Aliases for FAAH2 Gene
External Ids for FAAH2 Gene
Previous HGNC Symbols for FAAH2 Gene
Previous GeneCards Identifiers for FAAH2 Gene
This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.[provided by RefSeq, Sep 2009]
GeneCards Summary for FAAH2 Gene
FAAH2 (Fatty Acid Amide Hydrolase 2) is a Protein Coding gene. Among its related pathways are anandamide degradation. GO annotations related to this gene include hydrolase activity and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH.
UniProtKB/Swiss-Prot for FAAH2 Gene
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.