Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FAAH Gene

protein-coding   GIFtS: 67
GCID: GC01P046860

Fatty Acid Amide Hydrolase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fatty Acid Amide Hydrolase1 2     Fatty-Acid Amide Hydrolase 12
Anandamide Amidohydrolase 12 3     EC 3.5.1.993
Oleamide Hydrolase 12 3     FAAH13
FAAH-12     EC 3.5.18
PSAB2     EC 3.5.1.n28

External Ids:    HGNC: 35531   Entrez Gene: 21662   Ensembl: ENSG000001174807   OMIM: 6029355   UniProtKB: O005193   

Export aliases for FAAH gene to outside databases

Previous GC identifers: GC01P046501 GC01P045816 GC01P046246 GC01P046229 GC01P046572 GC01P046632 GC01P044975


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FAAH Gene:
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid
amides, including the neuromodulatory compounds anandamide and oleamide. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAAH Gene:
FAAH (fatty acid amide hydrolase) is a protein-coding gene. Diseases associated with FAAH include drug addiction, and autoimmune encephalitis. GO annotations related to this gene include fatty acid amide hydrolase activity and acylglycerol lipase activity. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic
amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates

summary for FAAH Gene:
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane
protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH
distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the
pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small
intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second
FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the FAAH gene promoter:
         Pax-5   MEF-2   HTF   Lmo2   Evi-1   MEF-2A   STAT3   aMEF-2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAAH promoter sequence
   Search Chromatin IP Primers for FAAH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p35-p34

FAAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAAH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046860:  view genomic region     (about GC identifiers)

Start:
46,859,937 bp from pter      End:
46,879,520 bp from pter
Size:
19,584 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519 (See protein sequence)
Recommended Name: Fatty-acid amide hydrolase 1  
Size: 579 amino acids; 63066 Da
Subunit: Homodimer (By similarity)
Secondary accessions: D3DQ19 Q52M86 Q5TDF8

Explore the universe of human proteins at neXtProt for FAAH: NX_O00519

Explore proteomics data for FAAH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for FAAH (O00519)
     DIGGSIR  GGSIRFP  ALPGASG 


    See FAAH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001432.2  
    ENSEMBL proteins: 
     ENSP00000243167  

    FAAH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FAAH
    OriGene Protein Over-expression Lysate for FAAH
    OriGene MassSpec for FAAH
    OriGene Custom Protein Services for FAAH
    GenScript Custom Purified and Recombinant Proteins Services for FAAH
    Novus Biologicals FAAH Protein
    Novus Biologicals FAAH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAAH

    FAAH Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FAAH
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for FAAH 
    OriGene Antibodies for FAAH
    OriGene Custom Antibody Services for FAAH
    Novus Biologicals FAAH Antibodies
    Abcam antibodies for FAAH
    Cloud-Clone Corp. Antibodies for FAAH
    ThermoFisher Antibodies for FAAH
    LSBio Antibodies in human, mouse, rat for FAAH

    FAAH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FAAH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FAAH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAAH
    Cloud-Clone Corp. CLIAs for FAAH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid amide hydrolase-1
    Endocannabinoid turnover

    4 InterPro protein domains:
     IPR020556 Amidase_CS
     IPR000120 Amidase
     IPR023631 Amidase_dom
     IPR015830 Amidase_fun

    Graphical View of Domain Structure for InterPro Entry O00519

    ProtoNet protein and cluster: O00519

    1 Blocks protein domain: IPB000120 Amidase

    UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
    Similarity: Belongs to the amidase family


    FAAH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAAH1_HUMAN, O00519
    Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic
    amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
    Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates
    Catalytic activity: Anandamide + H(2)O = arachidonic acid + ethanolamine
    Catalytic activity: Oleamide + H(2)O = oleic acid + NH(3)
    Enzyme regulation: Inhibited by O-aryl carbamates and alpha-keto heterocytes

         Genatlas biochemistry entry for FAAH:
    fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty
    acids such as oleamide and anandamide

         Enzyme Numbers (IUBMB): EC 3.5.1.991 EC 3.5.12 EC 3.5.1.n22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
    GO:0016884carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA--
    GO:0017064fatty acid amide hydrolase activity IDA9122178
    GO:0047372acylglycerol lipase activity IEA--
         
    FAAH for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FAAH:
     Decreased cilium length  Decreased cilium length after   Synthetic lethal with c-Myc af 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Faah):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  muscle 
     nervous system  normal 

    FAAH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FAAH: Faahtm1Lex Faahtm1Crv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAAH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAAH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAAH

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAAH:
    hsa-mir-423-5p (MIRT038079)

    Block miRNA regulation of human, mouse, rat FAAH using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAAH:
    hsa-miR-198 hsa-miR-943
    SwitchGear 3'UTR luciferase reporter plasmidFAAH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAAH
    Predesigned siRNA for gene silencing in human, mouse, rat FAAH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FAAH

    Clone
    Products:
         
    OriGene clones in human, mouse for FAAH (see all 6)
    OriGene ORF clones in mouse, rat for FAAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAAH (NM_001441)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FAAH
    Browse ESI BIO Cell Lines and PureStem Progenitors for FAAH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FAAH1_HUMAN, O00519: Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be
    attached to intracellular membranes and a portion of the cytoskeletal network
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    extracellular2
    peroxisome2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031090organelle membrane ISS--

    FAAH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FAAH About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    2phospholipases
    Anandamide biosynthesis and metabolism0.34
    3Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    4anandamide degradation
    anandamide degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FAAH
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for FAAH
        Anandamide biosynthesis and metabolism

    1 BioSystems Pathway for FAAH
        anandamide degradation


    1 Kegg Pathway  (Kegg details for FAAH):
        Retrograde endocannabinoid signaling


    FAAH for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FAAH: 
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FAAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for FAAH (O005193 ENSP000002431674) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PET112O758793, ENSP000002639854I2D: score=1 STRING: ENSP00000263985
    MMEP084733I2D: score=2 
    ACACBO007633I2D: score=1 
    CTU1Q7Z7A33I2D: score=1 
    CYC1P085743I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009062fatty acid catabolic process IDA9122178

    FAAH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FAAH
      Browse compounds at ApexBio 

    Compounds for FAAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SA 57Potent FAAH inhibitor[1346169-63-8]
    PF 3845Selective FAAH inhibitor[1196109-52-0]
    JNJ 1661010 Selective, reversible FAAH inhibitor [681136-29-8]
    TC-F 2 Potent, reversible and selective FAAH inhibitor [1304778-15-1]

    1 HMDB Compound for FAAH    About this table
    CompoundSynonyms CAS #PubMed Ids
    AnandamideAnandamide (20.4, n-6) (see all 13)94421-68-8--

    6 DrugBank Compounds for FAAH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Methoxy arachidonyl fluorophosphonate-- --target--17139284 17016423 10592235
    Propofol2,6-Diisopropylphenol (see all 2)2078-54-8enzymesubstrate19933260 10592235
    ThiopentalPenthiobarbital (see all 10)76-75-5targetinhibitor11752352 12839875
    1-DODECANOL-- --target--10592235
    4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid-- --target--10592235
    4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid-- --target--10592235

    5 IUPHAR Ligands for FAAH (Fatty acid amide hydrolase-1)    About this table
    LigandTypeActionAffinityPubmed IDs
    PF750
    InhibitorInhibition6.3 - 7.817949010
    JNJ1661010
    InhibitorInhibition7.818693015
    OL135
    InhibitorInhibition7.417015445
    URB597
    InhibitorInhibition6.3 - 717015445
    PF3845
    InhibitorInhibition6.619389627

    Selected Novoseek inferred chemical compound relationships for FAAH gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anandamide 96.8 337 11353795 (8), 11118429 (6), 17676056 (5), 10431820 (4) (see all 99)
    2-arachidonoylglycerol 94.2 88 11095952 (4), 18566995 (3), 18394720 (3), 15923084 (2) (see all 30)
    oleamide 93.7 48 10805767 (2), 17177441 (2), 11585048 (2), 17279740 (1) (see all 24)
    urb 597 92.8 37 18814866 (3), 17314320 (2), 16834756 (2), 17511970 (2) (see all 20)
    monoacylglycerol 89.6 52 17649977 (2), 18289091 (2), 17621164 (2), 16854070 (1) (see all 33)
    palmitoylethanolamide 89.5 23 11485574 (4), 11585048 (2), 10431820 (1), 10692582 (1) (see all 9)
    glyceryl arachidonate 81.7 1 16181610 (1)
    linoleoyl ethanolamide 79.8 1 9822713 (1)
    mafp 77.3 11 11118429 (3), 15910884 (1), 11353795 (1), 14718261 (1) (see all 5)
    rimonabant 73.9 3 19559363 (1), 19374636 (1), 16129456 (1)

    1 PharmGKB related drug/compound annotation for FAAH gene    About this table
    Drug/compound PharmGKB Annotation
    methamphetamineCA  



    FAAH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FAAH gene: 
    NM_001441.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243167(uc001cpu.2 uc001cpv.2) ENST00000468718 ENST00000493735
    ENST00000484697 ENST00000489366 ENST00000493636
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAAH using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAAH:
    hsa-miR-198 hsa-miR-943
    SwitchGear 3'UTR luciferase reporter plasmidFAAH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAAH
    Predesigned siRNA for gene silencing in human, mouse, rat FAAH
    Clone
    Products:
         
    OriGene clones in human, mouse for FAAH (see all 6)
    OriGene ORF clones in mouse, rat for FAAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAAH (NM_001441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAAH
    OriGene qSTAR qPCR primer pairs in human, mouse for FAAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAAH
      QuantiTect SYBR Green Assays in human, mouse, rat FAAH
      QuantiFast Probe-based Assays in human, mouse, rat FAAH

    Selected AceView cDNA sequences (see all 336):

    BX648592 BU171186 CB266514 AI275856 AL050372 BU785964 BX346286 BF726379 
    CD722946 AI951464 AL042018 AI274566 BF436906 CB049339 AI920966 AW955019 
    AI565253 AI167794 BI762645 BX111549 BM470538 NM_001441 Z38578 BQ424895 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FAAH    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                            -                             -                                             
    SP2:                                            -     -     -                 -                 -           -               
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for FAAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FAAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATGACAT
    FAAH Expression
    About this image

    FAAH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAAH Protein Expression

    UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
    Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also
    expressed in the kidney, liver, lung, placenta and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including FAAH: 
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAAH
    OriGene qSTAR qPCR primer pairs in human, mouse for FAAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAAH
    QuantiTect SYBR Green Assays in human, mouse, rat FAAH
    QuantiFast Probe-based Assays in human, mouse, rat FAAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAAH gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faah1 , 5 fatty acid amide hydrolase1, 5 84.05(n)1
    83.94(a)1
      4 (53.08 cM)5
    140731  NM_010173.41  NP_034303.31 
     1159671455 
    chicken
    (Gallus gallus)
    Aves FAAH1 fatty acid amide hydrolase 63.48(n)
    57.72(a)
      424614  XM_422450.4  XP_422450.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAAH6
    fatty acid amide hydrolase
    55(a)
    1 ↔ 1
    4(112195875-112227243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.113062 Xenopus laevis transcribed sequence with weak similarity more 71.61(n)    BX851598.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FAAH6
    fatty acid amide hydrolase
    50(a)
    1 ↔ 1
    6(3324243-3352911) ENSDARG00000077764
    fruit fly
    (Drosophila melanogaster)
    Insecta CG305023   -- 39(a)   43C3   --
    worm
    (Caenorhabditis elegans)
    Secernentea C25A1.53
    faah-11
    Yeast hypothetical 44.9 KD protein like3
    faah-11
    45(a)
    (best of 7)3
    45.58(n)1
    42.04(a)1
      I(10185243-10186628)3
    1776131  NM_068967.51  NP_501368.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AMD2(YDR242W)4 Putative amidase   --   4(946807-948456) 851829  NP_010528.1 


    ENSEMBL Gene Tree for FAAH (if available)
    TreeFam Gene Tree for FAAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FAAH gene
    FAAH22  
    1 SIMAP similar gene for FAAH using alignment to 1 protein entry:     FAAH1_HUMAN:
    DKFZp434A091

    FAAH for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAAH
    PGOHUM00000244703


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    FAAH1_HUMAN, O00519: Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse
    [MIM:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and
    methamphetamine dependence


    Selected SNPs for FAAH (see all 671)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357044
    A breast cancer sample4--see VAR_0357042 A D mis40--------
    rs3244201,2,,4
    C,F,O,A,Hother146948415(+) AGGCCC/ACAAGG 2 /T /P mis1 ese341Minor allele frequency- A:0.26EA NA MN NS WA CSA EU 9775
    rs19844911,2
    C,F,A--46858607(-) CAGGGA/CAGCAA 1 -- us2k16Minor allele frequency- C:0.20NS WA NA 424
    rs454498931,2
    C,F--46859024(+) TTTTCA/GCATTG 1 -- us2k17Minor allele frequency- G:0.20NS WA NA CSA 418
    rs455139921,2
    C,F--46859113(+) ACCTCC/TTCAGG 1 -- us2k12Minor allele frequency- T:0.03NS WA 292
    rs455178371,2
    C,F--46859225(+) CTCGAA/GTATAA 1 -- us2k16Minor allele frequency- G:0.20NS WA NA 420
    rs455795391,2
    C,F--46859282(+) GGGTGC/TGCCCT 1 -- us2k12Minor allele frequency- T:0.01NS NA 296
    rs112885111,2
    C--46862281(+) TTTTT-/GCCAAG 1 -- int10--------
    rs665069311,2
    C--46866715(+) AGGGA-/AAACCA 1 -- int10--------
    rs455162981,2
    C,F--46868833(+) AGTCTT/CGCTCT 1 -- int11Minor allele frequency- C:0.01NS 176

    HapMap Linkage Disequilibrium report for FAAH (46859937 - 46879520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAAH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829748CNV Loss17160897

    Human Gene Mutation Database (HGMD): FAAH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAAH
    DNA2.0 Custom Variant and Variant Library Synthesis for FAAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602935   
    OMIM disorders: 606581  
    Selected diseases for FAAH (see all 49):    
    About MalaCards
    drug addiction    autoimmune encephalitis    fatty acid hydroxylase-associated neurodegeneration    somatoform disorder
    cannabis dependence    back pain    pain agnosia    post-traumatic stress disorder
    ectopic pregnancy    bulimia nervosa    constipation    obesity, association with
    eating disorder    huntington's disease    agnosia    anorexia nervosa
    obesity    morbid obesity    multiple sclerosis    hyperglycemia

    2 diseases from the University of Copenhagen DISEASES database for FAAH:
    Pain agnosia     Cannabis dependence

    FAAH for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FAAH gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    miscarriage recurrent 36.8 10 18805581 (6), 12744923 (1), 14580383 (1)
    obesity 33.7 46 20044928 (7), 18819056 (3), 20065978 (2), 19958092 (2) (see all 11)
    catalepsy 31.6 1 16834756 (1)
    miscarriage 31.4 7 19419760 (3), 11390466 (1), 15464041 (1), 18805581 (1) (see all 5)
    inflammation 21.5 17 19184452 (2), 17434980 (1), 14561206 (1), 17949010 (1) (see all 10)
    multiple sclerosis 20.9 3 17329437 (1), 16596785 (1)
    motor disorder 19.7 1 12505686 (1)
    hyperalgesia 16.4 1 17279090 (1)
    anxiety depression 15.2 4 17217969 (1), 19850474 (1), 20462810 (1)
    glioma 15.1 2 11118429 (1), 17325653 (1)

    Genetic Association Database (GAD): FAAH
    Human Genome Epidemiology (HuGE) Navigator: FAAH (50 documents)

    Export disorders for FAAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FAAH gene, integrated from 10 sources (see all 338):
    (articles sorted by number of sources associating them with FAAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human and mouse fatty acid amide hydrolases. (PubMed id 9122178)1, 2, 3, 9 Giang D.K. and Cravatt B.F. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. (PubMed id 16972078)1, 2, 4, 9 Flanagan J.M....Sipe J.C. (Hum. Genet. 2006)
    3. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. (PubMed id 12060782)1, 2, 4 Sipe J.C.... Cravatt B.F. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PubMed id 20044928)1, 4, 9 MA1ller T.D....Hinney A. (BMC Med. Genet. 2010)
    5. Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. (PubMed id 9878243)1, 2, 9 Wan M.... Francke U. (Genomics 1998)
    6. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. (PubMed id 19165169)1, 4, 9 Lieb W....Fox C.S. (Obesity (Silver Spring) 2009)
    7. Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation. (PubMed id 17962356)1, 4, 9 Camilleri M....Zinsmeister A.R. (Am. J. Physiol. Gastrointest. Liver Physiol. 2008)
    8. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PubMed id 20010914)1, 4, 9 Proudnikov D....Kreek M.J. (Pharmacogenomics J. 2010)
    9. [C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and adipocytokine levels in the morbidly obese]. (PubMed id 20189896)1, 4, 9 De Luis D.A....Romero E. (Endocrinol Nutr 2010)
    10. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. (PubMed id 15721218)1, 4, 9 Morita Y....Kuroda S. (Neurosci. Lett. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2166 HGNC: 3553 AceView: FAAHandNSUN4 Ensembl:ENSG00000117480 euGenes: HUgn2166
    ECgene: FAAH Kegg: 2166 H-InvDB: FAAH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FAAH Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/faah/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FAAH gene:
    Search GeneIP for patents involving FAAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of FAAH
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FAAH   OriGene RNAi products in human, mouse, rat for FAAH  
     OriGene qPCR primer pairs and template standards for FAAH   OriGene Protein Over-expression Lysate for FAAH  
     OriGene MassSpec something-or-other for FAAH   OriGene clones in human, mouse for FAAH  
     OriGene qSTAR qPCR primer pairs in human, mouse for FAAH   OriGene Purified Protein for FAAH  
     OriGene ORF clones in mouse, rat for FAAH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FAAH   OriGene Custom Protein Services for FAAH  

     
     
     Block miRNA regulation of human, mouse, rat FAAH using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FAAH
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAAH Predesigned siRNA for gene silencing in human, mouse, rat FAAH
     QuantiFast Probe-based Assays in human, mouse, rat FAAH QuantiTect SYBR Green Assays in human, mouse, rat FAAH
     PCR Arrays including human, mouse, rat FAAH Search Chromatin IP Primers for FAAH
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAAH  GeneGlobe Interaction Network for FAAH
     Regulatory tfbs in FAAH promoter
     GenScript Custom Purified and Recombinant Proteins Services for FAAH GenScript cDNA clones with any tag delivered in your preferred vector for FAAH
     GenScript Custom Assay Services for FAAH GenScript Custom overexpressing Cell Line Services for FAAH
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FAAH 

     Tocris compounds for FAAH
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for FAAH
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FAAH antibodies
     FAAH proteins
     FAAH lysates
     Antibodies for FAAH
     See all of Abcam's Antibodies, Kits and Proteins for FAAH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FAAH
     Antibodies for FAAH
     ELISAs for FAAH
     CLIAs for FAAH



     Browse ESI BIO Cell Lines and PureStem Progenitors for FAAH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH
     SwitchGear 3'UTR luciferase reporter plasmids for FAAH
     SwitchGear Promoter luciferase reporter plasmids for FAAH
     ThermoFisher Antibodies for FAAH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAAH
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAAH
     LSBio Antibodies in human, mouse, rat for FAAH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FAAH gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4