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FAIM3 Gene

protein-coding   GIFtS: 48
GCID: GC01M207076

Fas Apoptotic Inhibitory Molecule 3

  Search for FAIM3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fas Apoptotic Inhibitory Molecule 31 2     Fc Mu Receptor2
TOSO2 3 5     IgM Fc Receptor2
Regulator Of Fas-Induced Apoptosis Toso2 3     Immunoglobulin Mu Fc Receptor2
FCMR2 5     

External Ids:    HGNC: 143151   Entrez Gene: 92142   Ensembl: ENSG000001628947   OMIM: 6060155   UniProtKB: O606673   

Export aliases for FAIM3 gene to outside databases

Previous GC identifers: GC01M203467 GC01M205144 GC01M177774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAIM3 Gene:
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each
Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 (PubMed 19858324); Shima
et al., 2010 (PubMed 20042454)).(supplied by OMIM, Jul 2010)

GeneCards Summary for FAIM3 Gene:
FAIM3 (Fas apoptotic inhibitory molecule 3) is a protein-coding gene. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced
apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an
inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic
signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAIM3 gene promoter:
         ER-alpha   HNF-1   CUTL1   Nkx2-5   HNF-1A   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAIM3 promoter sequence
   Search Chromatin IP Primers for FAIM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAIM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

FAIM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAIM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M207076:  view genomic region     (about GC identifiers)

Start:
207,076,630 bp from pter      End:
207,096,592 bp from pter
Size:
19,963 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667 (See protein sequence)
Recommended Name: Fas apoptotic inhibitory molecule 3 precursor  
Size: 390 amino acids; 43146 Da
Miscellaneous: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth
Secondary accessions: A8K7J2 B7Z6Z0 D9MWM3
Alternative splicing: 3 isoforms:  O60667-1   O60667-2   O60667-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAIM3: NX_O60667

Explore proteomics data for FAIM3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAIM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135945.1  NP_001180267.1  NP_005440.1  

    ENSEMBL proteins: 
     ENSP00000356058   ENSP00000404136   ENSP00000436799   ENSP00000432936   ENSP00000437331  
     ENSP00000436316   ENSP00000403356  

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    Search eBioscience for ELISAs for FAIM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry O60667

    ProtoNet protein and cluster: O60667

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Domain: The Ig-like domain is required for the anti-apoptotic ability
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Find genes that share domains with FAIM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAIM3_HUMAN, O60667
    Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced
    apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an
    inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic
    signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation
    Induction: By T-cell activation

    Phenotypes:
         2 GenomeRNAi human phenotypes for FAIM3:

     Cell cycle / mitosis defect  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Faim3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with FAIM3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FAIM3: Faim3tm1.2Khl Faim3tm1Mak Faim3tm1Ohno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAIM3
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    hsa-miR-922 hsa-miR-593* hsa-miR-608 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFAIM3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAIM3_HUMAN, O60667: Isoform 1: Membrane; Single-pass membrane protein
    FAIM3_HUMAN, O60667: Isoform 3: Secreted. Note=Detected in the serum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAIM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAIM3
    Interactions:

        Search GeneGlobe Interaction Network for FAIM3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FAIM3 (O606673 ENSP000003560584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXD9P283563, ENSP000002494994I2D: score=1 STRING: ENSP00000249499
    ZNHIT3Q156493, ENSP000002254104I2D: score=1 STRING: ENSP00000225410
    ANKRD2Q9GZV13, ENSP000003061634I2D: score=1 STRING: ENSP00000306163
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0006968cellular defense response TAS9586636
    GO:0043066negative regulation of apoptotic process TAS9586636

    Find genes that share ontologies with FAIM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAIM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAIM3 gene (4 alternative transcripts): 
    NM_001142472.1  NM_001142473.1  NM_001193338.1  NM_005449.4  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367091(uc001hey.3 uc010prz.2 uc021pif.1 uc010psa.2)
    ENST00000474041 ENST00000442471 ENST00000528654 ENST00000463473 ENST00000525793
    ENST00000529560 ENST00000533312 ENST00000530505 ENST00000420007
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate FAIM3:
    hsa-miR-922 hsa-miR-593* hsa-miR-608 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFAIM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAIM3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAIM3
      QuantiTect SYBR Green Assays in human, mouse, rat FAIM3
      QuantiFast Probe-based Assays in human, mouse, rat FAIM3

    Selected AceView cDNA sequences (see all 154):

    AA832318 BE674835 AI365575 BP338035 CK904055 AI434224 AW242211 AI399732 
    AW768503 AI638155 BI966051 AA769441 AA769190 AI084226 BE046111 BF975138 
    BI966014 BG494616 AW001912 BP340505 AA743771 AI439553 AI521306 CB158779 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAIM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTAAGCAG
    FAIM3 Expression
    About this image


    FAIM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    FAIM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAIM3 Protein Expression

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak
    expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat,
    CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293
    and HeLa. Detected at high levels in chronic lymphocytic leukemia cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FAIM3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faim31 , 5 Fas apoptotic inhibitory molecule 31, 5 72.95(n)1
    60.72(a)1
      1 (56.89 cM)5
    691691  NM_026976.21  NP_081252.11 
     1308656695 


    ENSEMBL Gene Tree for FAIM3 (if available)
    TreeFam Gene Tree for FAIM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAIM3 gene
    FCAMR2  PIGR2  
    1 SIMAP similar gene for FAIM3 using alignment to 5 protein entries:     FAIM3_HUMAN (see all proteins):
    FLJ20555

    Find genes that share paralogs with FAIM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAIM3 (see all 412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30934401,2
    C,F,H--207078197(+) GGGGGC/AAGAGC 3 -- ut31 ese37Minor allele frequency- A:0.00NS EA 792
    rs2022059561,2
    --207078317(+) ACTCCC/TTGGCA 3 -- ut310--------
    rs562685281,2
    C,F--207078331(+) CAGTCC/TGAGCC 3 -- ut312Minor allele frequency- T:0.00NA EU 1325
    rs1428470061,2
    C,F--207078372(+) GGCAGG/TAACAT 5 T P mis1 ut312Minor allele frequency- T:0.00NA EU 5875
    rs1381088421,2
    C--207078409(+) TCCATC/GATGGC 5 I M mis1 ut311Minor allele frequency- G:0.00NA 4552
    rs2008374721,2
    C--207078414(+) CATGGC/TGGCAG 5 T A mis1 ut311Minor allele frequency- T:0.00EU 1323
    rs2010353331,2
    --207078415(+) ATGGCA/GGCAGG 5 A syn1 ut310--------
    rs2006902501,2
    --207078442(+) ACGTAA/TTCACA 5 E D mis1 ut310--------
    rs413040911,2
    C,F--207078467(+) ATGGGG/ACATGG 5 /A /V mis1 ut313Minor allele frequency- A:0.01NA EU 5993
    rs1879760791,2
    --207078649(+) GTAGCC/TCTGGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FAIM3 (207076630 - 207096592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAIM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468049CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAIM3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606015    OMIM disorders: --


    Find genes that share disorders with FAIM3           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: FAIM3 (1 document)

    Export disorders for FAIM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAIM3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with FAIM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (PubMed id 9586636)1, 2, 3 Hitoshi Y.... Nolan G.P. (Immunity 1998)
    2. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. (PubMed id 21908424)1, 2 Li F.J.... Kubagawa H. (Blood 2011)
    3. Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. (PubMed id 1563211)1, 3 Rainsford K.D....Hantsbarger G. (Clin. Pharmacol. Ther. 1992)
    4. Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. (PubMed id 22675200)1 Murakami Y....Coligan J.E. (J. Immunol. 2012)
    5. Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. (PubMed id 21264533)1 Hancer V.S....Aktan M. (Med. Oncol. 2012)
    6. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    7. TOSO is overexpressed and correlated with disease progression in Chinese patients with chronic lymphocytic leukemia. (PubMed id 21133733)1 Yi S....Qiu L. (amp 2011)
    8. [Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients]. (PubMed id 21756805)1 Yu Z....Qiu L.G. (Zhonghua Yi Xue Za Zhi 2011)
    9. Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. (PubMed id 21613257)1 Nguyen X.H....Lee K.H. (Blood 2011)
    10. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. (PubMed id 21908732)1 Vire B....Wiestner A. (J. Immunol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9214 HGNC: 14315 AceView: TOSO Ensembl:ENSG00000162894 euGenes: HUgn9214
    ECgene: FAIM3 H-InvDB: FAIM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAIM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAIM3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAIM3 gene:
    Search GeneIP for patents involving FAIM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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