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Aliases for FAAH2 Gene

Aliases for FAAH2 Gene

  • Fatty Acid Amide Hydrolase 2 2 3
  • Amidase Domain-Containing Protein 3 4
  • Anandamide Amidohydrolase 2 3 4
  • Amidase Domain Containing 2 3
  • Oleamide Hydrolase 2 3 4
  • AMDD 3 4
  • EC 3.5.1.99 4

External Ids for FAAH2 Gene

Previous HGNC Symbols for FAAH2 Gene

  • AMDD

Previous GeneCards Identifiers for FAAH2 Gene

  • GC0XP057330
  • GC0XP054375

Summaries for FAAH2 Gene

Entrez Gene Summary for FAAH2 Gene

  • This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.[provided by RefSeq, Sep 2009]

GeneCards Summary for FAAH2 Gene

FAAH2 (Fatty Acid Amide Hydrolase 2) is a Protein Coding gene. Diseases associated with FAAH2 include acromesomelic dysplasia, demirhan type and brachydactyly, type a2. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include hydrolase activity and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH.

UniProtKB/Swiss-Prot for FAAH2 Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Tocris Summary for FAAH2 Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH2 Gene

Genomics for FAAH2 Gene

Regulatory Elements for FAAH2 Gene

Genomic Location for FAAH2 Gene

Chromosome:
X
Start:
57,121,879 bp from pter
End:
57,489,196 bp from pter
Size:
367,318 bases
Orientation:
Plus strand

Genomic View for FAAH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAAH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH2 Gene

Proteins for FAAH2 Gene

  • Protein details for FAAH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMR7-FAAH2_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 2
    Protein Accession:
    Q6GMR7
    Secondary Accessions:
    • Q86VT2
    • Q96N98

    Protein attributes for FAAH2 Gene

    Size:
    532 amino acids
    Molecular mass:
    58304 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH2 Gene

Proteomics data for FAAH2 Gene at MOPED

Post-translational modifications for FAAH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAAH2 Gene

Domains & Families for FAAH2 Gene

Gene Families for FAAH2 Gene

Protein Domains for FAAH2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAAH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GMR7

UniProtKB/Swiss-Prot:

FAAH2_HUMAN :
  • Belongs to the amidase family.
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH2: view

Function for FAAH2 Gene

Molecular function for FAAH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Anandamide + H(2)O = arachidonic acid + ethanolamine
UniProtKB/Swiss-Prot CatalyticActivity:
Oleamide + H(2)O = oleic acid + NH(3)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH2 Gene

Gene Ontology (GO) - Molecular Function for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA --
genes like me logo Genes that share ontologies with FAAH2: view

Phenotypes for FAAH2 Gene

GenomeRNAi human phenotypes for FAAH2:
genes like me logo Genes that share phenotypes with FAAH2: view

Animal Model Products

CRISPR Products

miRNA for FAAH2 Gene

miRTarBase miRNAs that target FAAH2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAAH2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FAAH2 Gene

Localization for FAAH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAAH2 Gene COMPARTMENTS Subcellular localization image for FAAH2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAAH2: view

Pathways & Interactions for FAAH2 Gene

genes like me logo Genes that share pathways with FAAH2: view

Pathways by source for FAAH2 Gene

1 BioSystems pathway for FAAH2 Gene

Interacting Proteins for FAAH2 Gene

Gene Ontology (GO) - Biological Process for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with FAAH2: view

No data available for SIGNOR curated interactions for FAAH2 Gene

Drugs & Compounds for FAAH2 Gene

(9) Drugs for FAAH2 Gene - From: HMDB, Tocris, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanolamine Experimental Pharma 0
oleic acid Experimental Pharma Activation, Activator 0
arachidonic acid Experimental Nutra Potentiation, Activator 27
OL135 Pharma Inhibition, Inhibitor 0
URB597 Pharma Agonist, Activator FAAH inhibitor,potent and selective 0

(5) Additional Compounds for FAAH2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
ARN 272
488793-85-7
PF 750
959151-50-9
TC-F 2
1304778-15-1
genes like me logo Genes that share compounds with FAAH2: view

Transcripts for FAAH2 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAAH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH2 Gene

No ASD Table

Relevant External Links for FAAH2 Gene

GeneLoc Exon Structure for
FAAH2
ECgene alternative splicing isoforms for
FAAH2

Expression for FAAH2 Gene

mRNA expression in normal human tissues for FAAH2 Gene

mRNA differential expression in normal tissues according to GTEx for FAAH2 Gene

This gene is overexpressed in Pancreas (x7.3) and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for FAAH2 Gene

This gene is overexpressed in Lung (30.1), Heart (16.5), Peripheral blood mononuclear cells (13.5), and Spleen (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAAH2 Gene



SOURCE GeneReport for Unigene cluster for FAAH2 Gene Hs.496205

mRNA Expression by UniProt/SwissProt for FAAH2 Gene

Q6GMR7-FAAH2_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate.
genes like me logo Genes that share expression patterns with FAAH2: view

Protein tissue co-expression partners for FAAH2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FAAH2 Gene

Orthologs for FAAH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAAH2 35
  • 99.06 (n)
  • 98.31 (a)
FAAH2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 21 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 16 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia FAAH2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAAH2 35
  • 63.95 (n)
  • 64.03 (a)
FAAH2 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAAH2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faah2 35
  • 60.44 (n)
  • 58.32 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16832 35
faah2a 35
  • 59.83 (n)
  • 57.85 (a)
faah2a 36
  • 55 (a)
OneToMany
faah2b 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011315 35
  • 51.35 (n)
  • 48.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8839 35
  • 52.9 (n)
  • 47.51 (a)
CG5112 36
  • 37 (a)
OneToMany
CG7900 36
  • 33 (a)
OneToMany
CG7910 36
  • 34 (a)
OneToMany
CG8839 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.18 35
  • 48.07 (n)
  • 40.5 (a)
Y53F4B.18 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 36
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09102 35
  • 41.42 (n)
  • 28.09 (a)
Species with no ortholog for FAAH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAAH2 Gene

ENSEMBL:
Gene Tree for FAAH2 (if available)
TreeFam:
Gene Tree for FAAH2 (if available)

Paralogs for FAAH2 Gene

Paralogs for FAAH2 Gene

(1) SIMAP similar genes for FAAH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAAH2: view

Variants for FAAH2 Gene

Sequence variations from dbSNP and Humsavar for FAAH2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs363889 -- 57,133,291(-) ctgat(A/G)atgta intron-variant
rs363920 -- 57,133,201(-) aataa(A/G)taagc intron-variant
rs364031 -- 57,133,283(+) ttcat(G/T)attac intron-variant
rs385887 -- 57,133,470(+) TGTGC(A/C)TTTTA intron-variant
rs394063 -- 57,412,425(-) gaaca(C/G)tagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH2 Gene

Variant ID Type Subtype PubMed ID
dgv514n21 CNV Gain 19592680

Variation tolerance for FAAH2 Gene

Residual Variation Intolerance Score: 96.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAAH2 Gene

HapMap Linkage Disequilibrium report
FAAH2
Human Gene Mutation Database (HGMD)
FAAH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH2 Gene

Disorders for FAAH2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAAH2 Gene - From: OMIM

Disorder Aliases PubMed IDs
acromesomelic dysplasia, demirhan type
  • acromesomelic chondrodysplasia, with genital anomalies
brachydactyly, type a2
  • brachydactyly type a2
- elite association
Search FAAH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAAH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAAH2
genes like me logo Genes that share disorders with FAAH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH2 Gene

Publications for FAAH2 Gene

  1. A second fatty acid amide hydrolase with variable distribution among placental mammals. (PMID: 17015445) Wei B.Q. … Cravatt B.F. (J. Biol. Chem. 2006) 2 67
  2. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  4. Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. (PMID: 19926788) Kaczocha M. … Deutsch D.G. (J. Biol. Chem. 2010) 67
  5. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. (PMID: 19095868) Karbarz M.J. … Webb M. (Anesth. Analg. 2009) 67

Products for FAAH2 Gene

Sources for FAAH2 Gene

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