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FADS1 Gene

protein-coding GIFtS: 57

GC11M061323

fatty acid desaturase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LLCDL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
D5D ^¹, ², ³
EC 1.14.19.- ^³
FADS6 ^¹, ²
FADSD5 ^¹, ², ³
FLJ38956 ^²
FLJ90273 ^²
LLCDL1 ^²
TU12 ^¹, ²

Descriptions
Delta(5) desaturase ^², ³
Delta(5) fatty acid desaturase ^³
delta-5 desaturase ^²
delta-5 fatty acid desaturase ^²
fatty acid desaturase 1 ^²
linoleoyl-CoA desaturase (delta-6-desaturase)-like 1 ^²

External Ids
HGNC: 3574¹
Entrez Gene: 3992²
UniProtKB: O60427³
Ensembl: ENSG00000149485⁷

Search outside databases for aliases for FADS1 gene

Previous GC identifers: GC11M064080 GC11M063143 GC11M061817 GC11M061342

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FADS1:

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family.

Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds

between defined carbons of the fatty acyl chain. FADS family members are considered fusion

products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple

membrane-spanning desaturase portion, both of which are characterized by conserved histidine

motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is

thought to have arisen evolutionarily from gene duplication based on its similar exon/intron

organization. [provided by RefSeq]

UniProtKB/Swiss-Prot: FADS1_HUMAN, O60427

Function: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated

fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA)

(18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of

dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate

arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively

Gene Wiki entry for FADS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FADS1 gene

Entrez Gene cytogenetic band: 11q12.2-q13.1 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12-q13.1

FADS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M061323: (about GC identifiers)

Start:	61,323,679 bp from pter
End:	61,340,886 bp from pter
Size:	17,208 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FADS1_HUMAN, O60427 (See protein sequence)

Recommended Name: Fatty acid desaturase 1

Size: 444 amino acids; 51964 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)

Developmental stage: Highly expressed in fetal liver and fetal brain

Secondary accessions: B2RAI0 Q53GM5 Q8N3A6 Q8NCC7 Q8NCG0 Q96I39 Q96SV3 Q96T10 Q9NRP8 Q9NYX1

REFSEQ proteins: NP_037534.3

ENSEMBL proteins:

ENSP00000322229

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FADS1)
	Human Recombinant Proteins from Abnova (FADS1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	NAS	10601301
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	NAS	10601301
GO:0016020	membrane	IEA	--

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Antibodies for FADS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FADS1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FADS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FADS1)
	Novus Biologicals Antibodies for FADS1

Assays for FADS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O60427

ProtoNet protein and cluster: O60427

1 Blocks protein family: IPB001199 Cytochrome b5

UniProtKB/Swiss-Prot: FADS1_HUMAN, O60427

Domain: The histidine box domains may contain the active site and/or be involved in metal ion

binding

Similarity: Belongs to the fatty acid desaturase family

Similarity: Contains 1 cytochrome b5 heme-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FADS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013402

Applied Biosystems Silencer® siRNAs for FADS1

Sigma-Aldrich siRNA and siRNA Panels for FADS1

Sigma-Aldrich shRNA for FADS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FADS1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_013402
Myc/DDK tagged cDNA clone in CMV expression vector: NM_013402
untagged cDNA clones in CMV expression vector (see all 3): BD127299

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013402

UniProtKB/Swiss-Prot: FADS1_HUMAN, O60427

Function: Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated

fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA)

(18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of

dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate

arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively

Enzyme Number (IUBMB): EC 1.14.19.-

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000248	C-5 sterol desaturase activity	TAS	10601301
GO:0005515	protein binding	IPI	17353931
GO:0016491	oxidoreductase activity	IDA	10601301
GO:0020037	heme binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for FADS1 (Your Favorite Gene powered by Ingenuity)

Linoleic Acid Metabolism
Inositol Metabolism

GeneDecks FADS1 for the pathways selected above

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UniProtKB/Swiss-Prot: FADS1_HUMAN, O60427

Pathway: Lipid metabolism; polyunsaturated fatty acid biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for FADS1

5/13 Interacting proteins for FADS1 (ENSP00000322229³ O60427¹) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DHCR7	Q9UBM7¹	EBI-1055473, EBI-1054468
PAAF1	Q9BRP4¹	EBI-1055473, EBI-1056358
-	Q65ZQ1¹	EBI-1055473, EBI-1054063
SCD	ENSP00000359380³	STRING (score=.957)
CLDN10	ENSP00000299339³	STRING (score=.899)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006636	unsaturated fatty acid biosynthetic process	IDA	10601301
GO:0006810	transport	IEA	--
GO:0007267	cell-cell signaling	NAS	10601301
GO:0008654	phospholipid biosynthetic process	TAS	10601301
GO:0009267	cellular response to starvation	IDA	10601301

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FADS1
9 Novoseek chemical compound relationships for FADS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dihomo-gamma-linolenic acid	85.98	5	9192987 (1), 11742889 (1), 17466497 (1), 16201244 (1)
fatty acid	79.10	19	10727010 (1), 15748617 (1), 16846730 (1), 19195843 (1) (see all 14)
linoleic acid	77.94	14	17655842 (2), 18842780 (2), 17551762 (1), 10991775 (1) (see all 9)
arachidonic acid	73.03	20	9566835 (2), 18842780 (2), 12538079 (1), 15015135 (1) (see all 13)
docosahexaenoic acid	69.25	4	10991775 (1), 14988642 (1), 17466497 (1)
eicosapentaenoic acid	61.94	5	14988642 (1), 17466497 (1), 18842780 (1)
lipid	46.69	4	16846730 (1), 17136489 (1), 15189125 (1), 18936223 (1)
cholesterol	45.28	2	12030318 (1), 12706457 (1)
phospholipid	35.43	2	18626191 (1), 18936223 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FADS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013402

Sigma-Aldrich siRNA and siRNA Panels for FADS1

Sigma-Aldrich shRNA for FADS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_013402

REFSEQ mRNAs for FADS1 gene:

NM_013402.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_013402

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_013402
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_013402
                                 untagged cDNA clones in CMV expression vector (see all 3): BD127299

Additional cDNA sequence:

AF035284.1 AF084558.1 AF199596.1 AF226273.1 AF271778.1 AK027427.1 AK027522.1 AK074754.1

AK074819.1 AK096275.1 AK222906.1 AK289552.1 AK298871.1 AK314199.1 AL512760.1 AL834479.1

BC007846.2 CR591980.1 CR597486.1 CR602403.1 CR611884.1

24/34 DOTS entries (see all 34 ):

DT.91817665 DT.449027 DT.92012441 DT.100832147 DT.100030170 DT.99934273 DT.100663661 DT.100663654

DT.100030171 DT.95265965 DT.212451 DT.91809922 DT.95265967 DT.70104817 DT.91976567 DT.100016911

DT.100863409 DT.120740062 DT.120740158 DT.75154374 DT.95227593 DT.95285623 DT.100860557 DT.120739920

24/25 AceView cDNA sequences (see all 25 ):

AK096275 CR597486 AL512760 AL834479 CR602403 NM_013402 BC007846 CR591980

AK074819 CR611884 AK027522 AF199596 AF084558 AF226273 AU132018 AK027427

AK074754 AF009756 BX388117 BF838230 AF271778 BF835985 BF742188 BF083018

highest scoring ESTs for FADS1:

AK027427 AK027522 AK074754 AK074819 BC007846 AF084558 AL512760 AA613790 AF009756 AF009757

Unigene Cluster for FADS1:

Fatty acid desaturase 1

Hs.503546 [show with all ESTs]

Unigene Representative Sequence: NM_013402

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for FADS1 (see all 18 )

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	·	19c	^
SP1:					-		-		-		-		-		-										-
SP2:
SP3:																									-
SP4:																									-
SP5:																																															-		-		-

ExUns:	20a	·	20b	·	20c	·	20d	^	21	^	22a	·	22b	^	23	^	24	^	25a	·	25b	·	25c	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33
SP1:
SP2:
SP3:
SP4:
SP5:	-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for FADS1

1 Ensembl transcript including schematic representation:

ENST00000350997

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FADS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FADS1

¹ / ² / ³

12 probe-sets matching FADS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39372_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.41	W26480	0.60	1.00	0.82	1
41720_r_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.82	AF009767	0.40	1.00	0.76	1
41717_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.83	AC004770	0.20	0.33	0.27	1
39373_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.80	AF035284	0.60	0.75	0.68	1
41718_g_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.15	AC004770	0.20	0.33	0.27	1
41719_i_at²^{, 3}	U95-A	1	1.00	1.00	0.66	0.36	AF009767	0.40	1.00	0.76	1
208962_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE540552	0.40	1.00	0.76	1
208963_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BG165833	0.40	0.67	0.55	1
208964_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AL512760	0.80	0.88	0.84	1
208962_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208963_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
208964_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks FADS1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCGGGCGTGG

SOURCE GeneReport for Unigene cluster: Hs.503546
Expression variation in blood from EXPOLDB for FADS1
UniProtKB/Swiss-Prot: FADS1_HUMAN, O60427
Tissue specificity: Expressed in many tissues, it is most abundant in the liver, brain, adrenal
gland and heart. Found as well in skeletal muscle, lung, placenta, kidney, pancreas and retina

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for FADS1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FADS1¹	--	fatty acid desaturase 1	91.46(n) 90.85(a)	483793 XM_540914.2 XP_540914.2
chimpanzee (Pan troglodytes)	FADS1¹	--	fatty acid desaturase 1	100(n) 100(a)	451243 XM_001150290.1 XP_001150290.1
cow (Bos taurus)	FADS1¹	--	fatty acid desaturase 1	91.33(n) 93.67(a)	533107 XM_612398.3 XP_612398.3
rat (Rattus norvegicus)	Fads1¹	--	fatty acid desaturase 1	85.96(n) 88.51(a)	84575 NM_053445.1 NP_445897.1
mouse (Mus musculus)	Fads1^{1, 5}	19⁵	fatty acid desaturase 1^{1, 5}	85.89(n)¹ 88.96(a)¹	76267¹ NM_146094.1¹ NP_666206.1¹ AB072976⁵ AF061504⁵ (see all 42)

About this table Species with no ortholog for FADS1

ENSEMBL Gene Tree for FADS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for FADS1 gene

FADS2² LOC643181² FADS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/75 NCBI SNPs in FADS1 are shown (see all 75 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs174545^1,2	A,C,F,H,O	61325882(+)	`AGAAGC/GCACTG`	1	--	ut3¹		5		MN EU EA WA	590
	rs174546^1,2	A,C,F,H	61326406(+)	`TCTGCC/TTTGGC`	1	--	ut3¹		8		EU EA WA NA	2046
	rs145902^1,2	C,H	61325345(+)	`GTTGGG/AAAGCA`	1	--	ut3¹		4		EU EA WA	414
--	rs174544^1,2	C,F	61324329(+)	`CTTGAC/ACTCCT`	1	--	ut3¹		1		MN	184
--	rs17156381^1,2	F,H	61325036(+)	`TTTCCA/CGAAGA`	1	--	ut3¹		6		NA EU EA	442
	rs174542^1,2	H	61323529(+)	`GGGTCC/GTGATG`	1	--	ng5¹		4		EU EA WA	400
	rs11601366^1,2	C	61325871(+)	`AATGAG/TGATGG`	1	--	ut3¹		0	--	--	--	--
	rs145903^1,2	H	61325446(+)	`CAGTCC/TTAGAA`	1	--	ut3¹		4		EU EA WA	420
--	rs17856235^1,2	H	61328801(+)	`GGCTGG/AGGGCC`	1	S/P	mis¹ ese³		4		EU EA WA	420
	rs174555^1,2	A,C,F,H,O	61336336(+)	`AGATGT/CCCATG`	1	--	int¹		9		MN NA EU EA WA	807

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HapMap Linkage Disequilibrium images for FADS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 606148

2 Novoseek disease relationships for FADS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin resistance	44.13	6	15850715 (3), 16896932 (1), 9833942 (1), 8675650 (1)
obesity	20.04	2	8675650 (1), 15850715 (1)

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Human Genome Epidemiology Navigator: FADS1 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/83 PubMed articles for FADS1 gene (see all 83 ):

cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. (PubMed id 10860662)^{1, 3, 4} Marquardt A.... Weber B.H. (2000)
cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid. (PubMed id 10769175)^{1, 3, 4} Leonard A.E.... Mukerji P. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Cloning, expression, and fatty acid regulation of the human Delta-5 desaturase. (PubMed id 10601301)^{3, 4} Cho H.P.... Clarke S.D. (1999)
A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase. (PubMed id 16846730)^{1, 3} Dreesen T.D....Gettys T.W. (2006)
Genetically determined variation in polyunsaturated Fatty Acid metabolism may result in different dietary requirements. (PubMed id 18626191)^{1, 3} Koletzko B....Heinrich J. (2008)
Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. (PubMed id 17655842)^{1, 3} Rise P....Galli C. (2007)
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. (PubMed id 19148276)^{1, 3} Tanaka T....Ferrucci L. (2009)
Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. (PubMed id 18936223)^{1, 3} Xie L. and Innis S.M. (2008)
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. (PubMed id 18842780)^{1, 3} Martinelli N....Olivieri O. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3992	HGNC: 3574	AceView: FADS1	Ensembl:ENSG00000149485	euGenes: HUgn3992
ECgene: FADS1	H-InvDB: FADS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for FADS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FADS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FADS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FADS1		Antibodies for FADS1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FADS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FADS1)
	Antibodies (FADS1)
	Chimera RNAi (FADS1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FADS1)
	Antibodies (FADS1)

Search OriGene for FADS1

Search Tocris compounds for FADS1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FADS1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FADS1 Gene at Home site.
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FADS1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for FADS1

Summaries
for FADS1

Genomic Location
for FADS1

Proteins
for FADS1

Protein Domains/
Families
for FADS1

Gene Function
for FADS1

Pathways & Interactions
for FADS1

Drugs & Compounds
for FADS1

Transcripts
for FADS1

Expression
for FADS1

Orthologs
for FADS1

Paralogs
for FADS1

SNPs/Variants
for FADS1

Disorders & Mutations
for FADS1

Medical News
for FADS1

Publications
for FADS1

Search for FADS1

Genome Databases showing FADS1

Other Databases showing FADS1

Specialized Databases showing FADS1

Licensable Technologies
for FADS1

Services
for FADS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FADS1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor FADS1

Summariesfor FADS1

Genomic Locationfor FADS1

Proteinsfor FADS1

Protein Domains/Familiesfor FADS1

Gene Functionfor FADS1

Pathways & Interactionsfor FADS1

Drugs & Compoundsfor FADS1

Transcriptsfor FADS1

Expression for FADS1

Orthologsfor FADS1

Paralogsfor FADS1

SNPs/Variantsfor FADS1

Disorders & Mutationsfor FADS1

Medical Newsfor FADS1

Publicationsfor FADS1

Search for FADS1

Genome Databases showing FADS1

Other Databases showing FADS1

Specialized Databases showing FADS1

Licensable Technologiesfor FADS1

Servicesfor FADS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FADS1

Summaries
for FADS1

Genomic Location
for FADS1

Proteins
for FADS1

Protein Domains/
Families
for FADS1

Gene Function
for FADS1

Pathways & Interactions
for FADS1

Drugs & Compounds
for FADS1

Transcripts
for FADS1

Expression
for FADS1

Orthologs
for FADS1

Paralogs
for FADS1

SNPs/Variants
for FADS1

Disorders & Mutations
for FADS1

Medical News
for FADS1

Publications
for FADS1

Licensable Technologies
for FADS1

Services
for FADS1