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Aliases for FABP6 Gene

Aliases for FABP6 Gene

  • Fatty Acid Binding Protein 6, Ileal 2 3
  • ILLBP 3 4 6
  • Ileal Bile Acid Binding Protein 2 3
  • Illeal Lipid-Binding Protein 2 3
  • Ileal Lipid-Binding Protein 3 4
  • Intestinal 15 KDa Protein 3 4
  • Gastrotropin 2 3
  • I-BABP 3 4
  • I-15P 3 4
  • ILBP 3 4
  • GT 3 4
  • Intestinal Bile Acid-Binding Protein 4
  • Fatty Acid-Binding Protein 6 4
  • I-BALB 3
  • I-BAP 3
  • ILBP3 3

External Ids for FABP6 Gene

Previous GeneCards Identifiers for FABP6 Gene

  • GC05P159759
  • GC05P159549
  • GC05P159621
  • GC05P159573
  • GC05P154708

Summaries for FABP6 Gene

Entrez Gene Summary for FABP6 Gene

  • This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP6 Gene

FABP6 (Fatty Acid Binding Protein 6, Ileal) is a Protein Coding gene. Diseases associated with FABP6 include colorectal adenocarcinoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is FABP1.

UniProtKB/Swiss-Prot for FABP6 Gene

  • Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Gene Wiki entry for FABP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP6 Gene

Genomics for FABP6 Gene

Regulatory Elements for FABP6 Gene

Genomic Location for FABP6 Gene

Start:
160,187,367 bp from pter
End:
160,238,735 bp from pter
Size:
51,369 bases
Orientation:
Plus strand

Genomic View for FABP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP6 Gene

Proteins for FABP6 Gene

  • Protein details for FABP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51161-FABP6_HUMAN
    Recommended name:
    Gastrotropin
    Protein Accession:
    P51161
    Secondary Accessions:
    • Q07DR7
    • Q8TBI3
    • Q9UGI7

    Protein attributes for FABP6 Gene

    Size:
    128 amino acids
    Molecular mass:
    14371 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FABP6 Gene

    Alternative splice isoforms for FABP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FABP6 Gene

Proteomics data for FABP6 Gene at MOPED

Post-translational modifications for FABP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP6 Gene

Domains for FABP6 Gene

Gene Families for FABP6 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Protein Domains for FABP6 Gene

Suggested Antigen Peptide Sequences for FABP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51161

UniProtKB/Swiss-Prot:

FABP6_HUMAN :
  • P51161
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP6: view

Function for FABP6 Gene

Molecular function for FABP6 Gene

GENATLAS Biochemistry: fatty acid binding protein 6,gastrotropin,expressed in the ileum
UniProtKB/Swiss-Prot Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
UniProtKB/Swiss-Prot Induction: Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2 is up-regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in all stages of colorectal adenocarcinoma.

Gene Ontology (GO) - Molecular Function for FABP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP6: view

Phenotypes for FABP6 Gene

genes like me logo Genes that share phenotypes with FABP6: view

Animal Models for FABP6 Gene

MGI Knock Outs for FABP6:

Animal Model Products

CRISPR Products

miRNA for FABP6 Gene

miRTarBase miRNAs that target FABP6

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FABP6 Gene

Localization for FABP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP6 Gene

Isoform 1: Cytoplasm.
Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP6 Gene COMPARTMENTS Subcellular localization image for FABP6 gene
Compartment Confidence
cytosol 4
golgi apparatus 4
nucleus 4
mitochondrion 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FABP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 7588781
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP6: view

Pathways for FABP6 Gene

genes like me logo Genes that share pathways with FABP6: view

Pathways by source for FABP6 Gene

PCR Array Products

Interacting Proteins for FABP6 Gene

Gene Ontology (GO) - Biological Process for FABP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 9250612
GO:0008206 bile acid metabolic process TAS --
GO:0008285 negative regulation of cell proliferation TAS 9250612
GO:0015721 bile acid and bile salt transport TAS --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP6: view

Compounds for FABP6 Gene

(85) HMDB Compounds for FABP6 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(3) Drugbank Compounds for FABP6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target
N-Cholylglycine
475-31-0 target
Taurocholic Acid
81-24-3 target

(13) Novoseek inferred chemical compound relationships for FABP6 Gene

Compound -log(P) Hits PubMed IDs
gw 4064 77.8 2
glycocholate 74.3 5
chenodeoxycholic acid 72.3 4
deoxycholic acid 64.7 1
taurocholate 54.8 2
genes like me logo Genes that share compounds with FABP6: view

Transcripts for FABP6 Gene

Unigene Clusters for FABP6 Gene

Fatty acid binding protein 6, ileal:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -
SP3:

Relevant External Links for FABP6 Gene

GeneLoc Exon Structure for
FABP6
ECgene alternative splicing isoforms for
FABP6

Expression for FABP6 Gene

mRNA expression in normal human tissues for FABP6 Gene

mRNA differential expression in normal tissues according to GTEx for FABP6 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (41.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FABP6 Gene

SOURCE GeneReport for Unigene cluster for FABP6 Gene Hs.519719

mRNA Expression by UniProt/SwissProt for FABP6 Gene

P51161-FABP6_HUMAN
Tissue specificity: Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
genes like me logo Genes that share expressions with FABP6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FABP6 Gene

Orthologs for FABP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP6 35
  • 99.25 (n)
  • 98.87 (a)
FABP6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP6 35
  • 82.03 (n)
  • 70.31 (a)
FABP6 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP6 35
  • 85.94 (n)
  • 78.12 (a)
FABP6 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp6 35
  • 81.51 (n)
  • 79.69 (a)
Fabp6 16
Fabp6 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FABP6 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp6 35
  • 80.99 (n)
  • 78.12 (a)
chicken
(Gallus gallus)
Aves FABP6 35
  • 65.89 (n)
  • 63.28 (a)
FABP6 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP6 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487630 35
  • 63.52 (n)
  • 62.2 (a)
zebrafish
(Danio rerio)
Actinopterygii fabp6 35
  • 66.67 (n)
  • 59.32 (a)
fabp6 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4471 36
  • 32 (a)
OneToMany
Species with no ortholog for FABP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FABP6 Gene

ENSEMBL:
Gene Tree for FABP6 (if available)
TreeFam:
Gene Tree for FABP6 (if available)

Paralogs for FABP6 Gene

Paralogs for FABP6 Gene

Selected SIMAP similar genes for FABP6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FABP6: view

Variants for FABP6 Gene

Sequence variations from dbSNP and Humsavar for FABP6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs870517 -- 160,201,626(-) gggaA(A/T)CCCAC intron-variant
rs888917 -- 160,201,752(-) AATGA(A/G)TGAGT intron-variant
rs888918 -- 160,201,106(-) actgt(A/T)gggat intron-variant
rs888919 -- 160,201,001(-) tcata(C/T)gtgta intron-variant
rs888920 -- 160,186,921(-) GATCC(A/G)CCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FABP6 Gene

Variant ID Type Subtype PubMed ID
dgv359n21 CNV Loss 19592680

Relevant External Links for FABP6 Gene

HapMap Linkage Disequilibrium report
FABP6
Human Gene Mutation Database (HGMD)
FABP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP6 Gene

Disorders for FABP6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FABP6 Gene including...

Search for FABP6 Gene in MalaCards »

(2) Novoseek inferred disease relationships for FABP6 Gene

Disease -log(P) Hits PubMed IDs
fatty liver 20.1 2
colorectal cancer 5.64 3

Relevant External Links for FABP6

Genetic Association Database (GAD)
FABP6
Human Genome Epidemiology (HuGE) Navigator
FABP6
genes like me logo Genes that share disorders with FABP6: view

No data available for UniProtKB/Swiss-Prot for FABP6 Gene

Publications for FABP6 Gene

  1. Cloning and chromosomal localization of the human ileal lipid-binding protein. (PMID: 7619861) Oelkers P. … Dawson P.A. (Biochim. Biophys. Acta 1995) 2 3 4 23
  2. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M. … Kramer W. (Proteins 2003) 3 4 23 26
  3. A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. (PMID: 17909007) Fang C. … Smith J.W. (Cancer Res. 2007) 3 4 23
  4. Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals. (PMID: 19744871) Fisher E. … DAPring F. (Mol. Genet. Metab. 2009) 3 23 48
  5. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. (PMID: 7588781) Fujita M. … Ono T. (Eur. J. Biochem. 1995) 3 4 23

Products for FABP6 Gene

Sources for FABP6 Gene

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