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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAIM Gene

protein-coding GIFtS: 51
GCID: GC03P138327

Fas apoptotic inhibitory molecule

Explore 4 diseases affiliated with
FAIM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fas Apoptotic Inhibitory Molecule¹ ²
FAIM1¹ ² ³
FLJ10582¹
Fas Apoptotic Inhibitory Molecule 1²

External Ids:	HGNC: 18703¹	Entrez Gene: 55179²	Ensembl: ENSG00000158234⁷	UniProtKB: Q9NVQ4³

Export aliases for FAIM gene to outside databases

Previous GC identifers: GC03P135281 GC03P139129 GC03P139609 GC03P139648 GC03P139810 GC03P135702

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAIM:

The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and

differentiation. Several transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4

Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement

in B cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAIM gene promoter:
CREB MZF-1 AML1a deltaCREB Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAIM promoter sequence

Search SABiosciences Chromatin IP Primers for FAIM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAIM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3 Ensembl cytogenetic band: 3q22.3 HGNC cytogenetic band: 3q23

FAIM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAIM gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P138327: view genomic region (about GC identifiers)

Start:	138,327,448 bp from pter	End:	138,352,218 bp from pter
Size:	24,771 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4 (See protein sequence)

Recommended Name: Fas apoptotic inhibitory molecule 1

Size: 179 amino acids; 20215 Da

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=BAC86174.1; Type=Miscellaneous discrepancy; Note=Intron retention;

2 PDB 3D structures from and Proteopedia for FAIM:

2KW1 (3D)

3MX7 (3D)

Secondary accessions: Q6IAN2

Alternative splicing: 3 isoforms: Q9NVQ4-1 Q9NVQ4-2 Q9NVQ4-3

Explore the universe of human proteins at neXtProt for FAIM: NX_Q9NVQ4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NVQ4

FAIM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001028202.1 NP_001028203.1 NP_001028204.1 NP_060617.1

ENSEMBL proteins:

ENSP00000342805 ENSP00000353775 ENSP00000376755 ENSP00000376754 ENSP00000417642

ENSP00000420543

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FAIM OriGene Protein Over-expression Lysate (see all 3): FAIM OriGene Custom Protein Services for FAIM
	GenScript Custom Purified and Recombinant Proteins Services for FAIM
	Novus Biologicals FAIM Proteins Novus Biologicals FAIM Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FAIM

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

FAIM for ontologies About GeneDecksing

FAIM Antibody Products:

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	OriGene Antibodies (see all 2): FAIM OriGene Custom Antibody Services for FAIM
	GenScript Custom Superior Antibodies Services for FAIM
	Novus Biologicals FAIM Antibodies
	Search for Antibodies for FAIM at Abcam
	Uscn Antibodies for FAIM
	ThermoFisher Antibodies for FAIM

Assay Products for FAIM:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FAIM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FAIM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAIM for domains About GeneDecksing

1 InterPro domain/family:

IPR010695 FAIM

Graphical View of Domain Structure for InterPro Entry Q9NVQ4

ProtoNet protein and cluster: Q9NVQ4

1 Blocks protein family: IPB010695 Fas apoptotic inhibitory molecule

UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4

Similarity: Belongs to the FAIM1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4

Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement

in B cells (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): FAIM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAIM
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate FAIM:
		hsa-miR-323-3p hsa-miR-140-3p hsa-miR-133a hsa-miR-133b
		SwitchGear 3'UTR luciferase reporter plasmid: FAIM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAIM (see all 7) OriGene shRNA RFP: FAIM OriGene siRNA: FAIM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAIM

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FAIM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAIM (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAIM (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FAIM (NM_005449)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FAIM
		Search LifeMap BioReagents cell lines for FAIM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM

1 GenomeRNAi human phenotype for FAIM:

Synthetic lethal with cisplati

Animal Models:
Mouse knock-out Faim^tm1Kplm for FAIM
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Faim):

cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	mortality/aging

FAIM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Neurotrophic factor-mediated Trk receptor signaling

Neurotrophic factor-mediated Trk receptor signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for FAIM

Apoptosis and Autophagy

1 BioSystems Pathway for FAIM

Neurotrophic factor-mediated Trk receptor signaling

FAIM for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAIM

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for FAIM (Q9NVQ4³ ENSP00000342805⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GMPS	P49915³	I2D: score=2
NGF	ENSP00000358525⁴	STRING: ENSP00000358525

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0043066	negative regulation of apoptotic process	IEA	--

FAIM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAIM
Search CenterWatch for drugs/clinical trials and news about FAIM / FAIM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAIM gene (4 alternative transcripts):

NM_001033030.1 NM_001033031.1 NM_001033032.1 NM_018147.3

Unigene Cluster for FAIM:

Fas apoptotic inhibitory molecule

Hs.173438 [show with all ESTs]

Unigene Representative Sequence: NM_001033030

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000470889(uc003eso.1) ENST00000338446(uc003esp.3) ENST00000360570(uc003esq.3 uc003esr.3)

ENST00000393035 ENST00000491175 ENST00000393034(uc003ess.3) ENST00000464668

ENST00000479848 ENST00000464912

miRNA Products:		OriGene 3'-UTR Clone (see all 4): FAIM Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAIM
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate FAIM:
		hsa-miR-323-3p hsa-miR-140-3p hsa-miR-133a hsa-miR-133b
		SwitchGear 3'UTR luciferase reporter plasmid: FAIM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAIM (see all 7) OriGene shRNA RFP: FAIM OriGene siRNA: FAIM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAIM

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAIM (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAIM (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FAIM (NM_005449)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAIM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FAIM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAIM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAIM

Additional cDNA sequence:

AK001444.1 BC012478.1 CR457122.1

7 DOTS entries:

DT.100751537 DT.448180 DT.102824326 DT.97843714 DT.91796358 DT.120861339 DT.120861350

24/79 AceView cDNA sequences (see all 79):

AV725889 AA099588 BM831786 BC012478 AI095903 BQ045388 CD677046 BG257592

BG261141 AI339589 BM469375 BM689613 BU689607 BE765628 CA841096 BU738945

AA885228 AI991755 AW118945 BM676763 BM703907 AA477027 BM664076 BM794937

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAIM (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b
SP1:									-				-		-
SP2:									-		-		-		-												-
SP3:									-		-				-
SP4:											-		-		-												-
SP5:			-		-		-		-		-		-		-

ECgene alternative splicing isoforms for FAIM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAIM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACTAACAT

About this image

FAIM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAIM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAIM

SOURCE GeneReport for Unigene cluster: Hs.173438

SABiosciences Expression via Pathway-Focused PCR Arrays including FAIM:

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAIM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FAIM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAIM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAIM

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FAIM gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Faim^{1 , 5}	Fas apoptotic inhibitory molecule^{1, 5}	86.1(n)¹ 91.46(a)¹		9 (51.41 cM)⁵ 23873¹ NM_001122851.1¹ NP_001116323.1¹ 98986373⁵
chicken (Gallus gallus)	Aves	FAIM¹	Fas apoptotic inhibitory molecule	80.82(n) 87.15(a)		424270 XM_422117.2 XP_422117.1
lizard (Anolis carolinensis)	Reptilia	FAIM⁶	--	75(a)	1 ↔ 1	1(77417165-77424653)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.17723²	Transcribed sequence with moderate similarity to protein more	74.21(n)		CF152592.1
zebrafish (Danio rerio)	Actinopterygii	faima¹	Fas apoptotic inhibitory molecule a	72.22(n) 77.01(a)		436856 NM_001002583.1 NP_001002583.1
fruit fly (Drosophila melanogaster)	Insecta	CG10257^{1 , 3}	apoptosis inhibitor³ CG10257¹	37(a)³ 47.8(n)¹ 37.04(a)¹		51D5³ 36671¹ NM_137164.3¹ NP_611008.2¹
worm (Caenorhabditis elegans)	Secernentea	C44B11.1^{1 , 3}	Protein C44B11.1¹	48(a)³ 57.31(n)¹ 52.63(a)¹		III(3227772-3230173)³ 175421¹ NM_065263.3¹ NP_497664.2¹

ENSEMBL Gene Tree for FAIM (if available)
TreeFam Gene Tree for FAIM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114616333^1,2		--	138325685(+)	`CTTAGG/ATTTCA`	3	--	us2k¹		1		NA	120
rs138981082^1,2		--	138325695(+)	`AACATA/GTGAAT`	3	--	us2k¹		0	--	--	--	--
rs59890148^1,2	F,	--	138325787(+)	`TCTCTA/GTTCTA`	3	--	us2k¹		1		WA	118
rs11929612^1,2	C,H	--	138325865(+)	`GCTCTC/TTGTAG`	3	--	us2k¹		4		NS EA	416
rs183435907^1,2		--	138326024(+)	`CCAAGC/TGGCCA`	4	--	us2k¹		0	--	--	--	--
rs115064312^1,2		--	138326116(+)	`AGGGGC/ATAGGA`	4	--	us2k¹		1		WA	118
rs187224012^1,2		--	138326132(+)	`AATCCC/GTGGTG`	4	--	us2k¹		0	--	--	--	--
rs190858382^1,2		--	138326176(+)	`TGAGAC/TGAAGT`	4	--	us2k¹		0	--	--	--	--
rs142121852^1,2		--	138326177(+)	`GAGACG/TAAGTA`	4	--	us2k¹		0	--	--	--	--
rs112572358^1,2		--	138326228(+)	`AGTTCA/GCTGCA`	4	--	us2k¹		1		CSA	1

HapMap Linkage Disequilibrium report for FAIM (138327448 - 138352218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAIM: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAIM

DNA2.0 Custom Variant and Variant Library Synthesis for FAIM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAIM for disorders About GeneDecksing

4 diseases for FAIM: About MalaCards

food allergy hemorrhagic thrombocythemia retinitis neuronitis

1 disease from the University of Copenhagen DISEASES database for FAIM:

Food allergy

Human Genome Epidemiology (HuGE) Navigator: FAIM (3 documents)

Export disorders for FAIM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAIM gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FAIM)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)^{1, 2} Wistow G.... Peterson K. (2002)
A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. (PubMed id 10075978)^{1, 3} Schneider T.J....Rothstein T.L. (1999)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Crystallization and preliminary X-ray crystallographi c studies of human FAIM protein. (PubMed id 20693673)¹ Li G....Zheng X. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Fas apoptosis inhibitory molecule enhances CD40 signa ling in B cells and augments the plasma cell compartment. (PubMed id 19592656)¹ Kaku H. and Rothstein T.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55179	HGNC: 18703	AceView: FAIM	Ensembl:ENSG00000158234	euGenes: HUgn55179
ECgene: FAIM	H-InvDB: FAIM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAIM	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAIM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FAIM gene:
Search GeneIP for patents involving FAIM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
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	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
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	OriGene Antibodies for FAIM		OriGene shRNA RFP for FAIM
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAIM		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAIM
	OriGene Protein Over-expression Lysate for FAIM		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FAIM		OriGene 3'-UTR Clone for FAIM
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAIM		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAIM
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	OriGene Purified Protein for FAIM		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FAIM		OriGene Custom Protein Services for FAIM
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAIM
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAIM
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAIM
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	GenScript Custom Purified and Recombinant Proteins Services for FAIM		GenScript cDNA clones with any tag delivered in your preferred vector for FAIM
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	GenScript Custom overexpressing Cell Line Services for FAIM		CloneReady with Over 120,000 Genes
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Antibodies & Assays for FAIM

	Regulatory tfbs in FAIM promoter
	Search Chromatin IP Primers for FAIM
	RT² qPCR Primer Assay in human, mouse, rat FAIM
	Search GNC Networks for FAIM
	SABiosciences PCR Arrays including human, mouse, rat FAIM

Search Tocris compounds for FAIM

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	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	FAIM proteins
	FAIM lysates

	Search for Antibodies for FAIM at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for FAIM
	Custom Antibody / Protein Production Service
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	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FAIM Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FAIM

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM

	SwitchGear 3'UTR luciferase reporter plasmids for FAIM
	SwitchGear Promoter luciferase reporter plasmids for FAIM

ThermoFisher Antibodies for FAIM

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Fas apoptotic inhibitory molecule

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FAIM Gene

Fas apoptotic inhibitory molecule

Aliasesfor FAIM gene

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Genome Databases showing FAIM gene

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Specialized Databases showing FAIM gene

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for FAIM gene

Genomic Views
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Expression
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Orthologs
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Paralogs
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Genomic Variants
for FAIM gene

Disorders / Diseases
for FAIM gene

Publications
for FAIM gene

Intellectual Property
for FAIM gene

Products
for FAIM gene