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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAAH Gene

protein-coding   GIFtS: 69
GCID: GC01P046860

Fatty Acid Amide Hydrolase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fatty Acid Amide Hydrolase1 2     EC 3.5.1.993
Anandamide Amidohydrolase 12 3     FAAH13
Oleamide Hydrolase 12 3     EC 3.5.18
FAAH-12     EC 3.5.1.n28
Fatty-Acid Amide Hydrolase 12     

External Ids:    HGNC: 35531   Entrez Gene: 21662   Ensembl: ENSG000001174807   OMIM: 6029355   UniProtKB: O005193   

Export aliases for FAAH gene to outside databases

Previous GC identifers: GC01P046501 GC01P045816 GC01P046246 GC01P046229 GC01P046572 GC01P046632 GC01P044975


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAAH Gene:
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid
amides, including the neuromodulatory compounds anandamide and oleamide. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAAH Gene: 
FAAH (fatty acid amide hydrolase) is a protein-coding gene. Diseases associated with FAAH include cannabis dependence, and fatty acid hydroxylase-associated neurodegeneration, and among its related super-pathways are GABAergic synapse and D-myo-inositol-5-phosphate metabolism. GO annotations related to this gene include fatty acid amide hydrolase activity and acylglycerol lipase activity. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic
amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates

summary for FAAH Gene:
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane
protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH
distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the
pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small
intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second
FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAAH gene promoter:
         Pax-5   MEF-2   HTF   Lmo2   Evi-1   MEF-2A   STAT3   aMEF-2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAAH promoter sequence
   Search SABiosciences Chromatin IP Primers for FAAH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p35-p34

FAAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAAH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046860:  view genomic region     (about GC identifiers)

Start:
46,859,937 bp from pter      End:
46,879,520 bp from pter
Size:
19,584 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519 (See protein sequence)
Recommended Name: Fatty-acid amide hydrolase 1  
Size: 579 amino acids; 63066 Da
Subunit: Homodimer (By similarity)
Subcellular location: Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be
attached to intracellular membranes and a portion of the cytoskeletal network
Secondary accessions: D3DQ19 Q52M86 Q5TDF8

Explore the universe of human proteins at neXtProt for FAAH: NX_O00519

Explore proteomics data for FAAH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00519

  • 3 DME Specific Peptides for FAAH (O00519)
     DIGGSIR  GGSIRFP  ALPGASG 

    FAAH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAAH Protein Expression
    REFSEQ proteins: NP_001432.2  
    ENSEMBL proteins: 
     ENSP00000243167  

    Human Recombinant Protein Products for FAAH: 
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    Novus Biologicals FAAH Protein
    Novus Biologicals FAAH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAAH 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--
    GO:0031090organelle membrane ISS--

    FAAH for ontologies           About GeneDecksing



    FAAH Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for FAAH 

    Assay Products for FAAH: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for FAAH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Fatty acid amide hydrolase-1 
    Endocannabinoid turnover

    4 InterPro protein domains:
     IPR020556 Amidase_CS
     IPR000120 Amidase
     IPR023631 Amidase_dom
     IPR015830 Amidase_fun

    Graphical View of Domain Structure for InterPro Entry O00519

    ProtoNet protein and cluster: O00519

    1 Blocks protein domain: IPB000120 Amidase

    UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
    Similarity: Belongs to the amidase family


    FAAH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAAH1_HUMAN, O00519
    Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic
    amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules.
    Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates
    Catalytic activity: Anandamide + H(2)O = arachidonic acid + ethanolamine
    Catalytic activity: Oleamide + H(2)O = oleic acid + NH(3)
    Enzyme regulation: Inhibited by O-aryl carbamates and alpha-keto heterocytes

         Genatlas biochemistry entry for FAAH:
    fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty
    acids such as oleamide and anandamide

         Enzyme Numbers (IUBMB): EC 3.5.1.991 EC 3.5.12 EC 3.5.1.n22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
    GO:0016884carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEA--
    GO:0017064fatty acid amide hydrolase activity IDA9122178
    GO:0047372acylglycerol lipase activity IEA--
         
    FAAH for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FAAH:
     Decreased cilium length  Decreased cilium length after   Synthetic lethal with c-Myc af 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Faah):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  muscle 
     nervous system  normal 

    FAAH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FAAH: Faahtm1Lex Faahtm1Crv

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAAH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAAH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAAH 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAAH
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FAAH:
    hsa-miR-198 hsa-miR-943
    SwitchGear 3'UTR luciferase reporter plasmidFAAH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: FAAH (NM_001441)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of FAAH 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FAAH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    2Anandamide biosynthesis and metabolism
    Anandamide biosynthesis and metabolism0.34
    3anandamide degradation
    anandamide degradation
    4Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FAAH
        Anandamide biosynthesis and metabolism


    1 Cell Signaling Technology (CST) Pathway for FAAH
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for FAAH
        Anandamide biosynthesis and metabolism

    1 BioSystems Pathway for FAAH
        anandamide degradation


    1         Kegg Pathway  (Kegg details for FAAH):
        Retrograde endocannabinoid signaling


    FAAH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FAAH

    5/16 Interacting proteins for FAAH (O005193) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084733I2D: score=2 
    ACACBO007633I2D: score=1 
    CTU1Q7Z7A33I2D: score=1 
    CYC1P085743I2D: score=1 
    GDAQ9Y2T33I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009062fatty acid catabolic process IDA9122178

    FAAH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FAAH for compounds           About GeneDecksing

    EMD Millipore small molecules for FAAH:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for FAAH

    Compounds for FAAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SA 57Potent FAAH inhibitor[1346169-63-8]
    PF 3845Selective FAAH inhibitor[1196109-52-0]
    JNJ 1661010 Selective, reversible FAAH inhibitor [681136-29-8]
    TC-F 2 Potent, reversible and selective FAAH inhibitor [1304778-15-1]

    1 HMDB Compound for FAAH    About this table
    CompoundSynonyms CAS #PubMed Ids
    AnandamideAnandamide (20.4, n-6) (see all 13)94421-68-8--

    6 DrugBank Compounds for FAAH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Methoxy arachidonyl fluorophosphonate-- --target--17139284 17016423 10592235
    Propofol2,6-Diisopropylphenol (see all 2)2078-54-8enzymesubstrate19933260 10592235
    ThiopentalPenthiobarbital (see all 10)76-75-5targetinhibitor11752352 12839875
    1-DODECANOL-- --target--10592235
    4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid-- --target--10592235
    4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid-- --target--10592235

    5 IUPHAR Ligands for FAAH (Fatty acid amide hydrolase-1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    PF750
    InhibitorInhibition6.3 - 7.817949010
    JNJ1661010
    InhibitorInhibition7.818693015
    OL135
    InhibitorInhibition7.417015445
    URB597
    InhibitorInhibition6.3 - 717015445
    PF3845
    InhibitorInhibition6.619389627

    10/39 Novoseek inferred chemical compound relationships for FAAH gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anandamide 96.8 337 11353795 (8), 11118429 (6), 17676056 (5), 10431820 (4) (see all 99)
    2-arachidonoylglycerol 94.2 88 11095952 (4), 18566995 (3), 18394720 (3), 15923084 (2) (see all 30)
    oleamide 93.7 48 10805767 (2), 17177441 (2), 11585048 (2), 17279740 (1) (see all 24)
    urb 597 92.8 37 18814866 (3), 17314320 (2), 16834756 (2), 17511970 (2) (see all 20)
    monoacylglycerol 89.6 52 17649977 (2), 18289091 (2), 17621164 (2), 16854070 (1) (see all 33)
    palmitoylethanolamide 89.5 23 11485574 (4), 11585048 (2), 10431820 (1), 10692582 (1) (see all 9)
    glyceryl arachidonate 81.7 1 16181610 (1)
    linoleoyl ethanolamide 79.8 1 9822713 (1)
    mafp 77.3 11 11118429 (3), 15910884 (1), 11353795 (1), 14718261 (1) (see all 5)
    rimonabant 73.9 3 19559363 (1), 19374636 (1), 16129456 (1)

    1 PharmGKB related drug/compound annotation for FAAH gene    About this table
    Drug/compound PharmGKB Annotation
    methamphetamineCA  

    Search CenterWatch for drugs/clinical trials and news about FAAH / FAAH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAAH gene: 
    NM_001441.2  

    Unigene Cluster for FAAH:

    Fatty acid amide hydrolase
    Hs.720143  [show with all ESTs]
    Unigene Representative Sequence: NM_001441
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243167(uc001cpu.2 uc001cpv.2) ENST00000468718 ENST00000493735
    ENST00000484697 ENST00000489366 ENST00000493636

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FAAH:
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    SwitchGear 3'UTR luciferase reporter plasmidFAAH 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAAH

    Additional mRNA sequence: 

    AL050372.1 BC034478.1 BC093632.1 BC110404.1 BC111941.1 U82535.1 

    11 DOTS entries:

    DT.313625  DT.91741626  DT.121326323  DT.87016642  DT.121326472  DT.95332161  DT.95332175  DT.121326446 
    DT.91685857  DT.121326505  DT.121326373 

    24/336 AceView cDNA sequences (see all 336):

    AI565253 BU785964 AL042018 BM470538 CR620787 CR625030 BF436906 AI468284 
    AK021577 BQ014732 CB049339 BQ424895 CR611548 BU171186 AA301695 AA887288 
    BM682652 CB266514 CA502993 BX346286 AV704481 AI686717 AI167794 AI858750 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FAAH    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                            -                             -                                             
    SP2:                                            -     -     -                 -                 -           -               
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for FAAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATGACAT
    FAAH Expression
    About this image


    See FAAH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAAH

    SOURCE GeneReport for Unigene cluster: Hs.720143

    UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
    Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also
    expressed in the kidney, liver, lung, placenta and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including FAAH: 
              Drug Metabolism in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAAH gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Faah1 , 5 fatty acid amide hydrolase1, 5 84.05(n)1
    83.94(a)1
      4 (53.08 cM)5
    140731  NM_010173.41  NP_034303.31 
     1159671455 
    chicken
    (Gallus gallus)
    Aves FAAH1 fatty acid amide hydrolase 63.32(n)
    57.27(a)
      424614  XM_422450.3  XP_422450.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAAH6
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    55(a)
    50(a)
    (see all 4)
    1 ↔ 1
    possible ortholog
    (see all 4)
    4(112195875-112227243)
    4(112228896-112249310)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.113062 Xenopus laevis transcribed sequence with weak similarity more 71.61(n)    BX851598.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FAAH6
    fatty acid amide hydrolase
    50(a)
    1 ↔ 1
    6(3324243-3352911)
    worm
    (Caenorhabditis elegans)
    Secernentea C25A1.53 Yeast hypothetical 44.9 KD protein like 45(a)
    (best of 7)
      I(10185243-10186628)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AMD2(YDR242W)4 Putative amidase   --   4(946807-948456) 851829  NP_010528.1 


    ENSEMBL Gene Tree for FAAH (if available)
    TreeFam Gene Tree for FAAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAAH gene
    FAAH22  
    1 SIMAP similar gene for FAAH using alignment to 1 protein entry:     FAAH1_HUMAN:
    DKFZp434A091

    FAAH for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAAH
    PGOHUM00000244703


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FAAH1_HUMAN, O00519
    Polymorphism: Variant Thr-129 seems to be strongly associated with illegal drug use and dependence. This variant
    displays normal catalytic properties but an enhanced sensitivity to proteolytic degradation


    10/671 SNPs in FAAH are shown (see all 671)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357044
    A breast cancer sample4--see VAR_0357042 A D mis40--------
    rs3244201,2,4
    C,F,O,A,Hother146948415(+) AGGCCC/ACAAGG 2 /T /P mis1 ese341Minor allele frequency- A:0.26EA NA MN NS WA CSA EU 9775
    rs19844911,2
    C,F,A--46858607(-) CAGGGA/CAGCAA 1 -- us2k16Minor allele frequency- C:0.20NS WA NA 424
    rs454498931,2
    C,F--46859024(+) TTTTCA/GCATTG 1 -- us2k17Minor allele frequency- G:0.20NS WA NA CSA 418
    rs455139921,2
    C,F--46859113(+) ACCTCC/TTCAGG 1 -- us2k12Minor allele frequency- T:0.03NS WA 292
    rs455178371,2
    C,F--46859225(+) CTCGAA/GTATAA 1 -- us2k16Minor allele frequency- G:0.20NS WA NA 420
    rs455795391,2
    C,F--46859282(+) GGGTGC/TGCCCT 1 -- us2k12Minor allele frequency- T:0.01NS NA 296
    rs112885111,2
    C--46862281(+) TTTTT-/GCCAAG 1 -- int10--------
    rs665069311,2
    C--46866715(+) AGGGA-/AAACCA 1 -- int10--------
    rs455162981,2
    C,F--46868833(+) AGTCTT/CGCTCT 1 -- int11Minor allele frequency- C:0.01NS 176

    HapMap Linkage Disequilibrium report for FAAH (46859937 - 46879520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAAH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829748CNV Loss17160897


    Human Gene Mutation Database (HGMD): FAAH
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAAH
    DNA2.0 Custom Variant and Variant Library Synthesis for FAAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602935    OMIM disorders: --

    20/39 diseases for FAAH (see all 39):    About MalaCards
    cannabis dependence    fatty acid hydroxylase-associated neurodegeneration    somatoform disorder    back pain
    bulimia nervosa    obesity, association with    constipation    ectopic pregnancy
    eating disorder    huntington's disease    obesity    anorexia nervosa
    multiple sclerosis    hyperglycemia    pheochromocytoma    schizophrenia
    encephalitis    alcoholism    bipolar disorder    down syndrome

    2 diseases from the University of Copenhagen DISEASES database for FAAH:
    Pain agnosia     Cannabis dependence

    FAAH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/23 Novoseek inferred disease relationships for FAAH gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    miscarriage recurrent 36.8 10 18805581 (6), 12744923 (1), 14580383 (1)
    obesity 33.7 46 20044928 (7), 18819056 (3), 20065978 (2), 19958092 (2) (see all 11)
    catalepsy 31.6 1 16834756 (1)
    miscarriage 31.4 7 19419760 (3), 11390466 (1), 15464041 (1), 18805581 (1) (see all 5)
    inflammation 21.5 17 19184452 (2), 17434980 (1), 14561206 (1), 17949010 (1) (see all 10)
    multiple sclerosis 20.9 3 17329437 (1), 16596785 (1)
    motor disorder 19.7 1 12505686 (1)
    hyperalgesia 16.4 1 17279090 (1)
    anxiety depression 15.2 4 17217969 (1), 19850474 (1), 20462810 (1)
    glioma 15.1 2 11118429 (1), 17325653 (1)

    Genetic Association Database (GAD): FAAH
    Human Genome Epidemiology (HuGE) Navigator: FAAH (50 documents)

    Export disorders for FAAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAAH gene, integrated from 9 sources (see all 336):
    (articles sorted by number of sources associating them with FAAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human and mouse fatty acid amide hydrolases. (PubMed id 9122178)1, 2, 3, 9 Giang D.K. and Cravatt B.F. (1997)
    2. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. (PubMed id 12060782)1, 2, 4 Sipe J.C.... Cravatt B.F. (2002)
    3. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PubMed id 20044928)1, 4, 9 MA1ller T.D....Hinney A. (2010)
    4. Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. (PubMed id 9878243)1, 2, 9 Wan M.... Francke U. (1998)
    5. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. (PubMed id 19165169)1, 4, 9 Lieb W....Fox C.S. (2009)
    6. Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation. (PubMed id 17962356)1, 4, 9 Camilleri M....Zinsmeister A.R. (2008)
    7. Association of polymorphisms of the cannabinoid recep tor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: i mpact of long repeats of CNR1. (PubMed id 20010914)1, 4, 9 Proudnikov D....Kreek M.J. (2010)
    8. [C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and adipocytokine levels in the morbid ly obese] (PubMed id 20189896)1, 4, 9 De Luis D.A....Romero E. (2010)
    9. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. (PubMed id 15721218)1, 4, 9 Morita Y....Kuroda S. (2005)
    10. C358A missense polymorphism of the endocannabinoid-de grading enzyme fatty acid amide hydrolase (FAAH) and visfatin levels in obese f emales. (PubMed id 20065978)1, 4, 9 de Luis D.A....Romero E. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2166 HGNC: 3553 AceView: FAAHandNSUN4 Ensembl:ENSG00000117480 euGenes: HUgn2166
    ECgene: FAAH Kegg: 2166 H-InvDB: FAAH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAAH Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/faah/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAAH gene:
    Search GeneIP for patents involving FAAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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