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F5 Gene

protein-coding GIFtS: 63

GC01M167750

coagulation factor V (proaccelerin, labile factor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FVL ^²
OTTHUMP00000032547 ^²
PCCF ^²

Descriptions
Activated protein C cofactor ^², ³
Proaccelerin, labile factor ^³
coagulation factor V ^²
coagulation factor V (proaccelerin, labile factor) ^²
coagulation factor V jinjiang A2 domain ^²
factor V Leiden ^²

External Ids
HGNC: 3542¹
Entrez Gene: 2153²
UniProtKB: P12259³
Ensembl: ENSG00000198734⁷

Search outside databases for aliases for F5 gene

Previous GC identifers: GC01M167112 GC01M165134 GC01M166179 GC01M166670 GC01M166215

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F5:

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in

plasma, and is converted to the active form by the release of the activation peptide by thrombin

during coagulation. This generates a heavy chain and a light chain which are held together by

calcium ions. The activated protein is a cofactor that participates with activated coagulation

factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal

recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as

activated protein C resistance. [provided by RefSeq]

UniProtKB/Swiss-Prot: FA5_HUMAN, P12259

Function: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase

activity of factor Xa that results in the activation of prothrombin to thrombin

Gene Wiki entry for F5 (Factor_V)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F5 gene

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q23

F5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M167750: (about GC identifiers)

Start:	167,747,816 bp from pter
End:	167,822,393 bp from pter
Size:	74,578 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FA5_HUMAN, P12259 (See protein sequence)

Recommended Name: Coagulation factor V precursor

Size: 2224 amino acids; 251671 Da

Subunit: Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain,

non-covalently bound. The interaction between the two chains is calcium-dependent

Subcellular location: Secreted (By similarity)

PDB structures from and Proteopedia :

1CZS (3D)

1CZT (3D)

1CZV (3D)

1FV4 (3D)

1Y61 (3D)

Secondary accessions: A8K6E8 Q14285 Q2EHR5 Q5R346 Q5R347 Q6UPU6 Q8WWQ6

Post-translational modifications:

Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy

chain at the N-terminus and a light chain at the C-terminus)¹

Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant

activity¹

Activated protein C inactivates factor V and factor Va by proteolytic degradation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000121.2

ENSEMBL proteins:

ENSP00000356770 ENSP00000356771

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for F5
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Factor V Light Chain , Factor Va, Activated Protein C, Factor V Heavy Chain , Factor V)
	Human Recombinant Proteins from Abnova (F5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	EXP	3052293
GO:0031093	platelet alpha granule lumen	EXP	6946465

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Antibodies for F5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of F5
	Sigma-Aldrich Antibodies for F5
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Factor V Light Chain , Factor Va, Activated Protein C, Factor V Heavy Chain , Factor V), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F5)
	Search Novus for antibodies for F5

Assays for F5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P12259

ProtoNet protein and cluster: P12259

1 Blocks protein family: IPB000421 Coagulation factor 5/8 type C domain (FA58C)

UniProtKB/Swiss-Prot: FA5_HUMAN, P12259

Domain: Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats

Similarity: Belongs to the multicopper oxidase family

Similarity: Contains 3 F5/8 type A domains

Similarity: Contains 2 F5/8 type C domains

Similarity: Contains 6 plastocyanin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000130

Applied Biosystems Silencer® siRNAs for F5

Sigma-Aldrich siRNA and siRNA Panels for F5

Sigma-Aldrich shRNA for F5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000130
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000130
untagged cDNA clones in CMV expression vector (see all 2): NM_000130

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000130

UniProtKB/Swiss-Prot: FA5_HUMAN, P12259

Function: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase

activity of factor Xa that results in the activation of prothrombin to thrombin

Genatlas biochemistry entry for F5:

coagulation factor V (proaccelerin,labile factor),cofactor in the activation of prothrombin (F2) by

activated F10,colocalized and complexed with merin multimerin in platelets alpha-granules

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for F5):

	behavior/neurological	embryogenesis	growth/size	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	nervous system
skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005507	copper ion binding	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for F5 (Your Favorite Gene powered by Ingenuity)

Coagulation System

GeneDecks F5 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for F5

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007596	blood coagulation	TAS	9252393
GO:0008015	blood circulation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for F5:

Inhibitor

Browse Tocris compounds for F5
10/40 Novoseek chemical compound relationships for F5 gene (see all 40 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	82.00	332	9081677 (5), 15217806 (4), 10831587 (3), 15306149 (3) (see all 99)
homocysteine	73.95	133	11083858 (5), 15175797 (3), 2154269 (2), 10847236 (2) (see all 99)
gamma-carboxyglutamic acid	68.85	13	1498334 (2), 1905953 (1), 8180219 (1), 7999756 (1) (see all 8)
phospholipid	61.01	66	8456424 (4), 8206891 (2), 1412190 (2), 9731110 (2) (see all 48)
vtes	49.24	1	15130065 (1)
spectrozyme	47.21	1	2232257 (1)
hirugen	45.22	5	1590777 (3), 8662922 (2)
n-apc	44.29	1	15016779 (1)
cardiolipin	43.96	15	16395490 (1), 10990549 (1), 16512831 (1), 11487028 (1) (see all 13)
5-methyltetrahydrofolate	39.81	11	12514663 (1), 15198356 (1), 15188139 (1), 11872195 (1) (see all 9)

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2 PharmGKB drug compound relationships for F5 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
drotrecogin alfa	CO GN	15118525
oral contraceptives	CO GN	8639453 10073976

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000130

Sigma-Aldrich siRNA and siRNA Panels for F5

Sigma-Aldrich shRNA for F5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000130

REFSEQ mRNAs for F5 gene:

NM_000130.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000130

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000130
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000130
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000130

Additional cDNA sequence:

AJ297254.1 AJ297255.1 AK226079.1 AK291613.1 AK300469.1 CR626632.1 M14335.1 M16967.1

M94010.1

4 DOTS entries:

DT.455722 DT.100780251 DT.92428603 DT.95293061

24/135 AceView cDNA sequences (see all 135 ):

T28497 AV654769 CB162253 BE219652 AV650215 AI306468 AW291519 AL552613

AI692757 AA344458 AI796803 AU279657 H70968 CA390389 AW294470 CA395167

AV650378 CA393309 AW294101 CA395604 BP366398 CR626632 AA780062 AW451710

highest scoring ESTs for F5:

M16967 AU076606 AU279657 BI020494 BX492043 BX496193 M14335 AA334614 AA344458 AA676237

Unigene Cluster for F5:

Coagulation factor V (proaccelerin, labile factor)

Hs.30054 [show with all ESTs]

Unigene Representative Sequence: NM_000130

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000367796 ENST00000367797

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F5

¹ / ² / ³

8 probe-sets matching F5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62710_at²^{, 3}	U95-C	1	1.00	1.00	0.93	1.27	AI740541	0.40	1.00	0.76	1
35245_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.83	M16967	1.00	1.00	1.00	1
204713_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA910306	0.60	1.00	0.82	1
231029_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI740541	0.40	1.00	0.76	1
204714_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000130	0.60	1.00	0.82	1
204713_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231029_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204714_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATCAAAGT

SOURCE GeneReport for Unigene cluster: Hs.30054
Expression variation in blood from EXPOLDB for F5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F5 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	F5¹	--	coagulation factor V (proaccelerin, labile factor)	83.39(n) 75.54(a)	280687 NM_173879.2 NP_776304.1
rat (Rattus norvegicus)	F5¹	--	coagulation factor V (proaccelerin, labile factor)	75.45(n) 68.42(a)	304929 XM_222831.4 XP_222831.4
mouse (Mus musculus)	F5^{1, 5}	1 (86.60 cM)⁵	coagulation factor V^{1, 5}	78.46(n)¹ 72.66(a)¹	14067¹ NM_007976.2¹ NP_032002.1¹ AF040572⁵ AF040573⁵ (see all 19)
zebrafish (Danio rerio)	f5¹	--	coagulation factor V	56.23(n) 49.63(a)	327320 NM_001007208.2 NP_001007209.2

About this table Species with no ortholog for F5

ENSEMBL Gene Tree for F5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F5 gene

F8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/741 NCBI SNPs in F5 are shown (see all 741 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 340)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6030^1,2	A,C,F,H,O	167765599(-)	`TGCCTA/GTGGAC`	1	M/V	mis¹ ese³		15	MN EA NA EU WA	1418
	rs6033^1,2	C,F,H,O	167788477(+)	`CTTTCA/GTATTG`	1	M/T	mis¹		17	MN EA NA EU WA NS	1312
	rs2040444^1,2	A,C,F,H	167749060(+)	`tacacA/Gttaca`	1	--	ut3¹		8	EU EA NS NA	518
	rs2187952^1,2	A,C,F,H	167748574(+)	`AATACG/AAATAT`	1	--	ut3¹		6	NS EU EA WA	502
	rs4525^1,2	A,C,F,H	167778358(-)	`TAAGCA/GTAAGG`	1	H/R	mis¹ ese³		9	MN EA NS EU WA	2290
	rs6032^1,2	A,C,F,H	167778179(-)	`CCTGGA/GAGGAC`	1	K/E	mis¹		13	MN EA NS EU WA	2696
	rs4524^1,2	A,C,F,H	167778379(-)	`ATTCAA/GAAGTC`	1	K/R	mis¹ ese³		17	MN EA NS EU WA	2384
	rs6018^1,2	A,C,F,H	167778502(+)	`CTGAGT/GTCTTG`	1	T/N	mis¹ ese³		14	MN EU EA WA NS NA	1440
	rs9332604^1,2	C,F,H	167778046(-)	`TGTTAA/GCAATT`	1	N/S	mis¹		11	NS EU EA WA NA	984
--	rs13306334^1,2	C,F,H	167776763(-)	`CAGATC/TTCAGT`	1	L/F	mis¹ ese³		4	EU EA WA	404

About this table

HapMap Linkage Disequilibrium images for F5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612309 disorders: 227400 188055 601367 600880 188055

UniProtKB/Swiss-Prot: FA5_HUMAN, P12259

Defects in F5 are the cause of factor V deficiency (FA5D) [MIM:227400]; also known as

Owren parahemophilia. It is an hemorrhagic diastesis

Defects in F5 are the cause of thrombophilia due to activated protein C resistance

(THR-APCR) [MIM:188055]. THR-APCR is a hemostatic disorder due to defective degradation of factor

Va by activated protein C. It is characterized by a poor anticoagulant response to activated

protein C resulting in tendency to thrombosis

Defects in F5 are a cause of susceptibility to Budd-Chiari syndrome [MIM:600880].

Budd-Chiari syndrome is a spectrum of disease states, including anatomic abnormalities and

hypercoagulable disorders, resulting in hepatic venous outflow occlusion. Clinical manifestations

observed in the majority of patients include hepatomegaly, right upper quadrant pain, and

abdominal ascites

Defects in F5 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known

as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading

to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive

function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly

complex disease consisting of a group of heterogeneous disorders with multiple genetic and

environmental risk factors

10/98 Novoseek disease relationships for F5 gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
apc resistance	98.66	1932	10499894 (12), 9156566 (9), 10871461 (9), 9240602 (7) (see all 99)
thrombophilia	96.75	622	9820002 (3), 9350176 (3), 9577282 (3), 16256098 (3) (see all 99)
venous thrombosis	93.24	708	9471929 (7), 10477778 (6), 16758522 (6), 17200768 (6) (see all 99)
protein s deficiency	93.10	174	15706484 (3), 9746774 (3), 9241737 (2), 9607123 (2) (see all 99)
thrombosis	91.87	762	12180730 (6), 8592550 (5), 8774498 (4), 8671856 (4) (see all 99)
thromboembolism	91.65	493	9092318 (8), 12468175 (6), 10215560 (6), 11734673 (5) (see all 99)
protein c deficiency	90.76	133	7562967 (5), 9128811 (3), 8943855 (3), 14707707 (2) (see all 97)
antithrombin iii deficiency	86.00	46	17710975 (2), 12192310 (1), 15919499 (1), 18685442 (1) (see all 41)
coagulopathy	84.24	117	8429648 (3), 9531249 (3), 11700394 (2), 10229050 (2) (see all 99)
f5f8d	83.38	17	18056485 (2), 12717434 (2), 18590741 (1), 17287640 (1) (see all 15)

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3 PharmGKB disease relationships for F5 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Sepsis	CO GN	15118525
Thromboembolism	CO GN	11457466
venous thromboembolism	CO GN	8639453 10073976

About this table

Genatlas disease: F5

parahemophilia

GeneTests: F5

Factor V Leiden Thrombophilia

Human Gene Mutation Database: F5
Genetic Association Database: F5
Human Genome Epidemiology Navigator: F5 (705 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/3030 PubMed articles for F5 gene (see all 3030 ):

Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. (PubMed id 15534175)^{3, 4, 6} Casas J.P.... Sharma P. (2004)
Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C. (PubMed id 15118525)^{1, 3, 7} Yan S.B. and Nelson D.R. (2004)
Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma. (PubMed id 8713778)^{3, 4, 6} Lunghi B....Bernardi F. (1996)
Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. (PubMed id 8204629)^{1, 3, 4} Pittman D.D....Kaufman R.J. (1994)
[Effects of factor V Leiden mutations on prognosis in patients with acute myocardial infarction] (PubMed id 12101832)^{1, 3, 6} Baykan M....Erdol C. (2001)
A whole-blood homogeneous assay for the multiplex detection of the factor V G1691A and the prothrombin G20210A mutations. (PubMed id 16006096)^{1, 3, 6} Hobson-Peters J. and Toye P. (2005)
[Mutations of genes associated with thromboses in ischemic stroke in patients with primary antiphospholipid syndrome] (PubMed id 16320685)^{1, 3, 6} Kalashnikova L.A....Nasonov E.L. (2005)
-455G/A beta-fibrinogen gene polymorphism, factor V Leiden, prothrombin G20210A mutation and MTHFR C677T, and placental vascular complications. (PubMed id 15091001)^{1, 3, 6} Camilleri R.S....Cohen H. (2004)
[Occurrence of gene mutations in factor V Leiden, prothrombin and methylenetetrahydrofolate reductase in patients with pre-eclampsia] (PubMed id 12879654)^{1, 3, 6} Prochazka M....Slavik L. (2003)
[Cerebral venous thrombosis and factor V Leiden mutation] (PubMed id 11953127)^{1, 3, 6} Meng Q. and Pu C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2153	HGNC: 3542	AceView: F5	Ensembl:ENSG00000198734	euGenes: HUgn2153
ECgene: F5	H-InvDB: F5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Factor_V
GeneReviews	http://www.genetests.org/query?gene=F5
SeattleSNPs	http://pga.gs.washington.edu/data/f5/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=F5

Licensable Technologies for F5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F5		Antibodies for F5
	Explore super-pooled esiRNAs		Proteins for F5
	Lentivirus-delivered shRNAs for F5		Small molecules for F5
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (F5)
	Antibodies (F5)
	Chimera RNAi (F5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Factor V Light Chain , Factor Va, Activated Protein C, Factor V Heavy Chain , Factor V)
	Antibodies (Factor V Light Chain , Factor Va, Activated Protein C, Factor V Heavy Chain , Factor V)

Search OriGene for F5

Search Tocris compounds for F5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for F5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
F5 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

F5 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for F5

Summaries
for F5

Genomic Location
for F5

Proteins
for F5

Protein Domains/
Families
for F5

Gene Function
for F5

Pathways & Interactions
for F5

Drugs & Compounds
for F5

Transcripts
for F5

Expression
for F5

Orthologs
for F5

Paralogs
for F5

SNPs/Variants
for F5

Disorders & Mutations
for F5

Medical News
for F5

Publications
for F5

Search for F5

Genome Databases showing F5

Other Databases showing F5

Specialized Databases showing F5

Licensable Technologies
for F5

Services
for F5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F5 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor F5

Summariesfor F5

Genomic Locationfor F5

Proteinsfor F5

Protein Domains/Familiesfor F5

Gene Functionfor F5

Pathways & Interactionsfor F5

Drugs & Compoundsfor F5

Transcriptsfor F5

Expression for F5

Orthologsfor F5

Paralogsfor F5

SNPs/Variantsfor F5

Disorders & Mutationsfor F5

Medical Newsfor F5

Publicationsfor F5

Search for F5

Genome Databases showing F5

Other Databases showing F5

Specialized Databases showing F5

Licensable Technologiesfor F5

Servicesfor F5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F5

Summaries
for F5

Genomic Location
for F5

Proteins
for F5

Protein Domains/
Families
for F5

Gene Function
for F5

Pathways & Interactions
for F5

Drugs & Compounds
for F5

Transcripts
for F5

Expression
for F5

Orthologs
for F5

Paralogs
for F5

SNPs/Variants
for F5

Disorders & Mutations
for F5

Medical News
for F5

Publications
for F5

Licensable Technologies
for F5

Services
for F5