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Aliases for FAAH2 Gene

Aliases for FAAH2 Gene

  • Fatty Acid Amide Hydrolase 2 2 3 5
  • Amidase Domain-Containing Protein 3 4
  • Anandamide Amidohydrolase 2 3 4
  • Amidase Domain Containing 2 3
  • Oleamide Hydrolase 2 3 4
  • AMDD 3 4
  • Fatty-Acid Amide Hydrolase 2 3
  • EC 3.5.1.99 4

External Ids for FAAH2 Gene

Previous HGNC Symbols for FAAH2 Gene

  • AMDD

Previous GeneCards Identifiers for FAAH2 Gene

  • GC0XP057330
  • GC0XP054375

Summaries for FAAH2 Gene

Entrez Gene Summary for FAAH2 Gene

  • This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

GeneCards Summary for FAAH2 Gene

FAAH2 (Fatty Acid Amide Hydrolase 2) is a Protein Coding gene. Diseases associated with FAAH2 include Kidney Benign Neoplasm. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include hydrolase activity and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH.

UniProtKB/Swiss-Prot for FAAH2 Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Tocris Summary for FAAH2 Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

Additional gene information for FAAH2 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH2 Gene

Genomics for FAAH2 Gene

Regulatory Elements for FAAH2 Gene

Enhancers for FAAH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH057908 0.7 ENCODE 5.9 +788.4 788398 2 TBP KLF1 JUN ZIC2 HIC1 GLIS2 PATZ1 FOS ATF7 ZBTB20 MTHFD1P1 FAAH2 ZXDA GC0XP057893
GH0XH058097 0.5 dbSUPER 5 +978.3 978271 4 JUND CREB1 ATF7 ATF2 FAAH2 KRT8P17 PIR52807
GH0XH057906 0.4 Ensembl 5 +784.8 784811 0 JUND FAAH2 ZXDA GC0XP057893
GH0XH057950 0.4 ENCODE 5 +830.1 830136 2 POLR2A NR2F2 MTHFD1P1 FAAH2 MYCLP2 KRT8P17
GH0XH058103 0.2 dbSUPER 5.2 +984.1 984085 5 SPIN2B FAAH2 ZXDB KRT8P17 PIR52807
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAAH2 on UCSC Golden Path with GeneCards custom track

Promoters for FAAH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246810 -378 2199 ARID4B SIN3A ZNF2 YY1 GLIS2 ZNF207 ATF7 SP3 SP5 KAT8

Genomic Location for FAAH2 Gene

Chromosome:
X
Start:
57,121,879 bp from pter
End:
57,489,196 bp from pter
Size:
367,318 bases
Orientation:
Plus strand

Genomic View for FAAH2 Gene

Genes around FAAH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAAH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAAH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH2 Gene

Proteins for FAAH2 Gene

  • Protein details for FAAH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMR7-FAAH2_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 2
    Protein Accession:
    Q6GMR7
    Secondary Accessions:
    • Q86VT2
    • Q96N98

    Protein attributes for FAAH2 Gene

    Size:
    532 amino acids
    Molecular mass:
    58304 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH2 Gene

Post-translational modifications for FAAH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAAH2 Gene

Domains & Families for FAAH2 Gene

Gene Families for FAAH2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FAAH2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAAH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GMR7

UniProtKB/Swiss-Prot:

FAAH2_HUMAN :
  • Belongs to the amidase family.
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH2: view

Function for FAAH2 Gene

Molecular function for FAAH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Anandamide + H(2)O = arachidonic acid + ethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleamide + H(2)O = oleic acid + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH2 Gene

Phenotypes From GWAS Catalog for FAAH2 Gene

Gene Ontology (GO) - Molecular Function for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0017064 fatty acid amide hydrolase activity TAS --
GO:0102077 oleamide hydrolase activity IEA --
GO:0103073 anandamide amidohydrolase activity IEA --
genes like me logo Genes that share ontologies with FAAH2: view

Phenotypes for FAAH2 Gene

GenomeRNAi human phenotypes for FAAH2:
genes like me logo Genes that share phenotypes with FAAH2: view

Animal Model Products

CRISPR Products

miRNA for FAAH2 Gene

miRTarBase miRNAs that target FAAH2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAAH2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAAH2 Gene

Localization for FAAH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAAH2 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
golgi apparatus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAAH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAAH2 Gene

Pathways & Interactions for FAAH2 Gene

genes like me logo Genes that share pathways with FAAH2: view

Pathways by source for FAAH2 Gene

1 BioSystems pathway for FAAH2 Gene

Gene Ontology (GO) - Biological Process for FAAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with FAAH2: view

No data available for SIGNOR curated interactions for FAAH2 Gene

Drugs & Compounds for FAAH2 Gene

(12) Drugs for FAAH2 Gene - From: DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Water Approved Pharma 0
Ethanolamine Experimental Pharma 0
arachidonic acid Experimental Nutra Activator 32

(2) Additional Compounds for FAAH2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PDP-EA
861891-72-7
URB 597
546141-08-6

(5) Tocris Compounds for FAAH2 Gene

Compound Action Cas Number
JNJ 1661010 Selective, reversible FAAH inhibitor 681136-29-8
PDP-EA FAAH activator 861891-72-7
PF 3845 Selective FAAH inhibitor 1196109-52-0
TC-F 2 Potent, reversible and selective FAAH inhibitor 1304778-15-1
URB 597 Potent and selective FAAH inhibitor 546141-08-6
genes like me logo Genes that share compounds with FAAH2: view

Transcripts for FAAH2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAAH2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH2 Gene

No ASD Table

Relevant External Links for FAAH2 Gene

GeneLoc Exon Structure for
FAAH2
ECgene alternative splicing isoforms for
FAAH2

Expression for FAAH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAAH2 Gene

mRNA differential expression in normal tissues according to GTEx for FAAH2 Gene

This gene is overexpressed in Pancreas (x7.3) and Liver (x4.4).

Protein differential expression in normal tissues from HIPED for FAAH2 Gene

This gene is overexpressed in Lung (30.1), Heart (16.5), Peripheral blood mononuclear cells (13.5), and Spleen (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAAH2 Gene



Protein tissue co-expression partners for FAAH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAAH2 Gene:

FAAH2

SOURCE GeneReport for Unigene cluster for FAAH2 Gene:

Hs.496205

mRNA Expression by UniProt/SwissProt for FAAH2 Gene:

Q6GMR7-FAAH2_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate.

Evidence on tissue expression from TISSUES for FAAH2 Gene

  • Kidney(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with FAAH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAAH2 Gene

Orthologs for FAAH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAAH2 34 33
  • 99.06 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAAH2 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH2 34
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 21 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FAAH2 34 33
  • 63.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAAH2 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia faah2 33
  • 60.44 (n)
zebrafish
(Danio rerio)
Actinopterygii faah2a 34 33
  • 59.83 (n)
OneToMany
faah2b 34
  • 52 (a)
OneToMany
Dr.16832 33
fruit fly
(Drosophila melanogaster)
Insecta CG8839 33 34
  • 52.9 (n)
CG5112 34
  • 37 (a)
OneToMany
CG7910 34
  • 34 (a)
OneToMany
CG7900 34
  • 33 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011315 33
  • 51.35 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.18 33
  • 48.07 (n)
Y53F4B.18 34
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 34
  • 18 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09102 33
  • 41.42 (n)
Species where no ortholog for FAAH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAAH2 Gene

ENSEMBL:
Gene Tree for FAAH2 (if available)
TreeFam:
Gene Tree for FAAH2 (if available)

Paralogs for FAAH2 Gene

Paralogs for FAAH2 Gene

(1) SIMAP similar genes for FAAH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAAH2: view

Variants for FAAH2 Gene

Sequence variations from dbSNP and Humsavar for FAAH2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs201024763 Likely benign 57,331,760(+) TGGCC(A/G)ATCAA intron-variant, nc-transcript-variant, reference, missense
rs147173444 Uncertain significance 57,448,667(+) CAGTG(A/G/T)CACCT intron-variant, nc-transcript-variant, reference, missense
rs1367830 Benign 57,448,699(-) TTGAA(A/G)GGCCG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1821118 Benign 57,448,510(-) TGATA(A/T)CATAT intron-variant
rs1000013366 -- 57,150,787(+) TGTGA(A/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH2 Gene

Variant ID Type Subtype PubMed ID
dgv514n21 CNV gain 19592680
esv3558902 CNV deletion 23714750
nsv1140397 OTHER inversion 24896259

Variation tolerance for FAAH2 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAAH2 Gene

Human Gene Mutation Database (HGMD)
FAAH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAAH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH2 Gene

Disorders for FAAH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAAH2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
kidney benign neoplasm
  • renal and ureteral tumor
- elite association - COSMIC cancer census association via MalaCards
Search FAAH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAAH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAAH2
genes like me logo Genes that share disorders with FAAH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH2 Gene

Publications for FAAH2 Gene

  1. A second fatty acid amide hydrolase with variable distribution among placental mammals. (PMID: 17015445) Wei BQ … Cravatt BF (The Journal of biological chemistry 2006) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms. (PMID: 25885783) Sirrs S … Kaczocha M (Orphanet journal of rare diseases 2015) 3 60
  4. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson TP … Nath A (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 60
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 60

Products for FAAH2 Gene

Sources for FAAH2 Gene

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