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Aliases for FAIM Gene

Aliases for FAIM Gene

  • Fas Apoptotic Inhibitory Molecule 2 3 5
  • FAIM1 3 4
  • Fas Apoptotic Inhibitory Molecule 1 3

External Ids for FAIM Gene

Previous GeneCards Identifiers for FAIM Gene

  • GC03P135281
  • GC03P139129
  • GC03P139609
  • GC03P139648
  • GC03P139810
  • GC03P138327
  • GC03P135702

Summaries for FAIM Gene

Entrez Gene Summary for FAIM Gene

  • The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FAIM Gene

FAIM (Fas Apoptotic Inhibitory Molecule) is a Protein Coding gene. Among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Apoptosis and Autophagy.

UniProtKB/Swiss-Prot for FAIM Gene

  • Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

Additional gene information for FAIM Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAIM Gene

Genomics for FAIM Gene

Regulatory Elements for FAIM Gene

Enhancers for FAIM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H138578 1.1 Ensembl ENCODE dbSUPER 27.8 -30.4 -30350 0 ZNF217 IKZF1 BMI1 DPF2 IKZF2 RELA SPI1 FAIM CEP70 GC03M138521
GH03H138685 1.3 Ensembl ENCODE 22 +78.3 78320 2 PKNOX1 FOXA2 ATF1 ARID4B FEZF1 ZNF2 TCF12 SLC30A9 ATF7 RUNX3 FAIM CEP70 PIK3CB GC03P138644 GAPDHP39
GH03H138593 1.3 ENCODE dbSUPER 17.5 -14.3 -14332 2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 FAIM CEP70 RBP1 GC03M138521
GH03H138780 1 Ensembl ENCODE dbSUPER 19.1 +172.5 172537 0 GATA3 IRF2 GLIS1 FEZF1 FAIM CEP70 GAPDHP39 RPL23AP40
GH03H138914 1.7 FANTOM5 Ensembl ENCODE 11.2 +307.3 307262 2 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 CEP70 PIK3CB FAIM LINC01391 FOXL2NB FOXL2 ATP5G1P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAIM on UCSC Golden Path with GeneCards custom track

Promoters for FAIM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159038 506 1401 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF121 GLIS2 RUNX3 ZHX2 ZNF592

Genomic Location for FAIM Gene

Chromosome:
3
Start:
138,608,594 bp from pter
End:
138,633,376 bp from pter
Size:
24,783 bases
Orientation:
Plus strand

Genomic View for FAIM Gene

Genes around FAIM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAIM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM Gene

Proteins for FAIM Gene

  • Protein details for FAIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVQ4-FAIM1_HUMAN
    Recommended name:
    Fas apoptotic inhibitory molecule 1
    Protein Accession:
    Q9NVQ4
    Secondary Accessions:
    • Q6IAN2

    Protein attributes for FAIM Gene

    Size:
    179 amino acids
    Molecular mass:
    20215 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86174.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAIM Gene

    Alternative splice isoforms for FAIM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAIM Gene

Post-translational modifications for FAIM Gene

  • Ubiquitination at posLast=4747 and posLast=160160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAIM Gene

Domains & Families for FAIM Gene

Gene Families for FAIM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAIM Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAIM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVQ4

UniProtKB/Swiss-Prot:

FAIM1_HUMAN :
  • Belongs to the FAIM1 family.
Family:
  • Belongs to the FAIM1 family.
genes like me logo Genes that share domains with FAIM: view

Function for FAIM Gene

Molecular function for FAIM Gene

UniProtKB/Swiss-Prot Function:
Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

Phenotypes From GWAS Catalog for FAIM Gene

Gene Ontology (GO) - Molecular Function for FAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAIM: view
genes like me logo Genes that share phenotypes with FAIM: view

Animal Models for FAIM Gene

MGI Knock Outs for FAIM:

Animal Model Products

CRISPR Products

miRNA for FAIM Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FAIM
  • Applied Biological Materials Clones for FAIM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAIM Gene

Localization for FAIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAIM gene
Compartment Confidence
cytosol 4
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FAIM: view

Pathways & Interactions for FAIM Gene

genes like me logo Genes that share pathways with FAIM: view

Pathways by source for FAIM Gene

1 Cell Signaling Technology pathway for FAIM Gene
1 BioSystems pathway for FAIM Gene

Interacting Proteins for FAIM Gene

Gene Ontology (GO) - Biological Process for FAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with FAIM: view

No data available for SIGNOR curated interactions for FAIM Gene

Drugs & Compounds for FAIM Gene

No Compound Related Data Available

Transcripts for FAIM Gene

Unigene Clusters for FAIM Gene

Fas apoptotic inhibitory molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FAIM
  • Applied Biological Materials Clones for FAIM
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6:

Relevant External Links for FAIM Gene

GeneLoc Exon Structure for
FAIM
ECgene alternative splicing isoforms for
FAIM

Expression for FAIM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAIM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAIM Gene

This gene is overexpressed in Retina (32.1), Fetal ovary (9.0), and Spinal cord (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAIM Gene



NURSA nuclear receptor signaling pathways regulating expression of FAIM Gene:

FAIM

SOURCE GeneReport for Unigene cluster for FAIM Gene:

Hs.173438

Evidence on tissue expression from TISSUES for FAIM Gene

  • Nervous system(4.8)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with FAIM: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAIM Gene

Orthologs for FAIM Gene

This gene was present in the common ancestor of animals.

Orthologs for FAIM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAIM 33 34
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia FAIM 33 34
  • 92.33 (n)
dog
(Canis familiaris)
Mammalia FAIM 33 34
  • 91.96 (n)
mouse
(Mus musculus)
Mammalia Faim 33 16 34
  • 85.41 (n)
rat
(Rattus norvegicus)
Mammalia LOC100362113 33
  • 85.07 (n)
oppossum
(Monodelphis domestica)
Mammalia FAIM 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAIM 33 34
  • 81.06 (n)
lizard
(Anolis carolinensis)
Reptilia FAIM 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faim 33
  • 73.48 (n)
Str.17723 33
zebrafish
(Danio rerio)
Actinopterygii faima 33 34
  • 72.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4866 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011987 33
  • 49.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10257 35 33 34
  • 47.54 (n)
worm
(Caenorhabditis elegans)
Secernentea C44B11.1 35 33 34
  • 57.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 64 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4726 33
Species where no ortholog for FAIM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAIM Gene

ENSEMBL:
Gene Tree for FAIM (if available)
TreeFam:
Gene Tree for FAIM (if available)

Paralogs for FAIM Gene

No data available for Paralogs for FAIM Gene

Variants for FAIM Gene

Sequence variations from dbSNP and Humsavar for FAIM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000257199 -- 138,625,545(+) TATCT(A/G)GAGTC intron-variant
rs1000271818 -- 138,609,826(+) GTGAT(C/G)ATTTC intron-variant
rs1000411654 -- 138,617,292(+) ACTTG(A/T)ATAGC intron-variant
rs1000451690 -- 138,624,189(+) AGGAT(C/T)ATGAT intron-variant
rs1000586804 -- 138,623,866(+) AGGGT(A/G)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAIM Gene

Variant ID Type Subtype PubMed ID
dgv4908n100 CNV gain 25217958
esv3597916 CNV gain 21293372
nsv1110949 OTHER inversion 24896259
nsv428422 CNV gain+loss 18775914
nsv591854 CNV gain 21841781
nsv999041 CNV gain 25217958

Variation tolerance for FAIM Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.70; 94.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAIM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAIM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAIM Gene

Disorders for FAIM Gene

Relevant External Links for FAIM

Genetic Association Database (GAD)
FAIM
Human Genome Epidemiology (HuGE) Navigator
FAIM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAIM

No disorders were found for FAIM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAIM Gene

Publications for FAIM Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G … Peterson K (Molecular vision 2002) 3 4 60
  5. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. (PMID: 10075978) Schneider TJ … Rothstein TL (The Journal of experimental medicine 1999) 2 3 60

Products for FAIM Gene

  • Addgene plasmids for FAIM

Sources for FAIM Gene

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