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Aliases for FAHD2B Gene

Aliases for FAHD2B Gene

  • Fumarylacetoacetate Hydrolase Domain Containing 2B 2 3
  • EC 3.-.-.- 4

External Ids for FAHD2B Gene

Previous GeneCards Identifiers for FAHD2B Gene

  • GC02M097748
  • GC02M091709

Summaries for FAHD2B Gene

GeneCards Summary for FAHD2B Gene

FAHD2B (Fumarylacetoacetate Hydrolase Domain Containing 2B) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is FAHD1.

UniProtKB/Swiss-Prot for FAHD2B Gene

  • May have hydrolase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAHD2B Gene

Genomics for FAHD2B Gene

Regulatory Elements for FAHD2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAHD2B Gene

Start:
97,083,583 bp from pter
End:
97,094,882 bp from pter
Size:
11,300 bases
Orientation:
Minus strand

Genomic View for FAHD2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAHD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAHD2B Gene

Proteins for FAHD2B Gene

  • Protein details for FAHD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2I3-FAH2B_HUMAN
    Recommended name:
    Fumarylacetoacetate hydrolase domain-containing protein 2B
    Protein Accession:
    Q6P2I3
    Secondary Accessions:
    • D3DXH7
    • Q8NDK1

    Protein attributes for FAHD2B Gene

    Size:
    314 amino acids
    Molecular mass:
    34613 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for FAHD2B Gene

Proteomics data for FAHD2B Gene at MOPED

Post-translational modifications for FAHD2B Gene

  • Ubiquitination at Lys203 and Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for FAHD2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAHD2B Gene

Domains for FAHD2B Gene

Protein Domains for FAHD2B Gene

Suggested Antigen Peptide Sequences for FAHD2B Gene

Graphical View of Domain Structure for InterPro Entry

Q6P2I3

UniProtKB/Swiss-Prot:

FAH2B_HUMAN :
  • Q6P2I3
Family:
  • Belongs to the FAH family.
genes like me logo Genes that share domains with FAHD2B: view

No data available for Gene Families for FAHD2B Gene

Function for FAHD2B Gene

Molecular function for FAHD2B Gene

UniProtKB/Swiss-Prot Function: May have hydrolase activity.

Enzyme Numbers (IUBMB) for FAHD2B Gene

Gene Ontology (GO) - Molecular Function for FAHD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAHD2B: view

Animal Model Products

CRISPR Products

miRNA for FAHD2B Gene

miRTarBase miRNAs that target FAHD2B

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAHD2B Gene

Localization for FAHD2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAHD2B Gene COMPARTMENTS Subcellular localization image for FAHD2B gene
Compartment Confidence
mitochondrion 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAHD2B Gene

Pathways for FAHD2B Gene

SuperPathways for FAHD2B Gene

No Data Available

Interacting Proteins for FAHD2B Gene

Gene Ontology (GO) - Biological Process for FAHD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with FAHD2B: view

No data available for Pathways by source for FAHD2B Gene

Compounds for FAHD2B Gene

(2) HMDB Compounds for FAHD2B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with FAHD2B: view

Transcripts for FAHD2B Gene

Unigene Clusters for FAHD2B Gene

Fumarylacetoacetate hydrolase domain containing 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAHD2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAHD2B Gene

No ASD Table

Relevant External Links for FAHD2B Gene

GeneLoc Exon Structure for
FAHD2B
ECgene alternative splicing isoforms for
FAHD2B

Expression for FAHD2B Gene

mRNA expression in normal human tissues for FAHD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAHD2B Gene

SOURCE GeneReport for Unigene cluster for FAHD2B Gene Hs.567723

genes like me logo Genes that share expressions with FAHD2B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAHD2B Gene

Orthologs for FAHD2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAHD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAHD2B 35
  • 99.15 (n)
  • 99.04 (a)
FAHD2B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fahd2a 35
  • 84.66 (n)
  • 85.62 (a)
Fahd2a 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fahd2a 35
  • 84.13 (n)
  • 83.39 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18832 35
zebrafish
(Danio rerio)
Actinopterygii fahd2a 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11251 36
  • 33 (a)
ManyToMany
CG6028 36
  • 44 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP41 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3072 36
  • 66 (a)
OneToMany
Species with no ortholog for FAHD2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAHD2B Gene

ENSEMBL:
Gene Tree for FAHD2B (if available)
TreeFam:
Gene Tree for FAHD2B (if available)

Paralogs for FAHD2B Gene

Paralogs for FAHD2B Gene

Selected SIMAP similar genes for FAHD2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAHD2B: view

Variants for FAHD2B Gene

Sequence variations from dbSNP and Humsavar for FAHD2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1128346 -- 97,085,850(-) GATGC(C/T)ATGGC reference, synonymous-codon, intron-variant
rs1257084 -- 97,091,772(-) TATCA(A/G)GGATG intron-variant
rs1257088 -- 97,088,767(-) ATCCA(A/G)TTGCC intron-variant
rs1257089 -- 97,087,848(-) cattt(C/T)cattt intron-variant
rs1257090 -- 97,087,200(-) gtggc(A/G)ggtgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAHD2B Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
essv10696 CNV CNV 17122850
esv718 CNV CNV 17122850
dgv1229e1 CNV Complex 17122850
nsv834308 CNV Gain 17160897
essv17393 CNV CNV 17122850
nsv470477 CNV Loss 18288195
nsv874683 CNV Loss 21882294
nsv874684 CNV Gain 21882294
dgv4250n71 CNV Loss 21882294
nsv874687 CNV Loss 21882294

Relevant External Links for FAHD2B Gene

HapMap Linkage Disequilibrium report
FAHD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAHD2B Gene

Disorders for FAHD2B Gene

No disorders were found for FAHD2B Gene.

No data available for UniProtKB/Swiss-Prot for FAHD2B Gene

Publications for FAHD2B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PMID: 21987572) Lee K.A. … Doedens J.R. (J. Biol. Chem. 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for FAHD2B Gene

Sources for FAHD2B Gene

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