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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FABP2 Gene

protein-coding   GIFtS: 66
GCID: GC04M120238

fatty acid binding protein 2, intestinal
 Explore 49 diseases affiliated with
FABP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FABP2    

Aliases
for FABP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fatty Acid Binding Protein 2, Intestinal1 2
I-FABP1 2 3
Fatty Acid-Binding Protein 22 3
Intestinal-Type Fatty Acid-Binding Protein2 3
FABPI2 3
Fatty Acid-Binding Protein, Intestinal2

External Ids:    HGNC: 35561   Entrez Gene: 21692   Ensembl: ENSG000001453847   OMIM: 1346405   UniProtKB: P121043   

Export aliases for FABP2 gene to outside databases

Previous GC identifers: GC04M120996 GC04M120518 GC04M120631 GC04M120697 GC04M120596 GC04M115960


Summaries
for FABP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FABP2:
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified
members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They
form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of
long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal
fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine
epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a
threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA
esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids
with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help
maintain energy homeostasis by functioning as a lipid sensor

Gene Wiki entry for FABP2


Genomic Views
for FABP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FABP2 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FABP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FABP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28-q31   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q28-q31

FABP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M120238:  view genomic region     (about GC identifiers)

Start:
 120,238,405 bp from pter      End:
 120,243,545 bp from pter
Size:
 5,141 bases      Orientation:
 minus strand

Proteins
for FABP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104 (See protein sequence)
Recommended Name: Fatty acid-binding protein, intestinal  
Size: 132 amino acids; 15207 Da
Subcellular location: Cytoplasm
4 PDB 3D structures from and Proteopedia for FABP2:
1KZW (3D)        1KZX (3D)        3AKM (3D)        3IFB (3D)    
Secondary accessions: Q2NKJ1

Explore the universe of human proteins at neXtProt for FABP2: NX_P12104

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12104

    • FABP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000125.2  
    ENSEMBL proteins: 
     ENSP00000274024  

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    Uscn Proteins for FABP2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0005902microvillus IEA--
    GO:0044424intracellular part ----
    GO:0045179apical cortex IEA--


    FABP2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FABP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FABP2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P12104

    ProtoNet protein and cluster: P12104

    1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    Function
    for FABP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
    Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA
    esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids
    with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help
    maintain energy homeostasis by functioning as a lipid sensor
    Induction: By EGF

         Genatlas biochemistry entry for FABP2:
    fatty acid binding protein 2,intestinal

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005324long-chain fatty acid transporter activity IEA--
    GO:0005504fatty acid binding IEA--


    FABP2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FABP2:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Fabp2tm1Mto for FABP2
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fabp2):
     adipose tissue  growth/size  homeostasis/metabolism  liver/biliary system  renal/urinary system 

    FABP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FABP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PPAR signaling pathway
    		PPAR signaling pathway1.00
    2alpha-Linolenic acid metabolism
    		Fat digestion and absorption0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for FABP2):
        PPAR signaling pathway
    Fat digestion and absorption


    FABP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FABP2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for FABP2 (P121043 ENSP000002740244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLGNO149673I2D: score=1 
    TERF2IPENSP000003000864STRING: ENSP00000300086
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0007586digestion TAS7883976
    GO:0015908fatty acid transport ----
    GO:0015909long-chain fatty acid transport ----
    GO:0050892intestinal absorption IEA--


    FABP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FABP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FABP2 for compounds           About GeneDecksing

    EMD Millipore small molecules for FABP2:
    Small Molecule - inhibitor
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    Browse Tocris compounds for FABP2

    10/32 HMDB Compounds for FABP2 (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    5 DrugBank Compounds for FABP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arachidonic Acid-- 506-32-1carrier--19398502
    Estradiol17beta oestradiol (see all 7)50-28-2carrier--19398502
    MYRISTIC ACID-- --carrier--10592235
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3carrier--10592235
    SulfinpyrazoneDiphenylpyrazone (see all 6)57-96-5carrier--19398502

    10/34 Novoseek chemical compound relationships for FABP2 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 87.3 527 10627505 (6), 9516437 (5), 18235139 (5), 19730255 (4) (see all 99)
    acrylodan 73.1 11 9199809 (3), 10331662 (1), 8626681 (1), 8422363 (1) (see all 5)
    oleic acid 62.1 12 8652536 (2), 12809510 (2), 19309727 (1), 9931262 (1) (see all 8)
    pyridoxamine 60.1 4 11353536 (1), 11553487 (1), 10999478 (1)
    palmitate 55.2 12 10070036 (2), 16361342 (1), 19125316 (1), 17165722 (1) (see all 7)
    lipid 55.1 60 12370850 (3), 12634920 (3), 16297872 (2), 12809489 (2) (see all 34)
    clostripain 53.2 3 16229473 (1), 12809510 (1)
    threonine 50.7 35 10229304 (2), 11124746 (2), 9179548 (2), 16013194 (1) (see all 17)
    triacylglycerol 43.8 13 11876264 (3), 12646232 (2), 18065580 (2), 17209184 (1) (see all 5)
    glucose 42.5 28 11423496 (2), 16311100 (2), 9181478 (2), 7657027 (1) (see all 17)

    Search CenterWatch for drugs/clinical trials and news about FABP2 / FABPI 

    Transcripts
    for FABP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FABP2 gene: 
    NM_000134.3  

    Unigene Cluster for FABP2:

    Fatty acid binding protein 2, intestinal
    Hs.282265  [show with all ESTs]
    Unigene Representative Sequence: NM_000134
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274024(uc003icw.3)

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK025079.1 BC069466.1 BC069617.1 BC069625.1 BC069637.1 BC111791.1 

    2 DOTS entries:

    DT.40194860  DT.91937785 

    13 AceView cDNA sequences:

    BC069466 BC069637 BX280932 CF529938 BC069625 BF002011 BQ010664 NM_000134 
    BF591167 AK025079 BC069617 AW605378 AA587057 

    GeneLoc Exon Structure


    Expression
    for FABP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FABP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAAAGCAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FABP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FABP2

    SOURCE GeneReport for Unigene cluster: Hs.282265

    UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104
    Tissue specificity: Expressed in the small intestine and at much lower levels in the large intestine. Highest
    expression levels in the jejunum

        SABiosciences Expression via Pathway-Focused PCR Arrays including FABP2: 
              Fatty Acid Metabolism in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
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    Orthologs
    for FABP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FABP2 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fabp21 , 5 fatty acid binding protein 2, intestinal1, 5 82.07(n)1
    78.03(a)1    		   3 (53.74 cM)5
    140791  NM_007980.21  NP_032006.11 
     1228950725 
    chicken
    (Gallus gallus)    		 Aves FABP21 fatty acid binding protein 2, intestinal 71.46(n)
    70.45(a)    		   422678  NM_001007923.1  NP_001007924.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FABP26
    		 --
    		 71(a)
    		 1 ↔ 1
    		 5(140027471-140032490)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fabp2-A2 fatty acid binding protein 2, intestinal 75.38(n)    L19946.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fabp22 fatty acid binding protein 2, intestinal 77.22(n)   30708  AF180921.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fabp6
    		 fatty acid bindin protein
    		 24(a)
    		 possible ortholog
    		 3R(7385612-7392771)


    ENSEMBL Gene Tree for FABP2 (if available)
    TreeFam Gene Tree for FABP2 (if available) 

    Paralogs
    for FABP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FABP2 gene
    FABP52  RBP52  FABP92  CRABP22  FABP122  FABP42  RBP12  FABP32  
    CRABP12  RBP22  PMP22  FABP72  RBP72  
    13 SIMAP similar genes for FABP2 using alignment to 1 protein entry:     FABPI_HUMAN:
    DKFZp547J2313    FABP7    FABP3    FABP9    CRABP2    FABP4
    PMP2    RBP2    FABP5    FABP12    CRABP1    FABP6
    RBP1

    FABP2 for paralogs           About GeneDecksing



    Genomic Variants
    for FABP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FABP2
         2 CNVs: 80452 92353
    Human Gene Mutation Database (HGMD): FABP2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FABP2
    DNA2.0 Custom Variant and Variant Library Synthesis for FABP2

    Disorders / Diseases
    for FABP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FABP2 for disorders           About GeneDecksing

    OMIM gene information: 134640    OMIM disorders: --

    20/49 diseases for FABP2 (see all 49):    About MalaCards
    insulin resistance    retinol binding protein    maturity-onset diabetes of the young    hepatitis
    familial combined hyperlipidemia    type 2 diabetes mellitus    coronary heart disease    intestinal atresia
    carotid stenosis    diabetes mellitus    fatty liver disease    esophageal squamous cell carcinoma
    piebaldism    squamous cell carcinoma    cerebrovascular disease    hyperlipidemia
    hypercholesterolemia    familial hypercholesterolemia    alcohol dependence    morbid obesity

    1 disease from the University of Copenhagen DISEASES database for FABP2:
    Diabetes mellitus

    10/32 Novoseek disease relationships for FABP2 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intestinal ischemia 74.9 24 7797132 (3), 15120958 (2), 11592792 (1), 19279473 (1) (see all 12)
    insulin resistance 64.1 68 19439328 (4), 11299043 (3), 10337870 (3), 11422402 (3) (see all 31)
    necrosis bowel 53.2 3 20485148 (1), 16971202 (1)
    mesenteric infarction 50.6 4 8566578 (4)
    niddm 49.7 24 9589253 (3), 20329566 (2), 19324445 (2), 15776585 (2) (see all 13)
    hyperlipidemia familial combined 48.4 2 9194752 (1), 12370850 (1)
    insulin sensitivity 46.3 22 18422024 (3), 16002819 (3), 17921407 (2), 11555846 (2) (see all 11)
    hypertriglyceridemia 45.4 8 19768241 (1), 16908951 (1), 17684408 (1), 15547295 (1) (see all 6)
    dyslipidemia 41.3 10 11866034 (3), 12161503 (2), 9194752 (1), 20047744 (1) (see all 7)
    obesity 39.1 42 10337870 (4), 11866034 (3), 17211557 (3), 15620432 (3) (see all 16)

    Genatlas disease: FABP2
    insulin resistance,increased fatty oxidation in Pima Indian population (FABP2 polymorphism,A94T)

    Genetic Association Database (GAD): FABP2
    Human Genome Epidemiology (HuGE) Navigator: FABP2 (107 documents)

    Export disorders for FABP2 gene to outside databases

    Publications
    for FABP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FABP2 gene, integrated from 9 sources (see all 340):
    (articles sorted by number of sources associating them with FABP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. (PubMed id 7883976)1, 2, 4, 9 Baier L.J.... Prochazka M. (1995)
    2. The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots. (PubMed id 12899384)1, 2, 4 Kunsan X....Rong Z. (1999)
    3. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. (PubMed id 9204553)1, 2, 9 Zhang F.... Hamilton J.A. (1997)
    4. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. (PubMed id 14563446)1, 2, 9 Pelsers M.M.A.L.... Glatz J.F.C. (2003)
    5. Variation in the FABP2 promoter affects gene expression: implications for prior association studies. (PubMed id 14666368)1, 4, 9 Formanack M.L. and Baier L.J. (2004)
    6. Effects of intestinal fatty acid-binding protein gene Ala54Thr polymorphism and beta3-adrenergic receptor gene Trp64Arg polymorphism on insulin resistance and fasting plasma glucose in young to older Japanese men. (PubMed id 11699048)1, 4, 9 Ishii T....Saruta T. (2001)
    7. Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men. (PubMed id 11288045)1, 4, 9 Kim C.H....Suh K.I. (2001)
    8. Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity. (PubMed id 15620432)1, 4, 9 Takakura Y....Yoshida T. (2005)
    9. Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease. (PubMed id 12189904)1, 4, 9 Erkkila A.T....Uusitupa M.I. (2002)
    10. [Genetic polymorphism of pyruvate dehydrogenase kinase 4 (PDK4), paraoxonase 2 (PON2), and fatty acid binding protein 2 (FABP2) in the NIDDM population of Senegal] (PubMed id 15776585)1, 4, 9 Che D....Trivin F. (2002)

    External Searches for FABP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing FABP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2169 HGNC: 3556 AceView: FABP2 Ensembl:ENSG00000145384 euGenes: HUgn2169
    ECgene: FABP2 Kegg: 2169 H-InvDB: FABP2

    Other Databases showing FABP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FABP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FABP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FABP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FABP2 gene:
    Search GeneIP for patents involving FABP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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