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FAIM Gene

protein-coding   GIFtS: 53

GC03P139810
Fas apoptotic inhibitory molecule
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FAIM1 1, 2, 3
FLJ10582 1
Descriptions
Fas apoptotic inhibitory molecule 2
External Ids
HGNC: 187031
Entrez Gene: 551792
UniProtKB: Q9NVQ43
Ensembl: ENSG000001582347
Search outside databases for aliases for FAIM gene

Previous GC identifers: GC03P135281 GC03P139129 GC03P139609 GC03P139648

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4
Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by
surface Ig engagement in B cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FAIM gene  

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q23

FAIM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P139810:     (about GC identifiers)

Start:
139,810,232 bp from pter
End:
139,834,908 bp from pter
Size:
24,677 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4 (See protein sequence)
Recommended Name: Fas apoptotic inhibitory molecule 1  
Size: 179 amino acids; 20215 Da
Alternative splicing: 2 isoforms:  Q9NVQ4-1   Q9NVQ4-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001028202.1  NP_001028203.1  NP_001028204.1  NP_060617.1  


    ENSEMBL proteins: 
    ENSP00000342805 ENSP00000376756 ENSP00000353775 ENSP00000376754 ENSP00000376755 ENSP00000311882 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FAIM1)
    Human Recombinant Proteins from Abnova (FAIM)
                  OriGene Purified Recombinant Human Protein: FAIM 


    Antibodies for FAIM: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FAIM
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (FAIM1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FAIM)
    Novus Biologicals Antibody for FAIM

    Assays for FAIM: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR010695 FAIM


       GeneDecks  FAIM for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NVQ4

    ProtoNet protein and cluster: Q9NVQ4

    1 Blocks protein family: IPB010695 Fas apoptotic inhibitory molecule

    UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4
    Similarity: Belongs to the FAIM1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAIM)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001033030

                  Applied Biosystems Silencer® siRNAs for FAIM

                  Sigma-Aldrich siRNA for FAIM  
                         Sigma-Aldrich shRNA for FAIM  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FAIM
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001033030
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001033030
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001033030 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001033030

    UniProtKB/Swiss-Prot: FAIM1_HUMAN, Q9NVQ4
    Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by
    surface Ig engagement in B cells (By similarity)

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for FAIM (ENSP000003428053) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTRK1ENSP000003514863STRING (score=.928)
    NGFENSP000003585253STRING (score=.924)
    NGFRENSP000001722293STRING (score=.871)
    CFLARENSP000003124553STRING (score=.702)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043066 negative regulation of apoptosis IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FAIM

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FAIM)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001033030

                  Sigma-Aldrich siRNA for FAIM  
                         Sigma-Aldrich shRNA for FAIM  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001033030  NM_001033031  NM_001033032  NM_018147  

    REFSEQ mRNAs for FAIM gene (4 alternative transcripts): 

    NM_001033030.1   NM_001033031.1   NM_001033032.1   NM_018147.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001033030  NM_001033031  NM_001033032  NM_018147  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001033030
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001033030
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001033030 

    Additional cDNA sequence: 

    AK001444.1 BC012478.1 CR457122.1 

    8 DOTS entries:

    DT.100751537  DT.448180  DT.102824326  DT.91796358  DT.97843714  DT.120861339  DT.120861350  DT.95152126 

    24/79 AceView cDNA sequences (see all 79 ):

    BG257592 BU689607 AI991755 BM689613 AI095903 BM668657 AA885228 BM676763 
    BQ045388 AV725889 CD677046 AW118945 AI745532 AA099588 BU738945 BM661587 
    CB163156 CA841096 BC012478 BM794937 AA477027 AI339589 BM703907 BE765628 

    highest scoring ESTs for FAIM:

    AI190311 AA026060 AA043990 AA099194 AA099588 AA126463 AA476917 AA477027 AA662664 AA688289 

    Unigene Cluster for FAIM:

    Fas apoptotic inhibitory molecule
    Hs.173438  [show with all ESTs]
    Unigene Representative Sequence: NM_001033030


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAIM (see all 6 )

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                          -           -     -                                                   
    SP2:                          -     -     -     -                                   -               
    SP3:                          -     -           -                                                   
    SP4:                                -     -     -                                   -               
    SP5:        -     -     -     -     -     -     -                                                   

    About this scheme

    ECgene alternative splicing isoforms for FAIM

    6 Ensembl transcripts including schematic representations:
    ENST00000338446  ENST00000393036  ENST00000360570  ENST00000393034  ENST00000393035  ENST00000311126  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FAIM expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FAIM

    1 / 2 / 3

    3 probe-sets matching FAIM gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    48526_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI190311 1.00 1.00 1.00 1

    220643_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018147 0.60 1.00 0.82 1

    220643_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FAIM for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAACTAACAT

    SOURCE GeneReport for Unigene cluster: Hs.173438
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FAIM gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FAIM1   -- Fas apoptotic inhibitory molecule 91.96(n)
    93.97(a)
    485687  XM_542807.2  XP_542807.2 
    chimpanzee
    (Pan troglodytes)
    FAIM1   -- Fas apoptotic inhibitory molecule 99.67(n)
    99.5(a)
    460729  XM_001157144.1  XP_001157144.1 
    cow
    (Bos taurus)
    FAIM1   -- Fas apoptotic inhibitory molecule 92.63(n)
    92.96(a)
    616795  XM_001251481.1  XP_001251482.1 
    rat
    (Rattus norvegicus)
    Faim1   -- Fas apoptotic inhibitory molecule 85.31(n)
    91.53(a)
    140930  NM_080895.1  NP_543171.1 
    mouse
    (Mus musculus)
    Faim1, 5 95
    Fas apoptotic inhibitory molecule1, 5 85.12(n)1
    90.4(a)1
    238731  NM_011810.21  NP_035940.21 
     AF1303675  AK0057625  (see all 11)
    About this table        Species with no ortholog for FAIM

    ENSEMBL Gene Tree for FAIM
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/118 NCBI SNPs in FAIM are shown (see all 118 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 41)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs6413201,2
    C,F,H,O139830647(-) CATAGC/TATCTT 4 A/T mis114Minor allele frequency- G:0.02MN NA EU EA WA 1129
    rs130431,2
    C,F,H,O139830678(-) TCTCCA/GATTTT 4 L/S mis112Minor allele frequency- G:0.16MN NA EU EA WA 1162
    rs119296121,2
    H139808555(+) GCTCTC/TTGTAG 3 -- ng514Minor allele frequency- T:0.00EU EA WA 416
    rs8113221,2
    A,C,F,H,O139812552(+) TCTCCA/GGACTC 4 P/P syn1 int1 ese316Minor allele frequency- G:0.34MN EU EA WA NA 1320
    rs3610731,2
    A,C,F,H,O139829854(-) ACGGGG/ATTTAT 4 -- int18Minor allele frequency- A:0.33MN EU EA WA NA 736
    rs3610751,2
    A,C,F,H,O139827808(-) TCAAAA/GTGGTA 4 -- int17Minor allele frequency- G:0.39EA NA EU WA 372
    rs3610741,2
    A,C,F,H,O139829519(-) TATTAT/CAGTGA 4 -- int112Minor allele frequency- C:0.32MN EU EA WA NA 1292
    rs3610761,2
    A,C,F,H,O139827389(-) gtcagG/Ctctca 4 -- int17Minor allele frequency- C:0.28EU EA WA NA 556
    rs37737481,2
    A,C,F,H139822597(-) TTATTC/ATTCTC 4 -- int1 trp312Minor allele frequency- A:0.31EA NA EU WA 2384
    rs6010321,2
    A,C,F,H139832022(-) ATCTTT/CGTAAC 4 -- int116Minor allele frequency- C:0.07NS NA EU EA WA 1082
    About this table

    HapMap Linkage Disequilibrium images for FAIM (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for FAIM gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55179 HGNC: 18703 AceView: FAIM Ensembl:ENSG00000158234 euGenes: HUgn55179
    ECgene: FAIM H-InvDB: FAIM
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FAIM:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FAIM-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FAIM Antibodies for FAIM
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FAIM Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (FAIM1)
     Antibodies (FAIM1)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for FAIM




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FAIM

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