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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FABP1 Gene

protein-coding GIFtS: 67
GCID: GC02M088422

Fatty Acid Binding Protein 1, Liver

36 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Fatty Acid Binding Protein 1, Liver¹ ²
Fatty Acid-Binding Protein 1² ³
Liver-Type Fatty Acid-Binding Protein² ³
FABPL² ³
L-FABP² ³
Fatty Acid-Binding Protein, Liver²

External Ids:	HGNC: 3555¹	Entrez Gene: 2168²	Ensembl: ENSG00000163586⁷	OMIM: 134650⁵	UniProtKB: P07148³

Export aliases for FABP1 gene to outside databases

Previous GC identifers: GC02M087977 GC02M088715 GC02M088307 GC02M088324 GC02M088261 GC02M087344

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FABP1 Gene:

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of

small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands.

This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought

that FABPs roles include fatty acid uptake, transport, and metabolism. (provided by RefSeq, Mar 2011)

GeneCards Summary for FABP1 Gene:

FABP1 (fatty acid binding protein 1, liver) is a protein-coding gene. Diseases associated with FABP1 include focal glomerulosclerosis, and hepatocellular adenoma, and among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolic pathways. GO annotations related to this gene include drug binding and phospholipid binding. An important paralog of this gene is FABP6.

UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148

Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in

the cytoplasm. May be involved in intracellular lipid transport

Gene Wiki entry for FABP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.2 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FABP1 gene promoter:
GR GR-beta NF-kappaB HNF-4alpha1 PPAR-gamma1 STAT3 GR-alpha PPAR-gamma2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FABP1 promoter sequence

Search SABiosciences Chromatin IP Primers for FABP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FABP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11

FABP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M088422: view genomic region (about GC identifiers)

Start:	88,422,501 bp from pter	End:	88,427,650 bp from pter
Size:	5,150 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148 (See protein sequence)

Recommended Name: Fatty acid-binding protein, liver

Size: 127 amino acids; 14208 Da

Subcellular location: Cytoplasm

6/19 PDB 3D structures from and Proteopedia for FABP1 (see all 19):

2F73 (3D)

2L67 (3D)

2L68 (3D)

2LKK (3D)

2PY1 (3D)

3B2H (3D)

Explore the universe of human proteins at neXtProt for FABP1: NX_P07148

Explore proteomics data for FABP1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P07148

FABP1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001434.1

ENSEMBL proteins:

ENSP00000295834 ENSP00000377351

Reactome Protein details: P07148
Human Recombinant Protein Products for FABP1:

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005782	peroxisomal matrix	ISS	--
GO:0005829	cytosol	IEA	--

FABP1 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

FABP: Fatty acid binding protein family

4 InterPro protein domains:

IPR012674 Calycin

IPR011038 Calycin-like

IPR000463 Fatty_acid-bd

IPR000566 Lipocln_cytosolic_FA-bd_dom

Graphical View of Domain Structure for InterPro Entry P07148

ProtoNet protein and cluster: P07148

1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148

Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior

Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

FABP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FABPL_HUMAN, P07148

Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in

the cytoplasm. May be involved in intracellular lipid transport

Genatlas biochemistry entry for FABP1:

fatty acid binding protein 1,liver

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0005215	transporter activity	--	--
GO:0005324	long-chain fatty acid transporter activity	IEA	--
GO:0005504	fatty acid binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

FABP1 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fabp1):

homeostasis/metabolism

liver/biliary system

FABP1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Fabp1^tm1Bin for FABP1

inGenious Targeting Laboratory - Custom generated mouse model solutions for FABP1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FABP1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FABP1 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.74			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Metabolism

Metabolism

0.40

Metabolism of lipids and lipoproteins

0.34

Selenium Metabolism and Selenoproteins

Selenium Metabolism and Selenoproteins

PPAR signaling pathway

PPAR signaling pathway

Glucose / Energy Metabolism

Glucose / Energy Metabolism

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for FABP1

Glucose / Energy Metabolism

1 BioSystems Pathway for FABP1

Selenium Metabolism and Selenoproteins

5 Reactome Pathways for FABP1

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Metabolism
	PPARA Activates Gene Expression
	Fatty acid, triacylglycerol, and ketone body metabolism
	Metabolism of lipids and lipoproteins

2 Kegg Pathways (Kegg details for FABP1):

	PPAR signaling pathway
	Fat digestion and absorption

FABP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FABP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/15 Interacting proteins for FABP1 (P07148³ ENSP00000295834⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARA	Q07869³, ENSP00000262735⁴	I2D: score=2 STRING: ENSP00000262735
PPARG	P37231³, ENSP00000287820⁴	I2D: score=2 STRING: ENSP00000287820
GRB2	P62993³, ENSP00000339007⁴	I2D: score=2 STRING: ENSP00000339007
NR3C1	P04150³	I2D: score=1
SNTA1	Q13424³	I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0015909	long-chain fatty acid transport	--	--
GO:0032000	positive regulation of fatty acid beta-oxidation	IEA	--
GO:0043066	negative regulation of apoptotic process	IDA	16175609

FABP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FABP1 for compounds About GeneDecksing

EMD Millipore small molecules for FABP1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FABP1 (FABPL)

4 DrugBank Compounds for FABP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Butenoic Acid	--	107-93-7	carrier	--	17139284 17016423 10592235
Oleic Acid	--	112-80-1	carrier	--	17139284 17016423 10592235
S-Methylcysteine	--	1187-84-4	carrier	--	17139284 17016423 10592235
Cholic Acid	--	81-25-4	carrier	--	10592235

10/35 Novoseek inferred chemical compound relationships for FABP1 gene (see all 35) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid	83.6	287	10064902 (5), 15138477 (5), 1699834 (5), 8664328 (4) (see all 99)
oleoyl-coa	82.3	1	12479568 (1)
11-(dansylamino)undecanoic acid	77.9	2	8053904 (1)
etomoxir	54.6	1	7557264 (1)
8-oxo-dg	54.2	10	19481229 (2), 16772708 (1), 19666118 (1), 17954367 (1) (see all 8)
sterol	52.7	27	8609911 (7), 8895052 (2), 8431458 (2), 7547928 (1) (see all 8)
bezafibrate	52.5	10	18368030 (5), 10064902 (1), 15708366 (1)
oleic acid	52.1	11	10331654 (2), 8262919 (2), 7588781 (1), 11329616 (1) (see all 8)
lipid	52	43	17698986 (3), 8431458 (3), 8664328 (2), 15249972 (2) (see all 23)
acyl-coa	51.6	9	9395205 (1), 17627968 (1), 10428978 (1), 12213584 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about FABP1 / FABPL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FABP1 gene:

NM_001443.2

Unigene Cluster for FABP1:

Fatty acid binding protein 1, liver

Hs.380135 [show with all ESTs]

Unigene Representative Sequence: BX641099

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295834(uc002sst.2) ENST00000393750 ENST00000495375 ENST00000472846

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Additional mRNA sequence:

BC022287.1 BC032801.1 BX641099.1 CR542090.1 M10050.1 M10617.1

14 DOTS entries:

DT.87016483 DT.91936262 DT.416902 DT.100743022 DT.416905 DT.100810634 DT.102827676 DT.87001698

DT.91744663 DT.121034754 DT.416906 DT.95094646 DT.95273281 DT.99939343

24/119 AceView cDNA sequences (see all 119):

BC032801 AV681776 R29613 M10617 BM766943 CB154162 AV647214 BM768288

AL531613 T68121 AI742193 CR590669 AV655309 BM855492 AV647083 CR542090

NM_001443 AV661404 CR612744 T53220 AA099433 AV657326 T68233 M10050

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FABP1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5
SP1:							-				-				-		-
SP2:											-
SP3:							-				-
SP4:							-

ECgene alternative splicing isoforms for FABP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FABP1 expression in normal human tissues (normalized intensities) FABP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACATTGGGTG

About this image

FABP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Intestine (Gastrointestinal Tract) fully expand to see all 3 entries
small intestine ; glandular cells
small intestine

Colon (Gastrointestinal Tract) fully expand to see all 2 entries
rectum ; glandular cells

Endothelium (Cardiovascular System) fully expand to see all 2 entries
Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...

Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Kidney (Urinary System)
kidney ; cells in tubules

See FABP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FABP1

SOURCE GeneReport for Unigene cluster: Hs.380135

SABiosciences Expression via Pathway-Focused PCR Arrays including FABP1 (see all 6):

Fatty Acid Metabolism in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Hepatotoxicity in human mouse rat

Fatty Liver in human mouse rat

PPAR Targets in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FABP1 gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fabp1^{1 , 5}	fatty acid binding protein 1, liver^{1, 5}	85.3(n)¹ 84.25(a)¹		6 (32.14 cM)⁵ 14080¹ NM_017399.4¹ NP_059095.1¹ 71199827⁵
chicken (Gallus gallus)	Aves	FABP1¹	fatty acid binding protein 1, liver	73.49(n) 70.08(a)		374015 NM_204192.2 NP_989523.1
lizard (Anolis carolinensis)	Reptilia	FABP1⁶	Uncharacterized protein	63(a)	1 ↔ 1	6(59363519-59380260)
African clawed frog (Xenopus laevis)	Amphibia	AF068301.1²	--	70.59(n)		AF068301.1
zebrafish (Danio rerio)	Actinopterygii	Dr.19577²	Transcribed sequence with weak similarity to protein more	73.71(n)		BI846703.1
wheat (Triticum aestivum)	Liliopsida	CA607013.1²	--	73.13(n)		CA607013.1

ENSEMBL Gene Tree for FABP1 (if available)
TreeFam Gene Tree for FABP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FABP1 gene

FABP6²

2 SIMAP similar genes for FABP1 using alignment to 4 protein entries: FABPL_HUMAN (see all proteins):

FABP6 CRABP2

FABP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188234129^1,2		--	88422068(+)	`CTAAGA/CCCTTT`	1	--	ds500¹		0	--	--	--	--
rs151243623^1,2		--	88422085(+)	`CCTCCC/TACAGG`	1	--	ds500¹		0	--	--	--	--
rs75476901^1,2	C,F	--	88422119(+)	`AGTGTC/TGACCT`	1	--	ds500¹		1		NA	120
rs140446615^1,2		--	88422313(+)	`TCCTGC/TAGATC`	1	--	ds500¹		0	--	--	--	--
rs201069426^1,2		--	88422317(+)	`CAGAT-/CTAG CTAGC`	1	--	ds500¹		0	--	--	--	--
rs74495561^1,2	C,F	--	88422352(+)	`ACCTGG/TGTGTG`	1	--	ds500¹		3		CSA WA	123
rs2919867^1,2	C,F,O,H	--	88422412(+)	`GTGTGG/AATCAT`	1	--	ds500¹		20		NS EA NA WA	3976
rs145556105^1,2		--	88422427(+)	`ATTATC/TAACAT`	1	--	ds500¹		0	--	--	--	--
rs138027807^1,2	C,F	--	88422571(+)	`GACTTG/CTTTAA`	1	--	ut3¹		1		NA	4484
rs112023736^1,2	C	--	88422624(+)	`ATGGTA/CTGAAA`	1	--	spa¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FABP1 (88422501 - 88427650 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for FABP1: About this table

Variant ID	Type	Subtype	PubMed ID
dgv61n16	CNV	Deletion	17901297
nsv874581	CNV	Gain	21882294
nsv834289	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): FABP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 134650 OMIM disorders: --

20/36 diseases for FABP1 (see all 36): About MalaCards

focal glomerulosclerosis hepatocellular adenoma thin basement membrane nephropathy kidney cancer

ureteral obstruction proteinuria colonic polyps fatty liver disease

liver disease cerebral infarction kidney disease acute pancreatitis

polycystic kidney disease duodenitis colorectal cancer hepatocellular carcinoma

glomerulonephritis malaria obesity insulin resistance

FABP1 for disorders About GeneDecksing

10/26 Novoseek inferred disease relationships for FABP1 gene (see all 26) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver	90.7	200	15138477 (5), 1699834 (5), 2164578 (2), 1711781 (2) (see all 99)
renal disease	52.2	40	16490622 (6), 12707994 (3), 14749682 (3), 16860300 (3) (see all 16)
chronic glomerulonephritis	42.5	5	16118482 (1), 16234607 (1), 16249547 (1)
proteinuria	33.1	6	16118482 (2), 19666118 (2), 17954367 (1), 18855269 (1)
diabetic nephropathies	32.3	16	19390215 (3), 19912308 (2), 19481229 (2), 16249547 (2) (see all 5)
colorectal cancer	27.2	20	10518104 (7), 15138477 (3), 16489072 (1), 2127610 (1)
microalbuminuria	27.1	3	16236942 (1), 16506273 (1)
hepatocellular carcinoma	22.7	10	17425983 (2), 2164578 (1), 1699834 (1)
liver damage	22.1	3	15696188 (1), 12406996 (1)
malabsorption	21.1	2	17605029 (2)

Genetic Association Database (GAD): FABP1
Human Genome Epidemiology (HuGE) Navigator: FABP1 (14 documents)

Export disorders for FABP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FABP1 gene, integrated from 9 sources (see all 248):
(articles sorted by number of sources associating them with FABP1)

Utopia: connect your pdf to the dynamic
world of online information

A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. (PubMed id 17698986)^{1, 3, 4, 9} Weickert M.O....Mohlig M. (2007)
Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. (PubMed id 15249972)^{1, 4, 9} Brouillette C....Vohl M.C. (2004)
Plasma concentrations of apolipoprotein B are modulated by a gene--diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men. (PubMed id 15308127)^{1, 4, 9} Robitaille J....Vohl M.C. (2004)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)^{1, 4} Ban H.J....Park K.J. (2010)
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)^{1, 4} Lu Y....Boer J.M. (2008)
Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. (PubMed id 18506375)^{1, 4} Yamada Y....Nozawa Y. (2008)
Codon 54 polymorphism of the fatty acid binding protein (FABP) 2 gene is associated with increased cardiovascular risk in the dyslipidemic diabetic participants of the Veterans Affairs HDL intervention trial (VA-HIT). (PubMed id 16945373)^{1, 4} Georgopoulos A....Schaefer E.J. (2007)
L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women. (PubMed id 17485234)^{1, 4} Fisher E....Doring F. (2007)
Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth. (PubMed id 15547295)^{1, 4} Stan S....Levy E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2168	HGNC: 3555	AceView: FABP1	Ensembl:ENSG00000163586	euGenes: HUgn2168
ECgene: FABP1	Kegg: 2168	H-InvDB: FABP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FABP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FABP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FABP1 gene:
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GeneCards and IP:
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FABP1 Gene

Fatty Acid Binding Protein 1, Liver

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Fatty Liver
Microalbuminuria
RENAL DISEASE
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OBESITY
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LIVER DAMAGE
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FABP1 Gene

Fatty Acid Binding Protein 1, Liver

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