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Aliases for FADS3 Gene

Aliases for FADS3 Gene

  • Fatty Acid Desaturase 3 2 3
  • Cytochrome B5-Related Protein 3 4
  • Delta-9-Desaturase 2 3
  • CYB5RP 3 4
  • Linoleoyl-CoA Desaturase (Delta-9-Desaturase)-Like 3 3
  • Delta-9 Fatty Acid Desaturase 3
  • EC 1.14.19.- 4
  • EC 1.14.19 64
  • LLCDL3 3

External Ids for FADS3 Gene

Previous Symbols for FADS3 Gene

  • LLCDL3

Summaries for FADS3 Gene

Entrez Gene Summary for FADS3 Gene

  • The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]

GeneCards Summary for FADS3 Gene

FADS3 (Fatty Acid Desaturase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. An important paralog of this gene is FADS1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FADS3 Gene

Genomics for FADS3 Gene

Genomic Location for FADS3 Gene

Start:
61,873,519 bp from pter
End:
61,892,051 bp from pter
Size:
18,533 bases
Orientation:
Minus strand

Genomic View for FADS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FADS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADS3 Gene

Regulatory Elements for FADS3 Gene

Proteins for FADS3 Gene

  • Protein details for FADS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q0-FADS3_HUMAN
    Recommended name:
    Fatty acid desaturase 3
    Protein Accession:
    Q9Y5Q0
    Secondary Accessions:
    • O60426

    Protein attributes for FADS3 Gene

    Size:
    445 amino acids
    Molecular mass:
    51145 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC23396.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FADS3 Gene

Proteomics data for FADS3 Gene at MOPED

Post-translational modifications for FADS3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys225

Other Protein References for FADS3 Gene

Domains for FADS3 Gene

Gene Families for FADS3 Gene

HGNC:
  • FADS :Fatty acid desaturases

Protein Domains for FADS3 Gene

UniProtKB/Swiss-Prot:

FADS3_HUMAN
Domain:
  • The histidine box domains may contain the active site and/or be involved in metal ion binding:
    • Q9Y5Q0
  • Contains 1 cytochrome b5 heme-binding domain.:
    • Q9Y5Q0
Family:
  • Belongs to the fatty acid desaturase family.:
    • Q9Y5Q0
genes like me logo Genes that share domains with FADS3: view

Function for FADS3 Gene

Enzyme Numbers (IUBMB) for FADS3 Gene

Gene Ontology (GO) - Molecular Function for FADS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005506 iron ion binding IEA --
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with FADS3: view

Phenotypes for FADS3 Gene

GenomeRNAi human phenotypes for FADS3:
genes like me logo Genes that share phenotypes with FADS3: view

miRNA for FADS3 Gene

miRTarBase miRNAs that target FADS3

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FADS3 Gene

Localization for FADS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FADS3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FADS3 Gene COMPARTMENTS Subcellular localization image for FADS3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FADS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane NAS 10860662
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FADS3: view

Pathways for FADS3 Gene

genes like me logo Genes that share pathways with FADS3: view

Interacting Proteins for FADS3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278829%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000243997%0d%0a
Selected Interacting proteins: ENSP00000278829 for FADS3 Gene via STRING

Gene Ontology (GO) - Biological Process for FADS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0006633 fatty acid biosynthetic process --
GO:0006636 unsaturated fatty acid biosynthetic process NAS 10860662
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FADS3: view

Compounds for FADS3 Gene

(1) HMDB Compounds for FADS3 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with FADS3: view

Transcripts for FADS3 Gene

Unigene Clusters for FADS3 Gene

Fatty acid desaturase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FADS3 Gene

No ASD Table

Relevant External Links for FADS3 Gene

GeneLoc Exon Structure for
FADS3
ECgene alternative splicing isoforms for
FADS3

Expression for FADS3 Gene

mRNA expression in normal human tissues for FADS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FADS3 Gene

SOURCE GeneReport for Unigene cluster for FADS3 Gene Hs.21765

mRNA Expression by UniProt/SwissProt for FADS3 Gene

Q9Y5Q0-FADS3_HUMAN
Tissue specificity: Has been found in heart, liver, lung, uterus, and brainstem.
genes like me logo Genes that share expressions with FADS3: view

Orthologs for FADS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FADS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FADS3 36
  • 99.78 (n)
  • 100 (a)
FADS3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FADS3 36
  • 89.09 (n)
  • 88.49 (a)
FADS3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FADS3 36
  • 88.91 (n)
  • 88.46 (a)
FADS3 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fads3 36
  • 87.94 (n)
  • 90.11 (a)
Fads3 16
Fads3 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FADS3 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FADS3 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fads3 36
  • 87.79 (n)
  • 89.89 (a)
chicken
(Gallus gallus)
Aves FADS2 37
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fads2 37
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fat-3 37
  • 25 (a)
ManyToMany
fat-4 37
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for FADS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FADS3 Gene

ENSEMBL:
Gene Tree for FADS3 (if available)
TreeFam:
Gene Tree for FADS3 (if available)

Paralogs for FADS3 Gene

Paralogs for FADS3 Gene

Selected SIMAP similar genes for FADS3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FADS3: view

Variants for FADS3 Gene

Sequence variations from dbSNP and Humsavar for FADS3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs174450 -- 61,874,070(-) CGTCA(A/C)CCCGG intron-variant
rs174451 -- 61,875,291(+) acctc(C/T)gcccc intron-variant
rs174454 -- 61,883,275(+) CCTCC(A/G)GAAAC intron-variant
rs174455 -- 61,888,645(+) CATAC(A/G)CTGCA intron-variant
rs174456 -- 61,888,710(+) ACTAC(A/C)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FADS3 Gene

Variant ID Type Subtype PubMed ID
nsv528697 CNV Loss 19592680
nsv897613 CNV Loss 21882294
nsv897614 CNV Loss 21882294
nsv468585 CNV Loss 19166990
dgv217e199 CNV Deletion 23128226
nsv897615 CNV Loss 21882294
nsv897616 CNV Loss 21882294

Relevant External Links for FADS3 Gene

HapMap Linkage Disequilibrium report
FADS3

Disorders for FADS3 Gene

Relevant External Links for FADS3

Genetic Association Database (GAD)
FADS3
Human Genome Epidemiology (HuGE) Navigator
FADS3
genes like me logo Genes that share disorders with FADS3: view

No data available for UniProtKB/Swiss-Prot for FADS3 Gene

Publications for FADS3 Gene

  1. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. (PMID: 10860662) Marquardt A. … Weber B.H. (Genomics 2000) 3 4 23
  2. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. (PMID: 19148276) Tanaka T. … Ferrucci L. (PLoS Genet. 2009) 3 23 49
  3. A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. (PMID: 19750004) Plaisier C.L. … Pajukanta P. (PLoS Genet. 2009) 3 23
  4. The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues. (PMID: 19752397) PAcdrono F. … Legrand P. (J. Lipid Res. 2010) 3 23
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 49

Products for FADS3 Gene

Sources for FADS3 Gene

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