Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FABP7 Gene

Aliases for FABP7 Gene

  • Fatty Acid Binding Protein 7, Brain 2 3
  • FABPB 3 4 6
  • BLBP 3 4 6
  • Mammary-Derived Growth Inhibitor Related 3 4
  • Brain-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 7 3 4
  • Brain Lipid Binding Protein 2 3
  • Brain Lipid-Binding Protein 3 4
  • B-FABP 3 4
  • MRG 3 4
  • Mammary-Derived Growth Inhibitor-Related 3
  • Hypothetical Protein DKFZp547J2313 3
  • Fatty Acid-Binding Protein, Brain 3
  • LTR2-FABP7 3

External Ids for FABP7 Gene

Previous GeneCards Identifiers for FABP7 Gene

  • GC06P122871
  • GC06P123058
  • GC06P123035
  • GC06P123081
  • GC06P123142
  • GC06P120677
  • GC06P123100

Summaries for FABP7 Gene

Entrez Gene Summary for FABP7 Gene

  • The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP7 Gene

FABP7 (Fatty Acid Binding Protein 7, Brain) is a Protein Coding gene. Diseases associated with FABP7 include malignant glioma and subependymal giant cell astrocytoma. Among its related pathways are Neuroscience and PPAR signaling pathway. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot for FABP7 Gene

  • B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).

Gene Wiki entry for FABP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP7 Gene

Genomics for FABP7 Gene

Regulatory Elements for FABP7 Gene

Genomic Location for FABP7 Gene

Start:
122,779,475 bp from pter
End:
122,784,074 bp from pter
Size:
4,600 bases
Orientation:
Plus strand

Genomic View for FABP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP7 Gene

Proteins for FABP7 Gene

  • Protein details for FABP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15540-FABP7_HUMAN
    Recommended name:
    Fatty acid-binding protein, brain
    Protein Accession:
    O15540
    Secondary Accessions:
    • B2R4L1
    • O14951
    • Q6IAU7
    • Q9H047

    Protein attributes for FABP7 Gene

    Size:
    132 amino acids
    Molecular mass:
    14889 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP7 Gene

    Alternative splice isoforms for FABP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FABP7 Gene

Proteomics data for FABP7 Gene at MOPED

Post-translational modifications for FABP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP7 (FABP7)

No data available for DME Specific Peptides for FABP7 Gene

Domains for FABP7 Gene

Gene Families for FABP7 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for FABP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15540

UniProtKB/Swiss-Prot:

FABP7_HUMAN :
  • O15540
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP7: view

Function for FABP7 Gene

Molecular function for FABP7 Gene

UniProtKB/Swiss-Prot Function:
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).

Gene Ontology (GO) - Molecular Function for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP7: view
genes like me logo Genes that share phenotypes with FABP7: view

Animal Model Products

miRNA for FABP7 Gene

miRTarBase miRNAs that target FABP7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FABP7 Gene

Localization for FABP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP7 Gene COMPARTMENTS Subcellular localization image for FABP7 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0042995 cell projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with FABP7: view

Pathways for FABP7 Gene

SuperPathways for FABP7 Gene

genes like me logo Genes that share pathways with FABP7: view

Pathways by source for FABP7 Gene

1 Cell Signaling Technology pathway for FABP7 Gene
1 KEGG pathway for FABP7 Gene

PCR Array Products

Interacting Proteins for FABP7 Gene

Selected Interacting proteins: O15540-FABP7_HUMAN for FABP7 Gene via I2D

Symbol External ID(s) Details
DYNLT1
KBTBD7

Gene Ontology (GO) - Biological Process for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001964 startle response --
GO:0006810 transport IEA --
GO:0007399 nervous system development TAS 9375786
GO:0008285 negative regulation of cell proliferation TAS 9250612
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP7: view

Compounds for FABP7 Gene

(5) Drugbank Compounds for FABP7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Linolenic Acid
  • (9Z,12Z,15Z)-Octadecatrienoic acid
463-40-1 carrier
Docosa-4,7,10,13,16,19-Hexaenoic Acid
carrier
gamma-Homolinolenic acid
  • (Z,Z,Z)-8,11,14-Eicosatrienoic acid
1783-84-2 carrier
Icosapent
  • Eicosapentaenoic acid
10417-94-4 carrier
Oleic Acid
112-80-1 carrier

(8) Novoseek inferred chemical compound relationships for FABP7 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 57.1 21
docosahexaenoic acid 44.8 7
lipid 30.4 15
oleic acid 19.5 2
retinoic acid 15.9 1
genes like me logo Genes that share compounds with FABP7: view

Transcripts for FABP7 Gene

mRNA/cDNA for FABP7 Gene

Unigene Clusters for FABP7 Gene

Fatty acid binding protein 7, brain:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP7 Gene

No ASD Table

Relevant External Links for FABP7 Gene

GeneLoc Exon Structure for
FABP7
ECgene alternative splicing isoforms for
FABP7

Expression for FABP7 Gene

mRNA expression in normal human tissues for FABP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.8), Brain - Cerebellum (7.2), Brain - Amygdala (5.9), Brain - Hippocampus (4.7), and Brain - Anterior cingulate cortex (BA24) (4.6).

Protein differential expression in normal tissues for FABP7 Gene

This gene is overexpressed in Fetal Brain (28.1), Retina (23.0), and Brain (8.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FABP7 Gene

SOURCE GeneReport for Unigene cluster for FABP7 Gene Hs.26770

mRNA Expression by UniProt/SwissProt for FABP7 Gene

O15540-FABP7_HUMAN
Tissue specificity: Expressed in brain and other neural tissues
genes like me logo Genes that share expressions with FABP7: view

In Situ Assay Products

No data available for Expression partners for FABP7 Gene

Orthologs for FABP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FABP7 35
  • 92.17 (n)
  • 95.45 (a)
FABP7 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP7 35
  • 92.68 (n)
  • 94.7 (a)
FABP7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp7 35
  • 85.35 (n)
  • 87.12 (a)
Fabp7 16
Fabp7 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FABP7 35
  • 99.75 (n)
  • 99.24 (a)
FABP7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp7 35
  • 86.62 (n)
  • 88.64 (a)
oppossum
(Monodelphis domestica)
Mammalia FABP7 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FABP7 35
  • 81.31 (n)
  • 91.67 (a)
FABP7 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP7 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp7 35
  • 81.57 (n)
  • 86.36 (a)
Str.17054 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15814 35
zebrafish
(Danio rerio)
Actinopterygii fabp7 35
fabp7b 35
  • 73.23 (n)
  • 78.79 (a)
fabp7a 36
  • 83 (a)
OneToMany
fabp7b 36
  • 79 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12474 35
African malaria mosquito
(Anopheles gambiae)
Insecta FABP_ANOGA_a 35
  • 54.55 (n)
  • 50.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta fabp 35
  • 54.82 (n)
  • 54.55 (a)
fabp 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 36
  • 40 (a)
ManyToMany
lbp-6 36
  • 47 (a)
ManyToMany
lbp-7 36
  • 37 (a)
ManyToMany
lbp-8 36
  • 31 (a)
ManyToMany
lbp-9 36
  • 36 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2819 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for FABP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP7 Gene

ENSEMBL:
Gene Tree for FABP7 (if available)
TreeFam:
Gene Tree for FABP7 (if available)

Paralogs for FABP7 Gene

Paralogs for FABP7 Gene

Selected SIMAP similar genes for FABP7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FABP7 Gene

genes like me logo Genes that share paralogs with FABP7: view

Variants for FABP7 Gene

Sequence variations from dbSNP and Humsavar for FABP7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11184 -- 122,784,000(+) TTTTT(A/T)ATAAA utr-variant-3-prime
rs1564899 -- 122,782,941(-) TCTGG(A/G)AAAAA intron-variant, downstream-variant-500B
rs1564900 -- 122,782,753(-) GCTGA(C/T)TGCAG intron-variant, utr-variant-3-prime
rs2171067 -- 122,780,969(-) TCCTA(G/T)TGTTA intron-variant
rs2171068 -- 122,780,203(-) ATCCA(C/G)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FABP7 Gene

Variant ID Type Subtype PubMed ID
nsv830791 CNV Gain 17160897
nsv886601 CNV Gain 21882294

Relevant External Links for FABP7 Gene

HapMap Linkage Disequilibrium report
FABP7
Human Gene Mutation Database (HGMD)
FABP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP7 Gene

Disorders for FABP7 Gene

(6) Novoseek inferred disease relationships for FABP7 Gene

Disease -log(P) Hits PubMed IDs
malignant glioma 45.2 17
carcinoma renal cell 18 5
tumors 16.4 15
breast cancer 8.7 8
breast carcinoma 5.16 2

Relevant External Links for FABP7

Genetic Association Database (GAD)
FABP7
Human Genome Epidemiology (HuGE) Navigator
FABP7
genes like me logo Genes that share disorders with FABP7: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for FABP7 Gene

Publications for FABP7 Gene

  1. Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). (PMID: 9375786) Shimizu F. … Fujiwara T. (Biochim. Biophys. Acta 1997) 2 3 4 23
  2. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. (PMID: 10854433) Balendiran G.K. … Sacchettini J.C. (J. Biol. Chem. 2000) 3 4 23 25
  3. Correlation of B-FABP and GFAP expression in malignant glioma. (PMID: 9591779) Godbout R. … Day R.S. III (Oncogene 1998) 3 4 23
  4. Solution structure of fatty acid-binding protein from human brain. (PMID: 12479569) Rademacher M. … Luecke C. (Mol. Cell. Biochem. 2002) 3 4 23
  5. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (PMID: 19554614) Iwayama Y. … Yoshikawa T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48

Products for FABP7 Gene

Sources for FABP7 Gene

Back to Top

Content