Aliases for FABP2 Gene
External Ids for FABP2 Gene
Previous GeneCards Identifiers for FABP2 Gene
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
GeneCards Summary for FABP2 Gene
FABP2 (Fatty Acid Binding Protein 2, Intestinal) is a Protein Coding gene. Diseases associated with FABP2 include ileitis and hyperlipidemia, familial combined. Among its related pathways are Fat digestion and absorption and PPAR signaling pathway. GO annotations related to this gene include fatty acid binding and long-chain fatty acid transporter activity. An important paralog of this gene is FABP7.
UniProtKB/Swiss-Prot for FABP2 Gene
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor