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Aliases for FAIM2 Gene

Aliases for FAIM2 Gene

  • Fas Apoptotic Inhibitory Molecule 2 2 3 4 5
  • Transmembrane BAX Inhibitor Motif-Containing Protein 2 3 4
  • Neural Membrane Protein 35 3 4
  • TMBIM2 3 4
  • NMP35 3 4
  • LFG2 3 4
  • LFG 3 4
  • Transmembrane BAX Inhibitor Motif Containing 2 2
  • Protein Lifeguard 2 3
  • KIAA0950 4
  • NGP35 3

External Ids for FAIM2 Gene

Previous GeneCards Identifiers for FAIM2 Gene

  • GC12M050517
  • GC12M050316
  • GC12M049977
  • GC12M048546
  • GC12M050260
  • GC12M047291

Summaries for FAIM2 Gene

GeneCards Summary for FAIM2 Gene

FAIM2 (Fas Apoptotic Inhibitory Molecule 2) is a Protein Coding gene. Among its related pathways are Dimerization of procaspase-8. An important paralog of this gene is TMBIM1.

UniProtKB/Swiss-Prot for FAIM2 Gene

  • Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAIM2 Gene

Genomics for FAIM2 Gene

Regulatory Elements for FAIM2 Gene

Enhancers for FAIM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G049902 1 ENCODE dbSUPER 33.2 +0.5 514 2.7 CTCF ZNF223 RAD21 ZKSCAN1 ZFHX2 FOXK2 PATZ1 PRDM10 ZBTB20 EGR2 FAIM2 GC12M049898
GH12G049909 1.1 ENCODE dbSUPER 25.6 -5.7 -5726 0.9 TBP PKNOX1 ZBTB40 EGR1 FOS CREM DEK EGR2 ZNF263 SMARCC1 FAIM2 LINC02396
GH12G049661 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +240.5 240450 4.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF302 ZNF143 DDX23 LOC390314 KANSL2 LIMA1 CCNT1 ENSG00000257298 FMNL3 LOC101927267 MCRS1 BCDIN3D-AS1
GH12G049055 1.8 FANTOM5 ENCODE dbSUPER 12.6 +845.7 845715 6.7 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 DDX23 LOC390314 CCNT1 KANSL2 SENP1 PRPF40B DDN LOC100422296 LOC101927267 CCDC184
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAIM2 on UCSC Golden Path with GeneCards custom track

Promoters for FAIM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051689 217 401 MAZ JUND ZNF223 PRDM10 KDM1A ZNF398 EZH2

Genomic Location for FAIM2 Gene

49,866,896 bp from pter
49,904,217 bp from pter
37,322 bases
Minus strand

Genomic View for FAIM2 Gene

Genes around FAIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM2 Gene

Proteins for FAIM2 Gene

  • Protein details for FAIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 2
    Protein Accession:
    Secondary Accessions:
    • A8K1W6
    • B3KR08
    • Q9UJY9
    • Q9Y2F7

    Protein attributes for FAIM2 Gene

    316 amino acids
    Molecular mass:
    35110 Da
    Quaternary structure:
    • Interacts with FAS/TNFRSF6 and BAX.
    • Sequence=AAF06327.1; Type=Frameshift; Positions=82, 130; Evidence={ECO:0000305}; Sequence=BAA76794.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAIM2 Gene


neXtProt entry for FAIM2 Gene

Post-translational modifications for FAIM2 Gene

  • Glycosylation at Asn191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAIM2 Gene

Domains & Families for FAIM2 Gene

Gene Families for FAIM2 Gene

Protein Domains for FAIM2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with FAIM2: view

Function for FAIM2 Gene

Molecular function for FAIM2 Gene

UniProtKB/Swiss-Prot Function:
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
UniProtKB/Swiss-Prot Induction:
Regulated by the AKT1/LEF1 pathway in breast cancer cell lines.
genes like me logo Genes that share phenotypes with FAIM2: view

Animal Models for FAIM2 Gene

MGI Knock Outs for FAIM2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAIM2 Gene

Localization for FAIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM2 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAIM2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
endoplasmic reticulum 3
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FAIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAIM2: view

Pathways & Interactions for FAIM2 Gene

SuperPathways for FAIM2 Gene

SuperPathway Contained pathways
1 Dimerization of procaspase-8
genes like me logo Genes that share pathways with FAIM2: view

Pathways by source for FAIM2 Gene

1 BioSystems pathway for FAIM2 Gene

Interacting Proteins for FAIM2 Gene

Gene Ontology (GO) - Biological Process for FAIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006915 apoptotic process IEA --
GO:0021549 cerebellum development ISS --
GO:0021680 cerebellar Purkinje cell layer development ISS --
GO:0021681 cerebellar granular layer development ISS --
genes like me logo Genes that share ontologies with FAIM2: view

No data available for SIGNOR curated interactions for FAIM2 Gene

Drugs & Compounds for FAIM2 Gene

No Compound Related Data Available

Transcripts for FAIM2 Gene

Unigene Clusters for FAIM2 Gene

Fas apoptotic inhibitory molecule 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM2 Gene

No ASD Table

Relevant External Links for FAIM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAIM2 Gene

mRNA differential expression in normal tissues according to GTEx for FAIM2 Gene

This gene is overexpressed in Brain - Cortex (x6.7), Brain - Frontal Cortex (BA9) (x6.0), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for FAIM2 Gene

This gene is overexpressed in Frontal cortex (45.8) and Spinal cord (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAIM2 Gene

Protein tissue co-expression partners for FAIM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAIM2 Gene:


SOURCE GeneReport for Unigene cluster for FAIM2 Gene:


mRNA Expression by UniProt/SwissProt for FAIM2 Gene:

Tissue specificity: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.

Evidence on tissue expression from TISSUES for FAIM2 Gene

  • Nervous system(5)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with FAIM2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAIM2 Gene

Orthologs for FAIM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAIM2 34 35
  • 99.68 (n)
(Bos Taurus)
Mammalia FAIM2 34 35
  • 91.98 (n)
(Canis familiaris)
Mammalia FAIM2 34 35
  • 90.3 (n)
(Rattus norvegicus)
Mammalia Faim2 34
  • 89.14 (n)
(Mus musculus)
Mammalia Faim2 34 16 35
  • 88.61 (n)
(Monodelphis domestica)
Mammalia FAIM2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia FAIM2 35
  • 63 (a)
(Gallus gallus)
Aves -- 35
  • 76 (a)
LOC101749262 34
  • 75.56 (n)
-- 35
  • 71 (a)
(Anolis carolinensis)
Reptilia FAIM2 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia faim2 34
  • 67.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4832 34
(Danio rerio)
Actinopterygii faim2a 34
  • 61.54 (n)
FAIM2 35
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmda1 35
  • 34 (a)
(Caenorhabditis elegans)
Secernentea tag-120 34 35
  • 48.7 (n)
Y42H9AR.2 35
  • 35 (a)
xbx-6 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 35
  • 24 (a)
Species where no ortholog for FAIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAIM2 Gene

Gene Tree for FAIM2 (if available)
Gene Tree for FAIM2 (if available)

Paralogs for FAIM2 Gene

Paralogs for FAIM2 Gene

(5) SIMAP similar genes for FAIM2 Gene using alignment to 6 proteins: Pseudogenes for FAIM2 Gene

genes like me logo Genes that share paralogs with FAIM2: view

Variants for FAIM2 Gene

Sequence variations from dbSNP and Humsavar for FAIM2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000087771 -- 49,905,839(+) CCTTC(C/T)CCCCC upstream-variant-2KB
rs1000116073 -- 49,886,853(+) TGGCT(-/G)GGGGG intron-variant
rs1000129814 -- 49,867,472(+) ATTCC(A/G)GGGCT utr-variant-3-prime
rs1000165773 -- 49,890,303(+) GAGTC(A/T)GGCCT intron-variant
rs1000185899 -- 49,899,679(+) TGACT(G/T)TTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAIM2 Gene

Variant ID Type Subtype PubMed ID
dgv815n106 CNV duplication 24896259
dgv816n106 CNV tandem duplication 24896259
dgv820e59 CNV duplication 20981092
dgv821e59 CNV tandem duplication 20981092
esv2568002 CNV deletion 19546169
esv2624094 CNV deletion 19546169
esv2745867 CNV deletion 23290073
esv2745868 CNV deletion 23290073
esv3303014 CNV tandem duplication 20981092
esv3388362 CNV duplication 20981092
esv8771 CNV gain 19470904
esv9408 CNV gain 19470904
esv9667 CNV loss 19470904
nsv1071030 CNV deletion 25765185
nsv1076390 CNV duplication 25765185
nsv1120258 CNV tandem duplication 24896259
nsv1122730 CNV deletion 24896259
nsv1125546 CNV tandem duplication 24896259
nsv1129160 CNV insertion 24896259
nsv1139657 CNV deletion 24896259
nsv1145601 CNV deletion 24896259
nsv1146546 CNV duplication 26484159
nsv522972 CNV gain 19592680
nsv525920 CNV loss 19592680
nsv558835 CNV gain 21841781
nsv558836 CNV loss 21841781
nsv832407 CNV loss 17160897
nsv952178 CNV deletion 24416366

Variation tolerance for FAIM2 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAIM2 Gene

Disorders for FAIM2 Gene

Relevant External Links for FAIM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAIM2 Gene

Publications for FAIM2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. LFG: an anti-apoptotic gene that provides protection from fas- mediated cell death. (PMID: 10535980) Somia N.V. … Verma I.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 64
  3. The anti-apoptotic protein lifeguard is expressed in breast cancer cells and tissues. (PMID: 20336406) Bucan V. … Vogt P.M. (Cell. Mol. Biol. Lett. 2010) 3 4 64
  4. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) MelAcn E. … Lasky-Su J. (J. Allergy Clin. Immunol. 2010) 3 46 64
  5. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. (PMID: 20843981) Wu L. … Mi J. (Diabetes 2010) 3 46 64

Products for FAIM2 Gene

Sources for FAIM2 Gene

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