FADS6 Gene
protein-coding GIFtS: 40
GCID: GC17M072873
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fatty acid desaturase 6(Previous names: fatty acid desaturase domain family, member 6 )
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Aliases
for FADS6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fatty Acid Desaturase 61 2 | | Fatty Acid Desaturase Domain Family, Member 61 2 | | EC 1.14.19.-3 |
Export aliases for FADS6 gene to outside databasesPrevious GC identifers: GC17M070386 GC17M068283 |
Summaries
for FADS6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FADS6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FADS6 gene promoter:
c-Fos AhR Egr-3 Bach1 AP-1 NRSF form 1 NRSF form 2 Gfi-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for FADS6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FADS6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1FADS6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M072873: view genomic region
(about GC identifiers)
Start:
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72,873,428 bp from pter |
End:
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72,889,708 bp from pter |
Size:
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16,281 bases |
Orientation:
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minus strand |
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Proteins
for FADS6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FADS6_HUMAN, Q8N9I5 (See
protein sequence)Recommended Name: Fatty acid desaturase 6 Size: 356 amino acids; 40447 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC04349.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains a duplication ofthe repeated 'MEPTEP' sequence. It is unclear whether such duplication is due to a sequencing error or a polymorphism;
Secondary accessions: Q17RQ7 Q6XYE1Alternative splicing: 2 isoforms: Q8N9I5-1 Q8N9I5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FADS6: NX_Q8N9I5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9I5
FADS6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_835229.2
ENSEMBL proteins: ENSP00000307821 ENSP00000464267
Human Recombinant Protein Products for FADS6:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FADS6 for ontologies About GeneDecksing
FADS6 Antibody Products:
Assay Products for FADS6: |
Protein
Domains /
Families
for FADS6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FADS6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N9I5ProtoNet protein and cluster: Q8N9I5 UniProtKB/Swiss-Prot: FADS6_HUMAN, Q8N9I5Similarity: Belongs to the fatty acid desaturase family |
Function
for FADS6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 1.14.19.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016491 | oxidoreductase activity |
IEA | -- |
FADS6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for FADS6:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FADS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FADS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FADS6 (NM_178128) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FADS6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FADS6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADS6 |
|
Pathways & Interactions
for FADS6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Biosynthesis of unsaturated fatty acids | |
1  BioSystems Pathway for FADS6
UniProtKB/Swiss-Prot: FADS6_HUMAN, Q8N9I5Pathway: Lipid metabolism; fatty acid metabolismInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FADS6
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for FADS6 (ENSP000003078214) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006633 | fatty acid biosynthetic process |
IEA | -- |
FADS6 for ontologies About GeneDecksing
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Drugs & Compounds
for FADS6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FADS6
Search CenterWatch for drugs/clinical trials and news about FADS6
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Transcripts
for FADS6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FADS6 gene: NM_178128.3 Unigene Cluster for FADS6: Fatty acid desaturase domain family, member 6 Hs.448845 [show with all ESTs]Unigene Representative Sequence: AY2039293 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310226(uc010wrn.1 uc002jmd.1) ENST00000413142 ENST00000579663
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FADS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FADS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FADS6 (NM_178128) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FADS6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FADS6 |
Additional cDNA sequence: AK094411.1 AK293720.1 AY203929.1 BC117230.1 3 DOTS entries: DT.99930267 DT.120974581 DT.91652998 4 AceView cDNA sequences: BG696484 AK094411 AY203929 NM_178128
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FADS6 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for FADS6
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Expression
for FADS6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FADS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FADS6 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.448845
SABiosciences Custom PCR Arrays for FADS6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FADS6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FADS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FADS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FADS6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADS6 |
Orthologs
for FADS6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for FADS6 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for FADS6 (if available)
TreeFam Gene Tree for FADS6 (if available) |
Paralogs
for FADS6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FADS6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FADS6 (72873428 - 72889708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FADS6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FADS6 |
|
Disorders
/ Diseases
for FADS6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FADS6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FADS6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FADS6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Sequence variation and genomic organization of fatty acid desaturase-2 (fad2) and fatty acid desaturase-6 (fad6) cDNAs in maize. (PubMed id 12677402)9 Mikkilineni V. and Rocheford T.R. (2003)
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External Searches for FADS6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FADS6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FADS6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FADS6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FADS6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FADS6 gene:
Search GeneIP for patents involving FADS6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FADS6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FADS6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FADS6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FADS6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FADS6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FADS6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FADS6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FADS6 | | OriGene Custom Protein Services for FADS6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FADS6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FADS6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FADS6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FADS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FADS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FADS6 |
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 |  |  |  | |
| | | | Search Tocris compounds for FADS6 |
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 | | | FADS6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADS6 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FADS6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FADS6 |
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