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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FABP12 Gene

protein-coding   GIFtS: 39
GCID: GC08M082437

fatty acid binding protein 12

 Explore 47 diseases affiliated with
FABP12 via our new
 Human Malady Compendium 
Biological research products
for FABP12
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fatty Acid Binding Protein 121 2
LOC6464861
Fatty Acid Binding Protein ORF2
Fatty Acid-Binding Protein 122
Intracellular Fatty Acid-Binding Protein FABP122
Probable Fatty Acid-Binding Protein ENSP000003536502

External Ids:    HGNC: 345241   Entrez Gene: 6464862   Ensembl: ENSG000001974167   UniProtKB: A6NFH53   

Export aliases for FABP12 gene to outside databases

Previous GC identifers: GC08M082602 GC08M077927


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
Function: May play a role in lipid transport (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FABP12 gene promoter:
         c-Fos   LHX3b/Lhx3b   AP-1   LHX3a/Lhx3a   c-Jun   ATF6   C/EBPalpha   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FABP12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

FABP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP12 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082437:  view genomic region     (about GC identifiers)

Start:
82,437,216 bp from pter      End:
82,443,613 bp from pter
Size:
6,398 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 (See protein sequence)
Recommended Name: Fatty acid-binding protein 12  
Size: 140 amino acids; 15565 Da
Developmental stage: Not detected in fetal tissues
Secondary accessions: B7SUN0

Explore the universe of human proteins at neXtProt for FABP12: NX_A6NFH5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NFH5

  • FABP12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001098751.1  
    ENSEMBL proteins: 
     ENSP00000427973   ENSP00000353650  

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    Uscn Proteins for FABP12


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FABP12 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR000463 Fatty_acid-bd
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry A6NFH5

    ProtoNet protein and cluster: A6NFH5

    UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
    Function: May play a role in lipid transport (By similarity)

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0008289lipid binding IEA--


    FABP12 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FABP12

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FABP12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FABP12
    10/46 Novoseek chemical compound relationships for FABP12 gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 88.4 407 16148539 (5), 1488044 (4), 9787106 (3), 12387845 (3) (see all 99)
    n-palmitoylphosphatidylethanolamine 81 1 1488044 (1)
    oleic acid 64.4 3 7896310 (1), 1764049 (1), 7578949 (1)
    acrylodan 59.2 1 8626681 (1)
    lipid 56.8 37 16148539 (2), 17413119 (1), 18296488 (1), 1743378 (1) (see all 26)
    triacylglycerol 53.4 1 10629058 (1)
    palmitate 53.2 5 1649054 (1), 19118410 (1), 12001232 (1), 1397504 (1) (see all 5)
    15-hydroxyeicosatetraenoic acid 52.3 1 2116490 (1)
    acyl-coa 44.6 4 8387630 (1), 10412765 (1), 8882970 (1), 1780038 (1)
    mk 886 43.4 2 11389700 (1), 10333477 (1)

    Search CenterWatch for drugs/clinical trials and news about FABP12 / FBP12 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FABP12 gene: 
    NM_001105281.1  

    Unigene Cluster for FABP12:

    Fatty acid binding protein 12
    Hs.586370  [show with all ESTs]
    Unigene Representative Sequence: AI651519
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519696(uc003ycg.4) ENST00000360464(uc011lfp.2)

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    Additional cDNA sequence: 

    BC146973.1 BC146981.1 EU733650.1 

    2 DOTS entries:

    DT.305601  DT.95092046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FABP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    FABP12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FABP12 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.586370

    UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5
    Tissue specificity: Expressed in a number of retinoblastoma cell lines

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FABP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FABP12 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia FABP46
    --
    57(a)
    1 ↔ 1
    4(24461711-24465632)
    zebrafish
    (Danio rerio)
    Actinopterygii fabp11b6
    fabp11a6
    (see all 4)
    fatty acid binding protein 11a
    (see all 4)
    44(a)
    41(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    16(18199547-18202985)
    19(33519855-33522332)
    fruit fly
    (Drosophila melanogaster)
    Insecta fabp6
    fatty acid bindin protein
    32(a)
    possible ortholog
    3R(7385612-7392771)
    worm
    (Caenorhabditis elegans)
    Secernentea lbp-66
    lbp-56
    (see all 5)
    Fatty acid-binding protein homolog 5
    (see all 5)
    39(a)
    35(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    I(6728286-6729379)
    I(6731270-6732281)


    ENSEMBL Gene Tree for FABP12 (if available)
    TreeFam Gene Tree for FABP12 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FABP12 gene
    FABP52  RBP52  FABP92  CRABP22  FABP42  RBP12  FABP32  CRABP12  
    RBP22  FABP22  PMP22  FABP72  RBP72  
    15 SIMAP similar genes for FABP12 using alignment to 2 protein entries:     FBP12_HUMAN (see all proteins):
    FABP9    PMP2    FABP4    FABP3    DKFZp547J2313    FABP7
    FABP5    FABP5P3    CRABP2    CRABP1    RBP2    RBP5
    RBP7    FABP2    RBP1

    FABP12 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FABP12
    PGOHUM00000243414


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/171 NCBI SNPs in FABP12 are shown (see all 171    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466277661,2
    --82436947(+) AGGTGC/TGCTGT 1 -- ds50010--------
    rs1921981531,2
    --82436948(+) GGTGCA/GCTGTA 1 -- ds50010--------
    rs1809963381,2
    C,--82436953(+) GCTGTA/GTTCTA 1 -- ds50010--------
    rs578894041,2
    C,--82436972(+) AAAATA/CTTATT 1 -- ds50013Minor allele frequency- C:0.15WA NA 240
    rs1852790371,2
    --82437044(+) AAAAAG/TCAACA 1 -- ds50010--------
    rs106270971,2
    C,--82437068(+) GAAAATAT/-TATCC 1 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs2009858041,2
    C--82437068(+) TGAAAA/TTATCC 1 -- ds50010--------
    rs602861001,2
    C--82437071(+) AATAT-/TATCCCAG 1 -- ds50010--------
    rs1405275971,2
    C,--82437083(+) TTGCA-/TTTGAA 1 -- ds50010--------
    rs754024501,2
    --82437121(+) GCCGCG/AAATGC 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for FABP12 (82437216 - 82443613 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FABP12: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FABP12 for disorders           About GeneDecksing

    20/47 diseases for FABP12 (see all 47):    About MalaCards
    retinol binding protein    maturity-onset diabetes of the young    myocardial infarction    acute myocardial infarction
    coronary heart disease    bladder transitional cell carcinoma    transitional cell carcinoma    squamous cell carcinoma
    insulin resistance    bladder squamous cell carcinoma    ischemic heart disease    atrial fibrillation
    oral squamous cell carcinoma    omenn syndrome    bipolar disorder    papillary thyroid carcinoma
    schistosomiasis    brain injury    neurodegenerative disease    fascioliasis

    10/32 Novoseek disease relationships for FABP12 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 51.2 2 2186049 (1), 16148539 (1)
    carcinoma transitional cell bladder 41.2 1 15734831 (1)
    acute myocardial infarction 41.1 9 9127740 (3), 9581860 (2), 2040092 (1), 11326147 (1) (see all 6)
    schistosomiasis 40 2 10849370 (1), 15725385 (1)
    obesity 35.3 3 15684432 (1), 9893016 (1), 16148539 (1)
    insulin resistance 30.9 1 16148539 (1)
    atherosclerosis 14 6 16148539 (4), 15990589 (1), 18977052 (1)
    dyslipidemia 12.2 1 16945373 (1)
    myocardial infarction 4.97 7 9456094 (3), 11179265 (1), 9127740 (1), 8130020 (1) (see all 5)
    shock 4.61 5 17205608 (1), 18577612 (1), 15634648 (1), 17726021 (1) (see all 5)


    Export disorders for FABP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FABP12 gene, integrated from 9 sources (see all 307):
    (articles sorted by number of sources associating them with FABP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PubMed id 18786628)1, 2, 3 Liu R.Z.... Godbout R. (2008)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function. (PubMed id 9127740)9 Wodzig K.W....van Dieijen-Visser M.P. (1997)
    7. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. (PubMed id 16148539)9 Makowski L. and Hotamisligil G.S. (2005)
    8. Identification, isolation, and characterization of a 32-kDa fatty acid-binding protein missing from lymphocytes in humans with Bietti crystalline dystrophy (BCD). (PubMed id 9787106)9 Lee J....Chader G.J. (1998)
    9. Acylation of 1-palmitoyl-sn-glycerophosphocholine by chick brain microsomes is unaffected by fatty acid binding protein. (PubMed id 1488044)9 Sellner P.A. and Phillips A.R. (1992)
    10. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. (PubMed id 1512466)9 Madsen P.S.... Celis J.E. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 646486 HGNC: 34524 Ensembl:ENSG00000197416 euGenes: HUgn646486 ECgene: FABP12
    H-InvDB: FABP12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FABP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FABP12 gene:
    Search GeneIP for patents involving FABP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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