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FABP6 Gene

protein-coding   GIFtS: 64
GCID: GC05P159573

Fatty Acid Binding Protein 6, Ileal

  See FABP6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Binding Protein 6, Ileal1 2     I-15P2 3
ILLBP2 3 5     I-BABP2 3
gastrotropin1 2     ILBP2 3
Ileal Bile Acid Binding Protein1 2     I-BALB2
Illeal Lipid-Binding Protein1 2     I-BAP2
Ileal Lipid-Binding Protein2 3     ILBP32
Intestinal 15 KDa Protein2 3     Fatty Acid-Binding Protein 63
GT2 3     Intestinal Bile Acid-Binding Protein3

External Ids:    HGNC: 35611   Entrez Gene: 21722   Ensembl: ENSG000001702317   OMIM: 6004225   UniProtKB: P511613   

Export aliases for FABP6 gene to outside databases

Previous GC identifers: GC05P159759 GC05P160150 GC05P159549 GC05P159621 GC05P154708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FABP6 Gene:
This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly
conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1
(the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include
fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters
and/or alternate splicing have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FABP6 Gene:
FABP6 (fatty acid binding protein 6, ileal) is a protein-coding gene. Diseases associated with FABP6 include colorectal adenocarcinoma. GO annotations related to this gene include lipid binding and transporter activity. An important paralog of this gene is FABP1.

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile
salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced
apoptosis

Gene Wiki entry for FABP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FABP6 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FABP6 promoter sequence
   Search Chromatin IP Primers for FABP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FABP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3-q34   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q23-q35

FABP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159573:  view genomic region     (about GC identifiers)

Start:
159,614,374 bp from pter      End:
159,665,742 bp from pter
Size:
51,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161 (See protein sequence)
Recommended Name: Gastrotropin  
Size: 128 amino acids; 14371 Da
Sequence caution: Sequence=AAH22489.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for FABP6:
1O1U (3D)        1O1V (3D)    
Secondary accessions: Q07DR7 Q8TBI3 Q9UGI7
Alternative promoter usage: 2 isoforms:  P51161-1   P51161-2   

Explore the universe of human proteins at neXtProt for FABP6: NX_P51161

Explore proteomics data for FABP6 at MOPED


See FABP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001035532.1  NP_001124430.1  NP_001436.1  

ENSEMBL proteins: 
 ENSP00000377549   ENSP00000428766   ENSP00000385433   ENSP00000377551  
Reactome Protein details: P51161

FABP6 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FABP: Fatty acid binding protein family

3 InterPro protein domains:
 IPR012674 Calycin
 IPR011038 Calycin-like
 IPR000463 Fatty_acid-bd

Graphical View of Domain Structure for InterPro Entry P51161

ProtoNet protein and cluster: P51161

1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


Find genes that share domains with FABP6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FABP6_HUMAN, P51161
Function: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile
salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced
apoptosis
Induction: Isoform 1 is up-regulated by chenodeoxycholic acid (CDCA) via the FXR transcription pathway. Isoform 2
is up-regulated by NF-kappa-B and in all stages of colorectal adenocarcinoma. Isoform 1 is not up-regulated in
all stages of colorectal adenocarcinoma

     Genatlas biochemistry entry for FABP6:
fatty acid binding protein 6,gastrotropin,expressed in the ileum

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
GO:0008289lipid binding IEA--
     
Find genes that share ontologies with FABP6           About GenesLikeMe


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fabp6):
 homeostasis/metabolism  liver/biliary system 

Find genes that share phenotypes with FABP6           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Fabp6tm1Lbal for FABP6

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FABP6
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miRNA
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hsa-mir-335-5p (MIRT016870)

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GenScript: all cDNA clones in your preferred vector (see all 3): FABP6 (NM_001130958)
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FABP6_HUMAN, P51161: Isoform 1: Cytoplasm
FABP6_HUMAN, P51161: Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and
neoplastic cells
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
golgi apparatus4
nucleus4
mitochondrion2
endoplasmic reticulum1
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----
GO:0005737cytoplasm TAS7588781
GO:0005794Golgi apparatus ----
GO:0005829cytosol TAS--

Find genes that share ontologies with FABP6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FABP6 About    
See pathways by source

SuperPathContained pathways About
1Synthesis of bile acids and bile salts
Bile acid and bile salt metabolism0.73
Recycling of bile acids and salts0.00
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
3PPAR signaling pathway
PPAR signaling pathway


Find genes that share SuperPaths with FABP6           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for FABP6
    Recycling of bile acids and salts


1 Kegg Pathway  (Kegg details for FABP6):
    PPAR signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP6: 
          Fatty Acid Metabolism in human mouse rat
          PPAR Targets in human mouse rat

Interactions:

    GeneGlobe Interaction Network for FABP6

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for FABP6 (P511613 ENSP000003775494) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
LGALS2P051623, ENSP000002158864I2D: score=1 STRING: ENSP00000215886
ABCC3ENSP000002852384STRING: ENSP00000285238
ALBENSP000002958974STRING: ENSP00000295897
SLC10A1ENSP000002165404STRING: ENSP00000216540
SLC10A2ENSP000002453124STRING: ENSP00000245312
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006629lipid metabolic process NAS9250612
GO:0008206bile acid metabolic process TAS--
GO:0008285negative regulation of cell proliferation TAS9250612
GO:0015721bile acid and bile salt transport TAS--
GO:0044281small molecule metabolic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FABP6

Selected HMDB Compounds for FABP6 (see all 85)    About this table
CompoundSynonyms CAS #PubMed Ids
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-412486725
1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-112486725
1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-712486725
12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-012486725
12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-112486725
12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-612486725
1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-812486725
1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-612486725
1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-112486725
2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-812486725

3 DrugBank Compounds for FABP6    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
N-Cholylglycine-- 475-31-0target--17139284 17016423 10592235
Taurocholic Acid-- 81-24-3target--17139284 17016423
Cholic Acid-- 81-25-4target--10592235

Selected Novoseek inferred chemical compound relationships for FABP6 gene (see all 13)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gw 4064 77.8 2 15309887 (1), 17047076 (1)
glycocholate 74.3 6 16411748 (3), 16230354 (1), 14529265 (1)
chenodeoxycholic acid 72.3 4 15309887 (1), 16230354 (1), 11254888 (1), 14529265 (1)
deoxycholic acid 64.7 1 14529265 (1)
taurocholate 54.8 3 12486725 (1), 10514450 (1)
cholesterol 50.8 18 11684682 (5), 14770367 (3), 12479580 (2), 10334992 (1) (see all 6)
cholestyramine 48.5 2 10514450 (1), 9461519 (1)
fatty acid 44.2 20 12479567 (2), 19744871 (2), 16951225 (2), 12486725 (1) (see all 9)
palmitate 36.4 2 7588781 (1), 9461519 (1)
sterol 33.8 5 12479580 (1), 11684682 (1), 14770367 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FABP6 gene (3 alternative transcripts): 
NM_001040442.1  NM_001130958.1  NM_001445.2  

Unigene Cluster for FABP6:

Fatty acid binding protein 6, ileal
Hs.519719  [show with all ESTs]
Unigene Representative Sequence: BG192623
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000393980(uc003lxx.1) ENST00000523955 ENST00000402432(uc003lya.1)
ENST00000521362 ENST00000393982(uc003lxz.1)
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  QuantiFast Probe-based Assays in human, mouse, rat FABP6

Additional mRNA sequence: 

BC022489.1 DQ132786.1 U19869.1 X90908.1 

4 DOTS entries:

DT.75184141  DT.308000  DT.95090225  DT.91740229 

Selected AceView cDNA sequences (see all 34):

AI744217 AA953208 NM_001445 BU683560 AI311734 BM974219 BQ188379 AA960993 
BC022489 BQ066098 BX098894 AI301666 AA873080 BV203713 BG192623 U19869 
AI208231 AI799578 BU502298 AA885617 BG208058 AI765588 AI689696 AI208908 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FABP6    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:              -     -                           
SP2:                    -                           
SP3:                                                


ECgene alternative splicing isoforms for FABP6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FABP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTGAGCCGG
FABP6 Expression
About this image

FABP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FABP6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.519719

UniProtKB/Swiss-Prot: FABP6_HUMAN, P51161
Tissue specificity: Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at
protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is
expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon,
sigmoid colon and rectum

    Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP6: 
          Fatty Acid Metabolism in human mouse rat
          PPAR Targets in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for FABP6
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QuantiFast Probe-based Assays in human, mouse, rat FABP6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FABP6 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fabp61 , 5 fatty acid binding protein 6, ileal (gastrotropin)1, 5 81.51(n)1
79.69(a)1
  11 (25.81 cM)5
162041  NM_008375.21  NP_032401.11 
 435960495 
chicken
(Gallus gallus)
Aves FABP61 fatty acid binding protein 6, ileal 65.89(n)
63.28(a)
  416154  NM_001277700.1  NP_001264629.1 
lizard
(Anolis carolinensis)
Reptilia FABP66
fatty acid binding protein 6, ileal
65(a)
1 ↔ 1
GL343286.1(1149029-1158363)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004876301 gastrotropin-like 63.52(n)
62.2(a)
  100487630  XM_002940178.2  XP_002940224.2 
zebrafish
(Danio rerio)
Actinopterygii fabp61 fatty acid binding protein 6, ileal (gastrotropin) 66.67(n)
59.32(a)
  415166  NM_001002076.1  NP_001002076.1 


ENSEMBL Gene Tree for FABP6 (if available)
TreeFam Gene Tree for FABP6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FABP6 gene
FABP12  
2 SIMAP similar genes for FABP6 using alignment to 2 protein entries:     FABP6_HUMAN (see all proteins):
FABP1    FABP2

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FABP6 (see all 1370)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs773488521,2
C--154733022(+) AAGTT-/C/CTT 
        
TTTTT
4 -- int1 cds10--------
rs113144911,2
C--154748201(+) AAGCCT/-AAAAG 2 -- int11Minor allele frequency- -:0.50CSA 2
rs106264161,2
C--159615072(+) ATTTT-/AT/TA 
        
TTATT
1 -- int11CSA 2
rs343182341,2
C--159615073(+) TTTTT-/AT/TA 
        
TATTT
1 -- int11NA 2
rs582619911,2
C--159618097(+) AAAAA-/A/AA  
        
GCAAA
1 -- int10--------
rs342760611,2
C--159618823(+) AAAAA-/AA    
   
/AAAA
AAAAA
1 -- int11NA 2
rs30445421,2
C--159619341(+) GTCTT-/CT    
   T
/TCT
ATCCC
2 -- cds11NA 2
rs562758411,2
C--159620918(+) CTTGG-/GCGGTC 1 -- int10--------
rs119547221,2
C,A,H--159620966(+) tcgtcC/Ggggag 1 -- int10--------
rs119547831,2
C,H--159621163(+) tcattC/Gcccgg 1 -- int10--------

HapMap Linkage Disequilibrium report for FABP6 (159614374 - 159665742 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for FABP6:    About this table    
Variant IDTypeSubtypePubMed ID
dgv359n21CNV Loss19592680

Human Gene Mutation Database (HGMD): FABP6
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FABP6
DNA2.0 Custom Variant and Variant Library Synthesis for FABP6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600422    OMIM disorders: --

1 disease for FABP6:    
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colorectal adenocarcinoma


Find genes that share disorders with FABP6           About GenesLikeMe

2 Novoseek inferred disease relationships for FABP6 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver 20.1 4 12479567 (1), 16385255 (1)
colorectal cancer 5.64 5 17909007 (2), 16951225 (1)

Genetic Association Database (GAD): FABP6
Human Genome Epidemiology (HuGE) Navigator: FABP6 (5 documents)

Export disorders for FABP6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FABP6 gene, integrated from 10 sources (see all 81):
(articles sorted by number of sources associating them with FABP6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and chromosomal localization of the human ileal lipid-binding protein. (PubMed id 7619861)1, 2, 3, 9 Oelkers P. and Dawson P.A. (Biochim. Biophys. Acta 1995)
  2. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)1, 2, 6, 9 Kurz M....Kramer W. (Proteins 2003)
  3. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. (PubMed id 7588781)1, 2, 9 Fujita M.... Ono T. (Eur. J. Biochem. 1995)
  4. A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. (PubMed id 17909007)1, 2, 9 Fang C.... Smith J.W. (Cancer Res. 2007)
  5. Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals. (PubMed id 19744871)1, 4, 9 Fisher E....DAPring F. (Mol. Genet. Metab. 2009)
  6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  7. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PubMed id 17266179)1, 4 Fisher E....DAPring F. (amp 2007)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. (PubMed id 7894165)1, 3 Birkenmeier E.H....Gordon J.I. (Mamm. Genome 1994)
  10. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. (PubMed id 15936983)1, 9 Landrier J.F....Besnard P. (Biochim. Biophys. Acta 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2172 HGNC: 3561 AceView: FABP6 Ensembl:ENSG00000170231 euGenes: HUgn2172
ECgene: FABP6 Kegg: 2172 H-InvDB: FABP6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FABP6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FABP6 gene:
Search GeneIP for patents involving FABP6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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