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FABP6 Gene

protein-coding   GIFtS: 60

GC05P159573
fatty acid binding protein 6, ileal
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for FABP6

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
GT 3
I-15P 1, 2, 3
I-BABP 1, 2, 3
I-BALB 1, 2
I-BAP 1, 2
ILBP 1, 2, 3
ILBP3 1, 2
ILLBP 1, 2, 3, 5
OTTHUMP00000160846 2
gastrotropin 2
Descriptions
Fatty acid-binding protein 6 3
Ileal lipid-binding protein 3
Intestinal 15 kDa protein 3
Intestinal bile acid-binding protein 3
fatty acid binding protein 6, ileal 2
ileal bile acid binding protein 2
illeal lipid-binding protein 2
External Ids
HGNC: 35611
Entrez Gene: 21722
UniProtKB: P511613
Ensembl: ENSG000001702317
Search outside databases for aliases for FABP6 gene

Previous GC identifers: GC05P159759 GC05P160150 GC05P159549 GC05P159621

Summaries
for FABP6

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for FABP6:
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of
small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other
hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind
bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
Transcript variants generated by alternate transcription promoters and/or alternate splicing have
been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to
bind to bile salts and bilirubins

Gene Wiki entry for FABP6

Genomic Location
for FABP6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FABP6 gene  

Entrez Gene cytogenetic band: 5q33.3-q34   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q23-q35

FABP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159573:     (about GC identifiers)

Start:
 159,546,952 bp from pter
End:
 159,598,320 bp from pter
Size:
 51,369 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000005.8  NT_023133.12  

Proteins
for FABP6

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161 (See protein sequence)
Recommended Name: Gastrotropin  
Size: 128 amino acids; 14371 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1O1U (3D)    1O1V (3D)    
Secondary accessions: Q8TBI3 Q9UGI7

REFSEQ proteins (3 alternative transcripts): 
NP_001035532.1  NP_001124430.1  NP_001436.1  


ENSEMBL proteins: 
ENSP00000385433 ENSP00000312283 ENSP00000377549 ENSP00000377551 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (FABP6)
Human Recombinant Proteins from Abnova (FABP6)
              OriGene Purified Recombinant Human Protein: FABP6 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm TAS7588781
GO:0005829 cytosol IEA--
About this table

Antibodies for FABP6: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for FABP6
R&D Systems Antibodies for FABP6
Antibodies from Abcam (FABP6), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (FABP6)
Novus Biologicals Antibodies for FABP6

Assays for FABP6: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for FABP6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro domains/families:
 IPR000463 Fatty_acid_bd
 IPR000566 Lipocln_cytFABP


   GeneDecks  FABP6 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P51161

ProtoNet protein and cluster: P51161

1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

Gene Function
for FABP6

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (FABP6)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FABP6)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001445

              Applied Biosystems Silencer® siRNAs for FABP6

              Sigma-Aldrich siRNA for FABP6  
                     Sigma-Aldrich shRNA for FABP6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040442
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040442
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001040442 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001040442

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to
bind to bile salts and bilirubins

Genatlas biochemistry entry for FABP6:
fatty acid binding protein 6,gastrotropin,expressed in the ileum

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005215 transporter activity IEA--
GO:0005504 fatty acid binding IEA--
About this table

Pathways & Interactions
for FABP6

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


3 Sigma-Aldrich "Your Favorite Gene" Pathways for  FABP6  (Your Favorite Gene powered by Ingenuity) 
 Hepatic Cholestasis
 LPS/IL-1 Mediated Inhibition of RXR Function
 FXR/RXR Activation

   GeneDecks  FABP6 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for FABP6):
 hsa03320 PPAR signaling pathway

   GeneDecks  FABP6 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  FABP6 


5/45 Interacting proteins for FABP6 (ENSP000003122833) via UniProtKB, MINT, and/or STRING (see all 45 )
InteractantInteraction Details
GeneCardExternal ID(s)
SLC10A2ENSP000002453123STRING (score=.989)
NR1H4ENSP000001884033STRING (score=.983)
SLC10A1ENSP000002165403STRING (score=.98)
ABCC3ENSP000002852383STRING (score=.956)
FABP5L8ENSP000002972583STRING (score=.934)
About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006629 lipid metabolic process NAS9250612
GO:0006810 transport IEA--
GO:0008202 steroid metabolic process IEA--
GO:0008285 negative regulation of cell proliferation TAS9250612
About this table

Drugs & Compounds
for FABP6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FABP6
8 Novoseek chemical compound relationships for FABP6 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
gw 4064 79.41 2 15309887 (1), 17047076 (1)
deoxycholic acid 65.57 1 14529265 (1)
cholesterol 46.84 18 11684682 (5), 14770367 (3), 12479580 (2), 10334992 (1) (see all 6)
fatty acid 43.02 18 12479567 (2), 16951225 (2), 12486725 (1), 10653629 (1) (see all 8)
sterol 35.40 5 12479580 (1), 11684682 (1), 14770367 (1)
lipid 28.85 23 16237211 (2), 17618650 (2), 18469300 (1), 8789718 (1) (see all 10)
taurine 25.21 1 14529265 (1)
oleic acid 22.51 1 7588781 (1)
About this table


Transcripts
for FABP6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (FABP6)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FABP6)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001445

              Sigma-Aldrich siRNA for FABP6  
                     Sigma-Aldrich shRNA for FABP6  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001040442  NM_001130958  NM_001445  

REFSEQ mRNAs for FABP6 gene (3 alternative transcripts): 

NM_001040442.1   NM_001130958.1   NM_001445.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001040442  NM_001130958  NM_001445  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001040442
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001040442
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001040442 

Additional cDNA sequence: 

BC022489.1 DQ132786.1 U19869.1 X90908.1 

4 DOTS entries:

DT.75184141  DT.308000  DT.95090225  DT.91740229 

24/34 AceView cDNA sequences (see all 34 ):

AA953208 AI311734 BU683560 BM974219 NM_001445 AI744217 BV203713 BX098894 
AA873080 U19869 AI301666 AA960993 BC022489 BQ066098 BQ188379 BG192623 
AI765588 AI799578 BG208058 AA885617 BU502298 AI208231 AI689696 BG192082 

highest scoring ESTs for FABP6:

AA873080 AI311734 AI689696 AI744217 AI765588 AI799578 BC022489 BG184605 BG185264 BG186293 

Unigene Cluster for FABP6:

Fatty acid binding protein 6, ileal
Hs.519719  [show with all ESTs]
Unigene Representative Sequence: BG192623


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FABP6

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:              -     -                           
SP2:                    -                           
SP3:                                                

About this scheme

ECgene alternative splicing isoforms for FABP6

4 Ensembl transcripts including schematic representations:
ENST00000402432  ENST00000310650  ENST00000393980  ENST00000393982  

Expression
for FABP6

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FABP6 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FABP6

1 / 2 / 3

4 probe-sets matching FABP6 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

36779_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X90908 0.80 1.00 0.91 1

210445_at2, 3 U133-A 1 1.00 1.00 -- -- U19869 0.80 1.00 0.91 1

210445_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1566123_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGTGAGCCGG

SOURCE GeneReport for Unigene cluster: Hs.519719

Expression variation in blood from EXPOLDB for FABP6

Orthologs
for FABP6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for FABP6 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 FABP61   -- fatty acid binding protein 6, ileal 85.94(n)
78.12(a)		 479309  XM_536447.2  XP_536447.1 
chimpanzee
(Pan troglodytes)		 FABP61   -- fatty acid binding protein 6, ileal 99.06(n)
98.31(a)		 462233  XM_518071.2  XP_518071.2 
cow
(Bos taurus)		 FABP61   -- fatty acid binding protein 6, ileal 82.03(n)
70.31(a)		 514650  NM_001075675.1  NP_001069143.1 
rat
(Rattus norvegicus)		 Fabp61   -- fatty acid binding protein 6, ileal 80.99(n)
78.12(a)		 25440  NM_017098.1  NP_058794.1 
mouse
(Mus musculus)		 Fabp61, 5 11 (24.00 cM)5
 fatty acid binding protein 6, ileal (gastrotropin)1, 5 81.51(n)1
79.69(a)1		 162041  NM_008375.11  NP_032401.11 
 AL6704725  BC1192895  (see all 7)
About this table        Species with no ortholog for FABP6

ENSEMBL Gene Tree for FABP6

Paralogs
for FABP6

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FABP6 gene
FABP12  

SNPs/Variants
for FABP6

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/406 NCBI SNPs in FABP6 are shown (see all 406 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 80)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs22779531,2
A,C,F,O159598311(-) GGAGCA/GAGCAG 2 -- ng311Minor allele frequency- G:0.41EA 1492
rs44555971,2
C,F,H159588772(+) TTTGGC/TTGCAG 2 -- ng51 int14Minor allele frequency- T:0.07EU EA WA 420
rs119583831,2
F,H159557383(+) GAGCTG/AGAAGG 1 -- ng514Minor allele frequency- A:0.01EU EA WA 398
--
rs43100091,2
A,C159587404(+) CAtGAC/Tgtgtg 2 -- ng51 int10--------
--
rs68887611,2
A,C159558188(+) agtgtG/Tcacgg 1 -- ng510--------
--
rs117461791,2
A,C159587694(+) ATAATC/TGGCCG 2 -- int1 ng510--------
--
rs100718711,2
A,C159598304(+) ACAGAC/TGCTGC 3 -- ut31 ese30--------
--
rs77201491,2
H159589204(+) GAAGCT/ACCTTG 3 H/L mis14Minor allele frequency- A:0.00EU EA WA 404
--
rs11304351,2
F159591851(+) CAAGAC/TGTTCA 3 T/M mis1 ese35Minor allele frequency- T:0.45MN EU EA WA 442
--
rs119583411,2
C159557202(+) ttatgC/Ggggct 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for FABP6 (up to first 250kb)

Disorders & Mutations
for FABP6

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 600422

2 Novoseek disease relationships for FABP6 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver 23.09 4 12479567 (1), 16385255 (1)
colorectal cancer 7.85 5 17909007 (2), 16951225 (1)
About this table

Human Genome Epidemiology Navigator: FABP6 (1 document)

Medical News
for FABP6

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for FABP6

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/66 PubMed articles for FABP6 gene (see all 66 ):

Search for FABP6

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing FABP6

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 2172 HGNC: 3561 AceView: FABP6 Ensembl:ENSG00000170231 euGenes: HUgn2172
ECgene: FABP6 H-InvDB: FABP6

Other Databases showing FABP6

(According to HUGE)
About This Section

   --

Specialized Databases showing FABP6

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for FABP6

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for FABP6

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FABP6:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(FABP6)
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 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for FABP6




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for FABP6

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