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FADD Gene

protein-coding GIFtS: 66

GC11P069726

Fas (TNFRSF6)-associated via death domain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GIG3 ^¹, ²
MGC8528 ^²
MORT1 ^¹, ², ³

Descriptions
FAS-associated death domain protein ^³
FAS-associating death domain-containing protein ^², ³
Fas (TNFRSF6)-associated via death domain ^²
Fas-associated via death domain ^²
Fas-associating protein with death domain ^²
Growth-inhibiting gene 3 protein ^², ³
Mediator of receptor induced toxicity ^³
mediator of receptor-induced toxicity ^²

External Ids
HGNC: 3573¹
Entrez Gene: 8772²
UniProtKB: Q13158³
Ensembl: ENSG00000168040⁷

Search outside databases for aliases for FADD gene

Previous GC identifers: GC11P072381 GC11P071572 GC11P070271 GC11P069775

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FADD:

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface

receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein

can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and

TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these

receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain

of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease

cascade. Knockout studies in mice also suggest the importance of this protein in early T cell

development. [provided by RefSeq]

UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158

Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas

(CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex

(DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent

cascade of caspases mediating apoptosis

Gene Wiki entry for FADD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FADD gene

Entrez Gene cytogenetic band: 11q13.3 Ensembl cytogenetic band: 11q13.3 HGNC cytogenetic band: 11q13.3

FADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P069726: (about GC identifiers)

Start:	69,726,917 bp from pter
End:	69,731,144 bp from pter
Size:	4,228 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158 (See protein sequence)

Recommended Name: Protein FADD

Size: 208 amino acids; 23279 Da

Subunit: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing

HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD

PDB structures from and Proteopedia :

1A1W (3D)

1A1Z (3D)

1E3Y (3D)

1E41 (3D)

2GF5 (3D)

3EZQ (3D)

Secondary accessions: Q14866 Q6IBR4

Post-translational modifications:

Phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003815.1

ENSEMBL proteins:

ENSP00000301838

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for FADD
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FADD)
	Human Recombinant Proteins from Abnova (FADD)

OriGene Purified Recombinant Human Protein: FADD

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005829	cytosol	EXP	7536190 8681376 9721089 10894160 12887920

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Antibodies for FADD:

	Invitrogen Antibodies for FADD
	Millipore Mono- and Polyclonal Antibodies for the study of FADD
	Sigma-Aldrich Antibody Arrays and Antibodies for FADD
	R&D Systems Antibodies for FADD
	Cell Signaling Technology (CST) Antibodies for FADD
	Antibodies from Abcam (FADD), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FADD)
	Novus Biologicals Antibodies for FADD

Assays for FADD:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13158

ProtoNet protein and cluster: Q13158

2 Blocks protein families:

IPB000488 Death domain

IPB001875 Death effector protein

UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158

Domain: Contains a death domain involved in the binding of the corresponding domain within Fas

receptor

Similarity: Contains 1 death domain

Similarity: Contains 1 DED (death effector) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FADD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003824

Applied Biosystems Silencer® siRNAs for FADD

Sigma-Aldrich siRNA for FADD

Sigma-Aldrich shRNA Panels and shRNA for FADD

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FADD
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003824
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003824
untagged cDNA clone in CMV expression vector: NM_003824

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003824

UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158

Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas

(CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex

(DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent

cascade of caspases mediating apoptosis

Genatlas biochemistry entry for FADD:

Fas-associated DEATH domain protein (FADD/MORT1),23kDa,intracellular mediator of lymphocyte

apoptosis,associating with the DEATH domain of TNFRSF6 and CASP8

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fadd):

	cellular	embryogenesis	growth/size	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	liver/biliary system	muscle

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005123	death receptor binding	TAS	7538907
GO:0042802	identical protein binding	IPI	7536190

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for FADD (Your Favorite Gene powered by Ingenuity) (see all 10 )

Activation of IRF by Cytosolic Pattern Recognition Receptors
SAPK/JNK Signaling
Type I Diabetes Mellitus Signaling
Molecular Mechanisms of Cancer
p38 MAPK Signaling

GeneDecks FADD for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FADD

5/117 Interacting proteins for FADD (Q13158^{1, 2} ENSP00000301838³) via UniProtKB, MINT, and/or STRING (see all 117 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FASLG	P48023², ENSP00000356694³	MINT-1956230 STRING (score=.999)
CASP8AP2	Q9UKL3², ENSP00000237177³	MINT-19104 STRING (score=.825)
EDA2R	Q9HAV5¹, ENSP00000253392³	EBI-494804, EBI-526033 STRING (score=.802)
XPO5	Q9HAV4¹, ENSP00000265351³	EBI-494804, EBI-517949 STRING (score=.746)
FAS	P25445¹^,², ENSP00000360942³	EBI-494804, EBI-494743 MINT-1956556 MINT-18737 MINT-1787390 MINT-4055373 MINT-4055358 EBI-494804, EBI-494743 MINT-1956556 MINT-18737 MINT-1787390 MINT-4055373 MINT-4055358 STRING (score=.999)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0008625	induction of apoptosis via death domain receptors	TAS	7538907
GO:0008633	activation of pro-apoptotic gene products	EXP	14644197
GO:0042981	regulation of apoptosis	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP	12761501

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FADD
9 Novoseek chemical compound relationships for FADD gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ceramide	51.80	6	10722705 (2), 10616904 (1), 16397504 (1), 16357153 (1) (see all 5)
sp 600125	19.10	1	15001534 (1)
oxygen	0.00	2	15452117 (1), 11709711 (1)
oligonucleotide	0.00	1	12740905 (1)
cholesterol	0.00	1	12902349 (1)
lipid	0.00	7	16438619 (2), 19352436 (2), 19242990 (1), 18564399 (1)
ethanol	0.00	1	17088943 (1)
tyrosine	0.00	1	9174612 (1)
phosphatidylinositol	0.00	1	17785432 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FADD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FADD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003824

Sigma-Aldrich siRNA for FADD

Sigma-Aldrich shRNA Panels and shRNA for FADD

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003824

REFSEQ mRNAs for FADD gene:

NM_003824.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003824

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003824
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003824
                                 untagged cDNA clone in CMV expression vector: NM_003824

Additional cDNA sequence:

AK291005.1 AK293320.1 AY423721.1 BC000334.2 BC025733.1 BT006927.1 CR456738.1 CR591208.1

CR593101.1 CR593331.1 CR595812.1 CR596013.1 CR599691.1 CR600474.1 CR605817.1 CR607000.1

CR608391.1 CR610334.1 CR615437.1 CR616686.1 CR621957.1 U24231.1 X84709.1

5 DOTS entries:

DT.453779 DT.101975002 DT.100799955 DT.100799957 DT.120721306

24/318 AceView cDNA sequences (see all 318 ):

CR607000 BQ690011 BM713213 BU168801 BQ441706 BU684356 CR599691 BU957269

BM797371 CR591208 BQ688047 CF529895 BG821754 BQ686680 CR615437 CR616686

BQ016423 CR610334 CR608391 BU145379 CK904421 CR605817 BG260182 BQ672502

highest scoring ESTs for FADD:

X84709 AA161297 AA199646 AA199680 AA203489 AA233608 AA233614 AA233669 AA353313 AA501671

Unigene Cluster for FADD:

Fas (TNFRSF6)-associated via death domain

Hs.86131 [show with all ESTs]

Unigene Representative Sequence: NM_003824

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000301838

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FADD expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FADD

¹ / ² / ³

3 probe-sets matching FADD gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38755_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X84709	1.00	1.00	1.00	1
202535_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003824	0.60	1.00	0.82	1
202535_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FADD for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGGGGTGG

SOURCE GeneReport for Unigene cluster: Hs.86131
Expression variation in blood from EXPOLDB for FADD
UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158
Tissue specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear
leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FADD gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	FADD¹	--	Fas (TNFRSF6)-associated via death domain	98.88(n) 98.08(a)	451389 XM_508611.2 XP_508611.2
cow (Bos taurus)	FADD¹	--	Fas (TNFRSF6)-associated via death domain	76.86(n) 66.99(a)	493720 NM_001007816.1 NP_001007817.1
rat (Rattus norvegicus)	Fadd¹	--	Fas (TNFRSF6)-associated via death domain	75.24(n) 68.93(a)	266610 NM_152937.1 NP_690920.1
mouse (Mus musculus)	Fadd^{1, 5}	7 (70.00 cM)⁵	Fas (TNFRSF6)-associated via death domain^{1, 5}	76.19(n)¹ 69.46(a)¹	14082¹ NM_010175.3¹ NP_034305.1¹ AK007648⁵ AK031396⁵ (see all 14)
chicken (Gallus gallus)	FADD¹	--	Fas (TNFRSF6)-associated via death domain	56.28(n) 46.75(a)	776859 XM_001236355.1 XP_001236356.1

About this table Species with no ortholog for FADD

ENSEMBL Gene Tree for FADD

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/62 NCBI SNPs in FADD are shown (see all 62 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3740720^1,2	A,C,F,H	69731195(-)	`GTACTA/GGGAAT`	1	--	ng3¹		19	EA EU WA NA NS	3050
	rs1131715^1,2	A,C,F,H	69731135(+)	`CCATAT/CTACAA`	1	--	ut3¹		9	EU EA WA NS	596
	rs1131677^1,2	A,C,F	69727171(+)	`GGCGCG/ACGGAG`	1	--	ut5¹ ese³		7	MN EA NS	1442
--	rs7113721^1,2	A,C,F	69725660(+)	`aaaggT/Ctgcag`	1	--	ng5¹		5	NS	182
--	rs7109831^1,2	A,C,F	69724983(+)	`atgcaG/Tccata`	1	--	ng5¹		5	NS	180
--	rs10898853^1,2	A,C,F	69726901(+)	`CCACCC/TCCCAC`	1	--	ng5¹		7	MN EA NS	1430
--	rs7106327^1,2	A,C,F	69725266(+)	`cctggG/Acaaaa`	1	--	ng5¹		5	NS	180
--	rs7126976^1,2	C,F	69726944(+)	`CAGAAG/ACCGCG`	1	--	ut5¹		5	NS	178
--	rs11235536^1,2	C,F	69726329(+)	`ctcacT/Gatgtt`	1	--	ng5¹		5	NS	170
--	rs34882300^1,2	C,F	69724997(+)	`AGGAAG/AGAGGC`	1	--	ng5¹		5	NS	180

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HapMap Linkage Disequilibrium images for FADD (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602457

10/29 Novoseek disease relationships for FADD gene (see all 29 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune lymphoproliferative syndrome	66.62	1	8955195 (1)
necrosis	66.55	27	16289096 (2), 18946037 (2), 10952991 (2), 16424911 (1) (see all 22)
tumors	55.40	31	10952991 (2), 8955195 (1), 15991280 (1), 18269865 (1) (see all 24)
leukemia	34.09	1	12506034 (1)
cancer	27.58	14	15906275 (3), 15601308 (1), 10080945 (1), 17975136 (1) (see all 8)
colon carcinoma	26.61	3	15601308 (1), 16357153 (1)
malignant glioma	20.66	7	9694158 (6)
colon cancer	17.58	2	15601308 (1), 10080945 (1)
prostate cancer	15.09	9	15906275 (3), 18196534 (1), 14766760 (1), 15001534 (1) (see all 6)
leukaemia lymphocytic	14.16	1	15452117 (1)

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Genetic Association Database: FADD
Human Genome Epidemiology Navigator: FADD (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/408 PubMed articles for FADD gene (see all 408 ):

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. (PubMed id 7536190)^{2, 3, 4} Boldin M.P....Wallach D. (1995)
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. (PubMed id 7538907)^{2, 3, 4} Chinnaiyan A.M....Dixit V.M. (1995)
NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. (PubMed id 9582077)^{1, 3, 4} Eberstadt M.... Fesik S.W. (1998)
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. (PubMed id 12702765)^{1, 3, 4} Screaton R.A.... Frisch S.M. (2003)
PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1- induced apoptosis. (PubMed id 10442631)^{1, 3, 4} Condorelli G.... Beguinot F. (1999)
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. (PubMed id 16127453)^{3, 4} Kawai T.... Akira S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
LRDD, a novel leucine rich repeat and death domain containing protein. (PubMed id 10825539)^{3, 4} Telliez J.-B.... Lin L.-L. (2000)
FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2- terminal kinase activation. (PubMed id 11034606)^{3, 4} Rochat-Steiner V....Tschopp J. (2000)
The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain. (PubMed id 18632871)^{1, 3} Tungteakkhun S.S....Duerksen-Hughes P.J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8772	HGNC: 3573	AceView: FADD	Ensembl:ENSG00000168040	euGenes: HUgn8772
ECgene: FADD	H-InvDB: FADD

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FADD	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/fadd/

Licensable Technologies for FADD
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FADD:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FADD-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FADD		Antibodies for FADD
	Explore super-pooled esiRNAs		Proteins for FADD
	Lentivirus-delivered shRNAs for FADD		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FADD)
	Antibodies (FADD)
	Chimera RNAi (FADD)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FADD

	Recombinant Proteins (FADD)
	Antibodies (FADD)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for FADD

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FADD Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for FADD

Summaries
for FADD

Genomic Location
for FADD

Proteins
for FADD

Protein Domains/
Families
for FADD

Gene Function
for FADD

Pathways & Interactions
for FADD

Drugs & Compounds
for FADD

Transcripts
for FADD

Expression
for FADD

Orthologs
for FADD

Paralogs
for FADD

SNPs/Variants
for FADD

Disorders & Mutations
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Medical News
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Search for FADD

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Specialized Databases showing FADD

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Services
for FADD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FADD Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor FADD

Summariesfor FADD

Genomic Locationfor FADD

Proteinsfor FADD

Protein Domains/Familiesfor FADD

Gene Functionfor FADD

Pathways & Interactionsfor FADD

Drugs & Compoundsfor FADD

Transcriptsfor FADD

Expression for FADD

Orthologsfor FADD

Paralogsfor FADD

SNPs/Variantsfor FADD

Disorders & Mutationsfor FADD

Medical Newsfor FADD

Publicationsfor FADD

Search for FADD

Genome Databases showing FADD

Other Databases showing FADD

Specialized Databases showing FADD

Licensable Technologiesfor FADD

Servicesfor FADD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FADD

Summaries
for FADD

Genomic Location
for FADD

Proteins
for FADD

Protein Domains/
Families
for FADD

Gene Function
for FADD

Pathways & Interactions
for FADD

Drugs & Compounds
for FADD

Transcripts
for FADD

Expression
for FADD

Orthologs
for FADD

Paralogs
for FADD

SNPs/Variants
for FADD

Disorders & Mutations
for FADD

Medical News
for FADD

Publications
for FADD

Licensable Technologies
for FADD

Services
for FADD