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Aliases for FAIM Gene

Aliases for FAIM Gene

  • Fas Apoptotic Inhibitory Molecule 2 3
  • FAIM1 3 4
  • Fas Apoptotic Inhibitory Molecule 1 3
  • FAIM2 6
  • NMP35 6
  • LFG 6

External Ids for FAIM Gene

Summaries for FAIM Gene

Entrez Gene Summary for FAIM Gene

  • The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FAIM Gene

FAIM (Fas Apoptotic Inhibitory Molecule) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and FAS (CD95) signaling pathway.

UniProtKB/Swiss-Prot for FAIM Gene

  • Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAIM Gene

Genomics for FAIM Gene

Genomic Location for FAIM Gene

Start:
138,608,606 bp from pter
End:
138,633,376 bp from pter
Size:
24,771 bases
Orientation:
Plus strand

Genomic View for FAIM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM Gene

Regulatory Elements for FAIM Gene

Proteins for FAIM Gene

  • Protein details for FAIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVQ4-FAIM1_HUMAN
    Recommended name:
    Fas apoptotic inhibitory molecule 1
    Protein Accession:
    Q9NVQ4
    Secondary Accessions:
    • Q6IAN2

    Protein attributes for FAIM Gene

    Size:
    179 amino acids
    Molecular mass:
    20215 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86174.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAIM Gene

    Alternative splice isoforms for FAIM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAIM Gene

Proteomics data for FAIM Gene at MOPED

Post-translational modifications for FAIM Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys47 and Lys160

No data available for DME Specific Peptides for FAIM Gene

Domains for FAIM Gene

Protein Domains for FAIM Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

FAIM1_HUMAN
Family:
  • Belongs to the FAIM1 family.:
    • Q9NVQ4
genes like me logo Genes that share domains with FAIM: view

No data available for Gene Families for FAIM Gene

Function for FAIM Gene

Molecular function for FAIM Gene

UniProtKB/Swiss-Prot Function: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

Gene Ontology (GO) - Molecular Function for FAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAIM: view
genes like me logo Genes that share phenotypes with FAIM: view

Animal Models for FAIM Gene

MGI Knock Outs for FAIM:

miRNA for FAIM Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FAIM Gene

Localization for FAIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAIM Gene COMPARTMENTS Subcellular localization image for FAIM gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FAIM: view

Pathways for FAIM Gene

genes like me logo Genes that share pathways with FAIM: view

Pathways by source for FAIM Gene

1 Cell Signaling Technology pathway for FAIM Gene

Interacting Proteins for FAIM Gene

Gene Ontology (GO) - Biological Process for FAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with FAIM: view

Transcripts for FAIM Gene

Unigene Clusters for FAIM Gene

Fas apoptotic inhibitory molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6:

Relevant External Links for FAIM Gene

GeneLoc Exon Structure for
FAIM
ECgene alternative splicing isoforms for
FAIM

Expression for FAIM Gene

mRNA expression in normal human tissues for FAIM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAIM Gene

SOURCE GeneReport for Unigene cluster for FAIM Gene Hs.173438

genes like me logo Genes that share expressions with FAIM: view

Orthologs for FAIM Gene

This gene was present in the common ancestor of animals.

Orthologs for FAIM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAIM 36
  • 99.67 (n)
  • 99.5 (a)
FAIM 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAIM 36
  • 92.33 (n)
  • 92.5 (a)
FAIM 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAIM 36
  • 91.96 (n)
  • 93.97 (a)
FAIM 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faim 36
  • 85.41 (n)
  • 90.55 (a)
Faim 16
Faim 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAIM 37
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362113 36
  • 85.07 (n)
  • 90.55 (a)
chicken
(Gallus gallus)
Aves FAIM 36
  • 81.06 (n)
  • 86.93 (a)
FAIM 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAIM 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faim 36
  • 73.48 (n)
  • 86.36 (a)
Str.17723 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4866 36
zebrafish
(Danio rerio)
Actinopterygii faima 36
  • 72.22 (n)
  • 77.01 (a)
faima 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011987 36
  • 49.41 (n)
  • 41.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10257 36
  • 47.54 (n)
  • 36.84 (a)
CG10257 37
  • 31 (a)
OneToOne
CG10257 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea C44B11.1 36
  • 57.31 (n)
  • 52.63 (a)
C44B11.1 37
  • 47 (a)
OneToOne
C44B11.1 38
  • 48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4726 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 64 (a)
OneToOne
Species with no ortholog for FAIM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAIM Gene

ENSEMBL:
Gene Tree for FAIM (if available)
TreeFam:
Gene Tree for FAIM (if available)

Paralogs for FAIM Gene

No data available for Paralogs for FAIM Gene

Variants for FAIM Gene

Sequence variations from dbSNP and Humsavar for FAIM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13043 - 138,629,146(-) TCTCC(A/G)ATTTT missense, reference
rs361073 -- 138,628,322(-) ACGGG(A/G)TTTAT intron-variant
rs361074 -- 138,627,987(-) TATTA(C/T)AGTGA intron-variant
rs361075 -- 138,626,276(-) TCAAA(A/G)TGGTA intron-variant
rs361076 -- 138,625,857(-) gtcag(C/G)tctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAIM Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914

Relevant External Links for FAIM Gene

HapMap Linkage Disequilibrium report
FAIM

Disorders for FAIM Gene

(1) University of Copenhagen DISEASES for FAIM Gene

Relevant External Links for FAIM

Genetic Association Database (GAD)
FAIM
Human Genome Epidemiology (HuGE) Navigator
FAIM
genes like me logo Genes that share disorders with FAIM: view

No data available for UniProtKB/Swiss-Prot for FAIM Gene

Publications for FAIM Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. (PMID: 10075978) Schneider T.J. … Rothstein T.L. (J. Exp. Med. 1999) 2 3
  5. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G. … Peterson K. (Mol. Vis. 2002) 3 4

Products for FAIM Gene

Sources for FAIM Gene

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