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Set Analyses:

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FABP1 Gene

protein-coding GIFtS: 67
GCID: GC02M088422

Fatty Acid Binding Protein 1, Liver

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Fatty Acid Binding Protein 1, Liver¹ ²
Fatty Acid-Binding Protein 1² ³
Liver-Type Fatty Acid-Binding Protein² ³
FABPL² ³
L-FABP² ³
Fatty Acid-Binding Protein, Liver²

External Ids:	HGNC: 3555¹	Entrez Gene: 2168²	Ensembl: ENSG00000163586⁷	OMIM: 134650⁵	UniProtKB: P07148³

Export aliases for FABP1 gene to outside databases

Previous GC identifers: GC02M087977 GC02M088715 GC02M088307 GC02M088324 GC02M088261 GC02M087344

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FABP1 Gene:

This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of

small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands.

This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought

that FABPs roles include fatty acid uptake, transport, and metabolism. (provided by RefSeq, Mar 2011)

GeneCards Summary for FABP1 Gene:

FABP1 (fatty acid binding protein 1, liver) is a protein-coding gene. Diseases associated with FABP1 include focal glomerulosclerosis, and hepatocellular adenoma. GO annotations related to this gene include drug binding and chromatin binding. An important paralog of this gene is FABP6.

UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148

Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in

the cytoplasm. May be involved in intracellular lipid transport

Gene Wiki entry for FABP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NC_018913.2 NT_022184.16

Regulatory elements:

Regulatory transcription factor binding sites in the FABP1 gene promoter:
GR GR-beta NF-kappaB HNF-4alpha1 PPAR-gamma1 STAT3 GR-alpha PPAR-gamma2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FABP1 promoter sequence

Search Chromatin IP Primers for FABP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FABP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11

FABP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FABP1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M088422: view genomic region (about GC identifiers)

Start:	88,422,501 bp from pter	End:	88,427,650 bp from pter
Size:	5,150 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148 (See protein sequence)

Recommended Name: Fatty acid-binding protein, liver

Size: 127 amino acids; 14208 Da

Selected PDB 3D structures from and Proteopedia for FABP1 (see all 19):

2F73 (3D)

2L67 (3D)

2L68 (3D)

2LKK (3D)

2PY1 (3D)

3B2H (3D)

Explore the universe of human proteins at neXtProt for FABP1: NX_P07148

Explore proteomics data for FABP1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See FABP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001434.1

ENSEMBL proteins:

ENSP00000295834 ENSP00000377351

Reactome Protein details: P07148

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FABP1 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

FABP: Fatty acid binding protein family

3 InterPro protein domains:

IPR012674 Calycin

IPR011038 Calycin-like

IPR000463 Fatty_acid-bd

Graphical View of Domain Structure for InterPro Entry P07148

ProtoNet protein and cluster: P07148

1 Blocks protein domain: IPB000463 Cytosolic fatty-acid binding protein

UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148

Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior

Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

FABP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: FABPL_HUMAN, P07148

Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in

the cytoplasm. May be involved in intracellular lipid transport

Genatlas biochemistry entry for FABP1:

fatty acid binding protein 1,liver

Gene Ontology (GO): Selected molecular function terms (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003682	chromatin binding	IEA	--
GO:0005215	transporter activity	--	--
GO:0005324	long-chain fatty acid transporter activity	IEA	--
GO:0005504	fatty acid binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

FABP1 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fabp1):

homeostasis/metabolism

liver/biliary system

FABP1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Fabp1^tm1Bin for FABP1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FABP1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FABP1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FABP1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FABP1

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

FABPL_HUMAN, P07148: Cytoplasm

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
peroxisome	4
cytosol	3

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Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005782	peroxisomal matrix	ISS	--
GO:0005829	cytosol	IEA	--

FABP1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FABP1 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Fatty acid, triacylglycerol, and ketone body metabolism

	Fatty acid, triacylglycerol, and ketone body metabolism	0.65			PPARA Activates Gene Expression	0.63
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.65

Metabolism

Metabolism

0.38

Metabolism of lipids and lipoproteins

0.37

Selenium Metabolism and Selenoproteins

Selenium Metabolism and Selenoproteins

PPAR signaling pathway

PPAR signaling pathway

Glucose / Energy Metabolism

Glucose / Energy Metabolism

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for FABP1

Glucose / Energy Metabolism

1 BioSystems Pathway for FABP1

Selenium Metabolism and Selenoproteins

2 Reactome Pathways for FABP1

	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	PPARA activates gene expression

2 Kegg Pathways (Kegg details for FABP1):

	PPAR signaling pathway
	Fat digestion and absorption

FABP1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including FABP1 (see all 6):

Fatty Acid Metabolism in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Hepatotoxicity in human mouse rat

Fatty Liver in human mouse rat

PPAR Targets in human mouse rat

Interactions:

GeneGlobe Interaction Network for FABP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for FABP1 (P07148³ ENSP00000295834⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARA	Q07869³, ENSP00000262735⁴	I2D: score=2 STRING: ENSP00000262735
PPARG	P37231³, ENSP00000287820⁴	I2D: score=2 STRING: ENSP00000287820
GRB2	P62993³, ENSP00000339007⁴	I2D: score=2 STRING: ENSP00000339007
NR3C1	P04150³	I2D: score=1
SNTA1	Q13424³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0015909	long-chain fatty acid transport	--	--
GO:0032000	positive regulation of fatty acid beta-oxidation	IEA	--
GO:0043066	negative regulation of apoptotic process	IDA	16175609

FABP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for FABP1 (FABPL)

4 DrugBank Compounds for FABP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Butenoic Acid	--	107-93-7	carrier	--	17139284 17016423 10592235
Oleic Acid	--	112-80-1	carrier	--	17139284 17016423 10592235
S-Methylcysteine	--	1187-84-4	carrier	--	17139284 17016423 10592235
Cholic Acid	--	81-25-4	carrier	--	10592235

Selected Novoseek inferred chemical compound relationships for FABP1 gene (see all 35) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid	83.6	287	10064902 (5), 15138477 (5), 1699834 (5), 8664328 (4) (see all 99)
oleoyl-coa	82.3	1	12479568 (1)
11-(dansylamino)undecanoic acid	77.9	2	8053904 (1)
etomoxir	54.6	1	7557264 (1)
8-oxo-dg	54.2	10	19481229 (2), 16772708 (1), 19666118 (1), 17954367 (1) (see all 8)
sterol	52.7	27	8609911 (7), 8895052 (2), 8431458 (2), 7547928 (1) (see all 8)
bezafibrate	52.5	10	18368030 (5), 10064902 (1), 15708366 (1)
oleic acid	52.1	11	10331654 (2), 8262919 (2), 7588781 (1), 11329616 (1) (see all 8)
lipid	52	43	17698986 (3), 8431458 (3), 8664328 (2), 15249972 (2) (see all 23)
acyl-coa	51.6	9	9395205 (1), 17627968 (1), 10428978 (1), 12213584 (1) (see all 6)

FABP1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FABP1 gene:

NM_001443.2

Unigene Cluster for FABP1:

Fatty acid binding protein 1, liver

Hs.380135 [show with all ESTs]

Unigene Representative Sequence: BX641099

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295834(uc002sst.2) ENST00000393750 ENST00000495375 ENST00000472846

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Additional mRNA sequence:

BC022287.1 BC032801.1 BX641099.1 CR542090.1 M10050.1 M10617.1

14 DOTS entries:

DT.87016483 DT.91936262 DT.416902 DT.100743022 DT.416905 DT.100810634 DT.102827676 DT.87001698

DT.91744663 DT.121034754 DT.416906 DT.95094646 DT.95273281 DT.99939343

Selected AceView cDNA sequences (see all 119):

R29613 BC032801 AV647214 AL531613 CR612744 CB154162 NM_001443 BM766943

M10617 AV661404 T53220 AV655309 AA099433 CR542090 CR590669 AI742193

BM855492 BM768288 T68121 AV647083 AV681776 BI763102 BU602549 AA101894

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FABP1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5
SP1:							-				-				-		-
SP2:											-
SP3:							-				-
SP4:							-

ECgene alternative splicing isoforms for FABP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FABP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACATTGGGTG

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FABP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Liver (Hepatobiliary System) fully expand to see all 2 entries
Hepatocytes Liver Lobule
Hepatocyte-like cells

NULL (Uncategorized) fully expand to see all 2 entries
Vascular endothelial growth factor-induced embryoid bodies

Colon (Gastrointestinal Tract)

Kidney (Urinary System)

FABP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

FABP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.380135

Pathway & Disease-focused RT² Profiler PCR Arrays including FABP1 (see all 6):

Fatty Acid Metabolism in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Hepatotoxicity in human mouse rat

Fatty Liver in human mouse rat

PPAR Targets in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for FABP1 OriGene qSTAR qPCR primer pairs in human, mouse for FABP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat FABP1
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		QuantiFast Probe-based Assays in human, mouse, rat FABP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FABP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for FABP1 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fabp1^{1 , 5}	fatty acid binding protein 1, liver^{1, 5}	85.3(n)¹ 84.25(a)¹		6 (32.14 cM)⁵ 14080¹ NM_017399.4¹ NP_059095.1¹ 71199827⁵
chicken (Gallus gallus)	Aves	FABP1¹	fatty acid binding protein 1, liver	73.49(n) 70.08(a)		374015 NM_204192.3 NP_989523.1
lizard (Anolis carolinensis)	Reptilia	FABP1⁶	fatty acid binding protein 1, liver	65(a)	1 ↔ 1	6(59363519-59380260)
African clawed frog (Xenopus laevis)	Amphibia	AF068301.1²	--	70.59(n)		AF068301.1
zebrafish (Danio rerio)	Actinopterygii	Dr.19577²	Transcribed sequence with weak similarity to protein more	73.71(n)		BI846703.1
wheat (Triticum aestivum)	Liliopsida	CA607013.1²	--	73.13(n)		CA607013.1

ENSEMBL Gene Tree for FABP1 (if available)
TreeFam Gene Tree for FABP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for FABP1 gene

FABP6²

2 SIMAP similar genes for FABP1 using alignment to 4 protein entries: FABPL_HUMAN (see all proteins):

FABP6 CRABP2

FABP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188234129^1,2		--	88422068(+)	`CTAAGA/CCCTTT`	1	--	ds500¹		0	--	--	--	--
rs151243623^1,2		--	88422085(+)	`CCTCCC/TACAGG`	1	--	ds500¹		0	--	--	--	--
rs75476901^1,2	C,F	--	88422119(+)	`AGTGTC/TGACCT`	1	--	ds500¹		1		NA	120
rs140446615^1,2		--	88422313(+)	`TCCTGC/TAGATC`	1	--	ds500¹		0	--	--	--	--
rs201069426^1,2		--	88422317(+)	`CAGAT-/CTAG CTAGC`	1	--	ds500¹		0	--	--	--	--
rs74495561^1,2	C,F	--	88422352(+)	`ACCTGG/TGTGTG`	1	--	ds500¹		3		CSA WA	123
rs2919867^1,2	C,F,O,H	--	88422412(+)	`GTGTGG/AATCAT`	1	--	ds500¹		20		NS EA NA WA	3976
rs145556105^1,2		--	88422427(+)	`ATTATC/TAACAT`	1	--	ds500¹		0	--	--	--	--
rs138027807^1,2	C,F	--	88422571(+)	`GACTTG/CTTTAA`	1	--	ut3¹		1		NA	4484
rs112023736^1,2	C	--	88422624(+)	`ATGGTA/CTGAAA`	1	--	spa¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FABP1 (88422501 - 88427650 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for FABP1: About this table

Variant ID	Type	Subtype	PubMed ID
dgv61n16	CNV	Deletion	17901297
nsv874581	CNV	Gain	21882294
nsv834289	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): FABP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 134650 OMIM disorders: --

Selected diseases for FABP1 (see all 36):
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focal glomerulosclerosis hepatocellular adenoma thin basement membrane nephropathy ureteral obstruction

kidney cancer proteinuria diabetic nephropathy fatty liver disease

liver disease septic shock kidney disease acute pancreatitis

polycystic kidney disease glomerulonephritis duodenitis colorectal cancer

adenoma hepatocellular carcinoma obesity malaria

FABP1 for disorders About GeneDecksing

Selected Novoseek inferred disease relationships for FABP1 gene (see all 26) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver	90.7	200	15138477 (5), 1699834 (5), 2164578 (2), 1711781 (2) (see all 99)
renal disease	52.2	40	16490622 (6), 12707994 (3), 14749682 (3), 16860300 (3) (see all 16)
chronic glomerulonephritis	42.5	5	16118482 (1), 16234607 (1), 16249547 (1)
proteinuria	33.1	6	16118482 (2), 19666118 (2), 17954367 (1), 18855269 (1)
diabetic nephropathies	32.3	16	19390215 (3), 19912308 (2), 19481229 (2), 16249547 (2) (see all 5)
colorectal cancer	27.2	20	10518104 (7), 15138477 (3), 16489072 (1), 2127610 (1)
microalbuminuria	27.1	3	16236942 (1), 16506273 (1)
hepatocellular carcinoma	22.7	10	17425983 (2), 2164578 (1), 1699834 (1)
liver damage	22.1	3	15696188 (1), 12406996 (1)
malabsorption	21.1	2	17605029 (2)

Genetic Association Database (GAD): FABP1
Human Genome Epidemiology (HuGE) Navigator: FABP1 (14 documents)

Export disorders for FABP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FABP1 gene, integrated from 10 sources (see all 254):
(articles sorted by number of sources associating them with FABP1)

Utopia: connect your pdf to the dynamic
world of online information

A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. (PubMed id 17698986)^{1, 3, 4, 9} Weickert M.O....MAPhlig M. (Am. J. Physiol. Endocrinol. Metab. 2007)
Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. (PubMed id 15249972)^{1, 4, 9} Brouillette C....Vohl M.C. (J. Hum. Genet. 2004)
Plasma concentrations of apolipoprotein B are modulated by a gene--diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men. (PubMed id 15308127)^{1, 4, 9} Robitaille J....Vohl M.C. (Mol. Genet. Metab. 2004)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)^{1, 4} Ban H.J....Park K.J. (BMC Genet. 2010)
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)^{1, 4} Lu Y....Boer J.M. (J. Lipid Res. 2008)
Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. (PubMed id 18506375)^{1, 4} Yamada Y....Nozawa Y. (Int. J. Mol. Med. 2008)
Codon 54 polymorphism of the fatty acid binding protein (FABP) 2 gene is associated with increased cardiovascular risk in the dyslipidemic diabetic participants of the Veterans Affairs HDL intervention trial (VA-HIT). (PubMed id 16945373)^{1, 4} Georgopoulos A....Schaefer E.J. (Atherosclerosis 2007)
L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women. (PubMed id 17485234)^{1, 4} Fisher E....DAPring F. (Mol. Genet. Metab. 2007)
Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth. (PubMed id 15547295)^{1, 4} Stan S....Levy E. (J. Lipid Res. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2168	HGNC: 3555	AceView: FABP1	Ensembl:ENSG00000163586	euGenes: HUgn2168
ECgene: FABP1	Kegg: 2168	H-InvDB: FABP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FABP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FABP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for FABP1 gene:
Search GeneIP for patents involving FABP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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FABP1 Gene

Fatty Acid Binding Protein 1, Liver

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Fatty Liver
Microalbuminuria
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FABP1 Gene

Fatty Acid Binding Protein 1, Liver

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