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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAF2 Gene

protein-coding   GIFtS: 50
GCID: GC05P175875

Fas Associated Factor Family Member 2

(Previous name: UBX domain containing 8)
(Previous symbol: UBXD8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fas Associated Factor Family Member 21 2     Expressed In T Cells And Eosinophils In Atopic Dermatitis1
UBXD81 2 3     Expressed In T-Cells And Eosinophils In Atopic Dermatitis2
UBX Domain Containing 81 2     FAS-Associated Factor 22
UBX Domain Protein 3B1 2     KIAA08873
ETEA2 3     Protein ETEA3
UBXN3B2 3     B17.2L5
UBX Domain-Containing Protein 3B2 3     MMTN5
UBX Domain-Containing Protein 82 3     NDUNDUFA12L5

External Ids:    HGNC: 246661   Entrez Gene: 231972   Ensembl: ENSG000001131947   OMIM: 6096535   UniProtKB: Q96CS33   

Export aliases for FAF2 gene to outside databases

Previous GC identifers: GC05P175809 GC05P170799


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAF2 Gene:
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD),
compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in
T cells and eosinophils of AD patients. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAF2 Gene: 
FAF2 (Fas associated factor family member 2) is a protein-coding gene. Diseases associated with FAF2 include atopic dermatitis, and dermatitis. GO annotations related to this gene include ubiquitin binding and ubiquitin protein ligase binding. An important paralog of this gene is FAF1.

UniProtKB/Swiss-Prot: FAF2_HUMAN, Q96CS3
Function: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum
lumen to the cytoplasm and their degradation by the proteasome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAF2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Tal-1   GATA-3   Nkx3-1 v1   E47   Nkx3-1 v2   MZF-1   Nkx3-1 v3   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

FAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAF2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175875:  view genomic region     (about GC identifiers)

Start:
175,874,629 bp from pter      End:
175,937,075 bp from pter
Size:
62,447 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAF2_HUMAN, Q96CS3 (See protein sequence)
Recommended Name: FAS-associated factor 2  
Size: 445 amino acids; 52623 Da
Subunit: Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1
Subcellular location: Cytoplasm. Lipid droplet. Endoplasmic reticulum
Miscellaneous: Up-regulated in T-cells and eosinophils from patients with atopic dermatitis
Caution: It seems odd to name this protein FAS-associated factor, but not have any mention of this in the CC lines
1 PDB 3D structure from and Proteopedia for FAF2:
2DAM (3D)    
Secondary accessions: O94963 Q8IUF2 Q9BRP2 Q9BVM7

Explore the universe of human proteins at neXtProt for FAF2: NX_Q96CS3

Explore proteomics data for FAF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CS3

  • FAF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAF2 Protein Expression
    REFSEQ proteins: NP_055428.1  
    ENSEMBL proteins: 
     ENSP00000424146   ENSP00000261942  

    Human Recombinant Protein Products for FAF2: 
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    OriGene Protein Over-expression Lysate for FAF2
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    Novus Biologicals FAF2 Protein
    Novus Biologicals FAF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAF2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005811lipid particle IDA14741744
    GO:0034098Cdc48p-Npl4p-Ufd1p AAA ATPase complex IDA18775313

    FAF2 for ontologies           About GeneDecksing



    FAF2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for FAF2 
    Cloud-Clone Corp. CLIAs for FAF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBXN: UBX domain containing

    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR006577 UAS
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry Q96CS3

    ProtoNet protein and cluster: Q96CS3

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB001012 UBX domain


    UniProtKB/Swiss-Prot: FAF2_HUMAN, Q96CS3
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 UBX domain


    FAF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAF2_HUMAN, Q96CS3
    Function: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum
    lumen to the cytoplasm and their degradation by the proteasome

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19818707
    GO:0031625ubiquitin protein ligase binding IDA18775313
    GO:0043130ubiquitin binding IDA18775313
         
    FAF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Faf2):
     no phenotypic analysis 

    FAF2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAF2 

    miRNA
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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate FAF2 (see all 77):
    hsa-miR-106a hsa-miR-146a hsa-miR-218-1* hsa-miR-30d hsa-miR-374a hsa-miR-519a hsa-miR-30a hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidFAF2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of FAF2

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for FAF2 (Q96CS33 ENSP000002619424) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=2 STRING: ENSP00000290649
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    CUL2Q136173, ENSP000003638804I2D: score=2 STRING: ENSP00000363880
    HUWE1Q7Z6Z73, ENSP000002628544I2D: score=2 STRING: ENSP00000262854
    LGALS3BPQ083803, ENSP000002627764I2D: score=2 STRING: ENSP00000262776
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein IEA--

    FAF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAF2

    Search CenterWatch for drugs/clinical trials and news about FAF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAF2 gene: 
    NM_014613.2  

    Unigene Cluster for FAF2:

    Fas associated factor family member 2
    Hs.484242  [show with all ESTs]
    Unigene Representative Sequence: NM_014613
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510730 ENST00000261942(uc003mej.4) ENST00000506061 ENST00000510446
    ENST00000504983 ENST00000513627
    miRNA
    Products:
         
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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate FAF2 (see all 77):
    hsa-miR-106a hsa-miR-146a hsa-miR-218-1* hsa-miR-30d hsa-miR-374a hsa-miR-519a hsa-miR-30a hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidFAF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAF2
    Clone
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    OriGene ORF clones in mouse, rat for FAF2
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    GenScript: all cDNA clones in your preferred vector: FAF2 (NM_014613)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAF2
    Sirion Biotech Customized lentivirus for stable overexpression of FAF2 
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    Primer
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    OriGene qPCR primer pairs and template standards for FAF2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAF2

    Additional mRNA sequence: 

    AB020694.1 AB088120.1 AK304346.1 BC001069.1 BC006145.1 BC014001.2 BC015791.1 

    7 DOTS entries:

    DT.449292  DT.95091731  DT.100672020  DT.100818981  DT.97769935  DT.100818980  DT.40127998 

    24/394 AceView cDNA sequences (see all 394):

    AW020765 AI472233 BM504760 CD106955 AI741417 T34295 BG231715 BU629702 
    AI692702 BQ549767 BM710056 AI262133 BU620754 AW135479 AI629011 AI031705 
    AU185220 BM683010 BC006145 BI711291 BM875515 BU742365 BM509129 BQ007834 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATAATTTA
    FAF2 Expression
    About this image


    See FAF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAF2

    SOURCE GeneReport for Unigene cluster: Hs.484242

    UniProtKB/Swiss-Prot: FAF2_HUMAN, Q96CS3
    Tissue specificity: Broadly expressed, with highest levels in brain

        SABiosciences Custom PCR Arrays for FAF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAF2 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faf21 , 5 Fas associated factor family member 21, 5 90.41(n)1
    97.75(a)1
      13 (28.88 cM)5
    765771  NM_178397.31  NP_848484.21 
     546217845 
    chicken
    (Gallus gallus)
    Aves FAF21 Fas associated factor family member 2 82.1(n)
    94.38(a)
      416225  XM_414548.3  XP_414548.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAF26
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343548.1(254294-266361)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844733.12   -- 79.12(n)    BX844733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282272 Danio rerio cDNA clone IMAGE6791245, partial cds 76.11(n)    BC056714.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Faf1 Fas-associated factor 50.5(n)
    44.62(a)
      35129  NM_058040.3  NP_477388.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBX3(YDL091C)4 UBX (ubiquitin regulatory X) domain-containing protein more   --   4(294759-293392) 851467  NP_010192.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G107901 UBX domain-containing protein 44.23(n)
    31.05(a)
      826675  NM_117147.3  NP_192817.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05206001 hypothetical protein 44.4(n)
    34.78(a)
      4349139  NM_001071620.1  NP_001065085.1 


    ENSEMBL Gene Tree for FAF2 (if available)
    TreeFam Gene Tree for FAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAF2 gene
    FAF12  

    FAF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAF2
    PGOHUM00000238582


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1313 SNPs in FAF2 are shown (see all 1313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821322851,2
    --175873434(+) ATTACA/GCAATT 1 -- us2k10--------
    rs1878691141,2
    --175873890(+) GCGCTG/TGGATT 1 -- us2k10--------
    rs1474424781,2
    --175874364(+) GGGACA/GTGCAG 1 -- us2k10--------
    rs77242971,2
    C,F,H--175874497(+) aacaaA/Gtggca 1 -- us2k18Minor allele frequency- G:0.05NS EA WA 1196
    rs1484817621,2
    --175874629(+) GTGCAA/GCGCTA 1 -- us2k10--------
    rs77250801,2
    C,F,H--175874713(+) TGGACG/AGCAAG 1 -- us2k19Minor allele frequency- A:0.05NS EA NA WA 1202
    rs1417625671,2
    --175874823(+) CGAAGC/TCTGCC 1 -- us2k10--------
    rs1925008711,2
    --175874864(+) AATGCC/TGCGCC 1 -- us2k10--------
    rs1432393951,2
    --175874870(+) GCGCCA/CGTATC 1 -- us2k10--------
    rs1396745601,2
    --175874931(+) TAGGTC/TAGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAF2 (175874629 - 175937075 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521107CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAF2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609653   
    OMIM disorders: 252010  256000  
    4 diseases for FAF2:    About MalaCards
    atopic dermatitis    dermatitis    enophthalmos    mitochondrial complex i deficiency

    1 disease from the University of Copenhagen DISEASES database for FAF2:
    Enophthalmos

    FAF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAF2

    Export disorders for FAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAF2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with FAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. (PubMed id 12372427)1, 2, 3, 9 Imai Y.... Oshida T. (2002)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. (PubMed id 19818707)1, 2 Ernst R.... Schlieker C. (2009)
    4. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. (PubMed id 18711132)1, 2 Mueller B.... Ploegh H.L. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The RasGAP proteins Ira2 and neurofibromin are negati vely regulated by Gpb1 in yeast and ETEA in humans. (PubMed id 20160012)1, 9 Phan V.T....McCormick F. (2010)
    7. The p97-UBXD8 complex destabilizes mRNA by promoting r elease of ubiquitinated HuR from mRNP. (PubMed id 23618873)1 Zhou H.L....Lou H. (2013)
    8. A ubiquitin-like domain recruits an oligomeric chapero ne to a retrotranslocation complex in endoplasmic reticulum-associated degradati on. (PubMed id 23665563)1 Xu Y....Ye Y. (2013)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23197 HGNC: 24666 AceView: ETEA Ensembl:ENSG00000113194 euGenes: HUgn23197
    ECgene: FAF2 H-InvDB: FAF2

    (According to HUGE)
    About This Section
    HUGE: KIAA0887

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAF2 gene:
    Search GeneIP for patents involving FAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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