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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

F7 Gene

protein-coding GIFtS: 69
GCID: GC13P113760

coagulation factor VII (serum prothrombin conversion accelerator)

Explore 85 diseases affiliated with
F7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)¹ ²		FVII Coagulation Protein²
Eptacog Alfa² ³		Proconvertin³
SPCA² ³		Proconvertin³
EC 3.4.21.21³ ⁸		Serum Prothrombin Conversion Accelerator³
Coagulation Factor VII²		EC 3.4.21⁸

External Ids:	HGNC: 3544¹	Entrez Gene: 2155²	Ensembl: ENSG00000057593⁷	OMIM: 613878⁵	UniProtKB: P08709³

Export aliases for F7 gene to outside databases

Previous GC identifers: GC13P112370 GC13P108397 GC13P112846 GC13P111708 GC13P112808 GC13P094198

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F7:

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor

circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor

XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain

and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond.

In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by

converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy.

Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by

RefSeq, May 2012)

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709

Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a

zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor

proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by

limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and

calcium

Gene Wiki entry for F7 (Factor VII)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_027140.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the F7 gene promoter:
COUP-TF1 COUP-TF AP-1 COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: F7 promoter sequence

Search SABiosciences Chromatin IP Primers for F7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

F7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F7 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P113760: view genomic region (about GC identifiers)

Start:	113,760,105 bp from pter	End:	113,774,995 bp from pter
Size:	14,891 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709 (See protein sequence)

Recommended Name: Coagulation factor VII precursor

Size: 466 amino acids; 51594 Da

Subunit: Heterodimer of a light chain and a heavy chain linked by a disulfide bond

Subcellular location: Secreted

6/47 PDB 3D structures from and Proteopedia for F7 (see all 47):

1BF9 (3D)

1CVW (3D)

1DAN (3D)

1DVA (3D)

1F7E (3D)

1F7M (3D)

Secondary accessions: B0YJC8 Q14339 Q5JVF1 Q5JVF2 Q9UD52 Q9UD53 Q9UD54

Alternative splicing: 2 isoforms: P08709-1 P08709-2

Explore the universe of human proteins at neXtProt for F7: NX_P08709

Post-translational modifications:

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium¹

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF

domains¹

O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing

complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before

folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence

C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines¹

View neXtProt modification sites for NX_P08709

4/19 DME Specific Peptides for F7 (P08709) (see all 19)

FEGRNCE

CGGTLIN

NGGSCKD

TGIVSWG

F7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000122.1 NP_001254483.1 NP_062562.1

ENSEMBL proteins:

ENSP00000329546 ENSP00000364731 ENSP00000387669 ENSP00000442051

Reactome Protein details: P08709
Human Recombinant Protein Products for F7:

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	Sino Biological Recombinant Protein for F7
	ProSpec Recombinant Protein for F7
	Uscn Proteins for F7

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005796	Golgi lumen	TAS	--
GO:0005886	plasma membrane	TAS	--

F7 for ontologies About GeneDecksing

F7 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for F7 (Coagulation Factor VII)
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Assay Products for F7:

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	GenScript Custom Assay Services for F7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for F7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

F7 for domains About GeneDecksing

5/12 InterPro domains/families (see all 12):

IPR017857 Coagulation_fac_subgr_Gla_dom

IPR001314 Peptidase_S1A

IPR000742 EG-like_dom

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

Graphical View of Domain Structure for InterPro Entry P08709

ProtoNet protein and cluster: P08709

5/7 Blocks protein families (see all 7):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB001438 Type II EGF-like signature

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FA7_HUMAN, P08709

Function: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a

zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor

proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by

limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and

calcium

Catalytic activity: Selective cleavage of Arg- -Ile bond in factor X to form factor Xa

Genatlas biochemistry entry for F7:

coagulation factor VII,vitamin K-dependent (serum protein conversion accelerator),the active form being generated by

the cleavage of Arg152-Ile153 peptide bond and complexing to cofactor F3 of tissue factor

Enzyme Numbers (IUBMB): EC 3.4.21.21¹ ² EC 3.4.21²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IPI	3455766
GO:0004175	endopeptidase activity	--	--
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005102	receptor binding	IEA	--
GO:0005509	calcium ion binding	IEA	--

F7 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for F7:

Decreased Salmonella enterica

Decreased viability of wild-ty

Increased gamma-H2AX phosphory

Metaphase cells

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for F7):

cardiovascular system

homeostasis/metabolism

mortality/aging

no phenotypic analysis

normal

F7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out F7^tm1Pec for F7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for F7

miRNA Products:		OriGene 3'-UTR Clone (see all 2): F7 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	1.00	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	0.73
Gamma-carboxylation of protein precursors	0.82	Warfarin Pathway, Pharmacodynamics	0.67
Removal of aminoterminal propeptides from gamma-carboxylated proteins	0.82	Extrinsic Pathway	0.23

Formation of Fibrin Clot (Clotting Cascade)

	Formation of Fibrin Clot (Clotting Cascade)	1.00			Blood Clotting Cascade	0.36
	Blood Coagulation Signaling Pathways	0.51

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Complement and Coagulation Cascades

0.72

Circadian rhythm - mammal

Circadian Clock

0.41

BMAL1:CLOCK/NPAS2 Activates Circadian Expression

0.23

Asparagine N-linked glycosylation

Post-translational protein modification

0.44

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for F7

Blood Coagulation Signaling Pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F7

	Extrinsic Prothrombin Activation Pathway
	Blood Coagulation Cascade

3 BioSystems Pathways for F7

	Blood Clotting Cascade
	Selenium Pathway
	Complement and Coagulation Cascades

5/13 Reactome Pathways for F7 (see all 13)

	Hemostasis
	Circadian Clock
	Expression of FACTOR VII (F7)
	Extrinsic Pathway
	Removal of aminoterminal propeptides from gamma-carboxylated proteins

1 PharmGKB Pathway for F7

Warfarin Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for F7):

Complement and coagulation cascades

F7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for F7

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/21 Interacting proteins for F7 (P08709^{2, 3} ENSP00000364731⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IKBKG	Q9Y6K9²^,³	MINT-48178 I2D: score=2
F3	P13726³, ENSP00000334145⁴	I2D: score=5 STRING: ENSP00000334145
HPN	P05981³, ENSP00000262626⁴	I2D: score=2 STRING: ENSP00000262626
USP49	Q70CQ1³, ENSP00000297229⁴	I2D: score=2 STRING: ENSP00000297229
GGCX	P38435³, ENSP00000233838⁴	I2D: score=1 STRING: ENSP00000233838

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002690	positive regulation of leukocyte chemotaxis	IDA	17991872
GO:0006508	proteolysis	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0007598	blood coagulation, extrinsic pathway	TAS	--
GO:0007623	circadian rhythm	IEA	--

F7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

F7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for F7
UniProtKB/Swiss-Prot: FA7_HUMAN, P08709

Pharmaceutical: Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding

episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX

2 HMDB Compounds for F7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Menadione	Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)	58-27-5	--

10/12 DrugBank Compounds for F7 (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Coagulation Factor IX	Christmas factor (see all 4)	9001-28-9	target	ligand	10192655 10617609 659613 10938981 10498586 10381508
Coagulation factor VIIa	Coagulation factor VII precursor (see all 5)	9001-25-6	target	--	12525826 16370916 15907148 10388743 11735107
Menadione	2-Methyl-1,4-Naphthalenedione (see all 7)	58-27-5	target	activator	17139284 17016423
2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE	--	--	target	--	10592235
5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)	--	--	target	--	10592235
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA	--	--	target	--	10592235
{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID	--	--	target	--	10592235
(2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID	--	--	target	--	--
2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE)	--	--	target	--	--
2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE)	--	--	target	--	--

10/15 Novoseek chemical compound relationships for F7 gene (see all 15) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	70.8	46	8651250 (2), 9636964 (2), 19577483 (2), 2335101 (1) (see all 40)
gamma-carboxyglutamic acid	55.1	3	1633870 (1), 18373251 (1), 9184404 (1)
warfarin	38.9	1	2377284 (1)
serine	36.6	8	1970743 (1), 11876468 (1), 18058827 (1), 8639446 (1) (see all 8)
cholesterol	34.2	5	8386689 (1), 17059418 (1), 1793443 (1)
kininogen	26.6	1	10225721 (1)
levonorgestrel	20.1	1	11810082 (1)
glucose	13.8	5	9591743 (1), 2055073 (1), 12917499 (1), 17675296 (1)
lipid	4.79	5	9005605 (1), 8651250 (1), 14766762 (1), 1753430 (1)
gentamicin	2.31	1	16879227 (1)

Search CenterWatch for drugs/clinical trials and news about F7 / FA7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for F7 gene (3 alternative transcripts):

NM_000131.4 NM_001267554.1 NM_019616.3

Unigene Cluster for F7:

Coagulation factor VII (serum prothrombin conversion accelerator)

Hs.36989 [show with all ESTs]

Unigene Representative Sequence: NM_000131

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000346342(uc010agp.1) ENST00000375581(uc001vsv.3 uc001vsw.3 uc010tjt.2)

ENST00000444337 ENST00000479674 ENST00000473085 ENST00000541084

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		Sirion Biotech Custom design and validation of potent shRNA sequences against F7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F7 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for F7 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): F7 (NM_000131)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F7

Additional cDNA sequence:

AK298404.1 AK310779.1 AK311565.1 AK311682.1 AY423856.1 BC130468.1 EF421855.1 EU557239.1

M13232.1 NR_051961.1

2 DOTS entries:

DT.107779 DT.92417225

21 AceView cDNA sequences:

AI076552 AL531727 CB156039 AI076550 NM_000131 AA701917 BV199077 NM_019616

BX095482 AA256666 AA256665 AY423856 M78203 M13232 AA677801 AU099140

AL531726 AA133523 AI247880 AA002224 BE939170

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for F7 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:																			-
SP2:							-												-
SP3:							-		-				-						-
SP4:																			-		-
SP5:

ECgene alternative splicing isoforms for F7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

F7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See F7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for F7

SOURCE GeneReport for Unigene cluster: Hs.36989

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709

Tissue specificity: Plasma

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for F7 gene from 12 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	F7¹	coagulation factor VII (serum prothrombin conversion more	98.72(n) 98.65(a)		744785 XM_001149885.2 XP_001149885.2
mouse (Mus musculus)	Mammalia	F7^{1 , 5}	coagulation factor VII^{1, 5}	76.96(n)¹ 71.62(a)¹		8 (5.73 cM)⁵ 14068¹ NM_010172.3¹ NP_034302.2¹ 13026034⁵
rat (Rattus norvegicus)	Mammalia	F7¹	coagulation factor VII (serum prothrombin conversion more	76.7(n) 69.89(a)		260320 NM_152846.1 NP_690059.1
cow (Bos taurus)	Mammalia	F7¹	coagulation factor VII (serum prothrombin conversion more	78.06(n) 71.36(a)		617960 NM_001034806.1 NP_001029978.1
dog (Canis familiaris)	Mammalia	F7¹	coagulation factor VII (serum prothrombin conversion more	81.02(n) 76.08(a)		607661 NM_001048033.1 NP_001041498.1
oppossum (Monodelphis domestica)	Mammalia	F7⁶	--	64(a)	1 ↔ 1	7(77901032-77934447)
chicken (Gallus gallus)	Aves	F7¹	coagulation factor VII (serum prothrombin conversion more	59.68(n) 57.11(a)		395086 NM_204442.1 NP_989773.1
lizard (Anolis carolinensis)	Reptilia	F7⁶	--	47(a)	1 ↔ 1	3(105930694-105943088)
zebrafish (Danio rerio)	Actinopterygii	AY040345.1²	--	72.42(n)		114423 AY040345.1
sea urchin (Strongylocentrotus purpuratus)	Echinoidea	-- -- (see all 3)	--	27(a) 16(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	scaffold_1399(139315-141367) scaffold_436(277737-303485)
fruit fly (Drosophila melanogaster)	Insecta	CG9294³	serine-type endopeptidase	36(a) (best of 2)		58A3 --
sea anemone (Nematostella vectensis)	Anthozoa	NVBF-1⁶ -- (see all 7)	--	36(a) 30(a) (see all 7)	possible ortholog possible ortholog (see all 7)	scaffold_465(38140-44641) scaffold_40(1198001-1205086)

Species with no ortholog for F7

ENSEMBL Gene Tree for F7 (if available)
TreeFam Gene Tree for F7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for F7 gene

PROZ² PAMR1² C1S² C1R² C1RL² F9² MASP1² F10²

F2² HPR² HP² PROC² MASP2²

18/56 SIMAP similar genes for F7 using alignment to 6 protein entries: FA7_HUMAN (see all proteins) (see all similar genes):

F2 F9 PROC1 DKFZp586F0824 F12 FBN2

GAS6 MATN2 SNED1 HP F9 p22 factor IX F9

F10 PROC TRY8 PRSS1 PRSS45 GZMK

F7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs36209567^1,2	C	pathogenic	113772982(+)	`CACGGC/TCCTGG`	7	A V	nc-transcript-variantmis¹		3		NS NA	4440
rs121964926^1,2	C,F	probable-pathogenic	113773012(+)	`GCCCCG/AGCTGA`	7	/Q /R	nc-transcript-variantmis¹		1		NA	4352
rs121964938^1,2	C	probable-pathogenic	113773084(+)	`CATGTC/G/TCTGTG`	11	S C F	nc-transcript-variantmis¹		0	--	--	--	--
rs121964936^1,2	C	probable-pathogenic	113773145(+)	`CCACAG/TGCCAC`	7	Q H	nc-transcript-variantmis¹		0	--	--	--	--
rs6046^1,2	C,F,H	other	113773159(-)	`TGCCCA/C/G/T GGTAG`	15	Q P R L	mis¹ ese³		42		MN NA NS EA WA EU	10951
rs3093260^1,2	C,F,H	--	94213913(+)	`TTGTCC/TGAGTG`	1	--	us2k¹		7		NS EA	550
rs77662646^1,2		--	94214024(+)	`GCCATG/CGTCAT`	1	--	us2k¹		2		CSA WA	120
rs78942558^1,2	C	--	94214036(+)	`GACAGA/CAAAGC`	1	--	us2k¹		0	--	--	--	--
rs3093233^1,2	C,F,A,H	--	113758130(+)	`CTGCTA/GCTCCG`	4	--	us2k¹		16		NS EA NA WA CSA	2787
rs180904317^1,2		--	113758149(+)	`GGTCCA/TGCCCC`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for F7 (113760105 - 113774995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for F7
4 CNVs: 9723 4819 66566 66565
5 Indels: 87066 76519 11703 76520 43041
Human Gene Mutation Database (HGMD): F7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

F7 for disorders About GeneDecksing

OMIM gene information: 613878 OMIM disorders: --

UniProtKB/Swiss-Prot: FA7_HUMAN, P08709

Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. A hemorrhagic disease with variable

presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or

repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or

hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very

low factor VII levels

20/85 diseases for F7 (see all 85): About MalaCards

carotid intimal medial thickness factor vii deficiency vitamin k deficiency hemorrhagic disease dubin-johnson syndrome

von willebrand's disease factor xi deficiency disseminated intravascular coagulation factor viii deficiency

factor v deficiency glanzmann's thrombasthenia factor x deficiency pre-eclampsia

myocardial infarction growth hormone deficiency acute myocardial infarction coronary heart disease

protein c deficiency hemophilia amyotrophic lateral sclerosis carotid stenosis

15 diseases from the University of Copenhagen DISEASES database for F7:

Factor VII deficiency Heart disease Disseminated intravascular coagulation Factor XI deficiency

Glanzmann's thrombasthenia Hemophilia B Von Willebrand's disease Cerebrovascular accident

Vitamin K deficiency hemorrhagic disease Atherosclerosis Factor X deficiency Liver disease

Thrombocytopenia Factor VIII deficiency Diabetes mellitus

10/31 Novoseek disease relationships for F7 gene (see all 31) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
factor vii deficiency	91	16	1666726 (3), 8844208 (2), 16792912 (1), 12695753 (1) (see all 13)
coronary heart disease	52.6	8	11372669 (2), 17581323 (1), 9301633 (1), 15081566 (1) (see all 7)
coagulopathy	52	2	11202627 (1), 15734783 (1)
thrombosis	45.2	10	18282149 (2), 8086403 (1), 9301633 (1), 11143761 (1) (see all 9)
myocardial infarction	42.1	11	12935410 (1), 11578716 (1), 11776135 (1), 17059418 (1) (see all 11)
cardiovascular diseases	41.6	7	9187410 (1), 9308739 (1), 10828024 (1), 17059418 (1) (see all 7)
hemophilia a	37.3	2	10087434 (2)
thrombophilia	35.8	3	15771687 (1), 16292673 (1)
von willebrand disease	27.8	1	9885217 (1)
intracranial hemorrhages	24.7	1	10087434 (1)

Genatlas disease: F7

hypoproconvertinemia

Genetic Association Database (GAD): F7
Human Genome Epidemiology (HuGE) Navigator: F7 (156 documents)

Export disorders for F7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for F7 gene, integrated from 9 sources (see all 560):
(articles sorted by number of sources associating them with F7)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2- Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z. (PubMed id 2511201)^{1, 2, 3} Nishimura H.... Iwanaga S. (1989)
Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells. (PubMed id 3264725)^{1, 2, 3} Thim L.... Hedner U. (1988)
Human F7 sequence is split into three deep clades that are related to FVII plasma levels. (PubMed id 16292673)^{1, 2, 9} Sabater-Lleal M.... Calafell F. (2006)
Molecular analysis of the genotype-phenotype relationship in factor VII deficiency. (PubMed id 11129332)^{1, 2, 9} Millar D.S.... Cooper D.N. (2000)
Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease. (PubMed id 15081566)^{1, 4, 9} Lindman A.S....Seljeflot I. (2004)
Mutation pattern in clinically asymptomatic coagulation factor VII deficiency. (PubMed id 8844208)^{1, 2, 9} Bernardi F.... Marchetti G. (1996)
Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII. (PubMed id 8242057)^{1, 2, 9} Takamiya O.... McVey J.H. (1993)
Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise training. (PubMed id 14766762)^{1, 4, 9} Ghiu I.A....Hagberg J.M. (2004)
Polymorphisms of the coagulation factor VII gene and its plasma levels in relation to acute cerebral infarction differences in allelic frequencies between Chinese Han and European populations. (PubMed id 14733777)^{1, 4, 9} Kang W.Y....Wang Z.Y. (2004)
The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene. (PubMed id 15175795)^{1, 4, 9} Lindman A.S....Seljeflot I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2155	HGNC: 3544	AceView: F7	Ensembl:ENSG00000057593	euGenes: HUgn2155
ECgene: F7	Kegg: 2155	H-InvDB: F7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for F7	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Factor_VII
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/F7
SeattleSNPs	http://pga.gs.washington.edu/data/f7/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=F7

Intellectual Property for F7 gene
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Patent Information for F7 gene:
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GeneCards and IP:
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coagulation factor VII (serum prothrombin conversion accelerator)

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F7 Gene

coagulation factor VII (serum prothrombin conversion accelerator)

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