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FADS2 Gene

protein-coding GIFtS: 57

GC11P061340

fatty acid desaturase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LLCDL2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
D6D ^¹, ², ³
DES6 ^¹, ²
EC 1.14.19.- ^³
FADSD6 ^¹, ²
LLCDL2 ^²
SLL0262 ^¹, ²
TU13 ^¹, ²
delta-6-desaturase ^²

Descriptions
Delta(6) desaturase ^³
Delta(6) fatty acid desaturase ^³
delta-6 fatty acid desaturase ^²
fatty acid desaturase 2 ^²
linoleoyl-CoA desaturase (delta-6-desaturase)-like 2 ^²

External Ids
HGNC: 3575¹
Entrez Gene: 9415²
UniProtKB: O95864³
Ensembl: ENSG00000134824⁷

Search outside databases for aliases for FADS2 gene

Previous GC identifers: GC11P064097 GC11P063159 GC11P061834 GC11P061359

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FADS2:

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family.

Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds

between defined carbons of the fatty acyl chain. FADS family members are considered fusion

products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple

membrane-spanning desaturase portion, both of which are characterized by conserved histidine

motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is

thought to have arisen evolutionarily from gene duplication based on its similar exon/intron

organization. [provided by RefSeq]

UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864

Function: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated

fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA)

(18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in

this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid

(GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly

unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as

well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid

sapienate, the most abundant fatty acid in sebum

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FADS2 gene

Entrez Gene cytogenetic band: 11q12-q13.1 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2

FADS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P061340: (about GC identifiers)

Start:	61,340,325 bp from pter
End:	61,391,401 bp from pter
Size:	51,077 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864 (See protein sequence)

Recommended Name: Fatty acid desaturase 2

Size: 444 amino acids; 52259 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)

Developmental stage: Found in fetal heart

Secondary accessions: Q6MZQ7 Q96H07 Q96SV8 Q9H3G3 Q9Y3X4

Alternative splicing: 3 isoforms: O95864-1 O95864-2 O95864-3

REFSEQ proteins: NP_004256.1

ENSEMBL proteins:

ENSP00000257261 ENSP00000278840

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FADS2)
	Human Recombinant Proteins from Abnova (FADS2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	9867867
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9867867
GO:0016020	membrane	IEA	--

About this table

Antibodies for FADS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FADS2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FADS2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for FADS2

Assays for FADS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95864

ProtoNet protein and cluster: O95864

1 Blocks protein family: IPB001199 Cytochrome b5

UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864

Domain: The histidine box domains may contain the active site and/or be involved in metal ion

binding

Similarity: Belongs to the fatty acid desaturase family

Similarity: Contains 1 cytochrome b5 heme-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADS2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004265

Applied Biosystems Silencer® siRNAs for FADS2

Sigma-Aldrich siRNA and siRNA Panels for FADS2

Sigma-Aldrich shRNA for FADS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FADS2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004265
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004265
untagged cDNA clone in CMV expression vector: NM_004265

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004265

UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864

Function: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated

fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA)

(18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in

this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid

(GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly

unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as

well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid

sapienate, the most abundant fatty acid in sebum

Induction: Repressed by dietary highly unsaturated fatty acids

Enzyme Number (IUBMB): EC 1.14.19.-

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fads2):

	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004768	stearoyl-CoA 9-desaturase activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0020037	heme binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for FADS2 (Your Favorite Gene powered by Ingenuity)

Linoleic Acid Metabolism

GeneDecks FADS2 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864

Pathway: Lipid metabolism; polyunsaturated fatty acid biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for FADS2

5/19 Interacting proteins for FADS2 (O95864² ENSP00000278840³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SCD	ENSP00000359380³	STRING (score=.957)
CYB5A	ENSP00000341625³	STRING (score=.91)
ACSL1	ENSP00000281455³	STRING (score=.899)
PLA2G10	ENSP00000261659³	STRING (score=.899)
PLA2G12A	ENSP00000243501³	STRING (score=.899)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006636	unsaturated fatty acid biosynthetic process	TAS	9867867
GO:0006810	transport	IEA	--
GO:0022900	electron transport chain	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FADS2
4 Novoseek chemical compound relationships for FADS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parinaric acid	83.86	3	15481543 (1), 15966318 (1)
alpha-linolenic acid	75.31	10	15971598 (1), 12713571 (1), 15481543 (1), 18842780 (1) (see all 5)
linoleic acid	73.18	12	18842780 (2), 15971598 (1), 12713571 (1), 18936223 (1) (see all 6)
fatty acid	69.70	15	12951357 (3), 19195843 (2), 11290821 (1), 19148276 (1) (see all 8)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADS2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004265

Sigma-Aldrich siRNA and siRNA Panels for FADS2

Sigma-Aldrich shRNA for FADS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004265

REFSEQ mRNAs for FADS2 gene:

NM_004265.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004265

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004265
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004265
                                 untagged cDNA clone in CMV expression vector: NM_004265

Additional cDNA sequence:

AF084559.1 AF108658.1 AF126799.1 AK027459.1 AK027513.1 AK027577.1 AK074925.1 AK074939.1

AK074991.1 AK123240.1 AK290291.1 AK299762.1 AL050118.1 BC009011.1 CR593148.1 CR599697.1

CR610979.1 CR617384.1

24/31 DOTS entries (see all 31 ):

DT.100821496 DT.455705 DT.95113197 DT.100821494 DT.100836017 DT.120740171 DT.95094120 DT.120740049

DT.100821504 DT.120740019 DT.120739988 DT.95094121 DT.92456403 DT.120740037 DT.100821499 DT.100830160

DT.120740027 DT.92456410 DT.101968013 DT.101978227 DT.120739976 DT.120740069 DT.120740087 DT.87016735

24/474 AceView cDNA sequences (see all 474 ):

BP381955 BQ880510 BM682605 AW059622 CF541153 CA489400 AU100330 BG390559

AL530346 AW296357 AL559447 BU174067 AA775443 CR593148 T30521 BG742318

BG696607 Z40715 BM802824 AW191853 BG740405 BU626230 BQ883702 AA662525

highest scoring ESTs for FADS2:

AL050118 AA337430 AA339338 AA450134 AA564889 AA593565 AA642634 AA662525 AA665550 AA677778

Unigene Cluster for FADS2:

Fatty acid desaturase 2

Hs.502745 [show with all ESTs]

Unigene Representative Sequence: NM_004265

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FADS2

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8
SP1:													-		-
SP2:

About this scheme

ECgene alternative splicing isoforms for FADS2

2 Ensembl transcripts including schematic representations:

ENST00000257261 ENST00000278840

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FADS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FADS2

¹ / ² / ³

9 probe-sets matching FADS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64953_i_at²^{, 3}	U95-C	1	1.00	1.00	0.56	0.42	AI937897	0.60	1.00	0.82	1
32190_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.95	AL050118	1.00	1.00	1.00	1
64954_r_at²^{, 3}	U95-C	1	1.00	1.00	0.37	1.36	AI937897	0.60	1.00	0.82	1
72859_at²^{, 3}	U95-D	1	0.31	1.00	0.70	1.34	AI871036	0.20	0.50	0.38	1
87879_r_at*²^{, 3}	U95-D	1	1.00	1.00	0.40	0.98	T78856	0.40	1.00	0.76	1
243953_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R40016	0.60	1.00	0.82	1
202218_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004265	0.60	1.00	0.82	1
243953_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202218_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FADS2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTACTTCCCC

SOURCE GeneReport for Unigene cluster: Hs.502745
Expression variation in blood from EXPOLDB for FADS2
UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864
Tissue specificity: Expressed in a wide array of tissues, highest expression is found in liver
followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared
with normal tissues; lowest levels were found in patients with poor prognostic index

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FADS2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FADS2¹	--	fatty acid desaturase 2	90.67(n) 89.84(a)	483792 XM_540913.2 XP_540913.2
chimpanzee (Pan troglodytes)	FADS2¹	--	fatty acid desaturase 2	99.77(n) 99.77(a)	451244 XM_508482.2 XP_508482.2
cow (Bos taurus)	FADS2¹	--	fatty acid desaturase 2	89.41(n) 89.19(a)	521822 XM_600092.3 XP_600092.3
rat (Rattus norvegicus)	Fads2¹	--	fatty acid desaturase 2	87.31(n) 88.29(a)	83512 NM_031344.2 NP_112634.1
mouse (Mus musculus)	Fads2^{1, 5}	19⁵	fatty acid desaturase 2^{1, 5}	87.24(n)¹ 87.61(a)¹	56473¹ NM_019699.1¹ NP_062673.1¹ AF126798⁵ AK013642⁵ (see all 15)

About this table Species with no ortholog for FADS2

ENSEMBL Gene Tree for FADS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FADS2 gene

LOC643181² FADS1² FADS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/268 NCBI SNPs in FADS2 are shown (see all 268 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 114)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs968567^1,2	C,F,H	61352140(-)	`CCCGGG/AAGCTC`	1	--	ng5¹		5		MN EU EA WA	604
	rs482548^1,2	C,F,H	61389758(+)	`GACACC/TGTGGG`	1	--	ut3¹ ese³		12		EA NA EU WA	996
	rs17831757^1,2	F,H	61391776(+)	`CAATCT/CGCCCT`	1	--	ng3¹		7		NA EU EA WA	560
	rs7119667^1,2	F,H	61391128(+)	`TAACCC/GACTAA`	1	--	ut3¹ ese³		4		EU EA WA	420
--	rs3834458^1,2	C,F	61351497(+)	`TTTTCT/-AAGAT`	1	--	ng5¹		2		MN EA	376
	rs17764324^1,2	F,H	61391664(+)	`ACAGGG/TCTGAG`	1	--	ng3¹		7		NA EU EA WA	562
	rs17156516^1,2	F,H	61390280(+)	`AGCTCG/AGGTCT`	1	--	ut3¹		7		NA EU EA WA	560
	rs11602202^1,2	H	61352296(+)	`GGGGCG/CCGGTG`	1	--	ut5¹		3		EA WA	298
--	rs174623^1,2	C	61391870(-)	`gccacC/Tgctcc`	1	--	ng3¹		0	--	--	--	--
	rs2526677^1,2	H	61381569(-)	`CAGTTC/TTTATG`	1	K/K	syn¹ ese³		4		EU EA WA	404

About this table

HapMap Linkage Disequilibrium images for FADS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606149

UniProtKB/Swiss-Prot: FADS2_HUMAN, O95864

Defects in FADS2 are the cause of fatty acid delta-6-desaturase deficiency. This

deficiency is associated with corneal ulceration, feeding intolerance, growth failure, marked

photophobia and skin abnormalities. All of this symptoms significantly improved with a diet

supplemented with a mixture of archidonic acid, 20:4(n-6), and docosahexaenoic acid (DHA),

22:6(n-3). The deficiency is caused by mutations in the promoter region of FADS2

Human Gene Mutation Database: FADS2
Human Genome Epidemiology Navigator: FADS2 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/41 PubMed articles for FADS2 gene (see all 41 ):

A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. (PubMed id 12951357)^{1, 3, 4} Nwankwo J.O.... Domann F.E. (2003)
cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. (PubMed id 10860662)^{1, 3, 4} Marquardt A.... Weber B.H. (2000)
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity. (PubMed id 12713571)^{1, 3, 4} Ge L.... Prouty S.M. (2003)
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)^{3, 4} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. (PubMed id 12562861)^{3, 4} Tang C.... Clarke S.D. (2003)
Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. (PubMed id 12851727)^{3, 4} Lane J.... Jiang W.G. (2003)
The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids. (PubMed id 12147235)^{3, 4} Nara T.Y.... Nakamura M.T. (2002)
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. (PubMed id 9867867)^{3, 4} Cho H.P.... Clarke S.D. (1999)
Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. (PubMed id 18936223)^{1, 3} Xie L. and Innis S.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9415	HGNC: 3575	AceView: FADS2	Ensembl:ENSG00000134824	euGenes: HUgn9415
ECgene: FADS2	H-InvDB: FADS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FADS2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FADS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FADS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FADS2		Antibodies for FADS2
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FADS2 Gene at Home site.
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FADS2 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for FADS2

Summaries
for FADS2

Genomic Location
for FADS2

Proteins
for FADS2

Protein Domains/
Families
for FADS2

Gene Function
for FADS2

Pathways & Interactions
for FADS2

Drugs & Compounds
for FADS2

Transcripts
for FADS2

Expression
for FADS2

Orthologs
for FADS2

Paralogs
for FADS2

SNPs/Variants
for FADS2

Disorders & Mutations
for FADS2

Medical News
for FADS2

Publications
for FADS2

Search for FADS2

Genome Databases showing FADS2

Other Databases showing FADS2

Specialized Databases showing FADS2

Licensable Technologies
for FADS2

Services
for FADS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FADS2 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor FADS2

Summariesfor FADS2

Genomic Locationfor FADS2

Proteinsfor FADS2

Protein Domains/Familiesfor FADS2

Gene Functionfor FADS2

Pathways & Interactionsfor FADS2

Drugs & Compoundsfor FADS2

Transcriptsfor FADS2

Expression for FADS2

Orthologsfor FADS2

Paralogsfor FADS2

SNPs/Variantsfor FADS2

Disorders & Mutationsfor FADS2

Medical Newsfor FADS2

Publicationsfor FADS2

Search for FADS2

Genome Databases showing FADS2

Other Databases showing FADS2

Specialized Databases showing FADS2

Licensable Technologiesfor FADS2

Servicesfor FADS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FADS2

Summaries
for FADS2

Genomic Location
for FADS2

Proteins
for FADS2

Protein Domains/
Families
for FADS2

Gene Function
for FADS2

Pathways & Interactions
for FADS2

Drugs & Compounds
for FADS2

Transcripts
for FADS2

Expression
for FADS2

Orthologs
for FADS2

Paralogs
for FADS2

SNPs/Variants
for FADS2

Disorders & Mutations
for FADS2

Medical News
for FADS2

Publications
for FADS2

Licensable Technologies
for FADS2

Services
for FADS2