FABP12 Gene
protein-coding GIFtS : 39
GCID: GC08 M082437
fatty acid binding protein 12
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Aliasesfor FABP12 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Fatty Acid Binding Protein 12 1 2 LOC6464861 Fatty Acid Binding Protein ORF2 Fatty Acid-Binding Protein 122 Intracellular Fatty Acid-Binding Protein FABP122 Probable Fatty Acid-Binding Protein ENSP000003536502
Export aliases for FABP12 gene to outside databases Previous GC identifers: GC08M082602 GC08M077927
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Summariesfor FABP12 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 Function : May play a role in lipid transport (By similarity)
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Genomic Viewsfor FABP12 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008183.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FABP12 gene promoter: c-Fos LHX3b/Lhx3b AP-1 LHX3a/Lhx3a c-Jun ATF6 C/EBPalpha Ik-1 Other transcription factors Search SABiosciences Chromatin IP Primers for FABP12 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP12
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q21.13 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.13 FABP12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M082437: view genomic region
(about GC identifiers )
Start:
82,437,216 bp from pter
End:
82,443,613 bp from pter
Size:
6,398 bases
Orientation:
minus strand
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Proteinsfor FABP12 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 (See
protein sequence )Recommended Name: Fatty acid-binding protein 12 Size : 140 amino acids; 15565 Da
Developmental stage : Not detected in fetal tissues
Secondary accessions : B7SUN0Explore the universe of human proteins at neXtProt for FABP12: NX_A6NFH5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A6NFH5 FABP12 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001098751.1 ENSEMBL proteins: ENSP00000427973 ENSP00000353650 Human Recombinant Protein Products: FABP12 Antibody Products: Assay Products for FABP12:
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Protein
Domains / Familiesfor FABP12 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FABP12 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry A6NFH5 ProtoNet protein and cluster: A6NFH5
UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 Similarity : Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family
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Functionfor FABP12 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 Function : May play a role in lipid transport (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FABP12 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FABP12OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FABP12 (NM_001105281 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FABP12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FABP12
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005215 transporter activity
IEA -- GO:0008289 lipid binding
IEA --
FABP12 for ontologies About GeneDecksing
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Pathways & Interactionsfor FABP12 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FABP12
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Drugs & Compoundsfor FABP12 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
FABP12 for compounds About GeneDecksing Browse Tocris compounds for FABP12 10/46 Novoseek chemical compound relationships for FABP12 gene (see all 46 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid
88.4
407
16148539 (5), 1488044 (4), 9787106 (3), 12387845 (3) (see all 99 )
n-palmitoylphosphatidylethanolamine
81
1
1488044 (1)
oleic acid
64.4
3
7896310 (1), 1764049 (1), 7578949 (1)
acrylodan
59.2
1
8626681 (1)
lipid
56.8
37
16148539 (2), 17413119 (1), 18296488 (1), 1743378 (1) (see all 26 )
triacylglycerol
53.4
1
10629058 (1)
palmitate
53.2
5
1649054 (1), 19118410 (1), 12001232 (1), 1397504 (1) (see all 5 )
15-hydroxyeicosatetraenoic acid
52.3
1
2116490 (1)
acyl-coa
44.6
4
8387630 (1), 10412765 (1), 8882970 (1), 1780038 (1)
mk 886
43.4
2
11389700 (1), 10333477 (1)
Search CenterWatch for drugs/clinical trials and news about FABP12 / FBP12
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Transcriptsfor FABP12 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FABP12 gene: NM_001105281.1 Unigene Cluster for FABP12:
Fatty acid binding protein 12 Hs.586370 [show with all ESTs ] Unigene Representative Sequence: AI651519 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000519696 (uc003ycg.4 ) ENST00000360464 (uc011lfp.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FABP12 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FABP12OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FABP12 (NM_001105281 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FABP12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FABP12
Additional cDNA sequence: BC146973.1 BC146981.1 EU733650.1
2 DOTS entries : DT.305601 DT.95092046
GeneLoc Exon Structure
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Expression for FABP12 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FABP12 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image FABP12 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Outer Nuclear Layer Mature Rod Cells Photoreceptors, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FABP12 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.586370 UniProtKB/Swiss-Prot: FBP12_HUMAN, A6NFH5 Tissue specificity : Expressed in a number of retinoblastoma cell lines SABiosciences Custom PCR Arrays for FABP12 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FABP12Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FABP12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FABP12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FABP12
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Orthologsfor FABP12 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FABP12 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for FABP12 (if available)TreeFam Gene Tree for FABP12 (if available)
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Paralogsfor FABP12 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FABP12 gene FABP5 2 RBP5 2 FABP9 2 CRABP2 2 FABP4 2 RBP1 2 FABP3 2 CRABP1 2 RBP2 2 FABP2 2 PMP2 2 FABP7 2 RBP7 2 15 SIMAP similar genes for FABP12 using alignment to 2 protein entries: FBP12_HUMAN (see all proteins ):FABP9 PMP2 FABP4 FABP3 DKFZp547J2313 FABP7 FABP5 FABP5P3 CRABP2 CRABP1 RBP2 RBP5 RBP7 FABP2 RBP1
FABP12 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for FABP12 PGOHUM00000243414
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Genomic Variantsfor FABP12 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FABP12 (82437216 - 82443613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FABP12: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FABP12
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Disorders
/ Diseasesfor FABP12 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FABP12 for disorders About GeneDecksing 20/47 diseases for FABP12 (see all 47 ): About MalaCards retinol binding protein maturity-onset diabetes of the young myocardial infarction acute myocardial infarction coronary heart disease bladder transitional cell carcinoma transitional cell carcinoma squamous cell carcinoma insulin resistance bladder squamous cell carcinoma ischemic heart disease atrial fibrillation oral squamous cell carcinoma omenn syndrome bipolar disorder papillary thyroid carcinoma schistosomiasis brain injury neurodegenerative disease fascioliasis 10/32 Novoseek disease relationships for FABP12 gene (see all 32 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver
51.2
2
2186049 (1), 16148539 (1)
carcinoma transitional cell bladder
41.2
1
15734831 (1)
acute myocardial infarction
41.1
9
9127740 (3), 9581860 (2), 2040092 (1), 11326147 (1) (see all 6 )
schistosomiasis
40
2
10849370 (1), 15725385 (1)
obesity
35.3
3
15684432 (1), 9893016 (1), 16148539 (1)
insulin resistance
30.9
1
16148539 (1)
atherosclerosis
14
6
16148539 (4), 15990589 (1), 18977052 (1)
dyslipidemia
12.2
1
16945373 (1)
myocardial infarction
4.97
7
9456094 (3), 11179265 (1), 9127740 (1), 8130020 (1) (see all 5 )
shock
4.61
5
17205608 (1), 18577612 (1), 15634648 (1), 17726021 (1) (see all 5 )
Export disorders for FABP12 gene to outside databases
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Publicationsfor FABP12 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FABP12 gene, integrated from 9 sources (see all 307 ): (articles sorted by number of sources associating them with FABP12) Utopia : connect your pdf to the dynamic world of online information
A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PubMed id 18786628) 1 , 2 , 3 Liu R.Z.... Godbout R. (2008) DNA sequence and analysis of human chromosome 8. (PubMed id 16421571) 1 , 2 Nusbaum C....Lander E.S. (2006) Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738) 1 Fox C.S....Borecki I.B. (2012) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function. (PubMed id 9127740) 9 Wodzig K.W....van Dieijen-Visser M.P. (1997) The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. (PubMed id 16148539) 9 Makowski L. and Hotamisligil G.S. (2005) Identification, isolation, and characterization of a 32-kDa fatty acid-binding protein missing from lymphocytes in humans with Bietti crystalline dystrophy (BCD). (PubMed id 9787106) 9 Lee J....Chader G.J. (1998) Acylation of 1-palmitoyl-sn-glycerophosphocholine by chick brain microsomes is unaffected by fatty acid binding protein. (PubMed id 1488044) 9 Sellner P.A. and Phillips A.R. (1992) Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. (PubMed id 1512466) 9 Madsen P.S.... Celis J.E. (1992)
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External Searches for FABP12 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FABP12 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FABP12 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FABP12 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FABP12 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FABP12 gene: Search GeneIP for patents involving FABP12 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FABP12 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FABP12 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FABP12 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FABP12 OriGene Protein Over-expression Lysate for FABP12 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FABP12 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FABP12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FABP12 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FABP12 OriGene Custom Protein Services for FABP12 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FABP12 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FABP12 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP12 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FABP12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FABP12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FABP12
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Recombinant Protein for FABP12
FABP12 Proteins, Antibodies, CLIAs, and ELISAs
ThermoFisher Antibodies for FABP12
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FABP12
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Aliases for FABP12
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Expression for FABP12
Function for FABP12
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Intellectual Property for FABP12
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