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Aliases for FAIM3 Gene

Aliases for FAIM3 Gene

  • Fas Apoptotic Inhibitory Molecule 3 2 3
  • TOSO 3 4 6
  • Regulator Of Fas-Induced Apoptosis Toso 3 4
  • FCMR 3 6
  • Immunoglobulin Mu Fc Receptor 3
  • IgM Fc Receptor 3
  • Fc Mu Receptor 3

External Ids for FAIM3 Gene

Previous GeneCards Identifiers for FAIM3 Gene

  • GC01M203467
  • GC01M205144
  • GC01M207076
  • GC01M177774

Summaries for FAIM3 Gene

Entrez Gene Summary for FAIM3 Gene

  • Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

GeneCards Summary for FAIM3 Gene

FAIM3 (Fas Apoptotic Inhibitory Molecule 3) is a Protein Coding gene. An important paralog of this gene is FCAMR.

UniProtKB/Swiss-Prot for FAIM3 Gene

  • May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAIM3 Gene

Genomics for FAIM3 Gene

Regulatory Elements for FAIM3 Gene

Genomic Location for FAIM3 Gene

Start:
206,903,285 bp from pter
End:
206,923,247 bp from pter
Size:
19,963 bases
Orientation:
Minus strand

Genomic View for FAIM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM3 Gene

Proteins for FAIM3 Gene

  • Protein details for FAIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60667-FAIM3_HUMAN
    Recommended name:
    Fas apoptotic inhibitory molecule 3
    Protein Accession:
    O60667
    Secondary Accessions:
    • A8K7J2
    • B7Z6Z0
    • D9MWM3

    Protein attributes for FAIM3 Gene

    Size:
    390 amino acids
    Molecular mass:
    43146 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Toso is a Japanese liquor drunk on New Years day to celebrate long life and eternal youth

    Alternative splice isoforms for FAIM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAIM3 Gene

Proteomics data for FAIM3 Gene at MOPED

Post-translational modifications for FAIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAIM3 Gene

Domains for FAIM3 Gene

Gene Families for FAIM3 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for FAIM3 Gene

Graphical View of Domain Structure for InterPro Entry

O60667

UniProtKB/Swiss-Prot:

FAIM3_HUMAN :
  • O60667
Domain:
  • The Ig-like domain is required for the anti-apoptotic ability
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with FAIM3: view

Function for FAIM3 Gene

Molecular function for FAIM3 Gene

UniProtKB/Swiss-Prot Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
UniProtKB/Swiss-Prot Induction: By T-cell activation.
genes like me logo Genes that share phenotypes with FAIM3: view

Animal Models for FAIM3 Gene

MGI Knock Outs for FAIM3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for FAIM3 Gene

Localization for FAIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM3 Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 3: Secreted. Note=Detected in the serum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAIM3 Gene COMPARTMENTS Subcellular localization image for FAIM3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAIM3: view

Pathways for FAIM3 Gene

SuperPathways for FAIM3 Gene

No Data Available

Interacting Proteins for FAIM3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356058%0d%0a9606.ENSP00000249499%0d%0a9606.ENSP00000306163%0d%0a
Selected Interacting proteins: ENSP00000356058 O60667-FAIM3_HUMAN for FAIM3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 9586636
GO:0043066 negative regulation of apoptotic process TAS 9586636
genes like me logo Genes that share ontologies with FAIM3: view

No data available for Pathways by source for FAIM3 Gene

Transcripts for FAIM3 Gene

Unigene Clusters for FAIM3 Gene

Fas apoptotic inhibitory molecule 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAIM3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM3 Gene

No ASD Table

Relevant External Links for FAIM3 Gene

GeneLoc Exon Structure for
FAIM3
ECgene alternative splicing isoforms for
FAIM3

Expression for FAIM3 Gene

mRNA expression in normal human tissues for FAIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAIM3 Gene

This gene is overexpressed in Whole Blood (12.2), Spleen (11.3), and Small Intestine - Terminal Ileum (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAIM3 Gene

SOURCE GeneReport for Unigene cluster for FAIM3 Gene Hs.744273

mRNA Expression by UniProt/SwissProt for FAIM3 Gene

O60667-FAIM3_HUMAN
Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.
genes like me logo Genes that share expressions with FAIM3: view

In Situ Assay Products

Orthologs for FAIM3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAIM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAIM3 35
  • 99.4 (n)
  • 99.74 (a)
FAIM3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAIM3 35
  • 77.92 (n)
  • 67.01 (a)
FAIM3 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAIM3 35
  • 79.67 (n)
  • 67.96 (a)
FAIM3 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faim3 35
  • 72.95 (n)
  • 60.72 (a)
Faim3 16
Faim3 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAIM3 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAIM3 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faim3 35
  • 72.38 (n)
  • 59.22 (a)
Species with no ortholog for FAIM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAIM3 Gene

ENSEMBL:
Gene Tree for FAIM3 (if available)
TreeFam:
Gene Tree for FAIM3 (if available)

Paralogs for FAIM3 Gene

Paralogs for FAIM3 Gene

Selected SIMAP similar genes for FAIM3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAIM3: view

Variants for FAIM3 Gene

Sequence variations from dbSNP and Humsavar for FAIM3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs94872 -- 206,913,500(-) GGAGT(A/G)GAGGC intron-variant
rs167082 -- 206,914,090(-) GTATC(A/G)GGGGC intron-variant, synonymous-codon, reference, utr-variant-5-prime
rs182364 -- 206,923,523(+) CACAG(C/G)TGGGC upstream-variant-2KB
rs188334 -- 206,906,270(-) GGAAA(C/T)TTTAT intron-variant
rs189752 -- 206,906,437(-) CTTTT(C/T)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAIM3 Gene

Variant ID Type Subtype PubMed ID
nsv468049 CNV Loss 19166990

Relevant External Links for FAIM3 Gene

HapMap Linkage Disequilibrium report
FAIM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAIM3 Gene

Disorders for FAIM3 Gene

Relevant External Links for FAIM3

Human Genome Epidemiology (HuGE) Navigator
FAIM3
genes like me logo Genes that share disorders with FAIM3: view

No data available for UniProtKB/Swiss-Prot for FAIM3 Gene

Publications for FAIM3 Gene

  1. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (PMID: 9586636) Hitoshi Y. … Nolan G.P. (Immunity 1998) 2 3 4
  2. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia. (PMID: 21908424) Li F.J. … Kubagawa H. (Blood 2011) 3 4
  3. Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. (PMID: 1563211) Rainsford K.D. … Hantsbarger G. (Clin. Pharmacol. Ther. 1992) 2 3
  4. CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression. (PMID: 19703010) Richter G.H. … Burdach S. (Scand. J. Immunol. 2009) 23
  5. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. (PMID: 21908732) Vire B. … Wiestner A. (J. Immunol. 2011) 3

Products for FAIM3 Gene

Sources for FAIM3 Gene

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