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FABP2 Gene

protein-coding   GIFtS: 64
GCID: GC04M120238

Fatty Acid Binding Protein 2, Intestinal

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Binding Protein 2, Intestinal1 2
Fatty Acid-Binding Protein 22 3
Intestinal-Type Fatty Acid-Binding Protein2 3
FABPI2 3
I-FABP2 3
Fatty Acid-Binding Protein, Intestinal2

External Ids:    HGNC: 35561   Entrez Gene: 21692   Ensembl: ENSG000001453847   OMIM: 1346405   UniProtKB: P121043   

Export aliases for FABP2 gene to outside databases

Previous GC identifers: GC04M120996 GC04M120518 GC04M120631 GC04M120697 GC04M120596 GC04M115960


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FABP2 Gene:
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified
members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type.
They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or
transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and
proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic
protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an
alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat
oxidation and insulin resistance. (provided by RefSeq, Jul 2008)

GeneCards Summary for FABP2 Gene:
FABP2 (fatty acid binding protein 2, intestinal) is a protein-coding gene. Diseases associated with FABP2 include intestinal atresia, and intestinal disease. GO annotations related to this gene include long-chain fatty acid transporter activity and fatty acid binding. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their
acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated
long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty
acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor

Gene Wiki entry for FABP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FABP2 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFABP2 promoter sequence
   Search Chromatin IP Primers for FABP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FABP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28-q31   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q28-q31

FABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M120238:  view genomic region     (about GC identifiers)

Start:
120,238,405 bp from pter      End:
120,243,545 bp from pter
Size:
5,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104 (See protein sequence)
Recommended Name: Fatty acid-binding protein, intestinal  
Size: 132 amino acids; 15207 Da
4 PDB 3D structures from and Proteopedia for FABP2:
1KZW (3D)        1KZX (3D)        3AKM (3D)        3IFB (3D)    
Secondary accessions: Q2NKJ1

Explore the universe of human proteins at neXtProt for FABP2: NX_P12104

Explore proteomics data for FABP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FABP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000125.2  
    ENSEMBL proteins: 
     ENSP00000274024  

    FABP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P12104

    ProtoNet protein and cluster: P12104

    1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    FABP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FABPI_HUMAN, P12104
    Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their
    acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated
    long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty
    acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor
    Induction: By EGF

         Genatlas biochemistry entry for FABP2:
    fatty acid binding protein 2,intestinal

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005324long-chain fatty acid transporter activity ----
    GO:0005504fatty acid binding TAS2824476
         
    FABP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FABP2:
     Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fabp2):
     adipose tissue  growth/size/body  homeostasis/metabolism  liver/biliary system  renal/urinary system 

    FABP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fabp2tm1Mto for FABP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FABP2
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    miRNA
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    hsa-miR-3163 hsa-miR-3607-5p hsa-miR-16-2* hsa-miR-3688-3p hsa-miR-374b hsa-miR-1271 hsa-miR-374a hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidFABP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FABPI_HUMAN, P12104: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus2
    plasma membrane2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0005902microvillus ----
    GO:0045179apical cortex ----

    FABP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FABP2 About    
    See pathways by source

    SuperPathContained pathways About
    1PPAR signaling pathway
    PPAR signaling pathway
    2Fat digestion and absorption
    Fat digestion and absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for FABP2):
        PPAR signaling pathway
    Fat digestion and absorption


    FABP2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP2: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FABP2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for FABP2 (P121043 ENSP000002740244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLGNO149673I2D: score=1 
    TERF2IPENSP000003000864STRING: ENSP00000300086
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process ----
    GO:0007586digestion TAS7883976
    GO:0050892intestinal absorption ----

    FABP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FABP2 (FABPI)

    Selected HMDB Compounds for FABP2 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    6 DrugBank Compounds for FABP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arachidonic Acid-- 506-32-1carrier--19398502
    Estradiol17beta oestradiol (see all 7)50-28-2carrier--19398502
    IbuprofenIbuprophen (see all 3)15687-27-1targetbinder15722357
    MYRISTIC ACID-- --carrier--10592235
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3carrier--10592235
    SulfinpyrazoneDiphenylpyrazone (see all 6)57-96-5carrier--19398502

    Selected Novoseek inferred chemical compound relationships for FABP2 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 87.3 527 10627505 (6), 9516437 (5), 18235139 (5), 19730255 (4) (see all 99)
    acrylodan 73.1 11 9199809 (3), 10331662 (1), 8626681 (1), 8422363 (1) (see all 5)
    oleic acid 62.1 12 8652536 (2), 12809510 (2), 19309727 (1), 9931262 (1) (see all 8)
    pyridoxamine 60.1 4 11353536 (1), 11553487 (1), 10999478 (1)
    palmitate 55.2 12 10070036 (2), 16361342 (1), 19125316 (1), 17165722 (1) (see all 7)
    lipid 55.1 60 12370850 (3), 12634920 (3), 16297872 (2), 12809489 (2) (see all 34)
    clostripain 53.2 3 16229473 (1), 12809510 (1)
    threonine 50.7 35 10229304 (2), 11124746 (2), 9179548 (2), 16013194 (1) (see all 17)
    triacylglycerol 43.8 13 11876264 (3), 12646232 (2), 18065580 (2), 17209184 (1) (see all 5)
    glucose 42.5 28 11423496 (2), 16311100 (2), 9181478 (2), 7657027 (1) (see all 17)



    FABP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FABP2 gene: 
    NM_000134.3  

    Unigene Cluster for FABP2:

    Fatty acid binding protein 2, intestinal
    Hs.282265  [show with all ESTs]
    Unigene Representative Sequence: NM_000134
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274024(uc003icw.3)
    miRNA
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    Additional mRNA sequence: 

    AK025079.1 BC069466.1 BC069617.1 BC069625.1 BC069637.1 BC111791.1 

    2 DOTS entries:

    DT.40194860  DT.91937785 

    13 AceView cDNA sequences:

    BC069637 BC069466 AK025079 NM_000134 BX280932 BF591167 BQ010664 CF529938 
    BF002011 BC069625 BC069617 AW605378 AA587057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FABP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAGCAAA
    FABP2 Expression
    About this image

    FABP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FABP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282265

    UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
    Tissue specificity: Expressed in the small intestine and at much lower levels in the large intestine. Highest
    expression levels in the jejunum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FABP2: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FABP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fabp21 , 5 fatty acid binding protein 2, intestinal1, 5 82.07(n)1
    78.03(a)1
      3 (53.74 cM)5
    140791  NM_007980.31  NP_032006.11 
     1228950725 
    chicken
    (Gallus gallus)
    Aves FABP21 fatty acid binding protein 2, intestinal 71.46(n)
    70.45(a)
      422678  NM_001007923.1  NP_001007924.1 
    lizard
    (Anolis carolinensis)
    Reptilia FABP26
    fatty acid binding protein 2, intestinal
    72(a)
    1 ↔ 1
    5(140026497-140032841)
    African clawed frog
    (Xenopus laevis)
    Amphibia fabp2-A2 fatty acid binding protein 2, intestinal 75.38(n)    L19946.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fabp22 fatty acid binding protein 2, intestinal 77.22(n)   30708  AF180921.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta fabp6
    fatty acid bindin protein
    27(a)
    1 → many
    3R(7385612-7392771)
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-56
    lbp-66
    (see all 5)
    Protein LBP-6 (lbp-6) mRNA, complete cds
    (see all 5)
    29(a)
    29(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    I(6731269-6732280) WBGene00002257
    I(6728285-6729376) WBGene00002258


    ENSEMBL Gene Tree for FABP2 (if available)
    TreeFam Gene Tree for FABP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FABP2 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  FABP32  RBP12  
    RBP22  CRABP12  PMP22  FABP72  RBP72  
    13 SIMAP similar genes for FABP2 using alignment to 1 protein entry:     FABPI_HUMAN:
    DKFZp547J2313    FABP7    FABP3    FABP9    CRABP2    FABP4
    PMP2    RBP2    FABP5    FABP12    CRABP1    FABP6
    RBP1

    FABP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FABP2 (see all 216)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17998831,2,,4
    C,F,O,Hnon-pathogenic1120035442(-) CAAGCA/C/G/
            
    CTTTT
    2 T A mis131EA NA NS WA CSA EU 8223
    rs58614221,2
    C--115965164(+) ATCTT-/A/TGAACC 1 -- us2k13NA CSA 6
    rs58614241,2
    C--115965244(+) TATTA-/C/    
       TC
    /TT
    ATTAA
    1 -- us2k1 tfbs31CSA 2
    rs772157791,2
    C--115965245(+) TTATT-/CT/TC 
            
    NAATT
    1 -- us2k10--------
    rs1158125631,2
    C,F--120031525(+) AATAGA/GTAAGT 1 -- ds50011Minor allele frequency- G:0.11WA 118
    rs623284201,2
    C,F--120031729(+) GACTTT/CGTACA 1 -- ds50017Minor allele frequency- C:0.14NA WA EA 366
    rs752457871,2
    C,F--120031763(+) CTTTGT/CGCCTT 1 -- ds50011Minor allele frequency- C:0.04NA 120
    rs1154549881,2
    C,F--120031786(+) TTTTTG/TTATTG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1929430351,2
    --120031857(+) AAATAC/TATTGA 1 -- ds50010--------
    rs1834658591,2
    --120031895(+) TCTAAA/GTAATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FABP2 (120238405 - 120243545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FABP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879840CNV Gain21882294

    Human Gene Mutation Database (HGMD): FABP2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FABP2
    DNA2.0 Custom Variant and Variant Library Synthesis for FABP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134640    OMIM disorders: --

    Selected diseases for FABP2 (see all 44):    
    About MalaCards
    intestinal atresia    intestinal disease    cerebrovascular disease    carotid stenosis
    familial combined hyperlipidemia    hyperuricemia    insulin resistance    piebaldism
    morbid obesity    obesity, association with    kidney cancer    familial hypercholesterolemia
    hypertriglyceridemia    hypercholesterolemia    coronary heart disease    fatty liver disease
    maturity-onset diabetes of the young    acute pancreatitis    hepatitis    atherosclerosis

    1 disease from the University of Copenhagen DISEASES database for FABP2:
    Diabetes mellitus

    FABP2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FABP2 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intestinal ischemia 74.9 24 7797132 (3), 15120958 (2), 11592792 (1), 19279473 (1) (see all 12)
    insulin resistance 64.1 68 19439328 (4), 11299043 (3), 10337870 (3), 11422402 (3) (see all 31)
    necrosis bowel 53.2 3 20485148 (1), 16971202 (1)
    mesenteric infarction 50.6 4 8566578 (4)
    niddm 49.7 24 9589253 (3), 20329566 (2), 19324445 (2), 15776585 (2) (see all 13)
    hyperlipidemia familial combined 48.4 2 9194752 (1), 12370850 (1)
    insulin sensitivity 46.3 22 18422024 (3), 16002819 (3), 17921407 (2), 11555846 (2) (see all 11)
    hypertriglyceridemia 45.4 8 19768241 (1), 16908951 (1), 17684408 (1), 15547295 (1) (see all 6)
    dyslipidemia 41.3 10 11866034 (3), 12161503 (2), 9194752 (1), 20047744 (1) (see all 7)
    obesity 39.1 42 10337870 (4), 11866034 (3), 17211557 (3), 15620432 (3) (see all 16)

    Genatlas disease: FABP2
    insulin resistance,increased fatty oxidation in Pima Indian population (FABP2 polymorphism,A94T)

    Genetic Association Database (GAD): FABP2
    Human Genome Epidemiology (HuGE) Navigator: FABP2 (107 documents)

    Export disorders for FABP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FABP2 gene, integrated from 10 sources (see all 347):
    (articles sorted by number of sources associating them with FABP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. (PubMed id 7883976)1, 2, 4, 9 Baier L.J.... Prochazka M. (J. Clin. Invest. 1995)
    2. The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots. (PubMed id 12899384)1, 2, 4 Kunsan X....Rong Z. (Chin. Med. Sci. J. 1999)
    3. Association between functional FABP2 promoter haplotype and type 2 diabetes. (PubMed id 16718625)1, 4, 9 Li Y....DAPring F. (Horm. Metab. Res. 2006)
    4. The effects of retinol on postprandial parameters in men with different FABP2 promoter haplotypes. (PubMed id 17447159)1, 4, 9 Helwig U....Schrezenmeir J. (Horm. Metab. Res. 2007)
    5. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. (PubMed id 9204553)1, 2, 9 Zhang F.... Hamilton J.A. (J. Biomol. NMR 1997)
    6. The Ala54Thr polymorphism in the fatty acid-binding protein 2 (FABP2) gene is associated with hearing impairment: a preliminary report. (PubMed id 20202768)1, 4, 9 Uchida Y....Shimokata H. (Auris Nasus Larynx 2010)
    7. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. (PubMed id 14563446)1, 2, 9 Pelsers M.M.A.L.... Glatz J.F.C. (Clin. Biochem. 2003)
    8. Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) study. (PubMed id 19439328)1, 4, 9 Chamberlain A.M....Boerwinkle E. (Metab. Clin. Exp. 2009)
    9. Association between functional FABP2 promoter haplotypes and body mass index: analyses of 8072 participants of the KORA cohort study. (PubMed id 19156719)1, 4, 9 BAPhme M....Illig T. (amp 2009)
    10. Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile. (PubMed id 17211557)1, 4, 9 PAcrez-Bravo F....Albala C. (Acta Diabetol 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2169 HGNC: 3556 AceView: FABP2 Ensembl:ENSG00000145384 euGenes: HUgn2169
    ECgene: FABP2 Kegg: 2169 H-InvDB: FABP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FABP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FABP2 gene:
    Search GeneIP for patents involving FABP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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