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FADS6 Gene

protein-coding GIFtS: 40

GC17M070386

fatty acid desaturase domain family, member 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 1.14.19.- ^³
FP18279 ^²

Descriptions
fatty acid desaturase domain family, member 6 ^²

External Ids
HGNC: 30459¹
Entrez Gene: 283985²
UniProtKB: Q8N9I5³
Ensembl: ENSG00000172782⁷

Search outside databases for aliases for FADS6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FADS6 gene

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

FADS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M070386: (about GC identifiers)

Start:	70,385,068 bp from pter
End:	70,401,310 bp from pter
Size:	16,243 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FADS6_HUMAN, Q8N9I5 (See protein sequence)

Recommended Name: Fatty acid desaturase 6

Size: 356 amino acids; 40447 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=BAC04349.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains

a duplication of the repeated 'MEPTEP' sequence. It is unclear whether such duplication is due to

a sequencing error or a polymorphism;

Secondary accessions: Q17RQ7 Q6XYE1

Alternative splicing: 2 isoforms: Q8N9I5-1 Q8N9I5-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_835229.2

ENSEMBL proteins:

ENSP00000307821

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for FADS6:

	Browse Antibodies Central at Invitrogen
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FADS6

Assays for FADS6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N9I5

ProtoNet protein and cluster: Q8N9I5

UniProtKB/Swiss-Prot: FADS6_HUMAN, Q8N9I5

Similarity: Belongs to the fatty acid desaturase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADS6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178128

Applied Biosystems Silencer® siRNAs for FADS6

Sigma-Aldrich siRNA for FADS6

Sigma-Aldrich shRNA for FADS6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_178128
Myc/DDK tagged cDNA clone in CMV expression vector: NM_178128
untagged cDNA clone in CMV expression vector: NM_178128

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_178128

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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UniProtKB/Swiss-Prot: FADS6_HUMAN, Q8N9I5

Pathway: Lipid metabolism; fatty acid metabolism

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FADS6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADS6)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178128

Sigma-Aldrich siRNA for FADS6

Sigma-Aldrich shRNA for FADS6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_178128

REFSEQ mRNAs for FADS6 gene:

NM_178128.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_178128

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178128
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178128
                                 untagged cDNA clone in CMV expression vector: NM_178128

Additional cDNA sequence:

AK094411.1 AK293720.1 AY203929.1 BC117230.1

3 DOTS entries:

DT.99930267 DT.120974581 DT.91652998

4 AceView cDNA sequences:

BG696484 AK094411 NM_178128 AY203929

highest scoring ESTs for FADS6:

AK094411 AY203929 NM_178128 BC117230 BG696484 DA015566 DA017452 DA067935 DA086966 DA118590

Unigene Cluster for FADS6:

Fatty acid desaturase domain family, member 6

Hs.448845 [show with all ESTs]

Unigene Representative Sequence: AY203929

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FADS6

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5
SP1:
SP2:			-

About this scheme

ECgene alternative splicing isoforms for FADS6

1 Ensembl transcript including schematic representation:

ENST00000310226

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FADS6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FADS6

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.448845

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FADS6 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FADS6¹	--	fatty acid desaturase domain family, member 6	85.9(n) 85.21(a)	609709 XM_847025.1 XP_852118.1
chimpanzee (Pan troglodytes)	FADS6¹	--	fatty acid desaturase domain family, member 6	98.95(n) 98.85(a)	736046 XM_001135764.1 XP_001135764.1
cow (Bos taurus)	FADS6¹	--	fatty acid desaturase domain family, member 6	87.57(n) 86.09(a)	523867 XM_602176.3 XP_602176.2
rat (Rattus norvegicus)	Fads6¹	--	fatty acid desaturase domain family, member 6	81.76(n) 80.47(a)	303671 XM_221105.4 XP_221105.4
mouse (Mus musculus)	Fads6^{1, 5}	11⁵	fatty acid desaturase domain family, member 6^{1, 5}	82.25(n)¹ 80.77(a)¹	328035¹ NM_178035.3¹ NP_828874.2¹ AB087501⁵ AB087503⁵ (see all 12)

About this table Species with no ortholog for FADS6

ENSEMBL Gene Tree for FADS6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/130 NCBI SNPs in FADS6 are shown (see all 130 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 87)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs689992^1,2	A,C,F,H	70402069(-)	`TGTGTA/TTTCCC`	1	--	ng3¹		16		EA NA EU WA	1468
	rs7219093^1,2	C,F,H	70388807(+)	`GTTGAC/TGTGGA`	1	V/I	mis¹ ese³		8		EU EA WA NA	768
	rs690124^1,2	C,F,H	70385847(-)	`CTGGGG/TGAAGC`	1	--	ut3¹		13		MN EA NA EU WA	1174
	rs690019^1,2	A,C,F	70401787(-)	`CATGTG/ATGTCA`	1	--	ng3¹		1		MN	184
	rs690115^1,2	C,F,H	70385664(-)	`AGAGAG/ACAGGG`	1	--	ut3¹ ese³		9		EA NA EU WA	662
	rs550347^1,2	C,F	70402432(+)	`AGAAGT/CTGGGT`	1	--	ng3¹		1		MN	184
	rs525617^1,2	A,F	70402052(+)	`TGAGAC/GGGGTA`	1	--	ng3¹		1		MN	184
--	rs11871284^1,2	A,C	70402976(+)	`CTTGAA/GGTCAG`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs552136^1,2	A,C	70402618(+)	`ttcctG/Aggctc`	1	--	ng3¹		3		EA NA	50
--	rs12952826^1,2	C,H	70387259(+)	`TCATGT/GGAATC`	1	P/H	mis¹ ese³		4		EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for FADS6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for FADS6 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)⁴ Wan D....Gu J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Sequence variation and genomic organization of fatty acid desaturase-2 (fad2) and fatty acid desaturase-6 (fad6) cDNAs in maize. (PubMed id 12677402)¹ Mikkilineni V. and Rocheford T.R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 283985	HGNC: 30459	AceView: LOC283985	Ensembl:ENSG00000172782	euGenes: HUgn283985
ECgene: FADS6	H-InvDB: FADS6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for FADS6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FADS6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FADS6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FADS6		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Novus for antibodies for FADS6

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FADS6 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for FADS6

Summaries
for FADS6

Genomic Location
for FADS6

Proteins
for FADS6

Protein Domains/
Families
for FADS6

Gene Function
for FADS6

Pathways & Interactions
for FADS6

Drugs & Compounds
for FADS6

Transcripts
for FADS6

Expression
for FADS6

Orthologs
for FADS6

Paralogs
for FADS6

SNPs/Variants
for FADS6

Disorders & Mutations
for FADS6

Medical News
for FADS6

Publications
for FADS6

Search for FADS6

Genome Databases showing FADS6

Other Databases showing FADS6

Specialized Databases showing FADS6

Licensable Technologies
for FADS6

Services
for FADS6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FADS6 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor FADS6

Summariesfor FADS6

Genomic Locationfor FADS6

Proteinsfor FADS6

Protein Domains/Familiesfor FADS6

Gene Functionfor FADS6

Pathways & Interactionsfor FADS6

Drugs & Compoundsfor FADS6

Transcriptsfor FADS6

Expression for FADS6

Orthologsfor FADS6

Paralogsfor FADS6

SNPs/Variantsfor FADS6

Disorders & Mutationsfor FADS6

Medical Newsfor FADS6

Publicationsfor FADS6

Search for FADS6

Genome Databases showing FADS6

Other Databases showing FADS6

Specialized Databases showing FADS6

Licensable Technologiesfor FADS6

Servicesfor FADS6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FADS6

Summaries
for FADS6

Genomic Location
for FADS6

Proteins
for FADS6

Protein Domains/
Families
for FADS6

Gene Function
for FADS6

Pathways & Interactions
for FADS6

Drugs & Compounds
for FADS6

Transcripts
for FADS6

Expression
for FADS6

Orthologs
for FADS6

Paralogs
for FADS6

SNPs/Variants
for FADS6

Disorders & Mutations
for FADS6

Medical News
for FADS6

Publications
for FADS6

Licensable Technologies
for FADS6

Services
for FADS6