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Aliases & Descriptions for FAAH
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.5.1.n2 3 | | FAAH-1 1, 2 | | FAAH1 3 | | MGC102823 2 | | MGC138146 2 | | OTTHUMP00000009480 2 |
| | | Descriptions |
|---|
| Anandamide amidohydrolase 1 3 | | Oleamide hydrolase 1 3 | | fatty acid amide hydrolase 2 |
|
| | Search outside databases for aliases for FAAH genePrevious GC identifers: GC01P046501 GC01P045816 GC01P046246 GC01P046229 GC01P046572 |
Summaries for FAAH(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FAAH: This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq] UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates |
Genomic Location for FAAH
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FAAH gene 
Entrez Gene cytogenetic band: 1p35-p34 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p35-p34FAAH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P046632:
(about GC identifiers)
Start:
|
46,632,575 bp from pter |
End:
|
46,652,104 bp from pter |
Size:
|
19,530 bases |
Orientation:
|
plus strand |
| Proteins for FAAH
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519 (See
protein sequence)Recommended Name: Fatty-acid amide hydrolase 1 Size: 579 amino acids; 63066 Da
Subunit: Homodimer (By similarity)
Subcellular location: Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network
Secondary accessions: Q52M86 Q5TDF8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001432.2
ENSEMBL proteins: ENSP00000379617 ENSP00000243167
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for FAAH: Assays for FAAH: | Protein
Domains/ Families for FAAH(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O00519
ProtoNet protein and cluster: O00519 1 Blocks protein family: IPB000120 Amidase
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Similarity: Belongs to the amidase family | Gene Function for FAAH
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001441
Applied Biosystems Silencer® siRNAs for FAAH
Sigma-Aldrich siRNA and siRNA Panels for FAAH  Sigma-Aldrich shRNA for FAAH  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001441                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001441                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001441 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001441
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substratesEnzyme regulation: Inhibited by O-aryl carbamates and alpha-keto heterocytesEnzyme Number (IUBMB): EC 3.5.1.n2 Genatlas biochemistry entry for FAAH:fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acids such as oleamide and anandamide4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Faah):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004040 | amidase activity |
TAS | 10431820 | | GO:0005543 | phospholipid binding |
IEA | -- | | GO:0016788 | hydrolase activity, acting on ester bonds |
IEA | -- | | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
IEA | -- | | GO:0017064 | fatty acid amide hydrolase activity |
IEA | -- | About this table | Pathways & Interactions for FAAH
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for FAAH (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FAAH 
5/7 Interacting proteins for FAAH (ENSP000002431673) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009062 | fatty acid catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for FAAH(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for FAAH |
 | Sigma-Aldrich Small Molecules for FAAH: Inhibitor |
Compounds for FAAH available from Tocris Bioscience About this table
10/22 Novoseek chemical compound relationships for FAAH gene (see all 22
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| urb 597 |
91.90 |
28 |
18814866 (3), 17314320 (2), 17511970 (2), 16834756 (2) (see all 14) |
| linoleoyl ethanolamide |
83.87 |
1 |
9822713 (1) |
| glyceryl arachidonate |
83.87 |
1 |
16181610 (1) |
| ethanolamine |
75.70 |
21 |
15974992 (1), 15923084 (1), 17676056 (1), 11118429 (1) (see all 15) |
| rimonabant |
68.32 |
1 |
16129456 (1) |
| oxazole |
56.96 |
3 |
17279740 (1), 18630870 (1) |
| arachidonic acid |
55.52 |
18 |
11095952 (2), 16018870 (1), 11118429 (1), 18455484 (1) (see all 11) |
| amide |
46.72 |
6 |
12734197 (2), 12781177 (1), 17098788 (1), 17291440 (1) (see all 5) |
| lipid |
44.44 |
27 |
15993425 (2), 15533037 (1), 16584138 (1), 15292270 (1) (see all 16) |
| am251 |
42.50 |
1 |
17279090 (1) |
About this table
|
Transcripts for FAAH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001441
Sigma-Aldrich siRNA and siRNA Panels for FAAH  Sigma-Aldrich shRNA for FAAH  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001441 REFSEQ mRNAs for FAAH gene: NM_001441.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001441               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001441                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001441                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001441  24/336 AceView cDNA sequences (see all 336
):AA329007 AI951464 BF913261 CA502993 AI686717 AL042017 CR620787 AI920966 AA887288 CB049339 CR624794 BF436906 AI375665 AI274566 CF529182 CB266514 AW261990 CR625030 AK097524 AI468284 CA395976 U82535 AL042404 AL042018
highest scoring ESTs for FAAH:AL050372 U82535 AA322200 AA429711 AA431988 AA435742 AA468882 AA526580 AA582943 AA662365
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAAH
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for FAAH
2 Ensembl transcripts including schematic representations: ENST00000396325
ENST00000243167
|
Expression for FAAH
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FAAH expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FAAH
1 / 2 / 3 4 probe-sets matching FAAH gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
Expression variation in blood from EXPOLDB for FAAH UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate |
Orthologs for FAAH
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FAAH gene from 5/11 species (see all 11
)
About this table Species with no ortholog for FAAH
ENSEMBL Gene Tree for FAAH | Paralogs for FAAH(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FAAH gene
- FAAH22 QRSL12
|
SNPs/Variants for FAAH(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Polymorphism: Variant Thr-129 seems to be strongly associated with illegal drug use and dependence. This variant displays normal catalytic properties but an enhanced sensitivity to proteolytic degradation
HapMap Linkage Disequilibrium images for FAAH (up to first 250kb)
|
Disorders & Mutations for FAAH
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602935 10/23 Novoseek disease relationships for FAAH gene (see all 23
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| miscarriage recurrent |
40.06 |
10 |
18805581 (6), 12744923 (1), 14580383 (1) |
| catalepsy |
34.71 |
1 |
16834756 (1) |
| spontaneous abortion |
30.78 |
4 |
11390466 (1), 15464041 (1), 18805581 (1), 15472222 (1) |
| motor disorder |
23.26 |
1 |
12505686 (1) |
| multiple sclerosis |
21.54 |
3 |
17329437 (1), 16596785 (1) |
| hyperalgesia |
20.40 |
1 |
17279090 (1) |
| glioma |
19.21 |
2 |
11118429 (1), 17325653 (1) |
| inflammation |
18.83 |
12 |
19184452 (2), 17434980 (1), 14561206 (1), 17949010 (1) (see all 8) |
| obesity |
16.86 |
10 |
18819056 (3), 18295974 (2), 17216208 (1), 18426509 (1) |
| neurological disorders |
14.84 |
5 |
17177441 (1), 15229230 (1), 16136230 (1) |
About this table
Human Gene Mutation Database: FAAH Genetic Association Database: FAAH Human Genome Epidemiology Navigator: FAAH (22 documents)
|
Medical News for FAAH(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FAAH (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/219 PubMed articles for FAAH gene (see all 219
):- Molecular characterization of human and mouse fatty acid amide hydrolases. (PubMed id 9122178)1, 2, 3, 4 Giang D.K. and Cravatt B.F. (1997)
- A missense mutation in human fatty acid amide hydrolase associated with problem drug use. (PubMed id 12060782)3, 4, 6 Sipe J.C.... Cravatt B.F. (2002)
- Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. (PubMed id 9878243)1, 3, 4 Wan M.... Francke U. (1998)
- A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. (PubMed id 15721218)1, 3, 6 Morita Y....Kuroda S. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). (PubMed id 15809662)3, 6 Sipe J.C....Beutler E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)3, 4 Gevaert K.... Vandekerckhove J. (2003)
- Expression and function of fatty acid amide hydrolase in prostate cancer. (PubMed id 18566995)1, 3 Endsley M.P....Nithipatikom K. (2008)
- Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing. (PubMed id 17991615)1, 3 Doehring A....Lotsch J. (2007)
|
Search for FAAH
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FAAH
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FAAH
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAAH(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/faah/ |
|
| | | About This Section
| --
| Services for FAAH(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FAAH:

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| Antibodies & Assays for FAAH  (FAAH1) |
| | Recombinant Proteins (FAAH) | | Antibodies (FAAH) |
| | | Tocris compounds for FAAH |
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