Aliases for FABP1 Gene
Aliases for FABP1 Gene
External Ids for FABP1 Gene
- HGNC: 3555
- Entrez Gene: 2168
- Ensembl: ENSG00000163586
- OMIM: 134650
- UniProtKB: P07148
Previous GeneCards Identifiers for FABP1 Gene
- GC02M087977
- GC02M088715
- GC02M088307
- GC02M088324
- GC02M088261
- GC02M088422
- GC02M087344
Summaries for FABP1 Gene
-
This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]
GeneCards Summary for FABP1 Gene
FABP1 (Fatty Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with FABP1 include Hepatocellular Adenoma and Fatty Liver Disease. Among its related pathways are Lipoprotein metabolism and Fat digestion and absorption. Gene Ontology (GO) annotations related to this gene include chromatin binding and lipid binding. An important paralog of this gene is FABP6.
UniProtKB/Swiss-Prot for FABP1 Gene
-
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Additional gene information for FABP1 Gene
- Monarch Initiative
- Search for FABP1 at DataMed
- Search for FABP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP1 Gene
Genomics for FABP1 Gene
GeneHancer (GH) Regulatory Elements for FABP1 Gene
Promoters and enhancers for FABP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02I088125 | Promoter/Enhancer | 1.6 | EPDnew ENCODE dbSUPER | 586.1 | -0.9 | -855 | 6.7 | FOXA2 MLX ARID4B ZNF48 ETS1 YY1 PAF1 RXRA SP5 NFYC | FABP1 THNSL2 KRCC1 GC02P088146 | |
| GH02I088169 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 17.8 | -42.4 | -42377 | 1.7 | POLR2A ZBTB11 PRDM10 ZFX ZBTB26 GABPA | THNSL2 LOC101928347 FABP1 | |
| GH02I088144 | Enhancer | 0.9 | ENCODE dbSUPER | 20 | -17.5 | -17471 | 3 | ELF3 ARID4B MAX THRB RAD21 RARA YY1 TEAD3 HOMEZ GATAD2A | GC02P088146 THNSL2 FABP1 KRCC1 LOC101928347 | |
| GH02I088074 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 15.9 | +53.2 | 53167 | 1.4 | JUND POLR2A HLF CEBPA CEBPB CEBPG RAD21 ZNF7 | FABP1 THNSL2 SMYD1 MIR4780 | |
| GH02I088066 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 11.6 | +60.1 | 60100 | 3.6 | PKNOX1 L3MBTL2 MAFK | SMYD1 GC02M088051 FABP1 THNSL2 MIR4780 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FABP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FABP1 gene promoter:
Regulatory Element Products
Genomic Locations for FABP1 Gene
Genomic Locations for FABP1 Gene
- chr2:88,122,982-88,128,131
- (GRCh38/hg38)
- Size:
- 5,150 bases
- Orientation:
- Minus strand
- chr2:88,422,501-88,427,650
- (GRCh37/hg19)
Genomic View for FABP1 Gene
Genes around FABP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p11.2 by Ensembl
- 2p11.2 by Entrez Gene
- 2p11.2 by HGNC
FABP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FABP1 Gene
Proteins for FABP1 Gene
-
Protein details for FABP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07148-FABPL_HUMAN
- Recommended name:
- Fatty acid-binding protein, liver
- Protein Accession:
- P07148
Protein attributes for FABP1 Gene
- Size:
- 127 amino acids
- Molecular mass:
- 14208 Da
- Quaternary structure:
- No Data Available
Protein Expression for FABP1 Gene
Post-translational modifications for FABP1 Gene
No Post-translational modifications
Other Protein References for FABP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FABP1 (FABP1/L-FABP)
- Cell Signaling Technology (CST) Antibodies for FABP1 (FABP1)
-
Custom Antibody ServicesOriGene Antibodies for FABP1
- Novus Biologicals Antibodies for FABP1
-
Abcam antibodies for FABP1
-
Cloud-Clone Corp. Antibodies for FABP1
- Invitrogen Antibodies for FABP1
- antibodies-online: Search results for 197 available FABP1 Antibodies ranked by validation data
- Compare Top FABP1 Antibodies
-
Recommended
- 121 WB Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IA Antibody (anti-human)
- 41 WB Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 47 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 RIA Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex FABP1 antibody for FABP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FABP1
- Sino Biological Antibodies for FABP1
Protein Products
- R&D Systems Proteins and Enzymes for FABP1 (FABP1/L-FABP)
-
OriGene Purified Proteins for FABP1
- Search Origene for MassSpec and Protein Over-expression Lysates for FABP1
- Origene Custom Protein Services for FABP1
- Sino Biological Recombinant Proteins for FABP1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for FABP1
-
Cloud-Clone Corp. Proteins for FABP1
- GeneTex Proteins for FABP1
-
ProSci Proteins for FABP1
-
Abcam proteins for FABP1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FABP1 (FABP1/L-FABP)
- antibodies-online: Search results for 63 available FABP1 Elisa Kits ranked by validation data
- Compare Top FABP1 Elisa Kits
-
Recommended
- 3 Chicken ELISA Kits
- 4 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 1 Guinea Pig ELISA Kit
- 13 Human ELISA Kits
- 2 Monkey ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 16 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
-
Abcam assays for FABP1
No data available for DME Specific Peptides for FABP1 Gene
Domains & Families for FABP1 Gene
Gene Families for FABP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FABP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FABP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07148UniProtKB/Swiss-Prot:
FABPL_HUMAN :- Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
- Domain:
-
- Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
- Family:
-
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Function for FABP1 Gene
Molecular function for FABP1 Gene
- GENATLAS Biochemistry:
- fatty acid binding protein 1,liver
- UniProtKB/Swiss-Prot Function:
- Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005324 | long-chain fatty acid transporter activity | IEA | -- |
| GO:0005504 | fatty acid binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005543 | phospholipid binding | IEA | -- |
Phenotypes for FABP1 Gene
- MGI mutant phenotypes for FABP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FABP1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased caspase 3/7 activity
- Decreased HIV-1 infection
Animal Models for FABP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FABP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FABP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FABP1 gene
- Search ViGene Biosciences for FABP1
CRISPR Products
-
OriGene CRISPR knockouts for FABP1
- genomics-online: gRNA clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
- Applied Biological Materials CRISPR for FABP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FABP1
- GenScript: Design CRISPR guide RNA sequences for FABP1
miRNA for FABP1 Gene
- miRTarBase miRNAs that target FABP1
miRNA Products
- Search ViGene Biosciences for FABP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FABP1
- Browse OriGene Inhibitory RNA Products For FABP1
- genomics-online: shRNA clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FABP1 gene
Clone Products
- Sino Biological Human cDNA Clone for FABP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FABP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FABP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FABP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FABP1
-
ViGene Biosciences adenoviral particle packaged cDNA for FABP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FABP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FABP1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP1 Gene
Localization for FABP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FABP1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| peroxisome | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005782 | peroxisomal matrix | ISS,IEA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
Pathways & Interactions for FABP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Lipoprotein metabolism | ||
| 3 | Metabolism |
.37
|
|
| 4 | Fat digestion and absorption | ||
| 5 | PPAR signaling pathway | ||
Pathways by source for FABP1 Gene
1 Cell Signaling Technology pathway for FABP1 Gene
2 BioSystems pathways for FABP1 Gene
7 Reactome pathways for FABP1 Gene
2 KEGG pathways for FABP1 Gene
Interacting Proteins for FABP1 Gene
Selected Interacting proteins:
P07148-FABPL_HUMAN
ENSP00000295834
for FABP1 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0015909 | long-chain fatty acid transport | IEA | -- |
| GO:0019216 | regulation of lipid metabolic process | TAS | -- |
| GO:0019433 | triglyceride catabolic process | TAS | -- |
| GO:0032000 | positive regulation of fatty acid beta-oxidation | IEA | -- |
No data available for SIGNOR curated interactions for FABP1 Gene
Drugs & Compounds for FABP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fenofibrate | Approved | Pharma | 173 | |||
| oleic acid | Approved, Investigational, Vet_approved | Pharma | Full agonist, Agonist, Carrier | 0 | ||
| cholic acid | Approved | Pharma | Full agonist, Agonist, Carrier | 0 | ||
| Butenoic Acid | Experimental | Pharma | Carrier | 0 | ||
| Methylcysteine | Experimental | Pharma | Carrier | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FABP1 Gene
mRNA/cDNA for FABP1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (119) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FABP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FABP1
- genomics-online: gRNA clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
- Applied Biological Materials CRISPR for FABP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FABP1
- GenScript: Design CRISPR guide RNA sequences for FABP1
miRNA Products
- Search ViGene Biosciences for FABP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FABP1
- Browse OriGene Inhibitory RNA Products For FABP1
- genomics-online: shRNA clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FABP1 gene
Clone Products
- Sino Biological Human cDNA Clone for FABP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FABP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FABP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FABP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: | - |
Expression for FABP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for FABP1 Gene
This gene is overexpressed in Liver (x23.9), Colon - Transverse (x19.3), and Small Intestine - Terminal Ileum (x5.2).
This gene is overexpressed in Liver, secretome (21.8), Fetal Liver (13.1), Liver (12.4), and Colon (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FABP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FABP1 Gene:
FABP1SOURCE GeneReport for Unigene cluster for FABP1 Gene:
Hs.380135Evidence on tissue expression from TISSUES for FABP1 Gene
- Intestine(4.9)
- Liver(4.9)
- Kidney(4.8)
- Stomach(4.3)
- Urine(2.3)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for FABP1
-
OriGene qPCR primer pairs and template standards for FABP1
- genomics-online: primer clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP1 Gene
Orthologs for FABP1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FABP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FABP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FABP1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fabp1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fabp1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FABP1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FABP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FABP1 33 |
|
||
| LFABP 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FABP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fabp1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fabp1a 33 34 |
|
||
| fabp1b.1 34 |
|
OneToMany | |||
| fabp1b.2 34 |
|
OneToMany | |||
| Dr.19577 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.139 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4471 34 |
|
OneToMany |
- Species where no ortholog for FABP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FABP1 Gene
(2) SIMAP similar genes for FABP1 Gene using alignment to 4 proteins:
Variants for FABP1 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000074723 | -- | 88,124,280(-) | T/C | intron_variant | |
| rs1000878160 | -- | 88,126,006(-) | C/T | intron_variant | |
| rs1001112664 | -- | 88,128,486(-) | T/C | upstream_transcript_variant | |
| rs1001263833 | -- | 88,125,177(-) | C/A | intron_variant | |
| rs1002422621 | -- | 88,125,572(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv61n16 | CNV | deletion | 17901297 |
| dgv6947n54 | CNV | gain | 21841781 |
| nsv1072005 | CNV | deletion | 25765185 |
| nsv1130752 | CNV | deletion | 24896259 |
| nsv1148611 | CNV | deletion | 26484159 |
| nsv582383 | CNV | gain | 21841781 |
| nsv582384 | CNV | loss | 21841781 |
| nsv582386 | CNV | loss | 21841781 |
| nsv834289 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.86;
74.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FABP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP1 Gene
Disorders for FABP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular adenoma |
|
|
| fatty liver disease |
|
|
| chylomicron retention disease |
|
Search FABP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FABP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FABP1 Gene
Publications for FABP1 Gene
- A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. (PMID: 17698986) Weickert MO … Möhlig M (American journal of physiology. Endocrinology and metabolism 2007) 2 3 22 44 58
- Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. (PMID: 15249972) Brouillette C … Vohl MC (Journal of human genetics 2004) 3 22 44 58
- Human FABP1 T94A variant enhances cholesterol uptake. (PMID: 25732850) Huang H … Schroeder F (Biochimica et biophysica acta 2015) 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 44 58
Products for FABP1 Gene
- R&D Systems Antibodies for FABP1 (FABP1/L-FABP)
- R&D Systems Proteins and Enzymes for FABP1 (FABP1/L-FABP)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for FABP1 (FABP1/L-FABP)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FABP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FABP1
- Search Origene for MassSpec and Protein Over-expression Lysates for FABP1
- Origene Custom Protein Services for FABP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FABP1
- Browse OriGene Inhibitory RNA Products For FABP1
- OriGene qPCR primer pairs and template standards for FABP1
- OriGene qPCR primer pairs for FABP1
- OriGene CRISPR knockouts for FABP1
- OriGene ORF clones in human for FABP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FABP1
- GenScript: Next-day shipping of latest version cDNA ORF clones for FABP1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FABP1
- GenScript Custom Assay Services for FABP1
- GenScript Custom overexpressing Cell Line Services for FABP1
- GenScript: Design CRISPR guide RNA sequences for FABP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FABP1
- Cell Signaling Technology (CST) Antibodies for FABP1 (FABP1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for FABP1
- Sino Biological Recombinant Proteins for FABP1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for FABP1
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for FABP1
- Novus Biologicals proteins and lysates for FABP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FABP1
- Abcam proteins for FABP1
- Abcam assays for FABP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for FABP1
- Cloud-Clone Corp. Antibodies for FABP1
- Cloud-Clone Corp. Proteins for FABP1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for FABP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for FABP1
- VectorBuilder custom plasmid, inducible vectors for FABP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FABP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 197 available FABP1 Antibodies ranked by validation data
- Compare Top FABP1 Antibodies
- Recommended
- 121 WB Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IA Antibody (anti-human)
- 41 WB Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 47 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 RIA Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 63 available FABP1 Elisa Kits ranked by validation data
- Compare Top FABP1 Elisa Kits
- Recommended
- 3 Chicken ELISA Kits
- 4 Cow (Bovine) ELISA Kits
- 1 Dog (Canine) ELISA Kit
- 1 Guinea Pig ELISA Kit
- 13 Human ELISA Kits
- 2 Monkey ELISA Kits
- 10 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 16 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 46 available FABP1 Proteins ranked by validation data
- Compare Top FABP1 Proteins
- GeneTex FABP1 antibody for FABP1
- GeneTex Proteins for FABP1
- ViGene Biosciences adenoviral particle packaged cDNA for FABP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FABP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FABP1 gene
- Search ViGene Biosciences for FABP1
- Santa Cruz Biotechnology (SCBT) Antibodies for FABP1
- Search Santa Cruz Biotechnology (SCBT) for FABP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FABP1
- Horizon Cell Lines for FABP1
- genomics-online: cdna clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
- orf clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
- genomics-online: gRNA clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
- genomics-online: primer clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
- genomics-online: shRNA clones - Search results for 91 available FABP1 gene related products
- Overview of 91 available FABP1 gene related products
Sources for FABP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew