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FABP5L2 Gene

pseudogene   GIFtS: 32

GC13P051439
fatty acid binding protein 5-like 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
E-FABP 3
PA-FABP 3
Descriptions
Fatty acid-binding protein 5 3
Psoriasis-associated fatty acid-binding protein homolog 3
fatty acid binding protein 5-like 2 2
External Ids
HGNC: 310601
Entrez Gene: 7291632
UniProtKB: A8MUU13
UniProtKB: Q014693
Ensembl: ENSG000001646877
Search outside databases for aliases for FABP5L2 gene

Previous GC identifer: GC13U900270

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
Function: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the
chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte
differentiation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 13q14.3

FABP5L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P051439:     (about GC identifiers)

Start:
51,438,821 bp from pter
End:
51,439,498 bp from pter
Size:
678 bases
Orientation:
plus strand

1 alternative location:
Chr8+ 82,355,326-82,359,567     
RefSeq DNA sequence:
NC_000013.9  NT_024524.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FB5L3_HUMAN, A8MUU1 (See protein sequence)
Recommended Name: Putative fatty acid-binding protein 5-like protein 3  
Size: 101 amino acids; 11299 Da
Caution: Although defined as a pseudogene by HGNC, it is clearly expressed

UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469 (See protein sequence)

Recommended Name: Fatty acid-binding protein, epidermal  
Size: 135 amino acids; 15164 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1B56 (3D)    1JJJ (3D)    

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2 (FABP5L3)




  • ENSEMBL proteins: 
    ENSP00000379647 ENSP00000297258 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Fatty Acid Binding Protein 5)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for FABP5L2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Fatty Acid Binding Protein 5), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for FABP5L2

    Assays for FABP5L2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR012674 Calycin
     IPR000463 Fatty_acid_bd
     IPR000566 Lipocln_cytFABP


       GeneDecks  FABP5L2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry A8MUU1
    Graphical View of Domain Structure for InterPro Entry Q01469

    ProtoNet protein and cluster: A8MUU1

    UniProtKB/Swiss-Prot: FB5L3_HUMAN, A8MUU1
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior (By
    similarity)
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

    UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Applied Biosystems Silencer® siRNAs for FABP5L2

                  Sigma-Aldrich siRNA for FABP5L2  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                    Browse Origene genome-wide validated SYBR primer pairs

    UniProtKB/Swiss-Prot: FB5L3_HUMAN, A8MUU1
    Function: High specificity for fatty acids (By similarity)

    UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
    Function: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the
    chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte
    differentiation

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  FABP5L2  (Your Favorite Gene powered by Ingenuity) 
     LPS/IL-1 Mediated Inhibition of RXR Function

       GeneDecks  FABP5L2 for the pathways selected above  
    About GeneDecksing


    5/19 Interacting proteins for FABP5L2 (ENSP000002972583 Q014691) via UniProtKB, MINT, and/or STRING (see all 19 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKAO149651EBI-1054073, EBI-448680
    FABP6ENSP000003122833STRING (score=.934)
    CACNA2D1ENSP000003493203STRING (score=.899)
    CBLENSP000002640333STRING (score=.899)
    DIO3ENSP000003522733STRING (score=.899)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FABP5L2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                    Browse Origene for 29mer shRNA kit in GFP-retroviral vector

                  Sigma-Aldrich siRNA for FABP5L2  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    XM_001132811  

                    Browse Origene for untagged/tagged cDNA clones in CMV expression vector

    Additional cDNA sequence: XM_001132811.2 

    1 DOTS entry:

    DT.95358544 

    Unigene Cluster for FABP5L2:

    Fatty acid binding protein 5-like 2
    Hs.646651  [show with all ESTs]
    Unigene Representative Sequence: XM_001132811


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000396359  ENST00000297258  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FABP5L2 expression in normal and diseased human tissues

    1 / 2

    2 probe-sets matching FABP5L2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    202345_s_at2 U133-A 12 1.00 0.14 -- -- -- -- -- -- --

    202345_s_at2 U133Plus2 12 1.00 0.14 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTCTAGGCAT

    SOURCE GeneReport for Unigene cluster: Hs.646651

    UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
    Tissue specificity: Keratinocytes; highly expressed in psoriatic skin

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FABP5L2 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FABP5L21   -- fatty acid binding protein 5-like 2 90.21(n)
    89.91(a)
    477923  XM_535112.2  XP_535112.2 
    chimpanzee
    (Pan troglodytes)
    FABP5L21   -- fatty acid binding protein 5-like 2 97.53(n)
    95.56(a)
    746909  XM_001168193.1  XP_001168193.1 
    rat
    (Rattus norvegicus)
    Fabp51   -- fatty acid binding protein 5, epidermal 78.27(n)
    77.78(a)
    140868  NM_145878.1  NP_665885.1 
    mouse
    (Mus musculus)
    Fabp51   -- fatty acid binding protein 5, epidermal 79.51(n)
    77.78(a)
    16592  NM_010634.2  NP_034764.1 
    About this table        Species with no ortholog for FABP5L2

    ENSEMBL Gene Tree for FABP5L2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FABP5L2 gene
    FABP32  FABP72  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

      --
    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    8 PubMed articles for FABP5L2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 729163 HGNC: 31060 Ensembl:ENSG00000164687 euGenes: HUgn729163 ECgene: FABP5L2
    H-InvDB: FABP5L2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FABP5L2:
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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