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FABP12 Gene

protein-coding   GIFtS: 39
GCID: GC08M082437

Fatty Acid Binding Protein 12

  See FABP12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Binding Protein 121 2
Fatty Acid Binding Protein ORF2
Fatty Acid-Binding Protein 122
Intracellular Fatty Acid-Binding Protein FABP122
Probable Fatty Acid-Binding Protein ENSP000003536502

External Ids:    HGNC: 345241   Entrez Gene: 6464862   Ensembl: ENSG000001974167   UniProtKB: A6NFH53   

Export aliases for FABP12 gene to outside databases

Previous GC identifers: GC08M082602 GC08M077927


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FABP12 Gene:
FABP12 (fatty acid binding protein 12) is a protein-coding gene. Diseases associated with FABP12 include bladder squamous cell carcinoma, and fascioliasis. GO annotations related to this gene include lipid binding and transporter activity. An important paralog of this gene is FABP5.

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
Function: May play a role in lipid transport (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FABP12 gene promoter:
         c-Fos   LHX3b/Lhx3b   AP-1   LHX3a/Lhx3a   c-Jun   ATF6   C/EBPalpha   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FABP12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FABP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

FABP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP12 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082437:  view genomic region     (about GC identifiers)

Start:
82,437,216 bp from pter      End:
82,443,613 bp from pter
Size:
6,398 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 (See protein sequence)
Recommended Name: Fatty acid-binding protein 12  
Size: 140 amino acids; 15565 Da
Developmental stage: Not detected in fetal tissues
Secondary accessions: B7SUN0

Explore the universe of human proteins at neXtProt for FABP12: NX_A6NFH5

Explore proteomics data for FABP12 at MOPED


See FABP12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001098751.1  
ENSEMBL proteins: 
 ENSP00000427973   ENSP00000353650  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FABP: Fatty acid binding protein family

4 InterPro protein domains:
 IPR012674 Calycin
 IPR011038 Calycin-like
 IPR000463 Fatty_acid-bd
 IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry A6NFH5

ProtoNet protein and cluster: A6NFH5

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


Find genes that share domains with FABP12           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FBP12_HUMAN, A6NFH5
Function: May play a role in lipid transport (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
GO:0008289lipid binding IEA--
     
Find genes that share ontologies with FABP12           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FABP12

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
extracellular1
mitochondrion1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FABP12
Interactions:

    Search GeneGlobe Interaction Network for FABP12

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for FABP12 (FBP12)

Selected Novoseek inferred chemical compound relationships for FABP12 gene (see all 46)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid 88.4 407 16148539 (5), 1488044 (4), 9787106 (3), 12387845 (3) (see all 99)
n-palmitoylphosphatidylethanolamine 81 1 1488044 (1)
oleic acid 64.4 3 7896310 (1), 1764049 (1), 7578949 (1)
acrylodan 59.2 1 8626681 (1)
lipid 56.8 37 16148539 (2), 17413119 (1), 18296488 (1), 1743378 (1) (see all 26)
triacylglycerol 53.4 1 10629058 (1)
palmitate 53.2 5 1649054 (1), 19118410 (1), 12001232 (1), 1397504 (1) (see all 5)
15-hydroxyeicosatetraenoic acid 52.3 1 2116490 (1)
acyl-coa 44.6 4 8387630 (1), 10412765 (1), 8882970 (1), 1780038 (1)
mk 886 43.4 2 11389700 (1), 10333477 (1)



Find genes that share compounds with FABP12           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FABP12 gene: 
NM_001105281.1  

Unigene Cluster for FABP12:

Fatty acid binding protein 12
Hs.586370  [show with all ESTs]
Unigene Representative Sequence: AI651519
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000519696(uc003ycg.4) ENST00000360464(uc011lfp.2)
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Additional mRNA sequence: 

BC146973.1 BC146981.1 EU733650.1 

2 DOTS entries:

DT.305601  DT.95092046 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FABP12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FABP12 Expression
About this image


FABP12 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Mature Rod Cells Outer Nuclear Layer
         Retina
 
 Neurons
         Mature Rod Cells Outer Nuclear Layer
 
 Testis (Reproductive System)
FABP12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FABP12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.586370

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
Tissue specificity: Expressed in a number of retinoblastoma cell lines

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for FABP12 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fabp121 , 5 fatty acid binding protein 121, 5 84.73(n)1
80.15(a)1
  3 (2.57 cM)5
754971  NM_029310.11  NP_083586.11 
 102442095 


ENSEMBL Gene Tree for FABP12 (if available)
TreeFam Gene Tree for FABP12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FABP12 gene
FABP52  RBP52  FABP92  CRABP22  FABP42  FABP32  RBP12  RBP22  
CRABP12  FABP22  PMP22  FABP72  RBP72  
15 SIMAP similar genes for FABP12 using alignment to 2 protein entries:     FBP12_HUMAN (see all proteins):
FABP9    PMP2    FABP4    FABP3    DKFZp547J2313    FABP7
FABP5    FABP5P3    CRABP2    CRABP1    RBP2    RBP5
RBP7    FABP2    RBP1

Find genes that share paralogs with FABP12           About GenesLikeMe


1 Pseudogenes.org Pseudogene for FABP12
PGOHUM00000243414


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FABP12 (see all 214)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1466277661,2
--82436947(+) AGGTGC/TGCTGT 1 -- ds50010--------
rs1921981531,2
--82436948(+) GGTGCA/GCTGTA 1 -- ds50010--------
rs1809963381,2
C--82436953(+) GCTGTA/GTTCTA 1 -- ds50010--------
rs578894041,2
C,F--82436972(+) AAAATA/CTTATT 1 -- ds50013Minor allele frequency- C:0.15WA NA 240
rs1852790371,2
--82437044(+) AAAAAG/TCAACA 1 -- ds50010--------
rs106270971,2
C--82437068(+) GAAAATAT/-TATCC 1 -- cds11Minor allele frequency- -:0.00CSA 2
rs2009858041,2
C--82437068(+) TGAAAA/TTATCC 1 -- ds50010--------
rs345677111,2
C--82437069(+) AAAAT-/TATATCCC 1 -- cds10--------
rs1405275971,2
C--82437083(+) TTGCA-/TTTGAA 1 -- ds50010--------
rs754024501,2
C,F--82437121(+) GCCGCG/AAATGC 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120

HapMap Linkage Disequilibrium report for FABP12 (82437216 - 82443613 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for FABP12:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6274CNV Insertion18451855
nsv465721CNV Gain19166990

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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6 diseases for FABP12:    
About MalaCards
bladder squamous cell carcinoma    fascioliasis    acute myocardial infarction    myocardial infarction
obesity    schizophrenia


Find genes that share disorders with FABP12           About GenesLikeMe

Selected Novoseek inferred disease relationships for FABP12 gene (see all 32)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver 51.2 2 2186049 (1), 16148539 (1)
carcinoma transitional cell bladder 41.2 1 15734831 (1)
acute myocardial infarction 41.1 9 9127740 (3), 9581860 (2), 2040092 (1), 11326147 (1) (see all 6)
schistosomiasis 40 2 10849370 (1), 15725385 (1)
obesity 35.3 3 15684432 (1), 9893016 (1), 16148539 (1)
insulin resistance 30.9 1 16148539 (1)
atherosclerosis 14 6 16148539 (4), 15990589 (1), 18977052 (1)
dyslipidemia 12.2 1 16945373 (1)
myocardial infarction 4.97 7 9456094 (3), 11179265 (1), 9127740 (1), 8130020 (1) (see all 5)
shock 4.61 5 17205608 (1), 18577612 (1), 15634648 (1), 17726021 (1) (see all 5)


Export disorders for FABP12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FABP12 gene, integrated from 10 sources (see all 308):
(articles sorted by number of sources associating them with FABP12)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PubMed id 18786628)1, 2, 3 Liu R.Z.... Godbout R. (Genomics 2008)
  2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (Nature 2006)
  3. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function. (PubMed id 9127740)9 Wodzig K.W....van Dieijen-Visser M.P. (Eur J Clin Chem Clin Biochem 1997)
  8. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. (PubMed id 16148539)9 Makowski L. and Hotamisligil G.S. (Curr. Opin. Lipidol. 2005)
  9. Identification, isolation, and characterization of a 32-kDa fatty acid-binding protein missing from lymphocytes in humans with Bietti crystalline dystrophy (BCD). (PubMed id 9787106)9 Lee J....Chader G.J. (Mol. Genet. Metab. 1998)
  10. Acylation of 1-palmitoyl-sn-glycerophosphocholine by chick brain microsomes is unaffected by fatty acid binding protein. (PubMed id 1488044)9 Sellner P.A. and Phillips A.R. (Mol. Cell. Biochem. 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 646486 HGNC: 34524 Ensembl:ENSG00000197416 euGenes: HUgn646486 ECgene: FABP12
H-InvDB: FABP12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FABP12 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FABP12 gene:
Search GeneIP for patents involving FABP12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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