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Aliases & Descriptions for FAAH2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AMDD 2, 3 | | EC 3.5.1.n2 3 | | FAAH-2 1, 2 | | FLJ31204 1, 2 | | OTTHUMP00000023420 2 | | RP11-479E16 2 | | RP11-479E16.1 1 |
| | | Descriptions |
|---|
| Amidase domain-containing protein 3 | | Anandamide amidohydrolase 2 3 | | Oleamide hydrolase 2 3 | | amidase domain containing 1, 2 | | fatty acid amide hydrolase 2 2 |
|
| | Search outside databases for aliases for FAAH2 gene |
Summaries for FAAH2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FAAH2: Fatty acid amide hydrolases, such as FAAH1 (FAAH; MIM 602935) and FAAH2, hydrolyze primary fatty acid amide substrates (e.g., oleamide) and may play a role in fatty acid catabolism (Wei et al., 2006 [PubMed 17015445]).[supplied by OMIM] UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates |
Genomic Location for FAAH2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.1 Ensembl cytogenetic band: Xp11.1 HGNC cytogenetic band: Xp11.1FAAH2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP057330:
(about GC identifiers)
Start:
|
57,329,864 bp from pter |
End:
|
57,532,351 bp from pter |
Size:
|
202,488 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011630.14
| Proteins for FAAH2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7 (See
protein sequence)Recommended Name: Fatty-acid amide hydrolase 2 Size: 532 amino acids; 58304 Da
Subunit: Homodimer (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q86VT2 Q96N98REFSEQ proteins: NP_777572.2
ENSEMBL proteins: ENSP00000364035
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for FAAH2: Assays for FAAH2: | Protein
Domains/ Families for FAAH2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6GMR7
ProtoNet protein and cluster: Q6GMR7 1 Blocks protein family: IPB000120 Amidase
UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7Similarity: Belongs to the amidase family | Gene Function for FAAH2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_174912
Applied Biosystems Silencer® siRNAs for FAAH2
Sigma-Aldrich siRNA and siRNA Panels for FAAH2  Sigma-Aldrich shRNA for FAAH2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_174912                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_174912                                  untagged cDNA clone in CMV expression vector: NM_174912 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_174912
UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substratesEnzyme regulation: Inhibited by O-aryl carbamates and alpha-keto heterocytesEnzyme Number (IUBMB): EC 3.5.1.n2 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
IEA | -- | About this table | Pathways & Interactions for FAAH2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for FAAH2 (ENSP000003640353) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for FAAH2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for FAAH2 available from Tocris Bioscience About this table
|
Transcripts for FAAH2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_174912
Sigma-Aldrich siRNA and siRNA Panels for FAAH2  Sigma-Aldrich shRNA for FAAH2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_174912 REFSEQ mRNAs for FAAH2 gene: NM_174912.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_174912               OriGene GFP tagged cDNA clone in CMV expression vector: NM_174912                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_174912                                  untagged cDNA clone in CMV expression vector: NM_174912  Additional cDNA sequence: AF086253.1 3 DOTS entries: DT.101410 DT.95370388 DT.100755024 24/40 AceView cDNA sequences (see all 40
):AA370259 BM714381 CA313962 AI367190 AI811051 W67536 BX487151 BE671210 R02488 AF086253 BF448239 BU685932 BI771343 BE504565 BI765011 BM675184 BX110322 BI769981 BX476543 BI763065 BC073922 NM_174912 AK055766 CB306775
highest scoring ESTs for FAAH2:AI248721 AI367190 AI457475 AI686695 AI811051 AK055766 BC048279 BF221899 BM675184 BM714381 Unigene Clusters for FAAH2: Fatty acid amide hydrolase 2 Hs.496205 [show with all ESTs], Hs.719735 Unigene Representative Sequences: NM_174912, AF086253
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000374900
|
Expression for FAAH2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FAAH2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FAAH2
1 / 2 / 3 3 probe-sets matching FAAH2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.496205 Hs.719735 UniProtKB/Swiss-Prot: FAAH2_HUMAN, Q6GMR7Tissue specificity: Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate |
Orthologs for FAAH2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FAAH2 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
zebrafish (Danio rerio) |
Dr.168322 |
-- |
Transcribed sequence with weak similarity to protein more |
73(n) |
CF999295.1 |
fruit fly (Drosophila melanogaster) |
CG88391 |
-- |
CG8839 |
53.01(n) 47.61(a) |
36340 NM_165886.2 NP_725139.1 |
worm (Caenorhabditis elegans) |
Y53F4B.181 |
-- |
hypothetical protein |
47.6(n) 40.33(a) |
190217 NM_064702.1 NP_497103.1 |
African malaria mosquito (Anopheles gambiae) |
AgaP_AGAP0113151 |
-- |
AGAP011315-PA |
51.38(n) 47.93(a) |
1270620 XM_309335.2 XP_309335.2 |
rice blast fungus (Magnaporthe grisea) |
MGG_027261 |
-- |
hypothetical protein |
41.38(n) 28.51(a) |
2682326 XM_366650.1 XP_366650.1 |
About this table Species with no ortholog for FAAH2
ENSEMBL Gene Tree for FAAH2 | Paralogs for FAAH2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FAAH2 gene
- FAAH2 QRSL12
|
SNPs/Variants for FAAH2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FAAH2 (up to first 250kb)
|
Disorders & Mutations for FAAH2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300654
|
Medical News for FAAH2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FAAH2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for FAAH2 gene:- A second fatty acid amide hydrolase with variable distribution among placental mammals. (PubMed id 17015445)2, 3, 4 Wei B.Q.... Cravatt B.F. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. (PubMed id 19095868)3 Karbarz M.J....Webb M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)4 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for FAAH2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAAH2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FAAH2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAAH2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FAAH2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FAAH2:

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 |  |  |
| | | | Tocris compounds for FAAH2 |
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Incremental update: 13 Oct 2009
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