F7 Gene
protein-coding GIFtS: 69
GCID: GC13P113760
|
|
coagulation factor VII (serum prothrombin conversion accelerator)
| |
Aliases
for F7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)1 2 | | FVII Coagulation Protein2 | | Eptacog Alfa2 3 | | Proconvertin3 | | SPCA2 3 | | Proconvertin3 | | EC 3.4.21.213 8 | | Serum Prothrombin Conversion Accelerator3 | | Coagulation Factor VII2 | | EC 3.4.218 |
Export aliases for F7 gene to outside databasesPrevious GC identifers: GC13P112370 GC13P108397 GC13P112846 GC13P111708 GC13P112808 GC13P094198 |
Summaries
for F7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for F7:
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factorcirculates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factorXIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domainand a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond.In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade byconverting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy.Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided byRefSeq, May 2012)
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in azymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minorproteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa bylimited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor andcalcium
Gene Wiki entry for F7 (Factor VII)
|
Genomic Views
for F7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_027140.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the F7 gene promoter:
COUP-TF1 COUP-TF AP-1 COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for F7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34F7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P113760: view genomic region
(about GC identifiers)
Start:
|
113,760,105 bp from pter |
End:
|
113,774,995 bp from pter |
Size:
|
14,891 bases |
Orientation:
|
plus strand |
|
Proteins
for F7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709 (See
protein sequence)Recommended Name: Coagulation factor VII precursor Size: 466 amino acids; 51594 Da
Subunit: Heterodimer of a light chain and a heavy chain linked by a disulfide bond
Subcellular location: Secreted
6/47 PDB 3D structures from  and Proteopedia  for F7 (see all 47):1BF9 (3D)
1CVW (3D)
1DAN (3D)
1DVA (3D)
1F7E (3D)
1F7M (3D)
Secondary accessions: B0YJC8 Q14339 Q5JVF1 Q5JVF2 Q9UD52 Q9UD53 Q9UD54Alternative splicing: 2 isoforms: P08709-1 P08709-2 Explore the universe of human proteins at neXtProt for F7: NX_P08709
Post-translational modifications:
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium1
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGFdomains1
O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containingcomplexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes beforefolding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequenceC2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines1
View neXtProt modification sites for NX_P08709
4/19 DME Specific Peptides for F7 (P08709) (see all 19)
F7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000122.1 NP_001254483.1 NP_062562.1
ENSEMBL proteins: ENSP00000329546 ENSP00000364731 ENSP00000387669 ENSP00000442051 Reactome Protein details: P08709
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
F7 for ontologies About GeneDecksing
F7 Antibody Products:
Assay Products for F7: |
Protein
Domains /
Families
for F7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
F7 for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry P08709ProtoNet protein and cluster: P08709 5/7 Blocks protein families (see all 7): IPB000152 Aspartic acid and asparagine hydroxylation site IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature IPB001438 Type II EGF-like signature
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709Similarity: Belongs to the peptidase S1 familySimilarity: Contains 2 EGF-like domainsSimilarity: Contains 1 Gla (gamma-carboxy-glutamate) domainSimilarity: Contains 1 peptidase S1 domain |
Function
for F7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in azymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minorproteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa bylimited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor andcalciumCatalytic activity: Selective cleavage of Arg- -Ile bond in factor X to form factor Xa Genatlas biochemistry entry for F7:coagulation factor VII,vitamin K-dependent (serum protein conversion accelerator),the active form being generated bythe cleavage of Arg152-Ile153 peptide bond and complexing to cofactor F3 of tissue factor
Enzyme Numbers (IUBMB): EC 3.4.21.211 2 EC 3.4.212
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for F7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): F7 (NM_000131) | |  | Sino Biological Human cDNA Clone for F7 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for F7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F7 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
F7 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for F7:
Animal Models:
Mouse knock-out F7tm1Pec for F7
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for F7):
F7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for F7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | | | 2 | Formation of Fibrin Clot (Clotting Cascade) | | | 3 | Complement and coagulation cascades | | | 4 | Circadian rhythm - mammal | | | 5 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for F7
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F7
3  BioSystems Pathways for F7
5/13 
Reactome Pathways for F7 (see all 13)
1  PharmGKB Pathway for F7
1 
Kegg Pathway (Kegg details for F7):
F7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/21 Interacting proteins for F7 (P087092, 3 ENSP000003647314) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table
F7 for ontologies About GeneDecksing
|
Drugs & Compounds
for F7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
F7 for compounds About GeneDecksing
 Browse Tocris compounds for F7
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709Pharmaceutical: Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleedingepisodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX
2 HMDB Compounds for F7 About this table
10/12 DrugBank Compounds for F7 (see all 12) About this table
10/15 Novoseek chemical compound relationships for F7 gene (see all 15) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fibrinogen |
70.8 |
46 |
8651250 (2), 9636964 (2), 19577483 (2), 2335101 (1) (see all 40) |
| gamma-carboxyglutamic acid |
55.1 |
3 |
1633870 (1), 18373251 (1), 9184404 (1) |
| warfarin |
38.9 |
1 |
2377284 (1) |
| serine |
36.6 |
8 |
1970743 (1), 11876468 (1), 18058827 (1), 8639446 (1) (see all 8) |
| cholesterol |
34.2 |
5 |
8386689 (1), 17059418 (1), 1793443 (1) |
| kininogen |
26.6 |
1 |
10225721 (1) |
| levonorgestrel |
20.1 |
1 |
11810082 (1) |
| glucose |
13.8 |
5 |
9591743 (1), 2055073 (1), 12917499 (1), 17675296 (1) |
| lipid |
4.79 |
5 |
9005605 (1), 8651250 (1), 14766762 (1), 1753430 (1) |
| gentamicin |
2.31 |
1 |
16879227 (1) |
Search CenterWatch for drugs/clinical trials and news about F7 / FA7
|
Transcripts
for F7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for F7 gene (3 alternative transcripts): NM_000131.4 NM_001267554.1 NM_019616.3 Unigene Cluster for F7: Coagulation factor VII (serum prothrombin conversion accelerator) Hs.36989 [show with all ESTs]Unigene Representative Sequence: NM_0001316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000346342(uc010agp.1) ENST00000375581(uc001vsv.3 uc001vsw.3 uc010tjt.2)
ENST00000444337 ENST00000479674 ENST00000473085 ENST00000541084
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for F7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): F7 (NM_000131) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for F7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F7 |
Additional cDNA sequence: AK298404.1 AK310779.1 AK311565.1 AK311682.1 AY423856.1 BC130468.1 EF421855.1 EU557239.1 M13232.1 NR_051961.1 2 DOTS entries: DT.107779 DT.92417225 21 AceView cDNA sequences: AI076552 AL531727 CB156039 AI076550 NM_000131 AA701917 BV199077 NM_019616 BX095482 AA256666 AA256665 AY423856 M78203 M13232 AA677801 AU099140 AL531726 AA133523 AI247880 AA002224 BE939170
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for F7 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for F7
|
Expression
for F7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| F7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See F7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for F7
SOURCE GeneReport for Unigene cluster: Hs.36989
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709Tissue specificity: Plasma
SABiosciences Custom PCR Arrays for F7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for F7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat F7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F7 |
Orthologs
for F7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for F7 gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F71 |
coagulation factor VII (serum prothrombin conversion more |
59.68(n)
57.11(a) |
|
395086 NM_204442.1 NP_989773.1 |
lizard
(Anolis carolinensis) |
Reptilia |
F76 |
-- |
47(a) |
1 ↔ 1 |
3(105930694-105943088) |
zebrafish
(Danio rerio) |
Actinopterygii |
AY040345.12 |
-- |
72.42(n) |
|
114423 AY040345.1 |
ENSEMBL Gene Tree for F7 (if available)
TreeFam Gene Tree for F7 (if available) |
Paralogs
for F7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for F7 gene
- PROZ2 PAMR12 C1S2 C1R2 C1RL2 F92 MASP12 F102
- F22 HPR2 HP2 PROC2 MASP22
18/56 SIMAP similar genes for F7 using alignment to 6 protein entries: FA7_HUMAN (see all proteins)
(see all similar genes):F2 F9 PROC1 DKFZp586F0824 F12 FBN2
GAS6 MATN2 SNED1 HP F9 p22 factor IX F9
F10 PROC TRY8 PRSS1 PRSS45 GZMK
F7 for paralogs About GeneDecksing
|
Genomic Variants
for F7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
|
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|
