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Aliases for FAAH2 Gene

Aliases for FAAH2 Gene

  • Fatty Acid Amide Hydrolase 2 2 3
  • Amidase Domain-Containing Protein 3 4
  • Anandamide Amidohydrolase 2 3 4
  • Amidase Domain Containing 2 3
  • Oleamide Hydrolase 2 3 4
  • AMDD 3 4
  • Fatty-Acid Amide Hydrolase 2 3
  • EC 3.5.1.99 4

External Ids for FAAH2 Gene

Previous Symbols for FAAH2 Gene

  • AMDD

Summaries for FAAH2 Gene

Entrez Gene Summary for FAAH2 Gene

  • This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.[provided by RefSeq, Sep 2009]

GeneCards Summary for FAAH2 Gene

FAAH2 (Fatty Acid Amide Hydrolase 2) is a Protein Coding gene. Among its related pathways are anandamide degradation. GO annotations related to this gene include hydrolase activity and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH.

UniProtKB/Swiss-Prot for FAAH2 Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Tocris Summary for FAAH2 Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH2 Gene

Genomics for FAAH2 Gene

Genomic Location for FAAH2 Gene

Start:
57,286,578 bp from pter
End:
57,489,196 bp from pter
Size:
202,619 bases
Orientation:
Plus strand

Genomic View for FAAH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAAH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH2 Gene

Regulatory Elements for FAAH2 Gene

Proteins for FAAH2 Gene

  • Protein details for FAAH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMR7-FAAH2_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 2
    Protein Accession:
    Q6GMR7
    Secondary Accessions:
    • Q86VT2
    • Q96N98

    Protein attributes for FAAH2 Gene

    Size:
    532 amino acids
    Molecular mass:
    58304 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH2 Gene

Proteomics data for FAAH2 Gene at MOPED

Post-translational modifications for FAAH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAAH2 Gene

Domains for FAAH2 Gene

Gene Families for FAAH2 Gene

Protein Domains for FAAH2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

FAAH2_HUMAN
Family:
  • Belongs to the amidase family.:
    • Q6GMR7
genes like me logo Genes that share domains with FAAH2: view

Function for FAAH2 Gene

Molecular function for FAAH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Anandamide + H(2)O = arachidonic acid + ethanolamine
UniProtKB/Swiss-Prot CatalyticActivity: Oleamide + H(2)O = oleic acid + NH(3)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH2 Gene

Gene Ontology (GO) - Molecular Function for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA --
genes like me logo Genes that share ontologies with FAAH2: view

miRNA for FAAH2 Gene

miRTarBase miRNAs that target FAAH2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAAH2 Gene

Localization for FAAH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAAH2 Gene COMPARTMENTS Subcellular localization image for FAAH2 gene
Compartment Confidence
golgi apparatus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAAH2: view

Pathways for FAAH2 Gene

SuperPathways for FAAH2 Gene

Superpath Contained pathways
1 anandamide degradation
genes like me logo Genes that share pathways with FAAH2: view

Pathways by source for FAAH2 Gene

1 BioSystems pathway for FAAH2 Gene

Interacting Proteins for FAAH2 Gene

Gene Ontology (GO) - Biological Process for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with FAAH2: view

Compounds for FAAH2 Gene

(4) Tocris Compounds for FAAH2 Gene

Compound Action Cas Number
JNJ 1661010 Selective, reversible FAAH inhibitor [681136-29-8]
PF 3845 Selective FAAH inhibitor [1196109-52-0]
SA 57 Potent FAAH inhibitor [1346169-63-8]
TC-F 2 Potent, reversible and selective FAAH inhibitor [1304778-15-1]

(1) HMDB Compounds for FAAH2 Gene

Compound Synonyms Cas Number PubMed IDs
Anandamide
  • Anandamide (20.4, n-6)
94421-68-8

(2) IUPHAR Ligand for FAAH2 Gene

Ligand Type Action Affinity Pubmed IDs
OL135 Inhibitor Inhibition 7.4
URB597 Activator Agonist 4.6
genes like me logo Genes that share compounds with FAAH2: view

Transcripts for FAAH2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH2 Gene

No ASD Table

Relevant External Links for FAAH2 Gene

GeneLoc Exon Structure for
FAAH2
ECgene alternative splicing isoforms for
FAAH2

Expression for FAAH2 Gene

mRNA expression in normal human tissues for FAAH2 Gene

mRNA differential expression in normal tissues according to GTEx for FAAH2 Gene

This gene is overexpressed in Pancreas (7.3) and Liver (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAAH2 Gene

SOURCE GeneReport for Unigene cluster for FAAH2 Gene Hs.496205

mRNA Expression by UniProt/SwissProt for FAAH2 Gene

Q6GMR7-FAAH2_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate.
genes like me logo Genes that share expressions with FAAH2: view

Orthologs for FAAH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAAH2 36
  • 99.06 (n)
  • 98.31 (a)
FAAH2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 21 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 16 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia FAAH2 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH2 37
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAAH2 36
  • 63.95 (n)
  • 64.03 (a)
FAAH2 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAAH2 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faah2 36
  • 60.44 (n)
  • 58.32 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16832 36
faah2a 36
  • 59.83 (n)
  • 57.85 (a)
faah2a 37
  • 55 (a)
OneToMany
faah2b 37
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011315 36
  • 51.35 (n)
  • 48.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5112 37
  • 37 (a)
OneToMany
CG7900 37
  • 33 (a)
OneToMany
CG7910 37
  • 34 (a)
OneToMany
CG8839 36
  • 52.9 (n)
  • 47.51 (a)
CG8839 37
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.18 36
  • 48.07 (n)
  • 40.5 (a)
Y53F4B.18 37
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 37
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09102 36
  • 41.42 (n)
  • 28.09 (a)
Species with no ortholog for FAAH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAAH2 Gene

ENSEMBL:
Gene Tree for FAAH2 (if available)
TreeFam:
Gene Tree for FAAH2 (if available)

Paralogs for FAAH2 Gene

Paralogs for FAAH2 Gene

Selected SIMAP similar genes for FAAH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAAH2: view

Variants for FAAH2 Gene

Sequence variations from dbSNP and Humsavar for FAAH2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs394063 -- 57,412,425(-) gaaca(C/G)tagga intron-variant
rs715099 -- 57,392,335(-) CTCCA(C/G)TCTCA intron-variant
rs717848 -- 57,406,870(-) GGTTG(C/T)TCGTC intron-variant
rs957721 -- 57,288,978(-) AAAAA(A/T)GTCAG intron-variant, upstream-variant-2KB
rs967784 -- 57,355,147(+) CCCCA(C/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH2 Gene

Variant ID Type Subtype PubMed ID
dgv514n21 CNV Gain 19592680

Relevant External Links for FAAH2 Gene

HapMap Linkage Disequilibrium report
FAAH2
Human Gene Mutation Database (HGMD)
FAAH2
Locus Specific Mutation Databases (LSDB)
FAAH2

Disorders for FAAH2 Gene

No disorders were found for FAAH2 Gene.

No data available for UniProtKB/Swiss-Prot for FAAH2 Gene

Publications for FAAH2 Gene

  1. A second fatty acid amide hydrolase with variable distribution among placental mammals. (PMID: 17015445) Wei B.Q. … Cravatt B.F. (J. Biol. Chem. 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. (PMID: 19095868) Karbarz M.J. … Webb M. (Anesth. Analg. 2009) 3

Products for FAAH2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate FAAH2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FAAH2
    • Block miRNA regulation of FAAH2 using miScript Target Protectors

    Sources for FAAH2 Gene

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