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Aliases for FADS6 Gene

Aliases for FADS6 Gene

  • Fatty Acid Desaturase 6 2 3 5
  • Fatty Acid Desaturase Domain Family, Member 6 2 3
  • EC 1.14.19.- 4
  • FP18279 3

External Ids for FADS6 Gene

Previous GeneCards Identifiers for FADS6 Gene

  • GC17M070386
  • GC17M072873
  • GC17M068283

Summaries for FADS6 Gene

GeneCards Summary for FADS6 Gene

FADS6 (Fatty Acid Desaturase 6) is a Protein Coding gene. Among its related pathways are oleate biosynthesis. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FADS6 Gene

Genomics for FADS6 Gene

Regulatory Elements for FADS6 Gene

Enhancers for FADS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075010 1.5 FANTOM5 ENCODE 12.2 -118.4 -118392 3.7 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UNK HID1 ENSG00000267801 ENSG00000266980 ENSG00000264829 NUP85 KCTD2 CDR2L NT5C HID1-AS1
GH17F074687 1.7 FANTOM5 Ensembl ENCODE 10.6 +204.4 204410 4.0 HDGF ARID4B SIN3A FEZF1 FOS SP5 MXD4 REST TBX21 KAT8 CD300LF CD300E TMEM104 CD300LD SUMO2 CD300C CD300LB FADS6 NAT9 GRIN2C
GH17F074785 1.4 FANTOM5 Ensembl ENCODE 11 +107.5 107478 1.9 TBP ELF3 SOX13 DRAP1 CTCF SAP130 ARID4B DMAP1 ZNF644 RAD21 RAB37 CD300E SLC9A3R1 MIR3615 GRIN2C FADS6 CD300LB TMEM104 CD300LF CD300C
GH17F074812 1 FANTOM5 Ensembl ENCODE 14.4 +81.1 81104 1.4 ZNF121 ZIC2 GRIN2C FADS6 CD300E KIF19 KCTD2 RAB37 PIR51683 PIR37943
GH17F074790 1.2 Ensembl ENCODE 11.3 +102.7 102748 1.7 ATF1 PKNOX1 CREB3L1 MLX ARID4B SIN3A ZNF48 ZNF2 ZNF143 KLF7 RAB37 GRIN2C MIR3615 SLC9A3R1 FDXR FADS6 OTOP3 CD300LF TMEM104 PIR51683
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FADS6 on UCSC Golden Path with GeneCards custom track

Genomic Location for FADS6 Gene

74,876,776 bp from pter
74,893,811 bp from pter
17,036 bases
Minus strand

Genomic View for FADS6 Gene

Genes around FADS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FADS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FADS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADS6 Gene

Proteins for FADS6 Gene

  • Protein details for FADS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fatty acid desaturase 6
    Protein Accession:
    Secondary Accessions:
    • Q17RQ7
    • Q6XYE1

    Protein attributes for FADS6 Gene

    356 amino acids
    Molecular mass:
    40447 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04349.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains a duplication of the repeated MEPTEP sequence. It is unclear whether such duplication is due to a sequencing error or a polymorphism.; Evidence={ECO:0000305};

    Alternative splice isoforms for FADS6 Gene


neXtProt entry for FADS6 Gene

Post-translational modifications for FADS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FADS6 Gene

No data available for DME Specific Peptides for FADS6 Gene

Domains & Families for FADS6 Gene

Gene Families for FADS6 Gene

Protein Domains for FADS6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fatty acid desaturase type 1 family.
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with FADS6: view

Function for FADS6 Gene

Enzyme Numbers (IUBMB) for FADS6 Gene

Gene Ontology (GO) - Molecular Function for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with FADS6: view
genes like me logo Genes that share phenotypes with FADS6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FADS6

miRNA for FADS6 Gene

miRTarBase miRNAs that target FADS6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FADS6 Gene

Localization for FADS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FADS6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FADS6 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FADS6: view

Pathways & Interactions for FADS6 Gene

SuperPathways for FADS6 Gene

SuperPathway Contained pathways
1 oleate biosynthesis
genes like me logo Genes that share pathways with FADS6: view

Pathways by source for FADS6 Gene

1 BioSystems pathway for FADS6 Gene

UniProtKB/Swiss-Prot Q8N9I5-FADS6_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Interacting Proteins for FADS6 Gene

Selected Interacting proteins: Q8N9I5-FADS6_HUMAN for FADS6 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FADS6: view

No data available for SIGNOR curated interactions for FADS6 Gene

Transcripts for FADS6 Gene

mRNA/cDNA for FADS6 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FADS6 Gene

Fatty acid desaturase 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FADS6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP2: -

Relevant External Links for FADS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FADS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FADS6 Gene

mRNA differential expression in normal tissues according to GTEx for FADS6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.4), Small Intestine - Terminal Ileum (x4.9), and Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for FADS6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FADS6 Gene

Protein tissue co-expression partners for FADS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FADS6 Gene:


SOURCE GeneReport for Unigene cluster for FADS6 Gene:

genes like me logo Genes that share expression patterns with FADS6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FADS6 Gene

Orthologs for FADS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FADS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FADS6 34 35
  • 98.95 (n)
(Bos Taurus)
Mammalia FADS6 34 35
  • 87.57 (n)
(Canis familiaris)
Mammalia FADS6 34 35
  • 84.71 (n)
(Mus musculus)
Mammalia Fads6 34 16 35
  • 82.35 (n)
(Rattus norvegicus)
Mammalia Fads6 34
  • 81.76 (n)
(Ornithorhynchus anatinus)
Mammalia FADS6 35
  • 73 (a)
(Monodelphis domestica)
Mammalia FADS6 35
  • 68 (a)
(Gallus gallus)
Aves FADS6 34 35
  • 70.72 (n)
(Anolis carolinensis)
Reptilia FADS6 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fads6 34
  • 60.48 (n)
(Danio rerio)
Actinopterygii LOC100538024 34
  • 62.18 (n)
CABZ01073954.1 35
  • 52 (a)
Species where no ortholog for FADS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FADS6 Gene

Gene Tree for FADS6 (if available)
Gene Tree for FADS6 (if available)

Paralogs for FADS6 Gene

No data available for Paralogs for FADS6 Gene

Variants for FADS6 Gene

Sequence variations from dbSNP and Humsavar for FADS6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11077766 -- 74,881,969(+) gctcc(C/T)ctgta intron-variant
rs111242628 -- 74,886,195(+) GATCC(C/T)GCCAC intron-variant
rs111242700 -- 74,894,539(+) CAGCC(C/T)AGGCC upstream-variant-2KB
rs111322037 -- 74,881,438(+) CAAGC(C/T)TATAA intron-variant
rs111400905 -- 74,889,066(+) CGGAG(C/G)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FADS6 Gene

Variant ID Type Subtype PubMed ID
nsv518292 CNV loss 19592680
nsv576026 CNV gain 21841781
nsv833540 CNV loss 17160897
nsv952367 CNV deletion 24416366
nsv457909 CNV gain 19166990
nsv1142904 CNV tandem duplication 24896259
esv3641251 CNV loss 21293372
esv3641250 CNV loss 21293372
esv3641249 CNV loss 21293372
esv3641248 CNV loss 21293372
esv3582911 CNV loss 25503493
esv3554779 CNV deletion 23714750
esv3429588 CNV insertion 20981092
esv2677388 CNV deletion 23128226
esv2670185 CNV deletion 23128226
esv2662692 CNV deletion 23128226

Variation tolerance for FADS6 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FADS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FADS6 Gene

Disorders for FADS6 Gene

Relevant External Links for FADS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FADS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FADS6 Gene

Publications for FADS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 4 64
  5. Sequence variation and genomic organization of fatty acid desaturase-2 (fad2) and fatty acid desaturase-6 (fad6) cDNAs in maize. (PMID: 12677402) Mikkilineni V. … Rocheford T.R. (Theor. Appl. Genet. 2003) 22 64

Products for FADS6 Gene

Sources for FADS6 Gene

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