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FABP4 Gene

protein-coding   GIFtS: 68
GCID: GC08M082390

Fatty Acid Binding Protein 4, Adipocyte

  See FABP4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Binding Protein 4, Adipocyte1 2     ALBP2 3
Adipocyte Lipid-Binding Protein2 3     HEL-S-1042
Adipocyte-Type Fatty Acid-Binding Protein2 3     aP22
Fatty Acid-Binding Protein 42 3     Epididymis Secretory Protein Li 1042
A-FABP2 3     Fatty Acid-Binding Protein, Adipocyte2
AFABP2 3     

External Ids:    HGNC: 35591   Entrez Gene: 21672   Ensembl: ENSG000001703237   OMIM: 6004345   UniProtKB: P150903   

Export aliases for FABP4 gene to outside databases

Previous GC identifers: GC08M081268 GC08M082439 GC08M082113 GC08M082440 GC08M082553 GC08M077880


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FABP4 Gene:
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of
small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It
is thought that FABPs roles include fatty acid uptake, transport, and metabolism. (provided by RefSeq, Jul 2008)

GeneCards Summary for FABP4 Gene:
FABP4 (fatty acid binding protein 4, adipocyte) is a protein-coding gene. Diseases associated with FABP4 include cerebellar liponeurocytoma, and coronary restenosis. GO annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: FABP4_HUMAN, P15090
Function: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers
long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FABP4 gene promoter:
         PPAR-alpha   USF1   C/EBPbeta   AP-1   POU3F1   USF-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFABP4 promoter sequence
   Search Chromatin IP Primers for FABP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FABP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

FABP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082390:  view genomic region     (about GC identifiers)

Start:
82,390,654 bp from pter      End:
82,395,498 bp from pter
Size:
4,845 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FABP4_HUMAN, P15090 (See protein sequence)
Recommended Name: Fatty acid-binding protein, adipocyte  
Size: 132 amino acids; 14719 Da
Subunit: Homodimer. Interacts with PPARG (By similarity). Monomer
Selected PDB 3D structures from and Proteopedia for FABP4 (see all 15):
1TOU (3D)        1TOW (3D)        2HNX (3D)        2NNQ (3D)        3FR2 (3D)        3FR4 (3D)    
Secondary accessions: Q6IBA1

Explore the universe of human proteins at neXtProt for FABP4: NX_P15090

Explore proteomics data for FABP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FABP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001433.1  
    ENSEMBL proteins: 
     ENSP00000256104   ENSP00000428385  
    Reactome Protein details: P15090

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P15090

    ProtoNet protein and cluster: P15090

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABP4_HUMAN, P15090
    Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    Find genes that share domains with FABP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FABP4_HUMAN, P15090
    Function: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers
    long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity)

         Genatlas biochemistry entry for FABP4:
    fatty acid-binding protein 4,adipocyte

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005504fatty acid binding TAS2481498
         
    Find genes that share ontologies with FABP4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FABP4:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fabp4):
     adipose tissue  cardiovascular system  growth/size/body  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle 

    Find genes that share phenotypes with FABP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fabp4tm1Brsp for FABP4

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    miRTarBase miRNAs that target FABP4:
    hsa-mir-138-5p (MIRT005490), hsa-mir-335-5p (MIRT019040), hsa-mir-369-5p (MIRT005959)

    Block miRNA regulation of human, mouse, rat FABP4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FABP4:
    hsa-miR-1910 hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidFABP4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FABP4_HUMAN, P15090: Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change
    exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive
    nuclear export (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2
    peroxisome2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169
    GO:0005811lipid particle TAS--

    Find genes that share ontologies with FABP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FABP4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipid digestion, mobilization, and transport0.59
    Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    5Selected targets of C EBPbeta
    Selected targets of C EBPbeta


    Find genes that share SuperPaths with FABP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FABP4
        Glucose / Energy Metabolism


    2 Reactome Pathways for FABP4
        Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
    Transcriptional regulation of white adipocyte differentiation


    1 Kegg Pathway  (Kegg details for FABP4):
        PPAR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP4 (see all 6): 
              Lung Cancer in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FABP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FABP4 (P150902, 3 ENSP000002561044) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VIMP086702, 3, ENSP000002242374MINT-8255018 MINT-63478 I2D: score=5 STRING: ENSP00000224237
    ACTBP607092, 3, ENSP000003499604MINT-8254985 I2D: score=2 STRING: ENSP00000349960
    CHD3Q128732, 3MINT-8254996 I2D: score=2 
    PRKCIP417432, 3, ENSP000002957974MINT-8255007 I2D: score=2 STRING: ENSP00000295797
    ZBED1O960062, 3, ENSP000003706164MINT-8255029 I2D: score=2 STRING: ENSP00000370616
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0006469negative regulation of protein kinase activity IEA--
    GO:0019433triglyceride catabolic process TAS--
    GO:0042632cholesterol homeostasis IEA--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with FABP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for FABP4

    Selected DrugBank Compounds for FABP4 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Hexadecanosulfonic Acid-- 15015-81-3carrier--17139284 17016423 10592235
    2-[(2-Oxo-2-Piperidin-1-Ylethyl)Thio]-6-(Trifluoromethyl)Pyrimidin-4(1h)-One-- --carrier--17139284 17016423 10592235
    3-Sulfinoalanine-- 1115-65-7carrier--17139284 17016423 10592235
    Arachidonic Acid-- 506-32-1carrier--17139284 17016423 10592235
    Carbazole Butanoic Acid-- --carrier--17139284 17016423 10592235
    Cysteine-Methylene-Carbamoyl-1,10-Phenanthroline-- --carrier--17139284 17016423 10592235
    Oleic Acid-- 112-80-1carrier--17139284 17016423 10592235
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3carrier--17139284 17016423 10592235
    Propanoic Acid-- 79-09-4carrier--17139284 17016423 10592235
    (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE-- --carrier--10592235

    Selected Novoseek inferred chemical compound relationships for FABP4 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 83 218 9516437 (5), 8357805 (3), 7547918 (2), 15456755 (2) (see all 99)
    glycerol 3-phosphate 69 14 17242918 (1), 18448614 (1), 11983812 (1), 18652540 (1) (see all 9)
    lipid 66.5 129 12794068 (5), 16313911 (4), 8463311 (3), 12417276 (3) (see all 58)
    thiazolidinedione 61.2 5 17553506 (1), 11884404 (1), 7808426 (1), 9831621 (1)
    rosiglitazone 61.2 4 18068701 (1), 17993761 (1), 17242918 (1), 15710620 (1)
    15-deoxy-delta-12,14-prostaglandin j2 58.9 2 12417276 (1)
    oleic acid 48.7 11 2223772 (3), 1648089 (2), 16870193 (1), 8634281 (1) (see all 7)
    troglitazone 48 3 9709955 (1), 10935488 (1)
    glucose 46.9 39 17620449 (3), 20156355 (3), 17635574 (3), 16919044 (2) (see all 20)
    palmitate 45.8 5 8161548 (2), 19135148 (1), 20102700 (1)



    Find genes that share compounds with FABP4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FABP4 gene: 
    NM_001442.2  

    Unigene Cluster for FABP4:

    Fatty acid binding protein 4, adipocyte
    Hs.391561  [show with all ESTs]
    Unigene Representative Sequence: CB999901
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256104(uc003ycd.2) ENST00000518669 ENST00000522659 ENST00000521734

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    Additional mRNA sequence: 

    BC003672.1 BT006809.1 CR456903.1 J02874.1 

    8 DOTS entries:

    DT.217317  DT.100828346  DT.99971609  DT.100036595  DT.100740312  DT.100828347  DT.99995846  DT.91923234 

    Selected AceView cDNA sequences (see all 270):

    H42609 AI148406 AI493086 CA407624 BQ574690 AI094429 F15904 BU742829 
    BP381358 BQ720073 BQ017120 AA137055 BM740297 AA846215 AJ707063 AA046090 
    AI400113 AI127007 BM929515 F29476 BQ575807 BQ880795 AA126737 BQ951142 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FABP4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                          
    SP2:              -                           
    SP3:                                          


    ECgene alternative splicing isoforms for FABP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FABP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTAGCAAG
    FABP4 Expression
    About this image


    FABP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 27) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 40 entries
             Visceral White Adipocytes Visceral White Adipose
             White adipocyte-like cells
             Human Preadipocyte-subcutaneous (HPA-s)   
             Adipocyte   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced SK11 cells
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Pelvic Girdle
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    FABP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FABP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.391561
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP4 (see all 6): 
              Lung Cancer in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat
              PPAR Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FABP4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fabp41 , 5 fatty acid binding protein 4, adipocyte1, 5 86.11(n)1
    91.67(a)1
      3 (2.56 cM)5
    117701  NM_024406.21  NP_077717.11 
     102043475 
    chicken
    (Gallus gallus)
    Aves FABP41 fatty acid binding protein 4, adipocyte 73.48(n)
    76.52(a)
      374165  NM_204290.1  NP_989621.1 
    lizard
    (Anolis carolinensis)
    Reptilia FABP46
    fatty acid binding protein 4, adipocyte
    63(a)
    1 ↔ 1
    4(24482953-24493834)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pmp21 peripheral myelin protein 2 60.05(n)
    59.54(a)
      100135411  NM_001114072.1  NP_001107544.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-51 lbp-5 50.51(n)
    51.54(a)
      191700  NM_059527.3  NP_491928.1 


    ENSEMBL Gene Tree for FABP4 (if available)
    TreeFam Gene Tree for FABP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FABP4 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP32  RBP12  RBP22  
    CRABP12  FABP22  PMP22  FABP72  RBP72  
    15 SIMAP similar genes for FABP4 using alignment to 3 protein entries:     FABP4_HUMAN (see all proteins):
    FABP9    PMP2    DKFZp547J2313    FABP3    FABP7    FABP5
    FABP12    FABP5P3    CRABP2    RBP1    FABP2    RBP2
    RBP5    RBP7    CRABP1

    Find genes that share paralogs with FABP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FABP4 (see all 201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363204
    A breast cancer sample4--see VAR_0363202 E D mis40--------
    rs101094801,2
    C,F,H--82390244(+) CACGAC/GAATAA 1 -- ds500128Minor allele frequency- G:0.45NS EA NA WA CSA 2985
    rs140441,2
    C,F--82390535(+) CCCACT/CGGGGG 1 -- ds500112Minor allele frequency- C:0.46MN NA WA CSA EA 742
    rs14860051,2
    A,H--82390549(+) tagaaT/Cgtacc 1 -- ds50015Minor allele frequency- C:0.00MN NS EA 600
    rs1385025451,2
    --82390614(+) CAGAGA/CGGGTA 1 -- ds50010--------
    rs14860061,2
    C,F,O,H--82390617(+) AGCGGG/CTATAA 1 -- ds500119Minor allele frequency- C:0.13MN NS EA NA WA CSA 1529
    rs169091871,2
    C,F,H--82390717(+) CTATGG/ATAAAG 1 -- ds500124Minor allele frequency- A:0.16NA NS EA WA CSA 2489
    rs10541351,2
    C,F,O,A,H--82390760(-) TAGGAG/AATAAC 1 -- ut3122Minor allele frequency- A:0.32MN NS EA NA WA 2664
    rs784739291,2
    C,F--82390780(+) ATCCAT/CAGATA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs169091921,2
    C,F,H--82390843(+) AAGAAA/CTAATG 1 -- ut3116Minor allele frequency- C:0.09NA NS EA WA 2030

    HapMap Linkage Disequilibrium report for FABP4 (82390654 - 82395498 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FABP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891066CNV Loss21882294
    nsv891065CNV Loss21882294
    nsv465721CNV Gain19166990

    Human Gene Mutation Database (HGMD): FABP4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FABP4
    DNA2.0 Custom Variant and Variant Library Synthesis for FABP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600434    OMIM disorders: --

    7 diseases for FABP4:    
    About MalaCards
    cerebellar liponeurocytoma    coronary restenosis    back pain    obstructive sleep apnea
    familial combined hyperlipidemia    insulin resistance    obesity

    2 diseases from the University of Copenhagen DISEASES database for FABP4:
    Atherosclerosis     Diabetes mellitus

    Find genes that share disorders with FABP4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FABP4 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 60.7 39 20156355 (4), 19368945 (4), 17656598 (4), 19842034 (2) (see all 17)
    insulin resistance 59.8 33 19368945 (5), 17389279 (3), 19475694 (2), 16423904 (2) (see all 15)
    insulin sensitivity 57.1 7 15015141 (2), 18063851 (1), 18436985 (1), 19197257 (1) (see all 6)
    carcinoma transitional cell bladder 50.4 3 8840999 (1), 15734831 (1)
    atherosclerosis 49.4 18 17510463 (3), 17396233 (1), 15686734 (1), 16423904 (1) (see all 11)
    carcinoma transitional cell 24.8 2 19115207 (1)
    bladder cancer 24.2 12 19115207 (2), 15734831 (1), 10935488 (1)
    cardiovascular diseases 17 7 16423904 (1), 18419784 (1), 17389279 (1), 18849305 (1) (see all 5)
    inflammation 15.4 13 19475694 (4), 17656598 (2), 20156355 (1), 19217286 (1)
    necrosis 8.31 2 15500004 (1), 17998029 (1)

    Genetic Association Database (GAD): FABP4
    Human Genome Epidemiology (HuGE) Navigator: FABP4 (15 documents)

    Export disorders for FABP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FABP4 gene, integrated from 10 sources (see all 306):
    (articles sorted by number of sources associating them with FABP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. (PubMed id 2481498)1, 2, 3 Baxa C.A.... Bernlohr D.A. (Biochemistry 1989)
    2. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. (PubMed id 20156355)1, 4, 9 Khalyfa A....Gozal D. (Lipids Health Dis 2010)
    3. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PubMed id 15015141)1, 4, 9 Damcott C.M....Ferrell R.E. (Metab. Clin. Exp. 2004)
    4. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. (PubMed id 20413122)1, 4 SolA R....Anguera A. (Atherosclerosis 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Common genetic variants in fatty acid-binding protein-4 (FABP4) and clinical diabetes risk in the Women's Health Initiative Observational Study. (PubMed id 20111020)1, 4 Chan K.H....Liu S. (Obesity (Silver Spring) 2010)
    7. FABP4: a novel candidate gene for polycystic ovary syndrome. (PubMed id 19844814)1, 4 Wang J....Cao Y. (Endocrine 2009)
    8. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    9. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (Lymphat Res Biol 2008)
    10. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2167 HGNC: 3559 AceView: FABP4 Ensembl:ENSG00000170323 euGenes: HUgn2167
    ECgene: FABP4 Kegg: 2167 H-InvDB: FABP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FABP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FABP4 gene:
    Search GeneIP for patents involving FABP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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