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FABP1 Gene(Protein Coding)

Fatty Acid Binding Protein 1

GCID:
GC02M088122
GIFtS:
65
Genes Participants
UDN Logo

Aliases for FABP1 Gene

Aliases for FABP1 Gene

  • Fatty Acid Binding Protein 1 2 3 5
  • Liver-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid Binding Protein 1, Liver 2 3
  • L-FABP 3 4
  • FABPL 3 4
  • Fatty Acid-Binding Protein, Liver 3
  • Fatty Acid-Binding Protein 1 4

External Ids for FABP1 Gene

Previous GeneCards Identifiers for FABP1 Gene

  • GC02M087977
  • GC02M088715
  • GC02M088307
  • GC02M088324
  • GC02M088261
  • GC02M088422
  • GC02M087344

Summaries for FABP1 Gene

Entrez Gene Summary for FABP1 Gene

  • This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]

GeneCards Summary for FABP1 Gene

FABP1 (Fatty Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with FABP1 include Hepatocellular Adenoma and Chylomicron Retention Disease. Among its related pathways are Selenium Metabolism and Selenoproteins and Fat digestion and absorption. GO annotations related to this gene include chromatin binding and lipid binding. An important paralog of this gene is FABP6.

UniProtKB/Swiss-Prot for FABP1 Gene

  • Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).

Gene Wiki entry for FABP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP1 Gene

Genomics for FABP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FABP1 Gene

Enhancers for FABP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G088125 1.3 ENCODE dbSUPER 36.1 -0.9 -856 6.7 FOXA2 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 PAF1 ZNF202 SP5 FABP1 THNSL2 KRCC1 GC02P088146
GH02G088144 1 ENCODE dbSUPER 20 -17.5 -17471 3.0 ELF3 ARID4B MAX RBBP5 THRB RAD21 RARA YY1 TEAD3 HOMEZ THNSL2 FABP1 KRCC1 GC02P088146
GH02G088074 1.1 FANTOM5 Ensembl ENCODE 15.9 +53.2 53167 1.4 HLF CEBPB CEBPG ZBTB40 RAD21 ZNF7 JUND CEBPA FABP1 THNSL2 SMYD1 MIR4780
GH02G088160 1.2 ENCODE dbSUPER 11.1 -31.9 -31946 0.2 ELF3 WRNIP1 ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 SLC30A9 ZNF143 THNSL2 FABP1 GC02P088146
GH02G088066 1 Ensembl ENCODE 11.6 +60.1 60101 3.6 PKNOX1 IRF2 L3MBTL2 HCFC1 E2F5 BACH1 ZBTB40 ZNF83 YY1 FOSL1 FABP1 THNSL2 SMYD1 MIR4780
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FABP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FABP1 gene promoter:

Genomic Location for FABP1 Gene

Chromosome:
2
Start:
88,122,982 bp from pter
End:
88,128,131 bp from pter
Size:
5,150 bases
Orientation:
Minus strand

Genomic View for FABP1 Gene

Genes around FABP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FABP1 Gene

Proteins for FABP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FABP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07148-FABPL_HUMAN
    Recommended name:
    Fatty acid-binding protein, liver
    Protein Accession:
    P07148

    Protein attributes for FABP1 Gene

    Size:
    127 amino acids
    Molecular mass:
    14208 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP1 Gene

neXtProt entry for FABP1 Gene

Protein Expression for FABP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FABP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FABP1 (FABP1)

Assay Products

No data available for DME Specific Peptides for FABP1 Gene

Domains & Families for FABP1 Gene

Gene Families for FABP1 Gene

HGNC:

Protein Domains for FABP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FABP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07148

UniProtKB/Swiss-Prot:

FABPL_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP1: view

Function for FABP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FABP1 Gene

GENATLAS Biochemistry:
fatty acid binding protein 1,liver
UniProtKB/Swiss-Prot Function:
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).

Gene Ontology (GO) - Molecular Function for FABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005215 transporter activity IEA --
GO:0005324 long-chain fatty acid transporter activity IEA --
GO:0005504 fatty acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FABP1: view
genes like me logo Genes that share phenotypes with FABP1: view

Animal Models for FABP1 Gene

MGI Knock Outs for FABP1:

Animal Model Products

CRISPR Products

miRNA for FABP1 Gene

miRTarBase miRNAs that target FABP1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP1 Gene

Localization for FABP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP1 gene
Compartment Confidence
extracellular 5
peroxisome 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IEA --
GO:0005782 peroxisomal matrix IEA,ISS --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with FABP1: view

Pathways & Interactions for FABP1 Gene

genes like me logo Genes that share pathways with FABP1: view

Gene Ontology (GO) - Biological Process for FABP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0015909 long-chain fatty acid transport IEA --
GO:0019216 regulation of lipid metabolic process TAS --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP1: view

No data available for SIGNOR curated interactions for FABP1 Gene

Drugs & Compounds for FABP1 Gene

Products:

  1. Drug

(18) Drugs for FABP1 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fenofibrate Approved Pharma 170
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist, Carrier 0
cholic acid Approved Pharma Full agonist, Agonist, Carrier 0
Butenoic Acid Experimental Pharma Carrier 0
Methylcysteine Experimental Pharma Carrier 0

(20) Additional Compounds for FABP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FABP1: view

Transcripts for FABP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FABP1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(119) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FABP1 Gene

Fatty acid binding protein 1, liver:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for FABP1 Gene

GeneLoc Exon Structure for
FABP1
ECgene alternative splicing isoforms for
FABP1

Expression for FABP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FABP1 Gene

mRNA expression in normal human tissues for FABP1 Gene
mRNA expression by BioGPS for FABP1 GenemRNA expression by GTEx for FABP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP1 Gene

This gene is overexpressed in Liver (x23.9), Colon - Transverse (x19.3), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for FABP1 Gene

This gene is overexpressed in Liver, secretome (21.8), Fetal Liver (13.1), Liver (12.4), and Colon (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FABP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FABP1 Gene:

FABP1

SOURCE GeneReport for Unigene cluster for FABP1 Gene:

Hs.380135

Evidence on tissue expression from TISSUES for FABP1 Gene

  • Intestine(4.9)
  • Liver(4.9)
  • Kidney(4.8)
  • Stomach(4.3)
  • Urine(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with FABP1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP1 Gene

Orthologs for FABP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FABP1 34 35
  • 99.48 (n)
dog
(Canis familiaris)
 Mammalia FABP1 34 35
  • 90.81 (n)
cow
(Bos Taurus)
 Mammalia FABP1 34 35
  • 86.09 (n)
mouse
(Mus musculus)
 Mammalia Fabp1 34 16 35
  • 85.3 (n)
rat
(Rattus norvegicus)
 Mammalia Fabp1 34
  • 85.3 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia FABP1 35
  • 78 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia FABP1 35
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FABP1 34
  • 73.49 (n)
LFABP 35
  • 70 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FABP1 35
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fabp1 34
  • 68.24 (n)
zebrafish
(Danio rerio)
 Actinopterygii fabp1a 34 35
  • 67.2 (n)
fabp1b.1 35
  • 66 (a)
 OneToMany
fabp1b.2 35
  • 53 (a)
 OneToMany
Dr.19577 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.139 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4471 35
  • 35 (a)
 OneToMany
Species where no ortholog for FABP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FABP1 Gene

ENSEMBL:
Gene Tree for FABP1 (if available)
TreeFam:
Gene Tree for FABP1 (if available)

Paralogs for FABP1 Gene

Paralogs for FABP1 Gene

(2) SIMAP similar genes for FABP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FABP1: view

Variants for FABP1 Gene

Sequence variations from dbSNP and Humsavar for FABP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000074723 -- 88,124,280(+) TTGGT(C/T)GCGCT intron-variant
rs1000878160 -- 88,126,006(+) CTTCT(C/T)TATAA intron-variant
rs1001112664 -- 88,128,486(+) TTATA(C/T)ATGTC upstream-variant-2KB
rs1001263833 -- 88,125,177(+) TACAT(A/C)CTGGA intron-variant
rs1002422621 -- 88,125,572(+) GCCCA(A/G)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FABP1 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV deletion 17901297
dgv6947n54 CNV gain 21841781
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv582383 CNV gain 21841781
nsv582384 CNV loss 21841781
nsv582386 CNV loss 21841781
nsv834289 CNV gain 17160897

Variation tolerance for FABP1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.86; 74.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FABP1 Gene

Human Gene Mutation Database (HGMD)
FABP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP1 Gene

Disorders for FABP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FABP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular adenoma
chylomicron retention disease
  • anderson disease
- elite association - COSMIC cancer census association via MalaCards
Search FABP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FABP1

Genetic Association Database (GAD)
FABP1
Human Genome Epidemiology (HuGE) Navigator
FABP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FABP1
genes like me logo Genes that share disorders with FABP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP1 Gene

Publications for FABP1 Gene

  1. A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. (PMID: 17698986) Weickert M.O. … MAPhlig M. (Am. J. Physiol. Endocrinol. Metab. 2007) 2 3 22 46 64
  2. Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. (PMID: 15249972) Brouillette C. … Vohl M.C. (J. Hum. Genet. 2004) 3 22 46 64
  3. Human FABP1 T94A variant enhances cholesterol uptake. (PMID: 25732850) Huang H. … Schroeder F. (Biochim. Biophys. Acta 2015) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64

Products for FABP1 Gene

Sources for FABP1 Gene

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