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Aliases & Descriptions for FAIM2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0950 1, 2, 3 | | LFG 1, 2, 3, 5 | | LIFEGUARD 1 | | NGP35 2 | | NMP35 1, 2, 5 | | TMBIM2 1, 2, 3 | | lifeguard 2 |
| | | Descriptions |
|---|
| Fas apoptotic inhibitory molecule 2 2 | | Protein lifeguard 3 | | Transmembrane BAX inhibitor motif-containing protein 2 3 | | neural membrane protein 35 2 | | transmembrane BAX inhibitor motif containing 2 2 |
|
| | Search outside databases for aliases for FAIM2 genePrevious GC identifers: GC12M050517 GC12M050316 GC12M049977 |
Summaries for FAIM2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8Function: Protects cells uniquely from Fas-induced apoptosis |
Genomic Location for FAIM2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FAIM2 gene 
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13FAIM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M048546:
(about GC identifiers)
Start:
|
48,546,947 bp from pter |
End:
|
48,583,987 bp from pter |
Size:
|
37,041 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for FAIM2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8 (See
protein sequence)Recommended Name: Fas apoptotic inhibitory molecule 2 Size: 316 amino acids; 35110 Da
Subunit: Interacts with TNFRSF6
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity)
Sequence caution: Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130;
Secondary accessions: Q9UJY9 Q9Y2F7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036438.2
ENSEMBL proteins: ENSP00000321951
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for FAIM2: Assays for FAIM2: | Protein
Domains/ Families for FAIM2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BWQ8
ProtoNet protein and cluster: Q9BWQ8 UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8Similarity: Belongs to the BI1 family | Gene Function for FAIM2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012306
Applied Biosystems Silencer® siRNAs for FAIM2
Sigma-Aldrich siRNA for FAIM2  Sigma-Aldrich shRNA for FAIM2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012306                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012306                                  untagged cDNA clone in CMV expression vector: NM_012306 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012306
UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8Function: Protects cells uniquely from Fas-induced apoptosis4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Faim2):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for FAIM2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for FAIM2 (ENSP000003219513) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FAIM2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FAIM2
|
Transcripts for FAIM2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012306
Sigma-Aldrich siRNA for FAIM2  Sigma-Aldrich shRNA for FAIM2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012306 REFSEQ mRNAs for FAIM2 gene: NM_012306.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012306               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012306                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012306                                  untagged cDNA clone in CMV expression vector: NM_012306  Additional cDNA sequence: AB023167.1 AF190461.1 AK090728.1 AK290031.1 BC000051.2 BX647219.1 CR599086.1 CR615096.1 CR615657.1 CR622004.1 CR624617.1 6 DOTS entries: DT.448734 DT.100756470 DT.100772514 DT.75159893 DT.92035070 DT.121190998 24/221 AceView cDNA sequences (see all 221
):BQ272446 CB153566 AW875497 AL133893 BQ549581 NM_012306 AL118922 CK300444 BU074238 BX376124 BQ717776 CR624617 BC000051 BU069526 BQ267406 CR615096 AL707764 BX395327 BU782593 CB850833 CD674724 CD675343 AA682932 BI827282
highest scoring ESTs for FAIM2:AB023167 AA323285 AA326240 AA326352 AI816315 AL707764 AW160990 BE260801 BE262234 BF347922 Unigene Cluster for FAIM2: Fas apoptotic inhibitory molecule 2 Hs.567424 [show with all ESTs]Unigene Representative Sequence: NM_012306
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000320634
|
Expression for FAIM2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FAIM2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FAIM2
1 / 2 / 3 5 probe-sets matching FAIM2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGCTGGAGG
SOURCE GeneReport for Unigene cluster: Hs.567424
Expression variation in blood from EXPOLDB for FAIM2 UniProtKB/Swiss-Prot: FAIM2_HUMAN, Q9BWQ8Tissue specificity: Widely expressed. Expressed at high levels in the brain especially in the hippocampus |
Orthologs for FAIM2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FAIM2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for FAIM2
ENSEMBL Gene Tree for FAIM2 | Paralogs for FAIM2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FAIM2 gene
- TMBIM42 TMBIM12 GRINA2
|
SNPs/Variants for FAIM2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FAIM2 (up to first 250kb)
|
Disorders & Mutations for FAIM2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604306
|
Medical News for FAIM2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FAIM2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for FAIM2 gene: |
Search for FAIM2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAIM2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FAIM2
(According to HUGE)
About This Section
| |
Specialized Databases showing FAIM2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FAIM2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FAIM2:

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Incremental update: 13 Oct 2009
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