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Aliases for FABP4 Gene

Aliases for FABP4 Gene

  • Fatty Acid Binding Protein 4, Adipocyte 2 3
  • Adipocyte-Type Fatty Acid-Binding Protein 3 4
  • Adipocyte Lipid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 4 3 4
  • A-FABP 3 4
  • AFABP 3 4
  • ALBP 3 4
  • Fatty Acid-Binding Protein, Adipocyte 3
  • Epididymis Secretory Protein Li 104 3
  • HEL-S-104 3
  • AP2 3

External Ids for FABP4 Gene

Previous GeneCards Identifiers for FABP4 Gene

  • GC08M081268
  • GC08M082439
  • GC08M082113
  • GC08M082440
  • GC08M082553
  • GC08M082390
  • GC08M077880

Summaries for FABP4 Gene

Entrez Gene Summary for FABP4 Gene

  • FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP4 Gene

FABP4 (Fatty Acid Binding Protein 4, Adipocyte) is a Protein Coding gene. Diseases associated with FABP4 include cerebellar liponeurocytoma and coronary restenosis. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP4 Gene

  • Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP4 Gene

Genomics for FABP4 Gene

Regulatory Elements for FABP4 Gene

Genomic Location for FABP4 Gene

Start:
81,478,419 bp from pter
End:
81,483,263 bp from pter
Size:
4,845 bases
Orientation:
Minus strand

Genomic View for FABP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP4 Gene

Proteins for FABP4 Gene

  • Protein details for FABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15090-FABP4_HUMAN
    Recommended name:
    Fatty acid-binding protein, adipocyte
    Protein Accession:
    P15090
    Secondary Accessions:
    • Q6IBA1

    Protein attributes for FABP4 Gene

    Size:
    132 amino acids
    Molecular mass:
    14719 Da
    Quaternary structure:
    • Homodimer. Interacts with PPARG (By similarity). Monomer.

    Three dimensional structures from OCA and Proteopedia for FABP4 Gene

neXtProt entry for FABP4 Gene

Proteomics data for FABP4 Gene at MOPED

Post-translational modifications for FABP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP4 (FABP4)

No data available for DME Specific Peptides for FABP4 Gene

Domains for FABP4 Gene

Gene Families for FABP4 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for FABP4 Gene

Graphical View of Domain Structure for InterPro Entry

P15090

UniProtKB/Swiss-Prot:

FABP4_HUMAN :
  • P15090
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP4: view

Function for FABP4 Gene

Molecular function for FABP4 Gene

GENATLAS Biochemistry: fatty acid-binding protein 4,adipocyte
UniProtKB/Swiss-Prot Function: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

Gene Ontology (GO) - Molecular Function for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005504 fatty acid binding TAS 2481498
genes like me logo Genes that share ontologies with FABP4: view
genes like me logo Genes that share phenotypes with FABP4: view

Animal Models for FABP4 Gene

MGI Knock Outs for FABP4:

Animal Model Products

CRISPR Products

miRNA for FABP4 Gene

miRTarBase miRNAs that target FABP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FABP4 Gene

Localization for FABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP4 Gene

Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP4 Gene COMPARTMENTS Subcellular localization image for FABP4 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
peroxisome 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005811 lipid particle TAS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FABP4: view

Pathways for FABP4 Gene

genes like me logo Genes that share pathways with FABP4: view

Pathways by source for FABP4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006810 transport IEA --
GO:0019433 triglyceride catabolic process TAS --
GO:0042632 cholesterol homeostasis IEA --
genes like me logo Genes that share ontologies with FABP4: view

Compounds for FABP4 Gene

(34) Novoseek inferred chemical compound relationships for FABP4 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 83 127
glycerol 3-phosphate 69 9
lipid 66.5 80
thiazolidinedione 61.2 4
rosiglitazone 61.2 4
genes like me logo Genes that share compounds with FABP4: view

Transcripts for FABP4 Gene

mRNA/cDNA for FABP4 Gene

Unigene Clusters for FABP4 Gene

Fatty acid binding protein 4, adipocyte:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for FABP4 Gene

GeneLoc Exon Structure for
FABP4
ECgene alternative splicing isoforms for
FABP4

Expression for FABP4 Gene

mRNA expression in normal human tissues for FABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (17.6), Adipose - Subcutaneous (15.7), and Breast - Mammary Tissue (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FABP4 Gene

SOURCE GeneReport for Unigene cluster for FABP4 Gene Hs.391561

genes like me logo Genes that share expressions with FABP4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FABP4 Gene

Orthologs for FABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP4 35
  • 99.75 (n)
  • 100 (a)
FABP4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP4 35
  • 89.39 (n)
  • 84.09 (a)
FABP4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
FABP4 35
  • 92.68 (n)
  • 94.7 (a)
mouse
(Mus musculus)
Mammalia Fabp4 35
  • 86.11 (n)
  • 91.67 (a)
Fabp4 16
Fabp4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 20 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fabp4 35
  • 83.84 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves FABP4 35
  • 73.48 (n)
  • 76.52 (a)
FABP4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pmp2 35
  • 60.05 (n)
  • 59.54 (a)
worm
(Caenorhabditis elegans)
Secernentea lbp-5 35
  • 50.51 (n)
  • 51.54 (a)
Species with no ortholog for FABP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FABP4 Gene

ENSEMBL:
Gene Tree for FABP4 (if available)
TreeFam:
Gene Tree for FABP4 (if available)

Paralogs for FABP4 Gene

Paralogs for FABP4 Gene

Selected SIMAP similar genes for FABP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FABP4: view

Variants for FABP4 Gene

Sequence variations from dbSNP and Humsavar for FABP4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs14044 -- 81,478,300(+) CCCAC(C/T)GGGGG downstream-variant-500B
rs1051231 -- 81,479,452(-) CAACC(A/C)CCATA reference, missense
rs1051252 -- 81,478,858(-) CCAAG(C/G)GACGT utr-variant-3-prime
rs1054135 -- 81,478,525(-) TAGGA(A/G)ATAAC utr-variant-3-prime
rs1486005 -- 81,478,314(+) tagaa(C/T)gtacc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FABP4 Gene

Variant ID Type Subtype PubMed ID
nsv891065 CNV Loss 21882294
nsv465721 CNV Gain 19166990
nsv891066 CNV Loss 21882294

Relevant External Links for FABP4 Gene

HapMap Linkage Disequilibrium report
FABP4
Human Gene Mutation Database (HGMD)
FABP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP4 Gene

Disorders for FABP4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for FABP4 Gene including...

Search for FABP4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for FABP4 Gene

(15) Novoseek inferred disease relationships for FABP4 Gene

Disease -log(P) Hits PubMed IDs
obesity 60.7 28
insulin resistance 59.8 24
insulin sensitivity 57.1 7
carcinoma transitional cell bladder 50.4 2
atherosclerosis 49.4 13

Relevant External Links for FABP4

Genetic Association Database (GAD)
FABP4
Human Genome Epidemiology (HuGE) Navigator
FABP4
genes like me logo Genes that share disorders with FABP4: view

No data available for UniProtKB/Swiss-Prot for FABP4 Gene

Publications for FABP4 Gene

  1. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PMID: 15015141) Damcott C.M. … Ferrell R.E. (Metab. Clin. Exp. 2004) 3 23 48
  2. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. (PMID: 20156355) Khalyfa A. … Gozal D. (Lipids Health Dis 2010) 3 23 48
  3. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. (PMID: 2481498) Baxa C.A. … Bernlohr D.A. (Biochemistry 1989) 2 3 4
  4. Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. (PMID: 19368945) Yun K.E. … Park H.S. (Metab. Clin. Exp. 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FABP4 Gene

Sources for FABP4 Gene

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