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F9 Gene

protein-coding GIFtS: 66

GC0XP138440

coagulation factor IX
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.21.22 ^³
FIX ^¹, ²
HEMB ^², ⁵
MGC129641 ^²
MGC129642 ^²
OTTHUMP00000024154 ^²
PTC ^², ³

Descriptions
Christmas factor ^², ³
Plasma thromboplastin component ^³
coagulation factor IX ^²
factor 9 ^²
plasma thromboplastic component ^²

External Ids
HGNC: 3551¹
Entrez Gene: 2158²
UniProtKB: P00740³
Ensembl: ENSG00000101981⁷

Search outside databases for aliases for F9 gene

Previous GC identifers: GC0XP133196 GC0XP135470 GC0XP136557 GC0XP137318 GC0XP138338

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F9:

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an

inactive zymogen. This factor is converted to an active form by factor XIa, which excises the

activation peptide and thus generates a heavy chain and a light chain held together by one or more

disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to

activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids,

and factor VIII. Alterations of this gene, including point mutations, insertions and deletions,

cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or

Christmas disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: FA9_HUMAN, P00740

Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic

pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+)

ions, phospholipids, and factor VIIIa

Gene Wiki entry for F9 (Factor_IX)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F9 gene

Entrez Gene cytogenetic band: Xq27.1-q27.2 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq26.3-q27.1

F9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP138440: (about GC identifiers)

Start:	138,440,561 bp from pter
End:	138,473,283 bp from pter
Size:	32,723 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FA9_HUMAN, P00740 (See protein sequence)

Recommended Name: Coagulation factor IX precursor

Size: 461 amino acids; 51778 Da

Subunit: Heterodimer of a light chain and a heavy chain; disulfide-linked

Subcellular location: Secreted

Miscellaneous: In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used

the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor

which he called the 'Christmas Factor' At the time Stephen Christmas was a 5-year-old boy. He died

in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with

blood products

PDB structures from and Proteopedia :

1CFH (3D)

1CFI (3D)

1EDM (3D)

1IXA (3D)

1MGX (3D)

1NL0 (3D)

1RFN (3D)

Secondary accessions: Q5JYJ8

Post-translational modifications:

Activated by factor XIa, which excises the activation peptide¹

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R)

stereospecific within EGF domains¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000124.1

ENSEMBL proteins:

ENSP00000377650 ENSP00000218099

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (F9, Factor IXa, Factor IX)
	Human Recombinant Proteins from Abnova (F9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	EXP	2110473 8626656

About this table

Antibodies for F9:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of F9
	Sigma-Aldrich Antibodies for F9
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (F9, Factor IXa, Factor IX), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F9)
	Novus Biologicals Antibodies for F9

Assays for F9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00740

ProtoNet protein and cluster: P00740

5/7 Blocks protein families (see all 7 ):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB001438 Type II EGF-like signature

UniProtKB/Swiss-Prot: FA9_HUMAN, P00740

Domain: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity,

to another site, beyond the Gla domain

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000133

Applied Biosystems Silencer® siRNAs for F9

Sigma-Aldrich siRNA and siRNA Panels for F9

Sigma-Aldrich shRNA Panels and shRNA for F9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000133
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000133
untagged cDNA clone in CMV expression vector: NM_000133

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000133

UniProtKB/Swiss-Prot: FA9_HUMAN, P00740

Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic

pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+)

ions, phospholipids, and factor VIIIa

Catalytic activity: Selective cleavage of Arg- -Ile bond in factor X to form factor Xa

Enzyme Number (IUBMB): EC 3.4.21.22

Genatlas biochemistry entry for F9:

coagulation factor IX,vitamin K-dependent (plasma thromboplastic component)

7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for F9):

	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
life span-post-weaning/aging	liver/biliary system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	TAS	2472424
GO:0005509	calcium ion binding	IEA	--
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for F9 (Your Favorite Gene powered by Ingenuity)

Lysine Degradation
Coagulation System

GeneDecks F9 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for F9

5/33 Interacting proteins for F9 (ENSP00000218099³) via UniProtKB, MINT, and/or STRING (see all 33 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F8	ENSP00000327895³	STRING (score=.999)
GGCX	ENSP00000233838³	STRING (score=.998)
F3	ENSP00000334145³	STRING (score=.993)
SERPINC1	ENSP00000356671³	STRING (score=.993)
VWF	ENSP00000261405³	STRING (score=.98)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007598	blood coagulation, extrinsic pathway	EXP	7598447

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for F9
UniProtKB/Swiss-Prot: FA9_HUMAN, P00740

Pharmaceutical: Available under the names BeneFix (Baxter and American Home Products). Used to

treat hemophilia B

10/51 Novoseek chemical compound relationships for F9 gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gamma-carboxyglutamic acid	87.74	113	12496253 (6), 8180219 (4), 17387172 (3), 9169594 (3) (see all 32)
erythro-beta-hydroxyaspartic acid	78.23	1	7906269 (1)
p-amino benzamidine	76.34	8	15829482 (1), 17676929 (1), 7740454 (1)
fibrinogen	68.42	59	18409149 (4), 11111234 (2), 12228267 (2), 17586991 (2) (see all 49)
echicetin	54.00	1	7599152 (1)
phospholipid	52.28	39	2248955 (3), 7680311 (3), 2363125 (2), 7547952 (2) (see all 23)
dithio	50.52	5	2355000 (2), 1438159 (1), 2249997 (1)
chymotrypsinogen	50.52	1	11551226 (1)
tributylphosphate	35.37	3	10799053 (1)
tetrasaccharide	34.50	6	1517205 (2), 7896789 (1), 7681016 (1), 10734111 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000133

Sigma-Aldrich siRNA and siRNA Panels for F9

Sigma-Aldrich shRNA Panels and shRNA for F9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000133

REFSEQ mRNAs for F9 gene:

NM_000133.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000133

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000133
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000133
                                 untagged cDNA clone in CMV expression vector: NM_000133

Additional cDNA sequence:

AB186358.1 AK292749.1 BC109214.1 BC109215.1 J00136.1 J00137.1 M11309.1 M35672.1

4 DOTS entries:

DT.100735617 DT.208175 DT.91668233 DT.91668240

24 AceView cDNA sequences:

NM_000133 T28608 M35672 M11309 A22478 CD607649 CB157484 BX495480

J00136 CB156936 J00137 A22493 BX495491 AV694632 AV689501 AV696892

AV695793 AV698079 AV684051 AV695911 AV687276 AV685937 BX448845 AV690464

highest scoring ESTs for F9:

CB156936 CB157484 J00136 J00137 M11309 M35672 T28608 AB186358 AV647038 AV647182

Unigene Cluster for F9:

Coagulation factor IX

Hs.522798 [show with all ESTs]

Unigene Representative Sequence: NM_000133

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000394090 ENST00000218099

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F9

¹ / ² / ³

3 probe-sets matching F9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35556_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	K02402	0.20	1.00	0.72	1
207218_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000133	0.60	1.00	0.82	1
207218_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F9 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAACATTTTG

SOURCE GeneReport for Unigene cluster: Hs.522798
Expression variation in blood from EXPOLDB for F9
UniProtKB/Swiss-Prot: FA9_HUMAN, P00740
Tissue specificity: Synthesized primarily in the liver and secreted in plasma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F9 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F9¹	--	coagulation factor IX	88.32(n) 86.25(a)	404015 NM_001003323.1 NP_001003323.1
chimpanzee (Pan troglodytes)	F9¹	--	coagulation factor IX	99.77(n) 99.77(a)	465887 XM_521288.2 XP_521288.2
cow (Bos taurus)	F9¹	--	coagulation factor IX	88.4(n) 83.99(a)	280688 XM_581622.3 XP_581622.2
rat (Rattus norvegicus)	F9¹	--	coagulation factor IX	79.71(n) 76.09(a)	24946 XM_346365.3 XP_346366.3
mouse (Mus musculus)	F9^{1, 5}	X (22.00 cM)⁵	coagulation factor IX^{1, 5}	85.9(n)¹ 82(a)¹	14071¹ NM_007979.1¹ NP_032005.1¹ AK149372⁵ AL671984⁵ (see all 12)

About this table Species with no ortholog for F9

ENSEMBL Gene Tree for F9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F9 gene

F10² F7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/208 NCBI SNPs in F9 are shown (see all 208 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 107)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs440051^1,2	A,C,F,H,O	138472583(+)	`CTTCCG/ATAGTG`	1	--	ut3¹ ese³		24	EA NA NS MN EU WA	1858
	rs6048^1,2	C,F,H,O	138460946(+)	`CTGAGA/GCTGTT`	1	T/A	mis¹		14	MN EA NA NS EU WA	1141
	rs411017^1,2	A,C,F,H	138439768(+)	`attcaG/Atcgag`	1	--	ng5¹ tfbs³		12	NS EU EA WA	1170
	rs3788871^1,2	C,F,H	138473295(+)	`GCTTTT/CTGTGG`	1	--	ng3¹		4	EU EA WA	418
--	rs368959^1,2	A,C,F	138439375(+)	`gggggC/Tgaggg`	1	--	ng5¹		2	NS	90
	rs4149657^1,2	C,F,H	138440000(+)	`AAATGT/GGATCC`	1	--	ng5¹		11	NS EU EA WA	563
	rs378815^1,2	C,F,H	138439863(+)	`TTGACC/TTAAAC`	1	--	ng5¹		6	NS EU EA WA	498
	rs4149763^1,2	C,H	138472372(+)	`AGAGGC/ATAAAA`	1	--	ut3¹ ese³		6	NS EU EA WA	512
--	rs4149751^1,2	F,H	138471891(+)	`AGCTCA/CCTTAA`	1	T/P	mis¹ ese³		6	NS EU EA WA	473
	rs4149752^1,2	F,H	138473475(+)	`GCATAT/CAAGTA`	1	--	ng3¹		6	NS EU EA WA	514

About this table

HapMap Linkage Disequilibrium images for F9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300746 disorders: 306900

UniProtKB/Swiss-Prot: FA9_HUMAN, P00740

Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also

known as Christmas disease

Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the

propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation

in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the

activation peptide

10/93 Novoseek disease relationships for F9 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hemophilia b	98.46	478	7974341 (4), 1495722 (4), 11931806 (3), 8579061 (3) (see all 99)
hemophilia a	88.48	69	15508114 (2), 18388500 (2), 8352232 (2), 2105634 (1) (see all 53)
coagulopathy	83.66	67	9883841 (2), 1495722 (2), 2105634 (1), 1905206 (1) (see all 51)
factor xi deficiency	76.69	7	8639777 (2), 12432326 (1), 15611579 (1), 15842381 (1) (see all 6)
factor vii deficiency	73.30	5	8904177 (1), 10805278 (1), 15660984 (1), 7579395 (1) (see all 5)
bleeding	71.20	125	18721150 (4), 7886549 (3), 16269929 (3), 9446637 (3) (see all 84)
factor x deficiency	66.94	4	8028609 (2), 9038673 (1), 18374200 (1)
von willebrand disease	64.35	15	7600466 (1), 12432326 (1), 15357775 (1), 10517121 (1) (see all 13)
inherited coagulation disorders	63.01	4	11735604 (1), 12109144 (1)
hemarthrosis	62.25	4	8579741 (1), 18716130 (1), 15569163 (1), 1782338 (1)

About this table

Genatlas disease: F9

hemophilia B,Christmas disease,with a higher rate of transmitted mutation with increased maternal

age

GeneTests: F9

Hemophilia B

Human Gene Mutation Database: F9
Genetic Association Database: F9
Human Genome Epidemiology Navigator: F9 (17 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/901 PubMed articles for F9 gene (see all 901 ):

Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX. (PubMed id 1346975)^{1, 3, 4} Ludwig M.... Bajaj S.P. (1992)
Identification of the phospholipid binding site in the vitamin K- dependent blood coagulation protein factor IX. (PubMed id 8663165)^{1, 3, 4} Freedman S.J....Furie B. (1996)
Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX. (PubMed id 7547952)^{1, 3, 4} Freedman S.J.... Baleja J.D. (1995)
Activation peptide of human factor IX has oligosaccharides O- glycosidically linked to threonine residues at 159 and 169. (PubMed id 8172892)^{1, 3, 4} Agarwala K.L.... Iwanaga S. (1994)
Molecular pathology of haemophilia B in Turkish patients: identification of a large deletion and 33 independent point mutations. (PubMed id 12588353)^{1, 3, 4} Onay U.V.... Caglayan S.H. (2003)
Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by two-dimensional NMR spectroscopy. (PubMed id 7713897)^{1, 3, 4} Freedman S.J.... Baleja J.D. (1995)
The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. (PubMed id 7606779)^{1, 3, 4} Rao Z.... Stuart D. (1995)
The Arg-4 mutant factor IX Strasbourg 2 shows a delayed activation by factor XIa. (PubMed id 8295821)^{1, 3, 4} de la Salle C....Balland A. (1993)
Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue. (PubMed id 1517205)^{1, 3, 4} Nishimura H.... Iwanaga S. (1992)
The three-dimensional structure of the first EGF-like module of human factor IX: comparison with EGF and TGF-alpha. (PubMed id 1304885)^{1, 3, 4} Baron M.... Campbell I.D.C. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2158	HGNC: 3551	AceView: F9	Ensembl:ENSG00000101981	euGenes: HUgn2158
ECgene: F9	H-InvDB: F9

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Factor_IX
HAEMB	http://www.kcl.ac.uk/ip/petergreen/haemBdatabase.html
GeneReviews	http://www.genetests.org/query?gene=F9
SeattleSNPs	http://pga.gs.washington.edu/data/f9/
BeneFix	http://www.wyeth.com/products/benefix.asp
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt041.shtml

Licensable Technologies for F9
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F9		Antibodies for F9
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for F9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (F9)
	Antibodies (F9)
	Chimera RNAi (F9)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (F9, Factor IXa, Factor IX)
	Antibodies (F9, Factor IXa, Factor IX)

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Antibodies for F9

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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F9 Gene at Home site.
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F9 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for F9

Summaries
for F9

Genomic Location
for F9

Proteins
for F9

Protein Domains/
Families
for F9

Gene Function
for F9

Pathways & Interactions
for F9

Drugs & Compounds
for F9

Transcripts
for F9

Expression
for F9

Orthologs
for F9

Paralogs
for F9

SNPs/Variants
for F9

Disorders & Mutations
for F9

Medical News
for F9

Publications
for F9

Search for F9

Genome Databases showing F9

Other Databases showing F9

Specialized Databases showing F9

Licensable Technologies
for F9

Services
for F9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F9 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor F9

Summariesfor F9

Genomic Locationfor F9

Proteinsfor F9

Protein Domains/Familiesfor F9

Gene Functionfor F9

Pathways & Interactionsfor F9

Drugs & Compoundsfor F9

Transcriptsfor F9

Expression for F9

Orthologsfor F9

Paralogsfor F9

SNPs/Variantsfor F9

Disorders & Mutationsfor F9

Medical Newsfor F9

Publicationsfor F9

Search for F9

Genome Databases showing F9

Other Databases showing F9

Specialized Databases showing F9

Licensable Technologiesfor F9

Servicesfor F9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F9

Summaries
for F9

Genomic Location
for F9

Proteins
for F9

Protein Domains/
Families
for F9

Gene Function
for F9

Pathways & Interactions
for F9

Drugs & Compounds
for F9

Transcripts
for F9

Expression
for F9

Orthologs
for F9

Paralogs
for F9

SNPs/Variants
for F9

Disorders & Mutations
for F9

Medical News
for F9

Publications
for F9

Licensable Technologies
for F9

Services
for F9