FAAH Gene
protein-coding GIFtS: 65
GCID: GC01P046860
|
|
fatty acid amide hydrolase
| |
Aliases
for FAAH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fatty Acid Amide Hydrolase1 2 | | EC 3.5.1.993 | | FAAH-11 2 | | FAAH13 | | Anandamide Amidohydrolase 12 3 | | EC 3.5.18 | | Oleamide Hydrolase 12 3 | | EC 3.5.1.N21 | | Fatty-Acid Amide Hydrolase 12 | | |
Export aliases for FAAH gene to outside databasesPrevious GC identifers: GC01P046501 GC01P045816 GC01P046246 GC01P046229 GC01P046572 GC01P046632 GC01P044975 |
Summaries
for FAAH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FAAH:
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acidamides, including the neuromodulatory compounds anandamide and oleamide. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amideto their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzespolyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates
 summary
for FAAH: Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane
protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH
distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the
pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small
intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second
FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.
|
Genomic Views
for FAAH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAAH gene promoter:
Pax-5 MEF-2 HTF Lmo2 Evi-1 MEF-2A STAT3 aMEF-2 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAAH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAAH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35-p34 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p35-p34FAAH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P046860: view genomic region
(about GC identifiers)
Start:
|
46,859,937 bp from pter |
End:
|
46,879,520 bp from pter |
Size:
|
19,584 bases |
Orientation:
|
plus strand |
|
Proteins
for FAAH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519 (See
protein sequence)Recommended Name: Fatty-acid amide hydrolase 1 Size: 579 amino acids; 63066 Da
Subunit: Homodimer (By similarity)
Subcellular location: Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to beattached to intracellular membranes and a portion of the cytoskeletal network
Secondary accessions: D3DQ19 Q52M86 Q5TDF8Explore the universe of human proteins at neXtProt for FAAH: NX_O00519
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00519
3 DME Specific Peptides for FAAH (O00519)
FAAH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001432.2
ENSEMBL proteins: ENSP00000243167
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
FAAH for ontologies About GeneDecksing
FAAH Antibody Products:
Assay Products for FAAH: |
Protein
Domains /
Families
for FAAH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAAH for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00519ProtoNet protein and cluster: O00519 1 Blocks protein family: IPB000120 Amidase
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Similarity: Belongs to the amidase family |
Function
for FAAH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amideto their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzespolyunsaturated substrate anandamide preferentially as compared to monounsaturated substratesCatalytic activity: Anandamide + H(2)O = arachidonic acid + ethanolamineCatalytic activity: Oleamide + H(2)O = oleic acid + NH(3)Enzyme regulation: Inhibited by O-aryl carbamates and alpha-keto heterocytes Genatlas biochemistry entry for FAAH:fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acidssuch as oleamide and anandamide
Enzyme Numbers (IUBMB): EC 3.5.1.991 EC 3.5.12 EC 3.5.1.n22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAAH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAAH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAAH (NM_001441) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAAH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004040 | amidase activity |
-- | -- | | GO:0005543 | phospholipid binding |
-- | -- | | GO:0008289 | lipid binding |
-- | -- | | GO:0016788 | hydrolase activity, acting on ester bonds |
-- | -- | | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
IEA | -- |
FAAH for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for FAAH:
Animal Models:
Mouse knock-outs for FAAH: Faahtm1Lex Faahtm1Crv
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Faah):
FAAH for phenotypes About GeneDecksing
|
Pathways & Interactions
for FAAH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Acyl chain remodelling of PE | | | 2 | anandamide degradation | | | 3 | Glucose / Energy Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for FAAH
1 
Cell Signaling Technology (CST) Pathway for FAAH
1  GeneGo (Thomson Reuters) Pathway for FAAH
1  BioSystems Pathway for FAAH
FAAH for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FAAH
5/16 Interacting proteins for FAAH (O005193) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009062 | fatty acid catabolic process |
IDA | 9122178 |
FAAH for ontologies About GeneDecksing
|
Drugs & Compounds
for FAAH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FAAH for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for FAAH |
Compounds for FAAH available from Tocris Bioscience About this table
1 HMDB Compound for FAAH About this table
6 DrugBank Compounds for FAAH About this table
10/39 Novoseek chemical compound relationships for FAAH gene (see all 39) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| anandamide |
96.8 |
337 |
11353795 (8), 11118429 (6), 17676056 (5), 10431820 (4) (see all 99) |
| 2-arachidonoylglycerol |
94.2 |
88 |
11095952 (4), 18566995 (3), 18394720 (3), 15923084 (2) (see all 30) |
| oleamide |
93.7 |
48 |
10805767 (2), 17177441 (2), 11585048 (2), 17279740 (1) (see all 24) |
| urb 597 |
92.8 |
37 |
18814866 (3), 17314320 (2), 16834756 (2), 17511970 (2) (see all 20) |
| monoacylglycerol |
89.6 |
52 |
17649977 (2), 18289091 (2), 17621164 (2), 16854070 (1) (see all 33) |
| palmitoylethanolamide |
89.5 |
23 |
11485574 (4), 11585048 (2), 10431820 (1), 10692582 (1) (see all 9) |
| glyceryl arachidonate |
81.7 |
1 |
16181610 (1) |
| linoleoyl ethanolamide |
79.8 |
1 |
9822713 (1) |
| mafp |
77.3 |
11 |
11118429 (3), 15910884 (1), 11353795 (1), 14718261 (1) (see all 5) |
| rimonabant |
73.9 |
3 |
19559363 (1), 19374636 (1), 16129456 (1) |
Search CenterWatch for drugs/clinical trials and news about FAAH / FAAH1
|
Transcripts
for FAAH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAAH gene: NM_001441.2 Unigene Cluster for FAAH: Fatty acid amide hydrolase Hs.720143 [show with all ESTs]Unigene Representative Sequence: NM_0014416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000243167(uc001cpu.2 uc001cpv.2) ENST00000468718 ENST00000493735
ENST00000484697 ENST00000489366 ENST00000493636
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAAH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAAH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAAH (NM_001441) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAAH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH |
Additional cDNA sequence: AL050372.1 BC034478.1 BC093632.1 BC110404.1 BC111941.1 U82535.1 11 DOTS entries: DT.313625 DT.91741626 DT.121326323 DT.87016642 DT.121326472 DT.95332161 DT.95332175 DT.121326446 DT.91685857 DT.121326505 DT.121326373 24/336 AceView cDNA sequences (see all 336): CR620787 BQ424895 BQ014732 CA502993 AI565253 AL042404 BF726379 AK128066 AI686717 AK021577 AI920966 CA395976 AA887288 CF529182 U82535 BU171186 AI375665 CB049339 BF913261 NM_199044 AW273419 BI762645 CD722946 AI951464
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for FAAH About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FAAH
|
Expression
for FAAH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAAH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTATGACAT
About this image
See FAAH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAAH
SOURCE GeneReport for Unigene cluster: Hs.720143
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Alsoexpressed in the kidney, liver, lung, placenta and prostate
SABiosciences Expression via Pathway-Focused PCR Array including FAAH:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAAH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAAH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAAH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAAH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH |
Orthologs
for FAAH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FAAH gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FAAH1 |
fatty acid amide hydrolase |
63.32(n)
57.27(a) |
|
424614 XM_422450.3 XP_422450.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FAAH6 |
-- |
56(a) |
1 ↔ 1 |
4(112196096-112226198) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.113062 |
Xenopus laevis transcribed sequence with weak similarity more |
71.61(n) |
|
BX851598.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:zfos-1404b8.26 |
si:zfos-1404b8.2 |
50(a) |
1 ↔ 1 |
6(3324243-3352911) |
worm
(Caenorhabditis elegans) |
Secernentea |
C25A1.53 |
Yeast hypothetical 44.9 KD protein like |
45(a)
(best of 7) |
|
I(10185243-10186628) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G073606 |
Amidase family protein |
12(a) |
possible ortholog |
5(2326704-2330142) |
rice
(Oryza sativa) |
Liliopsida |
-- |
amidase, putative, expressed |
11(a) |
possible ortholog |
11(19106088-19110227) |
ENSEMBL Gene Tree for FAAH (if available)
TreeFam Gene Tree for FAAH (if available) |
Paralogs
for FAAH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAAH gene
- FAAH22
1 SIMAP similar gene for FAAH using alignment to 1 protein entry: FAAH1_HUMAN:DKFZp434A091
FAAH for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FAAH
PGOHUM00000244703
|
Genomic Variants
for FAAH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519Polymorphism: Variant Thr-129 seems to be strongly associated with illegal drug use and dependence. This variantdisplays normal catalytic properties but an enhanced sensitivity to proteolytic degradation
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAAH (46859937 - 46879520 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAAH: --
Human Gene Mutation Database (HGMD): FAAH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAAH |
|
Disorders
/ Diseases
for FAAH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAAH for disorders About GeneDecksing
OMIM gene information: 602935
OMIM disorders: --
20/42  diseases for FAAH (see all 42): About MalaCardsdrug addiction back pain cannabis dependence bulimia nervosa
somatoform disorder spontaneous abortion anorexia nervosa eating disorder
inflammatory bowel disease multiple sclerosis huntington's disease insulin resistance
bipolar disorder constipation diabetes mellitus alzheimer's disease
rheumatoid arthritis down syndrome neurodegenerative disease obesity, association with
10/23 Novoseek disease relationships for FAAH gene (see all 23) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| miscarriage recurrent |
36.8 |
10 |
18805581 (6), 12744923 (1), 14580383 (1) |
| obesity |
33.7 |
46 |
20044928 (7), 18819056 (3), 20065978 (2), 19958092 (2) (see all 11) |
| catalepsy |
31.6 |
1 |
16834756 (1) |
| miscarriage |
31.4 |
7 |
19419760 (3), 11390466 (1), 15464041 (1), 18805581 (1) (see all 5) |
| inflammation |
21.5 |
17 |
19184452 (2), 17434980 (1), 14561206 (1), 17949010 (1) (see all 10) |
| multiple sclerosis |
20.9 |
3 |
17329437 (1), 16596785 (1) |
| motor disorder |
19.7 |
1 |
12505686 (1) |
| hyperalgesia |
16.4 |
1 |
17279090 (1) |
| anxiety depression |
15.2 |
4 |
17217969 (1), 19850474 (1), 20462810 (1) |
| glioma |
15.1 |
2 |
11118429 (1), 17325653 (1) |
Genetic Association Database (GAD): FAAH
Human Genome Epidemiology (HuGE) Navigator: FAAH (50 documents)
Export disorders for FAAH gene to outside databases
|
Publications
for FAAH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAAH gene, integrated from 9 sources (see all 329):
(articles sorted by number of sources associating them with FAAH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization of human and mouse fatty acid amide hydrolases. (PubMed id 9122178)1, 2, 3, 9 Giang D.K. and Cravatt B.F. (1997)
- A missense mutation in human fatty acid amide hydrolase associated with problem drug use. (PubMed id 12060782)1, 2, 4 Sipe J.C.... Cravatt B.F. (2002)
- Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. (PubMed id 9878243)1, 2, 9 Wan M.... Francke U. (1998)
- A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. (PubMed id 15721218)1, 4, 9 Morita Y....Kuroda S. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). (PubMed id 15809662)1, 4 Sipe J.C....Beutler E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PubMed id 20044928)1, 9 MA1ller T.D....Hinney A. (2010)
- Expression and function of fatty acid amide hydrolase in prostate cancer. (PubMed id 18566995)1, 9 Endsley M.P....Nithipatikom K. (2008)
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External Searches for FAAH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing FAAH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing FAAH gene
(According to HUGE)
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Specialized Databases showing FAAH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for FAAH | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/faah/ |
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About This Section
| Patent Information for FAAH gene:
Search GeneIP for patents involving FAAH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FAAH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for FAAH | | OriGene shRNA RFP for FAAH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAAH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAAH | | | OriGene Protein Over-expression Lysate for FAAH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAAH | | OriGene 3'-UTR Clone for FAAH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAAH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAAH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FAAH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAAH | | OriGene Custom Protein Services for FAAH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAAH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAAH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAAH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAAH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAAH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAAH |
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| | Antibodies & Assays for FAAH |
| | | | Tocris compounds for FAAH |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH |
|  |  |  | | | | ThermoFisher Antibodies for FAAH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAAH |
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