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FAAH2 Gene

protein-coding   GIFtS: 53
GCID: GC0XP057330

Fatty Acid Amide Hydrolase 2

(Previous name: amidase domain containing)
(Previous symbol: AMDD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fatty Acid Amide Hydrolase 21 2     Anandamide Amidohydrolase 22 3
AMDD1 2 3     Oleamide Hydrolase 22 3
Amidase Domain Containing1 2     Fatty-Acid Amide Hydrolase 22
Amidase Domain-Containing Protein2 3     EC 3.5.1.993

External Ids:    HGNC: 264401   Entrez Gene: 1585842   Ensembl: ENSG000001655917   OMIM: 3006545   UniProtKB: Q6GMR73   

Export aliases for FAAH2 gene to outside databases

Previous GC identifer: GC0XP054375


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAAH2 Gene:
This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature
family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids,
including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides
and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.(provided by
RefSeq, Sep 2009)

GeneCards Summary for FAAH2 Gene:
FAAH2 (fatty acid amide hydrolase 2) is a protein-coding gene. Diseases associated with FAAH2 include glycogen storage disease ii, and glycogen storage disease. GO annotations related to this gene include hydrolase activity and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH.

UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7
Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic
amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates

summary for FAAH2 Gene:
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane
protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH
distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the
pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small
intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second
FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAAH2 gene promoter:
         AREB6   PPAR-alpha   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAAH2 promoter sequence
   Search Chromatin IP Primers for FAAH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAAH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11.1

FAAH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAAH2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP057330:  view genomic region     (about GC identifiers)

Start:
57,313,110 bp from pter      End:
57,515,629 bp from pter
Size:
202,520 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7 (See protein sequence)
Recommended Name: Fatty-acid amide hydrolase 2  
Size: 532 amino acids; 58304 Da
Subunit: Homodimer (By similarity)
Secondary accessions: Q86VT2 Q96N98

Explore the universe of human proteins at neXtProt for FAAH2: NX_Q6GMR7

Explore proteomics data for FAAH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAAH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_777572.2  
    ENSEMBL proteins: 
     ENSP00000364035  

    FAAH2 Human Recombinant Protein Products:

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    Novus Biologicals FAAH2 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for FAAH2

    FAAH2 Antibody Products:

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    ThermoFisher Antibody for FAAH2
    LSBio Antibodies in human, mouse, rat for FAAH2

    FAAH2 Assay Products:

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    Cloud-Clone Corp. ELISAs for FAAH2
    Cloud-Clone Corp. CLIAs for FAAH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid amide hydrolase-2
    Endocannabinoid turnover

    3 InterPro protein domains:
     IPR020556 Amidase_CS
     IPR000120 Amidase
     IPR023631 Amidase_dom

    Graphical View of Domain Structure for InterPro Entry Q6GMR7

    ProtoNet protein and cluster: Q6GMR7

    1 Blocks protein domain: IPB000120 Amidase

    UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7
    Similarity: Belongs to the amidase family


    FAAH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAAH2_HUMAN, Q6GMR7
    Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic
    amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
    Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates
    Catalytic activity: Anandamide + H(2)O = arachidonic acid + ethanolamine
    Catalytic activity: Oleamide + H(2)O = oleic acid + NH(3)
    Enzyme regulation: Inhibited by O-aryl carbamates and alpha-keto heterocytes

         Enzyme Number (IUBMB): EC 3.5.1.991

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
    GO:0016884carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA--
         
    FAAH2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAAH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAAH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAAH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAAH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAAH2:
    hsa-mir-335-5p (MIRT017603)

    Block miRNA regulation of human, mouse, rat FAAH2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAAH2
    SwitchGear 3'UTR luciferase reporter plasmidFAAH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAAH2
    Predesigned siRNA for gene silencing in human, mouse, rat FAAH2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FAAH2 (NM_174912)
    Sino Biological Human cDNA Clone for FAAH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAAH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FAAH2_HUMAN, Q6GMR7: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    FAAH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FAAH2 About    
    See pathways by source

    SuperPathContained pathways About
    1anandamide degradation
    anandamide degradation


    1 BioSystems Pathway for FAAH2
        anandamide degradation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAAH2
    Interactions:

        Search GeneGlobe Interaction Network for FAAH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for FAAH2 (ENSP000003640354) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEPDENSP000002441374STRING: ENSP00000244137
    STK16ENSP000003799644STRING: ENSP00000379964
    PET112ENSP000002639854STRING: ENSP00000263985
    BCKDHBENSP000003183514STRING: ENSP00000318351
    PDHBENSP000003072414STRING: ENSP00000307241
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for FAAH2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SA 57Potent FAAH inhibitor[1346169-63-8]
    PF 3845Selective FAAH inhibitor[1196109-52-0]
    JNJ 1661010 Selective, reversible FAAH inhibitor [681136-29-8]
    TC-F 2 Potent, reversible and selective FAAH inhibitor [1304778-15-1]

    1 HMDB Compound for FAAH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    AnandamideAnandamide (20.4, n-6) (see all 13)94421-68-8--

    2 IUPHAR Ligands for FAAH2 (Fatty acid amide hydrolase-2)    About this table
    LigandTypeActionAffinityPubmed IDs
    URB597
    InhibitorInhibition7.5 - 8.317015445
    OL135
    InhibitorInhibition7.917015445



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAAH2 gene: 
    NM_174912.3  

    Unigene Cluster for FAAH2:

    Fatty acid amide hydrolase 2
    Hs.496205  [show with all ESTs]
    Unigene Representative Sequence: NM_174912
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374900(uc004dvc.3) ENST00000491179 ENST00000465623
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAAH2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAAH2
    SwitchGear 3'UTR luciferase reporter plasmidFAAH2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAAH2
    Predesigned siRNA for gene silencing in human, mouse, rat FAAH2
    Clone
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    OriGene clones in human, mouse for FAAH2 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAAH2 (NM_174912)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAAH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAAH2
    OriGene qSTAR qPCR primer pairs in human, mouse for FAAH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FAAH2
      QuantiTect SYBR Green Assays in human, mouse, rat FAAH2
      QuantiFast Probe-based Assays in human, mouse, rat FAAH2

    Additional mRNA sequence: 

    AK055766.1 BC048279.1 BC073922.1 EU285560.1 

    3 DOTS entries:

    DT.101410  DT.95370388  DT.100755024 

    Selected AceView cDNA sequences (see all 40):

    BM714381 CA313962 AA370259 AI367190 AI811051 BC073922 W67536 BM675184 
    BE671210 BF448239 BX476543 NM_174912 AI248721 R02488 BI763065 BX487151 
    BC048279 CB306775 AA902127 BI769981 BX110322 AK055766 BM839438 BE504565 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAAH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGGATA
    FAAH2 Expression
    About this image

    FAAH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAAH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496205

    UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7
    Tissue specificity: Highly expressed in the brain, small intestine and testis. Also expressed in the heart,
    kidney, liver, lung and prostate

        Custom PCR Arrays for FAAH2
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    QuantiFast Probe-based Assays in human, mouse, rat FAAH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAAH2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    16(a)
    many ↔ many
    15(13994580-14006766)
    chicken
    (Gallus gallus)
    Aves FAAH21 fatty acid amide hydrolase 2 63.95(n)
    64.03(a)
      100859568  XM_003641132.2  XP_003641180.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAAH26
    fatty acid amide hydrolase 2
    56(a)
    1 ↔ 1
    GL343528.1(439337-466014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia faah21 fatty acid amide hydrolase 2 60.44(n)
    58.32(a)
      100488850  XM_002940405.2  XP_002940451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.168322 Transcribed sequence with weak similarity to protein more 73(n)    CF999295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88391 CG8839 52.9(n)
    47.51(a)
      36340  NM_136920.2  NP_610764.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y53F4B.181 CELE_Y53F4B.18 48.07(n)
    40.5(a)
      190217  NM_064702.1  NP_497103.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AMD26
    Putative amidase
    18(a)
    1 → many
    IV(946807-948456) YDR242W


    ENSEMBL Gene Tree for FAAH2 (if available)
    TreeFam Gene Tree for FAAH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAAH2 gene
    FAAH2  
    1 SIMAP similar gene for FAAH2 using alignment to 1 protein entry:     FAAH2_HUMAN:
    RP11-479E16.1

    FAAH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAAH2 (see all 3578)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835169111,2
    --57322738(+) TGGTCC/TAACTA 1 -- us2k10--------
    rs2010779121,2
    --57322773(+) ATTGT-/AAAAAA 1 -- us2k10--------
    rs1878501551,2
    --57322783(+) AAAAAA/CCAGAA 1 -- us2k10--------
    rs1929911161,2
    --57322843(+) TTATTA/CTACTT 1 -- us2k10--------
    rs1834660171,2
    --57322874(+) TAGGGA/GCATTA 1 -- us2k10--------
    rs1880171131,2
    --57322947(+) TCTGGA/TCAGAG 1 -- us2k10--------
    rs1928437161,2
    --57322952(+) TCAGAA/GCCCAA 1 -- us2k10--------
    rs1836899571,2
    --57322953(+) CAGAGC/TCCAAT 1 -- us2k10--------
    rs1867479471,2
    --57323146(+) TATCAC/GCTTTC 1 -- us2k10--------
    rs170028421,2
    C,F--57323172(+) AGATGT/CGCCTG 1 -- us2k13Minor allele frequency- C:0.01NA 142

    HapMap Linkage Disequilibrium report for FAAH2 (57313110 - 57515629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAAH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv514n21CNV Gain19592680

    Human Gene Mutation Database (HGMD): FAAH2
    Locus Specific Mutation Databases (LSDB): FAAH2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAAH2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAAH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300654    OMIM disorders: --

    5 diseases for FAAH2:    
    About MalaCards
    glycogen storage disease ii    glycogen storage disease    tuberculosis    prostatitis
    malaria


    FAAH2 for disorders           About GeneDecksing


    Export disorders for FAAH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAAH2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAAH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A second fatty acid amide hydrolase with variable distribution among placental mammals. (PubMed id 17015445)1, 2, 3 Wei B.Q.... Cravatt B.F. (J. Biol. Chem. 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. (PubMed id 19926788)1 Kaczocha M....Deutsch D.G. (J. Biol. Chem. 2010)
    5. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. (PubMed id 19095868)1 Karbarz M.J....Webb M. (Anesth. Analg. 2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158584 HGNC: 26440 AceView: FLJ31204 Ensembl:ENSG00000165591 euGenes: HUgn158584
    ECgene: FAAH2 H-InvDB: FAAH2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAAH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAAH2 gene:
    Search GeneIP for patents involving FAAH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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