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Aliases for FADS6 Gene

Aliases for FADS6 Gene

  • Fatty Acid Desaturase 6 2 3 5
  • Fatty Acid Desaturase Domain Family, Member 6 2 3
  • EC 1.14.19.- 4
  • FP18279 3

External Ids for FADS6 Gene

Previous GeneCards Identifiers for FADS6 Gene

  • GC17M070386
  • GC17M072873
  • GC17M068283

Summaries for FADS6 Gene

GeneCards Summary for FADS6 Gene

FADS6 (Fatty Acid Desaturase 6) is a Protein Coding gene. Among its related pathways are oleate biosynthesis. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FADS6 Gene

Genomics for FADS6 Gene

Regulatory Elements for FADS6 Gene

Enhancers for FADS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G075010 1.8 FANTOM5 ENCODE dbSUPER 12.2 -118.4 -118392 3.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 HID1 KCTD2 CDR2L FADS6 ATP5H MRPL58 RAB37 GRIN2C ARMC7 SUMO2
GH17G074688 1.5 FANTOM5 Ensembl ENCODE 10.6 +204.0 203970 3.1 HDGF SIN3A BMI1 FEZF1 DNMT3B ZNF48 ZNF121 ZNF207 RELB IKZF2 CD300LF CD300E TMEM104 CD300LD CD300C CD300LB FADS6 NAT9 GRIN2C CD300A
GH17G074785 1.4 FANTOM5 Ensembl ENCODE 11 +107.5 107478 1.9 TBP ELF3 FOXA2 ARID4B DMAP1 RAD21 THAP11 MIXL1 SP5 CEBPB RAB37 CD300E SLC9A3R1 GRIN2C FADS6 CD300LB TMEM104 CD300LF CD300C CD300A
GH17G074840 1.4 Ensembl ENCODE dbSUPER 10.9 +51.6 51566 3.4 FOXA2 RB1 ARID4B RAD21 ZNF121 GLIS2 ZNF143 ZNF263 REST ZNF341 GRIN2C FDXR FADS6 PIR37943 PIR51683
GH17G074989 1.4 Ensembl ENCODE dbSUPER 10.6 -98.2 -98150 4.1 SIN3A ARID4B FEZF1 ZNF2 ZNF48 ZNF121 ZNF143 REST MIER3 KDM1A HID1 RNU6-362P OTOP3 KCTD2 ATP5H FADS6 MRPL58 CDR2L GC17M074998
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FADS6 on UCSC Golden Path with GeneCards custom track

Genomic Location for FADS6 Gene

Chromosome:
17
Start:
74,876,776 bp from pter
End:
74,893,811 bp from pter
Size:
17,036 bases
Orientation:
Minus strand

Genomic View for FADS6 Gene

Genes around FADS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FADS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FADS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADS6 Gene

Proteins for FADS6 Gene

  • Protein details for FADS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9I5-FADS6_HUMAN
    Recommended name:
    Fatty acid desaturase 6
    Protein Accession:
    Q8N9I5
    Secondary Accessions:
    • Q17RQ7
    • Q6XYE1

    Protein attributes for FADS6 Gene

    Size:
    356 amino acids
    Molecular mass:
    40447 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04349.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains a duplication of the repeated MEPTEP sequence. It is unclear whether such duplication is due to a sequencing error or a polymorphism.; Evidence={ECO:0000305};

    Alternative splice isoforms for FADS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FADS6 Gene

Post-translational modifications for FADS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FADS6 Gene

No data available for DME Specific Peptides for FADS6 Gene

Domains & Families for FADS6 Gene

Gene Families for FADS6 Gene

Protein Domains for FADS6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N9I5

UniProtKB/Swiss-Prot:

FADS6_HUMAN :
  • Belongs to the fatty acid desaturase type 1 family.
Family:
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with FADS6: view

Function for FADS6 Gene

Enzyme Numbers (IUBMB) for FADS6 Gene

Gene Ontology (GO) - Molecular Function for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with FADS6: view
genes like me logo Genes that share phenotypes with FADS6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FADS6

CRISPR Products

miRNA for FADS6 Gene

miRTarBase miRNAs that target FADS6

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FADS6 Gene

Localization for FADS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FADS6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FADS6 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FADS6: view

Pathways & Interactions for FADS6 Gene

SuperPathways for FADS6 Gene

SuperPathway Contained pathways
1 oleate biosynthesis
genes like me logo Genes that share pathways with FADS6: view

Pathways by source for FADS6 Gene

1 BioSystems pathway for FADS6 Gene

UniProtKB/Swiss-Prot Q8N9I5-FADS6_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Interacting Proteins for FADS6 Gene

Selected Interacting proteins: Q8N9I5-FADS6_HUMAN for FADS6 Gene via IID

Symbol External ID(s) Details
RCHY1

Gene Ontology (GO) - Biological Process for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FADS6: view

No data available for SIGNOR curated interactions for FADS6 Gene

Drugs & Compounds for FADS6 Gene

No Compound Related Data Available

Transcripts for FADS6 Gene

mRNA/cDNA for FADS6 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FADS6 Gene

Fatty acid desaturase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FADS6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for FADS6 Gene

GeneLoc Exon Structure for
FADS6
ECgene alternative splicing isoforms for
FADS6

Expression for FADS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FADS6 Gene

mRNA differential expression in normal tissues according to GTEx for FADS6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.4), Small Intestine - Terminal Ileum (x4.9), and Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for FADS6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FADS6 Gene



Protein tissue co-expression partners for FADS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FADS6 Gene:

FADS6

SOURCE GeneReport for Unigene cluster for FADS6 Gene:

Hs.448845

Evidence on tissue expression from TISSUES for FADS6 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FADS6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FADS6 Gene

Orthologs for FADS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FADS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FADS6 34 35
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia FADS6 34 35
  • 87.57 (n)
dog
(Canis familiaris)
Mammalia FADS6 34 35
  • 84.71 (n)
mouse
(Mus musculus)
Mammalia Fads6 34 16 35
  • 82.35 (n)
rat
(Rattus norvegicus)
Mammalia Fads6 34
  • 81.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FADS6 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FADS6 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FADS6 34 35
  • 70.72 (n)
lizard
(Anolis carolinensis)
Reptilia FADS6 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fads6 34
  • 60.48 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538024 34
  • 62.18 (n)
CABZ01073954.1 35
  • 52 (a)
OneToOne
Species where no ortholog for FADS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FADS6 Gene

ENSEMBL:
Gene Tree for FADS6 (if available)
TreeFam:
Gene Tree for FADS6 (if available)

Paralogs for FADS6 Gene

No data available for Paralogs for FADS6 Gene

Variants for FADS6 Gene

Sequence variations from dbSNP and Humsavar for FADS6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000064780 -- 74,875,569(+) CCATA(A/C)CCCAG utr-variant-3-prime
rs1000190761 -- 74,887,236(+) ACACC(A/G)CCACA intron-variant
rs1000192575 -- 74,892,434(+) ATGCA(C/T)AGCTG intron-variant
rs1000194309 -- 74,894,791(+) TGATT(A/C)CTTTT upstream-variant-2KB
rs1000422573 -- 74,892,417(+) CCTGC(C/T)CCCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FADS6 Gene

Variant ID Type Subtype PubMed ID
esv2662692 CNV deletion 23128226
esv2670185 CNV deletion 23128226
esv2677388 CNV deletion 23128226
esv3429588 CNV insertion 20981092
esv3554779 CNV deletion 23714750
esv3582911 CNV loss 25503493
esv3641248 CNV loss 21293372
esv3641249 CNV loss 21293372
esv3641250 CNV loss 21293372
esv3641251 CNV loss 21293372
nsv1142904 CNV tandem duplication 24896259
nsv457909 CNV gain 19166990
nsv518292 CNV loss 19592680
nsv576026 CNV gain 21841781
nsv833540 CNV loss 17160897
nsv952367 CNV deletion 24416366

Variation tolerance for FADS6 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FADS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FADS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FADS6 Gene

Disorders for FADS6 Gene

Relevant External Links for FADS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FADS6

No disorders were found for FADS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FADS6 Gene

Publications for FADS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4 64
  5. Sequence variation and genomic organization of fatty acid desaturase-2 (fad2) and fatty acid desaturase-6 (fad6) cDNAs in maize. (PMID: 12677402) Mikkilineni V. … Rocheford T.R. (Theor. Appl. Genet. 2003) 22 64

Products for FADS6 Gene

Sources for FADS6 Gene

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