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Aliases for FAAH Gene

Aliases for FAAH Gene

  • Fatty Acid Amide Hydrolase 2 3
  • Anandamide Amidohydrolase 1 3 4
  • Oleamide Hydrolase 1 3 4
  • Fatty-Acid Amide Hydrolase 1 3
  • EC 3.5.1.n2 63
  • EC 3.5.1.99 4
  • EC 3.5.1 63
  • FAAH-1 3
  • FAAH1 4
  • PSAB 3

External Ids for FAAH Gene

Previous GeneCards Identifiers for FAAH Gene

  • GC01P046501
  • GC01P045816
  • GC01P046246
  • GC01P046229
  • GC01P046572
  • GC01P046632
  • GC01P046860
  • GC01P044975

Summaries for FAAH Gene

Entrez Gene Summary for FAAH Gene

  • This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAAH Gene

FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include drug addiction and spastic paraplegia 35, autosomal recessive. Among its related pathways are Glucose / Energy Metabolism and Circadian entrainment. GO annotations related to this gene include acylglycerol lipase activity and fatty acid amide hydrolase activity. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot for FAAH Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Tocris Summary for FAAH Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH Gene

Genomics for FAAH Gene

Regulatory Elements for FAAH Gene

Genomic Location for FAAH Gene

Start:
46,394,265 bp from pter
End:
46,413,848 bp from pter
Size:
19,584 bases
Orientation:
Plus strand

Genomic View for FAAH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH Gene

Proteins for FAAH Gene

  • Protein details for FAAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00519-FAAH1_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 1
    Protein Accession:
    O00519
    Secondary Accessions:
    • D3DQ19
    • Q52M86
    • Q5TDF8

    Protein attributes for FAAH Gene

    Size:
    579 amino acids
    Molecular mass:
    63066 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH Gene

Proteomics data for FAAH Gene at MOPED

Selected DME Specific Peptides for FAAH Gene

Post-translational modifications for FAAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FAAH Gene

Gene Families for FAAH Gene

Protein Domains for FAAH Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAAH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00519

UniProtKB/Swiss-Prot:

FAAH1_HUMAN :
  • O00519
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH: view

Function for FAAH Gene

Molecular function for FAAH Gene

GENATLAS Biochemistry: fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acids such as oleamide and anandamide
UniProtKB/Swiss-Prot CatalyticActivity: Anandamide + H(2)O = arachidonic acid + ethanolamine
UniProtKB/Swiss-Prot CatalyticActivity: Oleamide + H(2)O = oleic acid + NH(3)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH Gene

Gene Ontology (GO) - Molecular Function for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA --
GO:0017064 fatty acid amide hydrolase activity IDA 9122178
GO:0047372 acylglycerol lipase activity IEA --
genes like me logo Genes that share ontologies with FAAH: view
genes like me logo Genes that share phenotypes with FAAH: view

Animal Models for FAAH Gene

MGI Knock Outs for FAAH:

miRNA for FAAH Gene

miRTarBase miRNAs that target FAAH

No data available for Transcription Factor Targeting and HOMER Transcription for FAAH Gene

Localization for FAAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH Gene

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAAH Gene COMPARTMENTS Subcellular localization image for FAAH gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 2
peroxisome 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane ISS --
genes like me logo Genes that share ontologies with FAAH: view

Pathways for FAAH Gene

genes like me logo Genes that share pathways with FAAH: view

Pathways by source for FAAH Gene

1 Cell Signaling Technology pathway for FAAH Gene
1 BioSystems pathway for FAAH Gene
1 KEGG pathway for FAAH Gene
1 GeneGo (Thomson Reuters) pathway for FAAH Gene

Gene Ontology (GO) - Biological Process for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process IDA 9122178
genes like me logo Genes that share ontologies with FAAH: view

Compounds for FAAH Gene

(5) Tocris Compounds for FAAH Gene

Compound Action Cas Number
JNJ 1661010 Selective, reversible FAAH inhibitor [681136-29-8]
JZL 195 Dual FAAH and MAGL inhibitor [1210004-12-8]
PF 3845 Selective FAAH inhibitor [1196109-52-0]
SA 57 Potent FAAH inhibitor [1346169-63-8]
URB 597 Potent and selective FAAH inhibitor [546141-08-6]

(1) HMDB Compounds for FAAH Gene

Compound Synonyms Cas Number PubMed IDs
Anandamide
  • Anandamide (20.4, n-6)
94421-68-8

(6) Drugbank Compounds for FAAH Gene

(5) IUPHAR Ligand for FAAH Gene

Ligand Type Action Affinity Pubmed IDs
PF750 Inhibitor Inhibition 7.8
JNJ1661010 Inhibitor Inhibition 7.8
OL135 Inhibitor Inhibition 7.4
PF3845 Inhibitor Inhibition 6.6
URB597 Activator Agonist 4.6

(39) Novoseek inferred chemical compound relationships for FAAH Gene

Compound -log(P) Hits PubMed IDs
anandamide 96.8 177
2-arachidonoylglycerol 94.2 41
oleamide 93.7 27
urb 597 92.8 25
monoacylglycerol 89.6 36

(7) PharmGKB related drug/compound annotations for FAAH Gene

Drug/compound Annotation
aripiprazole CA
clozapine CA
haloperidol CA
methamphetamine CA
olanzapine CA
quetiapine CA
risperidone CA
genes like me logo Genes that share compounds with FAAH: view

Transcripts for FAAH Gene

Unigene Clusters for FAAH Gene

Fatty acid amide hydrolase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for FAAH Gene

GeneLoc Exon Structure for
FAAH
ECgene alternative splicing isoforms for
FAAH

Expression for FAAH Gene

mRNA expression in normal human tissues for FAAH Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAAH Gene

SOURCE GeneReport for Unigene cluster for FAAH Gene Hs.720143

mRNA Expression by UniProt/SwissProt for FAAH Gene

O00519-FAAH1_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.
genes like me logo Genes that share expressions with FAAH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FAAH Gene

Orthologs for FAAH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAAH 35
  • 99.42 (n)
  • 99.31 (a)
FAAH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAAH 35
  • 87.51 (n)
  • 85.15 (a)
FAAH 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAAH 35
  • 89.41 (n)
  • 88.43 (a)
FAAH 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faah 35
  • 84.05 (n)
  • 83.94 (a)
Faah 16
Faah 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAAH 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faah 35
  • 84.23 (n)
  • 82.73 (a)
chicken
(Gallus gallus)
Aves FAAH 35
  • 63.48 (n)
  • 57.72 (a)
FAAH 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAAH 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11306 35
zebrafish
(Danio rerio)
Actinopterygii FAAH 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5191 36
  • 20 (a)
ManyToMany
CG30502 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea faah-1 35
  • 45.58 (n)
  • 42.04 (a)
faah-1 36
  • 37 (a)
OneToMany
faah-2 36
  • 34 (a)
OneToMany
faah-3 36
  • 32 (a)
OneToMany
C25A1.5 37
  • 45 (a)
Y56A3A.12b 37
  • 31 (a)
B0218.2 37
  • 35 (a)
Y56A3A.5 37
  • 30 (a)
F58H7.2 37
  • 35 (a)
Y56A3A.12a 37
  • 31 (a)
Y41C4A.2 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 36
  • 25 (a)
OneToMany
AMD2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU08356 35
  • 45.26 (n)
  • 34.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
Species with no ortholog for FAAH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAAH Gene

ENSEMBL:
Gene Tree for FAAH (if available)
TreeFam:
Gene Tree for FAAH (if available)

Paralogs for FAAH Gene

Paralogs for FAAH Gene

Selected SIMAP similar genes for FAAH Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAAH Gene

genes like me logo Genes that share paralogs with FAAH: view

Variants for FAAH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH Gene

O00519-FAAH1_HUMAN
Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and methamphetamine dependence

Sequence variations from dbSNP and Humsavar for FAAH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs324415 -- 46,392,457(-) gccgg(C/T)ggatc upstream-variant-2KB
rs324416 -- 46,399,715(+) AATGA(A/G)AACAA intron-variant
rs324417 -- 46,397,529(-) CCCCC(A/C/G)CAAAG intron-variant
rs324418 -- 46,407,026(-) CAAAA(C/T)GTGGA intron-variant
rs324420 other, - 46,405,089(+) AGGCC(A/C)CAAGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FAAH Gene

Variant ID Type Subtype PubMed ID
nsv829748 CNV Loss 17160897

Relevant External Links for FAAH Gene

HapMap Linkage Disequilibrium report
FAAH
Human Gene Mutation Database (HGMD)
FAAH

Disorders for FAAH Gene

(1) OMIM Diseases for FAAH Gene (602935)

(2) University of Copenhagen DISEASES for FAAH Gene

(23) Novoseek inferred disease relationships for FAAH Gene

Disease -log(P) Hits PubMed IDs
miscarriage recurrent 36.8 8
obesity 33.7 24
catalepsy 31.6 1
miscarriage 31.4 7
inflammation 21.5 11

Relevant External Links for FAAH

Genetic Association Database (GAD)
FAAH
Human Genome Epidemiology (HuGE) Navigator
FAAH
genes like me logo Genes that share disorders with FAAH: view

No data available for UniProtKB/Swiss-Prot for FAAH Gene

Publications for FAAH Gene

  1. Molecular characterization of human and mouse fatty acid amide hydrolases. (PMID: 9122178) Giang D.K. … Cravatt B.F. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. (PMID: 16972078) Flanagan J.M. … Sipe J.C. (Hum. Genet. 2006) 3 4 23 48
  3. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. (PMID: 15254019) Chiang K.P. … Cravatt B.F. (Hum. Mol. Genet. 2004) 3 4 23
  4. The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites. (PMID: 17216208) Jensen D.P. … Pedersen O. (J. Mol. Med. 2007) 3 23 48
  5. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. (PMID: 15721218) Morita Y. … Kuroda S. (Neurosci. Lett. 2005) 3 23 48

Products for FAAH Gene

Sources for FAAH Gene

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