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Aliases for FAAH2 Gene

Aliases for FAAH2 Gene

  • Fatty Acid Amide Hydrolase 2 2 3 5
  • Amidase Domain-Containing Protein 3 4
  • Anandamide Amidohydrolase 2 3 4
  • Amidase Domain Containing 2 3
  • Oleamide Hydrolase 2 3 4
  • AMDD 3 4
  • EC 4

External Ids for FAAH2 Gene

Previous HGNC Symbols for FAAH2 Gene

  • AMDD

Previous GeneCards Identifiers for FAAH2 Gene

  • GC0XP057330
  • GC0XP054375

Summaries for FAAH2 Gene

Entrez Gene Summary for FAAH2 Gene

  • This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate.[provided by RefSeq, Sep 2009]

GeneCards Summary for FAAH2 Gene

FAAH2 (Fatty Acid Amide Hydrolase 2) is a Protein Coding gene. Diseases associated with FAAH2 include Acromesomelic Dysplasia, Demirhan Type and Brachydactyly, Type A2. Among its related pathways are Arachidonic acid metabolism and Metabolism. GO annotations related to this gene include hydrolase activity and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH.

UniProtKB/Swiss-Prot for FAAH2 Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Tocris Summary for FAAH2 Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH2 Gene

Genomics for FAAH2 Gene

Regulatory Elements for FAAH2 Gene

Enhancers for FAAH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAAH2 on UCSC Golden Path with GeneCards custom track

Promoters for FAAH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAAH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAAH2 Gene

57,121,879 bp from pter
57,489,196 bp from pter
367,318 bases
Plus strand

Genomic View for FAAH2 Gene

Genes around FAAH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAAH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAAH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH2 Gene

Proteins for FAAH2 Gene

  • Protein details for FAAH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fatty-acid amide hydrolase 2
    Protein Accession:
    Secondary Accessions:
    • Q86VT2
    • Q96N98

    Protein attributes for FAAH2 Gene

    532 amino acids
    Molecular mass:
    58304 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH2 Gene

Proteomics data for FAAH2 Gene at MOPED

Post-translational modifications for FAAH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAAH2 Gene

Domains & Families for FAAH2 Gene

Gene Families for FAAH2 Gene

Protein Domains for FAAH2 Gene


Suggested Antigen Peptide Sequences for FAAH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amidase family.
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH2: view

Function for FAAH2 Gene

Molecular function for FAAH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Anandamide + H(2)O = arachidonic acid + ethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleamide + H(2)O = oleic acid + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH2 Gene

Gene Ontology (GO) - Molecular Function for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017064 fatty acid amide hydrolase activity TAS --
genes like me logo Genes that share ontologies with FAAH2: view

Phenotypes for FAAH2 Gene

GenomeRNAi human phenotypes for FAAH2:
genes like me logo Genes that share phenotypes with FAAH2: view

Animal Model Products

CRISPR Products

miRNA for FAAH2 Gene

miRTarBase miRNAs that target FAAH2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAAH2 Gene

Localization for FAAH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAAH2 Gene COMPARTMENTS Subcellular localization image for FAAH2 gene
Compartment Confidence
cytoskeleton 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FAAH2 Gene

Pathways & Interactions for FAAH2 Gene

genes like me logo Genes that share pathways with FAAH2: view

Pathways by source for FAAH2 Gene

1 BioSystems pathway for FAAH2 Gene

Interacting Proteins for FAAH2 Gene

Gene Ontology (GO) - Biological Process for FAAH2 Gene


No data available for SIGNOR curated interactions for FAAH2 Gene

Drugs & Compounds for FAAH2 Gene

(7) Drugs for FAAH2 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanolamine Experimental Pharma 0
oleic acid Experimental Pharma Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 27
OL135 Pharma Inhibition, Inhibitor 0
URB597 Pharma Inhibition, Inhibitor FAAH inhibitor,potent and selective 0

(7) Additional Compounds for FAAH2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
  • Dihydrogen oxide
  • Steam
Arachidonyl serotonin
LY 2183240

(5) Tocris Compounds for FAAH2 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Arachidonyl serotonin Dual FAAH inhibitor/TRPV1 antagonist 187947-37-1
LY 2183240 Novel, potent anandamide uptake inhibitor; inhibits FAAH 874902-19-9
Palmitoylisopropylamide Inhibitor of FAAH 189939-61-5
PDP-EA FAAH activator 861891-72-7
genes like me logo Genes that share compounds with FAAH2: view

Transcripts for FAAH2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH2 Gene

No ASD Table

Relevant External Links for FAAH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAAH2 Gene

mRNA expression in normal human tissues for FAAH2 Gene

mRNA differential expression in normal tissues according to GTEx for FAAH2 Gene

This gene is overexpressed in Pancreas (x7.3) and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for FAAH2 Gene

This gene is overexpressed in Lung (30.1), Heart (16.5), Peripheral blood mononuclear cells (13.5), and Spleen (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAAH2 Gene

SOURCE GeneReport for Unigene cluster for FAAH2 Gene Hs.496205

mRNA Expression by UniProt/SwissProt for FAAH2 Gene

Tissue specificity: Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate.
genes like me logo Genes that share expression patterns with FAAH2: view

Protein tissue co-expression partners for FAAH2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FAAH2 Gene

Orthologs for FAAH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAAH2 35
  • 99.06 (n)
  • 98.31 (a)
FAAH2 36
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 21 (a)
(Canis familiaris)
Mammalia -- 36
  • 16 (a)
(Monodelphis domestica)
Mammalia FAAH2 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia FAAH2 36
  • 67 (a)
(Gallus gallus)
Aves FAAH2 35
  • 63.95 (n)
  • 64.03 (a)
FAAH2 36
  • 61 (a)
(Anolis carolinensis)
Reptilia FAAH2 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia faah2 35
  • 60.44 (n)
  • 58.32 (a)
(Danio rerio)
Actinopterygii Dr.16832 35
faah2a 35
  • 59.83 (n)
  • 57.85 (a)
faah2a 36
  • 55 (a)
faah2b 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011315 35
  • 51.35 (n)
  • 48.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8839 35
  • 52.9 (n)
  • 47.51 (a)
CG5112 36
  • 37 (a)
CG7900 36
  • 33 (a)
CG7910 36
  • 34 (a)
CG8839 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.18 35
  • 48.07 (n)
  • 40.5 (a)
Y53F4B.18 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 36
  • 18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09102 35
  • 41.42 (n)
  • 28.09 (a)
Species with no ortholog for FAAH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAAH2 Gene

Gene Tree for FAAH2 (if available)
Gene Tree for FAAH2 (if available)

Paralogs for FAAH2 Gene

Paralogs for FAAH2 Gene

(1) SIMAP similar genes for FAAH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAAH2: view

Variants for FAAH2 Gene

Sequence variations from dbSNP and Humsavar for FAAH2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747675447 -- 57,179,699(+) GTATT(-/AGAC)AGAAC intron-variant
rs747679702 -- 57,415,878(+) GGTCT(C/T)TAAGA intron-variant
rs747691812 -- 57,183,323(+) TAGTC(A/C)TAATG intron-variant
rs747692786 -- 57,403,576(+) TGTGG(A/G)TAACC intron-variant
rs747701121 -- 57,371,949(+) TCAGG(C/G)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH2 Gene

Variant ID Type Subtype PubMed ID
dgv514n21 CNV Gain 19592680

Variation tolerance for FAAH2 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAAH2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH2 Gene

Disorders for FAAH2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAAH2 Gene - From: OMIM

Disorder Aliases PubMed IDs
acromesomelic dysplasia, demirhan type
  • acromesomelic chondrodysplasia, with genital anomalies
brachydactyly, type a2
  • brachydactyly type a2
- elite association - COSMIC cancer census association via MalaCards
Search FAAH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAAH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAAH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH2 Gene

Publications for FAAH2 Gene

  1. A second fatty acid amide hydrolase with variable distribution among placental mammals. (PMID: 17015445) Wei B.Q. … Cravatt B.F. (J. Biol. Chem. 2006) 2 3 4 67
  2. Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms. (PMID: 25885783) Sirrs S. … Kaczocha M. (Orphanet J Rare Dis 2015) 3
  3. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. (PMID: 19926788) Kaczocha M. … Deutsch D.G. (J. Biol. Chem. 2010) 3

Products for FAAH2 Gene

Sources for FAAH2 Gene