Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAHD2A Gene

Aliases for FAHD2A Gene

  • Fumarylacetoacetate Hydrolase Domain Containing 2A 2 3 5
  • Fumarylacetoacetate Hydrolase Domain-Containing Protein 2A 3
  • Fumarylacetoacetate Hydrolase Domain Containing 1 3
  • EC 3.-.-.- 4
  • CGI-105 3

External Ids for FAHD2A Gene

Previous GeneCards Identifiers for FAHD2A Gene

  • GC02P095490
  • GC02P096068
  • GC02P090095

Summaries for FAHD2A Gene

GeneCards Summary for FAHD2A Gene

FAHD2A (Fumarylacetoacetate Hydrolase Domain Containing 2A) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is FAHD2B.

UniProtKB/Swiss-Prot for FAHD2A Gene

  • May have hydrolase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAHD2A Gene

Genomics for FAHD2A Gene

Regulatory Elements for FAHD2A Gene

Enhancers for FAHD2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F095729 0.7 ENCODE 11.4 +326.4 326397 0.2 CTCF ZNF654 CEBPB REST RAD21 YY1 ZSCAN16 GATAD1 SCRT2 CEBPA FAHD2A GC02M095699 LOC105373492
GH02F095401 1.1 ENCODE 0.8 0.0 -21 2.4 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SP3 SP5 NFYC MXD4 FAHD2A FABP7P2
GH02F095389 1.2 Ensembl ENCODE 0.4 -11.2 -11236 4.9 MLX ARID4B ZNF48 YY1 ZNF143 ZHX2 MXD4 REST PPARG KAT8 LOC101926959 ZNF514 CIAO1 FAHD2A FABP7P2
GH02F095384 1 Ensembl ENCODE 0.3 -17.3 -17303 2.3 KLF1 TFAP4 THRB RARA ZKSCAN1 HNF4G NR2F6 NFIA NR2F1 CEBPB ZNF514 FABP7P2 FAHD2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAHD2A on UCSC Golden Path with GeneCards custom track

Promoters for FAHD2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000676990 109 1601 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SP3 SP5 NFYC MXD4

Genomic Location for FAHD2A Gene

95,402,691 bp from pter
95,416,616 bp from pter
13,926 bases
Plus strand

Genomic View for FAHD2A Gene

Genes around FAHD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAHD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAHD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAHD2A Gene

Proteins for FAHD2A Gene

  • Protein details for FAHD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fumarylacetoacetate hydrolase domain-containing protein 2A
    Protein Accession:
    Secondary Accessions:
    • Q9Y3B0

    Protein attributes for FAHD2A Gene

    314 amino acids
    Molecular mass:
    34596 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for FAHD2A Gene

Post-translational modifications for FAHD2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAHD2A Gene

Domains & Families for FAHD2A Gene

Protein Domains for FAHD2A Gene

Suggested Antigen Peptide Sequences for FAHD2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAH family.
  • Belongs to the FAH family.
genes like me logo Genes that share domains with FAHD2A: view

No data available for Gene Families for FAHD2A Gene

Function for FAHD2A Gene

Molecular function for FAHD2A Gene

UniProtKB/Swiss-Prot Function:
May have hydrolase activity.

Enzyme Numbers (IUBMB) for FAHD2A Gene

Gene Ontology (GO) - Molecular Function for FAHD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAHD2A: view
genes like me logo Genes that share phenotypes with FAHD2A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAHD2A Gene

Localization for FAHD2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAHD2A gene
Compartment Confidence
mitochondrion 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAHD2A Gene

Pathways & Interactions for FAHD2A Gene

SuperPathways for FAHD2A Gene

No Data Available

Interacting Proteins for FAHD2A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)
Selected Interacting proteins: Q96GK7-FAH2A_HUMAN ENSP00000233379 for FAHD2A Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAHD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with FAHD2A: view

No data available for Pathways by source and SIGNOR curated interactions for FAHD2A Gene

Drugs & Compounds for FAHD2A Gene

(2) Drugs for FAHD2A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with FAHD2A: view

Transcripts for FAHD2A Gene

Unigene Clusters for FAHD2A Gene

Fumarylacetoacetate hydrolase domain containing 2A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAHD2A Gene

No ASD Table

Relevant External Links for FAHD2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAHD2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAHD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAHD2A Gene

This gene is overexpressed in Salivary gland (19.9) and Liver (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAHD2A Gene

Protein tissue co-expression partners for FAHD2A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAHD2A Gene:


SOURCE GeneReport for Unigene cluster for FAHD2A Gene:

genes like me logo Genes that share expression patterns with FAHD2A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAHD2A Gene

Orthologs for FAHD2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAHD2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAHD2A 34 35
  • 99.58 (n)
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
  • 89.99 (n)
(Bos Taurus)
Mammalia -- 35
  • 90 (a)
  • 87.15 (n)
(Mus musculus)
Mammalia Fahd2a 35
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
(Gallus gallus)
Aves -- 35
  • 69 (a)
  • 65.87 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fahd2a 34
  • 67.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6320 34
(Danio rerio)
Actinopterygii fahd2a 34 35
  • 65.5 (n)
Dr.21429 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.289 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011634 34
  • 55.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6028 34 35
  • 52.91 (n)
CG11251 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP41 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3072 35
  • 66 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07506 34
  • 52.24 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6150 34
Species where no ortholog for FAHD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAHD2A Gene

Gene Tree for FAHD2A (if available)
Gene Tree for FAHD2A (if available)

Paralogs for FAHD2A Gene

Paralogs for FAHD2A Gene

(2) SIMAP similar genes for FAHD2A Gene using alignment to 3 proteins: Pseudogenes for FAHD2A Gene

genes like me logo Genes that share paralogs with FAHD2A: view

Variants for FAHD2A Gene

Sequence variations from dbSNP and Humsavar for FAHD2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1045310 -- 95,402,821(+) CCTTC(C/G)GCCCC upstream-variant-2KB, utr-variant-5-prime
rs1045311 -- 95,402,833(+) CGAGC(C/T)CTAAC upstream-variant-2KB, utr-variant-5-prime
rs1045330 -- 95,410,931(+) CTGGC(A/T)AATGA intron-variant, reference, missense
rs1045332 -- 95,410,934(+) GCAAA(C/T)GAGAC intron-variant, reference, missense
rs1045333 -- 95,410,935(+) CAAAT(A/G)AGACG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAHD2A Gene

Variant ID Type Subtype PubMed ID
esv2759076 CNV loss 17122850
esv3591652 OTHER inversion 21293372
nsv1160825 CNV duplication 26073780
nsv7320 OTHER inversion 18451855
nsv961449 CNV duplication 23825009
nsv998014 CNV gain 25217958

Variation tolerance for FAHD2A Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAHD2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAHD2A Gene

Disorders for FAHD2A Gene

Relevant External Links for FAHD2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAHD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAHD2A Gene

Publications for FAHD2A Gene

  1. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 46 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for FAHD2A Gene

Sources for FAHD2A Gene

Loading form....