Free for academic non-profit institutions. Other users need a Commercial license

Aliases for F7 Gene

Aliases for F7 Gene

  • Coagulation Factor VII 2 3 5
  • Eptacog Alfa 2 3 4
  • Coagulation Factor VII (Serum Prothrombin Conversion Accelerator) 2 3
  • FVII Coagulation Protein 2 3
  • Proconvertin 3 4
  • EC 4 61
  • SPCA 3 4
  • Serum Prothrombin Conversion Accelerator 4
  • Factor VII 2
  • EC 3.4.21 61

External Ids for F7 Gene

Previous GeneCards Identifiers for F7 Gene

  • GC13P112370
  • GC13P108397
  • GC13P112846
  • GC13P111708
  • GC13P112808
  • GC13P113760
  • GC13P094198

Summaries for F7 Gene

Entrez Gene Summary for F7 Gene

  • This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

GeneCards Summary for F7 Gene

F7 (Coagulation Factor VII) is a Protein Coding gene. Diseases associated with F7 include Factor Vii Deficiency and Myocardial Infarction. Among its related pathways are Collagen biosynthesis and modifying enzymes and BMAL1-CLOCK,NPAS2 activates circadian gene expression. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is F10.

UniProtKB/Swiss-Prot for F7 Gene

  • Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Gene Wiki entry for F7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F7 Gene

Genomics for F7 Gene

Regulatory Elements for F7 Gene

Enhancers for F7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F113078 0.5 ENCODE 17.3 -26.8 -26812 0.9 SCRT1 POLR2A MNT ZNF2 F7 F10 F10-AS1 KARSP2 PROZ PIR52168 GC13M113086 GC13M113087
GH13F113083 0.7 ENCODE 13.6 -22.0 -21990 1.5 TBP CTCF MXI1 KLF1 PKNOX1 MAX RFX5 ZNF366 SCRT2 SMC3 MCF2L F7 PROZ MCF2L-AS1 GC13M113086 GC13M113087 PIR52168
GH13F113138 0.6 ENCODE 11.5 +33.5 33537 0.8 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 NFYC F7 GRTP1-AS1 GRTP1 F10 KARSP2 LOC102724474
GH13F113137 0.4 ENCODE 11.5 +32.3 32263 0.9 ATF3 F7 GRTP1-AS1 GRTP1 KARSP2 LOC102724474
GH13F113105 0.7 Ensembl ENCODE 11.3 0.0 -19 1.3 PKNOX1 MLX ARID4B GLI4 DMAP1 ZNF2 ZNF48 YY1 GLIS2 MIER2 F7 MCF2L F10 GC13P113090 GC13P113091
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around F7 on UCSC Golden Path with GeneCards custom track

Genomic Location for F7 Gene

113,105,788 bp from pter
113,120,681 bp from pter
14,894 bases
Plus strand

Genomic View for F7 Gene

Genes around F7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F7 Gene

Proteins for F7 Gene

  • Protein details for F7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coagulation factor VII
    Protein Accession:
    Secondary Accessions:
    • B0YJC8
    • Q14339
    • Q5JVF1
    • Q5JVF2
    • Q9UD52
    • Q9UD53
    • Q9UD54

    Protein attributes for F7 Gene

    466 amino acids
    Molecular mass:
    51594 Da
    Quaternary structure:
    • Heterodimer of a light chain and a heavy chain linked by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for F7 Gene

    Alternative splice isoforms for F7 Gene


neXtProt entry for F7 Gene

Selected DME Specific Peptides for F7 Gene


Post-translational modifications for F7 Gene

  • Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.
  • O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines.
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
  • Glycosylation at Ser 112, Ser 120, Asn 205, and Asn 382
  • Modification sites at PhosphoSitePlus

Protein Products

Domains & Families for F7 Gene

Gene Families for F7 Gene

Suggested Antigen Peptide Sequences for F7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EGF-like domains.
  • Belongs to the peptidase S1 family.
  • Contains 2 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with F7: view

Function for F7 Gene

Molecular function for F7 Gene

GENATLAS Biochemistry:
coagulation factor VII,vitamin K-dependent (serum protein conversion accelerator),the active form being generated by the cleavage of Arg152-Ile153 peptide bond and complexing to cofactor F3 of tissue factor
UniProtKB/Swiss-Prot CatalyticActivity:
Selective cleavage of Arg- -Ile bond in factor X to form factor Xa.
UniProtKB/Swiss-Prot Function:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Enzyme Numbers (IUBMB) for F7 Gene

Gene Ontology (GO) - Molecular Function for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 3455766
GO:0004175 endopeptidase activity IEA --
GO:0004252 contributes_to serine-type endopeptidase activity IEA,IDA 24998411
GO:0005102 receptor binding IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with F7: view
genes like me logo Genes that share phenotypes with F7: view

Human Phenotype Ontology for F7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for F7 Gene

MGI Knock Outs for F7:
  • F7 tm1Pec
  • F7 tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for F7

Inhibitory RNA Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for F7 Gene

Localization for F7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F7 Gene


Subcellular locations from

Jensen Localization Image for F7 Gene COMPARTMENTS Subcellular localization image for F7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F7: view

Pathways & Interactions for F7 Gene

genes like me logo Genes that share pathways with F7: view

Gene Ontology (GO) - Biological Process for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002690 positive regulation of leukocyte chemotaxis IDA 17991872
GO:0006465 signal peptide processing TAS --
GO:0006508 proteolysis IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
genes like me logo Genes that share ontologies with F7: view

No data available for SIGNOR curated interactions for F7 Gene

Drugs & Compounds for F7 Gene

(25) Drugs for F7 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra Target, activator 230
Coagulation Factor IX (Recombinant) Approved Pharma Target, ligand 0
Coagulation factor VIIa Recombinant Human Approved Pharma Target 0
Rivaroxaban Approved Pharma Factor Xa inhibitor 244

(7) Additional Compounds for F7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for F7 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor 865479-71-6
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
CORM-3 Exhibits anti-inflammatory/cardioprotective effects 475473-26-8
Rivaroxaban Factor Xa inhibitor 366789-02-8
genes like me logo Genes that share compounds with F7: view

Transcripts for F7 Gene

Unigene Clusters for F7 Gene

Coagulation factor VII (serum prothrombin conversion accelerator):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for F7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for F7 Gene

mRNA differential expression in normal tissues according to GTEx for F7 Gene

This gene is overexpressed in Liver (x46.1).

Protein differential expression in normal tissues from HIPED for F7 Gene

This gene is overexpressed in Plasma (33.9) and Serum (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for F7 Gene

Protein tissue co-expression partners for F7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of F7 Gene:


SOURCE GeneReport for Unigene cluster for F7 Gene:


mRNA Expression by UniProt/SwissProt for F7 Gene:

Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with F7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for F7 Gene

Orthologs for F7 Gene

This gene was present in the common ancestor of animals.

Orthologs for F7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F7 34 35
  • 98.72 (n)
(Canis familiaris)
Mammalia F7 34 35
  • 81.35 (n)
(Bos Taurus)
Mammalia F7 34 35
  • 77.36 (n)
(Rattus norvegicus)
Mammalia F7 34
  • 77.3 (n)
(Mus musculus)
Mammalia F7 34 16 35
  • 77.25 (n)
(Monodelphis domestica)
Mammalia F7 35
  • 64 (a)
(Gallus gallus)
Aves F7 34 35
  • 59.78 (n)
(Anolis carolinensis)
Reptilia F7 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia f7 34
  • 57.98 (n)
(Danio rerio)
Actinopterygii zgc:163025 34
  • 57.51 (n)
F7 35
  • 45 (a)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG9294 36
  • 36 (a)
CG13744 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
Species where no ortholog for F7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F7 Gene

Gene Tree for F7 (if available)
Gene Tree for F7 (if available)

Paralogs for F7 Gene

Variants for F7 Gene

Sequence variations from dbSNP and Humsavar for F7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs121964926 Factor VII deficiency (FA7D) [MIM:227500] 113,118,698(+) GCCCC(A/G)GCTGA nc-transcript-variant, reference, missense
rs121964927 Factor VII deficiency (FA7D) [MIM:227500], Pathogenic 113,118,716(+) GGACT(G/T)CCTGC nc-transcript-variant, reference, missense
rs121964928 Factor VII deficiency (FA7D) [MIM:227500] 113,117,504(+) GTTGT(A/C/G)TGGGG nc-transcript-variant, reference, missense
rs121964929 Factor VII deficiency (FA7D) [MIM:227500] 113,118,527(+) GCTCC(A/G)CCTGC nc-transcript-variant, reference, missense
rs121964930 Factor VII deficiency (FA7D) [MIM:227500] 113,118,863(+) CCTGA(C/T)GGGCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for F7 Gene

Variant ID Type Subtype PubMed ID
dgv1129e59 CNV duplication 20981092
dgv250e201 CNV deletion 23290073
dgv251e201 CNV deletion 23290073
dgv3426n54 CNV gain 21841781
dgv3427n54 CNV loss 21841781
dgv3428n54 CNV loss 21841781
dgv3429n54 CNV gain 21841781
esv1083485 CNV insertion 17803354
esv1400714 CNV insertion 17803354
esv1703089 CNV insertion 17803354
esv22720 CNV loss 19812545
esv2748244 CNV deletion 23290073
esv2748245 CNV deletion 23290073
esv2748246 CNV deletion 23290073
esv2748247 CNV deletion 23290073
esv2748248 CNV deletion 23290073
esv2748249 CNV deletion 23290073
esv2748250 CNV deletion 23290073
esv2748258 CNV deletion 23290073
esv2748259 CNV deletion 23290073
esv2748260 CNV deletion 23290073
esv3393777 CNV duplication 20981092
esv5028 CNV loss 18987735
nsv1048814 CNV gain 25217958
nsv1051556 CNV gain 25217958
nsv1071129 CNV deletion 25765185
nsv1126354 CNV deletion 24896259
nsv518044 CNV gain 19592680
nsv563268 CNV loss 21841781
nsv563269 CNV loss 21841781
nsv563270 CNV loss 21841781
nsv563276 CNV loss 21841781
nsv563278 CNV gain 21841781
nsv563280 CNV loss 21841781
nsv563281 CNV loss 21841781
nsv64704 CNV deletion 16902084
nsv818996 CNV gain 17921354
nsv832724 CNV loss 17160897
nsv951925 CNV deletion 24416366
nsv951926 CNV deletion 24416366

Variation tolerance for F7 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F7 Gene

Disorders for F7 Gene

MalaCards: The human disease database

(35) MalaCards diseases for F7 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
factor vii deficiency
  • deficiency, stable
myocardial infarction
  • myocardial infarction, protection against
hemophilia a
  • factor viii deficiency
  • hemophilia a
hemorrhagic disease
  • hemorrhagic diathesis
- elite association - COSMIC cancer census association via MalaCards
Search F7 in MalaCards View complete list of genes associated with diseases


  • Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. {ECO:0000269 PubMed:10862079, ECO:0000269 PubMed:11091194, ECO:0000269 PubMed:11129332, ECO:0000269 PubMed:12472587, ECO:0000269 PubMed:14717781, ECO:0000269 PubMed:1634227, ECO:0000269 PubMed:18976247, ECO:0000269 PubMed:19432927, ECO:0000269 PubMed:19751712, ECO:0000269 PubMed:2070047, ECO:0000269 PubMed:21206266, ECO:0000269 PubMed:21372693, ECO:0000269 PubMed:26761581, ECO:0000269 PubMed:7974346, ECO:0000269 PubMed:7981691, ECO:0000269 PubMed:8043443, ECO:0000269 PubMed:8204879, ECO:0000269 PubMed:8242057, ECO:0000269 PubMed:8364544, ECO:0000269 PubMed:8652821, ECO:0000269 PubMed:8844208, ECO:0000269 PubMed:8883260, ECO:0000269 PubMed:8940045, ECO:0000269 PubMed:9414278, ECO:0000269 PubMed:9452082, ECO:0000269 PubMed:9576180}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for F7 Gene


Relevant External Links for F7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with F7: view

Publications for F7 Gene

  1. Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. (PMID: 18976247) Herrmann F.H. … Salazar-Sanchez L. (Haemophilia 2009) 3 4 46 64
  2. [The connection between Arg353Gln polymorphism of coagulation factor VII and recurrent miscarriages]. (PMID: 19323053) Seremak-Mrozikiewicz A. … Mrozikiewicz P.M. (Ginekol. Pol. 2009) 3 22 46 64
  3. The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study. (PMID: 19415820) Maitland-van der Zee A.H. … Eckfeldt J.H. (Pharmacogenet. Genomics 2009) 3 22 46 64
  4. Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women. (PMID: 17059418) Reiner A.P. … Nickerson D.A. (J. Thromb. Haemost. 2007) 3 22 46 64
  5. Coagulation factor VII and inflammatory markers in patients with coronary heart disease. (PMID: 17581323) EkstrAPm M. … Tornvall P. (Blood Coagul. Fibrinolysis 2007) 3 22 46 64

Products for F7 Gene

Sources for F7 Gene

Loading form....