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FABP3 Gene

protein-coding   GIFtS: 70
GCID: GC01M031838

Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived...

(Previous name: fatty acid binding protein 11)
(Previous symbols: MDGI, FABP11)
  See FABP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived Growth
Inhibitor)1 2
     H-FABP2 3
FABP111 2 3     M-FABP2 3
MDGI1 2 3     O-FABP2
Fatty Acid Binding Protein 111 2     Fatty Acid-Binding Protein 3, Muscle2
Heart-Type Fatty Acid-Binding Protein2 3     Fatty Acid-Binding Protein, Heart2
Mammary-Derived Growth Inhibitor2 3     Fatty Acid-Binding Protein 33
Muscle Fatty Acid-Binding Protein2 3     

External Ids:    HGNC: 35571   Entrez Gene: 21702   Ensembl: ENSG000001217697   OMIM: 1346515   UniProtKB: P054133   

Export aliases for FABP3 gene to outside databases

Previous GC identifers: GC01M031633 GC01M030823 GC01M031264 GC01M031340 GC01M031507 GC01M029944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FABP3 Gene:
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at
least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and
are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids.
They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3
gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a
candidate tumor suppressor gene for human breast cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for FABP3 Gene:
FABP3 (fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)) is a protein-coding gene. Diseases associated with FABP3 include pulmonary embolism, and acute myocardial infarction. GO annotations related to this gene include lipid binding and long-chain fatty acid transporter activity. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413
Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their
acyl-CoA esters

Gene Wiki entry for FABP3 (Heart-type fatty acid binding protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the FABP3 gene promoter:
         AML1a   STAT5A   PPAR-alpha   CREB   PPAR-gamma1   PPAR-gamma2   Msx-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FABP3 promoter sequence
   Search Chromatin IP Primers for FABP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FABP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p33-p32

FABP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M031838:  view genomic region     (about GC identifiers)

Start:
31,838,100 bp from pter      End:
31,849,697 bp from pter
Size:
11,598 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413 (See protein sequence)
Recommended Name: Fatty acid-binding protein, heart  
Size: 133 amino acids; 14858 Da
Selected PDB 3D structures from and Proteopedia for FABP3 (see all 7):
1G5W (3D)        1HMR (3D)        1HMS (3D)        1HMT (3D)        2HMB (3D)        3RSW (3D)    
Secondary accessions: B2RAB6 Q5VV93 Q99957

Explore the universe of human proteins at neXtProt for FABP3: NX_P05413

Explore proteomics data for FABP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FABP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004093.1  
    ENSEMBL proteins: 
     ENSP00000362817   ENSP00000474078   ENSP00000473982  

    FABP3 Human Recombinant Protein Products:

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    antibodies-online peptides for FABP3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P05413

    ProtoNet protein and cluster: P05413

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    Find genes that share domains with FABP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FABPH_HUMAN, P05413
    Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their
    acyl-CoA esters

         Genatlas biochemistry entry for FABP3:
    fatty acid binding protein 3,muscle,heart

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005324long-chain fatty acid transporter activity IEA--
    GO:0005515protein binding IPI--
    GO:0008092cytoskeletal protein binding IPI17987659
    GO:0008289lipid binding ----
         
    Find genes that share ontologies with FABP3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FABP3:
     Increased cell death in HCC-19  Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fabp3):
     adipose tissue  behavior/neurological  cardiovascular system  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  muscle  vision/eye 

    Find genes that share phenotypes with FABP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FABP3: Fabp3tm1Jshr Fabp3tm1Bin

       genOway: Develop your customized and physiologically relevant rodent model for FABP3

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    miRTarBase miRNAs that target FABP3:
    hsa-mir-1 (MIRT007213)

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    4 qRT-PCR Assays for microRNAs that regulate FABP3:
    hsa-miR-3622b-3p hsa-miR-215 hsa-miR-1827 hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidFABP3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FABPH_HUMAN, P05413: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0016528sarcoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with FABP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FABP3 About    
    See pathways by source

    SuperPathContained pathways About
    1PPAR signaling pathway
    PPAR signaling pathway


    Find genes that share SuperPaths with FABP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for FABP3):
        PPAR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP3: 
              Fatty Acid Metabolism in human mouse rat
              Atherosclerosis in human mouse rat
              Fatty Liver in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FABP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FABP3 (P054131, 2, 3 ENSP000003628174) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055561, ENSP000003640944EBI-704216,EBI-703066 STRING: ENSP00000364094
    TNNI3KQ59H183, ENSP000003599284I2D: score=3 STRING: ENSP00000359928
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    VPS28Q9UK413, ENSP000003665654I2D: score=4 STRING: ENSP00000366565
    NPEPL1Q8NDH33I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0008285negative regulation of cell proliferation TAS7962070
    GO:0015909long-chain fatty acid transport ----
    GO:0032868response to insulin IEA--
    GO:0042493response to drug IEA--

    Find genes that share ontologies with FABP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FABP3 (FABPH)

    Selected HMDB Compounds for FABP3 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    3 DrugBank Compounds for FABP3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Oleic Acid-- 112-80-1carrier--17139284 17016423
    Stearic acid1-Heptadecanecarboxylic acid (see all 14)57-11-4carrier--17139284 17016423
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3carrier--1526991

    Selected Novoseek inferred chemical compound relationships for FABP3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 81.7 246 10544950 (5), 8144637 (4), 8141774 (4), 18460953 (3) (see all 99)
    creatinine 59.8 65 15173726 (3), 18455592 (2), 10905760 (2), 17376624 (2) (see all 36)
    oleic acid 37.9 2 10544950 (1), 8998570 (1)
    palmitate 31.5 2 8144637 (1), 10544950 (1)
    mibg 31.3 8 17339001 (5), 16363617 (2), 17869272 (1)
    stearic acid 30 1 9533682 (1)
    lipid 22.8 19 8144637 (3), 8262516 (1), 7811270 (1), 16210374 (1) (see all 11)
    p00001 15.5 4 15277733 (1), 11698938 (1)
    citrate 15.1 3 11959683 (1), 15746295 (1), 9893016 (1)
    phospholipid 12.2 2 8573586 (1), 8232268 (1)



    Find genes that share compounds with FABP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FABP3 gene: 
    NM_004102.3  

    Unigene Cluster for FABP3:

    Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
    Hs.657242  [show with all ESTs]
    Unigene Representative Sequence: BG336702
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373713(uc001bss.1) ENST00000497275 ENST00000498148 ENST00000482018

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    Additional mRNA sequence: 

    AK314122.1 BC007021.1 BT006727.1 CR456867.1 S67314.1 X56549.1 Y10255.1 

    11 DOTS entries:

    DT.215936  DT.100742295  DT.103125  DT.121358351  DT.121358335  DT.92422589  DT.121358282  DT.121358377 
    DT.40132392  DT.91892678  DT.445834 

    Selected AceView cDNA sequences (see all 111):

    BI757055 F31061 AI797459 F21763 AJ709193 C05513 BM668302 BG054485 
    BC007021 BE465479 AJ711720 BU680051 C04956 BF574409 BX117642 AI193560 
    F26625 F35039 AW181924 CB122004 AI367747 F34786 BG433969 C05335 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FABP3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:              -                                 
    SP2:              -           -                     
    SP3:                          -                     


    ECgene alternative splicing isoforms for FABP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FABP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTATGTGG
    FABP3 Expression
    About this image


    FABP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
    FABP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FABP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657242
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP3: 
              Fatty Acid Metabolism in human mouse rat
              Atherosclerosis in human mouse rat
              Fatty Liver in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FABP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fabp31 , 5 fatty acid binding protein 3, muscle and heart1, 5 83.46(n)1
    85.71(a)1
      4 (63.43 cM)5
    140771  NM_010174.11  NP_034304.11 
     1303085955 
    chicken
    (Gallus gallus)
    Aves FABP31 fatty acid binding protein 3, muscle and heart (mammary-derived more 76.69(n)
    78.2(a)
      419557  NM_001030889.1  NP_001026060.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fabp31 fatty acid binding protein 3, muscle and heart (mammary-derived more 65.9(n)
    64.62(a)
      548540  NM_001015823.1  NP_001015823.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fabp32 fatty acid binding protein 3, muscle and heart 73.41(n)   171478  AF448057.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fabp6
    fatty acid bindin protein
    41(a)
    1 → many
    3R(7385612-7392771)
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-66
    lbp-56
    (see all 5)
    Protein LBP-5 (lbp-5) mRNA, complete cds
    (see all 5)
    49(a)
    45(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    I(6728285-6729376) WBGene00002258
    I(6731269-6732280) WBGene00002257


    ENSEMBL Gene Tree for FABP3 (if available)
    TreeFam Gene Tree for FABP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FABP3 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  RBP12  RBP22  
    CRABP12  FABP22  PMP22  FABP72  RBP72  
    15 SIMAP similar genes for FABP3 using alignment to 4 protein entries:     FABPH_HUMAN (see all proteins):
    DKFZp547J2313    FABP7    PMP2    FABP4    FABP9    FABP5
    FABP12    FABP5P3    CRABP2    RBP5    RBP2    RBP7
    CRABP1    FABP2    RBP1

    Find genes that share paralogs with FABP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FABP3
    PGOHUM00000248387


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FABP3 (see all 208)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480914821,2
    --31838285(+) TGGAGC/GGGGGG 1 -- ut310--------
    rs1874311961,2
    --31838312(+) TGTAGA/GTACAG 1 -- ut310--------
    rs1898711141,2
    --31838421(+) CAGGCC/TGTTAT 1 -- ut310--------
    rs120646301,2
    H--31838440(+) ACTCTC/TTGACA 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 408
    rs120646761,2
    H--31838514(+) TGGCTC/TTGCTT 1 -- ut314Minor allele frequency- T:0.00NS EA 412
    rs57733531,2
    C--31838551(+) CAGTT-/A/AA  
            
    AAAAA
    2 -- ut31 trp31NA 2
    rs1832648611,2
    --31838619(+) CCTGAC/TCCCAG 1 -- ut310--------
    rs1410855361,2
    C--31838625(+) CCCAGA/GAGAAT 1 -- ut310--------
    rs2012985701,2
    C--31838767(+) AAACTA/GCAGTG 2 A V mis10--------
    rs2007511171,2
    --31838774(+) AGTGCC/TGTGGG 2 S G mis10--------

    HapMap Linkage Disequilibrium report for FABP3 (31838100 - 31849697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FABP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003353CNV Deletion20482838
    dgv46e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FABP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FABP3
    DNA2.0 Custom Variant and Variant Library Synthesis for FABP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134651    OMIM disorders: --

    11 diseases for FABP3:    
    About MalaCards
    pulmonary embolism    acute myocardial infarction    chronic thromboembolic pulmonary hypertension    intermediate charcot-marie-tooth neuropathy
    plasmodium falciparum malaria    aortic valve disease    patent ductus arteriosus    malaria
    myocardial infarction    insulin resistance    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for FABP3:
    Myocardial infarction     Coronary heart disease

    Find genes that share disorders with FABP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FABP3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acute myocardial infarction 72.2 55 1480144 (3), 16035729 (2), 16827225 (2), 15641689 (2) (see all 34)
    myocardial infarction 52.8 22 20102882 (2), 12935824 (2), 16182485 (2), 14975559 (1) (see all 16)
    ventricular dysfunction right 42.9 1 20216979 (1), 17127709 (1)
    heart failure 40.8 34 16095226 (5), 12517360 (3), 17339001 (3), 18159110 (2) (see all 16)
    cardiac death 40.2 1 18832778 (1)
    myocardial ischemia 37.7 19 15150874 (5), 14975559 (4), 19552571 (1), 12711885 (1) (see all 8)
    pulmonary embolism 34.4 17 20447541 (2), 17127709 (2), 18256058 (1), 19087222 (1) (see all 6)
    necrosis 27.3 18 18393112 (4), 16269514 (2), 11144119 (2), 16430720 (2) (see all 10)
    ischemia 18.3 15 16269514 (2), 16698556 (1), 19681456 (1), 18231825 (1) (see all 9)
    heart failure congestive 14.2 13 15704065 (5), 14594884 (3), 16880323 (1), 16198245 (1) (see all 5)

    Genetic Association Database (GAD): FABP3
    Human Genome Epidemiology (HuGE) Navigator: FABP3 (13 documents)

    Export disorders for FABP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FABP3 gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with FABP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three-dimensional structure of recombinant human muscle fatty acid- binding protein. (PubMed id 1526991)1, 2, 7, 9 Zanotti G.... Sacchettini J.C. (J. Biol. Chem. 1992)
    2. Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. (PubMed id 12872269)1, 4, 9 Shin H.D....Park K.S. (Hum. Mutat. 2003)
    3. Association between fatty acid binding protein 3 gene variants and essential hypertension in humans. (PubMed id 18437121)1, 4, 9 Ueno T....Miki T. (Am. J. Hypertens. 2008)
    4. Structural studies on human muscle fatty acid binding protein at 1.4- A resolution: binding interactions with three C18 fatty acids. (PubMed id 7922029)1, 2, 9 Young A.C.M....Sacchettini J.C. (Structure 1994)
    5. Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33. (PubMed id 8262516)1, 2, 9 Troxler R.F.... Wyandt H.E. (Hum. Genet. 1993)
    6. Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. (PubMed id 20057506)1, 4 Maekawa M....Yoshikawa T. (J. Hum. Genet. 2010)
    7. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (PubMed id 19554614)1, 4 Iwayama Y....Yoshikawa T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2170 HGNC: 3557 AceView: FABP3 Ensembl:ENSG00000121769 euGenes: HUgn2170
    ECgene: FABP3 Kegg: 2170 H-InvDB: FABP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FABP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FABP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FABP3 gene:
    Search GeneIP for patents involving FABP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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