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FABP7 Gene

protein-coding   GIFtS: 59

GC06P123142
fatty acid binding protein 7, brain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
B-FABP 1, 2, 3
BLBP 1, 2, 3
DKFZp547J2313 2
FABPB 2, 3
MRG 2, 3
OTTHUMP00000017118 2
Descriptions
Brain lipid-binding protein 3
Fatty acid-binding protein 7 3
Mammary-derived growth inhibitor related 3
brain lipid binding protein 2
fatty acid binding protein 7, brain 2
mammary-derived growth inhibitor-related 2
External Ids
HGNC: 35621
Entrez Gene: 21732
UniProtKB: O155403
Ensembl: ENSG000001644347
Search outside databases for aliases for FABP7 gene

Previous GC identifers: GC06P122871 GC06P123058 GC06P123035 GC06P123081

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FABP7:
The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins
(FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty
acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake,
transport, and metabolism. [provided by RefSeq]

UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540
Function: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with
potential morphogenic activity during CNS development. It is required for the establishment of the
radial glial fiber system in developing brain, a system that is necessary for the migration of
immature neurons to establish cortical layers (By similarity)

Gene Wiki entry for FABP7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FABP7 gene  

Entrez Gene cytogenetic band: 6q22-q23   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22-q23

FABP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P123142:     (about GC identifiers)

Start:
123,142,345 bp from pter
End:
123,146,918 bp from pter
Size:
4,574 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540 (See protein sequence)
Recommended Name: Fatty acid-binding protein, brain  
Size: 132 amino acids; 14889 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1FDQ (3D)    1FE3 (3D)    1JJX (3D)    
Secondary accessions: O14951 Q6IAU7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001437.1  

    ENSEMBL proteins: 
    ENSP00000357429 ENSP00000348931 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BLBP)
    Human Recombinant Proteins from Abnova (FABP7)
                  OriGene Purified Recombinant Human Protein: FABP7 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for FABP7: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of FABP7
    Sigma-Aldrich Antibodies for FABP7
    R&D Systems Antibodies for FABP7
    Antibodies from Abcam (BLBP), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FABP7)
    Novus Biologicals Antibodies for FABP7

    Assays for FABP7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR000463 Fatty_acid_bd
     IPR012674 Calycin
     IPR000566 Lipocln_cytFABP


       GeneDecks  FABP7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15540

    ProtoNet protein and cluster: O15540

    1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FABP7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FABP7)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001446

                  Applied Biosystems Silencer® siRNAs for FABP7

                  Sigma-Aldrich siRNA for FABP7  
                         Sigma-Aldrich shRNA for FABP7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FABP7
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001446
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001446
                                     untagged cDNA clones in CMV expression vector (see all 2): AL512688 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: AL512688

    UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540
    Function: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with
    potential morphogenic activity during CNS development. It is required for the establishment of the
    radial glial fiber system in developing brain, a system that is necessary for the migration of
    immature neurons to establish cortical layers (By similarity)

    1 MGI phenotypic allele for Fabp7 (no phenotypes)


    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215 transporter activity IEA--
    GO:0008289 lipid binding TAS9375786
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for FABP7
     Transcription factors in neurogenesis

       GeneDecks  FABP7 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  FABP7  (Your Favorite Gene powered by Ingenuity) 
     LPS/IL-1 Mediated Inhibition of RXR Function

       GeneDecks  FABP7 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for FABP7):
     hsa03320 PPAR signaling pathway

       GeneDecks  FABP7 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  FABP7 


    5/13 Interacting proteins for FABP7 (ENSP000003489313) via UniProtKB, MINT, and/or STRING (see all 13 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOTCH1ENSP000003607653STRING (score=.963)
    PAX6ENSP000003684243STRING (score=.941)
    FABP6ENSP000003122833STRING (score=.872)
    FABP1ENSP000002958343STRING (score=.838)
    GOT2ENSP000002452063STRING (score=.829)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport IEA--
    GO:0007399 nervous system development TAS9375786
    GO:0008285 negative regulation of cell proliferation TAS9250612
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FABP7
    5 Novoseek chemical compound relationships for FABP7 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 55.37 18 12479569 (2), 18826602 (2), 18391847 (2), 9591779 (1) (see all 14)
    docosahexaenoic acid 47.84 12 10854433 (3), 8798739 (2), 11103817 (2)
    lipid 33.62 21 12612091 (2), 15622533 (1), 18593473 (1), 18826602 (1) (see all 14)
    oleic acid 22.51 4 8798739 (1), 10854433 (1)
    arachidonic acid 3.73 3 8798739 (1), 10854433 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FABP7)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FABP7)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001446

                  Sigma-Aldrich siRNA for FABP7  
                         Sigma-Aldrich shRNA for FABP7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001446  

    REFSEQ mRNAs for FABP7 gene: 

    NM_001446.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001446  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001446
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001446
                                     untagged cDNA clones in CMV expression vector (see all 2): AL512688 

    Additional cDNA sequence: 

    AB208815.1 AJ002962.1 AK289836.1 AK307272.1 AK311867.1 AL512688.1 BC012299.1 CR457057.1 
    D50373.1 D88648.1 U51338.1 U81235.1 

    5 DOTS entries:

    DT.313655  DT.40110554  DT.91736342  DT.91744417  DT.121347539 

    24/104 AceView cDNA sequences (see all 104 ):

    AW162191 AI878887 AI879439 AV718267 AW157160 BX113553 BM698823 AI929618 
    AW163440 AL512688 NM_001446 AI929340 BX461253 D88648 AW163515 BM668866 
    AJ002962 AW160409 AI652178 BU736791 U81235 AI369673 CR457057 BI544779 

    highest scoring ESTs for FABP7:

    AJ002962 AA029795 AA194097 AA340117 AA436624 AA483611 AA513170 AA648648 AA776582 AI131159 

    Unigene Cluster for FABP7:

    Fatty acid binding protein 7, brain
    Hs.26770  [show with all ESTs]
    Unigene Representative Sequence: AB208815


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000368444  ENST00000356535  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FABP7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FABP7

    1 / 2 / 3

    7 probe-sets matching FABP7 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35185_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AJ002962 1.00 1.00 1.00 1

    205030_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001446 0.60 1.00 0.82 1

    216192_at2, 3 U133-A 1 1.00 1.00 -- -- AL512688 0.60 1.00 0.82 1

    205029_s_at2, 3 U133-A 2 1.00 0.91 -- -- NM_001446 0.60 1.00 0.82 1

    205030_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    216192_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    205029_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    GeneDecks  FABP7 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTTATAATT

    SOURCE GeneReport for Unigene cluster: Hs.26770

    Expression variation in blood from EXPOLDB for FABP7

    UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540
    Tissue specificity: Expressed in brain and other neural tissues

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FABP7 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FABP71   -- fatty acid binding protein 7, brain 92.68(n)
    94.7(a)
    476278  XM_533484.2  XP_533484.2 
    chimpanzee
    (Pan troglodytes)
    FABP71   -- fatty acid binding protein 7, brain 99.75(n)
    99.24(a)
    472116  XM_527495.2  XP_527495.1 
    cow
    (Bos taurus)
    FABP71   -- fatty acid binding protein 7, brain 91.92(n)
    95.45(a)
    777787  XM_001249630.1  XP_001249631.1 
    rat
    (Rattus norvegicus)
    Fabp71   -- fatty acid binding protein 7, brain 86.62(n)
    88.64(a)
    80841  NM_030832.1  NP_110459.1 
    mouse
    (Mus musculus)
    Fabp71, 5 105
    fatty acid binding protein 7, brain1, 5 85.35(n)1
    87.12(a)1
    121401  NM_021272.31  NP_067247.11 
     AJ8709705  AK0029555  (see all 11)
    About this table        Species with no ortholog for FABP7

    ENSEMBL Gene Tree for FABP7
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FABP7 gene
    FABP32  FABP5L82  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/58 NCBI SNPs in FABP7 are shown (see all 58 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 53)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs77742711,2
    A,C,F,H123141770(+) AGGAGG/ATCGGG 1 -- ng51 tfbs34Minor allele frequency- A:0.06EU EA WA 416
    rs22793811,2
    C,F,H123143243(-) TCTCCG/ATGTTC 1 M/T mis1 ese312Minor allele frequency- A:0.03EA NA EU WA 2468
    rs77698911,2
    A,H123141248(+) ACACCG/AAAGAA 1 -- ng514Minor allele frequency- A:0.00EU EA WA 416
    rs121943771,2
    F,H123141681(+) AATCAA/GAAGGT 1 -- ng513Minor allele frequency- G:0.01EA WA 272
    rs31027541,2
    H123147179(-) CACTTC/TCGTAG 1 -- ng314Minor allele frequency- T:0.00EU EA WA 420
    --
    rs77690991,2
    A123140881(+) atttaC/Tgtttt 1 -- ng51 tfbs30--------
    --
    rs37634951,2
    C123147375(-) tggtcA/Gacacg 1 -- ng310--------
    --
    rs77692611,2
    A123141000(+) ttgctC/Tatatt 1 -- ng510--------
    --
    rs77692881,2
    A123141088(+) CATTAA/GGTTTG 1 -- ng510--------
    --
    rs77692371,2
    A123140861(+) tgtatG/Tccttc 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for FABP7 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602965

    6 Novoseek disease relationships for FABP7 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 40.17 21 10896661 (6), 17898869 (4), 9591779 (3)
    tumors 10.86 11 11103817 (2), 17898869 (2), 17083565 (2), 9591779 (1) (see all 8)
    carcinoma renal cell 8.32 3 17083565 (2), 17320655 (1)
    breast carcinoma 8.10 2 9242429 (2)
    breast cancer 6.11 11 9242429 (4), 11103817 (2), 9731516 (1)
    hyperplasia 0.00 1 9242429 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/75 PubMed articles for FABP7 gene (see all 75 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2173 HGNC: 3562 AceView: FABP7 Ensembl:ENSG00000164434 euGenes: HUgn2173
    ECgene: FABP7 H-InvDB: FABP7
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FABP7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for FABP7 Antibodies for FABP7
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FABP7 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
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     Recombinant Proteins
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for FABP7




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FABP7

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