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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F7 Gene

protein-coding   GIFtS: 68
GCID: GC13P113760

Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)1 2     Coagulation Factor VII2
Eptacog Alfa1 2 3     proconvertin2
FVII Coagulation Protein1 2     Proconvertin3
SPCA2 3     Serum Prothrombin Conversion Accelerator3
EC 3.4.21.213 8     EC 3.4.218
Factor VII1     

External Ids:    HGNC: 35441   Entrez Gene: 21552   Ensembl: ENSG000000575937   OMIM: 6138785   UniProtKB: P087093   

Export aliases for F7 gene to outside databases

Previous GC identifers: GC13P112370 GC13P108397 GC13P112846 GC13P111708 GC13P112808 GC13P094198


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F7 Gene:
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This
factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor
Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a
catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together
by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates
the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene
can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for F7 Gene: 
F7 (coagulation factor VII (serum prothrombin conversion accelerator)) is a protein-coding gene. Diseases associated with F7 include factor vii deficiency, and factor v deficiency, and among its related super-pathways are Blood Coagulation Signaling Pathways and Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is PAMR1.

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709
Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a
zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor
proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa
by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor
and calcium

Gene Wiki entry for F7 (Factor VII) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F7 gene promoter:
         COUP-TF1   COUP-TF   AP-1   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for F7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

F7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F7 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113760:  view genomic region     (about GC identifiers)

Start:
113,760,105 bp from pter      End:
113,774,995 bp from pter
Size:
14,891 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709 (See protein sequence)
Recommended Name: Coagulation factor VII precursor  
Size: 466 amino acids; 51594 Da
Subunit: Heterodimer of a light chain and a heavy chain linked by a disulfide bond
Subcellular location: Secreted
6/49 PDB 3D structures from and Proteopedia for F7 (see all 49):
1BF9 (3D)        1CVW (3D)        1DAN (3D)        1DVA (3D)        1F7E (3D)        1F7M (3D)    
Secondary accessions: B0YJC8 Q14339 Q5JVF1 Q5JVF2 Q9UD52 Q9UD53 Q9UD54
Alternative splicing: 2 isoforms:  P08709-1   P08709-2   

Explore the universe of human proteins at neXtProt for F7: NX_P08709

Explore proteomics data for F7 at MOPED 

Post-translational modifications:

  • UniProtKB: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind
    calcium
  • UniProtKB: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF
    domains
  • UniProtKB: O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing
    complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before
    folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence
    C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines
  • View neXtProt modification sites for NX_P08709

  • 4/19 DME Specific Peptides for F7 (P08709) (see all 19)
     FEGRNCE  CGGTLIN  NGGSCKD  TGIVSWG 

    F7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    F7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000122.1  NP_001254483.1  NP_062562.1  

    ENSEMBL proteins: 
     ENSP00000329546   ENSP00000364731   ENSP00000387669   ENSP00000442051  
    Reactome Protein details: P08709
    Human Recombinant Protein Products for F7: 
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    Novus Biologicals F7 Proteins
    Novus Biologicals F7 Lysates
    Sino Biological Recombinant Protein for F7
    Sino Biological Cell Lysate for F7 
    ProSpec Recombinant Protein for F7
    Cloud-Clone Corp. Proteins for F7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--
    GO:0005886plasma membrane TAS--

    F7 for ontologies           About GeneDecksing



    F7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/12 InterPro protein domains (see all 12):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR001314 Peptidase_S1A
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry P08709

    ProtoNet protein and cluster: P08709

    5/7 Blocks protein domains (see all 7):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB001438 Type II EGF-like signature


    UniProtKB/Swiss-Prot: FA7_HUMAN, P08709
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 1 peptidase S1 domain


    F7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FA7_HUMAN, P08709
    Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a
    zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor
    proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa
    by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor
    and calcium
    Catalytic activity: Selective cleavage of Arg- -Ile bond in factor X to form factor Xa

         Genatlas biochemistry entry for F7:
    coagulation factor VII,vitamin K-dependent (serum protein conversion accelerator),the active form being generated
    by the cleavage of Arg152-Ile153 peptide bond and complexing to cofactor F3 of tissue factor

         Enzyme Numbers (IUBMB): EC 3.4.21.211 2 EC 3.4.212

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI3455766
    GO:0003824catalytic activity ----
    GO:0004175endopeptidase activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005102receptor binding IEA--
         
    F7 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for F7:
     Decreased Salmonella enterica   Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Metaphase cells 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for F7):
     cardiovascular system  homeostasis/metabolism  mortality/aging  no phenotypic analysis  normal 

    F7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out F7tm1Pec for F7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for F7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for F7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F7 
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): F7 (NM_000131)
    Sino Biological Human cDNA Clone for F7
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for F7 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Clotting Cascade0.42
    Blood Coagulation Signaling Pathways0.51
    2Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.89
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.82
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.89
    Warfarin Pathway, Pharmacodynamics0.67
    Gamma-carboxylation of protein precursors0.89
    Extrinsic Pathway0.30
    3Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    4Circadian Clock
    Circadian Clock0.40
    BMAL1:CLOCK/NPAS2 Activates Circadian Expression0.40
    5Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for F7
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F7
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade

    3 BioSystems Pathways for F7
        Blood Clotting Cascade
    Selenium Pathway
    Complement and Coagulation Cascades


    5/12        Reactome Pathways for F7 (see all 12)
        Hemostasis
    Circadian Clock
    Extrinsic Pathway
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

    1 PharmGKB Pathway for F7
        Warfarin Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for F7):
        Complement and coagulation cascades


    F7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/21 Interacting proteins for F7 (P087092, 3 ENSP000003647314) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48178 I2D: score=2 
    F3P137263, ENSP000003341454I2D: score=5 STRING: ENSP00000334145
    HPNP059813, ENSP000002626264I2D: score=2 STRING: ENSP00000262626
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    GGCXP384353, ENSP000002338384I2D: score=1 STRING: ENSP00000233838
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002690positive regulation of leukocyte chemotaxis IDA17991872
    GO:0006508proteolysis TAS--
    GO:0007596blood coagulation TAS--
    GO:0007598blood coagulation, extrinsic pathway TAS--
    GO:0007623circadian rhythm IEA--

    F7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for F7 (FA7)

    UniProtKB/Swiss-Prot: FA7_HUMAN, P08709
    Pharmaceutical: Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding
    episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX

    2 HMDB Compounds for F7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--

    10/12 DrugBank Compounds for F7 (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation Factor IXChristmas factor (see all 4)9001-28-9targetligand10192655 10617609 659613 10938981 10498586 10381508
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--12525826 16370916 15907148 10388743 11735107
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetactivator17139284 17016423
    2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE-- --target--10592235
    5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)-- --target--10592235
    [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA-- --target--10592235
    {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID-- --target--10592235
    (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID-- --target----
    2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE)-- --target----
    2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE)-- --target----

    10/15 Novoseek inferred chemical compound relationships for F7 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 70.8 46 8651250 (2), 9636964 (2), 19577483 (2), 2335101 (1) (see all 40)
    gamma-carboxyglutamic acid 55.1 3 1633870 (1), 18373251 (1), 9184404 (1)
    warfarin 38.9 1 2377284 (1)
    serine 36.6 8 1970743 (1), 11876468 (1), 18058827 (1), 8639446 (1) (see all 8)
    cholesterol 34.2 5 8386689 (1), 17059418 (1), 1793443 (1)
    kininogen 26.6 1 10225721 (1)
    levonorgestrel 20.1 1 11810082 (1)
    glucose 13.8 5 9591743 (1), 2055073 (1), 12917499 (1), 17675296 (1)
    lipid 4.79 5 9005605 (1), 8651250 (1), 14766762 (1), 1753430 (1)
    gentamicin 2.31 1 16879227 (1)

    Search CenterWatch for drugs/clinical trials and news about F7 / FA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for F7 gene (3 alternative transcripts): 
    NM_000131.4  NM_001267554.1  NM_019616.3  

    Unigene Cluster for F7:

    Coagulation factor VII (serum prothrombin conversion accelerator)
    Hs.36989  [show with all ESTs]
    Unigene Representative Sequence: NM_000131
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346342(uc010agp.1) ENST00000375581(uc001vsv.3 uc001vsw.3 uc010tjt.2)
    ENST00000444337 ENST00000479674 ENST00000473085 ENST00000541084
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F7

    Additional mRNA sequence: 

    AK298404.1 AK310779.1 AK311565.1 AK311682.1 AY423856.1 BC130468.1 EF421855.1 EU557239.1 
    M13232.1 NR_051961.1 

    2 DOTS entries:

    DT.107779  DT.92417225 

    21 AceView cDNA sequences:

    AI076550 AL531727 CB156039 AI076552 NM_019616 NM_000131 BX095482 M13232 
    AA256666 M78203 BV199077 AA256665 AA701917 AY423856 AL531726 AA677801 
    AU099140 AA133523 AI247880 AA002224 BE939170 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for F7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                        -                                 
    SP2:                    -                                   -                                 
    SP3:                    -     -           -                 -                                 
    SP4:                                                        -     -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for F7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    F7 Expression
    About this image


    See F7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F7

    SOURCE GeneReport for Unigene cluster: Hs.36989

    UniProtKB/Swiss-Prot: FA7_HUMAN, P08709
    Tissue specificity: Plasma

        SABiosciences Custom PCR Arrays for F7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for F7
    OriGene qSTAR qPCR primer pairs in human, mouse for F7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat F7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for F7 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F71 , 5 coagulation factor VII1, 5 76.96(n)1
    71.62(a)1
      8 (5.73 cM)5
    140681  NM_010172.31  NP_034302.21 
     130260345 
    chicken
    (Gallus gallus)
    Aves F71 coagulation factor VII (serum prothrombin conversion more 59.68(n)
    57.11(a)
      395086  NM_204442.1  NP_989773.1 
    lizard
    (Anolis carolinensis)
    Reptilia F76
    coagulation factor VII (serum prothrombin conversi...
    55(a)
    1 ↔ 1
    3(105930562-105943454)
    zebrafish
    (Danio rerio)
    Actinopterygii AY040345.12   -- 72.42(n)   114423  AY040345.1 


    ENSEMBL Gene Tree for F7 (if available)
    TreeFam Gene Tree for F7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F7 gene
    PAMR12  PROZ2  C1S2  C1R2  C1RL2  F92  F102  MASP12  
    F22  HPR2  PROC2  HP2  MASP22  
    18/55 SIMAP similar genes for F7 using alignment to 6 protein entries:     FA7_HUMAN (see all proteins) (see all similar genes):
    F2    FBLN1    F9    PROC1    DKFZp586F0824    F12
    FBN2    GAS6    MATN2    SNED1    HP    EGFL7
    F9 p22    factor IX F9    F10    PROC    TRY8    PRSS1

    F7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/750 SNPs in F7 are shown (see all 750)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0654104
    Factor VII deficiency (FA7D)4--see VAR_0654102 T M mis40--------
    VAR_0065164
    Factor VII deficiency (FA7D)4--see VAR_0065162 G R mis40--------
    VAR_0653734
    Factor VII deficiency (FA7D)4--see VAR_0653732 E K mis40--------
    VAR_0654174
    Factor VII deficiency (FA7D)4--see VAR_0654172 S N mis40--------
    VAR_0144124
    Factor VII deficiency (FA7D)4--see VAR_0144122 C R mis40--------
    VAR_0065074
    Factor VII deficiency (FA7D)4--see VAR_0065072 R W mis40--------
    VAR_0653834
    Factor VII deficiency (FA7D)4--see VAR_0653832 S F mis40--------
    VAR_0064974
    Factor VII deficiency (FA7D)4--see VAR_0064972 R K mis40--------
    VAR_0654254
    Factor VII deficiency (FA7D)4--see VAR_0654252 A T mis40--------
    VAR_0065174
    Factor VII deficiency (FA7D)4--see VAR_0065172 G E mis40--------

    HapMap Linkage Disequilibrium report for F7 (113760105 - 113774995 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for F7 (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748250CNV Deletion23290073
    esv2748259CNV Deletion23290073
    esv2748244CNV Deletion23290073
    esv5028CNV Deletion18987735
    esv2748245CNV Deletion23290073
    esv2748248CNV Deletion23290073
    esv2748247CNV Deletion23290073
    esv2748260CNV Deletion23290073
    esv2748249CNV Deletion23290073
    esv2748258CNV Deletion23290073


    Human Gene Mutation Database (HGMD): F7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing F7
    DNA2.0 Custom Variant and Variant Library Synthesis for F7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613878    OMIM disorders: --

    UniProtKB/Swiss-Prot: FA7_HUMAN, P08709
  • Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical
    picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or,
    in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a
    surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/79 diseases for F7 (see all 79):    About MalaCards
    factor vii deficiency    factor v deficiency    ischemic heart disease    vitamin k deficiency hemorrhagic disease
    dubin-johnson syndrome    coronary heart disease    factor viii deficiency    factor x deficiency
    hemophilia    factor xi deficiency    chronic myeloproliferative disease    carotid stenosis
    hemorrhagic disease    acute liver failure    von willebrand's disease    hemophilia b
    blood clots    thromboembolism    cerebral palsy    protein c deficiency

    15 diseases from the University of Copenhagen DISEASES database for F7:
    Factor VII deficiency     Heart disease     Disseminated intravascular coagulation     Factor XI deficiency
    Hemophilia B     Glanzmann's thrombasthenia     Von Willebrand's disease     Cerebrovascular accident
    Vitamin K deficiency hemorrhagic disease     Factor X deficiency     Atherosclerosis     Liver disease
    Thrombocytopenia     Factor VIII deficiency     Diabetes mellitus

    F7 for disorders           About GeneDecksing

    10/31 Novoseek inferred disease relationships for F7 gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    factor vii deficiency 91 16 1666726 (3), 8844208 (2), 16792912 (1), 12695753 (1) (see all 13)
    coronary heart disease 52.6 8 11372669 (2), 17581323 (1), 9301633 (1), 15081566 (1) (see all 7)
    coagulopathy 52 2 11202627 (1), 15734783 (1)
    thrombosis 45.2 10 18282149 (2), 8086403 (1), 9301633 (1), 11143761 (1) (see all 9)
    myocardial infarction 42.1 11 12935410 (1), 11578716 (1), 11776135 (1), 17059418 (1) (see all 11)
    cardiovascular diseases 41.6 7 9187410 (1), 9308739 (1), 10828024 (1), 17059418 (1) (see all 7)
    hemophilia a 37.3 2 10087434 (2)
    thrombophilia 35.8 3 15771687 (1), 16292673 (1)
    von willebrand disease 27.8 1 9885217 (1)
    intracranial hemorrhages 24.7 1 10087434 (1)

    Genatlas disease: F7
    hypoproconvertinemia

    Genetic Association Database (GAD): F7
    Human Genome Epidemiology (HuGE) Navigator: F7 (156 documents)

    Export disorders for F7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F7 gene, integrated from 9 sources (see all 578) (see top 10):
    (articles sorted by number of sources associating them with F7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. (PubMed id 18976247)1, 2, 4 Herrmann F.H....Salazar-Sanchez L. (2008)
    2. Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2- Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z. (PubMed id 2511201)1, 2, 3 Nishimura H.... Iwanaga S. (1989)
    3. Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells. (PubMed id 3264725)1, 2, 3 Thim L.... Hedner U. (1988)
    4. Human F7 sequence is split into three deep clades that are related to FVII plasma levels. (PubMed id 16292673)1, 2, 9 Sabater-Lleal M.... Calafell F. (2006)
    5. Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women. (PubMed id 17059418)1, 4, 9 Reiner A.P....Nickerson D.A. (2007)
    6. Molecular analysis of the genotype-phenotype relationship in factor VII deficiency. (PubMed id 11129332)1, 2, 9 Millar D.S.... Cooper D.N. (2000)
    7. The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study. (PubMed id 19415820)1, 4, 9 Maitland-van der Zee A.H....Eckfeldt J.H. (2009)
    8. [The connection between Arg353Gln polymorphism of coagulation factor VII and recurrent miscarriages] (PubMed id 19323053)1, 4, 9 Seremak-Mrozikiewicz A....Mrozikiewicz P.M. (2009)
    9. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. (PubMed id 17008590)1, 4, 9 Campo G....Bernardi F. (2006)
    10. Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease. (PubMed id 15081566)1, 4, 9 Lindman A.S....Seljeflot I. (2004)
    11. Mutation pattern in clinically asymptomatic coagulation factor VII deficiency. (PubMed id 8844208)1, 2, 9 Bernardi F.... Marchetti G. (1996)
    12. Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII. (PubMed id 8242057)1, 2, 9 Takamiya O.... McVey J.H. (1993)
    13. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4, 9 Drenos F....Hingorani A.D. (2009)
    14. Coagulation factor VII and inflammatory markers in patients with coronary heart disease. (PubMed id 17581323)1, 4, 9 Ekstrom M....Tornvall P. (2007)
    15. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. (PubMed id 16614319)1, 4, 9 Kathiresan S....O'Donnell C.J. (2006)
    16. The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus. (PubMed id 16596941)1, 4, 9 Soria J.M....Blangero J. (2005)
    17. Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise training. (PubMed id 14766762)1, 4, 9 Ghiu I.A....Hagberg J.M. (2004)
    18. Polymorphisms of the coagulation factor VII gene and its plasma levels in relation to acute cerebral infarction differences in allelic frequencies between Chinese Han and European populations. (PubMed id 14733777)1, 4, 9 Kang W.Y....Wang Z.Y. (2004)
    19. The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene. (PubMed id 15175795)1, 4, 9 Lindman A.S....Seljeflot I. (2004)
    20. Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography. (PubMed id 12935410)1, 4, 9 Xu G....Shan J. (2003)
    21. [Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart disease] (PubMed id 12482354)1, 4, 9 Kang W....Wang Z. (2002)
    22. Coagulation factor VII activity, Arg/Gln353 polymorphism and features of insulin resistance in first-degree-relatives of South Asian patients with stroke. (PubMed id 12529745)1, 4, 9 Kain K....Grant P.J. (2002)
    23. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease. (PubMed id 10984565)1, 2, 9 Girelli D.... Corrocher R. (2000)
    24. Topologically equivalent mutations causing dysfunctional coagulation factors VII (294Ala-->Val) and X (334Ser-->Pro). (PubMed id 7981691)1, 2, 9 Bernardi F.... Marchetti G. (1994)
    25. Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7). (PubMed id 1634227)1, 2, 9 Marchetti G.... Bernardi F. (1992)
    26. Recurrent mutations and genotype-phenotype correlations in hereditary factor VII deficiency in Korea. (PubMed id 21206266)1, 2 Kwon M.J.... Kim H.J. (2011)
    27. Association of ACE and FACTOR VII gene variability wi th the risk of coronary heart disease in north Indian population. (PubMed id 20364300)1, 4 Sobti R.C....Talwar K.K. (2010)
    28. No significant association between the promoter regio n polymorphisms of factor VII gene and risk of venous thrombosis in cancer pati ents. (PubMed id 20332763)1, 4 EroA9lu A....Akar N. (2010)
    29. Polymorphisms in the factor VII gene and ischemic str oke in young adults. (PubMed id 20453637)1, 4 Lopaciuk S....Bauer K.A. (2010)
    30. Study of 18 functional hemostatic polymorphisms in mu cocutaneous bleeding disorders. (PubMed id 20532885)1, 4 AntA^n A.I....Mezzano D. (2010)
    31. Association of factor VII gene polymorphisms with Bud d Chiari syndrome. (PubMed id 20351643)1, 4 Jain A....Ghosh K. (2010)
    32. Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction. (PubMed id 20036902)1, 4 Musino L....Carru C. (2010)
    33. Lack of association between FXIII-Val34Leu, FVII-323 del/ins, and transforming growth factor beta1 (915G/T) gene polymorphisms and b ronchopulmonary dysplasia: a single-center study. (PubMed id 19778283)1, 4 AtaAs F.B....Ozbek N. (2010)
    34. Different evolutionary histories of the coagulation f actor VII gene in human populations? (PubMed id 20059471)1, 4 Athanasiadis G....Moral P. (2010)
    35. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    36. Two polymorphisms of the FVII gene and their impact o n the risk of myocardial infarction in poles under 45 years of age. (PubMed id 20586182)1, 4 Sakowicz A....Pietrucha T. (2010)
    37. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    38. Causal relationship of susceptibility genes to ischem ic stroke: comparison to ischemic heart disease and biochemical determinants. (PubMed id 20161734)1, 4 Bentley P....Sharma P. (2010)
    39. Independent predictive roles of eotaxin Ala23Thr, par aoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on car diac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (2010)
    40. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    41. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    42. Synergism between factor XII -4C>T and factor XIII Val34Leu polymorphisms in fibrinolytic therapy in acute myocardial infarction. (PubMed id 20589311)1, 4 HernA!ndez-Romero D....GonzA!lez-Conejero R. (2010)
    43. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    44. Temporal and genotype-driven variation of factor VII levels in patients with acute myocardial infarction. (PubMed id 19150996)1, 4 Ferraresi P....Bernardi F. (2009)
    45. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    46. Exploring warfarin pharmacogenomics with the extreme-discordant-phenotype methodology: impact of FVII polymorphisms on stable anticoagulation with warfarin. (PubMed id 19387626)1, 4 Fuchshuber-Moraes M....Suarez-Kurtz G. (2009)
    47. Phenotypic and genotypic characterization of Factor V II deficiency patients from Western India. (PubMed id 19751712)1, 2 Mota L....Ghosh K. (2009)
    48. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PubMed id 19479237)1, 4 Song X.Y....Chan J.C. (2009)
    49. Clinical factors such as B-type natriuretic peptide l ink to factor VII, endothelial NO synthase and estrogen receptor alpha polymorp hism in elderly women. (PubMed id 19560472)1, 4 Funami J....Iguchi A. (2009)
    50. Polymorphism in factor VII gene modifies phenotype of severe haemophilia. (PubMed id 19686262)1, 4 Jayandharan G.R....Srivastava A. (2009)
    51. A candidate gene association study of 77 polymorphism s in migraine. (PubMed id 19559392)1, 4 SchA1rks M....Zee R.Y. (2009)
    52. Genetic determinants of warfarin dosing in the Han-Ch inese population. (PubMed id 19958090)1, 4 Lee M.T....Chen Y.T. (2009)
    53. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. (PubMed id 19263529)1, 4 Zee R.Y....Glynn R.J. (2009)
    54. Familial factor VII deficiency with foetal and neonat al fatal cerebral haemorrhage associated with homozygosis to Gly180Arg mutation . (PubMed id 19432927)1, 2 Landau D....Kapelushnik J. (2009)
    55. Perioperative genomic profiles using structure-specif ic oligonucleotide probes. (PubMed id 19474452)1, 4 Hogan K.J....Domanico M.J. (2009)
    56. Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1, 4 Matarin M....Meschia J.F. (2009)
    57. [The coagulation factor VII gene polymorphisms in pat ients with myocardial infarction in Ningxia Hui and Han populations] (PubMed id 19953488)1, 4 Huang H....He L. (2009)
    58. Genotype-phenotype relationship of F7 R353Q polymorph ism and plasma factor VII coagulant activity in Asian Indian families predispos ed to coronary artery disease. (PubMed id 20086294)1, 4 Shanker J....Kakkar V.V. (2009)
    59. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. (PubMed id 19131662)1, 4 Wang X....Cook N.R. (2009)
    60. The genomic basis of cerebral palsy: a HuGE systematic literature review. (PubMed id 19238444)1, 4 O'Callaghan M.E....Dekker G. (2009)
    61. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1, 4 Silander K....Peltonen L. (2008)
    62. Genetic profile of ischemic cerebrovascular disease and carotid stenosis. (PubMed id 18325076)1, 4 Kostulas K....Hillert J. (2008)
    63. Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis. (PubMed id 18253477)1, 4 Martinelli N....Girelli D. (2008)
    64. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    65. Lp(a) and Risk of Recurrent Cardiac Events in Obese Postinfarction Patients. (PubMed id 18927546)1, 4 Corsetti J.P....Sparks C.E. (2008)
    66. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (2008)
    67. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PubMed id 18513389)1, 4 Penco S....Grossi E. (2008)
    68. Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis. (PubMed id 18403734)1, 4 Maguire J.M....Attia J. (2008)
    69. Candidate genes and cerebral palsy: a population-based study. (PubMed id 18977990)1, 4 Gibson C.S....Nelson K.B. (2008)
    70. Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction. (PubMed id 18284606)1, 4 van der Krabben M.D....Doggen C.J. (2008)
    71. Factor VII, blood lipids and fat intake: gene-nutrient interaction and risk of coronary heart disease with the factor VII R353Q polymorphism. (PubMed id 18398422)1, 4 Bowman R....Bingham S.A. (2008)
    72. Factor VII -323 decanucleotide D/I polymorphism in atrial fibrillation: Implications for the prothrombotic state and stroke risk. (PubMed id 18608122)1, 4 Roldan V....Vicente V. (2008)
    73. A two adenine insertion polymorphism in the 3' untranslated region of factor VII gene is associated with peripheral arterial disease but not with venous thrombosis. Results of case-control studies. (PubMed id 17938795)1, 4 Serve E....Tapon-Bretaudiere J. (2007)
    74. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. (PubMed id 16472842)1, 4 Taymaz H....Kirdar B. (2007)
    75. The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol. (PubMed id 17596133)1, 4 Gonzalez-Conejero R....Vicente V. (2007)
    76. The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions. (PubMed id 18064331)1, 4 Pons D....Jukema J.W. (2007)
    77. Polymorphisms of the factor VII gene associated with the low activities of vitamin K-dependent coagulation factors in one-month-old infants. (PubMed id 17202767)1, 4 Ito K....Togari H. (2007)
    78. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (2007)
    79. Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolism. (PubMed id 17663738)1, 4 Folsom A.R....Tsai M.Y. (2007)
    80. Polymorphisms in the coagulation factor VII gene and risk of primary intracerebral hemorrhage. (PubMed id 17880564)1, 4 Greisenegger S....Mannhalter C. (2007)
    81. Association of warfarin dose with genes involved in its action and metabolism. (PubMed id 17048007)1, 4 Wadelius M....Deloukas P. (2007)
    82. Factor VII polymorphisms influence the plasma response to diets with different fat content, in a healthy Caucasian population. (PubMed id 17440998)1, 4 Fernandez de la Puebla R.A....Perez-Jimenez F. (2007)
    83. The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men. (PubMed id 17488662)1, 4 Navarro-Nunez L....Martinez C. (2007)
    84. The influence of sequence variations in factor VII, gamma-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement. (PubMed id 16676068)1, 4 Herman D....Dolzan V. (2006)
    85. The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns. (PubMed id 17044869)1, 4 Quek S.C....Heng C.K. (2006)
    86. Factor VII gene haplotypes and risk of ischemic stroke. (PubMed id 16556685)1, 4 Funk M....Mannhalter C. (2006)
    87. Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements. (PubMed id 16580898)1, 4 Aquilante C.L....Johnson J.A. (2006)
    88. Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica. (PubMed id 18457169)1, 4 Salazar-Sanchez L....Herrmann F.H. (2006)
    89. Marburg I polymorphism of factor VII-activating protease and risk of recurrent venous thromboembolism. (PubMed id 16543963)1, 4 Gulesserian T....Kyrle P.A. (2006)
    90. Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population. (PubMed id 17003923)1, 4 Hoppe B....Salama A. (2006)
    91. Genetic polymorphisms of hemostasis genes and primary outcome of very low birth weight infants. (PubMed id 16882823)1, 4 Hartel C....Gopel W. (2006)
    92. [Plasma activated coagulation factor VI and Msp I polymorphism in elderly patients with coronary heart disease] (PubMed id 16331575)1, 4 Lu Q.H....Shang Q. (2005)
    93. Coagulation gene polymorphisms as risk factors for myocardial infarction in young Indian Asians. (PubMed id 16049588)1, 4 Pegoraro R.J....Rom L. (2005)
    94. Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. (PubMed id 16100725)1, 4 Shaw G.M....Lammer E.J. (2005)
    95. [Genetic factors of risk of ischemic heart disease development in patients with familial hypercholesterolemia] (PubMed id 16091654)1, 4 Meshkov A.N....Malyshev P.P. (2005)
    96. A protective contribution of the Q allele of the R353Q polymorphism of the Factor VII gene in individuals with chronic stable angina? (PubMed id 15837082)1, 4 Jeffery S....Kaski J.C. (2005)
    97. Factor VII polymorphisms associated with plasma factor VII coagulant activity levels in healthy Tunisians. (PubMed id 16532678)1, 4 Nour M....Mahjoub T. (2005)
    98. Prolonged prothrombin time, Factor VII and activated FVII levels in chronic liver disease are partly dependent on Factor VII gene polymorphisms. (PubMed id 15893284)1, 4 Grimaudo S....Mariani G. (2005)
    99. Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease. (PubMed id 15711754)1, 4 Eriksson-Berg M....Hamsten A. (2005)
    100. Clinical phenotypes and factor VII genotype in congenital factor VII deficiency. (PubMed id 15735798)1, 4 Mariani G....Bernardi F. (2005)
    101. Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. (PubMed id 15621215)1, 4 Stessman J....Ebstein R.P. (2005)
    102. [Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age] (PubMed id 16353042)1, 4 Dankovtseva E.N....Sidorenko B.A. (2005)
    103. Reduction in coagulation factor VII plasma levels by R353Q but not the -323P0/10 promoter polymorphism in healthy Tunisians. (PubMed id 15952268)1, 4 Mtiraoui N....Mahjoub T. (2005)
    104. Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population. (PubMed id 15968394)1, 4 Rubattu S....Volpe M. (2005)
    105. Genetic polymorphisms and cerebral palsy in very preterm infants. (PubMed id 15718364)1, 4 Nelson K.B....Lammer E. (2005)
    106. Elevated factor VII as a risk factor for recurrent fetal loss. Relationship to factor VII gene polymorphisms. (PubMed id 15968393)1, 4 Miller C.H....Philipp C.S. (2005)
    107. Prognosis of young ischemic stroke in Taiwan: impact of prothrombotic genetic polymorphisms. (PubMed id 15351855)1, 4 Yeh P.S....Ke D.S. (2004)
    108. Prevalence in a Tunisian Arabic population of factor VII DNA variants and relation to factor VII plasma levels. (PubMed id 15469874)1, 4 Nour M....Helal A.N. (2004)
    109. R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men. (PubMed id 15170085)1, 4 Ogawa M....Tei C. (2004)
    110. Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosis. (PubMed id 15351850)1, 4 Bozzini C....Corrocher R. (2004)
    111. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    112. Association between factor VII polymorphisms and blood pressure: the Stanislas Cohort. (PubMed id 15452029)1, 4 Sass C....Visvikis-Siest S. (2004)
    113. Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study. (PubMed id 14963283)1, 4 Fox C.S....O'Donnell C.J. (2004)
    114. Effect of the factor VII R353Q missense mutation on plasma apolipoprotein B levels: impact of visceral obesity. (PubMed id 12851844)1, 4 Berthier M.T....Vohl M.C. (2003)
    115. Molecular variation at functional genes and the history of human populations--data on candidate genes for cardiovascular risk in the Mediterranean. (PubMed id 14746139)1, 4 Moral P....Vona G. (2003)
    116. Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction. (PubMed id 12859287)1, 4 Petrovic D....Peterlin B. (2003)
    117. A functional haplotype in the 5' flanking region of the factor VII gene is associated with an increased risk of coronary heart disease. (PubMed id 14521602)1, 4 Carew J.A....Bauer K.A. (2003)
    118. No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. (PubMed id 12615788)1, 4  . (2003)
    119. [Association of coagulation factor V, VII gene polymorphisms with coronary heart disease] (PubMed id 12579498)1, 4 Xu G....Shan J. (2003)
    120. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PubMed id 12768436)1, 4 Lee J.K....Jo I. (2003)
    121. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. (PubMed id 12871600)1, 4 Adams G.T....Kutlar A. (2003)
    122. Association of beta-fibrinogen and factor VII polymorphism with plasma fibrinogen and factor VII levels, and no association of PAI-1 polymorphism with plasma PAI-1 levels in hemodialysis patients. (PubMed id 12141403)1, 4 Ando R....Tomura S. (2002)
    123. Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction. (PubMed id 12616980)1, 4 Bloemenkamp K.W....Kluft C. (2002)
    124. Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese. (PubMed id 11943935)1, 4 Liu Y....Low P.S. (2002)
    125. Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease. (PubMed id 12446192)1, 4 Ortlepp J.R....Hoffmann R. (2002)
    126. Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese: Factor VII polymorphism and coronary disease. (PubMed id 12091048)1, 4 Shimokata K....Hirai M. (2002)
    127. Polymorphisms of genes affecting thrombosis and risk of myocardial infarction. (PubMed id 12486862)1, 4 Kakko S....Savolainen M.J. (2002)
    128. Fibrinogen and factor VII promoter polymorphisms in women with preeclampsia. (PubMed id 12151156)1, 4 Laasanen J....Heinonen S. (2002)
    129. Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. (PubMed id 12082592)1, 4 Zee R.Y....Lindpainter K. (2002)
    130. Utility of the Arg/Gln polymorphism of the factor VII (FVII) gene, serum lipid levels and body mass index in the prediction of the FVII:C and FVII:Ag in North Karelia; a cross-sectional and prospective study. (PubMed id 11555697)1, 4 Stengard J.H....Vartiainen E. (2001)
    131. Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases. (PubMed id 11397354)1, 4 Wu A.H. and Tsongalis G.J. (2001)
    132. Joint effect of G1691A factor V point mutation and factor VII Arg/Gln(353) gene polymorphism on the risk of premature coronary artery disease. (PubMed id 11334615)1, 4 Petrovic D....Peterlin B. (2001)
    133. Two novel factor VII gene mutations in a Chinese family with factor VII deficiency. (PubMed id 11091194)1, 2 Au W.Y.... Kwong Y.L. (2000)
    134. Twenty two novel mutations of the factor VII gene in factor VII deficiency. (PubMed id 10862079)1, 2 Wulff K. and Herrmann F.H. (2000)
    135. Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men. (PubMed id 11044420)1, 4 Zito F....Miller G.J. (2000)
    136. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (1999)
    137. Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant. (PubMed id 9925787)1, 2 Zhang E.... Tulinsky A. (1999)
    138. Prothrombotic genetic risk factors in patients with coexisting migraine and ischemic cerebrovascular disease. (PubMed id 11279932)1, 4 Iniesta J.A....Vicente V. (1999)
    139. Factor VII Morioka (FVII L-26P): a homozygous missense mutation in the signal sequence identified in a patient with factor VII deficiency. (PubMed id 9576180)1, 2 Ozawa T....Sakuragawa N. (1998)
    140. Solution structure of the N-terminal EGF-like domain from human factor VII. (PubMed id 9692950)1, 2 Muranyi A....Drakenberg T. (1998)
    141. A Thr359Met mutation in factor VII of a patient with a hereditary deficiency causes defective secretion of the molecule. (PubMed id 8652821)1, 2 Arbini A.A.... Bauer K.A. (1996)
    142. Ala244Val is a common, probably ancient mutation causing factor VII deficiency in Moroccan and Iranian Jews. (PubMed id 8883260)1, 2 Tamary H....Seligsohn U. (1996)
    143. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. (PubMed id 8598903)1, 2 Banner D.W.... Kirchhofer D. (1996)
    144. Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor. (PubMed id 8204879)1, 2 Chaing S.... High K.A. (1994)
    145. Factor VII Mie: homozygous asymptomatic type I deficiency caused by an amino acid substitution of His (CAC) for Arg(247) (CGC) in the catalytic domain. (PubMed id 7974346)1, 2 Ohiwa M.... Suzuki K. (1994)
    146. A common Ser/Thr polymorphism in the perforin-homologous region of human complement component C7. (PubMed id 7860081)1, 2 Dewald G.... Ruther K. (1994)
    147. A missense mutation (178Cys-->Tyr) and two neutral dimorphisms (115His and 333Ser) in the human coagulation factor VII gene. (PubMed id 8364544)1, 2 Marchetti G.... Bernardi F. (1993)
    148. Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male. (PubMed id 2070047)1, 2 O'Brien D.P.... Tuddenham E.G.D. (1991)
    149. Human plasma and recombinant factor VII. Characterization of O- glycosylations at serine residues 52 and 60 and effects of site- directed mutagenesis of serine 52 to alanine. (PubMed id 1904059)1, 2 Bjoern S.... Kisiel W. (1991)
    150. A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z. (PubMed id 2129367)1, 2 Iwanaga S.... Ikenaka T. (1990)
    151. Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation. (PubMed id 3037537)1, 2 O'Hara P.J.... Murray M.J. (1987)
    152. Characterization of a cDNA coding for human factor VII. (PubMed id 3486420)1, 2 Hagen F.S....Davie E.W. (1986)
    153. Using a minigene approach to characterize a novel spl ice site mutation in human F7 gene causing inherited factor VII deficiency in a Chinese pedigree. (PubMed id 19601987)1, 9 Yu T....Wang H. (2009)
    154. Impaired secretion of carboxyl-terminal truncated fac tor VII due to an F7 nonsense mutation associated with FVII deficiency. (PubMed id 19822353)1, 9 Tanaka R....Kojima T. (2010)
    155. High-level expression of functional recombinant human coagulation factor VII in insect cells. (PubMed id 20213530)1, 9 Masroori N....Roudkenar M.H. (2010)
    156. Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor. (PubMed id 17901076)1, 9 O'Brien M....Smith T.J. (2008)
    157. More than one intracellular processing bottleneck delays the secretion of coagulation factor VII. (PubMed id 18690338)1, 9 Bolt G....Steenstrup T.D. (2008)
    158. All post-translational modifications except propeptide cleavage are required for optimal secretion of coagulation factor VII. (PubMed id 18000603)1, 9 Bolt G....Kristensen C. (2007)
    159. Age estimates of ancestral mutations causing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations. (PubMed id 17287630)1, 9 Mor-Cohen R....Seligsohn U. (2007)
    160. Posttranslational N-glycosylation takes place during the normal processing of human coagulation factor VII. (PubMed id 15616124)1, 9 Bolt G....Steenstrup T.D. (2005)
    161. Two double heterozygous mutations in the F7 gene show different manifestations. (PubMed id 12472587)2, 9 Nagaizumi K....Fukutake K. (2002)
    162. Novel associations of multiple genetic loci with plas ma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Co horts for Heart and Aging Research in Genome Epidemiology) Consortium. (PubMed id 20231535)1, 9 Smith N.L.... C.J. (2010)
    163. Self-production of tissue factor-coagulation factor V II complex by ovarian cancer cells. (PubMed id 19904262)1, 9 Yokota N....Miyagi Y. (2009)
    164. Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting s elective histone acetyltransferases. (PubMed id 19996301)1, 9 Koizume S....Miyagi Y. (2009)
    165. Variability of clinical manifestation of factor VII-deficiency in homozygous and heterozygous subjects of the European F7 gene mutation A294V. (PubMed id 18556408)1, 9 Herrmann F.H....Schulman S. (2008)
    166. Mass spectrometric characterization of N- and O-glycans of plasma-derived coagulation factor VII. (PubMed id 18642129)1, 9 Fenaille F....Bihoreau N. (2008)
    167. CCAAT/enhancer-binding protein-beta participates in insulin-responsive expression of the factor VII gene. (PubMed id 17675296)1, 9 Jackson A.A....Carew J.A. (2007)
    168. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. (PubMed id 17018600)1, 9 Koizume S....Miyagi Y. (2006)
    169. Characterization of mild coagulation factor VII deficiency: activity and clearance of the Arg315Trp and Arg315Lys variants in the Cys310-Cys329 loop (c170s). (PubMed id 15590402)1, 9 Furlan Freguia C....Bernardi F. (2004)
    170. Similar molecular interactions of factor VII and factor VIIa with the tissue factor region that allosterically regulates enzyme activity. (PubMed id 14756558)1, 9 Kelley R.F....Kirchhofer D. (2004)
    171. A novel gene mutation in the 60s loop of human coagulation factor VII - inhibition of interdomain crosstalk. (PubMed id 14691565)1, 9 Kavlie A....Prydz H. (2004)
    172. [Inherited coagulation factor VII deficiency caused by double heterozygotic mutations Arg304Gln and Arg304Trp] (PubMed id 12903033)1, 9 Ding Q.L....Wang Z.Y. (2003)
    173. Factor VII gene intronic mutation in a lethal factor VII deficiency: effects on splice-site selection. (PubMed id 12676783)1, 9 Borensztajn K....Tapon-Bretaudiere J. (2003)
    174. A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates. (PubMed id 11931672)1, 9 Toso R....Bernardi F. (2002)
    175. Lack of association between polymorphisms of the coagulation factor VII and myocardial infarction in middle-aged Spanish men. (PubMed id 11578716)4, 9 Batalla A....Coto E. (2001)
    176. Orphan nuclear receptor HNF-4 binds to the human coagulation factor VII promoter. (PubMed id 7559437)1, 9 Erdmann D. and Heim J. (1995)
    177. Risk of venous thromboembolism and myocardial infarcti on associated with factor V Leiden and prothrombin mutations and blood type. (PubMed id 23382263)1 Sode B.F....Nordestgaard B.G. (2013)
    178. Ribavirin-induced intracellular GTP depletion activate s transcription elongation in coagulation factor VII gene expression. (PubMed id 23050902)1 Suzuki A....Kojima T. (2013)
    179. Rab GTPases regulate endothelial cell protein C recept or-mediated endocytosis and trafficking of factor VIIa. (PubMed id 23555015)1 Nayak R.C....Rao L.V. (2013)
    180. A recombinant adenovirus vector encoding the light cha in of human coagulation factor VII and IgG1 Fc fragment to targeting tissue fact or for colorectal cancer immunotherapy in the mouse model. (PubMed id 23494077)1 Rao B....Wang J. (2013)
    181. Structural and functional studies of g-carboxyglutamic acid domains of factor VIIa and activated Protein C: role of magnesium at physi ological calcium. (PubMed id 23454357)1 Vadivel K....Bajaj S.P. (2013)
    182. Factor VIIa-antithrombin complexes in patients with no n-neoplastic portal vein thrombosis with and without cirrhosis. (PubMed id 22958499)1 Rossetto V....Simioni P. (2013)
    183. Tissue factor de-encryption, thrombus formation, and t hiol-disulfide exchange. (PubMed id 23325480)1 Chen V.M. (2013)
    184. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. (PubMed id 23381943)1 Williams F.M.... . (2013)
    185. A new regulatory function of activated factor V: inhib ition of the activation by tissue factor/factor VII(a) of factor X. (PubMed id 23294934)1 Al Dieri R....Hemker H.C. (2013)
    186. Factor VII levels, R353Q and -323P0/10 Factor VII vari ants, and the risk of acute coronary syndrome among Arab-African Tunisians. (PubMed id 23275237)1 Ben-Hadj-Khalifa S....Almawi W.Y. (2013)
    187. Identification of genetic defects underlying FVII defi ciency in 10 patients belonging to eight unrelated families of the North provinc es from Tunisia. (PubMed id 22873696)1 Elmahmoudi H....Gouider E. (2012)
    188. Lethal factor VII deficiency due to novel mutations in the F7 promoter: functional analysis reveals disruption of HNF4 binding site. (PubMed id 22628013)1 Giansily-Blaizot M....Taulan M. (2012)
    189. Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels. (PubMed id 22815813)1 El Shamieh S....Visvikis-Siest S. (2012)
    190. Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (2012)
    191. Factor VIIa binding to endothelial cell protein C rece ptor: differences between mouse and human systems. (PubMed id 22370814)1 Sen P....Rao L.V. (2012)
    192. Factor seven activating protease (FSAP): does it activ ate factor VII? (PubMed id 22235940)1 Stavenuiter F....Mertens K. (2012)
    193. Tissue factor/activated factor VIIa induces matrix met alloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. (PubMed id 22076613)1 Jia Z.C....Zhu J. (2012)
    194. Activation of a cryptic splice site in a potentially l ethal coagulation defect accounts for a functional protein variant. (PubMed id 22426302)1 Cavallari N....Pinotti M. (2012)
    195. Antibody-induced enhancement of factor VIIa activity t hrough distinct allosteric pathways. (PubMed id 22275370)1 Andersen L.M....Persson E. (2012)
    196. Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4. (PubMed id 22848420)1 Cronin K.R....Carew J.A. (2012)
    197. Pharmacokinetics, distribution, and excretion of 125I- labeled human plasma-derived-FVIIa and -FX with MC710 (FVIIa/FX mixture) in rats . (PubMed id 21621824)1 Nakatomi Y....Mogi M. (2012)
    198. Coagulation factor VII R353Q polymorphism and the risk of puerperal cerebral venous thrombosis. (PubMed id 22136731)1 Kruthika-Vinod T.P....Christopher R. (2012)
    199. Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. (PubMed id 22315437)1 Friso S....Olivieri O. (2012)
    200. Severe FX deficiency caused by a previously unidentifi ed 4-bp deletion compound heterozygous with a large deletion involving FVII and FX genes. (PubMed id 22126652)1 Tan C.W....Ward C.M. (2012)
    201. Influence of endothelial cell protein C receptor on pl asma clearance of factor VIIa. (PubMed id 22372829)1 Gopalakrishnan R....Rao L.V. (2012)
    202. Polymorphisms of genes encoding coagulation factors II , V, VII, and XIII in relation to pediatric ischemic stroke: family-based and ca se-control study. (PubMed id 22931734)1 Kopyta I.A....Pal/atynska K. (2012)
    203. [Molecular genetics and clinical features of nine pati ents with inherited coagulation factor VII deficiency]. (PubMed id 22875495)1 Jin Y.H....Xu P.F. (2012)
    204. Natural and engineered carboxy-terminal variants: decr eased secretion and gain-of-function result in asymptomatic coagulation factor V II deficiency. (PubMed id 22180436)1 Branchini A....Bernardi F. (2012)
    205. Relationships of plasma factor VIIa-antithrombin compl exes to manifest and future cardiovascular disease. (PubMed id 21925715)1 Silveira A....Hamsten A. (2012)
    206. Factor XIII and tranexamic acid but not recombinant fa ctor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in hu man whole blood. (PubMed id 22104068)1 Dirkmann D....Peters J. (2012)
    207. A gene-centric association scan for Coagulation Facto r VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. (PubMed id 21676895)1 Taylor K.C....Reiner A.P. (2011)
    208. GlycoPEGylated rFVIIa (N7-GP) has a prolonged hemosta tic effect in hemophilic mice compared with rFVIIa. (PubMed id 21366858)1 Holmberg H....Ezban M. (2011)
    209. Polycations selectively blocking tissue factor-depend ent FVII activation: collective in vitro anticoagulation studies. (PubMed id 21184651)1 Chu A.J. (2011)
    210. Factor VIIa-Antithrombin complexes during cardiac surg ery using cardiopulmonary bypass. (PubMed id 21569219)1 Davidson S.J. and Woodhams B. (2011)
    211. The association of genetic polymorphisms with cerebral palsy: a meta-analysis. (PubMed id 21291465)4 Wu D....Tang J.L. (2011)
    212. [Prophylactic use of a recombinant activated factor V II in delivery haemorrhage by caesarean in a woman with major factor VII defici ency: a case report]. (PubMed id 22123573)1 Comes J.F....Lecompte T. (2011)
    213. [An inherited coagulation factor VII deficiency pedig ree caused by homozygous mutation of His348Gln]. (PubMed id 21287501)1 Jin Y.H....Yang L.H. (2011)
    214. [Polymorphic markers Ala455Val of the THBD gene and A rg353Gln of the F7 gene and association with unfavorable outcomes of coronary a therosclerosis in patients with a history of acute ischemic heart disease]. (PubMed id 22232927)1 Pushkov A.A....Nosikov V.V. (2011)
    215. Plasma factor VII: a potential marker of pre-eclampsi a. (PubMed id 21094984)1 Dusse L.M....Lwaleed B.A. (2011)
    216. A novel missense mutation close to the charge-stabilizing system in a patient with congenital factor VII deficiency. (PubMed id 21372693)2 Jiang M.... Ruan C. (2011)
    217. Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a met a-analysis. (PubMed id 21838885)1 Mo X....Gu D. (2011)
    218. Factor VIIa bound to endothelial cell protein C recep tor activates protease activated receptor-1 and mediates cell signaling and bar rier protection. (PubMed id 21252088)1 Sen P....Rao L.V. (2011)
    219. Room-temperature-stable recombinant activated coagulat ion factor VII recombinant: chemical and microbiologic stability over 24 hours d uring continuous in vitro infusion. (PubMed id 22088413)1 Christensen A....Cooper D.L. (2011)
    220. Tissue factor-factor VIIa complex induces epithelial ovarian cancer cell invasion and metastasis through a monocytes-dependent mecha nism. (PubMed id 21543928)1 Ma Z....Wang X. (2011)
    221. Worldwide diffusion of FVII Arg304Gln coagulation def ect (FVII Padua). (PubMed id 20958793)1 Girolami A....Allemand E. (2011)
    222. Arg 304 Gln (FVII Padua) and Ala 294 Val mutations ar e equally present in patients with FVII deficiency and thrombosis. (PubMed id 21453389)1 Girolami A....Fabris F. (2011)
    223. Involvement of ERK1/2/NF-I_B signal transduction pathw ay in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW 620. (PubMed id 21625939)1 Guo D....Zhang X. (2011)
    224. Similarities and discrepancies in homozygous factor V II defects due to mutations in the region of residues Met298 to Cys310 (exon 8) in the catalytic domain of factor VII. (PubMed id 21705315)1 Girolami A....Vettore S. (2011)
    225. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    226. Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation. (PubMed id 21641634)1 Mitrophanov A.Y. and Reifman J. (2011)
    227. R353Q polymorphism in the factor VII gene and cardiov ascular risk in Heterozygous Familial Hypercholesterolemia: a case-control stud y. (PubMed id 21477332)1 Criado-GarcA-a J....PAcrez-JimAcnez F. (2011)
    228. Mutation in the factor VII hepatocyte nuclear factor 4I+-binding site contributes to factor VII deficiency. (PubMed id 21760481)1 Zheng X.W....Pollak E.S. (2011)
    229. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo. (PubMed id 21737124)1 Sidelmann J.J....Jespersen J. (2011)
    230. Current status on tissue factor activation of factor VIIa. (PubMed id 20153879)1 Persson E. and Olsen O.H. (2010)
    231. Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII. (PubMed id 20634491)1 Nadir Y.... Vlodavsky I. (2010)
    232. Interrelationships of Factor VII activity and plasma leptin with insulin resistance in coronary heart disease. (PubMed id 19781705)1 Karatela R.A. and Sainani G.S. (2010)
    233. Association between the -402GA, -401GT, and -323ins10 -bp polymorphisms of factor VII gene and breast cancer. (PubMed id 20107938)1 EroA9lu A....Akar N. (2010)
    234. Thromboembolic events with recombinant activated fact or VII in spontaneous intracerebral hemorrhage: results from the Factor Seven f or Acute Hemorrhagic Stroke (FAST) trial. (PubMed id 19959538)1 Diringer M.N....Broderick J.P. (2010)
    235. Chronic sleep deprivation markedly reduces coagulatio n factor VII expression. (PubMed id 20418241)1 Pinotti M....Tosini G. (2010)
    236. Factor VIIa interaction with endothelial cells and en dothelial cell protein C receptor. (PubMed id 20156643)1 Pendurthi U.R. and Rao L.V. (2010)
    237. Haplotype and genotype effects of the F7 gene on circ ulating factor VII, coagulation activation markers and incident coronary heart disease in UK men. (PubMed id 20735728)1 Ken-Dror G....Ireland H.A. (2010)
    238. Investigating clearance mechanisms for recombinant ac tivated factor VII in a perfused liver model. (PubMed id 20508904)1 Appa R.S....Christensen M.S. (2010)
    239. Relationships between sleep duration and von Willebra nd factor, factor VII, and fibrinogen: Whitehall II study. (PubMed id 20651279)1 Miller M.A....Cappuccio F.P. (2010)
    240. Hemophilic synovitis: factor VII and the potential ro le of extravascular factor VIIa. (PubMed id 20227556)1 Monahan P.E. and Sun J. (2010)
    241. Mechanisms of factor VIIa-catalyzed activation of fac tor VIII. (PubMed id 20735721)1 Soeda T....Shima M. (2010)
    242. Apixaban, a direct factor Xa inhibitor, inhibits tiss ue-factor induced human platelet aggregation in vitro: comparison with direct i nhibitors of factor VIIa, XIa and thrombin. (PubMed id 20589316)1 Wong P.C. and Jiang X. (2010)
    243. An association between clotting factor VII and caroti d intima-media thickness: the CARDIA study. (PubMed id 20466994)1 Green D....Liu K. (2010)
    244. Recent estimates of the structure of the factor VIIa (FVIIa)/tissue factor (TF) and factor Xa (FXa) ternary complex. (PubMed id 20156644)1 Lee C.J....Pedersen L.G. (2010)
    245. Ox brain versus rabbit brain thromboplastin assays ar e the best tool for a preliminary diagnosis of the Arg304Gln factor VII defect (FVII Padua). (PubMed id 21099211)1 Girolami A....Vettore S. (2010)
    246. Open-heart surgery in an infant with heterozygous fac tor VII deficiency. (PubMed id 20197348)1 Matsuhisa H....Ichida F. (2010)
    247. Tissue Factor-Factor VIIa complex induces cytokine ex pression in coronary artery smooth muscle cells. (PubMed id 20708733)1 Demetz G....Ott I. (2010)
    248. Associated prothrombotic conditions are probably resp onsible for the occurrence of thrombosis in almost all patients with congenital FVII deficiency. Critical review of the literature. (PubMed id 20044773)1 Girolami A....Girolami B. (2010)
    249. Pharmacogenetics of acenocoumarol in patients with ex treme dose requirements. (PubMed id 20149073)1 PAcrez-Andreu V....GonzA!lez-Conejero R. (2010)
    250. Extrahepatic synthesis of coagulation factor VII by co lorectal cancer cells promotes tumor invasion and metastasis. (PubMed id 22166631)1 Tang J.Q....Wan Y.L. (2010)
    251. BMS-593214, an active site-directed factor VIIa inhib itor: enzyme kinetics, antithrombotic and antihaemostatic studies. (PubMed id 20589312)1 Wong P.C....Priestley E.S. (2010)
    252. Engineering of substrate selectivity for tissue facto r.factor VIIa complex signaling through protease-activated receptor 2. (PubMed id 20388709)1 Larsen K.S....Petersen L.C. (2010)
    253. Characterization of canine coagulation factor VII and its complex formation with tissue factor: canine-human cross-species compatibi lity. (PubMed id 20524980)1 Knudsen T....Petersen L.C. (2010)
    254. Role of PDI in regulating tissue factor: FVIIa activi ty. (PubMed id 20163832)1 Popescu N.I....Lupu F. (2010)
    255. Impact of pharmacokinetic (CYP2C9) and pharmacodynami c (VKORC1, F7, GGCX, CALU, EPHX1) gene variants on the initiation and maintenan ce phases of phenprocoumon therapy. (PubMed id 21057703)1 Luxembourg B....Geisen C. (2010)
    256. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    257. The interaction of recombinant factor VIIa with plate let glycoprotein Ib. (PubMed id 20153024)1 Lisman T. and de Groot P.G. (2010)
    258. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    259. Endothelial cell protein C receptor cellular localiza tion and trafficking: potential functional implications. (PubMed id 19587380)1 Nayak R.C....Rao L.V. (2009)
    260. The influence of different glycosylation patterns on factor VII biological activity. (PubMed id 19524011)1 Sutkeviciute I....Bumelis V.A. (2009)
    261. Association of genetic variants with myocardial infar ction in Japanese individuals with chronic kidney disease. (PubMed id 19404551)1 Fujimaki T....Yamada Y. (2009)
    262. [Ectopic expression and clinical significance of tiss ue factor/coagulation factor VII complex in colorectal cancer] (PubMed id 19829668)1 Tang J.Q....Zhu J. (2009)
    263. [Distributions of polymorphisms of genes of some components of hemostasis in patients with ischemic heart disease] (PubMed id 19463111)4 (2009)
    264. Loop dynamics of the extracellular domain of human tissue factor and activation of factor VIIa. (PubMed id 19167313)1 Minazzo A.S....Ross J.B. (2009)
    265. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    266. Plasma elimination kinetics for factor VII are indepe ndent of its activation to factor VIIa and complex formation with plasma inhibi tors. (PubMed id 19404533)1 Petersen L.C....rensen B.B. (2009)
    267. Polymorphisms in VKORC1 and GGCX are not major geneti c determinants of vitamin K-dependent coagulation factor activity in Western Ge rmans. (PubMed id 19652895)1 Watzka M....Oldenburg J. (2009)
    268. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (2009)
    269. Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. (PubMed id 19167329)2 Ruiz-Canada C....Gilmore R. (2009)
    270. Molecular dynamics simulations and functional charact erization of the interactions of the PAR2 ectodomain with factor VIIa. (PubMed id 19536895)1 Zhang Q....Olson A.J. (2009)
    271. TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. (PubMed id 17991872)1 Siegbahn A....Velling T. (2008)
    272. Administration off label of recombinant factor-VIIa (rFVIIa) to patients with blunt or penetrating brain injury without coagulopathy. (PubMed id 18473114)1 Zaaroor M....Levi L. (2008)
    273. Investigation of 89 candidate gene variants for effect s on all-cause mortality following acute coronary syndrome. (PubMed id 18620593)4 Morgan T.M....Spertus J.A. (2008)
    274. Human FVII(K62E) does not exhibit enhanced binding to tissue factor. (PubMed id 18433457)1 Clarke B.J. and Blajchman M.A. (2008)
    275. Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity. (PubMed id 18640965)1 Bjelke J.R....Persson E. (2008)
    276. Improved clot formation by combined administration of activated factor VII (NovoSeven) and fibrinogen (Haemocomplettan P). (PubMed id 18292410)1 Tanaka K.A....Levy J.H. (2008)
    277. Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia. (PubMed id 18182033)1 Freeman D.J....Greer I.A. (2008)
    278. Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa. (PubMed id 18031796)1 Aberg M....Siegbahn A. (2008)
    279. Procoagulant activities of plasma factor VIIc and factor Xc are positively and independently associated with concentrations of the high-density lipoprotein apolipoprotein, apo A-II. (PubMed id 18766253)1 Atta M....Godsland I.F. (2008)
    280. U1-snRNA-mediated rescue of mRNA processing in severe factor VII deficiency. (PubMed id 18156490)1 Pinotti M....Pagani F. (2008)
    281. Antithrombin affects hemostatic response to recombinant activated factor VII in factor VIII deficient plasma. (PubMed id 18292408)1 Szlam F....Tanaka K.A. (2008)
    282. Adenovirus serotype 5 hexon mediates liver gene transfer. (PubMed id 18267072)1 Waddington S.N....Baker A.H. (2008)
    283. The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface. (PubMed id 18612104)1 Weeterings C....Lisman T. (2008)
    284. Study of factor VII, tissue factor pathway inhibitor and monocyte tissue factor in noninsulin-dependent diabetes mellitus. (PubMed id 18180609)1 El-Ghoroury E.A....Ragab S. (2008)
    285. The association between vascular function-related genes and age at natural menopause. (PubMed id 18030173)1 van Disseldorp J....van der Schouw Y.T. (2008)
    286. Formation of tissue factor-factor VIIa-factor Xa complex induces activation of the mTOR pathway which regulates migration of human breast cancer cells. (PubMed id 18612547)1 Jiang X....Bromberg M.E. (2008)
    287. Tissue factor trafficking in fibroblasts: involvement of protease-activated receptor-mediated cell signaling. (PubMed id 17384202)1 Mandal S.K....Rao L.V. (2007)
    288. Linkage analysis for three coagulation factors clustering on chromosome 13q34: factor VII, factor X and protein Z. (PubMed id 17403098)1 Vossen C.Y....Bovill E.G. (2007)
    289. Seminal factor VII and factor VIIa: supporting evidence for the presence of an active tissue factor-dependent coagulation pathway in human semen. (PubMed id 17459125)1 Lwaleed B.A....Cooper A.J. (2007)
    290. Molecular basis of hereditary factor VII deficiency in India: five novel mutations including a double missense mutation (Ala191Glu; Trp364Cys) in 11 unrelated patients. (PubMed id 17606459)1 Jayandharan G.R....Srivastava A. (2007)
    291. Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia. (PubMed id 18000605)1 Gentile N.T....Rao A.K. (2007)
    292. Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa. (PubMed id 17456045)1 Larsen K.S....Stennicke H.R. (2007)
    293. Molecular analysis in a patient with severe factor VII deficiency and an inhibitor: report of a novel mutation (S103G). (PubMed id 17692102)1 Pruthi R.K....Plumhoff E.A. (2007)
    294. Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells. (PubMed id 17470200)1 Albrektsen T....Petersen L.C. (2007)
    295. About the significance or the insignificance of the factor XII C46T polymorphism: a rebuttal. (PubMed id 17883708)1 Girolami A....Lombardi A.M. (2007)
    296. Factor VIIa/tissue factor-dependent gene regulation and pro-coagulant activity: effect of factor VIIa concentration. (PubMed id 17938822)1 Petersen L.C....Sorensen B.B. (2007)
    297. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. (PubMed id 17327234)1 Ghosh S....Rao L.V. (2007)
    298. [Hyperhomocysteinemia--one of the factors underlying thrombotic complications in patients with chronic myeloproliferative diseases] (PubMed id 18220034)1 Sokolova M.A....Kulikov S.M. (2007)
    299. The local phospholipid environment modulates the activation of blood clotting. (PubMed id 17200119)1 Shaw A.W....Morrissey J.H. (2007)
    300. Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. (PubMed id 17890943)1 Franchini M....Lippi G. (2007)
    301. Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface. (PubMed id 17092304)1 Ghosh S....Rao L.V. (2007)
    302. Severe factor VII deficiency caused by a novel point mutation (Arg353Pro) combined with a rare Cys22Arg mutation. (PubMed id 17849063)1 Zhidong W. and Xiaojun H. (2007)
    303. Functional analysis of the genetic variability in the F7 gene promoter. (PubMed id 17292373)1 Sabater-Lleal M....Soria J.M. (2007)
    304. Identification of an inactivating cleavage site for alpha-thrombin on the heavy chain of factor Va. (PubMed id 18000604)1 Erdogan E....Kalafatis M. (2007)
    305. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    306. The emerging role of recombinant activated Factor VII (rFVIIa) in the treatment of blunt traumatic haemorrhage. (PubMed id 16370916)7 Rizoli S.B. and Chughtai T. (2006)
    307. Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange. (PubMed id 16687401)1 Rand K.D....Andersen M.D. (2006)
    308. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    309. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    310. Accurate characterization of the IVS7 repeat polymorphism of FVII gene and identification of three novel allelic forms. (PubMed id 16807660)1 Giansily-Blaizot M....Schved J.F. (2006)
    311. Oriented scanning is the leading mechanism underlying 5' splice site selection in mammals. (PubMed id 16948532)1 Borensztajn K....Amselem S. (2006)
    312. Characterization of a Cys329Gly mutation causing hereditary factor VII deficiency. (PubMed id 16914903)1 Wu Y....Zhu Z. (2006)
    313. Traces of factor VIIa modulate thromboplastin sensitivity to factors V, VII, X, and prothrombin. (PubMed id 16839353)1 Smith S.A....Morrissey J.H. (2006)
    314. Phospholipid surfaces regulate the delivery of substrate to tissue factor:VIIa and the removal of product. (PubMed id 16529959)1 Hathcock J.J....Nemerson Y. (2006)
    315. Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation. (PubMed id 16835245)1 Waters E.K....Morrissey J.H. (2006)
    316. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    317. Factor VIIa binding and internalization in hepatocytes. (PubMed id 16194204)1 Hjortoe G....Rao L.V. (2005)
    318. Molecular mechanism of dysfunctional factor VII assoc iated with the homozygous missense mutation 331Gly to Ser. (PubMed id 15735789)1 Takamiya O. and Kimura S. (2005)
    319. The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex. (PubMed id 15634274)1 Ndonwi M....Bajaj S.P. (2005)
    320. Tissue factor enhances protease-activated receptor-2-mediated factor VIIa cell proliferative properties. (PubMed id 15869604)1 Fan L....Rivard G.E. (2005)
    321. Recombinant factor VIIa (Eptacog Alfa): a review of i ts use in congenital or acquired haemophilia and other congenital bleeding diso rders. (PubMed id 15907148)7 Siddiqui M.A. and Scott L.J. (2005)
    322. A reconsideration of the evidence for structural reorganization in FVII zymogen. (PubMed id 15978118)1 Perera L. and Pedersen L.G. (2005)
    323. Sequential coagulation factor VIIa domain binding to tissue factor. (PubMed id 16236263)1 Osterlund M....Svensson M. (2005)
    324. Association between the factor VII haplotype containing the -402A allele and myocardial infarction in a population of elderly men at high risk for coronary heart disease. (PubMed id 16116695)1 Lindman A.S....Seljeflot I. (2005)
    325. Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity. (PubMed id 15604416)1 Pinotti M....Bernardi F. (2005)
    326. Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity. (PubMed id 16204244)1 Banerjee Y....Kini R.M. (2005)
    327. Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count. (PubMed id 15842358)1 Lisman T....De Groot P.G. (2005)
    328. Factor VII gene polymorphisms are not associated with myocardial infarction in young women. (PubMed id 15842378)1 Peyvandi F....Mannucci P.M. (2005)
    329. Homozygous nonsense mutation (Cys72-->stop) in the human F7 gene: a not life-threatening mutation despite the absence of circulating factor VII. (PubMed id 15634284)1 Chafa O....Tapon-Bretaudiere J. (2005)
    330. Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4. (PubMed id 16510984)1 Kadono S....Kozono T. (2005)
    331. Large enhancement of functional activity of active site-inhibited factor VIIa due to protein dimerization: insights into mechanism of assembly/disassembly from tissue factor. (PubMed id 15835921)1 Stone M.D....Nelsestuen G.L. (2005)
    332. A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo. (PubMed id 15632123)1 Olivero A.G....Kirchhofer D. (2005)
    333. Differential gene expression in activated monocyte-derived macrophages following binding of factor VIIa to tissue factor. (PubMed id 16363246)1 Muth H....Holschermann H. (2005)
    334. An investigation into the human serum 'interacto me'. (PubMed id 15174051)1 Zhou M....Conrads T.P. (2004)
    335. Factor VIIa-mediated tenase function on activated platelets under flow. (PubMed id 15304047)1 Goel M.S. and Diamond S.L. (2004)
    336. FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production. (PubMed id 15016732)1 Versteeg H.H....Peppelenbosch M.P. (2004)
    337. Characterization of mutations causing factor VII deficiency in 61 unrelated Israeli patients. (PubMed id 15456489)1 Fromovich-Amit Y....Seligsohn U. (2004)
    338. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    339. Tissue factor binding of activated factor VII triggers smooth muscle cell proliferation via extracellular signal-regulated kinase activation. (PubMed id 15173027)1 Cirillo P....Chiariello M. (2004)
    340. Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation. (PubMed id 14592825)1 Lisman T....de Groot P.G. (2004)
    341. Prevalence of eight molecular markers associated with thrombotic diseases in six Amerindian tribes and two African groups of Costa Rica. (PubMed id 14689519)4 Herrmann F.H....Schroder W. (2004)
    342. Effect of factor VII -323 Del/Ins polymorphism on the daily variability of factor VIIc and INR in steady anticoagulated patients with acenocoumarol. (PubMed id 15613046)1 Roldan V....Gonzalez-Conejero R. (2004)
    343. [Study of the effect of TF/FVIIa complex on the expre ssion of u-PAR mRNA in human ovarian cancer] (PubMed id 15182581)1 Fang J....Song S.J. (2004)
    344. Herpes simplex virus type 1-encoded glycoprotein C enhances coagulation factor VIIa activity on the virus. (PubMed id 15543320)1 Sutherland M.R....Pryzdial E.L. (2004)
    345. Downregulation of tissue factor by RNA interference in human melanoma LOX-L cells reduces pulmonary metastasis in nude mice. (PubMed id 15386437)1 Wang X....Prydz H. (2004)
    346. A patient homozygous for a Gly354Cys mutation in factor VII that results in severely impaired secretion of the molecule, but not complete deficiency. (PubMed id 14717781)2 Takamiya O. and Hino K. (2004)
    347. The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells. (PubMed id 15213840)1 Wiiger M.T. and Prydz H. (2004)
    348. Molecular characterization of a factor VII deficient patient supports the importance of the second epidermal growth factor-like domain. (PubMed id 15339682)1 D'Andrea G....Margaglione M. (2004)
    349. Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts. (PubMed id 12941034)1 Bachli E.B....McVey J.H. (2003)
    350. Two novel mutations in the human coagulation factor VII promoter. (PubMed id 12888866)1 Kavlie A....Prydz H. (2003)
    351. An all-atom solution-equilibrated model for human extrinsic blood coagulation complex (sTF-VIIa-Xa): a protein-protein docking and molecular dynamics refinement study. (PubMed id 14750502)1 Venkateswarlu D....Pedersen L.G. (2003)
    352. ARP1 interacts with the 5' flanking region of the coagulation factor VII gene. (PubMed id 12871323)1 Carew J.A....Bauer K.A. (2003)
    353. Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site. (PubMed id 12506121)1 Harvey S.B....Nelsestuen G.L. (2003)
    354. Antiapoptotic effect of coagulation factor VIIa. (PubMed id 12738672)1 Sorensen B.B....Petersen L.C. (2003)
    355. Extrahepatic synthesis of factor VII in human atherosclerotic vessels. (PubMed id 12524237)1 Wilcox J.N....Casanova J. (2003)
    356. Regulation of the p21Ras-MAP kinase pathway by factor VIIa. (PubMed id 12871370)1 Versteeg H.H....Peppelenbosch M.P. (2003)
    357. Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor. (PubMed id 12787023)1 Carlsson K....Svensson M. (2003)
    358. Factor VII mutant V154G models a zymogen-like form of factor VIIa. (PubMed id 12358603)1 Toso R....Pollak E.S. (2003)
    359. Inhibitor treatment: state of the art. (PubMed id 12525826)7 Shapiro A. (2003)
    360. Two naturally occurring mutations on FVII gene (S363I-W364C) altering intrinsic catalytic activity. (PubMed id 12428089)1 Peyvandi F....Mannucci P.M. (2002)
    361. Evaluation of potential antigenicity of active-site-inhibited recombinant human FVIIa (FFR-rFVIIa) in an immune-tolerant rat model. (PubMed id 12038786)1 Nicolaisen E.M....Hedner U. (2002)
    362. VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation. (PubMed id 12019261)1 Versteeg H.H....Peppelenbosch M.P. (2002)
    363. A cyclic pentapeptide derived from the second EGF-like domain of Factor VII is an inhibitor of tissue factor dependent coagulation and thrombus formation. (PubMed id 11848442)1 Orning L....Sakariassen K.S. (2002)
    364. The in vitro analysis of the coagulation mechanism of activated factor VII using thrombelastogram. (PubMed id 12428092)1 Kawaguchi C....Yoshioka A. (2002)
    365. Association of factor VII levels with inflammatory parameters in hypercholesterolemic patients. (PubMed id 12208482)1 Porreca E....Iacoviello L. (2002)
    366. Genetic variation in coagulation factors II, V, VII and fatal MI. (PubMed id 11858502)1 Mikkelsson J. and Karhunen P.J. (2002)
    367. Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition. (PubMed id 12135351)1 Petrovan R.J. and Ruf W. (2002)
    368. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    369. Factor VII activity is an independent predictor of cardiovascular mortality in elderly women of a Sicilian population: results of an 11-year follow-up. (PubMed id 11858478)1 Noto D....Averna M.R. (2002)
    370. The inhibitors of the tissue factor:factor VII pathway. (PubMed id 12356487)1 Golino P. (2002)
    371. Factor VIIa induced release of von Willebrand factor from human umbilical vein endothelial cells by a tyrosine kinase dependent pathway. (PubMed id 12083486)1 Brown S.A....Collins P.W. (2002)
    372. Model of a ternary complex between activated factor VII, tissue factor and factor IX. (PubMed id 12152682)1 Chen S.W....Giansily-Blaizot M. (2002)
    373. Response of factor VIII and IX-deficient blood to wild type and high membrane affinity mutant factor VIIa in an in vitro whole blood clotting assay: possible correlation to clinical outcome. (PubMed id 12152685)1 Henderson N....Nelsestuen G.L. (2002)
    374. Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: possible relevance for postprandial lipaemia. (PubMed id 11916081)1 Miller G.J....Miller N.E. (2002)
    375. Associations between homocysteine and coagulation factors--a cross-sectional study in two populations of central Europe. (PubMed id 11562337)1 Kuch B....Hense H.W. (2001)
    376. The factor VII zymogen structure reveals reregistration of beta strands during activation. (PubMed id 11470437)1 Eigenbrot C....Ultsch M.H. (2001)
    377. Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. (PubMed id 11593034)1 Hu Z. and Garen A. (2001)
    378. The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling? (PubMed id 11776298)1 Versteeg H.H....Spek C.A. (2001)
    379. Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity. (PubMed id 11698657)1 Persson E....Olsen O.H. (2001)
    380. Genetic polymorphisms of clotting factors and coronary heart disease. (PubMed id 11926770)4 Donati M.B. and Iacoviello L. (2001)
    381. Candidate genes as potential links between periodontal and cardiovascular diseases. (PubMed id 11887471)4 Kornman K.S. and Duff G.W. (2001)
    382. Residues Y179 and H101 of a hydrophobic patch of factor VII are involved in activation by factor Xa. (PubMed id 11560488)1 Jin J....Straight D.L. (2001)
    383. Inhibitor treatment: state of the art. (PubMed id 11735107)7 Shapiro A. (2001)
    384. Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic act ivity. (PubMed id 10617609)7 Celie P.H....Mertens K. (2000)
    385. Coagulation products and their uses. (PubMed id 10938981)7 Shord S.S. and Lindley C.M. (2000)
    386. A novel missense mutation (C329Q) in factor VII gene. (PubMed id 10877552)1 Wu Y.... Yang W. (2000)
    387. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
    388. Molecular characterization of four novel mutations causing factor VII deficiency. (PubMed id 11920218)1 Tamary H....Seligsohn U. (2000)
    389. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression. (PubMed id 10692465)1 Camerer E....Prydz H. (2000)
    390. Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla). (PubMed id 10544046)1 Kemball-Cook G....Harlos K. (1999)
    391. Factor VIIa/tissue factor generates a form of factor V with unchanged specific activity, resistance to activation by thrombin, and increased sensitivity to activated protein C. (PubMed id 10026263)1 Safa O....Esmon N.L. (1999)
    392. Structure of human factor VIIa and its implications for the triggering of blood coagulation. (PubMed id 10430872)1 Pike A.C....Persson E. (1999)
    393. 'Normal' thrombin generation. (PubMed id 10498586)7 Butenas S....Mann K.G. (1999)
    394. Hereditary deficiency of vitamin-K-dependent coagulat ion factors in Rambouillet sheep. (PubMed id 10192655)7 Baker D.C....Lefkowitz J. (1999)
    395. Association of Blood Clotting Factors I and VII with Phospholipid Monolayers at the Air-Water Interface. (PubMed id 10419671)1 Serfis A.B....Tran N. (1999)
    396. Probing the structural changes in the light chain of human coagulation factor VIIa due to tissue factor association. (PubMed id 10388743)7 Perera L....Pedersen L.G. (1999)
    397. An Arg/Ser substitution in the second epidermal growt h factor-like module of factor IX introduces an O-linked carbohydrate and marke dly impairs activation by factor XIa and factor VIIa/Tissue factor and catalyti c efficiency of factor IXa. (PubMed id 10381508)7 Hertzberg M.S....Hogg P.J. (1999)
    398. Factor VII deficiency caused by a structural variant N57D of the first epidermal growth factor domain. (PubMed id 9414278)2 Leonard B.J....Clarke B.J. (1998)
    399. Two new missense mutations (P134T and A244V) in the coagulation factor VII gene. (PubMed id 9452082)2 Alshinawi C.... Felice A.E. (1998)
    400. Levels of prothrombin activation peptide F1+2 in patients with a bleeding tendency. (PubMed id 9819044)1 Ingerslev J....Negrier C. (1998)
    401. Human neutrophil elastase activates human factor V but inactivates thrombin-activated human factor V. (PubMed id 9242537)1 Samis J.A....Giles A.R. (1997)
    402. Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor. (PubMed id 8647260)1 Persson E. and Nielsen L.S. (1996)
    403. Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity. (PubMed id 8940045)2 Bharadwaj D....Kisiel W. (1996)
    404. Factor VII gene polymorphisms, factor VII:C levels and features of insulin resistance in non-insulin-dependent diabetes mellitus. (PubMed id 8701397)4 Heywood D.M....Grant P.J. (1996)
    405. Kinetics of human factor VII activation. (PubMed id 8639673)1 Butenas S. and Mann K.G. (1996)
    406. Functional characterization of the human factor VII 5'-flanking region. (PubMed id 8576177)1 Pollak E.S....High K.A. (1996)
    407. Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains. (PubMed id 9023546)2 Wang Y.... Spellman M.W. (1996)
    408. Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant. (PubMed id 8743180)4 Humphries S....Miller G. (1996)
    409. Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation. (PubMed id 7814421)1 Kazama Y....Kisiel W. (1995)
    410. Tissue factor pathway inhibitor and the revised theory of coagulation. (PubMed id 7598447)1 Broze G.J. (1995)
    411. The mechanism of inactivation of human factor V and human factor Va by activated protein C. (PubMed id 7989361)1 Kalafatis M.... Mann K.G. (1994)
    412. Association of factor VII genotype with plasma factor VII activity and antigen levels in healthy Indian adults and interaction with triglycerides. (PubMed id 7981180)4 Saha N....Tay J.S. (1994)
    413. Molecular defects in CRM+ factor VII deficiencies: modelling of missense mutations in the catalytic domain of FVII. (PubMed id 8043443)2 Bernardi F.... Marchetti G. (1994)
    414. Regulation of coagulation by a multivalent Kunitz-type inhibitor. (PubMed id 2271516)1 Broze G.J. Jr.... Novotny W.F. (1990)
    415. Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor. (PubMed id 2248955)1 Komiyama Y....Kisiel W. (1990)
    416. Structural genes of coagulation factors VII and X located on 13q34. (PubMed id 3487272)1 Gilgenkrantz S....Pommereuil M. (1986)
    417. Affinity purification of human tissue factor: interac tion of factor VII and tissue factor in detergent micelles. (PubMed id 3455766)1 Guha A....Nemerson Y. (1986)
    418. Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine. (PubMed id 3527261)1 Bach R....Nemerson Y. (1986)
    419. Activation of human factor IX (Christmas factor). (PubMed id 659613)7 di Scipio R.G.... Davie E.W. (1978)
    420. (PubMed id 16003772)4 
    421. Characterisation of a large complex intragenic re-arrangement in the FVII gene (F7) avoiding misdiagnosis in inherited factor VII deficiency. (PubMed id 17614823)9 Giansily-Blaizot M....Claustres M. (2007)
    422. [Coagulation factor VII levels in uremic patients and theirs influence factors] (PubMed id 15631649)9 Fang J....Song S.J. (2004)
    423. Postprandial coagulation factor VII activity: the effect of monounsaturated fatty acids. (PubMed id 9155504)9 Roche H.M. and Gibney M.J. (1997)
    424. Genetic architecture of the F7 gene in a Spanish population: implication for mapping complex diseases and for functional assays. (PubMed id 16650081)9 Sabater-Lleal M....Soria J.M. (2006)
    425. Factor VII deficiency and the FVII mutation database. (PubMed id 11139238)9 McVey J.H....Tuddenham E.G. (2001)
    426. Dietary effects on coagulation factor VII vary across genotypes of the R/Q353 polymorphism in elderly people. (PubMed id 9566996)9 Mennen L.I....Grobbee D.E. (1998)
    427. Occurrence of hereditary leaky red cell syndrome and partial coagulation factor VII deficiency in a Spanish family. (PubMed id 1666726)9 Vives Corrons J.L....Enrich C. (1991)
    428. Establishment of the human coagulation factor VII concentrate European Pharmacopoeia biological reference preparation batch 1. (PubMed id 17270128)9 Dodt J....Buchheit K.H. (2006)
    429. Novel aberrant splicings caused by a splice site mutation (IVS1a+5g>a) in F7 gene. (PubMed id 15968391)9 Ding Q....Wang Z. (2005)
    430. Hemostasis in normotensive and hypertensive men: results of the PROCAM study. The prospective cardiovascular Munster study. (PubMed id 9794731)9 Junker R....Assmann G. (1998)
    431. Activation of coagulation factor VII during alimentary lipemia. (PubMed id 8274479)9 Silveira A....Hamsten A. (1994)
    432. Calibration of human coagulation factor VII concentra te Ph. Eur. BRP batch 2. (PubMed id 20223188)9 Dodt J....Buchheit K.H. (2010)
    433. Rescue of coagulation factor VII function by the U1+5 A snRNA. (PubMed id 19387004)9 Pinotti M....Bernardi F. (2009)
    434. Role of serum prothrombin induced by vitamin K absenc e or antagonist-II in the early detection of hepatocellular carcinoma in patien ts with chronic hepatitis B virus infection. (PubMed id 19391065)9 Yoon Y.J....Kim d.o. .Y. (2009)
    435. The paradoxical association between inherited factor VII deficiency and venous thrombosis. (PubMed id 18282149)9 Marty S....Giansily-Blaizot M. (2008)
    436. [Studies on inherited coagulation factor VII deficiency and tissue factor abnormality in a pedigree] (PubMed id 16792912)9 Ding Q.L....Wang Z.Y. (2006)
    437. Severe FVII deficiency caused by a new point mutation combined with a previously undetected gene deletion. (PubMed id 15667541)9 Hewitt J....MacGillivray R.T. (2005)
    438. The use of activated recombinant coagulation factor VII during haemarthroses and synovectomy in a patient with congenital severe factor V deficiency. (PubMed id 15810919)9 Gonzalez-Boullosa R....Gonzalez-Fajo G. (2005)
    439. Role of the 2 adenine (g.11293_11294insAA) insertion polymorphism in the 3' untranslated region of the factor VII (FVII) gene: molec ular characterization of a patient with severe FVII deficiency. (PubMed id 16173031)9 Peyvandi F....Mannucci P.M. (2005)
    440. Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebo-controlled trial. (PubMed id 15734783)9 Raobaikady R....Grounds R.M. (2005)
    441. Pharmacokinetics of activated recombinant coagulation factor VII (NovoSeven) in children vs. adults with haemophilia A. (PubMed id 15230949)9 Villar A....Giangrande P.L. (2004)
    442. [Double heterozygous mutations of non-canonical splice (IVS1a + 5g > a) and His348Gln caused inherited coagulation factor VII deficiency] (PubMed id 15182580)9 Ding Q.L....Wang Z.Y. (2004)
    443. Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. (PubMed id 15205218)9 Lowe G.D....Packard C.J. (2004)
    444. Fish as bioreactors: transgene expression of human coagulation factor VII in fish embryos. (PubMed id 15129328)9 Hwang G....Maclean N. (2004)
    445. Effects of dietary fat quantity and composition on fasting and postprandial levels of coagulation factor VII and serum choline-containing phospholipids. (PubMed id 12908893)9 Lindman A.S....Pedersen J.I. (2003)
    446. Prevalence of factor VII deficiency and molecular characterization of the F7 gene in Brazilian patients. (PubMed id 12695753)9 Rodrigues D.N....Annichino-Bizzacchi J.M. (2003)
    447. Different effects of oral contraceptives containing levonorgestrel or desogestrel on plasma lipoproteins and coagulation factor VII. (PubMed id 11810082)9 van Rooijen M....Bremme K. (2002)
    448. Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15-base pair insertion in the F7 gene. (PubMed id 11159523)9 Peyvandi F....Bauer K.A. (2001)
    449. Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII. (PubMed id 11459993)9 Sheehan J....Jagadeeswaran P. (2001)
    450. Coagulation factor VII in middle-aged women with and without coronary heart disease. (PubMed id 11372669)9 Eriksson-Berg M....Schenck-Gustafsson K. (2001)
    451. Activated recombinant human coagulation factor VII therapy for intracranial hemorrhage in patients with hemophilia A or B with inhibitors. Results of the novoseven emergency-use program. (PubMed id 10087434)9 Arkin S....Warrier I. (1998)
    452. Chromogenic assays for equine coagulation factors VII, VIII:C, IX, and X, and C1-esterase inhibitor. (PubMed id 9582952)9 Topper M.J. and Prasse K.W. (1998)
    453. Activated and total coagulation factor VII, and fibrinogen in coronary artery disease. (PubMed id 9636964)9 Danielsen R....Morrissey J.H. (1998)
    454. The association of dietary fat and fiber with coagulation factor VII in the elderly: the Rotterdam Study. (PubMed id 9062522)9 Mennen L.I....Grobbee D.E. (1997)
    455. Coagulation factor VII and the risk of coronary heart disease in healthy men. (PubMed id 9301633)9 Junker R....Assmann G. (1997)
    456. Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: differences between older men and women. (PubMed id 9308739)9 Mennen L.I....Grobbee D.E. (1997)
    457. Fibrinogen, coagulation factor VII, tissue plasminogen activator, plasminogen activator inhibitor-1, and lipid as cardiovascular risk factors in chronic hemodialysis and continuous ambulatory peritoneal dialysis patients. (PubMed id 8651250)9 Tomura S....Marumo F. (1996)
    458. Incomplete gamma carboxylation of human coagulation factor VII: differential effects on tissue factor binding and enzymatic activity. (PubMed id 8639446)9 Clarke B.J. and Sridhara S. (1996)
    459. A chromogenic assay for coagulation factor VII: analytical performance characteristics and application in several diseases. (PubMed id 8123879)9 van Wersch J.W. (1993)
    460. A polymorphism in the 5' region of coagulation factor VII gene (F7) caused by an inserted decanucleotide. (PubMed id 8381388)9 Marchetti G....Bernardi F. (1993)
    461. Cerebral ischemia and livedo reticularis in a patient with impairment of coagulation factor VII and free protein S. (PubMed id 1428796)9 Martini A....Muratorio A. (1992)
    462. Moderate red wine consumption and cardiovascular dise ase risk: beyond the 'French paradox'. (PubMed id 20391297)9 Lippi G....Targher G. (2010)
    463. Emergent right lobe adult-to-adult living-donor liver transplantation for high model for end-stage liver disease score severe hepati tis. (PubMed id 20050081)9 Shi-Chun L....Yue Z. (2010)
    464. Haemostatic reference intervals in pregnancy. (PubMed id 20174768)9 Szecsi P.B....Stender S. (2010)
    465. Expression and purification of recombinant human coag ulation factor VII fused to a histidine tag using Gateway technology. (PubMed id 20011642)9 Halabian R....Roudkenar M.H. (2009)
    466. Interrelationship between coagulation factor VII and obesity in diabetes mellitus (type 2). (PubMed id 19329212)9 Karatela R.A. and Sainani G.S. (2009)
    467. Effects of soy consumption on oxidative stress, blood homocysteine, coagulation factors, and phosphorus in peritoneal dialysis patie nts. (PubMed id 19577483)9 Imani H....Hedayati M. (2009)
    468. Liver after hepatocyte transplantation for liver-based metabolic disorders in children. (PubMed id 19364077)9 Quaglia A....Dhawan A. (2008)
    469. [A Jehovah's Witness child with hemophilia B and factor IX inhibitors undergoing scoliosis surgery] (PubMed id 18166748)9 Chau A....Purdy R. (2008)
    470. Factor VII-activating protease in patients with acute deep venous thrombosis. (PubMed id 18394684)9 Sidelmann J.J....Jespersen J. (2008)
    471. CoagMDB: a database analysis of missense mutations within four conserved domains in five vitamin K-dependent coagulation serine proteases using a text-mining tool. (PubMed id 18058827)9 Saunders R.E. and Perkins S.J. (2008)
    472. gamma-Glutamate and beta-hydroxyaspartate in proteins. (PubMed id 18373251)9 Castellino F.J....Zhang L. (2008)
    473. [Emergency right lobe adult-to-adult live-donor liver transplantation for the treatment of acute liver failure following severe hepa titis] (PubMed id 19094619)9 Lu S.C....Li N. (2008)
    474. The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects. (PubMed id 18356686)9 von KAonel R....Fischer J.E. (2008)
    475. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. (PubMed id 18289163)9 Wirtz P.H....von KAonel R. (2008)
    476. Computational study of the putative active form of protein Z (PZa): sequence design and structural modeling. (PubMed id 18493021)9 Chandrasekaran V....Pedersen L.G. (2008)
    477. Diabetes mellitus as a prothrombotic condition. (PubMed id 17645584)9 Grant P.J. (2007)
    478. Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation. (PubMed id 17547839)9 Boden G. and Rao A.K. (2007)
    479. Gentamicin induces sub-therapeutic levels of coagulation factor VII in patients with nonsense mutations. (PubMed id 16879227)9 Pinotti M....Bernardi F. (2006)
    480. Role of coagulation factor VII in pathogenesis of ischemic heart disease. (PubMed id 17357481)9 Hu Y....Wei W. (2006)
    481. Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP). (PubMed id 15654766)9 Nakazawa F....Preissner K.T. (2005)
    482. Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy. (PubMed id 15880050)9 Ruhnke M....Fandrich F. (2005)
    483. Inherited factor VII deficiency: identification of two novel mutations (A191V and T239P) in the catalytic domain. (PubMed id 15907525)9 Borensztajn K....Tapon-BretaudiA"re J. (2005)
    484. Absence of hypercoagulability in acute Kawasaki disease. (PubMed id 15771687)9 Lin M.T....Chiou S.J. (2005)
    485. Nitric oxide and TGF-beta1 inhibit HNF-4alpha function in HEPG2 cells. (PubMed id 15358161)9 Lucas Sd S....Carreno V. (2004)
    486. Hepatocyte transplantation for inherited factor VII deficiency. (PubMed id 15614156)9 Dhawan A....Mieli-Vergani G. (2004)
    487. Effect of modified ultrafiltration on inflammatory mediators, coagulation factors, and other proteins in blood after an extracorporeal circuit. (PubMed id 15046631)9 Fujita M....Maehara T. (2004)
    488. Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. (PubMed id 14977886)9 Kannemeier C....Kanse S.M. (2004)
    489. A case of an inhibitor autoantibody to coagulation fa ctor VII. (PubMed id 12558789)9 Aguilar C....HernA!ndez P. (2003)
    490. [Analysis of an inherited FVII deficiency pedigree caused by homozygosity of Thr359Met] (PubMed id 12697124)9 Chu H.Y....Wang Z.Y. (2003)
    491. Metabolic, inflammatory and haemostatic effects of a low-dose continuous combined HRT in women with type 2 diabetes: potentially safer with respect to vascular risk? (PubMed id 14974908)9 McKenzie J....Sattar N. (2003)
    492. Do oxidized fatty acids activate coagulation factor VII during post-prandial lipemia in women? (PubMed id 12669119)9 Wilson R....Riemersma R.A. (2003)
    493. Weight loss reduces tissue factor in morbidly obese patients. (PubMed id 12917499)9 Kopp C.W....Schernthaner G. (2003)
    494. Cloning and expression of rat coagulation factor VII. (PubMed id 12757778)9 Seetharam S....Feuerstein G. (2003)
    495. Prenatal exclusion of severe factor VII deficiency. (PubMed id 12759632)9 Ariffin H....Lin H.P. (2003)
    496. Oestrogenic repression of human coagulation factor VI I expression mediated through an oestrogen response element sequence motif in t he promoter region. (PubMed id 11929845)9 Di Bitondo R....Winship P.R. (2002)
    497. Structure, function, and activation of coagulation fa ctor VII. (PubMed id 12188897)9 Eigenbrot C. (2002)
    498. Quantitative reverse transcription-PCR measurement of tissue factor mRNA in glioma. (PubMed id 11876468)9 Guan M....Lu Y. (2002)
    499. Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease? (PubMed id 11485106)9 von KAonel R....Dimsdale J.E. (2001)
    500. Low-density lipoprotein apheresis and changes in plasma components. (PubMed id 11724506)9 Kojima S. (2001)
    501. Plasma level of triglyceride-rich lipoprotein remnants is closely associated with the activation of coagulation factor VII in patients with myocardial infarction. (PubMed id 11053611)9 Saigo M....Tei C. (2000)
    502. [Relationship between parameters of hemostasis and manifestations of the metabolic syndrome in men with mild and moderate hypertension] (PubMed id 11076408)9 Ratnikova L.A....Perova N.V. (2000)
    503. Association of coagulation factor VII with the risk of myocardial infarction in the Chinese. (PubMed id 11776135)9 Cai Q....Xu M. (2000)
    504. The impact of postprandial lipemia in accelerating atherothrombosis. (PubMed id 11143761)9 Roche H.M. and Gibney M.J. (2000)
    505. Increased D-dimer levels in twin gestation. (PubMed id 10899347)9 Bar J....Lahav J. (2000)
    506. Genes, coagulation and cardiovascular risk. (PubMed id 10878696)9 Donati M.B....Iacoviello L. (2000)
    507. Activated recombinant human coagulation factor VII (rFVIIa) therapy for abdominal bleeding in patients with inhibitory antibodies to factor VIII. (PubMed id 10679799)9 Liebman H.A....Sham R.L. (2000)
    508. Apparently dominant transmission of a recessive disease: deficiency of factor VII in Iranian Jews. (PubMed id 11202627)9 Tagliabue L....Peyvandi F. (2000)
    509. Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies. (PubMed id 10828024)9 Pinotti M....Bernardi F. (2000)
    510. Atherothrombogenic risk modulation by n-3 fatty acids was not associated with changes in homocysteine in subjects with combined hyperlipidaemia. (PubMed id 10235439)9 Grundt H....Woie L. (1999)
    511. Linear analogues derived from the first EGF-like domain of human blood coagulation factor VII: enhanced inhibition of FVIIa/TF complex activity by backbone modification through aspartimide formation. (PubMed id 10442768)9 Husbyn M....Fischer P.M. (1999)
    512. Genetic effects for plasma factor VII levels independent of and in common with triglycerides. (PubMed id 10102465)9 Hong Y....de Faire U. (1999)
    513. Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor. (PubMed id 9885217)9 BAcguin S....Hemker H.C. (1999)
    514. Evaluation of heliox saturated diving on the basis of selected haemostatic parameters. (PubMed id 10431654)9 OlszaA8ski R. (1998)
    515. Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction. (PubMed id 9420338)9 Iacoviello L....Benedetta Donati M. (1998)
    516. Simultaneous polymerase chain reaction restriction fragment length polymorphism identification of the factor V Leiden allele and the prothrombin 20210A mutation. (PubMed id 9836075)9 Wisotzkey J.D....Monk J.S. (1998)
    517. [Molecular abnormality and deficiency of coagulation factor VII] (PubMed id 9833542)9 Ichinose A. (1998)
    518. Tissue factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII. (PubMed id 9531578)9 Ollivier V....de Prost D. (1998)
    519. Haemostatic risk factors for cardiovascular diseases. (PubMed id 9597424)9 Koenig W. (1998)
    520. Relationships between fasting plasma insulin, anthropometrics, and metabolic parameters in a very old healthy population. Associazione Medica Sabin. (PubMed id 9591743)9 Carantoni M....Fellin R. (1998)
    521. Acquired anti-factor VII (proconvertin) inhibitor: hemorrhage and thrombosis. (PubMed id 9609255)9 Brunod M....Fonteau C. (1998)
    522. Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen. (PubMed id 9286510)9 Zanettini R....Mannucci P.M. (1997)
    523. Haemostatic changes and the oral contraceptive pill. (PubMed id 9488791)9 Norris L.A. and Bonnar J. (1997)
    524. Changes in hemostatic function at times of cyclic variation in occupational stress. (PubMed id 9024741)9 Frimerman A....Keren G. (1997)
    525. Plasma constituents other than low-density lipoprotein adsorbed by dextran-sulfate column. (PubMed id 10225721)9 Kojima S....Yamamoto A. (1997)
    526. Effect of saturated air and nitrox diving on selected parameters of haemostasis. (PubMed id 9591152)9 OlszaA8ski R....Winnicka A. (1997)
    527. Properties of a recombinant chimeric protein in which the gamma-carboxyglutamic acid and helical stack domains of human anticoagulant protein C are replaced by those of human coagulation factor VII. (PubMed id 9184404)9 Geng J.P. and Castellino F.J. (1997)
    528. The Arg353Gln polymorphism reduces the level of coagu lation factor VII. In vivo and in vitro studies. (PubMed id 9409261)9 Hunault M....Bauer K.A. (1997)
    529. Albuminuria is directly associated with increased plasma PAI-1 and factor VII levels in NIDDM patients. (PubMed id 9187410)9 Hirano T....Adachi M. (1997)
    530. Association of tissue factor with a gamma chain homodimer of the IgE receptor type I in cultured human monocytes. (PubMed id 8898969)9 Masuda M....Takahashi H. (1996)
    531. Increased prothrombin fragment 1 + 2 and D-dimer in first-degree relatives of type 2 diabetic patients. Prethrombotic state in relatives of type 2 diabetic patients. (PubMed id 8870813)9 FernA!ndez-CastaA+er M....MartA-nez-Brotons F. (1996)
    532. [The indices of the fibrinolysis, blood coagulation and lipid transport systems in hypertension patients] (PubMed id 9005605)9 Sorokin E.V....Kagan-Ponomarev M.I.a. (1996)
    533. In vivo demonstration in humans that large postprandial triglyceride-rich lipoproteins activate coagulation factor VII through the intrinsic coagulation pathway. (PubMed id 8911271)9 Silveira A....Hamsten A. (1996)
    534. Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly: the Cardiovascular Health Study. Cardiovascular Health Study Investigators. (PubMed id 8651228)9 Cushman M....Tracy R.P. (1996)
    535. Coagulation factor VII, dietary fat and blood lipids: a review. (PubMed id 8902983)9 Mennen L.I....Kluft C. (1996)
    536. Long-term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults. (PubMed id 8883281)9 Johansson J.O....Bengtsson B.A. (1996)
    537. Gemfibrozil reduces thrombin generation in patients with combined hyperlipidaemia, without influencing plasma fibrinogen, fibrin gel structure or coagulation factor VII. (PubMed id 8865525)9 Broijersen A....Hjemdahl P. (1996)
    538. Coagulation factor VII mass and activity in young men with myocardial infarction at a young age. Role of plasma lipoproteins and factor VII genotype. (PubMed id 7749878)9 Moor E....Hamsten A. (1995)
    539. Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists. (PubMed id 7605983)9 Orthner C.L....Fitzgerald L.A. (1995)
    540. The hemostatic profile of equine ovarian follicular fluid. (PubMed id 7701476)9 Yamada M. and Gentry P.A. (1995)
    541. Induction of tissue factor on monocytes by adhesion to endothelial cells. (PubMed id 7536780)9 Lo S.K....Silverstein R.L. (1995)
    542. Factor VII and fibrinogen levels as risk factors for venous thrombosis. A case-control study of plasma levels and DNA polymorphisms--the Leiden Thrombophilia Study (LETS). (PubMed id 7974338)9 Koster T....Vandenbroucke J.P. (1994)
    543. Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. (PubMed id 8086403)9 Muller Y.A.... de Vos A.M. (1994)
    544. Genetic determinants of arterial thrombosis. (PubMed id 7841605)9 Green F. and Humphries S. (1994)
    545. Activated factor X and thrombin formation triggered by tissue factor on endothelial cell matrix in a flow model: effect of the tissue factor pathway inhibitor. (PubMed id 8049429)9 van 't Veer C....Bouma B.N. (1994)
    546. [Coagulation factor VII deficiency in a chronic carrier of the B virus] (PubMed id 8025194)9 Pallares Manrique H....Herrerias Gutierrez J.M. (1994)
    547. Increased cardiovascular risk factors and features of endothelial activation and dysfunction in dialyzed uremic patients. (PubMed id 7996802)9 Gris J.C....Schved J.F. (1994)
    548. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. (PubMed id 7974333)9 KnAPbl P....Vukovich T. (1994)
    549. [Effects of repeated sevoflurane anesthesia on hepati c and renal function in a pediatric patient] (PubMed id 7815713)9 Tanikawa M....Togashi H. (1994)
    550. [Coagulation factor VII--new physiopathological and t herapeutic aspects] (PubMed id 7992413)9 Helleberg C....Ingerslev J. (1994)
    551. Megakaryocyte proplatelet-like process formation in vitro is inhibited by serum prothrombin, a process which is blocked by matrix-bound glycosaminoglycans. (PubMed id 8425575)9 Hunt P....Arakawa T. (1993)
    552. Hematologic correlates of left atrial spontaneous echo contrast and thromboembolism in nonvalvular atrial fibrillation. (PubMed id 8426010)9 Black I.W....Walsh W.F. (1993)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2155 HGNC: 3544 AceView: F7 Ensembl:ENSG00000057593 euGenes: HUgn2155
    ECgene: F7 Kegg: 2155 H-InvDB: F7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F7 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Factor_VII
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/F7
    SeattleSNPshttp://pga.gs.washington.edu/data/f7/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=F7

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    Patent Information for F7 gene:
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