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FAIM2 Gene

protein-coding   GIFtS: 53

GC12M048546
Fas apoptotic inhibitory molecule 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA0950 1, 2, 3
LFG 1, 2, 3, 5
LIFEGUARD 1
NGP35 2
NMP35 1, 2, 5
TMBIM2 1, 2, 3
lifeguard 2
Descriptions
Fas apoptotic inhibitory molecule 2 2
Protein lifeguard 3
Transmembrane BAX inhibitor motif-containing protein 2 3
neural membrane protein 35 2
transmembrane BAX inhibitor motif containing 2 2
External Ids
HGNC: 170671
Entrez Gene: 230172
UniProtKB: Q9BWQ83
Ensembl: ENSG000001354727
Search outside databases for aliases for FAIM2 gene

Previous GC identifers: GC12M050517 GC12M050316 GC12M049977

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8
Function: Protects cells uniquely from Fas-induced apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAIM2 gene  

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

FAIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048546:     (about GC identifiers)

Start:
48,546,947 bp from pter
End:
48,583,987 bp from pter
Size:
37,041 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8 (See protein sequence)
Recommended Name: Fas apoptotic inhibitory molecule 2  
Size: 316 amino acids; 35110 Da
Subunit: Interacts with TNFRSF6
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction,
synapse, postsynaptic cell membrane (By similarity)
Sequence caution: Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130;
Secondary accessions: Q9UJY9 Q9Y2F7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_036438.2  

    ENSEMBL proteins: 
    ENSP00000321951 


    Human Recombinant Proteins 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FAIM2)
    Human Recombinant Proteins from Abnova (FAIM2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    GO:0030054 cell junction IEA--
    GO:0045202 synapse IEA--
    GO:0045211 postsynaptic membrane IEA--
    About this table

    Antibodies for FAIM2: 
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    Antibodies from Abcam (FAIM2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FAIM2)
    Novus Biologicals Antibodies for FAIM2

    Assays for FAIM2: 
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    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR006214 UPF0005


       GeneDecks  FAIM2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BWQ8

    ProtoNet protein and cluster: Q9BWQ8

    UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8
    Similarity: Belongs to the BI1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAIM2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FAIM2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012306

                  Applied Biosystems Silencer® siRNAs for FAIM2

                  Sigma-Aldrich siRNA for FAIM2  
                         Sigma-Aldrich shRNA for FAIM2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAIM2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_012306
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_012306
                                     untagged cDNA clone in CMV expression vector: NM_012306 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_012306

    UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8
    Function: Protects cells uniquely from Fas-induced apoptosis

    4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Faim2):

    behavior/neurologicalhomeostasis/metabolismnervous systemrenal/urinary system

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding NAS16964429
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for FAIM2 (ENSP000003219513) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASENSP000003609423STRING (score=.973)
    BAXENSP000002932883STRING (score=.869)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915 apoptosis IEA--
    GO:0006916 anti-apoptosis NAS10535980
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAIM2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAIM2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FAIM2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012306

                  Sigma-Aldrich siRNA for FAIM2  
                         Sigma-Aldrich shRNA for FAIM2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_012306  

    REFSEQ mRNAs for FAIM2 gene: 

    NM_012306.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_012306  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_012306
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_012306
                                     untagged cDNA clone in CMV expression vector: NM_012306 

    Additional cDNA sequence: 

    AB023167.1 AF190461.1 AK090728.1 AK290031.1 BC000051.2 BX647219.1 CR599086.1 CR615096.1 
    CR615657.1 CR622004.1 CR624617.1 

    6 DOTS entries:

    DT.448734  DT.100756470  DT.100772514  DT.75159893  DT.92035070  DT.121190998 

    24/221 AceView cDNA sequences (see all 221 ):

    BQ272446 CB153566 AW875497 AL133893 BQ549581 NM_012306 AL118922 CK300444 
    BU074238 BX376124 BQ717776 CR624617 BC000051 BU069526 BQ267406 CR615096 
    AL707764 BX395327 BU782593 CB850833 CD674724 CD675343 AA682932 BI827282 

    highest scoring ESTs for FAIM2:

    AB023167 AA323285 AA326240 AA326352 AI816315 AL707764 AW160990 BE260801 BE262234 BF347922 

    Unigene Cluster for FAIM2:

    Fas apoptotic inhibitory molecule 2
    Hs.567424  [show with all ESTs]
    Unigene Representative Sequence: NM_012306


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000320634  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAIM2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAIM2

    1 / 2 / 3

    5 probe-sets matching FAIM2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33293_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB023167 1.00 0.90 0.95 1

    203619_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012306 0.60 1.00 0.82 1

    203618_at2, 3 U133-A 1 1.00 1.00 -- -- AB023167 1.00 0.90 0.95 1

    203619_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    203618_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FAIM2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGGCTGGAGG

    SOURCE GeneReport for Unigene cluster: Hs.567424

    Expression variation in blood from EXPOLDB for FAIM2

    UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8
    Tissue specificity: Widely expressed. Expressed at high levels in the brain especially in the
    hippocampus

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FAIM2 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FAIM21   -- Fas apoptotic inhibitory molecule 2 90.28(n)
    93.59(a)
    477613  XM_534807.2  XP_534807.2 
    chimpanzee
    (Pan troglodytes)
    FAIM21   -- Fas apoptotic inhibitory molecule 2 99.68(n)
    100(a)
    451885  XM_509050.2  XP_509050.2 
    cow
    (Bos taurus)
    FAIM21   -- Fas apoptotic inhibitory molecule 2 91.98(n)
    94.94(a)
    509790  NM_001075418.1  NP_001068886.1 
    rat
    (Rattus norvegicus)
    Faim21   -- Fas apoptotic inhibitory molecule 2 89.14(n)
    92.72(a)
    246274  NM_144756.2  NP_653357.1 
    mouse
    (Mus musculus)
    Faim21, 5 155
    Fas apoptotic inhibitory molecule 21, 5 88.61(n)1
    92.09(a)1
    723931  NM_028224.31  NP_082500.21 
     AF4680285  AI8355155  (see all 16)
    About this table        Species with no ortholog for FAIM2

    ENSEMBL Gene Tree for FAIM2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FAIM2 gene
    TMBIM42  TMBIM12  GRINA2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/256 NCBI SNPs in FAIM2 are shown (see all 256 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 121)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs14541931,2
    A,C,F,H,O48548036(-) CACACG/ACATCA 1 -- ut31 ese35Minor allele frequency- A:0.41MN EU EA WA 602
    rs48985411,2
    A,C,F,H48548439(+) AGCCCG/ACTGGC 1 -- ut31 ese34Minor allele frequency- A:0.24EU EA WA 420
    rs65807231,2
    A,C,F,H48547741(+) AAATGT/CGAAGG 1 -- ut314Minor allele frequency- C:0.02EU EA WA 406
    rs71329081,2
    A,C,F,H48549415(+) ACTCTG/AGGCTG 1 -- ut31 ese34Minor allele frequency- A:0.30EU EA WA 408
    rs7067951,2
    A,C,F,H48583937(-) TTGCTA/GGAACC 1 -- ut514Minor allele frequency- G:0.36EU EA WA 390
    rs26550601,2
    A,C,F,H48584802(-) TGATGG/ACTGGG 1 -- ng3110Minor allele frequency- A:0.32EU EA WA NA 1014
    rs10647221,2
    A,C,F48547596(-) GGGCCA/CGGGAG 1 -- ut31 ese31Minor allele frequency- C:0.13MN 184
    rs32057181,2
    A,C,F48548076(-) TGGGGG/AAGGAG 1 -- ut31 ese3 trp31Minor allele frequency- A:0.45MN 184
    --
    rs2979161,2
    A,C48585585(-) aggcaC/Tggtgg 1 -- ng310--------
    rs10446771,2
    A,C48547092(-) AGGCCA/GGCTGC 1 -- ut31 ese31Minor allele frequency- G:0.00MN 184
    About this table

    HapMap Linkage Disequilibrium images for FAIM2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604306

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10 PubMed articles for FAIM2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23017 HGNC: 17067 AceView: FAIM2 Ensembl:ENSG00000135472 euGenes: HUgn23017
    ECgene: FAIM2 H-InvDB: FAIM2
    (According to HUGE)
    About This Section

    HUGE: KIAA0950
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAIM2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for FAIM2 Antibodies for FAIM2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FAIM2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FAIM2

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