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FABP2 Gene

protein-coding   GIFtS: 62

GC04M120518
fatty acid binding protein 2, intestinal
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FABPI 2, 3
I-FABP 1, 2, 3
MGC133132 2
Descriptions
fatty acid binding protein 2, intestinal 2
intestinal fatty acid binding protein 2 2
External Ids
HGNC: 35561
Entrez Gene: 21692
UniProtKB: P121043
Ensembl: ENSG000001453847
Search outside databases for aliases for FABP2 gene

Previous GC identifers: GC04M120996 GC04M120631 GC04M120697 GC04M120596

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FABP2:
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly
twenty identified members. FABPs are divided into at least three distinct types, namely the
hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to
participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids.
They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty
acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small
intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an
alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with
increased fat oxidation and insulin resistance. [provided by RefSeq]

UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids
and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis.
Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to
unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning
as a lipid sensor

Gene Wiki entry for FABP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FABP2 gene  

Entrez Gene cytogenetic band: 4q28-q31   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q28-q31

FABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M120518:     (about GC identifiers)

Start:
120,457,853 bp from pter
End:
120,462,766 bp from pter
Size:
4,914 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104 (See protein sequence)
Recommended Name: Fatty acid-binding protein, intestinal  
Size: 132 amino acids; 15207 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1KZW (3D)    1KZX (3D)    3IFB (3D)    
Secondary accessions: Q2NKJ1

REFSEQ proteins: NP_000125.2  

ENSEMBL proteins: 
ENSP00000274024 


Human Recombinant Proteins 
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R&D Systems Recombinant & Natural Proteins for FABP2
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (intestinal FABP)
Human Recombinant Proteins from Abnova (FABP2)
              OriGene Purified Recombinant Human Protein: FABP2 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
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Antibodies for FABP2: 
Browse Antibodies Central at Invitrogen
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Sigma-Aldrich Antibodies for FABP2
R&D Systems Antibodies for FABP2
Antibodies from Abcam (intestinal FABP), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (FABP2)
Novus Biologicals Antibodies for FABP2

Assays for FABP2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR000463 Fatty_acid_bd
 IPR000566 Lipocln_cytFABP


   GeneDecks  FABP2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P12104

ProtoNet protein and cluster: P12104

1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FABP2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FABP2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000134

              Applied Biosystems Silencer® siRNAs for FABP2

              Sigma-Aldrich siRNA for FABP2  
                     Sigma-Aldrich shRNA for FABP2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000134
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000134
                                 untagged cDNA clone in CMV expression vector: NM_000134 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000134

UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids
and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis.
Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to
unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning
as a lipid sensor
Induction: By EGF

Genatlas biochemistry entry for FABP2:
fatty acid binding protein 2,intestinal

5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fabp2):

adipose tissuegrowth/sizehomeostasis/metabolismliver/biliary systemrenal/urinary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005215 transporter activity IEA--
GO:0005504 fatty acid binding TAS2824476
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for  FABP2  (Your Favorite Gene powered by Ingenuity) 
 Maturity Onset Diabetes of Young (MODY) Signaling
 LPS/IL-1 Mediated Inhibition of RXR Function

   GeneDecks  FABP2 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for FABP2):
 hsa03320 PPAR signaling pathway

   GeneDecks  FABP2 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  FABP2 


5/23 Interacting proteins for FABP2 (ENSP000002740243) via UniProtKB, MINT, and/or STRING (see all 23 )
InteractantInteraction Details
GeneCardExternal ID(s)
FANCBENSP000003268193STRING (score=.958)
IRAK1ENSP000003589973STRING (score=.918)
GOT2ENSP000002452063STRING (score=.917)
FABP3ENSP000003628173STRING (score=.913)
HSD17B8ENSP000003637943STRING (score=.899)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006810 transport IEA--
GO:0007586 digestion TAS7883976
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for FABP2:
Antagonist

Browse Tocris compounds for FABP2
10/22 Novoseek chemical compound relationships for FABP2 gene (see all 22 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid 87.08 479 10627505 (6), 9516437 (5), 18235139 (5), 15722357 (4) (see all 99)
acrylodan 74.21 11 9199809 (3), 10331662 (1), 8626681 (1), 8422363 (1) (see all 5)
oleic acid 63.78 12 8652536 (2), 12809510 (2), 19309727 (1), 9931262 (1) (see all 8)
lipid 54.71 57 12370850 (3), 12634920 (3), 16297872 (2), 12809489 (2) (see all 32)
clostripain 54.30 3 16229473 (1), 12809510 (1)
threonine 51.21 33 10229304 (2), 11124746 (2), 9179548 (2), 16013194 (1) (see all 16)
triacylglycerol 45.84 13 11876264 (3), 12646232 (2), 18065580 (2), 17209184 (1) (see all 5)
glucose 43.10 27 11423496 (2), 16311100 (2), 9181478 (2), 7657027 (1) (see all 16)
cholesterol 40.88 6 18235139 (2), 8218286 (1), 16718625 (1), 9181478 (1) (see all 5)
carboxylate 37.24 3 9516437 (1), 12200543 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FABP2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FABP2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000134

              Sigma-Aldrich siRNA for FABP2  
                     Sigma-Aldrich shRNA for FABP2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000134  

REFSEQ mRNAs for FABP2 gene: 

NM_000134.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000134  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000134
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000134
                                 untagged cDNA clone in CMV expression vector: NM_000134 

Additional cDNA sequence: 

AK025079.1 BC069466.1 BC069617.1 BC069625.1 BC069637.1 BC111791.1 

2 DOTS entries:

DT.40194860  DT.91937785 

13 AceView cDNA sequences:

BC069466 BC069637 CF529938 BX280932 BQ010664 AK025079 BF002011 BF591167 
BC069625 NM_000134 AW605378 BC069617 AA587057 

highest scoring ESTs for FABP2:

AK025079 AW605378 BC069466 BC069617 BC069625 BC069637 BX280932 BF002011 BF591167 BQ010664 

Unigene Cluster for FABP2:

Fatty acid binding protein 2, intestinal
Hs.282265  [show with all ESTs]
Unigene Representative Sequence: NM_000134


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000274024  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FABP2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FABP2

1 / 2 / 3

3 probe-sets matching FABP2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

38587_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M18079 0.20 1.00 0.72 1

207475_at2, 3 U133-A 2 1.00 0.95 -- -- NM_000134 0.60 1.00 0.82 1

207475_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCAAAGCAAA

SOURCE GeneReport for Unigene cluster: Hs.282265

Expression variation in blood from EXPOLDB for FABP2

UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
Tissue specificity: Expressed in the small intestine and at much lower levels in the large
intestine. Highest expression levels in the jejunum

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for FABP2 gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
FABP21   -- fatty acid binding protein 2, intestinal 88.38(n)
85.61(a)
487924  XM_545047.2  XP_545047.1 
chimpanzee
(Pan troglodytes)
FABP21   -- fatty acid binding protein 2, intestinal 97.98(n)
97.73(a)
740421  XM_001149448.1  XP_001149448.1 
cow
(Bos taurus)
FABP21   -- fatty acid binding protein 2, intestinal 86.11(n)
83.33(a)
515768  NM_001025332.1  NP_001020503.1 
rat
(Rattus norvegicus)
Fabp21   -- fatty acid binding protein 2, intestinal 82.32(n)
81.82(a)
25598  NM_013068.1  NP_037200.1 
mouse
(Mus musculus)
Fabp21, 5 3 (55.00 cM)5
fatty acid binding protein 2, intestinal1, 5 81.31(n)1
78.03(a)1
140791  NM_007980.21  NP_032006.11 
 AK0079955  AY5238185  (see all 9)
About this table        Species with no ortholog for FABP2

ENSEMBL Gene Tree for FABP2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FABP2 gene
RBP12  RBP22  RBP52  RBP72  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/90 NCBI SNPs in FABP2 are shown (see all 90 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 94)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs22826881,2
A,C,F,H,O120463170(-) CTTTAG/ACTTTT 1 -- ng3112Minor allele frequency- A:0.45NS NA EU EA WA 648
rs8783721,2
C,F,H,O120458228(-) CTTACT/GACTTG 1 -- ut31 ese321Minor allele frequency- G:0.33EA NA NS MN EU WA 1406
rs117247581,2
A,C,F,H120459326(+) AAACAG/ATCTGT 1 -- ut31 ese311Minor allele frequency- A:0.47EU EA WA NA 980
rs99997241,2
A,C,F,H120459392(+) ATGGAC/TGCAAT 1 -- ut31 ese37Minor allele frequency- T:0.32EU EA WA NA 552
rs15110241,2
C,F,H,O120459629(+) CTGTGC/TGCCAA 1 -- ut31 ese37Minor allele frequency- T:0.32MN NA EU EA 576
rs9072051,2
A,C,F,H120458112(+) attcaG/Cctttc 1 -- ut31 ese313Minor allele frequency- C:0.30NS MN EU EA WA NA 840
--
rs100345791,2
A,C,F,H120463477(+) TCTCAC/ATGCCT 1 -- ng317Minor allele frequency- A:0.45NA EU EA WA 546
rs29641,2
A,C,F,O120459579(+) ATAAAT/CAGTTC 1 -- ut315Minor allele frequency- C:0.23MN NA 336
rs17998831,2
C,F,H,O120461350(-) CAAGCA/C/G/
        
CTTTT
3 T/P T/A T/S mis113EA NA EU WA 1114
--
rs9072041,2
A,C,F120458102(+) aacacG/Acagta 1 -- ut31 ese31Minor allele frequency- A:0.29MN 184
About this table

HapMap Linkage Disequilibrium images for FABP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134640

10/31 Novoseek disease relationships for FABP2 gene (see all 31 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
intestinal ischemia 72.21 23 7797132 (3), 15120958 (2), 11592792 (1), 19279473 (1) (see all 11)
insulin resistance 64.34 59 11299043 (3), 10337870 (3), 11422402 (3), 17211557 (3) (see all 27)
mesenteric infarction 51.87 4 8566578 (4)
niddm 50.68 22 9589253 (3), 19324445 (2), 15776585 (2), 10229304 (1) (see all 12)
hyperlipidemia familial combined 50.04 2 9194752 (1), 12370850 (1)
insulin sensitivity 48.74 22 18422024 (3), 16002819 (3), 17921407 (2), 11555846 (2) (see all 11)
necrosis bowel 47.77 1 16971202 (1)
hypertriglyceridemia 44.58 6 16908951 (1), 17684408 (1), 15547295 (1), 16919542 (1) (see all 5)
dyslipidemia 41.65 9 11866034 (3), 12161503 (2), 9194752 (1), 10337870 (1) (see all 6)
hyperuricemia 41.55 3 10337870 (1), 15135268 (1)
About this table

Genatlas disease: FABP2
insulin resistance,increased fatty oxidation in Pima Indian population (FABP2 polymorphism,A94T)

Human Gene Mutation Database: FABP2
Genetic Association Database: FABP2
Human Genome Epidemiology Navigator: FABP2 (75 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/283 PubMed articles for FABP2 gene (see all 283 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2169 HGNC: 3556 AceView: FABP2 Ensembl:ENSG00000145384 euGenes: HUgn2169
ECgene: FABP2 H-InvDB: FABP2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FABP2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
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 Tagged/untagged cDNA clones
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 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for FABP2




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