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Aliases for FAIM Gene

Aliases for FAIM Gene

  • Fas Apoptotic Inhibitory Molecule 2 3 5
  • FAIM1 3 4

External Ids for FAIM Gene

Previous GeneCards Identifiers for FAIM Gene

  • GC03P135281
  • GC03P139129
  • GC03P139609
  • GC03P139648
  • GC03P139810
  • GC03P138327
  • GC03P135702

Summaries for FAIM Gene

Entrez Gene Summary for FAIM Gene

  • The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FAIM Gene

FAIM (Fas Apoptotic Inhibitory Molecule) is a Protein Coding gene. Among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Apoptosis and Autophagy.

UniProtKB/Swiss-Prot for FAIM Gene

  • Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAIM Gene

Genomics for FAIM Gene

Regulatory Elements for FAIM Gene

Enhancers for FAIM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAIM on UCSC Golden Path with GeneCards custom track

Promoters for FAIM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAIM on UCSC Golden Path with GeneCards custom track

Genomic Location for FAIM Gene

Chromosome:
3
Start:
138,608,594 bp from pter
End:
138,633,376 bp from pter
Size:
24,783 bases
Orientation:
Plus strand

Genomic View for FAIM Gene

Genes around FAIM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAIM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM Gene

Proteins for FAIM Gene

  • Protein details for FAIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVQ4-FAIM1_HUMAN
    Recommended name:
    Fas apoptotic inhibitory molecule 1
    Protein Accession:
    Q9NVQ4
    Secondary Accessions:
    • Q6IAN2

    Protein attributes for FAIM Gene

    Size:
    179 amino acids
    Molecular mass:
    20215 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86174.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAIM Gene

    Alternative splice isoforms for FAIM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAIM Gene

Proteomics data for FAIM Gene at MOPED

Post-translational modifications for FAIM Gene

  • Ubiquitination at Lys 47 and Lys 160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAIM Gene

Domains & Families for FAIM Gene

Protein Domains for FAIM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAIM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVQ4

UniProtKB/Swiss-Prot:

FAIM1_HUMAN :
  • Belongs to the FAIM1 family.
Family:
  • Belongs to the FAIM1 family.
genes like me logo Genes that share domains with FAIM: view

No data available for Gene Families for FAIM Gene

Function for FAIM Gene

Molecular function for FAIM Gene

UniProtKB/Swiss-Prot Function:
Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
genes like me logo Genes that share phenotypes with FAIM: view

Animal Models for FAIM Gene

MGI Knock Outs for FAIM:

Animal Model Products

miRNA for FAIM Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAIM Gene

Localization for FAIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAIM Gene COMPARTMENTS Subcellular localization image for FAIM gene
Compartment Confidence
cytosol 4
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for FAIM Gene

Pathways & Interactions for FAIM Gene

genes like me logo Genes that share pathways with FAIM: view

Pathways by source for FAIM Gene

1 Cell Signaling Technology pathway for FAIM Gene
1 BioSystems pathway for FAIM Gene

Interacting Proteins for FAIM Gene

Gene Ontology (GO) - Biological Process for FAIM Gene

None

No data available for SIGNOR curated interactions for FAIM Gene

Drugs & Compounds for FAIM Gene

No Compound Related Data Available

Transcripts for FAIM Gene

Unigene Clusters for FAIM Gene

Fas apoptotic inhibitory molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6:

Relevant External Links for FAIM Gene

GeneLoc Exon Structure for
FAIM
ECgene alternative splicing isoforms for
FAIM

Expression for FAIM Gene

mRNA expression in normal human tissues for FAIM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAIM Gene

This gene is overexpressed in Retina (32.1), Fetal ovary (9.0), and Spinal cord (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAIM Gene



SOURCE GeneReport for Unigene cluster for FAIM Gene Hs.173438

genes like me logo Genes that share expression patterns with FAIM: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAIM Gene

Orthologs for FAIM Gene

This gene was present in the common ancestor of animals.

Orthologs for FAIM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAIM 35
  • 92.33 (n)
  • 92.5 (a)
FAIM 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAIM 35
  • 91.96 (n)
  • 93.97 (a)
FAIM 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faim 35
  • 85.41 (n)
  • 90.55 (a)
Faim 16
Faim 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAIM 35
  • 99.67 (n)
  • 99.5 (a)
FAIM 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362113 35
  • 85.07 (n)
  • 90.55 (a)
oppossum
(Monodelphis domestica)
Mammalia FAIM 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAIM 35
  • 81.06 (n)
  • 86.93 (a)
FAIM 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAIM 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faim 35
  • 73.48 (n)
  • 86.36 (a)
Str.17723 35
zebrafish
(Danio rerio)
Actinopterygii faima 35
  • 72.22 (n)
  • 77.01 (a)
faima 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4866 35
fruit fly
(Drosophila melanogaster)
Insecta CG10257 37
  • 37 (a)
CG10257 35
  • 47.54 (n)
  • 36.84 (a)
CG10257 36
  • 31 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011987 35
  • 49.41 (n)
  • 41.76 (a)
worm
(Caenorhabditis elegans)
Secernentea C44B11.1 37
  • 48 (a)
C44B11.1 35
  • 57.31 (n)
  • 52.63 (a)
C44B11.1 36
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4726 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for FAIM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAIM Gene

ENSEMBL:
Gene Tree for FAIM (if available)
TreeFam:
Gene Tree for FAIM (if available)

Paralogs for FAIM Gene

No data available for Paralogs for FAIM Gene

Variants for FAIM Gene

Sequence variations from dbSNP and Humsavar for FAIM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs641320 - 138,629,115(-) CATAG(C/T)ATCTT reference, missense
rs13043 - 138,629,146(-) TCTCC(A/G)ATTTT reference, missense
rs361073 -- 138,628,322(-) ACGGG(A/G)TTTAT intron-variant
rs361074 -- 138,627,987(-) TATTA(C/T)AGTGA intron-variant
rs361075 -- 138,626,276(-) TCAAA(A/G)TGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAIM Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914

Variation tolerance for FAIM Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.70; 94.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAIM Gene

Disorders for FAIM Gene

Relevant External Links for FAIM

Genetic Association Database (GAD)
FAIM
Human Genome Epidemiology (HuGE) Navigator
FAIM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAIM

No disorders were found for FAIM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAIM Gene

Publications for FAIM Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. (PMID: 10075978) Schneider T.J. … Rothstein T.L. (J. Exp. Med. 1999) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma. (PMID: 23138182) Huo J. … Lam K.P. (Leukemia 2013) 3
  5. FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis. (PMID: 24305822) Moubarak R.S. … Comella J.X. (J. Neurosci. 2013) 3

Products for FAIM Gene

Sources for FAIM Gene

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