Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAHD2A Gene

Aliases for FAHD2A Gene

  • Fumarylacetoacetate Hydrolase Domain Containing 2A 2 3
  • Fumarylacetoacetate Hydrolase Domain-Containing Protein 2A 3
  • Fumarylacetoacetate Hydrolase Domain Containing 1 3
  • EC 3.-.-.- 4
  • CGI-105 3

External Ids for FAHD2A Gene

Summaries for FAHD2A Gene

GeneCards Summary for FAHD2A Gene

FAHD2A (Fumarylacetoacetate Hydrolase Domain Containing 2A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is FAHD1.

UniProtKB/Swiss-Prot for FAHD2A Gene

  • May have hydrolase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAHD2A Gene

Genomics for FAHD2A Gene

Genomic Location for FAHD2A Gene

Start:
95,402,691 bp from pter
End:
95,416,616 bp from pter
Size:
13,926 bases
Orientation:
Plus strand

Genomic View for FAHD2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAHD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAHD2A Gene

Regulatory Elements for FAHD2A Gene

Proteins for FAHD2A Gene

  • Protein details for FAHD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GK7-FAH2A_HUMAN
    Recommended name:
    Fumarylacetoacetate hydrolase domain-containing protein 2A
    Protein Accession:
    Q96GK7
    Secondary Accessions:
    • Q9Y3B0

    Protein attributes for FAHD2A Gene

    Size:
    314 amino acids
    Molecular mass:
    34596 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for FAHD2A Gene

Proteomics data for FAHD2A Gene at MOPED

Post-translational modifications for FAHD2A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys203 and Lys224

Other Protein References for FAHD2A Gene

No data available for DME Specific Peptides for FAHD2A Gene

Domains for FAHD2A Gene

Protein Domains for FAHD2A Gene

UniProtKB/Swiss-Prot:

FAH2A_HUMAN
Family:
  • Belongs to the FAH family.:
    • Q96GK7
genes like me logo Genes that share domains with FAHD2A: view

No data available for Gene Families for FAHD2A Gene

Function for FAHD2A Gene

Molecular function for FAHD2A Gene

UniProtKB/Swiss-Prot Function: May have hydrolase activity.

Enzyme Numbers (IUBMB) for FAHD2A Gene

Gene Ontology (GO) - Molecular Function for FAHD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAHD2A: view

Phenotypes for FAHD2A Gene

genes like me logo Genes that share phenotypes with FAHD2A: view

miRNA for FAHD2A Gene

miRTarBase miRNAs that target FAHD2A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FAHD2A Gene

Localization for FAHD2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAHD2A Gene COMPARTMENTS Subcellular localization image for FAHD2A gene
Compartment Confidence
mitochondrion 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for FAHD2A Gene

Pathways for FAHD2A Gene

SuperPathways for FAHD2A Gene

No Data Available

Interacting Proteins for FAHD2A Gene

Gene Ontology (GO) - Biological Process for FAHD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with FAHD2A: view

No data available for Pathways by source for FAHD2A Gene

Compounds for FAHD2A Gene

(2) HMDB Compounds for FAHD2A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with FAHD2A: view

Transcripts for FAHD2A Gene

Unigene Clusters for FAHD2A Gene

Fumarylacetoacetate hydrolase domain containing 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAHD2A Gene

No ASD Table

Relevant External Links for FAHD2A Gene

GeneLoc Exon Structure for
FAHD2A
ECgene alternative splicing isoforms for
FAHD2A

Expression for FAHD2A Gene

mRNA expression in normal human tissues for FAHD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAHD2A Gene

SOURCE GeneReport for Unigene cluster for FAHD2A Gene Hs.531247

genes like me logo Genes that share expressions with FAHD2A: view

Orthologs for FAHD2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAHD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAHD2A 36
  • 99.58 (n)
  • 99.04 (a)
FAHD2A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 90 (a)
OneToMany
FAHD2A 36
  • 87.15 (n)
  • 89.81 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 93 (a)
OneToMany
FAHD2A 36
  • 89.99 (n)
  • 94.25 (a)
mouse
(Mus musculus)
Mammalia Fahd2a 16
Fahd2a 37
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 69 (a)
OneToMany
FAHD2A 36
  • 65.87 (n)
  • 65.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6320 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fahd2a 36
  • 67.46 (n)
  • 69.39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.289 36
zebrafish
(Danio rerio)
Actinopterygii Dr.21429 36
fahd2a 36
  • 65.5 (n)
  • 68.18 (a)
fahd2a 37
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011634 36
  • 55.56 (n)
  • 51.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11251 37
  • 33 (a)
ManyToMany
CG6028 36
  • 52.91 (n)
  • 45.1 (a)
CG6028 37
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP41 37
  • 28 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07506 36
  • 52.24 (n)
  • 42.04 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6150 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3072 37
  • 66 (a)
OneToMany
Species with no ortholog for FAHD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAHD2A Gene

ENSEMBL:
Gene Tree for FAHD2A (if available)
TreeFam:
Gene Tree for FAHD2A (if available)

Paralogs for FAHD2A Gene

Paralogs for FAHD2A Gene

Selected SIMAP similar genes for FAHD2A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAHD2A Gene

genes like me logo Genes that share paralogs with FAHD2A: view

Variants for FAHD2A Gene

Sequence variations from dbSNP and Humsavar for FAHD2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1045310 -- 95,402,821(+) CCTTC(C/G)GCCCC utr-variant-5-prime
rs1045311 -- 95,402,833(+) CGAGC(C/T)CTAAC utr-variant-5-prime
rs1045330 -- 95,410,931(+) CTGGC(A/T)AATGA reference, missense
rs1045332 - 95,410,934(+) GCAAA(C/T)GAGAC missense, reference
rs1045333 -- 95,410,935(+) CAAAT(A/G)AGACG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FAHD2A Gene

Variant ID Type Subtype PubMed ID
dgv1228e1 CNV Complex 17122850
nsv7320 OTHER Inversion 18451855

Relevant External Links for FAHD2A Gene

HapMap Linkage Disequilibrium report
FAHD2A

Disorders for FAHD2A Gene

Relevant External Links for FAHD2A

Genetic Association Database (GAD)
FAHD2A
Human Genome Epidemiology (HuGE) Navigator
FAHD2A
genes like me logo Genes that share disorders with FAHD2A: view

No data available for UniProtKB/Swiss-Prot for FAHD2A Gene

Publications for FAHD2A Gene

  1. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 49
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880. (PMID: 15551868) Manjasetty B.A. … Heinemann U. (Biol. Chem. 2004) 3

Products for FAHD2A Gene

Sources for FAHD2A Gene

Back to Top

Content