Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FABP5 Gene

Aliases for FABP5 Gene

  • Fatty Acid Binding Protein 5 2 3
  • Fatty Acid Binding Protein 5 (Psoriasis-Associated) 2 3 5
  • Psoriasis-Associated Fatty Acid-Binding Protein Homolog 3 4
  • Epidermal-Type Fatty Acid-Binding Protein 3 4
  • PA-FABP 3 4
  • E-FABP 3 4
  • Fatty Acid-Binding Protein 5 4
  • PAFABP 3
  • EFABP 3
  • KFABP 3

External Ids for FABP5 Gene

Previous GeneCards Identifiers for FABP5 Gene

  • GC08P081070
  • GC08P082241
  • GC08P081915
  • GC08P082242
  • GC08P082355
  • GC08P077682

Summaries for FABP5 Gene

Entrez Gene Summary for FABP5 Gene

  • This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

GeneCards Summary for FABP5 Gene

FABP5 (Fatty Acid Binding Protein 5) is a Protein Coding gene. Diseases associated with FABP5 include psoriasis. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot for FABP5 Gene

  • High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.

Gene Wiki entry for FABP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP5 Gene

Genomics for FABP5 Gene

Regulatory Elements for FABP5 Gene

Promoters for FABP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FABP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FABP5 Gene

Chromosome:
8
Start:
81,280,363 bp from pter
End:
81,284,777 bp from pter
Size:
4,415 bases
Orientation:
Plus strand

Genomic View for FABP5 Gene

Genes around FABP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP5 Gene

Proteins for FABP5 Gene

  • Protein details for FABP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01469-FABP5_HUMAN
    Recommended name:
    Fatty acid-binding protein, epidermal
    Protein Accession:
    Q01469
    Secondary Accessions:
    • B2R4K0

    Protein attributes for FABP5 Gene

    Size:
    135 amino acids
    Molecular mass:
    15164 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP5 Gene

neXtProt entry for FABP5 Gene

Proteomics data for FABP5 Gene at MOPED

Post-translational modifications for FABP5 Gene

  • Ubiquitination at Lys 24, Lys 34, Lys 61, and Lys 82
  • Modification sites at PhosphoSitePlus

Other Protein References for FABP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP5 (FABP5)

No data available for DME Specific Peptides for FABP5 Gene

Domains & Families for FABP5 Gene

Gene Families for FABP5 Gene

Suggested Antigen Peptide Sequences for FABP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q01469

UniProtKB/Swiss-Prot:

FABP5_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP5: view

Function for FABP5 Gene

Molecular function for FABP5 Gene

UniProtKB/Swiss-Prot Function:
High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.

Gene Ontology (GO) - Molecular Function for FABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005504 fatty acid binding IEA --
GO:0005515 protein binding IPI 12839573
genes like me logo Genes that share ontologies with FABP5: view
genes like me logo Genes that share phenotypes with FABP5: view

Animal Models for FABP5 Gene

MGI Knock Outs for FABP5:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FABP5 Gene

Localization for FABP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP5 Gene COMPARTMENTS Subcellular localization image for FABP5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
peroxisome 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with FABP5: view

Pathways & Interactions for FABP5 Gene

genes like me logo Genes that share pathways with FABP5: view

Gene Ontology (GO) - Biological Process for FABP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006656 phosphatidylcholine biosynthetic process IEA --
GO:0008544 epidermis development TAS 1512466
GO:0009611 response to wounding IEA --
GO:0015758 glucose transport IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FABP5: view

No data available for SIGNOR curated interactions for FABP5 Gene

Drugs & Compounds for FABP5 Gene

(6) Drugs for FABP5 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Experimental Pharma Full agonist, Agonist, Carrier 20

(6) Additional Compounds for FABP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FABP5: view

Transcripts for FABP5 Gene

Unigene Clusters for FABP5 Gene

Fatty acid binding protein 5 (psoriasis-associated):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP5 Gene

No ASD Table

Relevant External Links for FABP5 Gene

GeneLoc Exon Structure for
FABP5
ECgene alternative splicing isoforms for
FABP5

Expression for FABP5 Gene

mRNA expression in normal human tissues for FABP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP5 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.0), Vagina (x9.9), and Cervix - Ectocervix (x6.9).

Protein differential expression in normal tissues from HIPED for FABP5 Gene

This gene is overexpressed in Oral epithelium (15.7) and Esophagus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FABP5 Gene



SOURCE GeneReport for Unigene cluster for FABP5 Gene Hs.408061

mRNA Expression by UniProt/SwissProt for FABP5 Gene

Q01469-FABP5_HUMAN
Tissue specificity: Keratinocytes; highly expressed in psoriatic skin.
genes like me logo Genes that share expression patterns with FABP5: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FABP5 Gene

Orthologs for FABP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FABP5 35
  • 90.37 (n)
  • 91.85 (a)
FABP5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP5 35
  • 92.05 (n)
  • 94.5 (a)
-- 36
  • 92 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fabp5 35
  • 80.49 (n)
  • 80 (a)
Fabp5 16
Fabp5 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FABP5 35
  • 99.75 (n)
  • 100 (a)
FABP5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp5 35
  • 80 (n)
  • 80.74 (a)
oppossum
(Monodelphis domestica)
Mammalia FABP5 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FABP5 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FABP5 35
  • 70.13 (n)
  • 64.8 (a)
FABP5 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP5 36
  • 62 (a)
OneToOne
Species with no ortholog for FABP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FABP5 Gene

ENSEMBL:
Gene Tree for FABP5 (if available)
TreeFam:
Gene Tree for FABP5 (if available)

Paralogs for FABP5 Gene

Paralogs for FABP5 Gene

(15) SIMAP similar genes for FABP5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FABP5: view

Variants for FABP5 Gene

Sequence variations from dbSNP and Humsavar for FABP5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs454550 -- 81,279,417(+) CATAA(C/G)GTCTT upstream-variant-2KB
rs391842 -- 81,279,768(+) AGAGG(A/G)AACCC upstream-variant-2KB
rs408070 -- 81,280,412(+) ACCCC(A/G)AGAAG upstream-variant-2KB
rs414930 -- 81,281,143(+) CCACT(C/T)CCCTT intron-variant
rs1062115 -- 81,280,075(+) ACCTT(A/C/G/T)TGCTC upstream-variant-2KB

Variation tolerance for FABP5 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP5 Gene

HapMap Linkage Disequilibrium report
FABP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FABP5 Gene

Disorders for FABP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FABP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search FABP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP5

Genetic Association Database (GAD)
FABP5
Human Genome Epidemiology (HuGE) Navigator
FABP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP5
genes like me logo Genes that share disorders with FABP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP5 Gene

Publications for FABP5 Gene

  1. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. (PMID: 1512466) Madsen P.S. … Celis J.E. (J. Invest. Dermatol. 1992) 2 3 4 23 67
  2. Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells. (PMID: 19434059) Wu T. … Handa J.T. (Lab. Invest. 2010) 3 23
  3. Fatty-acid-binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma. (PMID: 20040021) Fang L.Y. … Chen Y.L. (J. Oral Pathol. Med. 2010) 3 23
  4. Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. (PMID: 19337991) Melle C. … von Eggeling F. (Proteomics 2009) 3 23
  5. New horny layer marker proteins for evaluating skin condition in atopic dermatitis. (PMID: 19339807) Yamane Y. … Miyazaki K. (Int. Arch. Allergy Immunol. 2009) 3 23

Products for FABP5 Gene

Sources for FABP5 Gene

Back to Top

Content