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FADS3 Gene

protein-coding   GIFtS: 55
GCID: GC11M061640

Fatty Acid Desaturase 3


(Previous symbol: LLCDL3)
  Search for FADS3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Desaturase 31 2     Delta-9 Fatty Acid Desaturase2
LLCDL31 2     Linoleoyl-CoA Desaturase (Delta-9-Desaturase)-Like 32
delta-9-desaturase1 2     EC 1.14.19.-3
Cytochrome B5-Related Protein2 3     EC 1.14.198
CYB5RP2 3     

External Ids:    HGNC: 35761   Entrez Gene: 39952   Ensembl: ENSG000002219687   OMIM: 6061505   UniProtKB: Q9Y5Q03   

Export aliases for FADS3 gene to outside databases

Previous GC identifers: GC11M064126 GC11M063216 GC11M061891 GC11M061416 GC11M061324 GC11M061397 GC11M057969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FADS3 Gene:
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes
regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the
fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like
domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by
conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this
cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron
organization. (provided by RefSeq, Jul 2008)

GeneCards Summary for FADS3 Gene:
FADS3 (fatty acid desaturase 3) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water and iron ion binding. An important paralog of this gene is FADS2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FADS3 gene promoter:
         Max1   AML1a   Olf-1   MyoD   STAT5A   AP-4   E47   c-Ets-1   AREB6   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFADS3 promoter sequence
   Search Chromatin IP Primers for FADS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FADS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13.1   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12-q13.1

FADS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FADS3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061640:  view genomic region     (about GC identifiers)

Start:
61,640,991 bp from pter      End:
61,659,523 bp from pter
Size:
18,533 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FADS3_HUMAN, Q9Y5Q0 (See protein sequence)
Recommended Name: Fatty acid desaturase 3  
Size: 445 amino acids; 51145 Da
Sequence caution: Sequence=AAC23396.1; Type=Erroneous gene model prediction;
Secondary accessions: O60426

Explore the universe of human proteins at neXtProt for FADS3: NX_Q9Y5Q0

Explore proteomics data for FADS3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys225
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FADS3 (Q9Y5Q0) (see all 9)
     TQMNHIP  LQHDLGH  EDATDAF  DKWLVIER 


    See FADS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068373.1  
    ENSEMBL proteins: 
     ENSP00000431533   ENSP00000278829   ENSP00000435597   ENSP00000432012   ENSP00000432206  
     ENSP00000436890   ENSP00000434551   ENSP00000439308  

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    Cloud-Clone Corp. Proteins for FADS3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FADS: Fatty acid desaturases

    3 InterPro protein domains:
     IPR001199 Cyt_B5-like_heme/steroid-bd
     IPR005804 Fatty_acid_desaturase-1
     IPR012171 Fatty_acid/sphinglp_desaturase

    Graphical View of Domain Structure for InterPro Entry Q9Y5Q0

    ProtoNet protein and cluster: Q9Y5Q0

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: FADS3_HUMAN, Q9Y5Q0
    Domain: The histidine box domains may contain the active site and/or be involved in metal ion binding
    Similarity: Belongs to the fatty acid desaturase family
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    Find genes that share domains with FADS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 1.14.19.-1 EC 1.14.192

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005506iron ion binding IEA--
    GO:0016717oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA--
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with FADS3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FADS3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FADS3
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    miRNA
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    miRTarBase miRNAs that target FADS3:
    hsa-mir-98-5p (MIRT027418)

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    2 qRT-PCR Assays for microRNAs that regulate FADS3:
    hsa-miR-3163 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidFADS3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FADS3_HUMAN, Q9Y5Q0: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane NAS10860662
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FADS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FADS3 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
    alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
    alpha-linolenic acid (ALA) metabolism0.00
    Linoleic acid (LA) metabolism0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FADS3
    Interactions:

        Search GeneGlobe Interaction Network for FADS3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FADS3 (ENSP000002788294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ATP5EENSP000002439974STRING: ENSP00000243997
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process ----
    GO:0006636unsaturated fatty acid biosynthetic process NAS10860662
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with FADS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FADS3

    1 HMDB Compound for FADS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FADS3 gene: 
    NM_021727.4  

    Unigene Cluster for FADS3:

    Fatty acid desaturase 3
    Hs.21765  [show with all ESTs]
    Unigene Representative Sequence: AB209356
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527697 ENST00000533676 ENST00000278829(uc001nsm.3) ENST00000529404
    ENST00000527379 ENST00000525094 ENST00000525588 ENST00000531956 ENST00000534223
    ENST00000526294 ENST00000414624 ENST00000534426 ENST00000529525 ENST00000540820

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FADS3:
    hsa-miR-3163 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidFADS3 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FADS3
      QuantiTect SYBR Green Assays in human, mouse, rat FADS3
      QuantiFast Probe-based Assays in human, mouse, rat FADS3

    Additional mRNA sequence: 

    AB209356.1 AF084560.1 AF134404.1 AK091608.1 AK295473.1 AK310523.1 BC004901.2 

    12 DOTS entries:

    DT.97844554  DT.100684064  DT.80101230  DT.100806848  DT.100806846  DT.95286634  DT.100806844  DT.100667587 
    DT.100806847  DT.120748851  DT.75194277  DT.95201368 

    Selected AceView cDNA sequences (see all 40):

    CR608795 CR618275 CR607573 NM_021727 AK091608 BE763432 AX747091 M91491 
    BE676674 CD630890 CD630888 BX377520 BX423436 AI806997 BC004901 AI394672 
    BF732840 AF134404 AF084560 BE763399 BX455254 BF917935 AI682885 BX091307 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FADS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTCAGC
    FADS3 Expression
    About this image


    FADS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Kidney (Urinary System)
             S-shaped Body
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    FADS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FADS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21765

    UniProtKB/Swiss-Prot: FADS3_HUMAN, Q9Y5Q0
    Tissue specificity: Has been found in heart, liver, lung, uterus, and brainstem

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FADS3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fads31 , 5 fatty acid desaturase 31, 5 87.94(n)1
    90.11(a)1
      19 (6.33 cM)5
    605271  NM_021890.31  NP_068690.31 
     100415485 
    chicken
    (Gallus gallus)
    Aves FADS26
    Gallus gallus fatty acid desaturase 2 (FADS2), mRN...
    61(a)
    1 → many
    5(16094681-16111781) ENSGALG00000007178
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    GL343235.1(2092437-2125756)
    zebrafish
    (Danio rerio)
    Actinopterygii fads26
    fatty acid desaturase 2
    54(a)
    1 → many
    25(4189905-4205135) ENSDARG00000019532
    worm
    (Caenorhabditis elegans)
    Secernentea fat-36
    fat-46
    Protein FAT-4, isoform a
    25(a)
    22(a)
    many ↔ many
    many ↔ many
    IV(9803026-9806121) WBGene00001395
    IV(9799429-9802231) WBGene00001396


    ENSEMBL Gene Tree for FADS3 (if available)
    TreeFam Gene Tree for FADS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FADS3 gene
    FADS22  FADS12  
    4 SIMAP similar genes for FADS3 using alignment to 8 protein entries:     FADS3_HUMAN (see all proteins):
    FADS2    FADS1    FADS2P1    DKFZp686M0619

    Find genes that share paralogs with FADS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FADS3 (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454037701,2
    --61640498(+) GAGATC/TGACGT 1 -- ds50010--------
    rs65916641,2
    C,F,A,H--61640521(+) CCACCA/GGGCAC 1 -- ds500114Minor allele frequency- G:0.12NA WA CSA EA 377
    rs1816879281,2
    --61640542(+) ACCACA/CACTGG 1 -- ds50010--------
    rs1492016761,2
    --61640659(+) ACAACC/TGTCTT 1 -- ds50010--------
    rs1450925011,2
    --61640754(+) GAAGCA/GTCAAG 1 -- ds50010--------
    rs1857165971,2
    C--61640919(+) ATGGCC/TGAGGG 1 -- ds50010--------
    rs65916651,2
    C,H--61641211(+) GGGTGG/AGGGTA 1 -- ut3110Minor allele frequency- A:0.00NA WA EA 374
    rs753064421,2
    C--61641396(+) CCTAAC/TACCCC 1 -- int14Minor allele frequency- T:0.15NA CSA WA 243
    rs1379433851,2
    --61641407(+) TGTATA/CCCCCA 1 -- int10--------
    rs1744501,2
    C,F,A,H--61641542(-) CGTCAC/ACCCGG 1 -- int123Minor allele frequency- A:0.46NS EA NA WA CSA 2344

    HapMap Linkage Disequilibrium report for FADS3 (61640991 - 61659523 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FADS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv217e199CNV Deletion23128226
    nsv528697CNV Loss19592680
    nsv897613CNV Loss21882294
    nsv897616CNV Loss21882294
    nsv897614CNV Loss21882294
    nsv897615CNV Loss21882294
    nsv468585CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FADS3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606150    OMIM disorders: --


    Find genes that share disorders with FADS3           About GenesLikeMe

    Genetic Association Database (GAD): FADS3
    Human Genome Epidemiology (HuGE) Navigator: FADS3 (14 documents)

    Export disorders for FADS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FADS3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with FADS3)
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    1. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. (PubMed id 10860662)1, 2, 9 Marquardt A.... Weber B.H. (Genomics 2000)
    2. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. (PubMed id 19148276)1, 4, 9 Tanaka T....Ferrucci L. (PLoS Genet. 2009)
    3. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PubMed id 21829377)1, 4 Lemaitre R.N....Steffen L.M. (PLoS Genet. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    6. Genetic determinants of circulating sphingolipid concentrations in European populations. (PubMed id 19798445)1, 4 Hicks A.A....Campbell H. (PLoS Genet. 2009)
    7. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (Nat. Genet. 2009)
    8. The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues. (PubMed id 19752397)1, 9 PAcdrono F....Legrand P. (J. Lipid Res. 2010)
    9. A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. (PubMed id 19750004)1, 9 Plaisier C.L....Pajukanta P. (PLoS Genet. 2009)
    10. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3995 HGNC: 3576 AceView: FADS3 Ensembl:ENSG00000221968 euGenes: HUgn3995
    ECgene: FADS3 H-InvDB: FADS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FADS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FADS3 gene:
    Search GeneIP for patents involving FADS3

    GeneCards and IP:
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