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Aliases for FAAH Gene

Aliases for FAAH Gene

  • Fatty Acid Amide Hydrolase 2 3 5
  • Anandamide Amidohydrolase 1 3 4
  • Oleamide Hydrolase 1 3 4
  • EC 3.5.1.n2 63
  • EC 3.5.1.99 4
  • EC 3.5.1 63
  • FAAH-1 3
  • FAAH1 4
  • PSAB 3

External Ids for FAAH Gene

Previous GeneCards Identifiers for FAAH Gene

  • GC01P046501
  • GC01P045816
  • GC01P046246
  • GC01P046229
  • GC01P046572
  • GC01P046632
  • GC01P046860
  • GC01P044975

Summaries for FAAH Gene

Entrez Gene Summary for FAAH Gene

  • This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAAH Gene

FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include Drug Addiction and Spastic Paraplegia 35, Autosomal Recessive. Among its related pathways are Glucose / Energy Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot for FAAH Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Tocris Summary for FAAH Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH Gene

Genomics for FAAH Gene

Regulatory Elements for FAAH Gene

Enhancers for FAAH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAAH on UCSC Golden Path with GeneCards custom track

Promoters for FAAH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAAH on UCSC Golden Path with GeneCards custom track

Genomic Location for FAAH Gene

Chromosome:
1
Start:
46,394,265 bp from pter
End:
46,413,848 bp from pter
Size:
19,584 bases
Orientation:
Plus strand

Genomic View for FAAH Gene

Genes around FAAH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH Gene

Proteins for FAAH Gene

  • Protein details for FAAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00519-FAAH1_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 1
    Protein Accession:
    O00519
    Secondary Accessions:
    • D3DQ19
    • Q52M86
    • Q5TDF8

    Protein attributes for FAAH Gene

    Size:
    579 amino acids
    Molecular mass:
    63066 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH Gene

Proteomics data for FAAH Gene at MOPED

Selected DME Specific Peptides for FAAH Gene

Post-translational modifications for FAAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FAAH (FAAH)

Domains & Families for FAAH Gene

Gene Families for FAAH Gene

Protein Domains for FAAH Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FAAH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00519

UniProtKB/Swiss-Prot:

FAAH1_HUMAN :
  • Belongs to the amidase family.
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH: view

Function for FAAH Gene

Molecular function for FAAH Gene

GENATLAS Biochemistry:
fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acids such as oleamide and anandamide
UniProtKB/Swiss-Prot CatalyticActivity:
Anandamide + H(2)O = arachidonic acid + ethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleamide + H(2)O = oleic acid + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH Gene

Gene Ontology (GO) - Molecular Function for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017064 fatty acid amide hydrolase activity IDA,TAS --
genes like me logo Genes that share ontologies with FAAH: view
genes like me logo Genes that share phenotypes with FAAH: view

Animal Models for FAAH Gene

MGI Knock Outs for FAAH:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAAH

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAAH Gene

Localization for FAAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH Gene

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAAH Gene COMPARTMENTS Subcellular localization image for FAAH gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 3
extracellular 3
lysosome 2
plasma membrane 2
vacuole 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane ISS --
genes like me logo Genes that share ontologies with FAAH: view

Pathways & Interactions for FAAH Gene

genes like me logo Genes that share pathways with FAAH: view

Pathways by source for FAAH Gene

1 Cell Signaling Technology pathway for FAAH Gene
1 BioSystems pathway for FAAH Gene
1 PharmGKB pathway for FAAH Gene
1 KEGG pathway for FAAH Gene
1 GeneGo (Thomson Reuters) pathway for FAAH Gene

Gene Ontology (GO) - Biological Process for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process IDA 9122178
genes like me logo Genes that share ontologies with FAAH: view

No data available for SIGNOR curated interactions for FAAH Gene

Drugs & Compounds for FAAH Gene

(48) Drugs for FAAH Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiopental Approved Pharma Target, inhibitor 32
Propofol Approved, Investigational Pharma Enzyme, substrate 962
Aripiprazole Approved, Investigational Pharma Antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 343
Clozapine Approved Pharma Antagonist Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Haloperidol Approved Pharma Antagonist Antipsychotic drug 136

(25) Additional Compounds for FAAH Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxypropofol
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Aacocf3
149301-79-1
Arachidonyl serotonin
187947-37-1

(5) Tocris Compounds for FAAH Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Arachidonyl serotonin Dual FAAH inhibitor/TRPV1 antagonist 187947-37-1
LY 2183240 Novel, potent anandamide uptake inhibitor; inhibits FAAH 874902-19-9
Palmitoylisopropylamide Inhibitor of FAAH 189939-61-5
PDP-EA FAAH activator 861891-72-7

(3) ApexBio Compounds for FAAH Gene

Compound Action Cas Number
JNJ-1661010 FAAH inhibitor,potent and selective 681136-29-8
PF-3845 FAAH ihibitor,highly potent and selective 1196109-52-0
URB597 FAAH inhibitor,potent and selective 546141-08-6
genes like me logo Genes that share compounds with FAAH: view

Drug Products

Transcripts for FAAH Gene

Unigene Clusters for FAAH Gene

Fatty acid amide hydrolase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for FAAH Gene

GeneLoc Exon Structure for
FAAH
ECgene alternative splicing isoforms for
FAAH

Expression for FAAH Gene

mRNA expression in normal human tissues for FAAH Gene

Protein differential expression in normal tissues from HIPED for FAAH Gene

This gene is overexpressed in Testis (18.9), Islet of Langerhans (7.9), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAAH Gene



SOURCE GeneReport for Unigene cluster for FAAH Gene Hs.720143

mRNA Expression by UniProt/SwissProt for FAAH Gene

O00519-FAAH1_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.
genes like me logo Genes that share expression patterns with FAAH: view

Protein tissue co-expression partners for FAAH Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FAAH Gene

Orthologs for FAAH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAAH 35
  • 87.51 (n)
  • 85.15 (a)
FAAH 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAAH 35
  • 89.41 (n)
  • 88.43 (a)
FAAH 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Faah 35
  • 84.05 (n)
  • 83.94 (a)
Faah 16
Faah 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAAH 35
  • 99.42 (n)
  • 99.31 (a)
FAAH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faah 35
  • 84.23 (n)
  • 82.73 (a)
oppossum
(Monodelphis domestica)
Mammalia FAAH 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAAH 35
  • 63.48 (n)
  • 57.72 (a)
FAAH 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAAH 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11306 35
zebrafish
(Danio rerio)
Actinopterygii FAAH 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30502 37
  • 39 (a)
CG5191 36
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0218.2 37
  • 35 (a)
C25A1.5 37
  • 45 (a)
F58H7.2 37
  • 35 (a)
Y41C4A.2 37
  • 28 (a)
Y56A3A.12a 37
  • 31 (a)
Y56A3A.12b 37
  • 31 (a)
Y56A3A.5 37
  • 30 (a)
faah-1 35
  • 45.58 (n)
  • 42.04 (a)
faah-1 36
  • 37 (a)
OneToMany
faah-2 36
  • 34 (a)
OneToMany
faah-3 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 36
  • 25 (a)
OneToMany
AMD2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU08356 35
  • 45.26 (n)
  • 34.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
Species with no ortholog for FAAH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAAH Gene

ENSEMBL:
Gene Tree for FAAH (if available)
TreeFam:
Gene Tree for FAAH (if available)

Paralogs for FAAH Gene

Paralogs for FAAH Gene

(1) SIMAP similar genes for FAAH Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAAH Gene

genes like me logo Genes that share paralogs with FAAH: view

Variants for FAAH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH Gene

FAAH1_HUMAN-O00519
Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and methamphetamine dependence.

Sequence variations from dbSNP and Humsavar for FAAH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs324420 - 46,405,089(+) AGGCC(A/C)CAAGG reference, missense
VAR_035704 A breast cancer sample
rs324415 -- 46,392,457(-) gccgg(C/T)ggatc upstream-variant-2KB
rs324416 -- 46,399,715(+) AATGA(A/G)AACAA intron-variant
rs324417 -- 46,397,529(-) CCCCC(A/C/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH Gene

Variant ID Type Subtype PubMed ID
nsv829748 CNV Loss 17160897

Variation tolerance for FAAH Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAAH Gene

Human Gene Mutation Database (HGMD)
FAAH

Disorders for FAAH Gene

MalaCards: The human disease database

(9) MalaCards diseases for FAAH Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
drug addiction
  • substance dependence
spastic paraplegia 35, autosomal recessive
  • fatty acid hydroxylase-associated neurodegeneration
autoimmune encephalitis
  • hashimoto's encephalitis
cannabis dependence
  • marijuana abuse
hallucinogen dependence
- elite association - COSMIC cancer census association via MalaCards
Search FAAH in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAAH

Genetic Association Database (GAD)
FAAH
Human Genome Epidemiology (HuGE) Navigator
FAAH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAAH
genes like me logo Genes that share disorders with FAAH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH Gene

Publications for FAAH Gene

  1. Molecular characterization of human and mouse fatty acid amide hydrolases. (PMID: 9122178) Giang D.K. … Cravatt B.F. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PMID: 20010914) Proudnikov D. … Kreek M.J. (Pharmacogenomics J. 2010) 3 23
  3. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PMID: 20044928) MA1ller T.D. … Hinney A. (BMC Med. Genet. 2010) 3 23
  4. C358A missense polymorphism of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) and visfatin levels in obese females. (PMID: 20065978) de Luis D.A. … Romero E. (Int J Obes (Lond) 2010) 3 23
  5. Biomarkers of endocannabinoid system activation in severe obesity. (PMID: 20098695) Sipe J.C. … Waalen J. (PLoS ONE 2010) 3 23

Products for FAAH Gene

Sources for FAAH Gene

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