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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FABP3 Gene

protein-coding GIFtS: 69
GCID: GC01M031838

fatty acid binding protein 3, muscle and heart (mammary-derived...

(Previous name: fatty acid binding protein 11 )
(Previous symbols: MDGI, FABP11)

Explore 53 diseases affiliated with
FABP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived Growth Inhibitor)¹ ²		Mammary-Derived Growth Inhibitor² ³
FABP11¹ ² ³		Muscle Fatty Acid-Binding Protein² ³
H-FABP¹ ² ³		M-FABP² ³
MDGI¹ ² ³		Fatty Acid-Binding Protein 3, Muscle²
O-FABP¹ ²		Fatty Acid-Binding Protein, Heart²
Fatty Acid Binding Protein 11¹ ²		Fatty Acid-Binding Protein 3³
Heart-Type Fatty Acid-Binding Protein² ³

External Ids:	HGNC: 3557¹	Entrez Gene: 2170²	Ensembl: ENSG00000121769⁷	OMIM: 134651⁵	UniProtKB: P05413³

Export aliases for FABP3 gene to outside databases

Previous GC identifers: GC01M031633 GC01M030823 GC01M031264 GC01M031340 GC01M031507 GC01M029944

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FABP3:

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least

three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought

to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be

responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons

and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for

human breast cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413

Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA

esters

Gene Wiki entry for FABP3 (Heart-type fatty acid binding protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FABP3 gene promoter:
AML1a STAT5A PPAR-alpha CREB PPAR-gamma1 PPAR-gamma2 Msx-1 Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FABP3 promoter sequence

Search SABiosciences Chromatin IP Primers for FABP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p33-p32

FABP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M031838: view genomic region (about GC identifiers)

Start:	31,838,100 bp from pter	End:	31,849,697 bp from pter
Size:	11,598 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413 (See protein sequence)

Recommended Name: Fatty acid-binding protein, heart

Size: 133 amino acids; 14858 Da

Subcellular location: Cytoplasm

6 PDB 3D structures from and Proteopedia for FABP3:

1G5W (3D)

1HMR (3D)

1HMS (3D)

1HMT (3D)

2HMB (3D)

3RSW (3D)

Secondary accessions: B2RAB6 Q5VV93 Q99957

Explore the universe of human proteins at neXtProt for FABP3: NX_P05413

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05413

FABP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004093.1

ENSEMBL proteins:

ENSP00000362817

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	Uscn Proteins for FABP3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	IEA	--
GO:0016528	sarcoplasm	IEA	--

FABP3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FABP3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FABP3 for domains About GeneDecksing

4 InterPro domains/families:

IPR012674 Calycin

IPR011038 Calycin-like

IPR000463 Fatty_acid-bd

IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry P05413

ProtoNet protein and cluster: P05413

1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413

Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior

Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FABPH_HUMAN, P05413

Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA

esters

Genatlas biochemistry entry for FABP3:

fatty acid binding protein 3,muscle,heart

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		hsa-miR-3622b-3p hsa-miR-215 hsa-miR-1827 hsa-miR-192
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005324	long-chain fatty acid transporter activity	IEA	--
GO:0005504	fatty acid binding	--	--
GO:0005515	protein binding	IPI	--
GO:0008092	cytoskeletal protein binding	IPI	17987659
GO:0008289	lipid binding	TAS	3421901

FABP3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for FABP3:

Increased cell death in HCC-19

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for FABP3: Fabp3^tm1Jshr Fabp3^tm1Bin
9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Fabp3):

adipose tissue	behavior/neurological	cardiovascular system	homeostasis/metabolism	integument
liver/biliary system	mortality/aging	muscle	vision/eye

FABP3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PPAR signaling pathway

PPAR signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for FABP3):

PPAR signaling pathway

FABP3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FABP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/13 Interacting proteins for FABP3 (P05413^{1, 2, 3} ENSP00000362817⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNNI3K	Q59H18³, ENSP00000359928⁴	I2D: score=3 STRING: ENSP00000359928
FPGT-TNNI3K	Q59H18³	I2D: score=3
ITGB1	P05556¹, ENSP00000364094⁴	EBI-704216,EBI-4289597 STRING: ENSP00000364094
PLK1	P53350³, ENSP00000300093⁴	I2D: score=2 STRING: ENSP00000300093
VPS28	Q9UK41³, ENSP00000366565⁴	I2D: score=4 STRING: ENSP00000366565

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006631	fatty acid metabolic process	IEA	--
GO:0006656	phosphatidylcholine biosynthetic process	--	--
GO:0008285	negative regulation of cell proliferation	TAS	7962070
GO:0015909	long-chain fatty acid transport	--	--
GO:0032868	response to insulin stimulus	IEA	--

FABP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FABP3 for compounds About GeneDecksing

EMD Millipore small molecules for FABP3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FABP3

10/32 HMDB Compounds for FABP3 (see all 32) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

3 DrugBank Compounds for FABP3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Oleic Acid	--	112-80-1	carrier	--	17139284 17016423
Stearic acid	1-Heptadecanecarboxylic acid (see all 14)	57-11-4	carrier	--	17139284 17016423
Palmitic Acid	1-Hexyldecanoic Acid (see all 11)	57-10-3	carrier	--	1526991

10/22 Novoseek chemical compound relationships for FABP3 gene (see all 22) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid	81.7	246	10544950 (5), 8144637 (4), 8141774 (4), 18460953 (3) (see all 99)
creatinine	59.8	65	15173726 (3), 18455592 (2), 10905760 (2), 17376624 (2) (see all 36)
oleic acid	37.9	2	10544950 (1), 8998570 (1)
palmitate	31.5	2	8144637 (1), 10544950 (1)
mibg	31.3	8	17339001 (5), 16363617 (2), 17869272 (1)
stearic acid	30	1	9533682 (1)
lipid	22.8	19	8144637 (3), 8262516 (1), 7811270 (1), 16210374 (1) (see all 11)
p00001	15.5	4	15277733 (1), 11698938 (1)
citrate	15.1	3	11959683 (1), 15746295 (1), 9893016 (1)
phospholipid	12.2	2	8573586 (1), 8232268 (1)

Search CenterWatch for drugs/clinical trials and news about FABP3 / FABPH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FABP3 gene:

NM_004102.3

Unigene Cluster for FABP3:

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)

Hs.657242 [show with all ESTs]

Unigene Representative Sequence: BG336702

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373713(uc001bss.1) ENST00000497275 ENST00000498148 ENST00000482018

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Additional cDNA sequence:

AK314122.1 BC007021.1 BT006727.1 CR456867.1 S67314.1 X56549.1 Y10255.1

11 DOTS entries:

DT.215936 DT.100742295 DT.103125 DT.121358351 DT.121358335 DT.92422589 DT.121358282 DT.121358377

DT.40132392 DT.91892678 DT.445834

24/111 AceView cDNA sequences (see all 111):

AI797459 C05513 BC007021 BU680051 C04956 F31061 F21763 BG054485

BE465479 AJ709193 BM668302 AJ711720 BI757055 Z32785 N90285 AI367747

AI192911 BG433969 AJ706659 F26625 AW971635 BF574409 F34786 BT006727

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FABP3 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b
SP1:					-
SP2:					-				-
SP3:									-

ECgene alternative splicing isoforms for FABP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FABP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTATGTGG

About this image

FABP3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Adipose

Interscapular Brown Adipose Depot

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

See FABP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FABP3

SOURCE GeneReport for Unigene cluster: Hs.657242

SABiosciences Expression via Pathway-Focused PCR Arrays including FABP3:

Fatty Acid Metabolism in human mouse rat

Atherosclerosis in human mouse rat

Fatty Liver in human mouse rat

PPAR Targets in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for FABP3 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FABP3¹	fatty acid binding protein 3, muscle and heart (mammary-derived more	77.1(n) 79.39(a)		419557 NM_001030889.1 NP_001026060.1
zebrafish (Danio rerio)	Actinopterygii	fabp3²	fatty acid binding protein 3, muscle and heart	73.41(n)		171478 AF448057.1
fruit fly (Drosophila melanogaster)	Insecta	fabp⁶	fatty acid bindin protein	40(a)	possible ortholog	3R(7385612-7392771)
worm (Caenorhabditis elegans)	Secernentea	lbp-6⁶ lbp-5⁶ (see all 5)	Fatty acid-binding protein homolog 5 (see all 5)	47(a) 43(a) (see all 5)	many ↔ many many ↔ many (see all 5)	I(6728286-6729379) I(6731270-6732281)

ENSEMBL Gene Tree for FABP3 (if available)
TreeFam Gene Tree for FABP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FABP3 gene

FABP5² RBP5² FABP9² CRABP2² FABP12² FABP4² RBP1² CRABP1²

RBP2² FABP2² PMP2² FABP7² RBP7²

15 SIMAP similar genes for FABP3 using alignment to 2 protein entries: FABPH_HUMAN (see all proteins):

DKFZp547J2313 FABP7 PMP2 FABP9 FABP4 FABP12

FABP5 FABP5P3 CRABP2 RBP2 RBP5 CRABP1

FABP2 RBP1 RBP7

FABP3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FABP3
PGOHUM00000248387

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17495262^1,2	C,F,H,	--	29944408(+)	`CTTAAC/G/TTTGTG`	2	--	ut3¹		26		NA NS EA WA CSA	2463
rs41263944^1,2	C,F,	--	29944459(+)	`AAGATC/AATTGT`	1	--	ut3¹		6		NA WA CSA	246
rs12239180^1,2	H,	--	29944605(+)	`ACTTAC/TAGACT`	1	--	ds500¹		4		NS EA	420
rs61780773^1,2	C,F,	--	29945029(+)	`NNNNTC/TACTGA`	1	--	ds500¹		6		WA NA CSA	244
rs191338133^1,2		--	31837877(+)	`TAATAA/TGTTAC`	1	--	ds500¹		0	--	--	--	--
rs16834408^1,2	C,F,H,	--	31837942(+)	`TCACTG/ACCTTC`	1	--	ds500¹		22		NA NS EA WA CSA	2483
rs144380026^1,2	C,	--	31838018(+)	`TAGAG-/AAGCAG`	1	--	ds500¹		0	--	--	--	--
rs182831662^1,2		--	31838175(+)	`CAGAGA/TACAGC`	1	--	ut3¹		0	--	--	--	--
rs148091482^1,2		--	31838285(+)	`TGGAGC/GGGGGG`	1	--	ut3¹		0	--	--	--	--
rs187431196^1,2		--	31838312(+)	`TGTAGA/GTACAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FABP3 (31838100 - 31849697 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FABP3
2 CNVs: 2304 3287
Human Gene Mutation Database (HGMD): FABP3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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FABP3 for disorders           About GeneDecksing

OMIM gene information: 134651    OMIM disorders: --

20/53 diseases for FABP3 (see all 53):    About MalaCards

charcot-marie-tooth neuropathy breast cancer plasmodium falciparum malaria hepatitis

myocardial infarction acute myocardial infarction pulmonary embolism type 2 diabetes mellitus

congestive heart failure dilated cardiomyopathy sleep apnea insulin resistance

anorexia nervosa diabetes mellitus hypertrophic cardiomyopathy neurodegenerative disease

acute myeloid leukemia apnea acute myocarditis myeloid leukemia

2 diseases from the University of Copenhagen DISEASES database for FABP3:

Myocardial infarction Coronary heart disease

10/29 Novoseek disease relationships for FABP3 gene (see all 29) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acute myocardial infarction	72.2	55	1480144 (3), 16035729 (2), 16827225 (2), 15641689 (2) (see all 34)
myocardial infarction	52.8	22	20102882 (2), 12935824 (2), 16182485 (2), 14975559 (1) (see all 16)
ventricular dysfunction right	42.9	1	20216979 (1), 17127709 (1)
heart failure	40.8	34	16095226 (5), 12517360 (3), 17339001 (3), 18159110 (2) (see all 16)
cardiac death	40.2	1	18832778 (1)
myocardial ischemia	37.7	19	15150874 (5), 14975559 (4), 19552571 (1), 12711885 (1) (see all 8)
pulmonary embolism	34.4	17	20447541 (2), 17127709 (2), 18256058 (1), 19087222 (1) (see all 6)
necrosis	27.3	18	18393112 (4), 16269514 (2), 11144119 (2), 16430720 (2) (see all 10)
ischemia	18.3	15	16269514 (2), 16698556 (1), 19681456 (1), 18231825 (1) (see all 9)
heart failure congestive	14.2	13	15704065 (5), 14594884 (3), 16880323 (1), 16198245 (1) (see all 5)

Genetic Association Database (GAD): FABP3
Human Genome Epidemiology (HuGE) Navigator: FABP3 (13 documents)

Export disorders for FABP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FABP3 gene, integrated from 9 sources (see all 261):
(articles sorted by number of sources associating them with FABP3)

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Three-dimensional structure of recombinant human muscle fatty acid- binding protein. (PubMed id 1526991)^{1, 2, 7, 9} Zanotti G.... Sacchettini J.C. (1992)
Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. (PubMed id 12872269)^{1, 4, 9} Shin H.D....Park K.S. (2003)
Structural studies on human muscle fatty acid binding protein at 1.4- A resolution: binding interactions with three C18 fatty acids. (PubMed id 7922029)^{1, 2, 9} Young A.C.M....Sacchettini J.C. (1994)
Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33. (PubMed id 8262516)^{1, 2, 9} Troxler R.F.... Wyandt H.E. (1993)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors. (PubMed id 8661024)^{1, 3} Phelan C.M....Narod S.A. (1996)
The major protein expression profile and two-dimensional protein database of human heart. (PubMed id 7498159)^{1, 2} Kovalyov L.I.... Musalyamov A.K. (1995)
Cloning of the cDNA encoding human skeletal-muscle fatty-acid-binding protein, its peptide sequence and chromosomal localization. (PubMed id 1710107)^{1, 2} Peeter R.A.... Geurts van Kessel A. (1991)
Revision of the amino acid sequence of human heart fatty acid-binding protein. (PubMed id 2266954)^{1, 2} Boerchers T....Knudsen J. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2170	HGNC: 3557	AceView: FABP3	Ensembl:ENSG00000121769	euGenes: HUgn2170
ECgene: FABP3	Kegg: 2170	H-InvDB: FABP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FABP3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FABP3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FABP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FABP3 gene:
Search GeneIP for patents involving FABP3

GeneCards and IP:
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FABP3 Gene

fatty acid binding protein 3, muscle and heart (mammary-derived...

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