Aliases for FAAH Gene
External Ids for FAAH Gene
Previous GeneCards Identifiers for FAAH Gene
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
GeneCards Summary for FAAH Gene
FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include drug addiction and spastic paraplegia 35, autosomal recessive. Among its related pathways are Glucose / Energy Metabolism and Circadian entrainment. GO annotations related to this gene include acylglycerol lipase activity and fatty acid amide hydrolase activity. An important paralog of this gene is FAAH2.
UniProtKB/Swiss-Prot for FAAH Gene
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH distribution is noticeably different between human and rat. In humans, FAAH is mainly present in the pancreas, brain, kidney, skeletal muscle, and placenta. In rat, FAAH is mainly detected in the liver, small intestine, brain, kidney, spleen, testis, and uterus, but is absent from skeletal muscle and heart. A second FAAH (FAAH2) was identified recently in humans but is absent from rats and mice.