3): AK055785

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_145253

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FAM100A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FAM100A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_145253

Sigma-Aldrich siRNA for FAM100A

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_145253

REFSEQ mRNAs for FAM100A gene:

NM_145253.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_145253

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145253
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145253
                                 untagged cDNA clones in CMV expression vector (see all 3): AK055785

Additional cDNA sequence:

AF370434.1 AK055785.1 AK056747.1 AK123636.1 BC008681.1 BC012018.1 BC025327.1 BC040160.1

BC062534.1 CR608937.1

8 DOTS entries:

DT.91979584 DT.91702998 DT.95320502 DT.95269094 DT.100693593 DT.102824868 DT.102824870 DT.75154845

24/121 AceView cDNA sequences (see all 121 ):

BQ669438 F37812 BE856719 AW015675 AA701309 BM785544 BM673763 AI801861

CR608937 AI926801 AA679059 BM712914 BQ712647 BM555223 BM765099 BM558675

CA418336 AI961676 AI810457 AF447881 AA932365 AA984794 BC062534 BC012018

highest scoring ESTs for FAM100A:

AI829660 AW630076 BC008681 BC012018 BC025327 BC040160 BC062534 BE383969 BE812409 BF127524

Unigene Cluster for FAM100A:

Family with sequence similarity 100, member A

Hs.513313 [show with all ESTs]

Unigene Representative Sequence: AK123636

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAM100A (see all 6 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d
SP1:			-		-		-		-		-
SP2:							-		-		-
SP3:							-		-
SP4:							-		-		-						-
SP5:											-

About this scheme

ECgene alternative splicing isoforms for FAM100A

1 Ensembl transcript including schematic representation:

ENST00000283474

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FAM100A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FAM100A

¹ / ² / ³

5 probe-sets matching FAM100A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90351_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI829660	0.80	1.00	0.91	1
225874_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE382898	0.20	1.00	0.72	1
225874_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558976_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558975_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCCCCTGC

SOURCE GeneReport for Unigene cluster: Hs.513313

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FAM100A gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC610415¹	--	hypothetical protein LOC610415	88.08(n) 93.43(a)	610415 XM_847917.1 XP_853010.1
chimpanzee (Pan troglodytes)	LOC748235¹	--	similar to RIKEN cDNA 1500031H01 gene	99.81(n) 100(a)	748235 XM_001169127.1 XP_001169127.1
cow (Bos taurus)	MGC142811¹	--	hypothetical protein LOC618672	90.4(n) 94.92(a)	618672 NM_001076951.1 NP_001070419.1
rat (Rattus norvegicus)	Fam100a¹	--	family with sequence similarity 100, member A	92.57(n) 94.86(a)	302941 NM_001007668.1 NP_001007669.1
mouse (Mus musculus)	Fam100a^{1, 5}	16⁵	family with sequence similarity 100, member A^{1, 5}	90.67(n)¹ 93.14(a)¹	207740¹ XM_974374.1¹ XP_979468.1¹ AI840699⁵ AI842624⁵ (see all 9)

About this table Species with no ortholog for FAM100A

ENSEMBL Gene Tree for FAM100A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FAM100A gene

FAM100B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in FAM100A are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs841190^1,2	A,C,F,H	4605288(+)	`GGGTTA/GGGGGA`	1	--	ng3¹		4		EU EA WA	416
	rs2279408^1,2	A,C,F,H	4598585(+)	`GAGATA/GAAACC`	1	--	ng5¹		7		EA EU WA NA	2080
	rs841191^1,2	A,C,H	4606002(+)	`CGCCTA/GTAGCT`	1	--	ng3¹		3		EU EA	300
	rs1982784^1,2	A,C	4606538(+)	`CTGACA/GGCTAG`	1	--	ng3¹		0	--	--	--	--
--	rs10775352^1,2	A,C	4605439(+)	`TGTGTC/GCAGGC`	1	--	ng3¹		0	--	--	--	--
	rs860889^1,2	C	4604834(+)	`CCTCCG/TCCGCC`	1	--	ut5¹ ese³ trp³		0	--	--	--	--
	rs841182^1,2	C	4599303(+)	`GTCTCC/TGCCAG`	1	--	ut3¹		1		MN	184
--	rs7191007^1,2	A	4605704(+)	`GGCACC/TCGTGC`	1	--	ng3¹		0	--	--	--	--
	rs841184^1,2	A,C,F,H	4600343(+)	`ACCCAT/CGGAGC`	1	--	int¹		5		MN EU EA WA	600
	rs863500^1,2	C,F,H	4600248(+)	`TCCCCG/AGGGGC`	1	--	int¹		5		EA EU WA	1916

About this table

HapMap Linkage Disequilibrium images for FAM100A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for FAM100A gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 124402	HGNC: 29576	AceView: LOC124402	Ensembl:ENSG00000153443	euGenes: HUgn124402
ECgene: FAM100A	H-InvDB: FAM100A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FAM100A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FAM100A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FAM100A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FAM100A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FAM100A)
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for FAM100A

Search Tocris compounds for FAM100A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for FAM100A

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FAM100A Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for FAM100A

Summaries
for FAM100A

Genomic Location
for FAM100A

Proteins
for FAM100A

Protein Domains/
Families
for FAM100A

Gene Function
for FAM100A

Pathways & Interactions
for FAM100A

Drugs & Compounds
for FAM100A

Transcripts
for FAM100A

Expression
for FAM100A

Orthologs
for FAM100A

Paralogs
for FAM100A

SNPs/Variants
for FAM100A

Disorders & Mutations
for FAM100A

Medical News
for FAM100A

Publications
for FAM100A

Search for FAM100A

Genome Databases showing FAM100A

Other Databases showing FAM100A

Specialized Databases showing FAM100A

Licensable Technologies
for FAM100A

Services
for FAM100A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FAM100A Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor FAM100A

Summariesfor FAM100A

Genomic Locationfor FAM100A

Proteinsfor FAM100A

Protein Domains/Familiesfor FAM100A

Gene Functionfor FAM100A

Pathways & Interactionsfor FAM100A

Drugs & Compoundsfor FAM100A

Transcriptsfor FAM100A

Expression for FAM100A

Orthologsfor FAM100A

Paralogsfor FAM100A

SNPs/Variantsfor FAM100A

Disorders & Mutationsfor FAM100A

Medical Newsfor FAM100A

Publicationsfor FAM100A

Search for FAM100A

Genome Databases showing FAM100A

Other Databases showing FAM100A

Specialized Databases showing FAM100A

Licensable Technologiesfor FAM100A

Servicesfor FAM100A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FAM100A

Summaries
for FAM100A

Genomic Location
for FAM100A

Proteins
for FAM100A

Protein Domains/
Families
for FAM100A

Gene Function
for FAM100A

Pathways & Interactions
for FAM100A

Drugs & Compounds
for FAM100A

Transcripts
for FAM100A

Expression
for FAM100A

Orthologs
for FAM100A

Paralogs
for FAM100A

SNPs/Variants
for FAM100A

Disorders & Mutations
for FAM100A

Medical News
for FAM100A

Publications
for FAM100A

Licensable Technologies
for FAM100A

Services
for FAM100A