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Aliases for FABP5 Gene

Aliases for FABP5 Gene

  • Fatty Acid Binding Protein 5 (Psoriasis-Associated) 2 3
  • Psoriasis-Associated Fatty Acid-Binding Protein Homolog 3 4
  • Epidermal-Type Fatty Acid-Binding Protein 3 4
  • PA-FABP 3 4
  • PAFABP 3 6
  • E-FABP 3 4
  • EFABP 3 6
  • Fatty Acid-Binding Protein, Epidermal 3
  • Fatty Acid-Binding Protein 5 4
  • KFABP 3

External Ids for FABP5 Gene

Summaries for FABP5 Gene

Entrez Gene Summary for FABP5 Gene

  • This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

GeneCards Summary for FABP5 Gene

FABP5 (Fatty Acid Binding Protein 5 (Psoriasis-Associated)) is a Protein Coding gene. Diseases associated with FABP5 include psoriasis and bladder squamous cell carcinoma. Among its related pathways are PPAR signaling pathway. GO annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP5 Gene

  • High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation

Gene Wiki entry for FABP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP5 Gene

Genomics for FABP5 Gene

Genomic Location for FABP5 Gene

Start:
81,280,363 bp from pter
End:
81,284,777 bp from pter
Size:
4,415 bases
Orientation:
Plus strand

Genomic View for FABP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP5 Gene

Regulatory Elements for FABP5 Gene

Proteins for FABP5 Gene

  • Protein details for FABP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01469-FABP5_HUMAN
    Recommended name:
    Fatty acid-binding protein, epidermal
    Protein Accession:
    Q01469
    Secondary Accessions:
    • B2R4K0

    Protein attributes for FABP5 Gene

    Size:
    135 amino acids
    Molecular mass:
    15164 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP5 Gene

neXtProt entry for FABP5 Gene

Proteomics data for FABP5 Gene at MOPED

Post-translational modifications for FABP5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys17, Lys24, Lys34, Lys61, and Lys82

Other Protein References for FABP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP5 Gene

Domains for FABP5 Gene

Gene Families for FABP5 Gene

HGNC:
  • FABP :Fatty acid binding protein family

UniProtKB/Swiss-Prot:

FABP5_HUMAN
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior:
    • Q01469
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.:
    • Q01469
genes like me logo Genes that share domains with FABP5: view

Function for FABP5 Gene

Molecular function for FABP5 Gene

UniProtKB/Swiss-Prot Function: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation

Gene Ontology (GO) - Molecular Function for FABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005504 fatty acid binding IEA --
GO:0005515 protein binding IPI 12839573
GO:0008289 lipid binding TAS 1512466
genes like me logo Genes that share ontologies with FABP5: view
genes like me logo Genes that share phenotypes with FABP5: view

Animal Models for FABP5 Gene

MGI Knock Outs for FABP5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FABP5 Gene

Localization for FABP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP5 Gene COMPARTMENTS Subcellular localization image for FABP5 gene
Compartment Confidence
cytosol 3
extracellular 3
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with FABP5: view

Pathways for FABP5 Gene

SuperPathways for FABP5 Gene

Superpath Contained pathways
1 PPAR signaling pathway
genes like me logo Genes that share pathways with FABP5: view

Pathways by source for FABP5 Gene

1 KEGG pathway for FABP5 Gene

Gene Ontology (GO) - Biological Process for FABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IEA --
GO:0006629 lipid metabolic process TAS 8092987
GO:0006656 phosphatidylcholine biosynthetic process IEA --
GO:0008544 epidermis development TAS 1512466
GO:0009611 response to wounding IEA --
genes like me logo Genes that share ontologies with FABP5: view

Compounds for FABP5 Gene

(1) Drugbank Compounds for FABP5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Palmitic Acid
  • 1-Hexyldecanoic Acid
57-10-3 carrier

(11) Novoseek inferred chemical compound relationships for FABP5 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 73.6 53
retinoic acid 51.6 5
sodium dodecylsulfate 42.3 2
stearic acid 34.5 1
palmitate 33.1 1
genes like me logo Genes that share compounds with FABP5: view

Transcripts for FABP5 Gene

mRNA/cDNA for FABP5 Gene

Unigene Clusters for FABP5 Gene

Fatty acid binding protein 5 (psoriasis-associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FABP5 Gene

No ASD Table

Relevant External Links for FABP5 Gene

GeneLoc Exon Structure for
FABP5
ECgene alternative splicing isoforms for
FABP5

Expression for FABP5 Gene

mRNA expression in normal human tissues for FABP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP5 Gene

This gene is overexpressed in Esophagus - Mucosa (13.0), Vagina (9.9), and Cervix - Ectocervix (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FABP5 Gene

SOURCE GeneReport for Unigene cluster for FABP5 Gene Hs.408061

mRNA Expression by UniProt/SwissProt for FABP5 Gene

Q01469-FABP5_HUMAN
Tissue specificity: Keratinocytes; highly expressed in psoriatic skin
genes like me logo Genes that share expressions with FABP5: view

Orthologs for FABP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP5 36
  • 99.75 (n)
  • 100 (a)
FABP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP5 36
  • 90.37 (n)
  • 91.85 (a)
FABP5 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
FABP5 36
  • 92.05 (n)
  • 94.5 (a)
mouse
(Mus musculus)
Mammalia Fabp5 36
  • 80.49 (n)
  • 80 (a)
Fabp5 16
Fabp5 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FABP5 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FABP5 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp5 36
  • 80 (n)
  • 80.74 (a)
chicken
(Gallus gallus)
Aves FABP5 36
  • 70.13 (n)
  • 64.8 (a)
FABP5 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP5 37
  • 62 (a)
OneToOne
Species with no ortholog for FABP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FABP5 Gene

ENSEMBL:
Gene Tree for FABP5 (if available)
TreeFam:
Gene Tree for FABP5 (if available)

Paralogs for FABP5 Gene

Paralogs for FABP5 Gene

Selected SIMAP similar genes for FABP5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FABP5: view

Variants for FABP5 Gene

Sequence variations from dbSNP and Humsavar for FABP5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10098288 -- 81,284,723(+) GTGTG(G/T)TGGAT utr-variant-3-prime
rs75000489 -- 81,285,118(+) TATAA(A/G)TAATA downstream-variant-500B
rs78335799 -- 81,285,022(+) AGGTG(A/G)CTACA downstream-variant-500B
rs114158855 -- 81,284,952(+) GCCCT(A/G)TACTA downstream-variant-500B
rs115709614 -- 81,284,898(+) AATTT(A/G)TATAG downstream-variant-500B

Relevant External Links for FABP5 Gene

HapMap Linkage Disequilibrium report
FABP5

No data available for Structural Variations from Database of Genomic Variants (DGV) for FABP5 Gene

Disorders for FABP5 Gene

(11) Novoseek inferred disease relationships for FABP5 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 51.3 7
carcinoma squamous cell 35.2 10
breast cancer 6.03 3
skin diseases 5.2 2
shock 3.69 2

Relevant External Links for FABP5

Genetic Association Database (GAD)
FABP5
Human Genome Epidemiology (HuGE) Navigator
FABP5
genes like me logo Genes that share disorders with FABP5: view

No data available for UniProtKB/Swiss-Prot for FABP5 Gene

Publications for FABP5 Gene

  1. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. (PMID: 1512466) Madsen P.S. … Celis J.E. (J. Invest. Dermatol. 1992) 2 3 4 23
  2. Purification and characterization of the human epidermal fatty acid- binding protein: localization during epidermal cell differentiation in vivo and in vitro. (PMID: 8092987) Siegenthaler G. … Saurat J.-H. (Biochem. J. 1994) 3 4 23
  3. Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid-binding protein. (PMID: 10493790) Hohoff C. … van Tilbeurgh H. (Biochemistry 1999) 3 4 23
  4. Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin. (PMID: 9438903) Watanabe R. … Ono T. (J. Dermatol. Sci. 1997) 3 23
  5. PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. (PMID: 11113456) O'Shaughnessy R.F. … Watt F.M. (FEBS Lett. 2000) 3 23

Products for FABP5 Gene

  • antibodies-online proteins for FABP5
  • antibodies-online antibodies for FABP5
  • antibodies-online kits for FABP5

Sources for FABP5 Gene

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