Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FADD Gene

protein-coding   GIFtS: 69
GCID: GC11P070049

Fas (TNFRSF6)-Associated Via Death Domain

  See FADD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fas (TNFRSF6)-Associated Via Death Domain1 2     Mediator Of Receptor Induced Toxicity2 3
FAS-Associating Death Domain-Containing Protein1 2 3     MORT12 3
Growth-Inhibiting Gene 3 Protein1 2 3     FAS-Associated Death Domain Protein2
Fas-Associating Protein With Death Domain1 2     Protein FADD3
Mediator Of Receptor-Induced Toxicity1 2     

External Ids:    HGNC: 35731   Entrez Gene: 87722   Ensembl: ENSG000001680407   OMIM: 6024575   UniProtKB: Q131583   

Export aliases for FADD gene to outside databases

Previous GC identifers: GC11P072381 GC11P071572 GC11P070271 GC11P069775 GC11P069726 GC11P066308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FADD Gene:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and
mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by
TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it
participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors
unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby
activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in
early T cell development. (provided by RefSeq, Jul 2008)

GeneCards Summary for FADD Gene:
FADD (Fas (TNFRSF6)-associated via death domain) is a protein-coding gene. Diseases associated with FADD include infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations, and microvascular complications of diabetes 4. GO annotations related to this gene include tumor necrosis factor receptor binding and identical protein binding.

UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158
Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1
receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8
proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of
interferon signaling

Gene Wiki entry for FADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FADD gene promoter:
         CREB   AML1a   deltaCREB   FOXO1a   Ik-3   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFADD promoter sequence
   Search Chromatin IP Primers for FADD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.3

FADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FADD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P070049:  view genomic region     (about GC identifiers)

Start:
70,049,269 bp from pter      End:
70,053,508 bp from pter
Size:
4,240 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158 (See protein sequence)
Recommended Name: FAS-associated death domain protein  
Size: 208 amino acids; 23279 Da
Subunit: Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex
containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. Interacts
(via death domain) with FAS (via death domain). Interacts with CASP8
Selected PDB 3D structures from and Proteopedia for FADD (see all 7):
1A1W (3D)        1A1Z (3D)        1E3Y (3D)        1E41 (3D)        2GF5 (3D)        3EZQ (3D)    
Secondary accessions: Q14866 Q6IBR4

Explore the universe of human proteins at neXtProt for FADD: NX_Q13158

Explore proteomics data for FADD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FADD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003815.1  
    ENSEMBL proteins: 
     ENSP00000301838  
    Reactome Protein details: Q13158

    FADD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FADD
    OriGene Protein Over-expression Lysate for FADD
    OriGene MassSpec for FADD
    OriGene Custom Protein Services for FADD
    GenScript Custom Purified and Recombinant Proteins Services for FADD
    Novus Biologicals FADD Proteins
    Novus Biologicals FADD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FADD
    Cloud-Clone Corp. Proteins for FADD

     
    Search eBioscience for Proteins for FADD 

     
    antibodies-online proteins for FADD (10 products) 

     
    antibodies-online peptides for FADD

    FADD Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FADD
    R&D Systems Antibodies for FADD
    Cell Signaling Technology (CST) Antibodies for FADD 
    OriGene Antibodies for FADD
    OriGene Custom Antibody Services for FADD
    Novus Biologicals FADD Antibodies
    Abcam antibodies for FADD
    Cloud-Clone Corp. Antibodies for FADD
    ThermoFisher Antibodies for FADD
    LSBio Antibodies in human, mouse, rat for FADD
    antibodies-online antibodies for FADD (196 products) 

    FADD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FADD
    R&D Systems Proteome Profiler Antibody Arrays for FADD
    GenScript Custom Assay Services for FADD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FADD
    Cloud-Clone Corp. CLIAs for FADD
    Search eBioscience for ELISAs for FADD 
    antibodies-online kits for FADD (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain
     IPR016729 FADD
     IPR001875 DED

    Graphical View of Domain Structure for InterPro Entry Q13158

    ProtoNet protein and cluster: Q13158

    2 Blocks protein domains:
    IPB000488 Death domain
    IPB001875 Death effector protein


    UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158
    Domain: Contains a death domain involved in the binding of the corresponding domain within Fas receptor
    Domain: The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing
    signaling complex (DISC)
    Similarity: Contains 1 death domain
    Similarity: Contains 1 DED (death effector) domain


    Find genes that share domains with FADD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FADD_HUMAN, Q13158
    Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1
    receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8
    proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
    Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of
    interferon signaling

         Genatlas biochemistry entry for FADD:
    Fas-associated DEATH domain protein (FADD/MORT1),23kDa,intracellular mediator of lymphocyte apoptosis,associating
    with the DEATH domain of TNFRSF6 and CASP8

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI9208847
    GO:0005123death receptor binding TAS7538907
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI10442631
    GO:0032813tumor necrosis factor receptor superfamily binding IPI--
         
    Find genes that share ontologies with FADD           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FADD:
     Cell cycle / mitosis defect  Decreased viability with pacli 

         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Fadd):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with FADD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FADD: Faddtm1Mak Faddtm1Wnt Faddtm1.1Mpa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FADD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FADD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FADD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FADD

    miRNA
    Products:
        
    miRTarBase miRNAs that target FADD:
    hsa-mir-146a-5p (MIRT000638), hsa-mir-7-5p (MIRT025869), hsa-mir-1 (MIRT023826), hsa-mir-15b-5p (MIRT046456)

    Block miRNA regulation of human, mouse, rat FADD using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FADD:
    hsa-miR-361-5p
    SwitchGear 3'UTR luciferase reporter plasmidFADD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FADD
    Predesigned siRNA for gene silencing in human, mouse, rat FADD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FADD

    Clone
    Products:
         
    OriGene clones in human, mouse for FADD (see all 6)
    OriGene ORF clones in mouse, rat for FADD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FADD (NM_003824)
    Sino Biological Human cDNA Clone for FADD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FADD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FADD
    Addgene plasmids for FADD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FADD
    Browse ESI BIO Cell Lines and PureStem Progenitors for FADD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADD

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-13075) for FADD 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    extracellular3
    mitochondrion3
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0031264death-inducing signaling complex TAS18309324
    GO:0031265CD95 death-inducing signaling complex IDA--
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with FADD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FADD About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.00
    RIG-I-like receptor signaling pathway0.47
    4Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival FAS signaling cascades0.44
    5Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44


    Find genes that share SuperPaths with FADD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FADD
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FADD (see all 23)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    TRAF Pathway
    Mitochondrial Apoptosis

    1 Cell Signaling Technology (CST) Pathway for FADD
        Apoptosis and Autophagy

    4 GeneGo (Thomson Reuters) Pathways for FADD
        Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for FADD (see all 16)
        Apoptosis
    Apoptosis Modulation and Signaling
    FAS pathway and Stress induction of HSP regulation
    Integrated Breast Cancer Pathway
    Toll-like receptor signaling pathway

    2 Sino Biological Pathways for FADD
        TNF Signaling
    Death Receptor Signaling

    Selected Reactome Pathways for FADD (see all 8)
        FasL/ CD95L signaling
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    TNF signaling
    TRIF-mediated programmed cell death
    Caspase-8 activation


    Selected Kegg Pathways  (Kegg details for FADD) (see all 10):
        Apoptosis
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    TNF signaling pathway
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FADD (see all 13): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FADD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FADD (Q131581, 2, 3 ENSP000003018384) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147901, 2, 3, ENSP000003512734EBI-494804,EBI-78060 MINT-4055344 MINT-4055373 I2D: score=10 STRING: ENSP00000351273
    CASP10Q928512, 3, ENSP000002861864MINT-16276 MINT-16275 I2D: score=6 STRING: ENSP00000286186
    TNFRSF10BO147632, 3, ENSP000002764314MINT-17413 I2D: score=5 STRING: ENSP00000276431
    TAB1Q157502, 3, ENSP000002161604MINT-8260097 I2D: score=2 STRING: ENSP00000216160
    MOB4Q9Y3A32, 3MINT-65827 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity ISS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0002821positive regulation of adaptive immune response ISS--
    GO:0006915apoptotic process TAS--

    Find genes that share ontologies with FADD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FADD

    Selected Novoseek inferred chemical compound relationships for FADD gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ceramide 52 6 10722705 (2), 10616904 (1), 16397504 (1), 16357153 (1) (see all 5)
    cycloheximide 44.5 11 10722705 (2), 10066786 (2), 19661440 (1), 18485876 (1) (see all 6)
    paclitaxel 21.1 11 15001534 (3), 15452117 (2), 17119350 (1)
    cisplatin 19.7 7 16009487 (2), 9840918 (1), 20202822 (1), 10397248 (1) (see all 6)
    actinomycin d 19.7 7 18543108 (4), 16538385 (3)
    sp 600125 15.5 1 15001534 (1)
    doxorubicin 9.15 3 12203125 (1), 10080945 (1), 17970047 (1)
    cysteine 8.84 2 8681377 (1), 10812970 (1)
    camptothecin 2.96 1 15634660 (1)
    cholesterol 0 1 12902349 (1)



    Find genes that share compounds with FADD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FADD gene: 
    NM_003824.3  

    Unigene Cluster for FADD:

    Fas (TNFRSF6)-associated via death domain
    Hs.86131  [show with all ESTs]
    Unigene Representative Sequence: NM_003824
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301838(uc001opm.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FADD using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate FADD:
    hsa-miR-361-5p
    SwitchGear 3'UTR luciferase reporter plasmidFADD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FADD
    Predesigned siRNA for gene silencing in human, mouse, rat FADD
    Clone
    Products:
         
    OriGene clones in human, mouse for FADD (see all 6)
    OriGene ORF clones in mouse, rat for FADD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FADD (NM_003824)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FADD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FADD
    Addgene plasmids for FADD 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FADD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FADD
      QuantiTect SYBR Green Assays in human, mouse, rat FADD
      QuantiFast Probe-based Assays in human, mouse, rat FADD
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-13075) for FADD 

    Additional mRNA sequence: 

    AK291005.1 AK293320.1 AY423721.1 BC000334.2 BC025733.1 BT006927.1 CR456738.1 U24231.1 
    X84709.1 

    5 DOTS entries:

    DT.453779  DT.101975002  DT.100799955  DT.100799957  DT.120721306 

    Selected AceView cDNA sequences (see all 318):

    BG821754 CR593101 BQ896476 CK904421 CR595812 BQ686680 BQ688849 CF529895 
    BM797371 CR616686 BF982380 CR593331 CR615437 CF264787 BM817526 AA233608 
    CR591208 CR610334 CD513133 CR608391 BQ688047 BQ690011 CR596013 BG260182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FADD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGGGTGG
    FADD Expression
    About this image


    FADD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FADD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FADD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.86131

    UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158
    Tissue specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FADD (see all 13): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Liver Cancer in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FADD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FADD
    QuantiTect SYBR Green Assays in human, mouse, rat FADD
    QuantiFast Probe-based Assays in human, mouse, rat FADD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FADD gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fadd1 , 5 Fas (TNFRSF6)-associated via death domain1, 5 75.98(n)1
    69.12(a)1
      7 (88.85 cM)5
    140821  NM_010175.51  NP_034305.11 
     1445773185 
    chicken
    (Gallus gallus)
    Aves FADD1 Fas (TNFRSF6)-associated via death domain 55.49(n)
    45.81(a)
      423146  XM_421073.4  XP_421073.2 
    lizard
    (Anolis carolinensis)
    Reptilia FADD6
    Fas (TNFRSF6)-associated via death domain
    40(a)
    1 ↔ 1
    GL343283.1(80382-81072)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fadd1 Fas (TNFRSF6)-associated via death domain 56.21(n)
    43.14(a)
      100379789  XM_002934068.2  XP_002934114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fadd1 Fas (tnfrsf6)-associated via death domain 50(n)
    39.61(a)
      562317  XM_001923858.4  XP_001923893.1 


    ENSEMBL Gene Tree for FADD (if available)
    TreeFam Gene Tree for FADD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FADD (see all 162)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0651244
    Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM)4--see VAR_0651242 C W mis40--------
    rs346428861,2
    C--66310970(+) AGCTG-/CGGGAG 1 -- int10--------
    rs113705441,2
    C--66311798(+) TGGTGA/-CAGCC 1 -- int17Minor allele frequency- -:0.20NS CSA 184
    rs41971,2
    C--66312844(-) CCACAACA/-GCACC 1 -- cds110Minor allele frequency- -:0.38EU NA EA NS CSA 496
    rs3681932131,2
    C--66312845(+) GTGCT-/TGTGTGGT 1 -- cds10--------
    rs788793921,2
    --66312848(+) GCTGTG/TGTGGG 1 -- ut310--------
    rs1861910561,2
    --69892165(+) CCTCCA/GATGAA 1 -- us2k10--------
    rs71098311,2
    C,F,A,H--69892222(+) atgcaG/Tccata 1 -- us2k128Minor allele frequency- T:0.43NS EA NA WA CSA 2535
    rs348823001,2
    C,F--69892236(+) AGGAAG/AGAGGC 1 -- us2k18Minor allele frequency- A:0.03NA NS 186
    rs412681951,2
    C,F--69892338(+) CAACAT/GGGCAA 1 -- us2k15Minor allele frequency- G:0.01NS 180

    HapMap Linkage Disequilibrium report for FADD (70049269 - 70053508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FADD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268477CNV Insertion20981092

    Human Gene Mutation Database (HGMD): FADD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FADD
    DNA2.0 Custom Variant and Variant Library Synthesis for FADD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602457   
    OMIM disorders: 613759  
    UniProtKB/Swiss-Prot: FADD_HUMAN, Q13158
  • Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular
    malformations (IEHDCM) [MIM:613759]: A condition with biological features of autoimmune lymphoproliferative
    syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels.
    Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver
    dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster
    virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for FADD:    
    About MalaCards
    infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations    microvascular complications of diabetes 4    oral cavity cancer    oculootodental syndrome
    japanese encephalitis    autoimmune lymphoproliferative syndrome    oral leukoplakia

    2 diseases from the University of Copenhagen DISEASES database for FADD:
    Cancer     Autoimmune lymphoproliferative syndrome

    Find genes that share disorders with FADD           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FADD gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 66.8 29 16289096 (2), 18946037 (2), 10952991 (2), 16424911 (1) (see all 24)
    autoimmune lymphoproliferative syndrome 65 1 8955195 (1)
    tumors 56.1 36 19415536 (2), 10952991 (2), 8955195 (1), 15991280 (1) (see all 28)
    leukemia 33.6 1 12506034 (1)
    cancer 32.8 17 15906275 (3), 15601308 (1), 19479204 (1), 10080945 (1) (see all 11)
    colon carcinoma 24.8 3 15601308 (1), 16357153 (1)
    prostate cancer 24.3 15 19955841 (4), 15906275 (3), 18196534 (1), 14766760 (1) (see all 7)
    colon cancer 18.9 2 15601308 (1), 10080945 (1)
    malignant glioma 18.2 7 9694158 (6)
    carcinoma squamous cell 13.1 5 17975136 (1), 20438666 (1), 17425843 (1)

    Genetic Association Database (GAD): FADD
    Human Genome Epidemiology (HuGE) Navigator: FADD (10 documents)

    Export disorders for FADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FADD gene, integrated from 10 sources (see all 530):
    (articles sorted by number of sources associating them with FADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. (PubMed id 7536190)1, 2, 3 Boldin M.P....Wallach D. (J. Biol. Chem. 1995)
    2. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. (PubMed id 7538907)1, 2, 3 Chinnaiyan A.M.... Dixit V.M. (Cell 1995)
    3. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. (PubMed id 9582077)1, 2, 9 Eberstadt M.... Fesik S.W. (Nature 1998)
    4. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. (PubMed id 12702765)1, 2, 9 Screaton R.A.... Frisch S.M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    5. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. (PubMed id 19118384)1, 2, 9 Scott F.L.... Riedl S.J. (Nature 2009)
    6. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1- induced apoptosis. (PubMed id 10442631)1, 2, 9 Condorelli G.... Beguinot F. (Oncogene 1999)
    7. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    8. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    9. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    10. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. (PubMed id 20935634)1, 2 Wang L.... Wu H. (Nat. Struct. Mol. Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8772 HGNC: 3573 AceView: FADD Ensembl:ENSG00000168040 euGenes: HUgn8772
    ECgene: FADD Kegg: 8772 H-InvDB: FADD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FADD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FADD Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fadd/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FADD gene:
    Search GeneIP for patents involving FADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of FADD
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for FADD (FADD)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for FADD (FADD)  
     OriGene Antibodies for FADD   OriGene RNAi products in human, mouse, rat for FADD  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FADD  
     OriGene MassSpec for FADD   OriGene clones in human, mouse for FADD  
     OriGene qSTAR qPCR primer pairs in human, mouse for FADD   OriGene Purified Protein for FADD  
     OriGene ORF clones in mouse, rat for FADD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FADD   OriGene Custom Protein Services for FADD  

     
     
     Block miRNA regulation of human, mouse, rat FADD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FADD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FADD Predesigned siRNA for gene silencing in human, mouse, rat FADD
     QuantiFast Probe-based Assays in human, mouse, rat FADD QuantiTect SYBR Green Assays in human, mouse, rat FADD
     PCR Arrays including human, mouse, rat FADD Search Chromatin IP Primers for FADD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FADD  GeneGlobe Interaction Network for FADD
     Regulatory tfbs in FADD promoter
     GenScript Custom Purified and Recombinant Proteins Services for FADD GenScript cDNA clones with any tag delivered in your preferred vector for FADD
     GenScript Custom Assay Services for FADD GenScript Custom overexpressing Cell Line Services for FADD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FADD 

     Search Tocris compounds for FADD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FADD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FADD antibodies
     FADD proteins
     FADD lysates
     Antibodies for FADD
     See all of Abcam's Antibodies, Kits and Proteins for FADD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FADD
     Proteins for FADD
     Antibodies for FADD
     ELISAs for FADD
     CLIAs for FADD



     Browse ESI BIO Cell Lines and PureStem Progenitors for FADD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FADD
     SwitchGear 3'UTR luciferase reporter plasmids for FADD
     SwitchGear Promoter luciferase reporter plasmids for FADD
     ThermoFisher Antibodies for FADD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FADD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FADD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FADD
     LSBio Antibodies in human, mouse, rat for FADD
     Browse compounds at ApexBio
     Addgene plasmids for FADD
      Search eBioscience for proteins for FADD
      Search eBioscience for elisas for FADD
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for FADD (196 products)
     antibodies-online kits for FADD (9 products)
     antibodies-online peptides for FADD
     antibodies-online proteins for FADD (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FADD gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4