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Aliases for F7 Gene

Aliases for F7 Gene

  • Coagulation Factor VII (Serum Prothrombin Conversion Accelerator) 2 3
  • Eptacog Alfa 2 3 4
  • FVII Coagulation Protein 2 3
  • Proconvertin 3 4
  • EC 4 63
  • SPCA 3 4
  • Serum Prothrombin Conversion Accelerator 4
  • Coagulation Factor VII 3
  • Factor VII 2
  • EC 3.4.21 63

External Ids for F7 Gene

Previous GeneCards Identifiers for F7 Gene

  • GC13P112370
  • GC13P108397
  • GC13P112846
  • GC13P111708
  • GC13P112808
  • GC13P113760
  • GC13P094198

Summaries for F7 Gene

Entrez Gene Summary for F7 Gene

  • This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for F7 Gene

F7 (Coagulation Factor VII (Serum Prothrombin Conversion Accelerator)) is a Protein Coding gene. Diseases associated with F7 include factor vii deficiency and proconvertin deficiency, congenital. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for F7 Gene

  • Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium

Gene Wiki entry for F7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F7 Gene

Genomics for F7 Gene

Regulatory Elements for F7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for F7 Gene

113,105,788 bp from pter
113,120,681 bp from pter
14,894 bases
Plus strand

Genomic View for F7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F7 Gene

Proteins for F7 Gene

  • Protein details for F7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coagulation factor VII
    Protein Accession:
    Secondary Accessions:
    • B0YJC8
    • Q14339
    • Q5JVF1
    • Q5JVF2
    • Q9UD52
    • Q9UD53
    • Q9UD54

    Protein attributes for F7 Gene

    466 amino acids
    Molecular mass:
    51594 Da
    Quaternary structure:
    • Heterodimer of a light chain and a heavy chain linked by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for F7 Gene

    Alternative splice isoforms for F7 Gene


neXtProt entry for F7 Gene

Proteomics data for F7 Gene at MOPED

Post-translational modifications for F7 Gene

  • Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro
  • O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines.
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium
  • Glycosylation at Ser112, Ser120, Asn205, and Asn382
  • Modification sites at PhosphoSitePlus

Other Protein References for F7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for F7 (Coagulation Factor VII)

Domains for F7 Gene

Suggested Antigen Peptide Sequences for F7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EGF-like domains.
  • Belongs to the peptidase S1 family.
  • Contains 2 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with F7: view

No data available for Gene Families for F7 Gene

Function for F7 Gene

Molecular function for F7 Gene

GENATLAS Biochemistry:
coagulation factor VII,vitamin K-dependent (serum protein conversion accelerator),the active form being generated by the cleavage of Arg152-Ile153 peptide bond and complexing to cofactor F3 of tissue factor
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Ile bond in factor X to form factor Xa
UniProtKB/Swiss-Prot Function:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium

Enzyme Numbers (IUBMB) for F7 Gene

Gene Ontology (GO) - Molecular Function for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 3455766
GO:0003824 catalytic activity --
GO:0004175 endopeptidase activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with F7: view
genes like me logo Genes that share phenotypes with F7: view

Animal Models for F7 Gene

MGI Knock Outs for F7:
  • F7 tm1Pec

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for F7 Gene

Localization for F7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F7 Gene


Subcellular locations from

Jensen Localization Image for F7 Gene COMPARTMENTS Subcellular localization image for F7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F7: view

Pathways for F7 Gene

genes like me logo Genes that share pathways with F7: view

Gene Ontology (GO) - Biological Process for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002690 positive regulation of leukocyte chemotaxis IDA 17991872
GO:0006508 proteolysis TAS --
GO:0007596 blood coagulation TAS --
GO:0007598 blood coagulation, extrinsic pathway TAS --
GO:0007623 circadian rhythm TAS --
genes like me logo Genes that share ontologies with F7: view

Drugs for F7 Gene

(12) Drugbank Compounds for F7 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 2-Methyl-1,4-Naphthalenedione
58-27-5 4055 Target activator approved, nutraceutical
Coagulation Factor IX
  • Christmas factor
9001-28-9 Target ligand approved
Coagulation factor VIIa
  • Coagulation factor VII precursor
9001-25-6 Target approved
6852220 Target experimental
15942655 Target experimental


Pharmaceutical: Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX

(4) ApexBio Compounds for F7 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor [865479-71-6]
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct [211914-51-1]
CORM-3 Exhibits anti-inflammatory/cardioprotective effects [475473-26-8]
Rivaroxaban Factor Xa inhibitor [366789-02-8]

(2) HMDB Compounds for F7 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • 2-Methyl-1,4-naftochinon

(15) Novoseek inferred chemical compound relationships for F7 Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 70.8 43
gamma-carboxyglutamic acid 55.1 3
warfarin 38.9 1
serine 36.6 8
cholesterol 34.2 3
genes like me logo Genes that share compounds with F7: view

Compound Products

Transcripts for F7 Gene

Unigene Clusters for F7 Gene

Coagulation factor VII (serum prothrombin conversion accelerator):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for F7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F7 Gene

mRNA expression in normal human tissues for F7 Gene

mRNA differential expression in normal tissues according to GTEx for F7 Gene

This gene is overexpressed in Liver (46.1).

Protein differential expression in normal tissues for F7 Gene

This gene is overexpressed in Plasma (33.9) and Serum (28.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for F7 Gene

SOURCE GeneReport for Unigene cluster for F7 Gene Hs.36989

mRNA Expression by UniProt/SwissProt for F7 Gene

Tissue specificity: Plasma
genes like me logo Genes that share expressions with F7: view

Expression partners for F7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for F7 Gene

Orthologs for F7 Gene

This gene was present in the common ancestor of animals.

Orthologs for F7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia F7 35
  • 77.36 (n)
  • 70.02 (a)
F7 36
  • 69 (a)
(Canis familiaris)
Mammalia F7 35
  • 81.35 (n)
  • 75.99 (a)
F7 36
  • 76 (a)
(Mus musculus)
Mammalia F7 35
  • 77.25 (n)
  • 71.33 (a)
F7 16
F7 36
  • 70 (a)
(Pan troglodytes)
Mammalia F7 35
  • 98.72 (n)
  • 98.65 (a)
F7 36
  • 98 (a)
(Rattus norvegicus)
Mammalia F7 35
  • 77.3 (n)
  • 70.5 (a)
(Monodelphis domestica)
Mammalia F7 36
  • 64 (a)
(Gallus gallus)
Aves F7 35
  • 59.78 (n)
  • 57.71 (a)
F7 36
  • 57 (a)
(Anolis carolinensis)
Reptilia F7 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia f7 35
  • 57.98 (n)
  • 57.07 (a)
(Danio rerio)
Actinopterygii -- 35
zgc:163025 35
  • 57.51 (n)
  • 49.37 (a)
F7 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13744 37
  • 35 (a)
CG9294 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for F7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F7 Gene

Gene Tree for F7 (if available)
Gene Tree for F7 (if available)

Paralogs for F7 Gene

Paralogs for F7 Gene

genes like me logo Genes that share paralogs with F7: view

Variants for F7 Gene

Sequence variations from dbSNP and Humsavar for F7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs139666622 -- 113,105,036(+) AAAAA(A/T)AAAAA upstream-variant-2KB
rs139474305 -- 113,119,418(+) TCTGC(C/T)TTCAT utr-variant-3-prime, nc-transcript-variant
rs139426699 -- 113,120,535(+) ATTGG(-/CACT)CACAG utr-variant-3-prime, nc-transcript-variant
rs139372641 -- 113,118,616(+) TCGTG(C/T)GCTTC reference, missense, nc-transcript-variant
rs139309572 -- 113,116,846(+) GCAAG(A/G)TGTGC missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for F7 Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
dgv1798n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
nsv901053 CNV Loss 21882294
dgv1800n71 CNV Loss 21882294
nsv832724 CNV Loss 17160897
nsv818996 CNV Gain 17921354
esv22720 CNV Loss 19812545
esv1703089 CNV Insertion 17803354
esv2748244 CNV Deletion 23290073
esv1400714 CNV Insertion 17803354
esv2748245 CNV Deletion 23290073
esv2748246 CNV Deletion 23290073
esv1083485 CNV Insertion 17803354
esv2748247 CNV Deletion 23290073
esv2748248 CNV Deletion 23290073
esv2748249 CNV Deletion 23290073
esv2748250 CNV Deletion 23290073
esv5028 CNV Deletion 18987735
dgv277e201 CNV Deletion 23290073
dgv278e201 CNV Deletion 23290073
esv2748258 CNV Deletion 23290073
esv2748259 CNV Deletion 23290073
esv2748260 CNV Deletion 23290073
nsv64704 CNV Loss 16902084
nsv901060 CNV Gain 21882294
dgv1801n71 CNV Gain 21882294

Relevant External Links for F7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F7 Gene

Disorders for F7 Gene

(2) OMIM Diseases for F7 Gene (613878)


  • Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. {ECO:0000269 PubMed:10862079, ECO:0000269 PubMed:11091194, ECO:0000269 PubMed:11129332, ECO:0000269 PubMed:12472587, ECO:0000269 PubMed:14717781, ECO:0000269 PubMed:1634227, ECO:0000269 PubMed:18976247, ECO:0000269 PubMed:19432927, ECO:0000269 PubMed:19751712, ECO:0000269 PubMed:2070047, ECO:0000269 PubMed:21206266, ECO:0000269 PubMed:21372693, ECO:0000269 PubMed:7974346, ECO:0000269 PubMed:7981691, ECO:0000269 PubMed:8043443, ECO:0000269 PubMed:8204879, ECO:0000269 PubMed:8364544, ECO:0000269 PubMed:8652821, ECO:0000269 PubMed:8844208, ECO:0000269 PubMed:8883260, ECO:0000269 PubMed:8940045, ECO:0000269 PubMed:9414278, ECO:0000269 PubMed:9452082, ECO:0000269 PubMed:9576180}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(31) Novoseek inferred disease relationships for F7 Gene

Disease -log(P) Hits PubMed IDs
factor vii deficiency 91 16
coronary heart disease 52.6 8
coagulopathy 52 2
thrombosis 45.2 10
myocardial infarction 42.1 11

Genatlas disease for F7 Gene


Relevant External Links for F7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with F7: view

Publications for F7 Gene

  1. Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7). (PMID: 1634227) Marchetti G. … Bernardi F. (Hum. Genet. 1992) 3 4 23
  2. Topologically equivalent mutations causing dysfunctional coagulation factors VII (294Ala-->Val) and X (334Ser-->Pro). (PMID: 7981691) Bernardi F. … Marchetti G. (Hum. Mol. Genet. 1994) 3 4 23
  3. Mutation pattern in clinically asymptomatic coagulation factor VII deficiency. (PMID: 8844208) Bernardi F. … Marchetti G. (Hum. Mutat. 1996) 3 4 23
  4. Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII. (PMID: 8242057) Takamiya O. … McVey J.H. (Hum. Mol. Genet. 1993) 3 4 23
  5. Molecular analysis of the genotype-phenotype relationship in factor VII deficiency. (PMID: 11129332) Millar D.S. … Cooper D.N. (Hum. Genet. 2000) 3 4 23

Products for F7 Gene

Sources for F7 Gene

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