Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAAH Gene

Aliases for FAAH Gene

  • Fatty Acid Amide Hydrolase 2 3 5
  • Anandamide Amidohydrolase 1 3 4
  • Oleamide Hydrolase 1 3 4
  • Fatty-Acid Amide Hydrolase 1 3
  • EC 3.5.1.n2 61
  • EC 3.5.1.99 4
  • EC 3.5.1 61
  • FAAH-1 3
  • FAAH1 4
  • PSAB 3

External Ids for FAAH Gene

Previous GeneCards Identifiers for FAAH Gene

  • GC01P046501
  • GC01P045816
  • GC01P046246
  • GC01P046229
  • GC01P046572
  • GC01P046632
  • GC01P046860
  • GC01P044975

Summaries for FAAH Gene

Entrez Gene Summary for FAAH Gene

  • This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAAH Gene

FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include Drug Addiction and Autoimmune Encephalitis. Among its related pathways are Ibuprofen Pathway, Pharmacodynamics and Arachidonic acid metabolism. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot for FAAH Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Tocris Summary for FAAH Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH Gene

Genomics for FAAH Gene

Regulatory Elements for FAAH Gene

Enhancers for FAAH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G046338 1.4 ENCODE dbSUPER 7.4 -52.7 -52717 5.5 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 NSUN4 LRRC41 UQCRH EFCAB14-AS1 CYP4B1 FAAH LURAP1 PIR34500
GH01G045749 1.4 Ensembl ENCODE 6.2 -643.0 -643011 3.1 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D CCDC163 MAST2 TOE1 GPBP1L1 RPS8 IPP FAAH LOC105378693 RPL6P1
GH01G046299 1.4 ENCODE dbSUPER 5.9 -91.5 -91487 5.6 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 TBX21 MEF2D ZNF610 GLIS1 LURAP1 TOE1 GPBP1L1 ZSWIM5 FAAH CCDC163 LRRC41 GC01M046227
GH01G046401 1.3 Ensembl ENCODE 6.1 +7.8 7769 1.3 HDGF ARNT ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 ZBTB7B GLIS2 EFCAB14 FAAH FAAHP1
GH01G046519 1.6 FANTOM5 Ensembl ENCODE 4.6 +127.3 127343 3.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS EFCAB14-AS1 DMBX1 IPP KNCN EFCAB14 TEX38 ATPAF1 NSUN4 MKNK1 CYP4Z1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAAH on UCSC Golden Path with GeneCards custom track

Promoters for FAAH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005956 235 1001 ZFP64 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ELK1 KLF7 SP3

Genomic Location for FAAH Gene

Chromosome:
1
Start:
46,394,265 bp from pter
End:
46,413,848 bp from pter
Size:
19,584 bases
Orientation:
Plus strand

Genomic View for FAAH Gene

Genes around FAAH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH Gene

Proteins for FAAH Gene

  • Protein details for FAAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00519-FAAH1_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 1
    Protein Accession:
    O00519
    Secondary Accessions:
    • D3DQ19
    • Q52M86
    • Q5TDF8

    Protein attributes for FAAH Gene

    Size:
    579 amino acids
    Molecular mass:
    63066 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH Gene

Selected DME Specific Peptides for FAAH Gene

O00519:
  • DIGGSIR
  • GGSIRFP
  • ALPGASG

Post-translational modifications for FAAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FAAH Gene

Gene Families for FAAH Gene

Protein Domains for FAAH Gene

Suggested Antigen Peptide Sequences for FAAH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00519

UniProtKB/Swiss-Prot:

FAAH1_HUMAN :
  • Belongs to the amidase family.
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH: view

Function for FAAH Gene

Molecular function for FAAH Gene

GENATLAS Biochemistry:
fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acids such as oleamide and anandamide
UniProtKB/Swiss-Prot CatalyticActivity:
Anandamide + H(2)O = arachidonic acid + ethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleamide + H(2)O = oleic acid + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH Gene

Gene Ontology (GO) - Molecular Function for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004040 amidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0017064 fatty acid amide hydrolase activity IEA,TAS --
GO:0047372 acylglycerol lipase activity IEA --
genes like me logo Genes that share ontologies with FAAH: view
genes like me logo Genes that share phenotypes with FAAH: view

Animal Models for FAAH Gene

MGI Knock Outs for FAAH:

Animal Model Products

  • Taconic Biosciences Mouse Models for FAAH

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAAH Gene

Localization for FAAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH Gene

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAAH gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytoskeleton 3
plasma membrane 2
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005856 cytoskeleton IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAAH: view

Pathways & Interactions for FAAH Gene

genes like me logo Genes that share pathways with FAAH: view

Pathways by source for FAAH Gene

1 Cell Signaling Technology pathway for FAAH Gene
1 BioSystems pathway for FAAH Gene
1 PharmGKB pathway for FAAH Gene
1 KEGG pathway for FAAH Gene
1 GeneGo (Thomson Reuters) pathway for FAAH Gene

Gene Ontology (GO) - Biological Process for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process IDA 9122178
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with FAAH: view

No data available for SIGNOR curated interactions for FAAH Gene

Drugs & Compounds for FAAH Gene

(62) Drugs for FAAH Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiopental Approved, Vet_approved Pharma Target, inhibitor 38
Acetaminophen Approved Pharma Target, inhibitor Cyclooxygenase inhibitor; may be selective for COX-3 1026
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Propofol Approved, Investigational, Vet_approved Pharma Enzyme, substrate 1082
Aripiprazole Approved, Investigational Pharma Antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 358

(18) Additional Compounds for FAAH Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
URB 597
546141-08-6
4-Hydroxypropofol
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
PDP-EA
861891-72-7

(5) Tocris Compounds for FAAH Gene

Compound Action Cas Number
JNJ 1661010 Selective, reversible FAAH inhibitor 681136-29-8
PDP-EA FAAH activator 861891-72-7
PF 3845 Selective FAAH inhibitor 1196109-52-0
TC-F 2 Potent, reversible and selective FAAH inhibitor 1304778-15-1
URB 597 Potent and selective FAAH inhibitor 546141-08-6

(14) ApexBio Compounds for FAAH Gene

Compound Action Cas Number
AACOCF3 Inhibitor of cPLA2/anandamide hydrolysis/FAAH 149301-79-1
AM 1172 Inhibitor of anandamide uptake and FAAH,potent and selective 251908-92-6
FAAH inhibitor 1 326866-17-5
JNJ-1661010 FAAH inhibitor,potent and selective 681136-29-8
JZL 195 1210004-12-8
LY2183240 Blocker of anandamide uptake,highly potent 874902-19-9
PF 750 959151-50-9
PF-04457845 FAAH inhibitor,potent and exquisitely selective 1020315-31-4
PF-3845 FAAH ihibitor,highly potent and selective 1196109-52-0
SA 47 792236-07-8
SA 57 1346169-63-8
TAK 21d 1143578-94-2
TC-F 2 1304778-15-1
URB597 FAAH inhibitor,potent and selective 546141-08-6
genes like me logo Genes that share compounds with FAAH: view

Drug Products

Transcripts for FAAH Gene

Unigene Clusters for FAAH Gene

Fatty acid amide hydrolase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for FAAH Gene

GeneLoc Exon Structure for
FAAH
ECgene alternative splicing isoforms for
FAAH

Expression for FAAH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAAH Gene

Protein differential expression in normal tissues from HIPED for FAAH Gene

This gene is overexpressed in Testis (18.9), Islet of Langerhans (7.9), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAAH Gene



Protein tissue co-expression partners for FAAH Gene

NURSA nuclear receptor signaling pathways regulating expression of FAAH Gene:

FAAH

SOURCE GeneReport for Unigene cluster for FAAH Gene:

Hs.720143

mRNA Expression by UniProt/SwissProt for FAAH Gene:

O00519-FAAH1_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.

Evidence on tissue expression from TISSUES for FAAH Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with FAAH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAAH Gene

Orthologs for FAAH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAAH 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia FAAH 34 35
  • 89.41 (n)
cow
(Bos Taurus)
Mammalia FAAH 34 35
  • 87.51 (n)
rat
(Rattus norvegicus)
Mammalia Faah 34
  • 84.23 (n)
mouse
(Mus musculus)
Mammalia Faah 34 16 35
  • 84.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAAH 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAAH 34 35
  • 63.48 (n)
lizard
(Anolis carolinensis)
Reptilia FAAH 35
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11306 34
zebrafish
(Danio rerio)
Actinopterygii FAAH 35
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30502 36
  • 39 (a)
CG5191 35
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea faah-1 34 35
  • 45.58 (n)
C25A1.5 36
  • 45 (a)
B0218.2 36
  • 35 (a)
F58H7.2 36
  • 35 (a)
faah-2 35
  • 34 (a)
OneToMany
faah-3 35
  • 32 (a)
OneToMany
Y56A3A.12a 36
  • 31 (a)
Y56A3A.12b 36
  • 31 (a)
Y56A3A.5 36
  • 30 (a)
Y41C4A.2 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 35 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08356 34
  • 45.26 (n)
Species where no ortholog for FAAH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAAH Gene

ENSEMBL:
Gene Tree for FAAH (if available)
TreeFam:
Gene Tree for FAAH (if available)

Paralogs for FAAH Gene

Paralogs for FAAH Gene

(1) SIMAP similar genes for FAAH Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAAH Gene

genes like me logo Genes that share paralogs with FAAH: view

Variants for FAAH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH Gene

FAAH1_HUMAN-O00519
Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and methamphetamine dependence.

Sequence variations from dbSNP and Humsavar for FAAH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs772931153 A breast cancer sample 46,408,541(+) GCGGG(A/C)CGTGC reference, missense
rs324420 other 46,405,089(+) AGGCC(A/C)CAAGG reference, missense
rs1000118692 -- 46,400,304(+) GATGG(A/G)GATTT intron-variant
rs1000247574 -- 46,407,204(+) AGGCA(A/G)CACTG intron-variant
rs1000401890 -- 46,412,971(+) TTCTC(C/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH Gene

Variant ID Type Subtype PubMed ID
esv2761743 CNV gain 21179565
nsv546162 CNV loss 21841781
nsv829748 CNV loss 17160897

Variation tolerance for FAAH Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAAH Gene

Human Gene Mutation Database (HGMD)
FAAH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAAH

Disorders for FAAH Gene

MalaCards: The human disease database

(7) MalaCards diseases for FAAH Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
drug addiction
  • drug dependence
autoimmune encephalitis
  • hashimoto's encephalitis
cannabis dependence
  • marijuana abuse
hallucinogen dependence
somatoform disorder
  • physiological malfunction arising from mental factor
- elite association - COSMIC cancer census association via MalaCards
Search FAAH in MalaCards View complete list of genes associated with diseases

Relevant External Links for FAAH

Genetic Association Database (GAD)
FAAH
Human Genome Epidemiology (HuGE) Navigator
FAAH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAAH
genes like me logo Genes that share disorders with FAAH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH Gene

Publications for FAAH Gene

  1. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. (PMID: 16972078) Flanagan J.M. … Sipe J.C. (Hum. Genet. 2006) 3 4 22 46 64
  2. Molecular characterization of human and mouse fatty acid amide hydrolases. (PMID: 9122178) Giang D.K. … Cravatt B.F. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  3. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PMID: 20010914) Proudnikov D. … Kreek M.J. (Pharmacogenomics J. 2010) 3 22 46 64
  4. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PMID: 20044928) MA1ller T.D. … Hinney A. (BMC Med. Genet. 2010) 3 22 46 64
  5. C358A missense polymorphism of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) and visfatin levels in obese females. (PMID: 20065978) de Luis D.A. … Romero E. (Int J Obes (Lond) 2010) 3 22 46 64

Products for FAAH Gene

Sources for FAAH Gene

Content
Loading form....