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Aliases for FABP1 Gene

Aliases for FABP1 Gene

  • Fatty Acid Binding Protein 1, Liver 2 3
  • Liver-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 1 3 4
  • L-FABP 3 4
  • FABPL 3 4
  • Fatty Acid-Binding Protein, Liver 3

External Ids for FABP1 Gene

Summaries for FABP1 Gene

Entrez Gene Summary for FABP1 Gene

  • This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

GeneCards Summary for FABP1 Gene

FABP1 (Fatty Acid Binding Protein 1, Liver) is a Protein Coding gene. Diseases associated with FABP1 include hepatocellular adenoma and kidney cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include chromatin binding and drug binding. An important paralog of this gene is FABP6.

UniProtKB/Swiss-Prot for FABP1 Gene

  • Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport

Gene Wiki entry for FABP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP1 Gene

Genomics for FABP1 Gene

Genomic Location for FABP1 Gene

Start:
88,122,982 bp from pter
End:
88,128,131 bp from pter
Size:
5,150 bases
Orientation:
Minus strand

Genomic View for FABP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FABP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP1 Gene

Regulatory Elements for FABP1 Gene

Proteins for FABP1 Gene

  • Protein details for FABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07148-FABPL_HUMAN
    Recommended name:
    Fatty acid-binding protein, liver
    Protein Accession:
    P07148
    Secondary Accessions:

    Protein attributes for FABP1 Gene

    Size:
    127 amino acids
    Molecular mass:
    14208 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP1 Gene

neXtProt entry for FABP1 Gene

Proteomics data for FABP1 Gene at MOPED

Post-translational modifications for FABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP1 Gene

Domains for FABP1 Gene

Gene Families for FABP1 Gene

HGNC:
  • FABP :Fatty acid binding protein family

Protein Domains for FABP1 Gene

UniProtKB/Swiss-Prot:

FABPL_HUMAN
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior:
    • P07148
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.:
    • P07148
genes like me logo Genes that share domains with FABP1: view

Function for FABP1 Gene

Molecular function for FABP1 Gene

GENATLAS Biochemistry: fatty acid binding protein 1,liver
UniProtKB/Swiss-Prot Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport

Gene Ontology (GO) - Molecular Function for FABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005215 transporter activity --
GO:0005324 long-chain fatty acid transporter activity IEA --
GO:0005504 fatty acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FABP1: view

Phenotypes for FABP1 Gene

genes like me logo Genes that share phenotypes with FABP1: view

Animal Models for FABP1 Gene

MGI Knock Outs for FABP1:

miRNA for FABP1 Gene

miRTarBase miRNAs that target FABP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FABP1 Gene

Localization for FABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FABP1 Gene COMPARTMENTS Subcellular localization image for FABP1 gene
Compartment Confidence
nucleus 4
peroxisome 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005782 peroxisomal matrix ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP1: view

Pathways for FABP1 Gene

genes like me logo Genes that share pathways with FABP1: view

Gene Ontology (GO) - Biological Process for FABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006810 transport --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0015909 long-chain fatty acid transport IEA --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP1: view

Compounds for FABP1 Gene

(4) Drugbank Compounds for FABP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Butenoic Acid
107-93-7 carrier
Cholic Acid
81-25-4 carrier
Oleic Acid
112-80-1 carrier
S-Methylcysteine
1187-84-4 carrier

(35) Novoseek inferred chemical compound relationships for FABP1 Gene

Compound -log(P) Hits PubMed IDs
fatty acid 83.6 157
oleoyl-coa 82.3 1
11-(dansylamino)undecanoic acid 77.9 1
etomoxir 54.6 1
8-oxo-dg 54.2 9

(1) PharmGKB related drug/compound annotations for FABP1 Gene

Drug/compound Annotation
fenofibrate CA
genes like me logo Genes that share compounds with FABP1: view

Transcripts for FABP1 Gene

mRNA/cDNA for FABP1 Gene

Unigene Clusters for FABP1 Gene

Fatty acid binding protein 1, liver:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FABP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for FABP1 Gene

GeneLoc Exon Structure for
FABP1
ECgene alternative splicing isoforms for
FABP1

Expression for FABP1 Gene

mRNA expression in normal human tissues for FABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP1 Gene

This gene is overexpressed in Liver (23.9), Colon - Transverse (19.3), and Small Intestine - Terminal Ileum (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FABP1 Gene

SOURCE GeneReport for Unigene cluster for FABP1 Gene Hs.380135

genes like me logo Genes that share expressions with FABP1: view

Orthologs for FABP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP1 36
  • 99.48 (n)
  • 100 (a)
FABP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FABP1 36
  • 86.09 (n)
  • 81.1 (a)
FABP1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP1 36
  • 90.81 (n)
  • 90.55 (a)
FABP1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fabp1 36
  • 85.3 (n)
  • 84.25 (a)
Fabp1 16
Fabp1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FABP1 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FABP1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp1 36
  • 85.3 (n)
  • 82.68 (a)
chicken
(Gallus gallus)
Aves FABP1 36
  • 73.49 (n)
  • 70.08 (a)
LFABP 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP1 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp1 36
  • 68.24 (n)
  • 69.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.139 36
zebrafish
(Danio rerio)
Actinopterygii Dr.19577 36
fabp1a 36
  • 67.2 (n)
  • 65.08 (a)
fabp1a 37
  • 64 (a)
OneToMany
fabp1b.1 37
  • 66 (a)
OneToMany
fabp1b.2 37
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4471 37
  • 35 (a)
OneToMany
Species with no ortholog for FABP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FABP1 Gene

ENSEMBL:
Gene Tree for FABP1 (if available)
TreeFam:
Gene Tree for FABP1 (if available)

Paralogs for FABP1 Gene

Paralogs for FABP1 Gene

Selected SIMAP similar genes for FABP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FABP1: view

Variants for FABP1 Gene

Sequence variations from dbSNP and Humsavar for FABP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1123605 -- 88,124,389(+) GGTTG(A/G)AGGGT intron-variant
rs1530273 -- 88,125,188(+) AGAGA(C/T)GACAG intron-variant
rs1545223 -- 88,123,991(+) CCCTG(A/G)GGCAG intron-variant
rs1545224 -- 88,124,297(+) AAAGG(A/G)TTAGT intron-variant
rs1545225 -- 88,124,345(+) TCAGT(A/T)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FABP1 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV Deletion 17901297
nsv874581 CNV Gain 21882294
nsv834289 CNV Gain 17160897

Relevant External Links for FABP1 Gene

HapMap Linkage Disequilibrium report
FABP1
Human Gene Mutation Database (HGMD)
FABP1

Disorders for FABP1 Gene

(26) Novoseek inferred disease relationships for FABP1 Gene

Disease -log(P) Hits PubMed IDs
fatty liver 90.7 139
renal disease 52.2 30
chronic glomerulonephritis 42.5 3
proteinuria 33.1 6
diabetic nephropathies 32.3 11

Relevant External Links for FABP1

Genetic Association Database (GAD)
FABP1
Human Genome Epidemiology (HuGE) Navigator
FABP1
genes like me logo Genes that share disorders with FABP1: view

No data available for UniProtKB/Swiss-Prot for FABP1 Gene

Publications for FABP1 Gene

  1. A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. (PMID: 17698986) Weickert M.O. … MAPhlig M. (Am. J. Physiol. Endocrinol. Metab. 2007) 2 3 23 49
  2. Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. (PMID: 15249972) Brouillette C. … Vohl M.C. (J. Hum. Genet. 2004) 3 23 49
  3. Plasma concentrations of apolipoprotein B are modulated by a gene--diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men. (PMID: 15308127) Robitaille J. … Vohl M.C. (Mol. Genet. Metab. 2004) 3 23 49
  4. L-FABP and I-FABP expression increase NBD-stearate uptake and cytoplasmic diffusion in L cells. (PMID: 9688651) Murphy E.J. (Am. J. Physiol. 1998) 3 23
  5. Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. (PMID: 14563446) Pelsers M.M.A.L. … Glatz J.F.C. (Clin. Biochem. 2003) 3 23

Products for FABP1 Gene

Sources for FABP1 Gene

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