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Aliases for FAF1 Gene

Aliases for FAF1 Gene

  • Fas (TNFRSF6) Associated Factor 1 2 3
  • UBX Domain-Containing Protein 12 3 4
  • UBX Domain-Containing Protein 3A 3 4
  • TNFRSF6-Associated Factor 1 2 3
  • UBX Domain Protein 3A 2 3
  • UBXD12 3 4
  • UBXN3A 3 4
  • HFAF1 3 4
  • FAS-Associated Factor 1 3
  • CGI-03 3
  • HFAF1s 3
  • H 6

External Ids for FAF1 Gene

Summaries for FAF1 Gene

Entrez Gene Summary for FAF1 Gene

  • Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAF1 Gene

FAF1 (Fas (TNFRSF6) Associated Factor 1) is a Protein Coding gene. Among its related pathways are RB in Cancer and Apoptosis and survival Caspase cascade. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is FAF2.

UniProtKB/Swiss-Prot for FAF1 Gene

  • Potentiates but cannot initiate FAS-induced apoptosis

Gene Wiki entry for FAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAF1 Gene

Genomics for FAF1 Gene

Genomic Location for FAF1 Gene

Start:
50,439,478 bp from pter
End:
50,960,264 bp from pter
Size:
520,787 bases
Orientation:
Minus strand

Genomic View for FAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAF1 Gene

Regulatory Elements for FAF1 Gene

Proteins for FAF1 Gene

  • Protein details for FAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNN5-FAF1_HUMAN
    Recommended name:
    FAS-associated factor 1
    Protein Accession:
    Q9UNN5
    Secondary Accessions:
    • Q549F0
    • Q9UF34
    • Q9UNT3
    • Q9Y2Z3

    Protein attributes for FAF1 Gene

    Size:
    650 amino acids
    Molecular mass:
    73954 Da
    Quaternary structure:
    • Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain.
    SequenceCaution:
    • Sequence=AAD51876.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FAF1 Gene

    Alternative splice isoforms for FAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAF1 Gene

Proteomics data for FAF1 Gene at MOPED

Post-translational modifications for FAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys139, Lys143, Lys146, Lys157, and Lys221

Other Protein References for FAF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAF1 Gene

Domains for FAF1 Gene

Gene Families for FAF1 Gene

HGNC:
  • UBXN :UBX domain containing

Protein Domains for FAF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNN5

UniProtKB/Swiss-Prot:

FAF1_HUMAN
Domain:
  • Contains 1 UBA domain.:
    • Q9UNN5
  • Contains 1 UBX domain.:
    • Q9UNN5
genes like me logo Genes that share domains with FAF1: view

Function for FAF1 Gene

Molecular function for FAF1 Gene

GENATLAS Biochemistry: FAS (TNFRSF6) associated factor 1,expressed in testis,skeletal muscle,heart
UniProtKB/Swiss-Prot Function: Potentiates but cannot initiate FAS-induced apoptosis

Gene Ontology (GO) - Molecular Function for FAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15688372
GO:0019887 protein kinase regulator activity NAS 11713579
GO:0019901 protein kinase binding IDA 11713579
GO:0019904 protein domain specific binding IEA --
GO:0031072 heat shock protein binding IDA 15596450
genes like me logo Genes that share ontologies with FAF1: view
genes like me logo Genes that share phenotypes with FAF1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAF1 Gene

Localization for FAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAF1 Gene COMPARTMENTS Subcellular localization image for FAF1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 4
extracellular 1

Gene Ontology (GO) - Cellular Components for FAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15596450
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IDA 15596450
GO:0031265 CD95 death-inducing signaling complex NAS 12702723
genes like me logo Genes that share ontologies with FAF1: view

Pathways for FAF1 Gene

genes like me logo Genes that share pathways with FAF1: view

Pathways by source for FAF1 Gene

1 Cell Signaling Technology pathway for FAF1 Gene

Gene Ontology (GO) - Biological Process for FAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007253 cytoplasmic sequestering of NF-kappaB IMP 14600157
GO:0008219 cell death IMP 15743842
GO:0010942 positive regulation of cell death IDA 15596450
GO:0030155 regulation of cell adhesion IEA --
genes like me logo Genes that share ontologies with FAF1: view

Compounds for FAF1 Gene

(1) Novoseek inferred chemical compound relationships for FAF1 Gene

Compound -log(P) Hits PubMed IDs
etoposide 23.8 1
genes like me logo Genes that share compounds with FAF1: view

Transcripts for FAF1 Gene

Unigene Clusters for FAF1 Gene

Fas (TNFRSF6) associated factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:

Relevant External Links for FAF1 Gene

GeneLoc Exon Structure for
FAF1
ECgene alternative splicing isoforms for
FAF1

Expression for FAF1 Gene

mRNA expression in normal human tissues for FAF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAF1 Gene

SOURCE GeneReport for Unigene cluster for FAF1 Gene Hs.530402

mRNA Expression by UniProt/SwissProt for FAF1 Gene

Q9UNN5-FAF1_HUMAN
Tissue specificity: Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes
genes like me logo Genes that share expressions with FAF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FAF1 Gene

Orthologs for FAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAF1 35
  • 99.9 (n)
  • 99.85 (a)
FAF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAF1 35
  • 95.18 (n)
  • 97.69 (a)
FAF1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAF1 35
  • 94.56 (n)
  • 97.23 (a)
FAF1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faf1 35
  • 92.86 (n)
  • 96.3 (a)
Faf1 16
Faf1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAF1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faf1 35
  • 92.19 (n)
  • 95.22 (a)
chicken
(Gallus gallus)
Aves FAF1 35
  • 85.07 (n)
  • 91.96 (a)
FAF1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAF1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia faf1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia faf1 35
  • 76.22 (n)
  • 85.36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.268 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18567 35
faf1 35
  • 70.74 (n)
  • 79.6 (a)
faf1 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006473 35
  • 48.44 (n)
  • 41.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta casp 35
  • 48.56 (n)
  • 37.95 (a)
casp 36
  • 34 (a)
OneToOne
CG8400 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-23 36
  • 19 (a)
OneToMany
ubxn-3 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX3 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1031 36
  • 34 (a)
OneToOne
Species with no ortholog for FAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAF1 Gene

ENSEMBL:
Gene Tree for FAF1 (if available)
TreeFam:
Gene Tree for FAF1 (if available)

Paralogs for FAF1 Gene

Paralogs for FAF1 Gene

genes like me logo Genes that share paralogs with FAF1: view

Variants for FAF1 Gene

Sequence variations from dbSNP and Humsavar for FAF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2690 -- 50,826,683(-) atctg(G/T)gggga intron-variant
rs718257 -- 50,445,485(-) TCTTT(C/T)TCTAT intron-variant
rs946499 -- 50,793,704(-) ACAAT(A/G)AAGGT intron-variant
rs956084 -- 50,445,675(-) AGAGA(A/G)TCGAT intron-variant
rs967584 -- 50,576,857(+) gatgg(G/T)gatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAF1 Gene

Variant ID Type Subtype PubMed ID
esv268665 CNV Insertion 20981092
esv274345 CNV Insertion 20981092
esv268038 CNV Insertion 20981092
esv269208 CNV Insertion 20981092
esv272813 CNV Insertion 20981092
esv269625 CNV Insertion 20981092
nsv821 CNV Insertion 18451855
esv2748096 CNV Deletion 23290073
esv2676818 CNV Deletion 23128226
esv2662887 CNV Deletion 23128226
nsv832 CNV Loss 18451855
dgv224n71 CNV Loss 21882294
dgv225n71 CNV Loss 21882294
nsv870748 CNV Loss 21882294

Relevant External Links for FAF1 Gene

HapMap Linkage Disequilibrium report
FAF1
Human Gene Mutation Database (HGMD)
FAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAF1 Gene

Disorders for FAF1 Gene

(3) Novoseek inferred disease relationships for FAF1 Gene

Disease -log(P) Hits PubMed IDs
gastric carcinoma 31 6
tumors 9.08 6
necrosis 0 2

Relevant External Links for FAF1

Genetic Association Database (GAD)
FAF1
Human Genome Epidemiology (HuGE) Navigator
FAF1
genes like me logo Genes that share disorders with FAF1: view

No data available for UniProtKB/Swiss-Prot for FAF1 Gene

Publications for FAF1 Gene

  1. Identification and characterization of human Fas associated factor 1, hFAF1. (PMID: 10462485) Ryu S.-W. … Kim E. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. The UBX domain: a widespread ubiquitin-like module. (PMID: 11243799) Buchberger A. … Bycroft M.M. (J. Mol. Biol. 2001) 3 4 23
  3. Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. (PMID: 19722279) Song J. … Kim E.E. (Protein Sci. 2009) 3 4 23
  4. Crystallization and preliminary X-ray crystallographic analysis of the N domain of p97/VCP in complex with the UBX domain of FAF1. (PMID: 20057067) Shin H.Y. … Yang J.K. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23
  5. Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain. (PMID: 20124726) Kang W. … Yang J.K. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23

Products for FAF1 Gene

Sources for FAF1 Gene

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