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Aliases for FABP4 Gene

Aliases for FABP4 Gene

  • Fatty Acid Binding Protein 4, Adipocyte 2 3
  • Adipocyte-Type Fatty Acid-Binding Protein 3 4
  • Adipocyte Lipid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 4 3 4
  • A-FABP 3 4
  • AFABP 3 4
  • ALBP 3 4
  • Epididymis Secretory Protein Li 104 3
  • HEL-S-104 3
  • AP2 3

External Ids for FABP4 Gene

Previous GeneCards Identifiers for FABP4 Gene

  • GC08M081268
  • GC08M082439
  • GC08M082113
  • GC08M082440
  • GC08M082553
  • GC08M082390
  • GC08M077880

Summaries for FABP4 Gene

Entrez Gene Summary for FABP4 Gene

  • FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP4 Gene

FABP4 (Fatty Acid Binding Protein 4, Adipocyte) is a Protein Coding gene. Diseases associated with FABP4 include coronary restenosis and cerebellar liponeurocytoma. Among its related pathways are Developmental Biology and Metabolism. GO annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP4 Gene

  • Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP4 Gene

Genomics for FABP4 Gene

Regulatory Elements for FABP4 Gene

Genomic Location for FABP4 Gene

Chromosome:
8
Start:
81,478,419 bp from pter
End:
81,483,263 bp from pter
Size:
4,845 bases
Orientation:
Minus strand

Genomic View for FABP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP4 Gene

Proteins for FABP4 Gene

  • Protein details for FABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15090-FABP4_HUMAN
    Recommended name:
    Fatty acid-binding protein, adipocyte
    Protein Accession:
    P15090
    Secondary Accessions:
    • Q6IBA1

    Protein attributes for FABP4 Gene

    Size:
    132 amino acids
    Molecular mass:
    14719 Da
    Quaternary structure:
    • Homodimer. Interacts with PPARG (By similarity). Monomer.

    Three dimensional structures from OCA and Proteopedia for FABP4 Gene

neXtProt entry for FABP4 Gene

Proteomics data for FABP4 Gene at MOPED

Post-translational modifications for FABP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP4 (FABP4)

No data available for DME Specific Peptides for FABP4 Gene

Domains & Families for FABP4 Gene

Gene Families for FABP4 Gene

Suggested Antigen Peptide Sequences for FABP4 Gene

Graphical View of Domain Structure for InterPro Entry

P15090

UniProtKB/Swiss-Prot:

FABP4_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP4: view

Function for FABP4 Gene

Molecular function for FABP4 Gene

GENATLAS Biochemistry:
fatty acid-binding protein 4,adipocyte
UniProtKB/Swiss-Prot Function:
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

Gene Ontology (GO) - Molecular Function for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005504 fatty acid binding TAS 2481498
GO:0008289 lipid binding --
genes like me logo Genes that share ontologies with FABP4: view
genes like me logo Genes that share phenotypes with FABP4: view

Animal Models for FABP4 Gene

MGI Knock Outs for FABP4:

Animal Model Products

miRNA for FABP4 Gene

miRTarBase miRNAs that target FABP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FABP4 Gene

Localization for FABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP4 Gene

Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP4 Gene COMPARTMENTS Subcellular localization image for FABP4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
peroxisome 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005811 lipid particle TAS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with FABP4: view

Pathways & Interactions for FABP4 Gene

genes like me logo Genes that share pathways with FABP4: view

PCR Array Products

SIGNOR curated interactions for FABP4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006810 transport IEA --
GO:0019433 triglyceride catabolic process TAS --
GO:0042632 cholesterol homeostasis IEA --
genes like me logo Genes that share ontologies with FABP4: view

Drugs & Compounds for FABP4 Gene

(27) Drugs for FABP4 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Pioglitazone Approved, Investigational Pharma Channel blocker 405
Rosiglitazone Approved, Investigational Pharma Channel blocker Potent PPARγ agonist 219
Sorafenib Approved, Investigational Pharma Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 653
oleic acid Experimental Pharma Activation, Activator, Carrier 0

(18) Additional Compounds for FABP4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-deoxy-delta-12,14-prostaglandin j2
87893-55-8
Acyl-CoA
carboxylate
cholesterol ester
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
genes like me logo Genes that share compounds with FABP4: view

Transcripts for FABP4 Gene

mRNA/cDNA for FABP4 Gene

Unigene Clusters for FABP4 Gene

Fatty acid binding protein 4, adipocyte:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for FABP4 Gene

GeneLoc Exon Structure for
FABP4
ECgene alternative splicing isoforms for
FABP4

Expression for FABP4 Gene

mRNA expression in normal human tissues for FABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.6), Adipose - Subcutaneous (x15.7), and Breast - Mammary Tissue (x11.3).

Protein differential expression in normal tissues from HIPED for FABP4 Gene

This gene is overexpressed in Adipocyte (35.0) and Nasopharynx (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FABP4 Gene



SOURCE GeneReport for Unigene cluster for FABP4 Gene Hs.391561

genes like me logo Genes that share expression patterns with FABP4: view

Protein tissue co-expression partners for FABP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FABP4 Gene

Orthologs for FABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FABP4 35
  • 89.39 (n)
  • 84.09 (a)
FABP4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP4 35
  • 92.68 (n)
  • 94.7 (a)
-- 36
  • 93 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fabp4 35
  • 86.11 (n)
  • 91.67 (a)
Fabp4 16
Fabp4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FABP4 35
  • 99.75 (n)
  • 100 (a)
FABP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp4 35
  • 83.84 (n)
  • 89.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 20 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves FABP4 35
  • 73.48 (n)
  • 76.52 (a)
FABP4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pmp2 35
  • 60.05 (n)
  • 59.54 (a)
worm
(Caenorhabditis elegans)
Secernentea lbp-5 35
  • 50.51 (n)
  • 51.54 (a)
Species with no ortholog for FABP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FABP4 Gene

ENSEMBL:
Gene Tree for FABP4 (if available)
TreeFam:
Gene Tree for FABP4 (if available)

Paralogs for FABP4 Gene

Paralogs for FABP4 Gene

(15) SIMAP similar genes for FABP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FABP4: view

Variants for FABP4 Gene

Sequence variations from dbSNP and Humsavar for FABP4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs14044 -- 81,478,300(+) CCCAC(C/T)GGGGG downstream-variant-500B
rs1051231 -- 81,479,452(-) CAACC(A/C)CCATA reference, missense
rs1051252 -- 81,478,858(-) CCAAG(C/G)GACGT utr-variant-3-prime
rs1054135 -- 81,478,525(-) TAGGA(A/G)ATAAC utr-variant-3-prime
rs1486005 -- 81,478,314(+) tagaa(C/T)gtacc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FABP4 Gene

Variant ID Type Subtype PubMed ID
nsv891065 CNV Loss 21882294
nsv465721 CNV Gain 19166990
nsv891066 CNV Loss 21882294

Variation tolerance for FABP4 Gene

Residual Variation Intolerance Score: 59.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP4 Gene

HapMap Linkage Disequilibrium report
FABP4
Human Gene Mutation Database (HGMD)
FABP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP4 Gene

Disorders for FABP4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FABP4 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
coronary restenosis
cerebellar liponeurocytoma
  • central neurocytoma
simpson-golabi-behmel syndrome
  • bulldog syndrome
obesity
  • obesity, association with
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association
Search FABP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP4

Genetic Association Database (GAD)
FABP4
Human Genome Epidemiology (HuGE) Navigator
FABP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP4
genes like me logo Genes that share disorders with FABP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP4 Gene

Publications for FABP4 Gene

  1. DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation. (PMID: 20070733) Park J.R. … Kang K.S. (Cell Prolif. 2010) 23 67
  2. Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4. (PMID: 20102700) Song J. … Shen Y.H. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. (PMID: 20136655) Fujitani Y. … Kawada T. (FEBS J. 2010) 23 67
  4. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. (PMID: 19842034) Hancke K. … Weiss J.M. (Breast Cancer Res. Treat. 2010) 23 67
  5. Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. (PMID: 20009357) Hsu B.G. … Wang J.H. (Circ. J. 2010) 23 67

Products for FABP4 Gene

Sources for FABP4 Gene

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