Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FADS6 Gene

Aliases for FADS6 Gene

  • Fatty Acid Desaturase 6 2 3
  • Fatty Acid Desaturase Domain Family, Member 6 2 3
  • EC 1.14.19.- 4
  • FP18279 3

External Ids for FADS6 Gene

Previous GeneCards Identifiers for FADS6 Gene

  • GC17M070386
  • GC17M072873
  • GC17M068283

Summaries for FADS6 Gene

GeneCards Summary for FADS6 Gene

FADS6 (Fatty Acid Desaturase 6) is a Protein Coding gene. Among its related pathways are Biosynthesis of unsaturated fatty acids. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FADS6 Gene

Genomics for FADS6 Gene

Regulatory Elements for FADS6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FADS6 Gene

74,876,786 bp from pter
74,893,805 bp from pter
17,020 bases
Minus strand

Genomic View for FADS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FADS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADS6 Gene

Proteins for FADS6 Gene

  • Protein details for FADS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fatty acid desaturase 6
    Protein Accession:
    Secondary Accessions:
    • Q17RQ7
    • Q6XYE1

    Protein attributes for FADS6 Gene

    356 amino acids
    Molecular mass:
    40447 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04349.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains a duplication of the repeated MEPTEP sequence. It is unclear whether such duplication is due to a sequencing error or a polymorphism.; Evidence={ECO:0000305};

    Alternative splice isoforms for FADS6 Gene


neXtProt entry for FADS6 Gene

Proteomics data for FADS6 Gene at MOPED

Post-translational modifications for FADS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FADS6 Gene

No data available for DME Specific Peptides for FADS6 Gene

Domains for FADS6 Gene

Gene Families for FADS6 Gene

  • FADS :Fatty acid desaturases

Protein Domains for FADS6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q8N9I5
  • Belongs to the fatty acid desaturase family.
genes like me logo Genes that share domains with FADS6: view

Function for FADS6 Gene

Enzyme Numbers (IUBMB) for FADS6 Gene

Gene Ontology (GO) - Molecular Function for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with FADS6: view

Phenotypes for FADS6 Gene

genes like me logo Genes that share phenotypes with FADS6: view

Animal Model Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FADS6 Gene

Localization for FADS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FADS6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FADS6 Gene COMPARTMENTS Subcellular localization image for FADS6 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FADS6: view

Pathways for FADS6 Gene

genes like me logo Genes that share pathways with FADS6: view

Pathways by source for FADS6 Gene

1 BioSystems pathway for FADS6 Gene

UniProtKB/Swiss-Prot Q8N9I5-FADS6_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism

Interacting Proteins for FADS6 Gene

Gene Ontology (GO) - Biological Process for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FADS6: view

Transcripts for FADS6 Gene

mRNA/cDNA for FADS6 Gene

(4) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FADS6 Gene

Fatty acid desaturase 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FADS6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FADS6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP2: -

Relevant External Links for FADS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FADS6 Gene

mRNA expression in normal human tissues for FADS6 Gene

mRNA differential expression in normal tissues according to GTEx for FADS6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.4), Small Intestine - Terminal Ileum (4.9), and Brain - Cerebellum (4.9).

Protein differential expression in normal tissues for FADS6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FADS6 Gene

SOURCE GeneReport for Unigene cluster for FADS6 Gene Hs.448845

genes like me logo Genes that share expressions with FADS6: view

Expression partners for FADS6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FADS6 Gene

Orthologs for FADS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FADS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FADS6 35
  • 87.57 (n)
  • 86.09 (a)
FADS6 36
  • 85 (a)
(Canis familiaris)
Mammalia FADS6 35
  • 84.71 (n)
  • 83.14 (a)
FADS6 36
  • 84 (a)
(Mus musculus)
Mammalia Fads6 35
  • 82.35 (n)
  • 81.07 (a)
Fads6 16
Fads6 36
  • 80 (a)
(Pan troglodytes)
Mammalia FADS6 35
  • 98.95 (n)
  • 98.85 (a)
FADS6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fads6 35
  • 81.76 (n)
  • 80.47 (a)
(Monodelphis domestica)
Mammalia FADS6 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia FADS6 36
  • 73 (a)
(Gallus gallus)
Aves FADS6 35
  • 70.72 (n)
  • 68.84 (a)
FADS6 36
  • 57 (a)
(Anolis carolinensis)
Reptilia FADS6 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fads6 35
  • 60.48 (n)
  • 53.33 (a)
(Danio rerio)
Actinopterygii LOC100538024 35
  • 62.18 (n)
  • 55.99 (a)
CABZ01073954.1 36
  • 52 (a)
Species with no ortholog for FADS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FADS6 Gene

Gene Tree for FADS6 (if available)
Gene Tree for FADS6 (if available)

Paralogs for FADS6 Gene

No data available for Paralogs for FADS6 Gene

Variants for FADS6 Gene

Sequence variations from dbSNP and Humsavar for FADS6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs485306 -- 74,881,730(+) agact(C/T)tgaaa intron-variant
rs489152 -- 74,892,709(+) GGAAG(A/G)AGACG intron-variant
rs490985 -- 74,892,904(+) TCTCC(A/C)GTGCG intron-variant
rs511421 -- 74,891,332(+) CGCGC(C/G)CAGCC intron-variant
rs511645 -- 74,891,410(+) GTCCA(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FADS6 Gene

Variant ID Type Subtype PubMed ID
nsv908743 CNV Loss 21882294
nsv518292 CNV Loss 19592680
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
esv2662692 CNV Deletion 23128226
esv2677388 CNV Deletion 23128226
esv2670185 CNV Deletion 23128226
nsv457909 CNV Gain 19166990

Relevant External Links for FADS6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FADS6 Gene

Disorders for FADS6 Gene

No disorders were found for FADS6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FADS6 Gene

Publications for FADS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4
  5. Sequence variation and genomic organization of fatty acid desaturase-2 (fad2) and fatty acid desaturase-6 (fad6) cDNAs in maize. (PMID: 12677402) Mikkilineni V. … Rocheford T.R. (Theor. Appl. Genet. 2003) 23

Products for FADS6 Gene

Sources for FADS6 Gene

Back to Top