Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAIM2 Gene

protein-coding   GIFtS: 55
GCID: GC12M050260

Fas Apoptotic Inhibitory Molecule 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fas Apoptotic Inhibitory Molecule 21 2 3     TMBIM22 3
LFG2 3 5     Transmembrane BAX Inhibitor Motif Containing 21
NMP352 3 5     NGP352
Neural Membrane Protein 352 3     Protein Lifeguard 22
Transmembrane BAX Inhibitor Motif-Containing Protein 22 3     KIAA09503
LFG22 3     

External Ids:    HGNC: 170671   Entrez Gene: 230172   Ensembl: ENSG000001354727   OMIM: 6043065   UniProtKB: Q9BWQ83   

Export aliases for FAIM2 gene to outside databases

Previous GC identifers: GC12M050517 GC12M050316 GC12M049977 GC12M048546 GC12M047291


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAIM2 Gene: 
FAIM2 (Fas apoptotic inhibitory molecule 2) is a protein-coding gene. Diseases associated with FAIM2 include alopecia universalis, and alopecia, and among its related super-pathways are TRAIL signaling pathway. An important paralog of this gene is TMBIM4.

UniProtKB/Swiss-Prot: LFG2_HUMAN, Q9BWQ8
Function: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated
apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by
affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAIM2 gene promoter:
         RP58   Pax-5   Pbx1a   GCNF   RelA   LCR-F1   GCNF-1   GCNF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FAIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

FAIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAIM2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050260:  view genomic region     (about GC identifiers)

Start:
50,260,679 bp from pter      End:
50,298,000 bp from pter
Size:
37,322 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LFG2_HUMAN, Q9BWQ8 (See protein sequence)
Recommended Name: Protein lifeguard 2  
Size: 316 amino acids; 35110 Da
Subunit: Interacts with FAS/TNFRSF6 and BAX
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Membrane raft. Cell junction,
synapse, postsynaptic cell membrane (By similarity)
Sequence caution: Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130; Sequence=BAA76794.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K1W6 Q9UJY9 Q9Y2F7

Explore the universe of human proteins at neXtProt for FAIM2: NX_Q9BWQ8

Explore proteomics data for FAIM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWQ8

  • FAIM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAIM2 Protein Expression
    REFSEQ proteins: NP_036438.2  
    ENSEMBL proteins: 
     ENSP00000321951   ENSP00000450132   ENSP00000447715   ENSP00000446771   ENSP00000449957  
     ENSP00000449711   ENSP00000449360  

    Human Recombinant Protein Products for FAIM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FAIM2
    OriGene Protein Over-expression Lysate for FAIM2
    OriGene MassSpec for FAIM2 
    OriGene Custom Protein Services for FAIM2
    GenScript Custom Purified and Recombinant Proteins Services for FAIM2
    Novus Biologicals FAIM2 Proteins
    Novus Biologicals FAIM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAIM2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0045121membrane raft IDA17635665

    FAIM2 for ontologies           About GeneDecksing



    FAIM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FAIM2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FAIM2
    OriGene Custom Antibody Services for FAIM2
    GenScript Custom Superior Antibodies Services for FAIM2
    Novus Biologicals FAIM2 Antibodies
    Abcam antibodies for FAIM2
    Cloud-Clone Corp. Antibodies for FAIM2 
    ThermoFisher Antibodies for FAIM2
    LSBio Antibodies in human, mouse, rat for FAIM2 

    Assay Products for FAIM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FAIM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FAIM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAIM2 
    Cloud-Clone Corp. CLIAs for FAIM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006214 Bax_inhibitor_1-related

    Graphical View of Domain Structure for InterPro Entry Q9BWQ8

    ProtoNet protein and cluster: Q9BWQ8

    UniProtKB/Swiss-Prot: LFG2_HUMAN, Q9BWQ8
    Similarity: Belongs to the BI1 family. LFG subfamily


    FAIM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LFG2_HUMAN, Q9BWQ8
    Function: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated
    apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by
    affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development
    Induction: Regulated by the AKT1/LEF1 pathway in breast cancer cell lines

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Faim2):

     behavior/neurological  homeostasis/metabolism  nervous system  renal/urinary system 

    FAIM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Faim2tm1.1Jbsc for FAIM2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAIM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAIM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAIM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAIM2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAIM2
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate FAIM2 (see all 47):
    hsa-miR-193a-3p hsa-miR-330-5p hsa-miR-106a hsa-miR-578 hsa-miR-449a hsa-miR-105 hsa-miR-890 hsa-miR-3161
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAIM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAIM2
    Sirion Biotech Validated adenovirus to knockdown FAIM2 in human, mouse 
                         Customized adenovirus for overexpression of FAIM2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FAIM2 (see all 8)
    OriGene ORF clones in mouse, rat for FAIM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAIM2 (NM_012306)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM2
    Sirion Biotech Customized lentivirus for stable overexpression of FAIM2 
                         Customized lentivirus expression plasmids for stable overexpression of FAIM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAIM2
    Search LifeMap BioReagents cell lines for FAIM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FAIM2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TRAIL signaling pathway
    FAS (CD95) signaling pathway0.30


    1 BioSystems Pathway for FAIM2
        FAS (CD95) signaling pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAIM2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAIM2 (Q9BWQ83 ENSP000003219514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASP254453, ENSP000003479794I2D: score=3 STRING: ENSP00000347979
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0021549cerebellum development ISS--
    GO:0021680cerebellar Purkinje cell layer development ISS--
    GO:0021681cerebellar granular layer development ISS--
    GO:0021702cerebellar Purkinje cell differentiation ISS--

    FAIM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAIM2 (LFG2)

    Search CenterWatch for drugs/clinical trials and news about FAIM2 / LFG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAIM2 gene: 
    NM_012306.3  

    Unigene Cluster for FAIM2:

    Fas apoptotic inhibitory molecule 2
    Hs.567424  [show with all ESTs]
    Unigene Representative Sequence: NM_012306
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320634(uc001rvi.2 uc001rvj.2) ENST00000550890 ENST00000550195
    ENST00000552669 ENST00000552863 ENST00000550635 ENST00000547871
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAIM2
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate FAIM2 (see all 47):
    hsa-miR-193a-3p hsa-miR-330-5p hsa-miR-106a hsa-miR-578 hsa-miR-449a hsa-miR-105 hsa-miR-890 hsa-miR-3161
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAIM2
    Clone
    Products:
         
    OriGene clones in human, mouse for FAIM2 (see all 8)
    OriGene ORF clones in mouse, rat for FAIM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAIM2 (NM_012306)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM2
    Sirion Biotech Customized lentivirus for stable overexpression of FAIM2 
                         Customized lentivirus expression plasmids for stable overexpression of FAIM2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAIM2
    OriGene qSTAR qPCR primer pairs in human, mouse for FAIM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAIM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAIM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAIM2

    Additional mRNA sequence: 

    AB023167.1 AF190461.1 AK090728.1 AK290031.1 BC000051.2 BX647219.1 

    6 DOTS entries:

    DT.448734  DT.100756470  DT.75159893  DT.100772514  DT.121190998  DT.92035070 

    24/221 AceView cDNA sequences (see all 221):

    BI827282 BC000051 BX415721 BQ636438 BQ066891 AA349408 BU069526 BM695237 
    CR622004 AI468058 BQ272446 BX376124 AL707764 BM708583 BX395327 CR624617 
    CD674724 CB850833 AI423372 CB152140 AI816238 AA339037 BQ267406 CR615096 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAIM2 expression in normal human tissues (normalized intensities)      FAIM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGGAGG
    FAIM2 Expression
    About this image


    FAIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             Olfactory Bulb   
     
     Heart (Cardiovascular System)
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Fibroblast (Uncategorized)
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   

    See FAIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAIM2

    SOURCE GeneReport for Unigene cluster: Hs.567424

    UniProtKB/Swiss-Prot: LFG2_HUMAN, Q9BWQ8
    Tissue specificity: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of
    the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high
    levels in the brain especially in the hippocampus

        SABiosciences Expression via Pathway-Focused PCR Array including FAIM2: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAIM2
    OriGene qSTAR qPCR primer pairs in human, mouse for FAIM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAIM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAIM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAIM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAIM2 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faim21 , 5 Fas apoptotic inhibitory molecule 21, 5 88.61(n)1
    92.09(a)1
      15 (56.13 cM)5
    723931  NM_028224.31  NP_082500.21 
     994970055 
    chicken
    (Gallus gallus)
    Aves FAIM21 Fas apoptotic inhibitory molecule 2 75.56(n)
    75.56(a)
      426899  XM_424507.3  XP_424507.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAIM26
    Fas apoptotic inhibitory molecule 2
    74(a)
    1 ↔ 1
    2(96044362-96088726)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48322 Xenopus laevis transcribed sequence with weak similarity more 71.06(n)    48040039 
    zebrafish
    (Danio rerio)
    Actinopterygii BM264711.12   -- 71.34(n)    BM264711.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG303796
    --
    27(a)
    possible ortholog
    2R(3827461-3829375)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1201 Protein TAG-120 48.55(n)
    43.04(a)
      179362  NM_073100.5  NP_505501.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BXI16
    Protein involved in apoptosis; variously described...
    23(a)
    1 → many
    XIV(58898-59791)


    ENSEMBL Gene Tree for FAIM2 (if available)
    TreeFam Gene Tree for FAIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAIM2 gene
    TMBIM42  TMBIM12  GRINA2  ENSG000002281442  
    5 SIMAP similar genes for FAIM2 using alignment to 6 protein entries:     LFG2_HUMAN (see all proteins):
    GRINA    RECS1    TMBIM1    TMBIM4    MDS013

    FAIM2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAIM2
    PGOHUM00000232916


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1126 SNPs in FAIM2 are shown (see all 1126)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2979181,2
    C,F,A--47329672(-) CCCGCT/GTCCTC 1 -- int1 tfbs38Minor allele frequency- G:0.34NA WA CSA 250
    rs1825774291,2
    --47329914(+) CGCTTC/GTAACA 1 -- int10--------
    rs1475905721,2
    --47330115(+) ACACCG/TCTAGT 1 -- int10--------
    rs339868971,2
    C,F--47331526(+) TGTGGA/GATGCA 1 -- int15Minor allele frequency- G:0.05NA 218
    rs732934971,2
    C,F--47331745(+) TGGAAA/GTTCTA 1 -- int12Minor allele frequency- G:0.03WA 120
    rs752745101,2
    C,F--47331758(+) GATCAT/CTGCGT 1 -- int11Minor allele frequency- C:0.25EA 120
    rs1865240871,2
    --47331797(+) CTGCTC/GAGACA 1 -- int10--------
    rs118302891,2
    C,F,H--47331811(+) TCTCAG/AGGGTG 1 -- int113Minor allele frequency- A:0.14NS EA NA WA 1202
    rs1917587151,2
    --47331827(+) CCTGAC/TCTTAT 1 -- int10--------
    rs124242681,2
    C,H--47331937(+) ACAtgT/Gtttgt 1 -- int13Minor allele frequency- G:0.09NS EA 358

    HapMap Linkage Disequilibrium report for FAIM2 (50260679 - 50298000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for FAIM2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745867CNV Deletion23290073
    esv2745868CNV Deletion23290073
    esv2624094CNV Deletion19546169
    esv2568002CNV Deletion19546169
    nsv832407CNV Loss17160897
    nsv525920CNV Loss19592680
    esv9667CNV Loss19470904
    nsv522972CNV Gain19592680
    esv8771CNV Gain19470904
    esv9408CNV Gain19470904

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604306    OMIM disorders: --

    6 diseases for FAIM2:    About MalaCards
    alopecia universalis    alopecia    obsessive-compulsive disorder    obesity
    breast cancer    neuronitis


    FAIM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAIM2
    Human Genome Epidemiology (HuGE) Navigator: FAIM2 (9 documents)

    Export disorders for FAIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAIM2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with FAIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LFG: an anti-apoptotic gene that provides protection from fas- mediated cell death. (PubMed id 10535980)1, 2, 3 Somia N.V....Verma I.M. (1999)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. Cumulative effects and predictive value of common obe sity-susceptibility variants identified by genome-wide association studies. (PubMed id 19812171)1, 4 Li S....Loos R.J. (2010)
    4. Implication of genetic variants near NEGR1, SEC16B, T MEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, a nd KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (2010)
    5. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (2010)
    6. The anti-apoptotic protein lifeguard is expressed in breast cancer cells and tissues. (PubMed id 20336406)1, 2 Bucan V....Vogt P.M. (2010)
    7. Associations of six single nucleotide polymorphisms i n obesity-related genes with BMI and risk of obesity in Chinese children. (PubMed id 20843981)1, 4 Wu L....Mi J. (2010)
    8. NRXN3 is a novel locus for waist circumference: a gen ome-wide association study from the CHARGE Consortium. (PubMed id 19557197)1, 4 Heard-Costa N.L....North K.E. (2009)
    9. Association between obesity and polymorphisms in SEC1 6B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 4 Hotta K....Nakamura Y. (2009)
    10. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PubMed id 19079260)1, 4 Thorleifsson G....Stefansson K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23017 HGNC: 17067 AceView: FAIM2 Ensembl:ENSG00000135472 euGenes: HUgn23017
    ECgene: FAIM2 H-InvDB: FAIM2

    (According to HUGE)
    About This Section
    HUGE: KIAA0950

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAIM2 gene:
    Search GeneIP for patents involving FAIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FAIM2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FAIM2   OriGene RNAi products in human, mouse, rat for FAIM2  
     OriGene qPCR primer pairs and template standards for FAIM2   OriGene Protein Over-expression Lysate for FAIM2  
     OriGene MassSpec something-or-other for FAIM2   OriGene clones in human, mouse for FAIM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FAIM2   OriGene Purified Protein for FAIM2  
     OriGene ORF clones in mouse, rat for FAIM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FAIM2   OriGene Custom Protein Services for FAIM2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAIM2
     QIAGEN SeqTarget long-range PCR primers for resequencing FAIM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAIM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAIM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAIM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAIM2
     GenScript Custom Purified and Recombinant Proteins Services for FAIM2 GenScript cDNA clones with any tag delivered in your preferred vector for FAIM2
     GenScript Custom Assay Services for FAIM2 GenScript Custom Superior Antibodies Services for FAIM2
     GenScript Custom overexpressing Cell Line Services for FAIM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FAIM2 promoter
     Search Chromatin IP Primers for FAIM2
     RT2 qPCR Primer Assay in human, mouse, rat FAIM2
     Search GNC Networks for FAIM2
     SABiosciences PCR Arrays including human, mouse, rat FAIM2
     Search Tocris compounds for FAIM2 (LFG2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FAIM2 antibodies
     FAIM2 proteins
     FAIM2 lysates
     Antibodies for FAIM2
     See all of Abcam's Antibodies, Kits and Proteins for FAIM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FAIM2
     Antibodies for FAIM2
     ELISAs for FAIM2
     CLIAs for FAIM2
     Search LifeMap BioReagents cell lines for FAIM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAIM2
     SwitchGear Promoter luciferase reporter plasmids for FAIM2
     ThermoFisher Antibodies for FAIM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAIM2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAIM2
     Validated adenovirus to knockdown FAIM2 in human, mouse

    Customized:
     lentivirus for stable overexpression of FAIM2
     lentivirus expression plasmids for stable overexpression of FAIM2
     adenovirus for overexpression of FAIM2
     LSBio Antibodies in human, mouse, rat for FAIM2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FAIM2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4