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Aliases for FABP7 Gene

Aliases for FABP7 Gene

  • Fatty Acid Binding Protein 7 2 3 5
  • Brain-Type Fatty Acid-Binding Protein 3 4
  • Brain Lipid-Binding Protein 3 4
  • B-FABP 3 4
  • FABPB 3 4
  • BLBP 3 4
  • MRG 3 4
  • Mammary-Derived Growth Inhibitor-Related 3
  • Mammary-Derived Growth Inhibitor Related 4
  • Fatty Acid Binding Protein 7, Brain 2
  • Hypothetical Protein DKFZp547J2313 3
  • Fatty Acid-Binding Protein, Brain 3
  • Fatty Acid-Binding Protein 7 4
  • Brain Lipid Binding Protein 2

External Ids for FABP7 Gene

Previous GeneCards Identifiers for FABP7 Gene

  • GC06P122871
  • GC06P123058
  • GC06P123035
  • GC06P123081
  • GC06P123142
  • GC06P120677
  • GC06P123100

Summaries for FABP7 Gene

Entrez Gene Summary for FABP7 Gene

  • The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]

GeneCards Summary for FABP7 Gene

FABP7 (Fatty Acid Binding Protein 7) is a Protein Coding gene. Diseases associated with FABP7 include Optic Nerve Glioma and Subependymal Giant Cell Astrocytoma. Among its related pathways are Metabolism and Neuroscience. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot for FABP7 Gene

  • B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).

Gene Wiki entry for FABP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP7 Gene

Genomics for FABP7 Gene

Regulatory Elements for FABP7 Gene

Enhancers for FABP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F122780 0.5 Ensembl 36.5 +0.8 826 0.2 FABP7 SMPDL3A
GH06F122753 1.1 FANTOM5 Ensembl ENCODE 15.7 -25.5 -25475 1.2 ZNF366 IRF1 YY1 SMPDL3A FABP7 RN7SL564P
GH06F122832 0.7 FANTOM5 ENCODE 12.7 +53.7 53706 0.8 OSR2 SMARCA4 POLR2A ZEB2 ZNF843 WT1 ATF2 ZNF18 FABP7 SMPDL3A PKIB SERINC1 CLVS2 GC06M122860
GH06F122751 0.6 Ensembl 11.8 -27.8 -27775 1.0 IKZF1 SMPDL3A FABP7 RN7SL564P
GH06F122752 0.4 Ensembl 11.6 -26.5 -26475 0.4 SMPDL3A FABP7 RN7SL564P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FABP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for FABP7 Gene

Chromosome:
6
Start:
122,779,475 bp from pter
End:
122,784,074 bp from pter
Size:
4,600 bases
Orientation:
Plus strand

Genomic View for FABP7 Gene

Genes around FABP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP7 Gene

Proteins for FABP7 Gene

  • Protein details for FABP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15540-FABP7_HUMAN
    Recommended name:
    Fatty acid-binding protein, brain
    Protein Accession:
    O15540
    Secondary Accessions:
    • B2R4L1
    • O14951
    • Q6IAU7
    • Q9H047

    Protein attributes for FABP7 Gene

    Size:
    132 amino acids
    Molecular mass:
    14889 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP7 Gene

    Alternative splice isoforms for FABP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FABP7 Gene

Post-translational modifications for FABP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP7 (FABP7)
  • Cloud-Clone Corp. Antibodies for FABP7
  • Santa Cruz Biotechnology (SCBT) Antibodies for FABP7

No data available for DME Specific Peptides for FABP7 Gene

Domains & Families for FABP7 Gene

Gene Families for FABP7 Gene

Suggested Antigen Peptide Sequences for FABP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15540

UniProtKB/Swiss-Prot:

FABP7_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP7: view

Function for FABP7 Gene

Molecular function for FABP7 Gene

UniProtKB/Swiss-Prot Function:
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).

Gene Ontology (GO) - Molecular Function for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP7: view
genes like me logo Genes that share phenotypes with FABP7: view

Animal Models for FABP7 Gene

MGI Knock Outs for FABP7:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP7 Gene

Localization for FABP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP7 Gene COMPARTMENTS Subcellular localization image for FABP7 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with FABP7: view

Pathways & Interactions for FABP7 Gene

genes like me logo Genes that share pathways with FABP7: view

Pathways by source for FABP7 Gene

Interacting Proteins for FABP7 Gene

SIGNOR curated interactions for FABP7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007399 nervous system development TAS 9375786
GO:0008285 negative regulation of cell proliferation TAS 9250612
GO:0019433 triglyceride catabolic process TAS --
GO:0021846 cell proliferation in forebrain IEA --
genes like me logo Genes that share ontologies with FABP7: view

Drugs & Compounds for FABP7 Gene

(7) Drugs for FABP7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist, Carrier 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist, Carrier 0
Gamma-Homolinolenic acid Approved Nutra Carrier 0
Icosapent Approved Nutra Carrier Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0
Docosa-4,7,10,13,16,19-Hexaenoic Acid Experimental Pharma Carrier 0

(5) Additional Compounds for FABP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FABP7: view

Transcripts for FABP7 Gene

Unigene Clusters for FABP7 Gene

Fatty acid binding protein 7, brain:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP7 Gene

No ASD Table

Relevant External Links for FABP7 Gene

GeneLoc Exon Structure for
FABP7
ECgene alternative splicing isoforms for
FABP7

Expression for FABP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FABP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.8), Brain - Cerebellum (x7.2), Brain - Amygdala (x5.9), Brain - Hippocampus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for FABP7 Gene

This gene is overexpressed in Fetal Brain (28.1), Retina (23.0), and Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FABP7 Gene



NURSA nuclear receptor signaling pathways regulating expression of FABP7 Gene:

FABP7

SOURCE GeneReport for Unigene cluster for FABP7 Gene:

Hs.26770

mRNA Expression by UniProt/SwissProt for FABP7 Gene:

O15540-FABP7_HUMAN
Tissue specificity: Expressed in brain and other neural tissues.
genes like me logo Genes that share expression patterns with FABP7: view

Primer Products

No data available for Protein tissue co-expression partners for FABP7 Gene

Orthologs for FABP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP7 34 35
  • 99.75 (n)
oppossum
(Monodelphis domestica)
Mammalia FABP7 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP7 34 35
  • 92.68 (n)
cow
(Bos Taurus)
Mammalia FABP7 34 35
  • 92.17 (n)
rat
(Rattus norvegicus)
Mammalia Fabp7 34
  • 86.62 (n)
mouse
(Mus musculus)
Mammalia Fabp7 34 16 35
  • 85.35 (n)
chicken
(Gallus gallus)
Aves FABP7 34 35
  • 81.31 (n)
lizard
(Anolis carolinensis)
Reptilia FABP7 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp7 34
  • 81.57 (n)
Str.17054 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15814 34
zebrafish
(Danio rerio)
Actinopterygii fabp7a 35
  • 83 (a)
OneToMany
fabp7b 34 35
  • 73.23 (n)
fabp7 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12474 34
fruit fly
(Drosophila melanogaster)
Insecta fabp 34 35
  • 54.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta FABP_ANOGA_a 34
  • 54.55 (n)
worm
(Caenorhabditis elegans)
Secernentea lbp-6 35
  • 47 (a)
ManyToMany
lbp-5 35
  • 40 (a)
ManyToMany
lbp-7 35
  • 37 (a)
ManyToMany
lbp-9 35
  • 36 (a)
ManyToMany
lbp-8 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2819 34
Species where no ortholog for FABP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP7 Gene

ENSEMBL:
Gene Tree for FABP7 (if available)
TreeFam:
Gene Tree for FABP7 (if available)

Paralogs for FABP7 Gene

Paralogs for FABP7 Gene

(15) SIMAP similar genes for FABP7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FABP7 Gene

genes like me logo Genes that share paralogs with FABP7: view

Variants for FABP7 Gene

Sequence variations from dbSNP and Humsavar for FABP7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs431905492 untested 122,780,456(+) TAGAA(-/A)CTGTA reference, frameshift-variant
rs10593753 -- 122,774,390(+) AAGAC(-/AGAG)AGAGA intron-variant
rs10872249 -- 122,748,292(+) ccaca(C/T)gcaca upstream-variant-2KB
rs10872251 -- 122,782,949(+) AGAAC(A/G)CAGAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs111226217 -- 122,757,382(+) TCACC(A/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FABP7 Gene

Variant ID Type Subtype PubMed ID
nsv1035007 CNV gain 25217958
nsv830791 CNV gain 17160897

Variation tolerance for FABP7 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP7 Gene

Human Gene Mutation Database (HGMD)
FABP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP7 Gene

Disorders for FABP7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FABP7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
optic nerve glioma
  • glioma of the optic nerve
subependymal giant cell astrocytoma
  • sega
optic nerve neoplasm
  • neoplasm of optic nerve
- elite association - COSMIC cancer census association via MalaCards
Search FABP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP7

Genetic Association Database (GAD)
FABP7
Human Genome Epidemiology (HuGE) Navigator
FABP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP7
genes like me logo Genes that share disorders with FABP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP7 Gene

Publications for FABP7 Gene

  1. Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). (PMID: 9375786) Shimizu F. … Fujiwara T. (Biochim. Biophys. Acta 1997) 2 3 4 22 64
  2. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (PMID: 19554614) Iwayama Y. … Yoshikawa T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  3. Solution structure of fatty acid-binding protein from human brain. (PMID: 12479569) Rademacher M. … Luecke C. (Mol. Cell. Biochem. 2002) 3 4 22 64
  4. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. (PMID: 10854433) Balendiran G.K. … Sacchettini J.C. (J. Biol. Chem. 2000) 3 4 22 64
  5. Correlation of B-FABP and GFAP expression in malignant glioma. (PMID: 9591779) Godbout R. … Day R.S. III (Oncogene 1998) 3 4 22 64

Products for FABP7 Gene

Sources for FABP7 Gene

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