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Aliases & Descriptions for FAF1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CGI-03 1, 2 | | FLJ37524 2 | | HFAF1s 1, 2 | | UBXD12 1, 2, 3 | | UBXN3A 1, 2, 3 | | hFAF1 1, 2, 3 |
| | | Descriptions |
|---|
| FAS-associated factor 1 2 | | Fas (TNFRSF6) associated factor 1 2 | | Fas associated factor 1 1 | | TNFRSF6-associated factor 1 2 | | UBX domain protein 3A 2 | | UBX domain-containing protein 12 3 | | UBX domain-containing protein 3A 3 |
|
| | Search outside databases for aliases for FAF1 genePrevious GC identifers: GC01M050531 GC01M049795 GC01M050265 GC01M050276 GC01M050618 |
Summaries for FAF1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FAF1: Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq] UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5Function: Potentiates but cannot initiate FAS-induced apoptosisGene Wiki entry for FAF1 |
Genomic Location for FAF1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FAF1 gene 
Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1pter-qterFAF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M050679:
(about GC identifiers)
Start:
|
50,679,523 bp from pter |
End:
|
51,198,524 bp from pter |
Size:
|
519,002 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for FAF1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5 (See
protein sequence)Recommended Name: FAS-associated factor 1 Size: 650 amino acids; 73954 Da
Subunit: Specifically interacts with the cytoplasmic domain of FAS
Subcellular location: Nucleus (Potential)
PDB structures from and Proteopedia :1H8C (3D)
 2DZM (3D)
 2EC4 (3D)
 
Secondary accessions: Q9UF34 Q9UNT3 Q9Y2Z3Alternative splicing: 2 isoforms: Q9UNN5-1 Q9UNN5-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_008982.1
ENSEMBL proteins: ENSP00000332342 ENSP00000360843 ENSP00000360845 ENSP00000379457
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FAF1 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for FAF1: Assays for FAF1: | Protein
Domains/ Families for FAF1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UNN5
ProtoNet protein and cluster: Q9UNN5 2 Blocks protein families: IPB001012 UBX domain IPB006577 UAS
UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5Similarity: Contains 1 UBX domain | Gene Function for FAF1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007051
Applied Biosystems Silencer® siRNAs for FAF1
Sigma-Aldrich siRNA and siRNA Panels for FAF1  Sigma-Aldrich shRNA Panels and shRNA for FAF1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007051                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007051                                  untagged cDNA clones in CMV expression vector (see all 2): NM_007051 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007051
UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5Function: Potentiates but cannot initiate FAS-induced apoptosisGenatlas biochemistry entry for FAF1:FAS (TNFRSF6) associated factor 1,expressed in testis,skeletal muscle,heart1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Faf1):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FAF1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for FAF1 
3 Interacting proteins for FAF1 (Q9UNN52) via UniProtKB, MINT, and/or STRINGAbout this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): About this table
|
Drugs & Compounds for FAF1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FAF1
|
Transcripts for FAF1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007051
Sigma-Aldrich siRNA and siRNA Panels for FAF1  Sigma-Aldrich shRNA Panels and shRNA for FAF1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_007051 REFSEQ mRNAs for FAF1 gene: NM_007051.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007051               OriGene GFP tagged cDNA clone in CMV expression vector: NM_007051                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_007051                                  untagged cDNA clones in CMV expression vector (see all 2): NM_007051  Additional cDNA sequence: AF094700.1 AF106798.1 AF132938.1 AF136173.1 AJ271408.1 AK094843.1 AK292840.1 AK293659.1 AL133631.1 BC004970.1 BC067100.1 CR611648.1 CR625260.1 20 DOTS entries: DT.417221 DT.99942897 DT.100736453 DT.100792849 DT.100829079 DT.121349269 DT.91778267 DT.100792855 DT.91778265 DT.100792848 DT.417222 DT.91778263 DT.95235768 DT.121349127 DT.121349323 DT.86849719 DT.91778272 DT.95235712 DT.95235716 DT.95235718 24/422 AceView cDNA sequences (see all 422
):BQ677973 AI221931 BU500561 AW294322 BU171572 CA419547 BQ680323 CA434413 BU608834 Z45839 BM980238 BU855025 CF541324 BQ050271 AA359273 CR625260 AI698159 BQ011849 AA962542 BC004970 AI926499 BQ962561 AI361685 BQ925305
highest scoring ESTs for FAF1:AI832222 AA355806 AI318079 AI421095 AI923636 AW140098 AW292106 AW294322 AW452108 AW575687 Unigene Cluster for FAF1: Fas (TNFRSF6) associated factor 1 Hs.530402 [show with all ESTs]Unigene Representative Sequence: NM_007051
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FAF1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for FAF1
4 Ensembl transcripts including schematic representations: ENST00000345470
ENST00000371778
ENST00000371780
ENST00000396153
|
Expression for FAF1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FAF1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FAF1
1 / 2 / 3 8 probe-sets matching FAF1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGATGAGTAC
SOURCE GeneReport for Unigene cluster: Hs.530402 UniProtKB/Swiss-Prot: FAF1_HUMAN, Q9UNN5Tissue specificity: Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes |
Orthologs for FAF1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FAF1 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for FAF1
ENSEMBL Gene Tree for FAF1 | Paralogs for FAF1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FAF1 gene
- FAF22
|
SNPs/Variants for FAF1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FAF1 (up to first 250kb)
|
Disorders & Mutations for FAF1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604460
3 Novoseek disease relationships for FAF1 gene
About this table
Human Genome Epidemiology Navigator: FAF1 (2 documents)
|
Medical News for FAF1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FAF1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/39 PubMed articles for FAF1 gene (see all 39
):- Identification and characterization of human Fas associated factor 1, hFAF1. (PubMed id 10462485)1, 2, 3, 4 Ryu S.-W.... Kim E. (1999)
- The UBX domain: a widespread ubiquitin-like module. (PubMed id 11243799)1, 3, 4 Buchberger A.... Bycroft M.M. (2001)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)3, 4 Lai C.H....Lin W. (2000)
- Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. (PubMed id 12702723)1, 3 Ryu S.W....Kim E. (2003)
- The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. (PubMed id 12963981)1, 3 Bjorling-Poulsen M....Issinger O.G. (2003)
- Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. (PubMed id 15688372)1, 3 Park M.Y....Kim E. (2005)
- Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. (PubMed id 14600157)1, 3 Park M.Y....Kim E. (2004)
- FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PubMed id 17684021)1, 3 Park M.Y....Kim E. (2007)
|
Search for FAF1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAF1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FAF1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAF1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FAF1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FAF1:

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Incremental update: 13 Oct 2009
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