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Aliases for FABP12 Gene

Aliases for FABP12 Gene

  • Fatty Acid Binding Protein 12 2 3

External Ids for FABP12 Gene

Previous GeneCards Identifiers for FABP12 Gene

  • GC08M082602
  • GC08M082437
  • GC08M077927

Summaries for FABP12 Gene

GeneCards Summary for FABP12 Gene

FABP12 (Fatty Acid Binding Protein 12) is a Protein Coding gene. Diseases associated with FABP12 include bladder squamous cell carcinoma and fascioliasis. GO annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for FABP12 Gene

  • May play a role in lipid transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP12 Gene

Genomics for FABP12 Gene

Regulatory Elements for FABP12 Gene

Genomic Location for FABP12 Gene

Start:
81,524,981 bp from pter
End:
81,533,827 bp from pter
Size:
8,847 bases
Orientation:
Minus strand

Genomic View for FABP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP12 Gene

Proteins for FABP12 Gene

  • Protein details for FABP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFH5-FBP12_HUMAN
    Recommended name:
    Fatty acid-binding protein 12
    Protein Accession:
    A6NFH5
    Secondary Accessions:
    • B7SUN0

    Protein attributes for FABP12 Gene

    Size:
    140 amino acids
    Molecular mass:
    15565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FABP12 Gene

Proteomics data for FABP12 Gene at MOPED

Post-translational modifications for FABP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP12 Gene

Domains for FABP12 Gene

Gene Families for FABP12 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Protein Domains for FABP12 Gene

Suggested Antigen Peptide Sequences for FABP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFH5

UniProtKB/Swiss-Prot:

FBP12_HUMAN :
  • A6NFH5
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP12: view

Function for FABP12 Gene

Molecular function for FABP12 Gene

UniProtKB/Swiss-Prot Function: May play a role in lipid transport.

Gene Ontology (GO) - Molecular Function for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP12: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FABP12 Gene

Localization for FABP12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP12 Gene COMPARTMENTS Subcellular localization image for FABP12 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FABP12 Gene

Pathways for FABP12 Gene

SuperPathways for FABP12 Gene

No Data Available

Interacting Proteins for FABP12 Gene

Gene Ontology (GO) - Biological Process for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0019433 triglyceride catabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FABP12: view

No data available for Pathways by source for FABP12 Gene

Compounds for FABP12 Gene

(46) Novoseek inferred chemical compound relationships for FABP12 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 88.4 152
n-palmitoylphosphatidylethanolamine 81 1
oleic acid 64.4 3
acrylodan 59.2 1
lipid 56.8 27
genes like me logo Genes that share compounds with FABP12: view

Transcripts for FABP12 Gene

mRNA/cDNA for FABP12 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FABP12 Gene

Fatty acid binding protein 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FABP12 Gene

No ASD Table

Relevant External Links for FABP12 Gene

GeneLoc Exon Structure for
FABP12
ECgene alternative splicing isoforms for
FABP12

Expression for FABP12 Gene

mRNA expression in normal human tissues for FABP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP12 Gene

This gene is overexpressed in Testis (23.8), Esophagus - Mucosa (10.1), Vagina (7.9), and Cervix - Ectocervix (4.9).

SOURCE GeneReport for Unigene cluster for FABP12 Gene Hs.586370

mRNA Expression by UniProt/SwissProt for FABP12 Gene

A6NFH5-FBP12_HUMAN
Tissue specificity: Expressed in a number of retinoblastoma cell lines.
genes like me logo Genes that share expressions with FABP12: view

No data available for Protein expression for FABP12 Gene

Orthologs for FABP12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FABP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP12 35
  • 99.52 (n)
  • 98.57 (a)
FABP12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP12 35
  • 85.95 (n)
  • 80.71 (a)
FABP12 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP12 35
  • 86.67 (n)
  • 82.86 (a)
FABP12 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp12 35
  • 84.73 (n)
  • 80.15 (a)
Fabp12 16
Fabp12 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FABP12 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp12 35
  • 82.19 (n)
  • 80.15 (a)
Species with no ortholog for FABP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FABP12 Gene

ENSEMBL:
Gene Tree for FABP12 (if available)
TreeFam:
Gene Tree for FABP12 (if available)

Paralogs for FABP12 Gene

Paralogs for FABP12 Gene

Selected SIMAP similar genes for FABP12 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FABP12 Gene

genes like me logo Genes that share paralogs with FABP12: view

Variants for FABP12 Gene

Sequence variations from dbSNP and Humsavar for FABP12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2046495 -- 81,533,009(-) TCGAC(A/G)TTTTC upstream-variant-2KB, intron-variant
rs2062446 -- 81,532,410(-) GACTA(C/T)TGGCC upstream-variant-2KB, intron-variant
rs3842190 -- 81,529,297(+) CACAT(-/G)TGACA intron-variant
rs4144766 -- 81,526,808(-) AATAT(C/T)ATGCA intron-variant
rs6473283 -- 81,531,936(+) TTACA(A/C)ACACA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FABP12 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV Gain 19166990
nsv6274 CNV Insertion 18451855

Relevant External Links for FABP12 Gene

HapMap Linkage Disequilibrium report
FABP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP12 Gene

Disorders for FABP12 Gene

(32) Novoseek inferred disease relationships for FABP12 Gene

Disease -log(P) Hits PubMed IDs
fatty liver 51.2 2
carcinoma transitional cell bladder 41.2 1
acute myocardial infarction 41.1 9
schistosomiasis 40 2
obesity 35.3 3
genes like me logo Genes that share disorders with FABP12: view

No data available for UniProtKB/Swiss-Prot for FABP12 Gene

Publications for FABP12 Gene

  1. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PMID: 18786628) Liu R.Z. … Godbout R. (Genomics 2008) 2 3 4
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  4. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for FABP12 Gene

Sources for FABP12 Gene

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