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Aliases for FABP3 Gene

Aliases for FABP3 Gene

  • Fatty Acid Binding Protein 3, Muscle And Heart 2 3
  • Mammary-Derived Growth Inhibitor 2 3 4
  • Heart-Type Fatty Acid-Binding Protein 3 4
  • Muscle Fatty Acid-Binding Protein 3 4
  • Fatty Acid Binding Protein 11 2 3
  • FABP11 3 4
  • H-FABP 3 4
  • M-FABP 3 4
  • MDGI 3 4
  • Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived Growth Inhibitor) 2
  • Fatty Acid-Binding Protein 3, Muscle 3
  • Fatty Acid-Binding Protein, Heart 3
  • Fatty Acid-Binding Protein 3 4
  • O-FABP 3

External Ids for FABP3 Gene

Previous HGNC Symbols for FABP3 Gene

  • MDGI
  • FABP11

Previous GeneCards Identifiers for FABP3 Gene

  • GC01M031633
  • GC01M030823
  • GC01M031264
  • GC01M031340
  • GC01M031507
  • GC01M031838
  • GC01M029944

Summaries for FABP3 Gene

Entrez Gene Summary for FABP3 Gene

  • The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP3 Gene

FABP3 (Fatty Acid Binding Protein 3, Muscle And Heart) is a Protein Coding gene. Diseases associated with FABP3 include pulmonary embolism and acute myocardial infarction. Among its related pathways are PPAR signaling pathway. GO annotations related to this gene include lipid binding and long-chain fatty acid transporter activity. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP3 Gene

  • FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters

Gene Wiki entry for FABP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP3 Gene

Genomics for FABP3 Gene

Regulatory Elements for FABP3 Gene

Genomic Location for FABP3 Gene

Start:
31,365,253 bp from pter
End:
31,376,850 bp from pter
Size:
11,598 bases
Orientation:
Minus strand

Genomic View for FABP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP3 Gene

Proteins for FABP3 Gene

  • Protein details for FABP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05413-FABPH_HUMAN
    Recommended name:
    Fatty acid-binding protein, heart
    Protein Accession:
    P05413
    Secondary Accessions:
    • B2RAB6
    • Q5VV93
    • Q99957

    Protein attributes for FABP3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14858 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP3 Gene

neXtProt entry for FABP3 Gene

Proteomics data for FABP3 Gene at MOPED

Post-translational modifications for FABP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP3 (FABP3)

No data available for DME Specific Peptides for FABP3 Gene

Domains for FABP3 Gene

Gene Families for FABP3 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for FABP3 Gene

Graphical View of Domain Structure for InterPro Entry

P05413

UniProtKB/Swiss-Prot:

FABPH_HUMAN :
  • P05413
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP3: view

Function for FABP3 Gene

Molecular function for FABP3 Gene

GENATLAS Biochemistry: fatty acid binding protein 3,muscle,heart
UniProtKB/Swiss-Prot Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters

Gene Ontology (GO) - Molecular Function for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005324 long-chain fatty acid transporter activity IEA --
GO:0005515 protein binding IPI 20802519
GO:0008092 cytoskeletal protein binding IPI 17987659
GO:0008289 lipid binding --
genes like me logo Genes that share ontologies with FABP3: view
genes like me logo Genes that share phenotypes with FABP3: view

Animal Models for FABP3 Gene

MGI Knock Outs for FABP3:

Animal Model Products

CRISPR Products

miRNA for FABP3 Gene

miRTarBase miRNAs that target FABP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FABP3 Gene

Localization for FABP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP3 Gene COMPARTMENTS Subcellular localization image for FABP3 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS 23873799
GO:0016528 sarcoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FABP3: view

Pathways for FABP3 Gene

SuperPathways for FABP3 Gene

Superpath Contained pathways
1 PPAR signaling pathway
genes like me logo Genes that share pathways with FABP3: view

Pathways by source for FABP3 Gene

1 KEGG pathway for FABP3 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006810 transport --
GO:0008285 negative regulation of cell proliferation TAS 7962070
GO:0015909 long-chain fatty acid transport --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP3: view

Compounds for FABP3 Gene

(32) HMDB Compounds for FABP3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(3) Drugbank Compounds for FABP3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Oleic Acid
112-80-1 carrier
Palmitic Acid
  • 1-Hexyldecanoic Acid
57-10-3 carrier
Stearic acid
  • 1-Heptadecanecarboxylic acid
57-11-4 carrier

(22) Novoseek inferred chemical compound relationships for FABP3 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 81.7 150
creatinine 59.8 41
oleic acid 37.9 2
palmitate 31.5 2
mibg 31.3 8
genes like me logo Genes that share compounds with FABP3: view

Transcripts for FABP3 Gene

mRNA/cDNA for FABP3 Gene

Unigene Clusters for FABP3 Gene

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FABP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FABP3 Gene

GeneLoc Exon Structure for
FABP3
ECgene alternative splicing isoforms for
FABP3

Expression for FABP3 Gene

mRNA expression in normal human tissues for FABP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP3 Gene

This gene is overexpressed in Heart - Left Ventricle (24.4), Heart - Atrial Appendage (11.8), and Muscle - Skeletal (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FABP3 Gene

SOURCE GeneReport for Unigene cluster for FABP3 Gene Hs.657242

genes like me logo Genes that share expressions with FABP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FABP3 Gene

Orthologs for FABP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP3 35
  • 99.75 (n)
  • 100 (a)
FABP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP3 35
  • 88.97 (n)
  • 88.72 (a)
FABP3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP3 35
  • 92.23 (n)
  • 89.47 (a)
FABP3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp3 35
  • 83.46 (n)
  • 85.71 (a)
Fabp3 16
Fabp3 36
  • 86 (a)
OneToMany
Fabp3-ps1 36
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FABP3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FABP3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp3 35
  • 84.96 (n)
  • 89.47 (a)
chicken
(Gallus gallus)
Aves FABP3 35
  • 76.69 (n)
  • 78.2 (a)
FABP3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp3 35
  • 65.9 (n)
  • 64.62 (a)
zebrafish
(Danio rerio)
Actinopterygii fabp3 35
  • 70.48 (n)
  • 74.05 (a)
fabp3 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fabp 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 36
  • 45 (a)
ManyToMany
lbp-6 36
  • 49 (a)
ManyToMany
lbp-7 36
  • 42 (a)
ManyToMany
lbp-8 36
  • 36 (a)
ManyToMany
lbp-9 36
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
Species with no ortholog for FABP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP3 Gene

ENSEMBL:
Gene Tree for FABP3 (if available)
TreeFam:
Gene Tree for FABP3 (if available)

Paralogs for FABP3 Gene

Paralogs for FABP3 Gene

Selected SIMAP similar genes for FABP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FABP3 Gene

genes like me logo Genes that share paralogs with FABP3: view

Variants for FABP3 Gene

Sequence variations from dbSNP and Humsavar for FABP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs885847 -- 31,366,344(-) TAGTA(C/G)CCAAA intron-variant
rs951545 -- 31,371,818(-) CTCAA(C/T)GGCCT intron-variant
rs1060811 -- 31,369,802(+) AGAGC(A/T)GGGAT intron-variant
rs1137919 -- 31,369,946(+) TAAAA(A/C)TACAA intron-variant
rs2228194 - 31,369,473(-) CCTAA(A/G/T)AACAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FABP3 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
esv1003353 CNV Deletion 20482838

Relevant External Links for FABP3 Gene

HapMap Linkage Disequilibrium report
FABP3
Human Gene Mutation Database (HGMD)
FABP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP3 Gene

Disorders for FABP3 Gene

(2) University of Copenhagen DISEASES for FABP3 Gene

(29) Novoseek inferred disease relationships for FABP3 Gene

Disease -log(P) Hits PubMed IDs
acute myocardial infarction 72.2 43
myocardial infarction 52.8 19
ventricular dysfunction right 42.9 2
heart failure 40.8 29
cardiac death 40.2 1

Relevant External Links for FABP3

Genetic Association Database (GAD)
FABP3
Human Genome Epidemiology (HuGE) Navigator
FABP3
genes like me logo Genes that share disorders with FABP3: view

No data available for UniProtKB/Swiss-Prot for FABP3 Gene

Publications for FABP3 Gene

  1. Three-dimensional structure of recombinant human muscle fatty acid- binding protein. (PMID: 1526991) Zanotti G. … Sacchettini J.C. (J. Biol. Chem. 1992) 3 4 23 25
  2. Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33. (PMID: 8262516) Troxler R.F. … Wyandt H.E. (Hum. Genet. 1993) 3 4 23
  3. Structural studies on human muscle fatty acid binding protein at 1.4- A resolution: binding interactions with three C18 fatty acids. (PMID: 7922029) Young A.C.M. … Sacchettini J.C. (Structure 1994) 3 4 23
  4. Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. (PMID: 12872269) Shin H.D. … Park K.S. (Hum. Mutat. 2003) 3 23 48
  5. Association between fatty acid binding protein 3 gene variants and essential hypertension in humans. (PMID: 18437121) Ueno T. … Miki T. (Am. J. Hypertens. 2008) 3 23 48

Products for FABP3 Gene

Sources for FABP3 Gene

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