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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FABP12 Gene

protein-coding   GIFtS: 40
GCID: GC08M082437

Fatty Acid Binding Protein 12

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fatty Acid Binding Protein 121 2
Fatty Acid Binding Protein ORF2
Fatty Acid-Binding Protein 122
Intracellular Fatty Acid-Binding Protein FABP122
Probable Fatty Acid-Binding Protein ENSP000003536502

External Ids:    HGNC: 345241   Entrez Gene: 6464862   Ensembl: ENSG000001974167   UniProtKB: A6NFH53   

Export aliases for FABP12 gene to outside databases

Previous GC identifers: GC08M082602 GC08M077927


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FABP12 Gene: 
FABP12 (fatty acid binding protein 12) is a protein-coding gene. Diseases associated with FABP12 include bladder squamous cell carcinoma, and schistosomiasis. GO annotations related to this gene include lipid binding and transporter activity. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
Function: May play a role in lipid transport (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FABP12 gene promoter:
         c-Fos   LHX3b/Lhx3b   AP-1   LHX3a/Lhx3a   c-Jun   ATF6   C/EBPalpha   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FABP12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

FABP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP12 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082437:  view genomic region     (about GC identifiers)

Start:
82,437,216 bp from pter      End:
82,443,613 bp from pter
Size:
6,398 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 (See protein sequence)
Recommended Name: Fatty acid-binding protein 12  
Size: 140 amino acids; 15565 Da
Developmental stage: Not detected in fetal tissues
Secondary accessions: B7SUN0

Explore the universe of human proteins at neXtProt for FABP12: NX_A6NFH5

Explore proteomics data for FABP12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NFH5

  • FABP12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FABP12 Protein Expression
    REFSEQ proteins: NP_001098751.1  
    ENSEMBL proteins: 
     ENSP00000427973   ENSP00000353650  

    Human Recombinant Protein Products for FABP12: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FABP: Fatty acid binding protein family

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry A6NFH5

    ProtoNet protein and cluster: A6NFH5

    UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    FABP12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBP12_HUMAN, A6NFH5
    Function: May play a role in lipid transport (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0008289lipid binding IEA--
         
    FABP12 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FABP12

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FABP12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FABP12 (FBP12)

    10/46 Novoseek inferred chemical compound relationships for FABP12 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 88.4 407 16148539 (5), 1488044 (4), 9787106 (3), 12387845 (3) (see all 99)
    n-palmitoylphosphatidylethanolamine 81 1 1488044 (1)
    oleic acid 64.4 3 7896310 (1), 1764049 (1), 7578949 (1)
    acrylodan 59.2 1 8626681 (1)
    lipid 56.8 37 16148539 (2), 17413119 (1), 18296488 (1), 1743378 (1) (see all 26)
    triacylglycerol 53.4 1 10629058 (1)
    palmitate 53.2 5 1649054 (1), 19118410 (1), 12001232 (1), 1397504 (1) (see all 5)
    15-hydroxyeicosatetraenoic acid 52.3 1 2116490 (1)
    acyl-coa 44.6 4 8387630 (1), 10412765 (1), 8882970 (1), 1780038 (1)
    mk 886 43.4 2 11389700 (1), 10333477 (1)

    Search CenterWatch for drugs/clinical trials and news about FABP12 / FBP12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FABP12 gene: 
    NM_001105281.1  

    Unigene Cluster for FABP12:

    Fatty acid binding protein 12
    Hs.586370  [show with all ESTs]
    Unigene Representative Sequence: AI651519
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519696(uc003ycg.4) ENST00000360464(uc011lfp.2)

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FABP12

    Additional mRNA sequence: 

    BC146973.1 BC146981.1 EU733650.1 

    2 DOTS entries:

    DT.305601  DT.95092046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FABP12 expression in normal human tissues (normalized intensities)      FABP12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FABP12 Expression
    About this image


    FABP12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina
             retina   
     
     Testis (Reproductive System)

    See FABP12 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.586370

    UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
    Tissue specificity: Expressed in a number of retinoblastoma cell lines

        SABiosciences Custom PCR Arrays for FABP12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FABP12 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fabp121 , 5 fatty acid binding protein 121, 5 84.6(n)1
    80.3(a)1
      3 (2.57 cM)5
    754971  NM_029310.11  NP_083586.11 
     102442095 
    chicken
    (Gallus gallus)
    Aves FABP46
    fatty acid-binding protein, adipocyte
    61(a)
    possible ortholog
    2(121225723-121228944)
    lizard
    (Anolis carolinensis)
    Reptilia FABP96
    Uncharacterized protein
    48(a)
    possible ortholog
    4(24482953-24493834)
    zebrafish
    (Danio rerio)
    Actinopterygii fabp11b6
    CABZ01088982.16
    (see all 4)
    Uncharacterized protein
    (see all 4)
    44(a)
    42(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    16(18199547-18202985)
    12(48259768-48260265)


    ENSEMBL Gene Tree for FABP12 (if available)
    TreeFam Gene Tree for FABP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FABP12 gene
    FABP52  RBP52  FABP92  CRABP22  FABP42  FABP32  RBP12  RBP22  
    CRABP12  FABP22  PMP22  FABP72  RBP72  
    15 SIMAP similar genes for FABP12 using alignment to 2 protein entries:     FBP12_HUMAN (see all proteins):
    FABP9    PMP2    FABP4    FABP3    DKFZp547J2313    FABP7
    FABP5    FABP5P3    CRABP2    CRABP1    RBP2    RBP5
    RBP7    FABP2    RBP1

    FABP12 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FABP12
    PGOHUM00000243414


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 SNPs in FABP12 are shown (see all 214)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466277661,2
    --82436947(+) AGGTGC/TGCTGT 1 -- ds50010--------
    rs1921981531,2
    --82436948(+) GGTGCA/GCTGTA 1 -- ds50010--------
    rs1809963381,2
    C--82436953(+) GCTGTA/GTTCTA 1 -- ds50010--------
    rs578894041,2
    C,F--82436972(+) AAAATA/CTTATT 1 -- ds50013Minor allele frequency- C:0.15WA NA 240
    rs1852790371,2
    --82437044(+) AAAAAG/TCAACA 1 -- ds50010--------
    rs106270971,2
    C--82437068(+) GAAAATAT/-TATCC 1 -- cds11Minor allele frequency- -:0.00CSA 2
    rs2009858041,2
    C--82437068(+) TGAAAA/TTATCC 1 -- ds50010--------
    rs345677111,2
    C--82437069(+) AAAAT-/TATATCCC 1 -- cds10--------
    rs1405275971,2
    C--82437083(+) TTGCA-/TTTGAA 1 -- ds50010--------
    rs754024501,2
    C,F--82437121(+) GCCGCG/AAATGC 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for FABP12 (82437216 - 82443613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FABP12:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6274CNV Insertion18451855
    nsv465721CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    20/39 diseases for FABP12 (see all 39):    About MalaCards
    bladder squamous cell carcinoma    schistosomiasis    fascioliasis    omenn syndrome
    bladder transitional cell carcinoma    transitional cell carcinoma    ischemic heart disease    acute myocardial infarction
    bipolar disorder    maturity-onset diabetes of the young    myocardial infarction    coronary heart disease
    papillary thyroid carcinoma    celiac disease    hepatoblastoma    parkinson's disease
    atherosclerosis    oral squamous cell carcinoma    insulin resistance    brain injury


    FABP12 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/32 Novoseek inferred disease relationships for FABP12 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 51.2 2 2186049 (1), 16148539 (1)
    carcinoma transitional cell bladder 41.2 1 15734831 (1)
    acute myocardial infarction 41.1 9 9127740 (3), 9581860 (2), 2040092 (1), 11326147 (1) (see all 6)
    schistosomiasis 40 2 10849370 (1), 15725385 (1)
    obesity 35.3 3 15684432 (1), 9893016 (1), 16148539 (1)
    insulin resistance 30.9 1 16148539 (1)
    atherosclerosis 14 6 16148539 (4), 15990589 (1), 18977052 (1)
    dyslipidemia 12.2 1 16945373 (1)
    myocardial infarction 4.97 7 9456094 (3), 11179265 (1), 9127740 (1), 8130020 (1) (see all 5)
    shock 4.61 5 17205608 (1), 18577612 (1), 15634648 (1), 17726021 (1) (see all 5)


    Export disorders for FABP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FABP12 gene, integrated from 9 sources (see all 308):
    (articles sorted by number of sources associating them with FABP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PubMed id 18786628)1, 2, 3 Liu R.Z.... Godbout R. (2008)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. GWAS meta-analysis and replication identifies three ne w susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (2013)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function. (PubMed id 9127740)9 Wodzig K.W....van Dieijen-Visser M.P. (1997)
    8. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. (PubMed id 16148539)9 Makowski L. and Hotamisligil G.S. (2005)
    9. Identification, isolation, and characterization of a 32-kDa fatty acid-binding protein missing from lymphocytes in humans with Bietti crystalline dystrophy (BCD). (PubMed id 9787106)9 Lee J....Chader G.J. (1998)
    10. Acylation of 1-palmitoyl-sn-glycerophosphocholine by chick brain microsomes is unaffected by fatty acid binding protein. (PubMed id 1488044)9 Sellner P.A. and Phillips A.R. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 646486 HGNC: 34524 Ensembl:ENSG00000197416 euGenes: HUgn646486 ECgene: FABP12
    H-InvDB: FABP12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FABP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FABP12 gene:
    Search GeneIP for patents involving FABP12

    GeneCards and IP:
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