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Aliases for FABP3 Gene

Aliases for FABP3 Gene

  • Fatty Acid Binding Protein 3 2 3
  • Fatty Acid Binding Protein 3, Muscle And Heart 2 3 5
  • Mammary-Derived Growth Inhibitor 2 3 4
  • Heart-Type Fatty Acid-Binding Protein 3 4
  • Muscle Fatty Acid-Binding Protein 3 4
  • Fatty Acid Binding Protein 11 2 3
  • FABP11 3 4
  • H-FABP 3 4
  • M-FABP 3 4
  • MDGI 3 4
  • Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived Growth Inhibitor) 2
  • Fatty Acid-Binding Protein 3, Muscle 3
  • Fatty Acid-Binding Protein 3 4
  • O-FABP 3

External Ids for FABP3 Gene

Previous HGNC Symbols for FABP3 Gene

  • MDGI
  • FABP11

Previous GeneCards Identifiers for FABP3 Gene

  • GC01M031633
  • GC01M030823
  • GC01M031264
  • GC01M031340
  • GC01M031507
  • GC01M031838
  • GC01M029944

Summaries for FABP3 Gene

Entrez Gene Summary for FABP3 Gene

  • The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for FABP3 Gene

FABP3 (Fatty Acid Binding Protein 3) is a Protein Coding gene. Diseases associated with FABP3 include Acute Myocardial Infarction and Pulmonary Embolism. Among its related pathways are Glucose / Energy Metabolism and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transporter activity and cytoskeletal protein binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP3 Gene

  • FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Gene Wiki entry for FABP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP3 Gene

Genomics for FABP3 Gene

Regulatory Elements for FABP3 Gene

Enhancers for FABP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FABP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FABP3 Gene

Chromosome:
1
Start:
31,360,418 bp from pter
End:
31,376,850 bp from pter
Size:
16,433 bases
Orientation:
Minus strand

Genomic View for FABP3 Gene

Genes around FABP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP3 Gene

Proteins for FABP3 Gene

  • Protein details for FABP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05413-FABPH_HUMAN
    Recommended name:
    Fatty acid-binding protein, heart
    Protein Accession:
    P05413
    Secondary Accessions:
    • B2RAB6
    • Q5VV93
    • Q99957

    Protein attributes for FABP3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14858 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP3 Gene

neXtProt entry for FABP3 Gene

Proteomics data for FABP3 Gene at MOPED

Post-translational modifications for FABP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP3 (FABP3)

No data available for DME Specific Peptides for FABP3 Gene

Domains & Families for FABP3 Gene

Gene Families for FABP3 Gene

Suggested Antigen Peptide Sequences for FABP3 Gene

Graphical View of Domain Structure for InterPro Entry

P05413

UniProtKB/Swiss-Prot:

FABPH_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP3: view

Function for FABP3 Gene

Molecular function for FABP3 Gene

GENATLAS Biochemistry:
fatty acid binding protein 3,muscle,heart
UniProtKB/Swiss-Prot Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Gene Ontology (GO) - Molecular Function for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20802519
GO:0008092 cytoskeletal protein binding IPI 17987659
GO:0050543 icosatetraenoic acid binding IEA --
GO:0070538 oleic acid binding IDA 3421901
genes like me logo Genes that share ontologies with FABP3: view
genes like me logo Genes that share phenotypes with FABP3: view

Animal Models for FABP3 Gene

MGI Knock Outs for FABP3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP3 Gene

Localization for FABP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP3 Gene COMPARTMENTS Subcellular localization image for FABP3 gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 2
golgi apparatus 2
mitochondrion 2
peroxisome 2
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FABP3: view

Pathways & Interactions for FABP3 Gene

genes like me logo Genes that share pathways with FABP3: view

Pathways by source for FABP3 Gene

Gene Ontology (GO) - Biological Process for FABP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006810 transport IEA --
GO:0015909 long-chain fatty acid transport IEA --
GO:0019433 triglyceride catabolic process TAS --
GO:0042632 cholesterol homeostasis ISS --
genes like me logo Genes that share ontologies with FABP3: view

No data available for SIGNOR curated interactions for FABP3 Gene

Drugs & Compounds for FABP3 Gene

(10) Drugs for FABP3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Experimental Pharma Full agonist, Agonist, Carrier 0
Stearic acid Experimental Pharma Carrier 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Carrier 22
Propionyl-CoA Experimental Pharma 0

(45) Additional Compounds for FABP3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with FABP3: view

Transcripts for FABP3 Gene

Unigene Clusters for FABP3 Gene

Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FABP3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FABP3 Gene

GeneLoc Exon Structure for
FABP3
ECgene alternative splicing isoforms for
FABP3

Expression for FABP3 Gene

mRNA expression in normal human tissues for FABP3 Gene

mRNA differential expression in normal tissues according to GTEx for FABP3 Gene

This gene is overexpressed in Heart - Left Ventricle (x24.4), Heart - Atrial Appendage (x11.8), and Muscle - Skeletal (x7.2).

Protein differential expression in normal tissues from HIPED for FABP3 Gene

This gene is overexpressed in Milk (39.6) and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FABP3 Gene



SOURCE GeneReport for Unigene cluster for FABP3 Gene Hs.657242

genes like me logo Genes that share expression patterns with FABP3: view

Protein tissue co-expression partners for FABP3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FABP3 Gene

Orthologs for FABP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FABP3 35
  • 88.97 (n)
  • 88.72 (a)
FABP3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP3 35
  • 92.23 (n)
  • 89.47 (a)
FABP3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp3 35
  • 83.46 (n)
  • 85.71 (a)
Fabp3 16
Fabp3 36
  • 86 (a)
OneToMany
Fabp3-ps1 36
  • 84 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FABP3 35
  • 99.75 (n)
  • 100 (a)
FABP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp3 35
  • 84.96 (n)
  • 89.47 (a)
oppossum
(Monodelphis domestica)
Mammalia FABP3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FABP3 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves FABP3 35
  • 76.69 (n)
  • 78.2 (a)
FABP3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp3 35
  • 65.9 (n)
  • 64.62 (a)
zebrafish
(Danio rerio)
Actinopterygii fabp3 35
  • 70.48 (n)
  • 74.05 (a)
fabp3 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fabp 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 36
  • 45 (a)
ManyToMany
lbp-6 36
  • 49 (a)
ManyToMany
lbp-7 36
  • 42 (a)
ManyToMany
lbp-8 36
  • 36 (a)
ManyToMany
lbp-9 36
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
Species with no ortholog for FABP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP3 Gene

ENSEMBL:
Gene Tree for FABP3 (if available)
TreeFam:
Gene Tree for FABP3 (if available)

Paralogs for FABP3 Gene

Paralogs for FABP3 Gene

(15) SIMAP similar genes for FABP3 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FABP3 Gene

genes like me logo Genes that share paralogs with FABP3: view

Variants for FABP3 Gene

Sequence variations from dbSNP and Humsavar for FABP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2228194 - 31,369,473(-) CCTAA(A/G/T)AACAC reference, missense
rs885847 -- 31,366,344(-) TAGTA(C/G)CCAAA intron-variant
rs1137919 -- 31,369,946(+) TAAAA(A/C)TACAA intron-variant
rs951545 -- 31,371,818(-) CTCAA(C/T)GGCCT intron-variant
rs1060811 -- 31,369,802(+) AGAGC(A/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FABP3 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
esv1003353 CNV Deletion 20482838

Variation tolerance for FABP3 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP3 Gene

Human Gene Mutation Database (HGMD)
FABP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP3 Gene

Disorders for FABP3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for FABP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myocardial infarction
pulmonary embolism
  • pulmonary artery embolism
intermediate charcot-marie-tooth neuropathy
plasmodium falciparum malaria
  • falciparum malaria
creatine transporter deficiency
  • cerebral creatine deficiency syndrome 1
- elite association - COSMIC cancer census association via MalaCards
Search FABP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP3

Genetic Association Database (GAD)
FABP3
Human Genome Epidemiology (HuGE) Navigator
FABP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP3
genes like me logo Genes that share disorders with FABP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP3 Gene

Publications for FABP3 Gene

  1. Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. (PMID: 12872269) Shin H.D. … Park K.S. (Hum. Mutat. 2003) 3 23 48 67
  2. Three-dimensional structure of recombinant human muscle fatty acid- binding protein. (PMID: 1526991) Zanotti G. … Sacchettini J.C. (J. Biol. Chem. 1992) 3 23 25
  3. A one-step immunotest for rapid detection of heart-type fatty acid-binding protein in patients with acute coronary syndromes. (PMID: 20391015) Xie P.Y. … Renneberg R. (J Immunoassay Immunochem 2010) 3 23
  4. Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. (PMID: 19576209) Yan G.T. … Wang L.H. (Eur. J. Pharmacol. 2009) 3 23
  5. Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure. (PMID: 18159110) Niizeki T. … Kubota I. (Circ. J. 2008) 3 23

Products for FABP3 Gene

Sources for FABP3 Gene

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