Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FABP2 Gene

Aliases for FABP2 Gene

  • Fatty Acid Binding Protein 2, Intestinal 2 3
  • Intestinal-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 2 3 4
  • I-FABP 3 4
  • FABPI 3 4
  • Fatty Acid-Binding Protein, Intestinal 3

External Ids for FABP2 Gene

Summaries for FABP2 Gene

Entrez Gene Summary for FABP2 Gene

  • The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP2 Gene

FABP2 (Fatty Acid Binding Protein 2, Intestinal) is a Protein Coding gene. Diseases associated with FABP2 include ileitis and hyperlipidemia, familial combined. Among its related pathways are Fat digestion and absorption and PPAR signaling pathway. GO annotations related to this gene include fatty acid binding and long-chain fatty acid transporter activity. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP2 Gene

  • FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor

Gene Wiki entry for FABP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP2 Gene

Genomics for FABP2 Gene

Genomic Location for FABP2 Gene

Start:
119,317,250 bp from pter
End:
119,322,390 bp from pter
Size:
5,141 bases
Orientation:
Minus strand

Genomic View for FABP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP2 Gene

Regulatory Elements for FABP2 Gene

Proteins for FABP2 Gene

  • Protein details for FABP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12104-FABPI_HUMAN
    Recommended name:
    Fatty acid-binding protein, intestinal
    Protein Accession:
    P12104
    Secondary Accessions:
    • Q2NKJ1

    Protein attributes for FABP2 Gene

    Size:
    132 amino acids
    Molecular mass:
    15207 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP2 Gene

neXtProt entry for FABP2 Gene

Proteomics data for FABP2 Gene at MOPED

Post-translational modifications for FABP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP2 Gene

Domains for FABP2 Gene

Gene Families for FABP2 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for FABP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12104

UniProtKB/Swiss-Prot:

FABPI_HUMAN
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior:
    • P12104
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.:
    • P12104
genes like me logo Genes that share domains with FABP2: view

Function for FABP2 Gene

Molecular function for FABP2 Gene

GENATLAS Biochemistry: fatty acid binding protein 2,intestinal
UniProtKB/Swiss-Prot Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor
UniProtKB/Swiss-Prot Induction: By EGF.

Gene Ontology (GO) - Molecular Function for FABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005504 fatty acid binding TAS 2824476
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FABP2: view
genes like me logo Genes that share phenotypes with FABP2: view

Animal Models for FABP2 Gene

MGI Knock Outs for FABP2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FABP2 Gene

Localization for FABP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP2 Gene COMPARTMENTS Subcellular localization image for FABP2 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP2: view

Pathways for FABP2 Gene

genes like me logo Genes that share pathways with FABP2: view

Pathways by source for FABP2 Gene

2 KEGG pathways for FABP2 Gene

Interacting Proteins for FABP2 Gene

Gene Ontology (GO) - Biological Process for FABP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007586 digestion TAS 7883976
GO:0019433 triglyceride catabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FABP2: view

Compounds for FABP2 Gene

(32) HMDB Compounds for FABP2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(6) Drugbank Compounds for FABP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Arachidonic Acid
506-32-1 carrier
Estradiol
  • 17beta oestradiol
50-28-2 carrier
Ibuprofen
  • Ibuprophen
15687-27-1 target binder
MYRISTIC ACID
carrier
Palmitic Acid
  • 1-Hexyldecanoic Acid
57-10-3 carrier

(34) Novoseek inferred chemical compound relationships for FABP2 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 87.3 220
acrylodan 73.1 7
oleic acid 62.1 10
pyridoxamine 60.1 3
palmitate 55.2 8
genes like me logo Genes that share compounds with FABP2: view

Transcripts for FABP2 Gene

mRNA/cDNA for FABP2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FABP2 Gene

Fatty acid binding protein 2, intestinal:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FABP2 Gene

No ASD Table

Relevant External Links for FABP2 Gene

GeneLoc Exon Structure for
FABP2
ECgene alternative splicing isoforms for
FABP2

Expression for FABP2 Gene

mRNA expression in normal human tissues for FABP2 Gene

mRNA differential expression in normal tissues according to GTEx for FABP2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (41.4) and Colon - Transverse (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FABP2 Gene

SOURCE GeneReport for Unigene cluster for FABP2 Gene Hs.282265

mRNA Expression by UniProt/SwissProt for FABP2 Gene

P12104-FABPI_HUMAN
Tissue specificity: Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.
genes like me logo Genes that share expressions with FABP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FABP2 Gene

Orthologs for FABP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP2 35
  • 97.73 (n)
  • 96.97 (a)
FABP2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP2 35
  • 86.11 (n)
  • 84.09 (a)
FABP2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP2 35
  • 89.14 (n)
  • 86.36 (a)
FABP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp2 35
  • 82.07 (n)
  • 78.03 (a)
Fabp2 16
Fabp2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FABP2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FABP2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp2 35
  • 83.08 (n)
  • 81.82 (a)
chicken
(Gallus gallus)
Aves FABP2 35
  • 71.46 (n)
  • 70.45 (a)
FABP2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fabp2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp2 35
  • 70.74 (n)
  • 71.76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9035 35
zebrafish
(Danio rerio)
Actinopterygii fabp2 35
  • 67.94 (n)
  • 67.18 (a)
fabp2 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fabp 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lbp-5 36
  • 29 (a)
ManyToMany
lbp-6 36
  • 29 (a)
ManyToMany
lbp-7 36
  • 26 (a)
ManyToMany
lbp-8 36
  • 23 (a)
ManyToMany
lbp-9 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4242 36
  • 33 (a)
OneToOne
Species with no ortholog for FABP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP2 Gene

ENSEMBL:
Gene Tree for FABP2 (if available)
TreeFam:
Gene Tree for FABP2 (if available)

Paralogs for FABP2 Gene

Paralogs for FABP2 Gene

Selected SIMAP similar genes for FABP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FABP2: view

Variants for FABP2 Gene

Sequence variations from dbSNP and Humsavar for FABP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2964 -- 119,318,976(+) ATAAA(C/T)AGTTC utr-variant-3-prime
rs714899 -- 119,321,880(+) AGGGA(A/G)AATAT intron-variant
rs878372 -- 119,317,625(-) CTTAC(G/T)ACTTG utr-variant-3-prime
rs907204 -- 119,317,499(+) AACAC(A/G)CAGTA utr-variant-3-prime
rs907205 -- 119,317,509(+) ATTCA(C/G)CTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FABP2 Gene

Variant ID Type Subtype PubMed ID
nsv879840 CNV Gain 21882294

Relevant External Links for FABP2 Gene

HapMap Linkage Disequilibrium report
FABP2
Human Gene Mutation Database (HGMD)
FABP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP2 Gene

Disorders for FABP2 Gene

(1) University of Copenhagen DISEASES for FABP2 Gene

(32) Novoseek inferred disease relationships for FABP2 Gene

Disease -log(P) Hits PubMed IDs
intestinal ischemia 74.9 15
insulin resistance 64.1 50
necrosis bowel 53.2 2
mesenteric infarction 50.6 4
niddm 49.7 18

Genatlas disease for FABP2 Gene

insulin resistance,increased fatty oxidation in Pima Indian population (FABP2 polymorphism,A94T)

Relevant External Links for FABP2

Genetic Association Database (GAD)
FABP2
Human Genome Epidemiology (HuGE) Navigator
FABP2
genes like me logo Genes that share disorders with FABP2: view

No data available for UniProtKB/Swiss-Prot for FABP2 Gene

Publications for FABP2 Gene

  1. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. (PMID: 7883976) Baier L.J. … Prochazka M. (J. Clin. Invest. 1995) 3 4 23 48
  2. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. (PMID: 9204553) Zhang F. … Hamilton J.A. (J. Biomol. NMR 1997) 3 4 23
  3. Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells. (PMID: 10070036) Darimont C. … de Pover A. (Am. J. Physiol. 1999) 3 4 23
  4. Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men. (PMID: 11288045) Kim C.H. … Suh K.I. (Metab. Clin. Exp. 2001) 3 23 48
  5. The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians. (PMID: 11299043) Chiu K.C. … Yoon C. (BMC Genet. 2001) 3 23 48

Products for FABP2 Gene

Sources for FABP2 Gene

Back to Top

Content