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FAIM Gene

protein-coding   GIFtS: 58
GCID: GC03P138327

Fas Apoptotic Inhibitory Molecule

  Search for FAIM
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fas Apoptotic Inhibitory Molecule1 2
FAIM12 3
Fas Apoptotic Inhibitory Molecule 12
FAIM25
LFG5
NMP355

External Ids:    HGNC: 187031   Entrez Gene: 551792   Ensembl: ENSG000001582347   OMIM: 6043065   UniProtKB: Q9NVQ43   
ORGUL members:         

Export aliases for FAIM gene to outside databases

Previous GC identifers: GC03P135281 GC03P139129 GC03P139609 GC03P139648 GC03P139810 GC03P135702


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAIM Gene:
The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell
signaling and differentiation. Several transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for FAIM Gene:
FAIM (Fas apoptotic inhibitory molecule) is a protein-coding gene.

UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4
Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig
engagement in B cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAIM gene promoter:
         CREB   MZF-1   AML1a   deltaCREB   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAIM promoter sequence
   Search Chromatin IP Primers for FAIM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAIM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q23

FAIM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAIM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P138327:  view genomic region     (about GC identifiers)

Start:
138,327,448 bp from pter      End:
138,352,218 bp from pter
Size:
24,771 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4 (See protein sequence)
Recommended Name: Fas apoptotic inhibitory molecule 1  
Size: 179 amino acids; 20215 Da
Sequence caution: Sequence=BAC86174.1; Type=Miscellaneous discrepancy; Note=Intron retention;
2 PDB 3D structures from and Proteopedia for FAIM:
2KW1 (3D)        3MX7 (3D)    
Secondary accessions: Q6IAN2
Alternative splicing: 3 isoforms:  Q9NVQ4-1   Q9NVQ4-2   Q9NVQ4-3   

Explore the universe of human proteins at neXtProt for FAIM: NX_Q9NVQ4

Explore proteomics data for FAIM at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys160
  • Modification sites at PhosphoSitePlus

  • See FAIM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001028202.1  NP_001028203.1  NP_001028204.1  NP_060617.1  

    ENSEMBL proteins: 
     ENSP00000342805   ENSP00000353775   ENSP00000376755   ENSP00000376754   ENSP00000417642  
     ENSP00000420543  

    FAIM Human Recombinant Protein Products:

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    Novus Biologicals FAIM Proteins
    Novus Biologicals FAIM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAIM

     
    Search eBioscience for Proteins for FAIM 

    FAIM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. Antibodies for FAIM
    ThermoFisher Antibody for FAIM
    LSBio Antibodies in human, mouse, rat for FAIM

    FAIM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAIM
    Cloud-Clone Corp. CLIAs for FAIM
    Search eBioscience for ELISAs for FAIM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010695 FAIM

    Graphical View of Domain Structure for InterPro Entry Q9NVQ4

    ProtoNet protein and cluster: Q9NVQ4

    1 Blocks protein domain: IPB010695 Fas apoptotic inhibitory molecule

    UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4
    Similarity: Belongs to the FAIM1 family


    Find genes that share domains with FAIM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAIM1_HUMAN, Q9NVQ4
    Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig
    engagement in B cells (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for FAIM:

     Synthetic lethal with cisplati 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Faim):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging 

    Find genes that share phenotypes with FAIM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Faimtm1Kplm for FAIM

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAIM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAIM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAIM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAIM

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAIM:
    hsa-mir-215-5p (MIRT024307), hsa-mir-9-5p (MIRT021393), hsa-mir-133b (MIRT006650), hsa-mir-192-5p (MIRT026322)

    Block miRNA regulation of human, mouse, rat FAIM using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FAIM:
    hsa-miR-323-3p hsa-miR-140-3p hsa-miR-133a hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidFAIM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAIM
    Predesigned siRNA for gene silencing in human, mouse, rat FAIM

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FAIM

    Clone
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    OriGene clones in human, mouse for FAIM (see all 23)
    OriGene ORF clones in mouse, rat for FAIM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAIM (NM_005449)
    Sino Biological Human cDNA Clone for FAIM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FAIM
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAIM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAIM1_HUMAN, Q9NVQ4: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with FAIM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAIM About    
    See pathways by source

    SuperPathContained pathways About
    1Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    2Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with FAIM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FAIM
        Apoptosis and Autophagy

    1 BioSystems Pathway for FAIM
        Neurotrophic factor-mediated Trk receptor signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including FAIM: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FAIM

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAIM (Q9NVQ43 ENSP000003428054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GMPSP499153I2D: score=2 
    NGFENSP000003585254STRING: ENSP00000358525
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA--

    Find genes that share ontologies with FAIM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAIM (FAIM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAIM gene (4 alternative transcripts): 
    NM_001033030.1  NM_001033031.1  NM_001033032.1  NM_018147.3  

    Unigene Cluster for FAIM:

    Fas apoptotic inhibitory molecule
    Hs.173438  [show with all ESTs]
    Unigene Representative Sequence: NM_001033030
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470889(uc003eso.1) ENST00000338446(uc003esp.3) ENST00000360570(uc003esq.3 uc003esr.3)
    ENST00000393035 ENST00000491175 ENST00000393034(uc003ess.3) ENST00000464668
    ENST00000479848 ENST00000464912
    miRNA
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    Block miRNA regulation of human, mouse, rat FAIM using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate FAIM:
    hsa-miR-323-3p hsa-miR-140-3p hsa-miR-133a hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidFAIM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAIM
    Predesigned siRNA for gene silencing in human, mouse, rat FAIM
    Clone
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    OriGene clones in human, mouse for FAIM (see all 23)
    OriGene ORF clones in mouse, rat for FAIM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FAIM (NM_005449)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAIM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAIM
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAIM
    OriGene qSTAR qPCR primer pairs in human, mouse for FAIM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAIM
      QuantiTect SYBR Green Assays in human, mouse, rat FAIM
      QuantiFast Probe-based Assays in human, mouse, rat FAIM

    Additional mRNA sequence: 

    AK001444.1 BC012478.1 CR457122.1 

    7 DOTS entries:

    DT.100751537  DT.448180  DT.102824326  DT.97843714  DT.91796358  DT.120861339  DT.120861350 

    Selected AceView cDNA sequences (see all 79):

    BE765628 AA099588 AA885228 AI339589 AI745532 BM668657 AW118945 CD677046 
    BU689607 BU738945 BM703907 CB163156 BC012478 AA477027 BM664076 BM689613 
    BQ045388 AA476917 BM661587 BM831413 AI095903 BG257592 CA841096 BG261141 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAIM (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                          -           -     -                                                   
    SP2:                          -     -     -     -                                   -               
    SP3:                          -     -           -                                                   
    SP4:                                -     -     -                                   -               
    SP5:        -     -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for FAIM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAIM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTAACAT
    FAIM Expression
    About this image


    FAIM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
    FAIM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAIM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173438
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FAIM: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAIM
    OriGene qSTAR qPCR primer pairs in human, mouse for FAIM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAIM
    QuantiTect SYBR Green Assays in human, mouse, rat FAIM
    QuantiFast Probe-based Assays in human, mouse, rat FAIM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAIM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAIM gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faim1 , 5 Fas apoptotic inhibitory molecule1, 5 85.41(n)1
    90.55(a)1
      9 (51.41 cM)5
    238731  NM_001122851.11  NP_001116323.11 
     989863735 
    chicken
    (Gallus gallus)
    Aves FAIM1 Fas apoptotic inhibitory molecule 81.06(n)
    86.93(a)
      424270  XM_422117.3  XP_422117.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAIM6
    Fas apoptotic inhibitory molecule
    76(a)
    1 ↔ 1
    1(77411071-77424653)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177232 Transcribed sequence with moderate similarity to protein more 74.21(n)    CF152592.1 
    zebrafish
    (Danio rerio)
    Actinopterygii faima1 Fas apoptotic inhibitory molecule a 72.22(n)
    77.01(a)
      436856  NM_001002583.1  NP_001002583.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102571 , 3 apoptosis inhibitor3
    CG102571
    37(a)3
    47.54(n)1
    36.84(a)1
      51D53
    366711  NM_137164.31  NP_611008.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C44B11.11 , 3 C44B11.11 48(a)3
    57.31(n)1
    52.63(a)1
      III(3227772-3230173)3
    1754211  NM_065263.41  NP_497664.21 


    ENSEMBL Gene Tree for FAIM (if available)
    TreeFam Gene Tree for FAIM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAIM (see all 520)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146163331,2
    C,F--138305142(+) CTTAGG/ATTTCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1389810821,2
    --138305152(+) AACATA/GTGAAT 3 -- us2k10--------
    rs598901481,2
    F--138305243(+) TCTCTA/GTTCTA 3 -- us2k11Minor allele frequency- G:0.04WA 118
    rs119296121,2
    C,H--138305321(+) GCTCTC/TTGTAG 3 -- us2k14Minor allele frequency- T:0.00NS EA 416
    rs1834359071,2
    --138305480(+) CCAAGC/TGGCCA 4 -- us2k10--------
    rs1150643121,2
    F--138305572(+) AGGGGC/ATAGGA 4 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1872240121,2
    --138305588(+) AATCCC/GTGGTG 4 -- us2k10--------
    rs1908583821,2
    --138305632(+) TGAGAC/TGAAGT 4 -- us2k10--------
    rs1421218521,2
    --138305633(+) GAGACG/TAAGTA 4 -- us2k10--------
    rs1125723581,2
    C,F--138305684(+) AGTTCA/GCTGCA 4 -- us2k11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for FAIM (138327448 - 138352218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAIM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428422CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAIM
    DNA2.0 Custom Variant and Variant Library Synthesis for FAIM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604306    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for FAIM:
    Food allergy

    Find genes that share disorders with FAIM           About GenesLikeMe

    Genetic Association Database (GAD): FAIM
    Human Genome Epidemiology (HuGE) Navigator: FAIM (3 documents)

    Export disorders for FAIM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAIM gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with FAIM)
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    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)1, 2 Wistow G.... Peterson K. (Mol. Vis. 2002)
    5. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. (PubMed id 10075978)1, 3 Schneider T.J....Rothstein T.L. (J. Exp. Med. 1999)
    6. Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma. (PubMed id 23138182)1 Huo J....Lam K.P. (Leukemia 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. (PubMed id 20693673)1 Li G....Zheng X. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55179 HGNC: 18703 AceView: FAIM Ensembl:ENSG00000158234 euGenes: HUgn55179
    ECgene: FAIM H-InvDB: FAIM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAIM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FAIM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAIM gene:
    Search GeneIP for patents involving FAIM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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