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Aliases for FAIM2 Gene

Aliases for FAIM2 Gene

  • Fas Apoptotic Inhibitory Molecule 2 2 3 4
  • NMP35 3 4 6
  • LFG 3 4 6
  • Transmembrane BAX Inhibitor Motif-Containing Protein 2 3 4
  • Neural Membrane Protein 35 3 4
  • TMBIM2 3 4
  • LFG2 3 4
  • Transmembrane BAX Inhibitor Motif Containing 2 2
  • Protein Lifeguard 2 3
  • KIAA0950 4
  • NGP35 3

External Ids for FAIM2 Gene

Summaries for FAIM2 Gene

GeneCards Summary for FAIM2 Gene

FAIM2 (Fas Apoptotic Inhibitory Molecule 2) is a Protein Coding gene. Among its related pathways are FAS (CD95) signaling pathway. An important paralog of this gene is ENSG00000228144.

UniProtKB/Swiss-Prot for FAIM2 Gene

  • Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAIM2 Gene

Genomics for FAIM2 Gene

Genomic Location for FAIM2 Gene

Start:
49,866,896 bp from pter
End:
49,904,217 bp from pter
Size:
37,322 bases
Orientation:
Minus strand

Genomic View for FAIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM2 Gene

Regulatory Elements for FAIM2 Gene

Proteins for FAIM2 Gene

  • Protein details for FAIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWQ8-LFG2_HUMAN
    Recommended name:
    Protein lifeguard 2
    Protein Accession:
    Q9BWQ8
    Secondary Accessions:
    • A8K1W6
    • B3KR08
    • Q9UJY9
    • Q9Y2F7

    Protein attributes for FAIM2 Gene

    Size:
    316 amino acids
    Molecular mass:
    35110 Da
    Quaternary structure:
    • Interacts with FAS/TNFRSF6 and BAX.
    SequenceCaution:
    • Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130; Evidence={ECO:0000305}; Sequence=BAA76794.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAIM2 Gene

Proteomics data for FAIM2 Gene at MOPED

Post-translational modifications for FAIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn191

Other Protein References for FAIM2 Gene

No data available for DME Specific Peptides for FAIM2 Gene

Domains for FAIM2 Gene

Protein Domains for FAIM2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

LFG2_HUMAN
Family:
  • Belongs to the BI1 family. LFG subfamily.:
    • Q9BWQ8
genes like me logo Genes that share domains with FAIM2: view

No data available for Gene Families for FAIM2 Gene

Function for FAIM2 Gene

Molecular function for FAIM2 Gene

UniProtKB/Swiss-Prot Function: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
UniProtKB/Swiss-Prot Induction: Regulated by the AKT1/LEF1 pathway in breast cancer cell lines.
genes like me logo Genes that share phenotypes with FAIM2: view

Animal Models for FAIM2 Gene

MGI Knock Outs for FAIM2:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for FAIM2 Gene

Localization for FAIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM2 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAIM2 Gene COMPARTMENTS Subcellular localization image for FAIM2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FAIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045121 membrane raft IDA 17635665
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with FAIM2: view

Pathways for FAIM2 Gene

SuperPathways for FAIM2 Gene

Superpath Contained pathways
1 FAS (CD95) signaling pathway
genes like me logo Genes that share pathways with FAIM2: view

Pathways by source for FAIM2 Gene

1 BioSystems pathway for FAIM2 Gene

Gene Ontology (GO) - Biological Process for FAIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006915 apoptotic process IEA --
GO:0021549 cerebellum development ISS --
GO:0021680 cerebellar Purkinje cell layer development ISS --
GO:0021681 cerebellar granular layer development ISS --
genes like me logo Genes that share ontologies with FAIM2: view

Transcripts for FAIM2 Gene

Unigene Clusters for FAIM2 Gene

Fas apoptotic inhibitory molecule 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM2 Gene

No ASD Table

Relevant External Links for FAIM2 Gene

GeneLoc Exon Structure for
FAIM2
ECgene alternative splicing isoforms for
FAIM2

Expression for FAIM2 Gene

mRNA expression in normal human tissues for FAIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAIM2 Gene

This gene is overexpressed in Brain - Cortex (6.7), Brain - Frontal Cortex (BA9) (6.0), and Brain - Anterior cingulate cortex (BA24) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAIM2 Gene

SOURCE GeneReport for Unigene cluster for FAIM2 Gene Hs.567424

mRNA Expression by UniProt/SwissProt for FAIM2 Gene

Q9BWQ8-LFG2_HUMAN
Tissue specificity: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.
genes like me logo Genes that share expressions with FAIM2: view

Orthologs for FAIM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAIM2 36
  • 99.68 (n)
  • 100 (a)
FAIM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAIM2 36
  • 91.98 (n)
  • 94.94 (a)
FAIM2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAIM2 36
  • 90.3 (n)
  • 93.99 (a)
FAIM2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faim2 36
  • 88.61 (n)
  • 92.09 (a)
Faim2 16
Faim2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAIM2 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAIM2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faim2 36
  • 89.14 (n)
  • 92.72 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 71 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
LOC101749262 36
  • 75.56 (n)
  • 75.56 (a)
lizard
(Anolis carolinensis)
Reptilia FAIM2 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4832 36
tropical clawed frog
(Silurana tropicalis)
Amphibia faim2 36
  • 67.63 (n)
  • 69.77 (a)
zebrafish
(Danio rerio)
Actinopterygii FAIM2 37
  • 59 (a)
OneToOne
faim2a 36
  • 61.54 (n)
  • 54.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 37
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tag-120 36
  • 48.7 (n)
  • 43.04 (a)
tag-120 37
  • 40 (a)
ManyToMany
xbx-6 37
  • 33 (a)
ManyToMany
Y42H9AR.2 37
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 37
  • 24 (a)
OneToMany
Species with no ortholog for FAIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAIM2 Gene

ENSEMBL:
Gene Tree for FAIM2 (if available)
TreeFam:
Gene Tree for FAIM2 (if available)

Paralogs for FAIM2 Gene

Paralogs for FAIM2 Gene

Selected SIMAP similar genes for FAIM2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FAIM2 Gene

genes like me logo Genes that share paralogs with FAIM2: view

Variants for FAIM2 Gene

Sequence variations from dbSNP and Humsavar for FAIM2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs188459 -- 49,888,661(-) GGCAG(C/T)GGGGC intron-variant
rs188460 -- 49,885,285(-) TTTAC(C/T)TGGCT intron-variant
rs297909 -- 49,903,218(-) TTTTG(C/G)TTTTG intron-variant
rs297910 -- 49,902,855(-) CTCCC(A/G)CCATT intron-variant
rs297911 -- 49,902,518(-) GCACA(A/G)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAIM2 Gene

Variant ID Type Subtype PubMed ID
nsv522972 CNV Gain 19592680
nsv832407 CNV Loss 17160897
esv259454 OTHER Complex 20981092
esv259829 OTHER Complex 20981092
esv8771 CNV Gain 19470904
esv9408 CNV Gain 19470904
esv2568002 CNV Deletion 19546169
esv2745867 CNV Deletion 23290073
esv2745868 CNV Deletion 23290073
esv9667 CNV Loss 19470904
esv2624094 CNV Deletion 19546169
nsv525920 CNV Loss 19592680
esv259988 OTHER Complex 20981092

Relevant External Links for FAIM2 Gene

HapMap Linkage Disequilibrium report
FAIM2

Disorders for FAIM2 Gene

Relevant External Links for FAIM2

Genetic Association Database (GAD)
FAIM2
Human Genome Epidemiology (HuGE) Navigator
FAIM2
genes like me logo Genes that share disorders with FAIM2: view

No data available for UniProtKB/Swiss-Prot for FAIM2 Gene

Publications for FAIM2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. LFG: an anti-apoptotic gene that provides protection from fas- mediated cell death. (PMID: 10535980) Somia N.V. … Verma I.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  3. Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment. (PMID: 17635665) Fernandez M. … Cena V. (J. Neurochem. 2007) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FAIM2 Gene

Sources for FAIM2 Gene

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