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Aliases for FADD Gene

Aliases for FADD Gene

  • Fas (TNFRSF6)-Associated Via Death Domain 2 3
  • Growth-Inhibiting Gene 3 Protein 2 3 4
  • Fas-Associating Death Domain-Containing Protein 2 3
  • Fas-Associating Protein With Death Domain 2 3
  • Mediator Of Receptor-Induced Toxicity 2 3
  • Mediator Of Receptor Induced Toxicity 3 4
  • MORT1 3 4
  • FAS-Associating Death Domain-Containing Protein 4
  • FAS-Associated Death Domain Protein 3
  • Protein FADD 4
  • GIG3 3

External Ids for FADD Gene

Previous GeneCards Identifiers for FADD Gene

  • GC11P072381
  • GC11P071572
  • GC11P070271
  • GC11P069775
  • GC11P069726
  • GC11P070049
  • GC11P066308

Summaries for FADD Gene

Entrez Gene Summary for FADD Gene

  • The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

GeneCards Summary for FADD Gene

FADD (Fas (TNFRSF6)-Associated Via Death Domain) is a Protein Coding gene. Diseases associated with FADD include infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations and fadd-related immunodeficiency. Among its related pathways are Pathways in cancer and NF-KappaB Family Pathway. GO annotations related to this gene include identical protein binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for FADD Gene

  • Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Gene Wiki entry for FADD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FADD Gene

Genomics for FADD Gene

Regulatory Elements for FADD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FADD Gene

Start:
70,203,163 bp from pter
End:
70,207,402 bp from pter
Size:
4,240 bases
Orientation:
Plus strand

Genomic View for FADD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADD Gene

Proteins for FADD Gene

  • Protein details for FADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13158-FADD_HUMAN
    Recommended name:
    FAS-associated death domain protein
    Protein Accession:
    Q13158
    Secondary Accessions:
    • Q14866
    • Q6IBR4

    Protein attributes for FADD Gene

    Size:
    208 amino acids
    Molecular mass:
    23279 Da
    Quaternary structure:
    • Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and PIDD1. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).

    Three dimensional structures from OCA and Proteopedia for FADD Gene

neXtProt entry for FADD Gene

Proteomics data for FADD Gene at MOPED

Post-translational modifications for FADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FADD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FADD (FADD)

No data available for DME Specific Peptides for FADD Gene

Domains for FADD Gene

Protein Domains for FADD Gene

Suggested Antigen Peptide Sequences for FADD Gene

Graphical View of Domain Structure for InterPro Entry

Q13158

UniProtKB/Swiss-Prot:

FADD_HUMAN :
  • Q13158
Domain:
  • Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
  • The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
  • Contains 1 death domain.
  • Contains 1 DED (death effector) domain.
genes like me logo Genes that share domains with FADD: view

No data available for Gene Families for FADD Gene

Function for FADD Gene

Molecular function for FADD Gene

GENATLAS Biochemistry: Fas-associated DEATH domain protein (FADD/MORT1),23kDa,intracellular mediator of lymphocyte apoptosis,associating with the DEATH domain of TNFRSF6 and CASP8
UniProtKB/Swiss-Prot Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Gene Ontology (GO) - Molecular Function for FADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21785459
GO:0005123 death receptor binding IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 10442631
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with FADD: view
genes like me logo Genes that share phenotypes with FADD: view

Animal Models for FADD Gene

MGI Knock Outs for FADD:

Animal Model Products

CRISPR Products

miRNA for FADD Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FADD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FADD Gene

Localization for FADD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FADD Gene COMPARTMENTS Subcellular localization image for FADD gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 3
mitochondrion 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0031264 death-inducing signaling complex TAS 18309324
GO:0031265 CD95 death-inducing signaling complex IDA 20935634
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with FADD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FADD Gene

Pathways for FADD Gene

genes like me logo Genes that share pathways with FADD: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0002821 positive regulation of adaptive immune response ISS --
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with FADD: view

Compounds for FADD Gene

(21) Novoseek inferred chemical compound relationships for FADD Gene

Compound -log(P) Hits PubMed IDs
ceramide 52 6
cycloheximide 44.5 8
paclitaxel 21.1 6
cisplatin 19.7 7
actinomycin d 19.7 7
genes like me logo Genes that share compounds with FADD: view

Transcripts for FADD Gene

mRNA/cDNA for FADD Gene

(318) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FADD Gene

Fas (TNFRSF6)-associated via death domain:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FADD

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FADD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FADD Gene

No ASD Table

Relevant External Links for FADD Gene

GeneLoc Exon Structure for
FADD
ECgene alternative splicing isoforms for
FADD

Expression for FADD Gene

mRNA expression in normal human tissues for FADD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FADD Gene

This gene is overexpressed in Whole Blood (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FADD Gene

SOURCE GeneReport for Unigene cluster for FADD Gene Hs.86131

mRNA Expression by UniProt/SwissProt for FADD Gene

Q13158-FADD_HUMAN
Tissue specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes
genes like me logo Genes that share expressions with FADD: view

In Situ Assay Products

Orthologs for FADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for FADD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FADD 35
  • 98.88 (n)
  • 98.08 (a)
FADD 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FADD 35
  • 76.86 (n)
  • 66.99 (a)
FADD 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FADD 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fadd 35
  • 75.98 (n)
  • 69.12 (a)
Fadd 16
Fadd 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FADD 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fadd 35
  • 75.24 (n)
  • 68.93 (a)
chicken
(Gallus gallus)
Aves FADD 35
  • 55.49 (n)
  • 45.81 (a)
FADD 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FADD 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fadd 35
  • 56.21 (n)
  • 43.14 (a)
zebrafish
(Danio rerio)
Actinopterygii fadd 35
  • 50 (n)
  • 39.61 (a)
fadd 36
  • 34 (a)
OneToOne
Species with no ortholog for FADD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FADD Gene

ENSEMBL:
Gene Tree for FADD (if available)
TreeFam:
Gene Tree for FADD (if available)

Paralogs for FADD Gene

No data available for Paralogs for FADD Gene

Variants for FADD Gene

Sequence variations from dbSNP and Humsavar for FADD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4197 -- 70,207,017(-) CCACA(-/ACA)GCACC utr-variant-3-prime
rs1051422 -- 70,207,029(+) GGGGA(A/G)AGGCA utr-variant-3-prime
rs1131677 -- 70,203,417(+) GGCGC(A/G)CGGAG utr-variant-5-prime
rs1131715 -- 70,207,381(+) CCATA(C/T)TACAA utr-variant-3-prime
rs2230821 -- 70,206,245(+) AGATA(C/T)CCCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FADD Gene

Variant ID Type Subtype PubMed ID
esv268477 CNV Insertion 20981092

Relevant External Links for FADD Gene

HapMap Linkage Disequilibrium report
FADD
Human Gene Mutation Database (HGMD)
FADD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FADD Gene

Disorders for FADD Gene

(1) OMIM Diseases for FADD Gene (602457)

UniProtKB/Swiss-Prot

FADD_HUMAN
  • Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). {ECO:0000269 PubMed:21109225}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FADD Gene

(30) Novoseek inferred disease relationships for FADD Gene

Disease -log(P) Hits PubMed IDs
necrosis 66.8 27
autoimmune lymphoproliferative syndrome 65 1
tumors 56.1 30
leukemia 33.6 1
cancer 32.8 13

Relevant External Links for FADD

Genetic Association Database (GAD)
FADD
Human Genome Epidemiology (HuGE) Navigator
FADD
genes like me logo Genes that share disorders with FADD: view

Publications for FADD Gene

  1. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. (PMID: 9582077) Eberstadt M. … Fesik S.W. (Nature 1998) 3 4 23
  2. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1- induced apoptosis. (PMID: 10442631) Condorelli G. … Beguinot F. (Oncogene 1999) 3 4 23
  3. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. (PMID: 12702765) Screaton R.A. … Frisch S.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  4. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. (PMID: 19118384) Scott F.L. … Riedl S.J. (Nature 2009) 3 4 23
  5. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. (PMID: 7536190) Boldin M.P. … Wallach D. (J. Biol. Chem. 1995) 2 3 4

Products for FADD Gene

  • Addgene plasmids for FADD

Sources for FADD Gene

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