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FANCC Gene

protein-coding GIFtS: 66

GC09M096901

Fanconi anemia, complementation group C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FACC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FA3 ^¹, ²
FAC ^¹, ², ³
FACC ^², ³, ⁵
FLJ14675 ^²
OTTHUMP00000021706 ^²
OTTHUMP00000021707 ^²

Descriptions
Fanconi anemia, complementation group C ^²
Protein FACC ^³
bA80I15.1 (Fanconi anemia, complementation group C, protein) ^²

External Ids
HGNC: 3584¹
Entrez Gene: 2176²
UniProtKB: Q00597³
Ensembl: ENSG00000158169⁷

Search outside databases for aliases for FANCC gene

Previous GC identifers: GC09M088680 GC09M089589 GC09M091160 GC09M093202 GC09M094940

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FANCC:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1

(also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM

and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi

anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability,

hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA

repair. The members of the Fanconi anemia complementation group do not share sequence similarity;

they are related by their assembly into a common nuclear protein complex. This gene encodes the

protein for complementation group C. [provided by RefSeq]

UniProtKB/Swiss-Prot: FANCC_HUMAN, Q00597

Function: DNA repair protein that may operate in a postreplication repair or a cell cycle

checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance

of normal chromosome stability

Gene Wiki entry for FANCC (Fanconi_anemia%2C_complementation_group_C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FANCC gene

Entrez Gene cytogenetic band: 9q22.3 Ensembl cytogenetic band: 9q22.32 HGNC cytogenetic band: 9q22.3

FANCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M096901: (about GC identifiers)

Start:	96,901,157 bp from pter
End:	97,119,812 bp from pter
Size:	218,656 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FANCC_HUMAN, Q00597 (See protein sequence)

Recommended Name: Fanconi anemia group C protein

Size: 558 amino acids; 63429 Da

Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF,

FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. Interacts with ZBTB32

Subcellular location: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is

cytoplasmic

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000127.2

ENSEMBL proteins:

ENSP00000289081 ENSP00000364454 ENSP00000378754

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FANCC)
	Human Recombinant Proteins from Abnova (FANCC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9398857
GO:0005737	cytoplasm	TAS	9398857
GO:0005829	cytosol	IDA	9596688

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Antibodies for FANCC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FANCC
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FANCC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FANCC)
	Novus Biologicals Antibodies for FANCC

Assays for FANCC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q00597

ProtoNet protein and cluster: Q00597

1 Blocks protein family: IPB000686 Fanconi anaemia group C protein signature

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FANCC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FANCC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000136

Applied Biosystems Silencer® siRNAs for FANCC

Sigma-Aldrich siRNA for FANCC

Sigma-Aldrich shRNA Panels and shRNA for FANCC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FANCC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000136
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000136
untagged cDNA clone in CMV expression vector: NM_000136

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000136

UniProtKB/Swiss-Prot: FANCC_HUMAN, Q00597

Function: DNA repair protein that may operate in a postreplication repair or a cell cycle

checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance

of normal chromosome stability

Genatlas biochemistry entry for FANCC:

gene controlling the correct functioning of the replicative,repair and recombination

machineries,involved in the fidelity of end-joining of specific double strand break in the

cytoplasmic defense against a specific class of genotoxic agents and in the repair of oxidatively

damaged DNA

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fancc):

cellular

endocrine/exocrine gland

hematopoietic system

reproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	9596688

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for FANCC (Your Favorite Gene powered by Ingenuity)

Role of BRCA1 in DNA Damage Response

GeneDecks FANCC for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FANCC

5/32 Interacting proteins for FANCC (Q00597² ENSP00000364454³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCA	O15360², ENSP00000373952³	MINT-19439 MINT-19445 STRING (score=.999)
FANCE	Q9HB96², ENSP00000229769³	MINT-19451 MINT-19450 STRING (score=.999)
HSP90B1	P14625², ENSP00000299767³	MINT-19438 STRING (score=.947)
SPTAN1	Q13813², ENSP00000361806³	MINT-19443 STRING (score=.914)
CDC2	P06493², ENSP00000362917³	MINT-19437 STRING (score=.821)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	TAS	1574115
GO:0006461	protein complex assembly	TAS	9398857
GO:0006974	response to DNA damage stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FANCC
2 Novoseek chemical compound relationships for FANCC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diepoxybutane	78.59	3	8978774 (1), 10783335 (1)
oxygen	0.00	1	10783335 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FANCC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FANCC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000136

Sigma-Aldrich siRNA for FANCC

Sigma-Aldrich shRNA Panels and shRNA for FANCC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000136

REFSEQ mRNAs for FANCC gene:

NM_000136.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000136

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000136
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000136
                                 untagged cDNA clone in CMV expression vector: NM_000136

Additional cDNA sequence:

AK222871.1 AK304887.1 AK310599.1 AK312548.1 BC015748.1 CR593180.1 X66893.1 X66894.1

13 DOTS entries:

DT.313375 DT.95162350 DT.100706227 DT.100813029 DT.97769226 DT.40126275 DT.100813030 DT.121205235

DT.121205493 DT.121205515 DT.75169691 DT.91703847 DT.97798713

12 AceView cDNA sequences:

BX115735 BX509096 BC041030 BC006303 CA842814 CA848758 H94332 BF311482

BF207305 AF039185 AI591051 H94420

highest scoring ESTs for FANCC:

X66893 BG822505 AL702060 AU132608 BC015748 BM467064 BX403004 AA759063 AI218842 AI219504

Unigene Cluster for FANCC:

Fanconi anemia, complementation group C

Hs.494529 [show with all ESTs]

Unigene Representative Sequence: NM_000136

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000289081 ENST00000375305 ENST00000395345

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FANCC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FANCC

¹ / ² / ³

9 probe-sets matching FANCC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
72202_f_at²^{, 3}	U95-D	1	1.00	1.00	0.93	1.60	AI417754	0.20	1.00	0.72	1
35713_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.80	X66894	0.80	0.80	0.80	1
160034_s_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.69	X66893	1.00	0.90	0.95	1
53834_at²^{, 3}	U95-C	1	0.69	1.00	0.61	0.48	AI280997	0.60	1.00	0.82	1
205189_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000136	0.60	1.00	0.82	1
242654_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AF039185	0.40	1.00	0.76	1
1559513_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205189_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242654_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks FANCC for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGTAAAAC

SOURCE GeneReport for Unigene cluster: Hs.494529
Expression variation in blood from EXPOLDB for FANCC
UniProtKB/Swiss-Prot: FANCC_HUMAN, Q00597
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FANCC gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FANCC¹	--	Fanconi anemia, complementation group C	84.06(n) 77.08(a)	607277 XM_843898.1 XP_848991.1
chimpanzee (Pan troglodytes)	FANCC¹	--	Fanconi anemia, complementation group C	99.4(n) 99.1(a)	465257 XM_001150918.1 XP_001150918.1
cow (Bos taurus)	FANCC¹	--	Fanconi anemia, complementation group C	82.25(n) 74.73(a)	281762 NM_174316.2 NP_776741.1
rat (Rattus norvegicus)	Fancc¹	--	Fanconi anemia, complementation group C	77.36(n) 66.67(a)	24361 NM_012557.1 NP_036689.1
mouse (Mus musculus)	Fancc^{1, 5}	13 (36.00 cM)⁵	Fanconi anemia, complementation group C^{1, 5}	78.14(n)¹ 68.47(a)¹	14088¹ NM_007985.2¹ NP_032011.2¹ AK035488⁵ AK042226⁵ (see all 16)

About this table Species with no ortholog for FANCC

ENSEMBL Gene Tree for FANCC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1010 NCBI SNPs in FANCC are shown (see all 1010 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 279)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4647554^1,2	A,C,F,H	96902522(-)	`AGAAGC/TTAACC`	1	--	ut3¹		12	NS EA NA EU WA	1078
	rs1800362^1,2	C,F,H,O	96974180(-)	`TCTTGG/AGTATG`	1	E/G	mis¹ ese³		12	NS EU EA WA NA	1158
	rs4647558^1,2	A,C,F,H	96901939(-)	`TGGAAG/AACTTC`	1	--	ut3¹ ese³		5	NS EU EA WA	598
	rs4647556^1,2	C,F,H	96902148(-)	`TGTGAC/TTCCTC`	1	--	ut3¹ ese³		7	NS EA WA NA	614
	rs4647559^1,2	C,F,H	96901725(-)	`CCCAGC/ACTGAG`	1	--	ut3¹ ese³		8	NS EU EA WA NA	738
	rs1800367^1,2	C,F,H	96909357(-)	`AGGCCG/ATGCTG`	1	M/V	mis¹ ese³		7	NS WA NA EU EA	736
	rs9673^1,2	C,F,H	96901258(-)	`TGTTAT/CTCCCC`	1	--	ut3¹ ese³		13	NS MN NA EU EA WA	1340
	rs4647551^1,2	C,F,H	96903451(-)	`ATTCAA/GAGTCT`	1	--	ut3¹		12	NS EU EA WA NA	1128
	rs7048910^1,2	F,H	96903694(+)	`CATTCT/GCACAG`	1	--	ut3¹		4	EU EA WA	420
	rs4647557^1,2	F,H	96902083(-)	`CCTCCT/AGTTGT`	1	--	ut3¹ ese³		2	NS EU	300

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HapMap Linkage Disequilibrium images for FANCC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 227645

UniProtKB/Swiss-Prot: FANCC_HUMAN, Q00597

Defects in FANCC are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically

heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse

assortment of congenital malformations, and a predisposition to the development of malignancies.

At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal

instability (increased chromosome breakage), and defective DNA repair

10/16 Novoseek disease relationships for FANCC gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fanconis anemia	97.51	50	8621788 (3), 12239156 (3), 8058745 (3), 11433346 (2) (see all 30)
congenital malformation	52.42	1	8789444 (1)
cancer	45.12	4	15277238 (1), 8621788 (1), 12351379 (1), 17909071 (1)
anemia	43.27	9	7853372 (2), 12670332 (2), 7829076 (1), 16170343 (1) (see all 7)
aplasia	38.21	3	10515453 (1), 12351814 (1)
hnscc	31.09	2	17409780 (1), 16466850 (1)
pancreatic cancer	31.04	11	14726700 (5), 15277238 (1), 15107617 (1), 12750283 (1) (see all 5)
ataxia telangiectasia	27.69	1	17277230 (1)
chromosomal aberrations	24.49	1	8978774 (1)
breast cancer	21.52	4	17909071 (1), 14695169 (1), 18990233 (1)

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Genatlas disease: FANCC

Fanconi anemia,autosomal recessive,complementation group C,characterized by progressive bone

marrow failure (pancytopenia),often associated with skeletal abnormalities,radial hypoplasia and

vertebral defect and an increased cancer risk with spontaneous chromosomal breakage exacerbated by

exposure to DNA cross-linking agents

GeneTests: FANCC

Fanconi Anemia

Human Gene Mutation Database: FANCC
Genetic Association Database: FANCC
Human Genome Epidemiology Navigator: FANCC (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/162 PubMed articles for FANCC gene (see all 162 ):

A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. (PubMed id 10572087)^{1, 3, 4} Hoatlin M.E.... Licht J.D. (1999)
Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells. (PubMed id 8058745)^{1, 3, 4} Youssoufian H. (1994)
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. (PubMed id 16116422)^{3, 4} Meetei A.R....Wang W. (2005)
Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development. (PubMed id 15726604)^{3, 6} Koren-Michowitz M....Amariglio N. (2005)
Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. (PubMed id 15695377)^{3, 6} Couch F.J....Petersen G. (2005)
X-linked inheritance of Fanconi anemia complementation group B. (PubMed id 15502827)^{3, 4} Meetei A.R....Joenje H. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. (PubMed id 12724401)^{3, 4} Meetei A.R.... Wang W. (2003)
Bloom syndrome and Fanconi's anemia: rate and ethnic origin of mutation carriers in Israel. (PubMed id 11876000)^{3, 6} Peleg L....Barkai G. (2002)
Novel mutations and polymorphisms in the Fanconi anemia group C gene. (PubMed id 8844212)^{3, 4} Gibson R.A.... Mathew C.G. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2176	HGNC: 3584	AceView: FANCC.1	Ensembl:ENSG00000158169	euGenes: HUgn2176
ECgene: FANCC	H-InvDB: FANCC

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FANCC	Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database	http://www.rockefeller.edu/fanconi/mutate/jumpc.html
GeneReviews	http://www.genetests.org/query?gene=FANCC
NIEHS-SNPs	http://egp.gs.washington.edu/data/fancc/

Licensable Technologies for FANCC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FANCC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FANCC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FANCC		Antibodies for FANCC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FANCC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FANCC)
	Antibodies (FANCC)
	Chimera RNAi (FANCC)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FANCC)
	Antibodies (FANCC)

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FANCC Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for FANCC

Summaries
for FANCC

Genomic Location
for FANCC

Proteins
for FANCC

Protein Domains/
Families
for FANCC

Gene Function
for FANCC

Pathways & Interactions
for FANCC

Drugs & Compounds
for FANCC

Transcripts
for FANCC

Expression
for FANCC

Orthologs
for FANCC

Paralogs
for FANCC

SNPs/Variants
for FANCC

Disorders & Mutations
for FANCC

Medical News
for FANCC

Publications
for FANCC

Search for FANCC

Genome Databases showing FANCC

Other Databases showing FANCC

Specialized Databases showing FANCC

Licensable Technologies
for FANCC

Services
for FANCC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FANCC Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor FANCC

Summariesfor FANCC

Genomic Locationfor FANCC

Proteinsfor FANCC

Protein Domains/Familiesfor FANCC

Gene Functionfor FANCC

Pathways & Interactionsfor FANCC

Drugs & Compoundsfor FANCC

Transcriptsfor FANCC

Expression for FANCC

Orthologsfor FANCC

Paralogsfor FANCC

SNPs/Variantsfor FANCC

Disorders & Mutationsfor FANCC

Medical Newsfor FANCC

Publicationsfor FANCC

Search for FANCC

Genome Databases showing FANCC

Other Databases showing FANCC

Specialized Databases showing FANCC

Licensable Technologiesfor FANCC

Servicesfor FANCC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FANCC

Summaries
for FANCC

Genomic Location
for FANCC

Proteins
for FANCC

Protein Domains/
Families
for FANCC

Gene Function
for FANCC

Pathways & Interactions
for FANCC

Drugs & Compounds
for FANCC

Transcripts
for FANCC

Expression
for FANCC

Orthologs
for FANCC

Paralogs
for FANCC

SNPs/Variants
for FANCC

Disorders & Mutations
for FANCC

Medical News
for FANCC

Publications
for FANCC

Licensable Technologies
for FANCC

Services
for FANCC