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Aliases for FABP6 Gene

Aliases for FABP6 Gene

  • Fatty Acid Binding Protein 6, Ileal 2 3
  • Ileal Bile Acid Binding Protein 2 3
  • Illeal Lipid-Binding Protein 2 3
  • Ileal Lipid-Binding Protein 3 4
  • Intestinal 15 KDa Protein 3 4
  • I-BABP 3 4
  • I-15P 3 4
  • ILLBP 3 4
  • ILBP 3 4
  • GT 3 4
  • Intestinal Bile Acid-Binding Protein 4
  • Fatty Acid-Binding Protein 6 4
  • Gastrotropin 2
  • I-BALB 3
  • I-BAP 3
  • ILBP3 3

External Ids for FABP6 Gene

Previous GeneCards Identifiers for FABP6 Gene

  • GC05P159759
  • GC05P159549
  • GC05P159621
  • GC05P159573
  • GC05P154708

Summaries for FABP6 Gene

Entrez Gene Summary for FABP6 Gene

  • This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP6 Gene

FABP6 (Fatty Acid Binding Protein 6, Ileal) is a Protein Coding gene. Diseases associated with FABP6 include colorectal adenocarcinoma and glanzmann thrombasthenia. Among its related pathways are Metabolism and PPAR signaling pathway. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is FABP1.

UniProtKB/Swiss-Prot for FABP6 Gene

  • Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Gene Wiki entry for FABP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP6 Gene

Genomics for FABP6 Gene

Regulatory Elements for FABP6 Gene

Genomic Location for FABP6 Gene

Chromosome:
5
Start:
160,187,367 bp from pter
End:
160,238,735 bp from pter
Size:
51,369 bases
Orientation:
Plus strand

Genomic View for FABP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP6 Gene

Proteins for FABP6 Gene

  • Protein details for FABP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51161-FABP6_HUMAN
    Recommended name:
    Gastrotropin
    Protein Accession:
    P51161
    Secondary Accessions:
    • Q07DR7
    • Q8TBI3
    • Q9UGI7

    Protein attributes for FABP6 Gene

    Size:
    128 amino acids
    Molecular mass:
    14371 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FABP6 Gene

    Alternative splice isoforms for FABP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FABP6 Gene

Proteomics data for FABP6 Gene at MOPED

Post-translational modifications for FABP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP6 Gene

Antibody Products

No data available for DME Specific Peptides for FABP6 Gene

Domains & Families for FABP6 Gene

Gene Families for FABP6 Gene

Protein Domains for FABP6 Gene

Suggested Antigen Peptide Sequences for FABP6 Gene

Graphical View of Domain Structure for InterPro Entry

P51161

UniProtKB/Swiss-Prot:

FABP6_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP6: view

Function for FABP6 Gene

Molecular function for FABP6 Gene

GENATLAS Biochemistry:
fatty acid binding protein 6,gastrotropin,expressed in the ileum
UniProtKB/Swiss-Prot Function:
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
UniProtKB/Swiss-Prot Induction:
Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2 is up-regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in all stages of colorectal adenocarcinoma.

Gene Ontology (GO) - Molecular Function for FABP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008289 lipid binding TAS 7588781
GO:0032052 bile acid binding IEA --
genes like me logo Genes that share ontologies with FABP6: view
genes like me logo Genes that share phenotypes with FABP6: view

Animal Models for FABP6 Gene

MGI Knock Outs for FABP6:

Animal Model Products

CRISPR Products

miRNA for FABP6 Gene

miRTarBase miRNAs that target FABP6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FABP6 Gene

Localization for FABP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP6 Gene

Isoform 1: Cytoplasm.
Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP6 Gene COMPARTMENTS Subcellular localization image for FABP6 gene
Compartment Confidence
cytosol 4
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FABP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 7588781
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP6: view

Pathways & Interactions for FABP6 Gene

genes like me logo Genes that share pathways with FABP6: view

PCR Array Products

Interacting Proteins for FABP6 Gene

Gene Ontology (GO) - Biological Process for FABP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 9250612
GO:0006810 transport --
GO:0008206 bile acid metabolic process TAS --
GO:0008285 negative regulation of cell proliferation TAS 9250612
GO:0015721 bile acid and bile salt transport TAS --
genes like me logo Genes that share ontologies with FABP6: view

No data available for SIGNOR curated interactions for FABP6 Gene

Drugs & Compounds for FABP6 Gene

(11) Drugs for FABP6 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
chenodeoxycholic acid Approved Pharma Antagonist 23
deoxycholic acid Approved Pharma Antagonist 40
Ursodeoxycholic acid Approved, Investigational Pharma 74
cholestyramine Approved Pharma 0

(86) Additional Compounds for FABP6 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6
genes like me logo Genes that share compounds with FABP6: view

Transcripts for FABP6 Gene

Unigene Clusters for FABP6 Gene

Fatty acid binding protein 6, ileal:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -
SP3:

Relevant External Links for FABP6 Gene

GeneLoc Exon Structure for
FABP6
ECgene alternative splicing isoforms for
FABP6

Expression for FABP6 Gene

mRNA expression in normal human tissues for FABP6 Gene

mRNA differential expression in normal tissues according to GTEx for FABP6 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x41.6).

Protein differential expression in normal tissues from HIPED for FABP6 Gene

This gene is overexpressed in Adrenal (28.3), Rectum (21.8), and Skin (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FABP6 Gene



SOURCE GeneReport for Unigene cluster for FABP6 Gene Hs.519719

mRNA Expression by UniProt/SwissProt for FABP6 Gene

P51161-FABP6_HUMAN
Tissue specificity: Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
genes like me logo Genes that share expression patterns with FABP6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FABP6 Gene

Orthologs for FABP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FABP6 35
  • 82.03 (n)
  • 70.31 (a)
FABP6 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP6 35
  • 85.94 (n)
  • 78.12 (a)
FABP6 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp6 35
  • 81.51 (n)
  • 79.69 (a)
Fabp6 16
Fabp6 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FABP6 35
  • 99.25 (n)
  • 98.87 (a)
FABP6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp6 35
  • 80.99 (n)
  • 78.12 (a)
oppossum
(Monodelphis domestica)
Mammalia FABP6 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FABP6 35
  • 65.89 (n)
  • 63.28 (a)
FABP6 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP6 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487630 35
  • 63.52 (n)
  • 62.2 (a)
zebrafish
(Danio rerio)
Actinopterygii fabp6 35
  • 66.67 (n)
  • 59.32 (a)
fabp6 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4471 36
  • 32 (a)
OneToMany
Species with no ortholog for FABP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FABP6 Gene

ENSEMBL:
Gene Tree for FABP6 (if available)
TreeFam:
Gene Tree for FABP6 (if available)

Paralogs for FABP6 Gene

Paralogs for FABP6 Gene

(2) SIMAP similar genes for FABP6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FABP6: view

Variants for FABP6 Gene

Sequence variations from dbSNP and Humsavar for FABP6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_039578 -
VAR_039579 -
VAR_039580 -

Structural Variations from Database of Genomic Variants (DGV) for FABP6 Gene

Variant ID Type Subtype PubMed ID
dgv359n21 CNV Loss 19592680

Variation tolerance for FABP6 Gene

Residual Variation Intolerance Score: 79.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.92; 95.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP6 Gene

HapMap Linkage Disequilibrium report
FABP6
Human Gene Mutation Database (HGMD)
FABP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP6 Gene

Disorders for FABP6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FABP6 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
glanzmann thrombasthenia
  • glanzmann's thrombasthenia
bleeding disorder, platelet-type, 16, autosomal dominant
  • bleeding disorder, platelet-type 16
myocardial infarction
  • myocardial infarction, protection against
- elite association
Search FABP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP6

Genetic Association Database (GAD)
FABP6
Human Genome Epidemiology (HuGE) Navigator
FABP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP6
genes like me logo Genes that share disorders with FABP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP6 Gene

Publications for FABP6 Gene

  1. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M. … Kramer W. (Proteins 2003) 23 26 67
  2. Cloning and chromosomal localization of the human ileal lipid-binding protein. (PMID: 7619861) Oelkers P. … Dawson P.A. (Biochim. Biophys. Acta 1995) 2 23 67
  3. Chicken ileal bile-acid-binding protein: a promising target of investigation to understand binding co-operativity across the protein family. (PMID: 19874274) Guariento M. … Molinari H. (Biochem. J. 2010) 23 67
  4. Loss of enterocyte mass is accompanied by diminished turnover of enterocytes after myeloablative therapy in haematopoietic stem-cell transplant recipients. (PMID: 18725393) Derikx J.P. … Buurman W.A. (Ann. Oncol. 2009) 23 67
  5. Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma. (PMID: 19174784) Dvorak K. … Bernstein H. (Am. J. Gastroenterol. 2009) 23 67

Products for FABP6 Gene

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