FAHD2B Gene
protein-coding GIFtS: 41
GCID: GC02M097748
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|
fumarylacetoacetate hydrolase domain containing 2B
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Aliases
for FAHD2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fumarylacetoacetate Hydrolase Domain Containing 2B1 2 | | DKFZp434N0621 | | Fumarylacetoacetate Hydrolase Domain-Containing Protein 2B2 | | EC 3.-.-.-3 |
Export aliases for FAHD2B gene to outside databasesPrevious GC identifers: GC02M097114 GC02M091709 |
Summaries
for FAHD2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FAH2B_HUMAN, Q6P2I3Function: May have hydrolase activity (By similarity)
|
Genomic Views
for FAHD2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAHD2B gene promoter:
AhR Bach1 Pax-5 NCX/Ncx Nkx2-5 XBP-1 C/EBPalpha Arnt HEN1 Max
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAHD2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAHD2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2FAHD2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M097748: view genomic region
(about GC identifiers)
Start:
|
97,747,779 bp from pter |
End:
|
97,760,619 bp from pter |
Size:
|
12,841 bases |
Orientation:
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minus strand |
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Proteins
for FAHD2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FAH2B_HUMAN, Q6P2I3 (See
protein sequence)Recommended Name: Fumarylacetoacetate hydrolase domain-containing protein 2B Size: 314 amino acids; 34613 Da
Cofactor: Calcium (Probable)
Cofactor: Magnesium (Probable)
Secondary accessions: D3DXH7 Q8NDK1Explore the universe of human proteins at neXtProt for FAHD2B: NX_Q6P2I3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P2I3
FAHD2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_955368.1
ENSEMBL proteins: ENSP00000410470 ENSP00000272610 ENSP00000444599
Human Recombinant Protein Products:
FAHD2B Antibody Products:
Assay Products for FAHD2B: |
Protein
Domains /
Families
for FAHD2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAHD2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P2I3ProtoNet protein and cluster: Q6P2I3 1 Blocks protein family: IPB002529 Fumarylacetoacetate (FAA) hydrolase
UniProtKB/Swiss-Prot: FAH2B_HUMAN, Q6P2I3Similarity: Belongs to the FAH family |
Function
for FAHD2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FAH2B_HUMAN, Q6P2I3Function: May have hydrolase activity (By similarity)Enzyme Number (IUBMB): EC 3.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAHD2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAHD2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAHD2B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
FAHD2B for ontologies About GeneDecksing
|
Pathways & Interactions
for FAHD2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAHD2B
|
Drugs & Compounds
for FAHD2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAHD2B
2 HMDB Compounds for FAHD2B About this table
Search CenterWatch for drugs/clinical trials and news about FAHD2B / FAH2B
|
Transcripts
for FAHD2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAHD2B gene: NM_199336.1 Unigene Cluster for FAHD2B: Fumarylacetoacetate hydrolase domain containing 2B Hs.567723 [show with all ESTs]Unigene Representative Sequence: BC06451111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443258 ENST00000467292 ENST00000467092 ENST00000483000 ENST00000414820
ENST00000272610(uc002sxm.3) ENST00000474849 ENST00000463096 ENST00000468548
ENST00000483657 ENST00000440566
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAHD2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAHD2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAHD2B (NM_199336) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAHD2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAHD2B |
Additional cDNA sequence: AK295056.1 AL833869.1 BC064511.1 6 DOTS entries: DT.102830083 DT.95153101 DT.450507 DT.92470091 DT.120944841 DT.97847407 24/57 AceView cDNA sequences (see all 57): AL833869 BG680706 BX282424 BC064511 BM663019 CD678752 AI458002 BM801603 NM_199336 BI756332 AA811294 BU679698 BM906221 BX282113 BQ017817 BE275625 BI819369 BI829546 BI547630 BI752152 BG700302 BI259537 BU856372 BQ921365
GeneLoc Exon Structure
|
Expression
for FAHD2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAHD2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FAHD2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAHD2B
SOURCE GeneReport for Unigene cluster: Hs.567723
SABiosciences Custom PCR Arrays for FAHD2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAHD2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAHD2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAHD2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAHD2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAHD2B |
Orthologs
for FAHD2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAHD2B gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAHD2A6 |
-- |
70(a) |
1 → many |
Un(45056115-45057501) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.188322 |
Transcribed sequence with weak similarity to protein more |
77.86(n) |
|
CF378324.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fahd2a6 |
fumarylacetoacetate hydrolase domain containing 2A... |
64(a) |
1 → many |
8(43206073-43275912) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG60286CG112516 |
-- |
44(a)29(a) |
many ↔ manymany ↔ many |
3R(17849981-17851226) 3L(13081681-13083069) |
ENSEMBL Gene Tree for FAHD2B (if available)
TreeFam Gene Tree for FAHD2B (if available) |
Paralogs
for FAHD2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAHD2B gene
- FAHD12 FAHD2A2
2 SIMAP similar genes for FAHD2B using alignment to 1 protein entry: FAH2B_HUMAN:FAHD2A FAHD1
FAHD2B for paralogs About GeneDecksing
|
Genomic Variants
for FAHD2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAHD2B (97747779 - 97760619 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FAHD2B
4 CNVs: 3378 30101 89828 2402 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAHD2B |
|
Disorders
/ Diseases
for FAHD2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAHD2B for disorders About GeneDecksing
2  diseases for FAHD2B: About MalaCardstuberculosis mycobacterium tuberculosis
Export disorders for FAHD2B gene to outside databases
|
Publications
for FAHD2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAHD2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAHD2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FAHD2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAHD2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAHD2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAHD2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAHD2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAHD2B gene:
Search GeneIP for patents involving FAHD2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAHD2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAHD2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAHD2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAHD2B | | | OriGene Protein Over-expression Lysate for FAHD2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAHD2B | | OriGene 3'-UTR Clone for FAHD2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAHD2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAHD2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |  |  |  | |
| | | | Search Tocris compounds for FAHD2B |
| |  |  |  |  | | | | |
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 |
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 | | | FAHD2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAHD2B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAHD2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAHD2B |
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