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Aliases for FABP3 Gene

Aliases for FABP3 Gene

  • Fatty Acid Binding Protein 3 2 3 5
  • Mammary-Derived Growth Inhibitor 2 3 4
  • Fatty Acid Binding Protein 3, Muscle And Heart 2 3
  • Heart-Type Fatty Acid-Binding Protein 3 4
  • Muscle Fatty Acid-Binding Protein 3 4
  • Fatty Acid Binding Protein 11 2 3
  • FABP11 3 4
  • H-FABP 3 4
  • M-FABP 3 4
  • MDGI 3 4
  • Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived Growth Inhibitor) 2
  • Fatty Acid-Binding Protein, Heart 3
  • Fatty Acid-Binding Protein 3 4
  • O-FABP 3

External Ids for FABP3 Gene

Previous HGNC Symbols for FABP3 Gene

  • MDGI
  • FABP11

Previous GeneCards Identifiers for FABP3 Gene

  • GC01M031633
  • GC01M030823
  • GC01M031264
  • GC01M031340
  • GC01M031507
  • GC01M031838
  • GC01M029944

Summaries for FABP3 Gene

Entrez Gene Summary for FABP3 Gene

  • The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for FABP3 Gene

FABP3 (Fatty Acid Binding Protein 3) is a Protein Coding gene. Diseases associated with FABP3 include Acute Myocardial Infarction and Pulmonary Embolism. Among its related pathways are Metabolism and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transporter activity and cytoskeletal protein binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP3 Gene

  • FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Gene Wiki entry for FABP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP3 Gene

Genomics for FABP3 Gene

Regulatory Elements for FABP3 Gene

Enhancers for FABP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F031420 1.2 Ensembl ENCODE 11.3 -45.9 -45859 4.0 HDGF ATF1 PKNOX1 WRNIP1 ARID4B ZNF48 GLIS2 ZNF143 FOS DEK SERINC2 FABP3 LOC105378626 TINAGL1 SNRNP40 LOC105378625
GH01F031470 1.2 ENCODE 10.7 -95.2 -95244 2.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 LOC105378626 SERINC2 SNRNP40 ENSG00000224066 RNU6-40P TSSK3 FABP3 TINAGL1 HDAC1 ENSG00000229447
GH01F031396 1 Ensembl ENCODE 11.7 -20.6 -20635 2.1 CTCF MAX BMI1 RAD21 RARA ZKSCAN1 ZNF121 ADNP SMC3 FOS SERINC2 FABP3 ENSG00000229044 RNU6-40P TINAGL1 LOC105378626 COL16A1 LOC105378623
GH01F031305 1 Ensembl ENCODE 10.8 +70.6 70550 2.1 BCOR SMARCA5 CTCF CBX3 JUN BHLHE40 CEBPB ZMYM3 NFXL1 EP300 SERINC2 ENSG00000229044 FABP3 SNRNP40 GC01P031311 ZCCHC17
GH01F031400 0.8 Ensembl 11.7 -23.8 -23751 0.4 BCOR TBL1XR1 NR2F6 ZSCAN29 TRIM24 ZNF639 SMARCE1 MTA2 BHLHE40 CEBPB SERINC2 FABP3 LOC105378626 TINAGL1 LOC105378623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FABP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FABP3 Gene

Chromosome:
1
Start:
31,360,418 bp from pter
End:
31,376,850 bp from pter
Size:
16,433 bases
Orientation:
Minus strand

Genomic View for FABP3 Gene

Genes around FABP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP3 Gene

Proteins for FABP3 Gene

  • Protein details for FABP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05413-FABPH_HUMAN
    Recommended name:
    Fatty acid-binding protein, heart
    Protein Accession:
    P05413
    Secondary Accessions:
    • B2RAB6
    • Q5VV93
    • Q99957

    Protein attributes for FABP3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14858 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP3 Gene

neXtProt entry for FABP3 Gene

Post-translational modifications for FABP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP3 Gene

No data available for DME Specific Peptides for FABP3 Gene

Domains & Families for FABP3 Gene

Gene Families for FABP3 Gene

Suggested Antigen Peptide Sequences for FABP3 Gene

Graphical View of Domain Structure for InterPro Entry

P05413

UniProtKB/Swiss-Prot:

FABPH_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP3: view

Function for FABP3 Gene

Molecular function for FABP3 Gene

GENATLAS Biochemistry:
fatty acid binding protein 3,muscle,heart
UniProtKB/Swiss-Prot Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Gene Ontology (GO) - Molecular Function for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005324 long-chain fatty acid transporter activity IEA --
GO:0005504 fatty acid binding IEA --
GO:0005515 protein binding IPI 20802519
GO:0008092 cytoskeletal protein binding IPI 17987659
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP3: view
genes like me logo Genes that share phenotypes with FABP3: view

Animal Models for FABP3 Gene

MGI Knock Outs for FABP3:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP3 Gene

Localization for FABP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP3 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 2
peroxisome 2
golgi apparatus 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,TAS 23873799
GO:0016528 sarcoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FABP3: view

Pathways & Interactions for FABP3 Gene

genes like me logo Genes that share pathways with FABP3: view

Pathways by source for FABP3 Gene

Gene Ontology (GO) - Biological Process for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006810 transport IEA --
GO:0008285 negative regulation of cell proliferation TAS 7962070
GO:0015909 long-chain fatty acid transport IEA --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP3: view

No data available for SIGNOR curated interactions for FABP3 Gene

Drugs & Compounds for FABP3 Gene

(11) Drugs for FABP3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist, Carrier 0
Stearic acid Experimental Pharma Carrier 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Carrier 22
Propionyl-CoA Experimental Pharma 0

(44) Additional Compounds for FABP3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with FABP3: view

Transcripts for FABP3 Gene

Unigene Clusters for FABP3 Gene

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FABP3 Gene

GeneLoc Exon Structure for
FABP3
ECgene alternative splicing isoforms for
FABP3

Expression for FABP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FABP3 Gene

mRNA differential expression in normal tissues according to GTEx for FABP3 Gene

This gene is overexpressed in Heart - Left Ventricle (x24.4), Heart - Atrial Appendage (x11.8), and Muscle - Skeletal (x7.2).

Protein differential expression in normal tissues from HIPED for FABP3 Gene

This gene is overexpressed in Milk (39.6) and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FABP3 Gene



Protein tissue co-expression partners for FABP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FABP3 Gene:

FABP3

SOURCE GeneReport for Unigene cluster for FABP3 Gene:

Hs.657242
genes like me logo Genes that share expression patterns with FABP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FABP3 Gene

Orthologs for FABP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP3 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia FABP3 34 35
  • 92.23 (n)
cow
(Bos Taurus)
Mammalia FABP3 34 35
  • 88.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FABP3 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp3 34
  • 84.96 (n)
mouse
(Mus musculus)
Mammalia Fabp3-ps1 35
  • 84 (a)
OneToMany
Fabp3 34 16 35
  • 83.46 (n)
oppossum
(Monodelphis domestica)
Mammalia FABP3 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves FABP3 34 35
  • 76.69 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp3 34
  • 65.9 (n)
zebrafish
(Danio rerio)
Actinopterygii fabp3 34 35
  • 70.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta fabp 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-6 35
  • 49 (a)
ManyToMany
lbp-5 35
  • 45 (a)
ManyToMany
lbp-7 35
  • 42 (a)
ManyToMany
lbp-9 35
  • 37 (a)
ManyToMany
lbp-8 35
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
Species where no ortholog for FABP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP3 Gene

ENSEMBL:
Gene Tree for FABP3 (if available)
TreeFam:
Gene Tree for FABP3 (if available)

Paralogs for FABP3 Gene

Paralogs for FABP3 Gene

(15) SIMAP similar genes for FABP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FABP3 Gene

genes like me logo Genes that share paralogs with FABP3: view

Variants for FABP3 Gene

Sequence variations from dbSNP and Humsavar for FABP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs431905487 untested 31,369,360(-) GTGGG(-/G)AATGG intron-variant
rs431905488 untested 31,365,958(-) ATCTC(A/G)CTCTG intron-variant, downstream-variant-500B
rs483352865 untested 31,365,893(-) GAAAG(-/A)GGCAT intron-variant, downstream-variant-500B, reference, frameshift-variant
rs483352874 untested 31,369,368(-) GAAAC(-/AG)GGGTG intron-variant
rs483352875 untested 31,365,952(-) ACTCT(-/GT)CTTTC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FABP3 Gene

Variant ID Type Subtype PubMed ID
esv1003353 CNV deletion 20482838
esv2758930 CNV loss 17122850
nsv1118432 CNV duplication 24896259

Variation tolerance for FABP3 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP3 Gene

Human Gene Mutation Database (HGMD)
FABP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP3 Gene

Disorders for FABP3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for FABP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myocardial infarction
pulmonary embolism
  • pulmonary artery embolism
intermediate charcot-marie-tooth neuropathy
cerebral creatine deficiency syndrome 1
  • creatine transporter deficiency
methylmalonic aciduria and homocystinuria, cblc type
  • methylmalonic aciduria and homocystinuria type cblc
- elite association - COSMIC cancer census association via MalaCards
Search FABP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP3

Genetic Association Database (GAD)
FABP3
Human Genome Epidemiology (HuGE) Navigator
FABP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP3
genes like me logo Genes that share disorders with FABP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP3 Gene

Publications for FABP3 Gene

  1. Association between fatty acid binding protein 3 gene variants and essential hypertension in humans. (PMID: 18437121) Ueno T. … Miki T. (Am. J. Hypertens. 2008) 3 22 46 64
  2. Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. (PMID: 12872269) Shin H.D. … Park K.S. (Hum. Mutat. 2003) 3 22 46 64
  3. Structural studies on human muscle fatty acid binding protein at 1.4- A resolution: binding interactions with three C18 fatty acids. (PMID: 7922029) Young A.C.M. … Sacchettini J.C. (Structure 1994) 3 4 22 64
  4. Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33. (PMID: 8262516) Troxler R.F. … Wyandt H.E. (Hum. Genet. 1993) 3 4 22 64
  5. Three-dimensional structure of recombinant human muscle fatty acid- binding protein. (PMID: 1526991) Zanotti G. … Sacchettini J.C. (J. Biol. Chem. 1992) 3 4 22 64

Products for FABP3 Gene

Sources for FABP3 Gene

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