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FAIM3 Gene

protein-coding   GIFtS: 49

GC01M205144
Fas apoptotic inhibitory molecule 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for FAIM3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000034619 2
TOSO 1, 2, 3
Descriptions
Fas apoptotic inhibitory molecule 3 2
Regulator of Fas-induced apoptosis Toso 3
regulator of Fas-induced apoptosis 2
External Ids
HGNC: 143151
Entrez Gene: 92142
UniProtKB: O606673
Ensembl: ENSG000001628947
Search outside databases for aliases for FAIM3 gene

Previous GC identifer: GC01M203467

Summaries
for FAIM3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and
FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and
BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS
stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis
by preventing CASP8 processing through CFLAR up-regulation

Genomic Location
for FAIM3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAIM3 gene  

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

FAIM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205144:     (about GC identifiers)

Start:
 205,144,354 bp from pter
End:
 205,161,966 bp from pter
Size:
 17,613 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.9  NT_021877.18  

Proteins
for FAIM3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667 (See protein sequence)
Recommended Name: Fas apoptotic inhibitory molecule 3 precursor  
Size: 390 amino acids; 43146 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Miscellaneous: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and
eternal youth

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001135944.1  NP_001135945.1  NP_005440.1  


    ENSEMBL proteins: 
    ENSP00000356058 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FAIM3)
    Human Recombinant Proteins from Abnova (FAIM3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0005886 plasma membrane IDA18029348
    GO:0005925 focal adhesion IDA18029348
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for FAIM3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FAIM3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (FAIM3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FAIM3)
    Novus Biologicals Antibodies for FAIM3

    Assays for FAIM3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for FAIM3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub
     IPR013151 Ig


       GeneDecks  FAIM3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O60667

    ProtoNet protein and cluster: O60667

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Domain: The Ig-like domain is required for the anti-apoptotic ability
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

    Gene Function
    for FAIM3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (FAIM3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FAIM3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005449

                  Applied Biosystems Silencer® siRNAs for FAIM3

                  Sigma-Aldrich siRNA for FAIM3  
                         Sigma-Aldrich shRNA for FAIM3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAIM3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001142472
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001142472
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001142472 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005449

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and
    FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and
    BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS
    stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis
    by preventing CASP8 processing through CFLAR up-regulation
    Induction: By T-cell activation

    Pathways & Interactions
    for FAIM3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5 Interacting proteins for FAIM3 (ENSP000003560583) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8ENSP000003512733STRING (score=.971)
    FADDENSP000003018383STRING (score=.931)
    FASLGENSP000003566943STRING (score=.927)
    FASENSP000003609423STRING (score=.899)
    --ENSP000003608523STRING (score=.899)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006916 anti-apoptosis TAS9586636
    GO:0006955 immune response IEA--
    GO:0006968 cellular defense response TAS9586636
    About this table

    Drugs & Compounds
    for FAIM3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAIM3

    Transcripts
    for FAIM3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (FAIM3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FAIM3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_005449

                  Sigma-Aldrich siRNA for FAIM3  
                         Sigma-Aldrich shRNA for FAIM3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001142472  NM_001142473  NM_005449  

    REFSEQ mRNAs for FAIM3 gene (3 alternative transcripts): 

    NM_001142472.1   NM_001142473.1   NM_005449.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001142472  NM_001142473  NM_005449  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001142472
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001142472
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001142472 

    Additional cDNA sequence: 

    AF057557.1 AK292007.1 AK297053.1 AK301187.1 AK316336.1 BC006401.2 BT006797.1 CR625287.1 

    8 DOTS entries:

    DT.40114875  DT.101976578  DT.86849036  DT.95141850  DT.121352753  DT.91970856  DT.95121641  DT.40125647 

    24/154 AceView cDNA sequences (see all 154 ):

    AI479031 AA743771 AA281635 AI439553 AA732513 AI434224 AW512632 BI966014 
    BF511316 BE646438 BG494616 AA769441 AI638155 BG055089 AI865238 BI966187 
    AA806272 AI440057 AA281696 AW001912 BC006401 AA832318 AA744586 AI762709 

    highest scoring ESTs for FAIM3:

    AF057557 AI084226 AU098657 BC006401 BE243970 BE244074 BF238303 BF663598 BF975138 BF975657 

    Unigene Cluster for FAIM3:

    Fas apoptotic inhibitory molecule 3
    Hs.58831  [show with all ESTs]
    Unigene Representative Sequence: NM_005449


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000367091  

    Expression
    for FAIM3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAIM3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAIM3

    1 / 2 / 3

    8 probe-sets matching FAIM3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32967_at2, 3 U95-A 1 1.00 1.00 0.95 0.99 AF057557 0.80 0.70 0.75 1
    53196_at2, 3 U95-B 1 1.00 1.00 0.98 1.08 AI084226 0.60 0.62 0.61 1
    53197_g_at2, 3 U95-B 1 1.00 1.00 0.98 1.26 AI084226 0.60 0.62 0.61 1
    41847_at2, 3 U95-A 2 1.00 0.97 0.97 0.68 AA214546 0.40 0.38 0.39 2

    		221602_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF057557 0.80 0.70 0.75 1

    		221601_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI084226 0.60 0.62 0.61 1

    		221602_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		221601_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FAIM3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.58831

    Expression variation in blood from EXPOLDB for FAIM3

    UniProtKB/Swiss-Prot: FAIM3_HUMAN, O60667
    Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and
    kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in
    lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells.
    No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela
    cells

    Orthologs
    for FAIM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for FAIM3 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 FAIM31   -- Fas apoptotic inhibitory molecule 3 79.38(n)
    67.73(a)    		 490266  XM_547385.2  XP_547385.2 
    chimpanzee
    (Pan troglodytes)    		 FAIM31   -- Fas apoptotic inhibitory molecule 3 99.4(n)
    99.74(a)    		 744231  XM_001165341.1  XP_001165341.1 
    cow
    (Bos taurus)    		 FAIM31   -- Fas apoptotic inhibitory molecule 3 77.92(n)
    67.01(a)    		 511564  XM_588921.3  XP_588921.3 
    rat
    (Rattus norvegicus)    		 Faim31   -- Fas apoptotic inhibitory molecule 3 71.68(n)
    58.55(a)    		 548326  NM_001014843.1  NP_001014843.1 
    mouse
    (Mus musculus)    		 Faim31, 5 15
    		 Fas apoptotic inhibitory molecule 31, 5 72.95(n)1
    60.72(a)1    		 691691  NM_026976.21  NP_081252.11 
     AK0077145  AK1559435  (see all 17)
    About this table        Species with no ortholog for FAIM3

    ENSEMBL Gene Tree for FAIM3

    Paralogs
    for FAIM3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FAIM3 gene
    FCAMR2  PIGR2  

    SNPs/Variants
    for FAIM3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/118 NCBI SNPs in FAIM3 are shown (see all 118 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 82)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs14009871,2
    		A,C,F,H,O205163373(-) CTTGGC/ACCATT 1 -- ng31 tfbs310Minor allele frequency- A:0.40MN EU WA NA EA 922
    rs2910841,2
    		A,C,F,H,O205162246(+) AAGAGC/GCTTAT 1 -- ng3122Minor allele frequency- G:0.33EA NA MN EU WA 3650
    rs170178361,2
    		C,F,H205162174(+) CCTCCC/TGTGCT 1 -- ng3111Minor allele frequency- T:0.14NA EU EA WA 966
    rs2910861,2
    		A,C,H205163694(+) ctgagG/Atgtgt 1 -- ng314Minor allele frequency- A:0.00EU EA WA 418
    rs2910851,2
    		C,F,H205162376(+) CACCTA/TCTATG 1 -- ng314Minor allele frequency- T:0.27EU EA WA 416
    rs37623481,2
    		F,H205162479(+) GATCCC/GTGCCA 1 -- ng314Minor allele frequency- G:0.02EU EA WA 418
    rs30934401,2
    		F,H205144820(+) GGGGGC/AAGAGC 1 -- ut31 ese36Minor allele frequency- A:0.00NS EU EA WA 506
    rs1823641,2
    		H205163491(+) CACAGC/GTGGGC 1 -- ng315Minor allele frequency- G:0.00MN EU EA WA 604
    rs120744211,2
    		H205162089(+) CAAAAG/AGCATC 1 -- ng314Minor allele frequency- A:0.00EU EA WA 406
    --
    rs175520521,2
    		F205162703(-) CTGAAG/AGAGAG 1 -- ng312Minor allele frequency- A:0.07EA MN 400
    About this table

    HapMap Linkage Disequilibrium images for FAIM3 (up to first 250kb)

    Disorders & Mutations
    for FAIM3

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 606015

    Medical News
    for FAIM3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for FAIM3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10 PubMed articles for FAIM3 gene:

    Search for FAIM3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAIM3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 9214 HGNC: 14315 AceView: TOSO Ensembl:ENSG00000162894 euGenes: HUgn9214
    ECgene: FAIM3 H-InvDB: FAIM3

    Other Databases showing FAIM3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing FAIM3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for FAIM3 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for FAIM3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for FAIM3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAIM3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAIM3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAIM3 Antibodies for FAIM3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FAIM3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
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     Recombinant Proteins
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     Antibodies (FAIM3)
     Search OriGene for FAIM3
     Search Tocris compounds for FAIM3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FAIM3

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