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FAF1 Gene

protein-coding   GIFtS: 57
GCID: GC01M050905

Fas (TNFRSF6) Associated Factor 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fas (TNFRSF6) Associated Factor 11 2     UBX Domain-Containing Protein 122 3
TNFRSF6-Associated Factor 11 2     UBX Domain-Containing Protein 3A2 3
UBX Domain Protein 3A1 2     HFAF1s2
UBXD122 3     FAS-Associated Factor 12
UBXN3A2 3     H5
hFAF12 3     

External Ids:    HGNC: 35781   Entrez Gene: 111242   Ensembl: ENSG000001851047   OMIM: 6044605   UniProtKB: Q9UNN53   

Export aliases for FAF1 gene to outside databases

Previous GC identifers: GC01M050531 GC01M049795 GC01M050265 GC01M050276 GC01M050618 GC01M050679 GC01M049025


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAF1 Gene:
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called
apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate
apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by
this gene requires a ubiquitin-like domain but not the FAS-binding domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAF1 Gene:
FAF1 (Fas (TNFRSF6) associated factor 1) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is FAF2.

UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
Function: Potentiates but cannot initiate FAS-induced apoptosis

Gene Wiki entry for FAF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAF1 gene promoter:
         GR   p53   IRF-1   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAF1 promoter sequence
   Search Chromatin IP Primers for FAF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

FAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M050905:  view genomic region     (about GC identifiers)

Start:
50,905,150 bp from pter      End:
51,425,936 bp from pter
Size:
520,787 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5 (See protein sequence)
Recommended Name: FAS-associated factor 1  
Size: 650 amino acids; 73954 Da
Subunit: Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via
its UBA domain
Sequence caution: Sequence=AAD51876.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for FAF1 (see all 10):
1H8C (3D)        2DZM (3D)        2EC4 (3D)        3E21 (3D)        3QC8 (3D)        3QCA (3D)    
Secondary accessions: Q549F0 Q9UF34 Q9UNT3 Q9Y2Z3
Alternative splicing: 2 isoforms:  Q9UNN5-1   Q9UNN5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAF1: NX_Q9UNN5

Explore proteomics data for FAF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys139, Lys143, Lys146, Lys157, Lys221
  • Modification sites at PhosphoSitePlus

  • See FAF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008982.1  
    ENSEMBL proteins: 
     ENSP00000379457   ENSP00000434929   ENSP00000360843   ENSP00000438870  

    FAF1 Human Recombinant Protein Products:

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    Novus Biologicals FAF1 Proteins
    Novus Biologicals FAF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAF1

     
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    antibodies-online proteins for FAF1 (9 products) 

     
    antibodies-online peptides for FAF1

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    Abcam antibodies for FAF1
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    antibodies-online antibodies for FAF1 (55 products) 

    FAF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for FAF1
    Cloud-Clone Corp. CLIAs for FAF1
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    antibodies-online kits for FAF1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBXN: UBX domain containing

    3 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR006577 UAS
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry Q9UNN5

    ProtoNet protein and cluster: Q9UNN5

    2 Blocks protein domains:
    IPB001012 UBX domain
    IPB006577 UAS


    UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 UBX domain


    Find genes that share domains with FAF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAF1_HUMAN, Q9UNN5
    Function: Potentiates but cannot initiate FAS-induced apoptosis

         Genatlas biochemistry entry for FAF1:
    FAS (TNFRSF6) associated factor 1,expressed in testis,skeletal muscle,heart

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15688372
    GO:0019887protein kinase regulator activity NAS11713579
    GO:0019901protein kinase binding IDA11713579
    GO:0019904protein domain specific binding IEA--
    GO:0031072heat shock protein binding IDA15596450
         
    Find genes that share ontologies with FAF1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FAF1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Faf1):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 

    Find genes that share phenotypes with FAF1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAF1:
    hsa-mir-193b-3p (MIRT041238), hsa-mir-146a-5p (MIRT003319), hsa-mir-26b-5p (MIRT029548), hsa-mir-24-3p (MIRT006507), hsa-mir-92a-3p (MIRT049059), hsa-mir-484 (MIRT041754)

    Block miRNA regulation of human, mouse, rat FAF1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAF1:
    hsa-miR-562 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFAF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAF1
    Predesigned siRNA for gene silencing in human, mouse, rat FAF1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAF1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAF1_HUMAN, Q9UNN5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    endoplasmic reticulum4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15596450
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA15596450
    GO:0031265CD95 death-inducing signaling complex NAS12702723

    Find genes that share ontologies with FAF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    FAS pathway and Stress induction of HSP regulation0.44
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    3RB in Cancer
    RB in Cancer
    4Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with FAF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FAF1
        Apoptosis and Autophagy

    3 BioSystems Pathways for FAF1
        FAS pathway and Stress induction of HSP regulation
    TNF-alpha/NF-kB Signaling Pathway
    RB in Cancer


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FAF1: 
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FAF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FAF1 (Q9UNN52, 3 ENSP000003794574) via UniProtKB, MINT, STRING, and/or I2D (see all 655)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J92, 3MINT-7947479 MINT-8251098 I2D: score=2 
    ASCC2Q9H1I82, 3MINT-65486 I2D: score=5 
    SKILP127572, 3MINT-61654 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62159 I2D: score=3 
    ANXA1P040832, 3MINT-8247786 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007253cytoplasmic sequestering of NF-kappaB IMP14600157
    GO:0008219cell death IMP15743842
    GO:0030155regulation of cell adhesion IEA--
    GO:0031334positive regulation of protein complex assembly IMP15688372

    Find genes that share ontologies with FAF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAF1

    1 Novoseek inferred chemical compound relationship for FAF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etoposide 23.8 1 15688372 (1)



    Find genes that share compounds with FAF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAF1 gene (2 alternative transcripts): 
    NM_007051.2  NM_131917.1  

    Unigene Cluster for FAF1:

    Fas (TNFRSF6) associated factor 1
    Hs.530402  [show with all ESTs]
    Unigene Representative Sequence: NM_007051
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396153(uc001cse.1) ENST00000494400 ENST00000472808 ENST00000487898
    ENST00000371778(uc009vyw.1) ENST00000545823(uc010onc.1)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FAF1:
    hsa-miR-562 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidFAF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAF1
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAF1
      QuantiTect SYBR Green Assays in human, mouse, rat FAF1
      QuantiFast Probe-based Assays in human, mouse, rat FAF1

    Additional mRNA sequence: 

    AF094700.1 AF106798.1 AF132938.1 AF136173.1 AJ271408.1 AK094843.1 AK292840.1 AK293659.1 
    AL133631.1 BC004970.1 BC067100.1 

    20 DOTS entries:

    DT.417221  DT.99942897  DT.100736453  DT.100792849  DT.100829079  DT.121349269  DT.91778267  DT.100792855 
    DT.91778265  DT.100792848  DT.91778263  DT.95235768  DT.121349127  DT.121349323  DT.86849719  DT.91778272 
    DT.95235712  DT.95235716  DT.95235718  DT.417222 

    Selected AceView cDNA sequences (see all 422):

    CA419547 BM987396 BG105918 BU676851 Z39834 BQ217961 BU855025 AI926499 
    AW294322 BU156873 BQ925305 BU500561 BU688116 BE169095 T66179 BU732335 
    BG473098 AL133631 AI476230 AF136173 BU616224 BE257396 AI221931 BG252131 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                  -                                                         
    SP2:                                                                                            -               
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for FAF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGAGTAC
    FAF1 Expression
    About this image

    FAF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530402

    UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
    Tissue specificity: Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by
    prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FAF1: 
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAF1
    OriGene qSTAR qPCR primer pairs in human, mouse for FAF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAF1
    QuantiTect SYBR Green Assays in human, mouse, rat FAF1
    QuantiFast Probe-based Assays in human, mouse, rat FAF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAF1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faf11 , 5 Fas-associated factor 11, 5 92.86(n)1
    96.3(a)1
      4 (51.33 cM)5
    140841  NM_007983.21  NP_032009.21 
     1096765885 
    chicken
    (Gallus gallus)
    Aves FAF11 Fas (TNFRSF6) associated factor 1 85.07(n)
    91.96(a)
      424629  XM_422464.4  XP_422464.4 
    lizard
    (Anolis carolinensis)
    Reptilia FAF16
    Fas (TNFRSF6) associated factor 1
    89(a)
    1 ↔ 1
    4(113537776-113786554)
    African clawed frog
    (Xenopus laevis)
    Amphibia faf1-prov2 Fas (TNFRSF6) associated factor 1 78.49(n)    BC045062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185672 Danio rerio Fas-associated factor 1 mRNA, complete more 76.96(n)    BC048887.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84003
    casp1
    caspar1 32(a)3
    48.56(n)1
    37.95(a)1
      367691  NM_137236.41  NP_611080.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubxn-36
    ubc-236
    Protein UBC-23 (ubc-23) mRNA, complete cds
    21(a)
    19(a)
    1 ↔ many
    1 ↔ many
    II(217265-220642) WBGene00018586
    X(8844288-8846275) WBGene00006718
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBX36
    UBX (ubiquitin regulatory X) domain-containing pro...
    20(a)
    1 → many
    IV(293392-294759) YDL091C


    ENSEMBL Gene Tree for FAF1 (if available)
    TreeFam Gene Tree for FAF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAF1 gene
    FAF22  

    Find genes that share paralogs with FAF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAF1 (see all 8514)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447465151,2
    --50906489(+) ACCTGC/GAGACC 1 -- ds50010--------
    rs1136529581,2
    F--50906500(+) CAAGGC/TAGCAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs412868211,2
    --50906516(+) AATAAA/TTATCT 1 -- ds50010--------
    rs740825241,2
    C--50906712(+) AATAAA/GAAGAC 1 -- ds50012Minor allele frequency- G:0.04WA 120
    rs1893049081,2
    --50906777(+) CACTGC/TGGGGA 1 -- ds50010--------
    rs1807956461,2
    --50906822(+) AGTGAC/TCACTC 1 -- ds50010--------
    rs1506830211,2
    C--50906872(+) TGCAGG/TGGGTA 1 -- ds50010--------
    rs1865269331,2
    --50907027(+) CGAGCA/GTGTGG 1 -- ut310--------
    rs1913824801,2
    --50907042(+) GTTGGC/TGAGGA 1 -- ut310--------
    rs2007108231,2
    --50907108(+) GGGCCC/GTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAF1 (50905150 - 51155150 bp, first 250kb of FAF1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAF1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662887CNV Deletion23128226
    esv2676818CNV Deletion23128226
    esv2748096CNV Deletion23290073
    esv268665CNV Insertion20981092
    esv274345CNV Insertion20981092
    nsv821CNV Insertion18451855
    esv269625CNV Insertion20981092
    esv268038CNV Insertion20981092
    esv272813CNV Insertion20981092
    esv269208CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604460    OMIM disorders: --


    Find genes that share disorders with FAF1           About GenesLikeMe

    3 Novoseek inferred disease relationships for FAF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric carcinoma 31 9 12963981 (5), 15688372 (1)
    tumors 9.08 6 17684021 (1), 14600157 (1), 19597341 (1), 12963981 (1) (see all 6)
    necrosis 0 2 17684021 (1), 14600157 (1)

    Genetic Association Database (GAD): FAF1
    Human Genome Epidemiology (HuGE) Navigator: FAF1 (9 documents)

    Export disorders for FAF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAF1 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with FAF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human Fas associated factor 1, hFAF1. (PubMed id 10462485)1, 2, 3, 9 Ryu S.-W.... Kim E. (Biochem. Biophys. Res. Commun. 1999)
    2. Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. (PubMed id 19722279)1, 2, 9 Song J.... Kim E.E. (Protein Sci. 2009)
    3. The UBX domain: a widespread ubiquitin-like module. (PubMed id 11243799)1, 2, 9 Buchberger A.... Bycroft M.M. (J. Mol. Biol. 2001)
    4. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (PubMed id 22064162)1, 4 Edwards A.C....Dick D.M. (Psychiatr. Genet. 2012)
    5. The NLRP12 pyrin domain: structure, dynamics, and functional insights. (PubMed id 21978668)1, 2 Pinheiro A.S.... Peti W. (J. Mol. Biol. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (PLoS ONE 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)
    10. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11124 HGNC: 3578 AceView: FAF1 Ensembl:ENSG00000185104 euGenes: HUgn11124
    ECgene: FAF1 H-InvDB: FAF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAF1 gene:
    Search GeneIP for patents involving FAF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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