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Aliases & Descriptions for FABP7
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B-FABP 1, 2, 3 | | BLBP 1, 2, 3 | | DKFZp547J2313 2 | | FABPB 2, 3 | | MRG 2, 3 | | OTTHUMP00000017118 2 |
| | | Descriptions |
|---|
| Brain lipid-binding protein 3 | | Fatty acid-binding protein 7 3 | | Mammary-derived growth inhibitor related 3 | | brain lipid binding protein 2 | | fatty acid binding protein 7, brain 2 | | mammary-derived growth inhibitor-related 2 |
|
| | Search outside databases for aliases for FABP7 genePrevious GC identifers: GC06P122871 GC06P123058 GC06P123035 GC06P123081 |
Summaries for FABP7(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FABP7: The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq] UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540Function: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity)Gene Wiki entry for FABP7 |
Genomic Location for FABP7
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FABP7 gene 
Entrez Gene cytogenetic band: 6q22-q23 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q22-q23FABP7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P123142:
(about GC identifiers)
Start:
|
123,142,345 bp from pter |
End:
|
123,146,918 bp from pter |
Size:
|
4,574 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_025741.14
| Proteins for FABP7
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540 (See
protein sequence)Recommended Name: Fatty acid-binding protein, brain Size: 132 amino acids; 14889 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :1FDQ (3D)
 1FE3 (3D)
 1JJX (3D)
 
Secondary accessions: O14951 Q6IAU7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001437.1
ENSEMBL proteins: ENSP00000357429 ENSP00000348931
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FABP7 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for FABP7: Assays for FABP7: | Protein
Domains/ Families for FABP7(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15540
ProtoNet protein and cluster: O15540 1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein
UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interiorSimilarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | Gene Function for FABP7
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001446
Applied Biosystems Silencer® siRNAs for FABP7
Sigma-Aldrich siRNA for FABP7  Sigma-Aldrich shRNA for FABP7  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001446                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001446                                  untagged cDNA clones in CMV expression vector (see all 2): AL512688 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: AL512688
UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540Function: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity)1 MGI phenotypic allele for Fabp7 (no phenotypes)
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FABP7
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for FABP7 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FABP7 
5/13 Interacting proteins for FABP7 (ENSP000003489313) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FABP7(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FABP7 5 Novoseek chemical compound relationships for FABP7 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fatty acid |
55.37 |
18 |
12479569 (2), 18826602 (2), 18391847 (2), 9591779 (1) (see all 14) |
| docosahexaenoic acid |
47.84 |
12 |
10854433 (3), 8798739 (2), 11103817 (2) |
| lipid |
33.62 |
21 |
12612091 (2), 15622533 (1), 18593473 (1), 18826602 (1) (see all 14) |
| oleic acid |
22.51 |
4 |
8798739 (1), 10854433 (1) |
| arachidonic acid |
3.73 |
3 |
8798739 (1), 10854433 (1) |
About this table
|
Transcripts for FABP7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001446
Sigma-Aldrich siRNA for FABP7  Sigma-Aldrich shRNA for FABP7  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001446 REFSEQ mRNAs for FABP7 gene: NM_001446.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001446               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001446                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001446                                  untagged cDNA clones in CMV expression vector (see all 2): AL512688  Additional cDNA sequence: AB208815.1 AJ002962.1 AK289836.1 AK307272.1 AK311867.1 AL512688.1 BC012299.1 CR457057.1 D50373.1 D88648.1 U51338.1 U81235.1 5 DOTS entries: DT.313655 DT.40110554 DT.91736342 DT.91744417 DT.121347539 24/104 AceView cDNA sequences (see all 104
):AW162191 AI878887 AI879439 AV718267 AW157160 BX113553 BM698823 AI929618 AW163440 AL512688 NM_001446 AI929340 BX461253 D88648 AW163515 BM668866 AJ002962 AW160409 AI652178 BU736791 U81235 AI369673 CR457057 BI544779
highest scoring ESTs for FABP7:AJ002962 AA029795 AA194097 AA340117 AA436624 AA483611 AA513170 AA648648 AA776582 AI131159 Unigene Cluster for FABP7: Fatty acid binding protein 7, brain Hs.26770 [show with all ESTs]Unigene Representative Sequence: AB208815
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000368444
ENST00000356535
|
Expression for FABP7
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FABP7 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FABP7
1 / 2 / 3 7 probe-sets matching FABP7 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTTTATAATT
SOURCE GeneReport for Unigene cluster: Hs.26770
Expression variation in blood from EXPOLDB for FABP7 UniProtKB/Swiss-Prot: FABP7_HUMAN, O15540Tissue specificity: Expressed in brain and other neural tissues |
Orthologs for FABP7
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FABP7 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for FABP7
ENSEMBL Gene Tree for FABP7 | Paralogs for FABP7(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FABP7 gene
- FABP32 FABP5L82
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for FABP7(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FABP7 (up to first 250kb)
|
Disorders & Mutations for FABP7
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602965
6 Novoseek disease relationships for FABP7 gene
About this table
|
Medical News for FABP7(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FABP7 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/75 PubMed articles for FABP7 gene (see all 75
):- Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). (PubMed id 9375786)1, 2, 3, 4 Shimizu F.... Fujiwara T. (1997)
- Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. (PubMed id 10854433)1, 3, 4 Balendiran G.K.... Sacchettini J.C. (2000)
- Correlation of B-FABP and GFAP expression in malignant glioma. (PubMed id 9591779)1, 3, 4 Godbout R.... Day R.S. III (1998)
- Solution structure of fatty acid-binding protein from human brain. (PubMed id 12479569)1, 3, 4 Rademacher M.... Luecke C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Ligand specificity of brain lipid-binding protein. (PubMed id 8798739)1, 3 Xu L.Z....Heintz N. (1996)
- Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. (PubMed id 12612091)1, 3 Miller S.J....Ratner N. (2003)
- Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. (PubMed id 9242429)1, 3 Shi Y.E....Gentz R. (1997)
- B-FABP-expressing radial glial cells: the malignant glioma cell of origin? (PubMed id 17898869)1, 3 Mita R....Godbout R. (2007)
|
Search for FABP7
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FABP7
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FABP7
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FABP7(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FABP7(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FABP7:

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Incremental update: 13 Oct 2009
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