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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FABP6 Gene

protein-coding   GIFtS: 65
GCID: GC05P159573

Fatty Acid Binding Protein 6, Ileal

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fatty Acid Binding Protein 6, Ileal1 2     I-15P2 3
ILLBP2 3 5     I-BABP2 3
gastrotropin1 2     ILBP2 3
Ileal Bile Acid Binding Protein1 2     I-BALB2
Illeal Lipid-Binding Protein1 2     I-BAP2
Ileal Lipid-Binding Protein2 3     ILBP32
Intestinal 15 KDa Protein2 3     Fatty Acid-Binding Protein 63
GT2 3     Intestinal Bile Acid-Binding Protein3

External Ids:    HGNC: 35611   Entrez Gene: 21722   Ensembl: ENSG000001702317   OMIM: 6004225   UniProtKB: P511613   

Export aliases for FABP6 gene to outside databases

Previous GC identifers: GC05P159759 GC05P160150 GC05P159549 GC05P159621 GC05P154708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FABP6 Gene:
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly
conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1
(the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include
fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters
and/or alternate splicing have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FABP6 Gene: 
FABP6 (fatty acid binding protein 6, ileal) is a protein-coding gene. Diseases associated with FABP6 include plantar fasciitis, and fasciitis, and among its related super-pathways are Synthesis of bile acids and bile salts and Metabolic pathways. GO annotations related to this gene include lipid binding and transporter activity. An important paralog of this gene is FABP1.

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile
salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced
apoptosis

Gene Wiki entry for FABP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FABP6 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FABP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FABP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3-q34   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q23-q35

FABP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159573:  view genomic region     (about GC identifiers)

Start:
159,614,374 bp from pter      End:
159,665,742 bp from pter
Size:
51,369 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161 (See protein sequence)
Recommended Name: Gastrotropin  
Size: 128 amino acids; 14371 Da
Subcellular location: Isoform 1: Cytoplasm
Subcellular location: Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and
neoplastic cells
Sequence caution: Sequence=AAH22489.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for FABP6:
1O1U (3D)        1O1V (3D)    
Secondary accessions: Q07DR7 Q8TBI3 Q9UGI7
Alternative promoter usage: 2 isoforms:  P51161-1   P51161-2   

Explore the universe of human proteins at neXtProt for FABP6: NX_P51161

Explore proteomics data for FABP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51161

  • FABP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FABP6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001035532.1  NP_001124430.1  NP_001436.1  

    ENSEMBL proteins: 
     ENSP00000377549   ENSP00000428766   ENSP00000385433   ENSP00000377551  
    Reactome Protein details: P51161
    Human Recombinant Protein Products for FABP6: 
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    Cloud-Clone Corp. Proteins for FABP6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm TAS7588781
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--

    FABP6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FABP: Fatty acid binding protein family

    3 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd

    Graphical View of Domain Structure for InterPro Entry P51161

    ProtoNet protein and cluster: P51161

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    FABP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FABP6_HUMAN, P51161
    Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile
    salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced
    apoptosis
    Induction: Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2
    is up-regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in
    all stages of colorectal adenocarcinoma

         Genatlas biochemistry entry for FABP6:
    fatty acid binding protein 6,gastrotropin,expressed in the ileum

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0008289lipid binding IEA--
         
    FABP6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fabp6):
     homeostasis/metabolism  liver/biliary system 

    FABP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fabp6tm1Lbal for FABP6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FABP6 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FABP6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.74
    Recycling of bile acids and salts0.35
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3PPAR signaling pathway
    PPAR signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for FABP6
        Bile acid and bile salt metabolism
    Metabolism
    Recycling of bile acids and salts
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for FABP6):
        PPAR signaling pathway


    FABP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FABP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for FABP6 (P511613 ENSP000003775494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS2P051623I2D: score=1 
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ALBENSP000002958974STRING: ENSP00000295897
    SLC10A1ENSP000002165404STRING: ENSP00000216540
    SLC10A2ENSP000002453124STRING: ENSP00000245312
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process NAS9250612
    GO:0008206bile acid metabolic process TAS--
    GO:0008285negative regulation of cell proliferation TAS9250612
    GO:0015721bile acid and bile salt transport TAS--
    GO:0044281small molecule metabolic process TAS--

    FABP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FABP6 for compounds           About GeneDecksing

    EMD Millipore small molecules for FABP6:
    Small Molecule - inhibitor
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    10/85 HMDB Compounds for FABP6 (see all 85)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-412486725
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-112486725
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-712486725
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-012486725
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-112486725
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-612486725
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-812486725
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-612486725
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-112486725
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-812486725

    3 DrugBank Compounds for FABP6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Cholylglycine-- 475-31-0target--17139284 17016423 10592235
    Taurocholic Acid-- 81-24-3target--17139284 17016423
    Cholic Acid-- 81-25-4target--10592235

    10/13 Novoseek inferred chemical compound relationships for FABP6 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gw 4064 77.8 2 15309887 (1), 17047076 (1)
    glycocholate 74.3 6 16411748 (3), 16230354 (1), 14529265 (1)
    chenodeoxycholic acid 72.3 4 15309887 (1), 16230354 (1), 11254888 (1), 14529265 (1)
    deoxycholic acid 64.7 1 14529265 (1)
    taurocholate 54.8 3 12486725 (1), 10514450 (1)
    cholesterol 50.8 18 11684682 (5), 14770367 (3), 12479580 (2), 10334992 (1) (see all 6)
    cholestyramine 48.5 2 10514450 (1), 9461519 (1)
    fatty acid 44.2 20 12479567 (2), 19744871 (2), 16951225 (2), 12486725 (1) (see all 9)
    palmitate 36.4 2 7588781 (1), 9461519 (1)
    sterol 33.8 5 12479580 (1), 11684682 (1), 14770367 (1)

    Search CenterWatch for drugs/clinical trials and news about FABP6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FABP6 gene (3 alternative transcripts): 
    NM_001040442.1  NM_001130958.1  NM_001445.2  

    Unigene Cluster for FABP6:

    Fatty acid binding protein 6, ileal
    Hs.519719  [show with all ESTs]
    Unigene Representative Sequence: BG192623
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393980(uc003lxx.1) ENST00000523955 ENST00000402432(uc003lya.1)
    ENST00000521362 ENST00000393982(uc003lxz.1)
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    Additional mRNA sequence: 

    BC022489.1 DQ132786.1 U19869.1 X90908.1 

    4 DOTS entries:

    DT.75184141  DT.308000  DT.95090225  DT.91740229 

    24/34 AceView cDNA sequences (see all 34):

    AI311734 BM974219 AA953208 BU683560 NM_001445 AI744217 U19869 BQ066098 
    AI301666 AA960993 BX098894 AA873080 BV203713 BC022489 BG192623 BQ188379 
    AI208231 BG208058 AI765588 BU502298 AI799578 AA885617 AI310410 AI689696 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FABP6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:              -     -                           
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for FABP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FABP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAGCCGG
    FABP6 Expression
    About this image


    See FABP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FABP6

    SOURCE GeneReport for Unigene cluster: Hs.519719

    UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
    Tissue specificity: Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at
    protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is
    expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon,
    sigmoid colon and rectum

        SABiosciences Expression via Pathway-Focused PCR Arrays including FABP6: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FABP6 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fabp61 , 5 fatty acid binding protein 6, ileal (gastrotropin)1, 5 81.51(n)1
    79.69(a)1
      11 (25.81 cM)5
    162041  NM_008375.11  NP_032401.11 
     435960495 
    chicken
    (Gallus gallus)
    Aves FABP61 fatty acid binding protein 6, ileal 65.36(n)
    62.5(a)
      416154  XM_003642049.1  XP_003642097.1 
    lizard
    (Anolis carolinensis)
    Reptilia FABP66
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343286.1(1149029-1158363)
    zebrafish
    (Danio rerio)
    Actinopterygii fabp61 fatty acid binding protein 6, ileal (gastrotropin) 66.95(n)
    59.83(a)
      415166  NM_001002076.1  NP_001002076.1 


    ENSEMBL Gene Tree for FABP6 (if available)
    TreeFam Gene Tree for FABP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FABP6 gene
    FABP12  
    2 SIMAP similar genes for FABP6 using alignment to 2 protein entries:     FABP6_HUMAN (see all proteins):
    FABP1    FABP2

    FABP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1370 SNPs in FABP6 are shown (see all 1370)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs773488521,2
    C--154733022(+) AAGTT-/C/CTT 
            
    TTTTT
    4 -- int1 cds10--------
    rs113144911,2
    C--154748201(+) AAGCCT/-AAAAG 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs106264161,2
    C--159615072(+) ATTTT-/AT/TA 
            
    TTATT
    1 -- int11CSA 2
    rs343182341,2
    C--159615073(+) TTTTT-/AT/TA 
            
    TATTT
    1 -- int11NA 2
    rs582619911,2
    C--159618097(+) AAAAA-/A/AA  
            
    GCAAA
    1 -- int10--------
    rs342760611,2
    C--159618823(+) AAAAA-/AA    
       
    /AAAA
    AAAAA
    1 -- int11NA 2
    rs30445421,2
    C--159619341(+) GTCTT-/CT    
       T
    /TCT
    ATCCC
    2 -- cds11NA 2
    rs562758411,2
    C--159620918(+) CTTGG-/GCGGTC 1 -- int10--------
    rs119547221,2
    C,A,H--159620966(+) tcgtcC/Ggggag 1 -- int10--------
    rs119547831,2
    C,H--159621163(+) tcattC/Gcccgg 1 -- int10--------

    HapMap Linkage Disequilibrium report for FABP6 (159614374 - 159665742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FABP6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv359n21CNV Loss19592680


    Human Gene Mutation Database (HGMD): FABP6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FABP6
    DNA2.0 Custom Variant and Variant Library Synthesis for FABP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600422    OMIM disorders: --

    12 diseases for FABP6:    About MalaCards
    plantar fasciitis    fasciitis    intrahepatic cholestasis    barrett's esophagus
    cholestasis    esophageal adenocarcinoma    colorectal cancer    colon cancer
    obesity    esophagitis    adenocarcinoma    breast cancer


    FABP6 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FABP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 20.1 4 12479567 (1), 16385255 (1)
    colorectal cancer 5.64 5 17909007 (2), 16951225 (1)

    Genetic Association Database (GAD): FABP6
    Human Genome Epidemiology (HuGE) Navigator: FABP6 (5 documents)

    Export disorders for FABP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FABP6 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with FABP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the human ileal lipid-binding protein. (PubMed id 7619861)1, 2, 3, 9 Oelkers P. and Dawson P.A. (1995)
    2. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)1, 2, 6, 9 Kurz M....Kramer W. (2003)
    3. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. (PubMed id 7588781)1, 2, 9 Fujita M.... Ono T. (1995)
    4. A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. (PubMed id 17909007)1, 2, 9 Fang C.... Smith J.W. (2007)
    5. Evidence for the Thr79Met polymorphism of the ileal f atty acid binding protein (FABP6) to be associated with type 2 diabetes in obes e individuals. (PubMed id 19744871)1, 4, 9 Fisher E....DAPring F. (2009)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PubMed id 17266179)1, 4 Fisher E....Doring F. (2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. (PubMed id 7894165)1, 3 Birkenmeier E.H....Gordon J.I. (1994)
    10. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. (PubMed id 15936983)1, 9 Landrier J.F....Besnard P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2172 HGNC: 3561 AceView: FABP6 Ensembl:ENSG00000170231 euGenes: HUgn2172
    ECgene: FABP6 Kegg: 2172 H-InvDB: FABP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FABP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FABP6 gene:
    Search GeneIP for patents involving FABP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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