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Aliases for FAHD2A Gene

Aliases for FAHD2A Gene

  • Fumarylacetoacetate Hydrolase Domain Containing 2A 2 3 5
  • Fumarylacetoacetate Hydrolase Domain Containing 1 3
  • EC 3.-.-.- 4
  • CGI-105 3

External Ids for FAHD2A Gene

Previous GeneCards Identifiers for FAHD2A Gene

  • GC02P095490
  • GC02P096068
  • GC02P090095

Summaries for FAHD2A Gene

GeneCards Summary for FAHD2A Gene

FAHD2A (Fumarylacetoacetate Hydrolase Domain Containing 2A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is FAHD1.

UniProtKB/Swiss-Prot for FAHD2A Gene

  • May have hydrolase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAHD2A Gene

Genomics for FAHD2A Gene

Regulatory Elements for FAHD2A Gene

Promoters for FAHD2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAHD2A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAHD2A Gene

Chromosome:
2
Start:
95,402,691 bp from pter
End:
95,416,616 bp from pter
Size:
13,926 bases
Orientation:
Plus strand

Genomic View for FAHD2A Gene

Genes around FAHD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAHD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAHD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAHD2A Gene

Proteins for FAHD2A Gene

  • Protein details for FAHD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GK7-FAH2A_HUMAN
    Recommended name:
    Fumarylacetoacetate hydrolase domain-containing protein 2A
    Protein Accession:
    Q96GK7
    Secondary Accessions:
    • Q9Y3B0

    Protein attributes for FAHD2A Gene

    Size:
    314 amino acids
    Molecular mass:
    34596 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for FAHD2A Gene

Proteomics data for FAHD2A Gene at MOPED

Post-translational modifications for FAHD2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAHD2A Gene

Antibody Products

No data available for DME Specific Peptides for FAHD2A Gene

Domains & Families for FAHD2A Gene

Protein Domains for FAHD2A Gene

Suggested Antigen Peptide Sequences for FAHD2A Gene

Graphical View of Domain Structure for InterPro Entry

Q96GK7

UniProtKB/Swiss-Prot:

FAH2A_HUMAN :
  • Belongs to the FAH family.
Family:
  • Belongs to the FAH family.
genes like me logo Genes that share domains with FAHD2A: view

No data available for Gene Families for FAHD2A Gene

Function for FAHD2A Gene

Molecular function for FAHD2A Gene

UniProtKB/Swiss-Prot Function:
May have hydrolase activity.

Enzyme Numbers (IUBMB) for FAHD2A Gene

Gene Ontology (GO) - Molecular Function for FAHD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with FAHD2A: view
genes like me logo Genes that share phenotypes with FAHD2A: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAHD2A Gene

Localization for FAHD2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAHD2A Gene COMPARTMENTS Subcellular localization image for FAHD2A gene
Compartment Confidence
mitochondrion 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAHD2A Gene

Pathways & Interactions for FAHD2A Gene

SuperPathways for FAHD2A Gene

No Data Available

Interacting Proteins for FAHD2A Gene

Gene Ontology (GO) - Biological Process for FAHD2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAHD2A Gene

Drugs & Compounds for FAHD2A Gene

(2) Drugs for FAHD2A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with FAHD2A: view

Transcripts for FAHD2A Gene

Unigene Clusters for FAHD2A Gene

Fumarylacetoacetate hydrolase domain containing 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAHD2A Gene

No ASD Table

Relevant External Links for FAHD2A Gene

GeneLoc Exon Structure for
FAHD2A
ECgene alternative splicing isoforms for
FAHD2A

Expression for FAHD2A Gene

mRNA expression in normal human tissues for FAHD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAHD2A Gene

This gene is overexpressed in Salivary gland (19.9) and Liver (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAHD2A Gene



SOURCE GeneReport for Unigene cluster for FAHD2A Gene Hs.531247

genes like me logo Genes that share expression patterns with FAHD2A: view

Protein tissue co-expression partners for FAHD2A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAHD2A Gene

Orthologs for FAHD2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAHD2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAHD2A 35
  • 87.15 (n)
  • 89.81 (a)
-- 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FAHD2A 35
  • 89.99 (n)
  • 94.25 (a)
-- 36
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FAHD2A 35
  • 99.58 (n)
  • 99.04 (a)
FAHD2A 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fahd2a 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAHD2A 35
  • 65.87 (n)
  • 65.75 (a)
-- 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fahd2a 35
  • 67.46 (n)
  • 69.39 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6320 35
zebrafish
(Danio rerio)
Actinopterygii Dr.21429 35
fahd2a 35
  • 65.5 (n)
  • 68.18 (a)
fahd2a 36
  • 63 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.289 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011634 35
  • 55.56 (n)
  • 51.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6028 35
  • 52.91 (n)
  • 45.1 (a)
CG11251 36
  • 33 (a)
ManyToMany
CG6028 36
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP41 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6150 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07506 35
  • 52.24 (n)
  • 42.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3072 36
  • 66 (a)
OneToMany
Species with no ortholog for FAHD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAHD2A Gene

ENSEMBL:
Gene Tree for FAHD2A (if available)
TreeFam:
Gene Tree for FAHD2A (if available)

Paralogs for FAHD2A Gene

Paralogs for FAHD2A Gene

(2) SIMAP similar genes for FAHD2A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for FAHD2A Gene

genes like me logo Genes that share paralogs with FAHD2A: view

Variants for FAHD2A Gene

Sequence variations from dbSNP and Humsavar for FAHD2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1045332 - 95,410,934(+) GCAAA(C/T)GAGAC intron-variant, reference, missense
rs1062911 -- 95,402,807(+) CCCGC(C/T)GCCCT upstream-variant-2KB, utr-variant-5-prime
rs1045310 -- 95,402,821(+) CCTTC(C/G)GCCCC upstream-variant-2KB, utr-variant-5-prime
rs1045311 -- 95,402,833(+) CGAGC(C/T)CTAAC upstream-variant-2KB, utr-variant-5-prime
rs1045330 -- 95,410,931(+) CTGGC(A/T)AATGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAHD2A Gene

Variant ID Type Subtype PubMed ID
dgv1228e1 CNV Complex 17122850
nsv7320 OTHER Inversion 18451855

Variation tolerance for FAHD2A Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAHD2A Gene

HapMap Linkage Disequilibrium report
FAHD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAHD2A Gene

Disorders for FAHD2A Gene

Relevant External Links for FAHD2A

Genetic Association Database (GAD)
FAHD2A
Human Genome Epidemiology (HuGE) Navigator
FAHD2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAHD2A

No disorders were found for FAHD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAHD2A Gene

Publications for FAHD2A Gene

  1. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAHD2A Gene

Sources for FAHD2A Gene

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