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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAF1 Gene

protein-coding   GIFtS: 56
GCID: GC01M050905

Fas (TNFRSF6) associated factor 1

 Explore 17 diseases affiliated with
FAF1 via our new
 Human Malady Compendium 
Biological research products
for FAF1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fas (TNFRSF6) Associated Factor 11 2     UBX Domain-Containing Protein 3A2 3
UBXD121 2 3     CGI-031
UBXN3A1 2 3     FAS-Associated Factor 12
HFAF11     TNFRSF6-Associated Factor 12
HFAF1s1 2     UBX Domain Protein 3A2
UBX Domain-Containing Protein 122 3     

External Ids:    HGNC: 35781   Entrez Gene: 111242   Ensembl: ENSG000001851047   OMIM: 6044605   UniProtKB: Q9UNN53   

Export aliases for FAF1 gene to outside databases

Previous GC identifers: GC01M050531 GC01M049795 GC01M050265 GC01M050276 GC01M050618 GC01M050679 GC01M049025


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAF1:
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called
apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate
apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this
gene requires a ubiquitin-like domain but not the FAS-binding domain. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
Function: Potentiates but cannot initiate FAS-induced apoptosis

Gene Wiki entry for FAF1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAF1 gene promoter:
         GR   p53   IRF-1   GR-alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

FAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M050905:  view genomic region     (about GC identifiers)

Start:
50,905,150 bp from pter      End:
51,425,936 bp from pter
Size:
520,787 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5 (See protein sequence)
Recommended Name: FAS-associated factor 1  
Size: 650 amino acids; 73954 Da
Subunit: Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via its
UBA domain
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAD51876.1; Type=Erroneous initiation;
6/10 PDB 3D structures from and Proteopedia for FAF1 (see all 10):
1H8C (3D)        2DZM (3D)        2EC4 (3D)        3E21 (3D)        3QC8 (3D)        3QCA (3D)    
Secondary accessions: Q549F0 Q9UF34 Q9UNT3 Q9Y2Z3
Alternative splicing: 2 isoforms:  Q9UNN5-1   Q9UNN5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAF1: NX_Q9UNN5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNN5

  • FAF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008982.1  
    ENSEMBL proteins: 
     ENSP00000379457   ENSP00000360845   ENSP00000434929   ENSP00000360843   ENSP00000438870  

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    Uscn Proteins for FAF1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15596450
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA15596450
    GO:0031265CD95 death-inducing signaling complex NAS12702723


    FAF1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FAF1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006577 UAS
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry Q9UNN5

    ProtoNet protein and cluster: Q9UNN5

    2 Blocks protein families:
    IPB001012 UBX domain
    IPB006577 UAS


    UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 UBX domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
    Function: Potentiates but cannot initiate FAS-induced apoptosis

         Genatlas biochemistry entry for FAF1:
    FAS (TNFRSF6) associated factor 1,expressed in testis,skeletal muscle,heart

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAF1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15688372
    GO:0019887protein kinase regulator activity NAS11713579
    GO:0019901protein kinase binding IDA11713579
    GO:0019904protein domain specific binding IEA--
    GO:0031072heat shock protein binding IDA15596450


    FAF1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for FAF1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Faf1):
     mortality/aging 

    FAF1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    Apoptosis and Autophagy1.00
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway1.00
    3Apoptosis and survival_Caspase cascade
    FAS pathway and Stress induction of HSP regulation0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FAF1
        Apoptosis and Autophagy

    2 BioSystems Pathways for FAF1 
        FAS pathway and Stress induction of HSP regulation
    TNF-alpha/NF-kB Signaling Pathway



    FAF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FAF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/598 Interacting proteins for FAF1 (Q9UNN52, 3 ENSP000003794574) via UniProtKB, MINT, STRING, and/or I2D (see all 598)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J92, 3MINT-7947479 MINT-8251098 I2D: score=2 
    CUL1Q136162, 3, ENSP000003268044MINT-7947479 I2D: score=2 STRING: ENSP00000326804
    ASCC2Q9H1I82, 3MINT-65486 I2D: score=5 
    SKILP127572, 3MINT-61654 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62159 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007253cytoplasmic sequestering of NF-kappaB IMP14600157
    GO:0008219cell death IMP15743842
    GO:0030155regulation of cell adhesion IEA--
    GO:0031334positive regulation of protein complex assembly IMP15688372


    FAF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FAF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAF1
    1 Novoseek chemical compound relationship for FAF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etoposide 23.8 1 15688372 (1)

    Search CenterWatch for drugs/clinical trials and news about FAF1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAF1 gene (2 alternative transcripts): 
    NM_007051.2  NM_131917.1  

    Unigene Cluster for FAF1:

    Fas (TNFRSF6) associated factor 1
    Hs.530402  [show with all ESTs]
    Unigene Representative Sequence: NM_007051
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396153(uc001cse.1) ENST00000371780 ENST00000494400 ENST00000472808
    ENST00000487898 ENST00000371778(uc009vyw.1) ENST00000545823(uc010onc.1)


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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAF1

    Additional cDNA sequence: 

    AF094700.1 AF106798.1 AF132938.1 AF136173.1 AJ271408.1 AK094843.1 AK292840.1 AK293659.1 
    AL133631.1 BC004970.1 BC067100.1 

    20 DOTS entries:

    DT.417221  DT.99942897  DT.100736453  DT.100792849  DT.100829079  DT.121349269  DT.91778267  DT.100792855 
    DT.91778265  DT.100792848  DT.91778263  DT.95235768  DT.121349127  DT.121349323  DT.86849719  DT.91778272 
    DT.95235712  DT.95235716  DT.95235718  DT.417222 

    24/422 AceView cDNA sequences (see all 422):

    BM694160 AK130902 CA419547 BQ184657 T66179 BU500561 BU171572 AI221931 
    BG252131 CA415726 BQ010265 BU156873 Z40510 BQ680323 AW294322 AL133631 
    AJ346190 BQ017098 AA359273 BG763281 BQ050271 BF197368 BE169111 BQ677973 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                  -                                                         
    SP2:                                                                                            -               
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for FAF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATGAGTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FAF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAF1

    SOURCE GeneReport for Unigene cluster: Hs.530402

    UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5
    Tissue specificity: Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate,
    thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including FAF1: 
              TNF Ligands & Receptors in human mouse rat
              Necrosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAF1 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FAF11 Fas (TNFRSF6) associated factor 1 85.2(n)
    92.28(a)
      424629  XM_422464.3  XP_422464.3 
    lizard
    (Anolis carolinensis)
    Reptilia FAF16
    --
    84(a)
    1 ↔ 1
    4(113541042-113633760)
    African clawed frog
    (Xenopus laevis)
    Amphibia faf1-prov2 Fas (TNFRSF6) associated factor 1 78.49(n)    BC045062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185672 Danio rerio Fas-associated factor 1 mRNA, complete more 76.96(n)    BC048887.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84003
    casp1
    caspar1 32(a)3
    48.05(n)1
    37.6(a)1
      367691  NM_137236.41  NP_611080.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubxn-36
    ubc-236
    UBX-containing protein in Nematode family member (...
    UBiquitin Conjugating enzyme family member (ubc-23...
    21(a)
    15(a)
    1 ↔ many
    1 ↔ many
    II(217265-220642)
    X(8844233-8848504)


    ENSEMBL Gene Tree for FAF1 (if available)
    TreeFam Gene Tree for FAF1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAF1 gene
    FAF22  

    FAF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7166 NCBI SNPs in FAF1 are shown (see all 7166    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447465151,2
    --50906489(+) ACCTGC/GAGACC 1 -- ds50010--------
    rs1136529581,2
    --50906500(+) CAAGGC/TAGCAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs412868211,2
    --50906516(+) AATAAA/TTATCT 1 -- ds50010--------
    rs740825241,2
    C,--50906712(+) AATAAA/GAAGAC 1 -- ds50012Minor allele frequency- G:0.04WA 120
    rs1893049081,2
    --50906777(+) CACTGC/TGGGGA 1 -- ds50010--------
    rs1807956461,2
    --50906822(+) AGTGAC/TCACTC 1 -- ds50010--------
    rs1506830211,2
    --50906872(+) TGCAGG/TGGGTA 1 -- ds50010--------
    rs1865269331,2
    --50907027(+) CGAGCA/GTGTGG 1 -- ut310--------
    rs1913824801,2
    --50907042(+) GTTGGC/TGAGGA 1 -- ut310--------
    rs2007108231,2
    --50907108(+) GGGCCC/GTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAF1 (50905150 - 51155150 bp, first 250kb of FAF1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FAF1
         2 CNVs: 84227 84228

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAF1 for disorders           About GeneDecksing

    OMIM gene information: 604460    OMIM disorders: --

    17 diseases for FAF1:    About MalaCards
    familial atrial fibrillation    autoimmune lymphoproliferative syndrome    lymphoproliferative syndrome    atrial fibrillation
    mantle cell lymphoma    cleft palate    atopic dermatitis    dermatitis
    crohn's disease    hepatitis b    parkinson's disease    lung carcinoma
    hepatitis    carcinoma    malaria    prostatitis
    neuronitis

    3 Novoseek disease relationships for FAF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric carcinoma 31 9 12963981 (5), 15688372 (1)
    tumors 9.08 6 17684021 (1), 14600157 (1), 19597341 (1), 12963981 (1) (see all 6)
    necrosis 0 2 17684021 (1), 14600157 (1)

    Human Genome Epidemiology (HuGE) Navigator: FAF1 (9 documents)

    Export disorders for FAF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAF1 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with FAF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human Fas associated factor 1, hFAF1. (PubMed id 10462485)1, 2, 3, 9 Ryu S.-W.... Kim E. (1999)
    2. Structure and interaction of ubiquitin-associated dom ain of human Fas-associated factor 1. (PubMed id 19722279)1, 2, 9 Song J....Kim E.E. (2009)
    3. The UBX domain: a widespread ubiquitin-like module. (PubMed id 11243799)1, 2, 9 Buchberger A.... Bycroft M.M. (2001)
    4. The NLRP12 pyrin domain: structure, dynamics, and fun ctional insights. (PubMed id 21978668)1, 2 Pinheiro A.S....Peti W. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    7. Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. (PubMed id 12702723)1, 9 Ryu S.W....Kim E. (2003)
    8. The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. (PubMed id 12963981)1, 9 Bjorling-Poulsen M....Issinger O.G. (2003)
    9. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. (PubMed id 15688372)1, 9 Park M.Y....Kim E. (2005)
    10. Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. (PubMed id 14600157)1, 9 Park M.Y....Kim E. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11124 HGNC: 3578 AceView: FAF1 Ensembl:ENSG00000185104 euGenes: HUgn11124
    ECgene: FAF1 H-InvDB: FAF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAF1 gene:
    Search GeneIP for patents involving FAF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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