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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAIM3 Gene

protein-coding   GIFtS: 51
GCID: GC01M207076

Fas Apoptotic Inhibitory Molecule 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fas Apoptotic Inhibitory Molecule 31 2     Fc Mu Receptor2
TOSO2 3 5     IgM Fc Receptor2
Regulator Of Fas-Induced Apoptosis Toso2 3     Immunoglobulin Mu Fc Receptor2
FCMR2 5     

External Ids:    HGNC: 143151   Entrez Gene: 92142   Ensembl: ENSG000001628947   OMIM: 6060155   UniProtKB: O606673   

Export aliases for FAIM3 gene to outside databases

Previous GC identifers: GC01M203467 GC01M205144 GC01M177774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAIM3 Gene:
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each
Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 (PubMed 19858324); Shima
et al., 2010 (PubMed 20042454)).(supplied by OMIM, Jul 2010)

GeneCards Summary for FAIM3 Gene: 
FAIM3 (Fas apoptotic inhibitory molecule 3) is a protein-coding gene. Diseases associated with FAIM3 include chronic lymphocytic leukemia, and intrahepatic cholangiocarcinoma. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced
apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an
inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic
signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAIM3 gene promoter:
         ER-alpha   HNF-1   CUTL1   Nkx2-5   HNF-1A   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAIM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAIM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAIM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

FAIM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAIM3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M207076:  view genomic region     (about GC identifiers)

Start:
207,076,630 bp from pter      End:
207,096,592 bp from pter
Size:
19,963 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667 (See protein sequence)
Recommended Name: Fas apoptotic inhibitory molecule 3 precursor  
Size: 390 amino acids; 43146 Da
Subcellular location: Isoform 1: Membrane; Single-pass membrane protein
Subcellular location: Isoform 3: Secreted. Note=Detected in the serum
Miscellaneous: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth
Secondary accessions: A8K7J2 B7Z6Z0 D9MWM3
Alternative splicing: 3 isoforms:  O60667-1   O60667-2   O60667-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAIM3: NX_O60667

Explore proteomics data for FAIM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60667

  • FAIM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAIM3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001135945.1  NP_001180267.1  NP_005440.1  

    ENSEMBL proteins: 
     ENSP00000356058   ENSP00000404136   ENSP00000436799   ENSP00000432936   ENSP00000437331  
     ENSP00000436316   ENSP00000403356  

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    OriGene Protein Over-expression Lysate for FAIM3
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    Sino Biological Recombinant Protein for FAIM3
    Sino Biological Cell Lysate for FAIM3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAIM3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral to membrane IEA--

    FAIM3 for ontologies           About GeneDecksing



    FAIM3 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for FAIM3 
    Cloud-Clone Corp. CLIAs for FAIM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry O60667

    ProtoNet protein and cluster: O60667

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Domain: The Ig-like domain is required for the anti-apoptotic ability
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    FAIM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAIM3_HUMAN, O60667
    Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced
    apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an
    inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic
    signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation
    Induction: By T-cell activation

    Phenotypes:
         2 GenomeRNAi human phenotypes for FAIM3:

     Cell cycle / mitosis defect  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Faim3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    FAIM3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FAIM3: Faim3tm1.2Khl Faim3tm1Mak Faim3tm1Ohno

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAIM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAIM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAIM3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAIM3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAIM3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FAIM3:
    hsa-miR-922 hsa-miR-593* hsa-miR-608 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFAIM3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Sirion Biotech Customized adenovirus for overexpression of FAIM3

    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAIM3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FAIM3 (O606673 ENSP000003560584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXD9P283563, ENSP000002494994I2D: score=1 STRING: ENSP00000249499
    ZNHIT3Q156493, ENSP000002254104I2D: score=1 STRING: ENSP00000225410
    ANKRD2Q9GZV13, ENSP000003061634I2D: score=1 STRING: ENSP00000306163
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006968cellular defense response TAS9586636
    GO:0043066negative regulation of apoptotic process TAS9586636

    FAIM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAIM3

    Search CenterWatch for drugs/clinical trials and news about FAIM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAIM3 gene (4 alternative transcripts): 
    NM_001142472.1  NM_001142473.1  NM_001193338.1  NM_005449.4  

    Unigene Cluster for FAIM3:

    Fas apoptotic inhibitory molecule 3
    Hs.744273  [show with all ESTs]
    Unigene Representative Sequence: NM_005449
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367091(uc001hey.3 uc010prz.2 uc021pif.1 uc010psa.2)
    ENST00000474041 ENST00000442471 ENST00000528654 ENST00000463473 ENST00000525793
    ENST00000529560 ENST00000533312 ENST00000530505 ENST00000420007
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAIM3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FAIM3:
    hsa-miR-922 hsa-miR-593* hsa-miR-608 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFAIM3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for FAIM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAIM3
    Clone
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    OriGene clones in human, mouse for FAIM3 (see all 23)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAIM3 (NM_005449)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM3
    Sirion Biotech Customized lentivirus for stable overexpression of FAIM3 
                         Customized lentivirus expression plasmids for stable overexpression of FAIM3 
    Primer
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    OriGene qPCR primer pairs and template standards for FAIM3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAIM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAIM3

    Additional mRNA sequence: 

    AF057557.1 AK292007.1 AK297053.1 AK301187.1 AK316336.1 BC006401.2 BT006797.1 GQ160900.1 
    GQ160901.1 HM480394.1 

    8 DOTS entries:

    DT.40114875  DT.86849036  DT.95141850  DT.121352753  DT.95121641  DT.101976578  DT.40125647  DT.91970856 

    24/154 AceView cDNA sequences (see all 154):

    AI434224 BI966187 BG055089 AA806272 AW242211 AI762709 AI521306 AW137293 
    AI440057 AA769441 AA281635 AW768503 BI966014 AW512632 BC006401 AI439553 
    BE045959 AW001912 AA991282 CK904055 AA744586 AW571597 BQ707299 CB158779 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAIM3 expression in normal human tissues (normalized intensities)      FAIM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTAAGCAG
    FAIM3 Expression
    About this image


    FAIM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Double Positive Thymocytes Thymus
             Peripheral blood Pan-T Cells   
     
     Melanocytes (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             Thymus   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   

    See FAIM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAIM3

    SOURCE GeneReport for Unigene cluster: Hs.744273

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak
    expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat,
    CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293
    and HeLa. Detected at high levels in chronic lymphocytic leukemia cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAIM3 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faim31 , 5 Fas apoptotic inhibitory molecule 31, 5 72.95(n)1
    60.72(a)1
      1 (56.89 cM)5
    691691  NM_026976.21  NP_081252.11 
     1308656695 
    zebrafish
    (Danio rerio)
    Actinopterygii FAIM36
    Fas apoptotic inhibitory molecule 3
    2(a)
    1 → many
    1(58265629-58267053)


    ENSEMBL Gene Tree for FAIM3 (if available)
    TreeFam Gene Tree for FAIM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAIM3 gene
    FCAMR2  PIGR2  
    1 SIMAP similar gene for FAIM3 using alignment to 5 protein entries:     FAIM3_HUMAN (see all proteins):
    FLJ20555

    FAIM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/412 SNPs in FAIM3 are shown (see all 412)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30934401,2
    C,F,H--207078197(+) GGGGGC/AAGAGC 3 -- ut31 ese37Minor allele frequency- A:0.00NS EA 792
    rs2022059561,2
    --207078317(+) ACTCCC/TTGGCA 3 -- ut310--------
    rs562685281,2
    C,F--207078331(+) CAGTCC/TGAGCC 3 -- ut312Minor allele frequency- T:0.00NA EU 1325
    rs1428470061,2
    C,F--207078372(+) GGCAGG/TAACAT 5 T P mis1 ut312Minor allele frequency- T:0.00NA EU 5875
    rs1381088421,2
    C--207078409(+) TCCATC/GATGGC 5 I M mis1 ut311Minor allele frequency- G:0.00NA 4552
    rs2008374721,2
    C--207078414(+) CATGGC/TGGCAG 5 T A mis1 ut311Minor allele frequency- T:0.00EU 1323
    rs2010353331,2
    --207078415(+) ATGGCA/GGCAGG 5 A syn1 ut310--------
    rs2006902501,2
    --207078442(+) ACGTAA/TTCACA 5 E D mis1 ut310--------
    rs413040911,2
    C,F--207078467(+) ATGGGG/ACATGG 5 /A /V mis1 ut313Minor allele frequency- A:0.01NA EU 5993
    rs1879760791,2
    --207078649(+) GTAGCC/TCTGGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for FAIM3 (207076630 - 207096592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAIM3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv468049CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAIM3
    DNA2.0 Custom Variant and Variant Library Synthesis for FAIM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606015    OMIM disorders: --

    6 diseases for FAIM3:    About MalaCards
    chronic lymphocytic leukemia    intrahepatic cholangiocarcinoma    cholangiocarcinoma    hepatitis b
    hepatitis    leukemia


    FAIM3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: FAIM3 (1 document)

    Export disorders for FAIM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAIM3 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with FAIM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (PubMed id 9586636)1, 2, 3 Hitoshi Y.... Nolan G.P. (1998)
    2. Enhanced levels of both the membrane-bound and solubl e forms of IgM Fc receptor (FcI1R) in patients with chronic lymphocytic leukemia . (PubMed id 21908424)1, 2 Li F.J....Kubagawa H. (2011)
    3. Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. (PubMed id 1563211)1, 3 Rainsford K.D....Hantsbarger G. (1992)
    4. Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. (PubMed id 22675200)1 Murakami Y....Coligan J.E. (2012)
    5. Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. (PubMed id 21264533)1 Hancer V.S....Aktan M. (2012)
    6. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    7. TOSO is overexpressed and correlated with disease pro gression in Chinese patients with chronic lymphocytic leukemia. (PubMed id 21133733)1 Yi S....Qiu L. (2011)
    8. [Expression and prognostic significance of TOSO in CD 19+ B cells from Chinese CLL patients]. (PubMed id 21756805)1 Yu Z....Qiu L.G. (2011)
    9. Toso regulates the balance between apoptotic and nona poptotic death receptor signaling by facilitating RIP1 ubiquitination. (PubMed id 21613257)1 Nguyen X.H....Lee K.H. (2011)
    10. TOSO, the Fcmicro receptor, is highly expressed on ch ronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. (PubMed id 21908732)1 Vire B....Wiestner A. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9214 HGNC: 14315 AceView: TOSO Ensembl:ENSG00000162894 euGenes: HUgn9214
    ECgene: FAIM3 H-InvDB: FAIM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for FAIM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAIM3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for FAIM3 gene:
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