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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F3 Gene

protein-coding   GIFtS: 67
GCID: GC01M094994

Coagulation Factor III (Thromboplastin, Tissue Factor)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coagulation Factor III (Thromboplastin, Tissue Factor)1 2     Tissue Factor2
TF2 3     Thromboplastin3
TFA2 5     CD142 Antigen3
CD1422     Coagulation Factor III3

External Ids:    HGNC: 35411   Entrez Gene: 21522   Ensembl: ENSG000001175257   OMIM: 1343905   UniProtKB: P137263   

Export aliases for F3 gene to outside databases

Previous GC identifers: GC01M095396 GC01M094200 GC01M094345 GC01M094466 GC01M094706 GC01M093116


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F3 Gene:
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to
initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation
factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the
coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease
cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional
when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and
cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not
been described. Alternate splicing results in multiple transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for F3 Gene: 
F3 (coagulation factor III (thromboplastin, tissue factor)) is a protein-coding gene. Diseases associated with F3 include heparin-induced thrombocytopenia, and carotid artery thrombosis, and among its related super-pathways are Complement and Coagulation Cascades and Intrinsic Pathway. GO annotations related to this gene include phospholipid binding and cell surface binding.

UniProtKB/Swiss-Prot: TF_HUMAN, P13726
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa]
complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by
initiating the cell-surface assembly and propagation of the coagulation protease cascade

Gene Wiki entry for F3 (Tissue factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F3 gene promoter:
         AREB6   Tal-1   Pax-5   MyoD   STAT3   E47   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): F3 promoter sequence
   Search SABiosciences Chromatin IP Primers for F3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22-p21   Ensembl cytogenetic band:  1p21.3   HGNC cytogenetic band: 1p22-p21

F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094994:  view genomic region     (about GC identifiers)

Start:
94,994,732 bp from pter      End:
95,007,413 bp from pter
Size:
12,682 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TF_HUMAN, P13726 (See protein sequence)
Recommended Name: Tissue factor precursor  
Size: 295 amino acids; 33068 Da
Subunit: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X
and activates coagulation in the presence of activated factor VII
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
6/42 PDB 3D structures from and Proteopedia for F3 (see all 42):
1AHW (3D)        1BOY (3D)        1DAN (3D)        1FAK (3D)        1J9C (3D)        1JPS (3D)    
Secondary accessions: D3DT47 Q6FHG2 Q86WH4
Alternative splicing: 2 isoforms:  P13726-1   P13726-2   

Explore the universe of human proteins at neXtProt for F3: NX_P13726

Explore proteomics data for F3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13726

  • F3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    F3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171567.1  NP_001984.1  

    ENSEMBL proteins: 
     ENSP00000334145   ENSP00000359226  
    Reactome Protein details: P13726
    Human Recombinant Protein Products for F3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for F3 (Coagulation Factor III/Tissue Factor)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for F3
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for F3 
    OriGene Custom Protein Services for F3
    GenScript Custom Purified and Recombinant Proteins Services for F3
    Novus Biologicals F3 Proteins
    Novus Biologicals F3 Lysate
    Sino Biological Recombinant Protein for F3
    Sino Biological Cell Lysate for F3 
    ProSpec Recombinant Protein for F3
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA19065458
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA17898544
    GO:0016021integral to membrane IEA--
    GO:0031012extracellular matrix IDA2704749

    F3 for ontologies           About GeneDecksing



    F3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of F3
    R&D Systems Antibodies for F3 (Coagulation Factor III/Tissue Factor)
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    LSBio Antibodies in human, mouse, rat for F3 

    Assay Products for F3: 
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    R&D Systems ELISAs for F3 (Coagulation Factor III/Tissue Factor)         (see all)
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    5 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold
     IPR001187 Tissue_factor
     IPR016354 Tissue_fac/coagulation_fac-3

    Graphical View of Domain Structure for InterPro Entry P13726

    ProtoNet protein and cluster: P13726

    1 Blocks protein domain: IPB001187 Tissue factor

    UniProtKB/Swiss-Prot: TF_HUMAN, P13726
    Similarity: Belongs to the tissue factor family


    F3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF_HUMAN, P13726
    Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa]
    complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by
    initiating the cell-surface assembly and propagation of the coagulation protease cascade
    Induction: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators
    interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a
    component of cellular immune response

         Genatlas biochemistry entry for F3:
    coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI3455766
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IDA17469850
         
    F3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for F3:
     Increased S DNA content 

         15 MGI mutant phenotypes (inferred from 7 alleles(MGI details for F3):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  normal  tumorigenesis  vision/eye 

    F3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for F3: F3tm1Gjb F3tm1Dco F3tm1Jld F3tm1Dwr F3tm1.1Dwr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for F3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for F3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for F3 

    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate F3 (see all 37):
    hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-223 hsa-miR-1244 hsa-miR-93 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidF3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of F3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for F3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    2Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.59
    Blood Coagulation Signaling Pathways0.51
    3Common Pathway
    Extrinsic Prothrombin Activation Pathway0.69
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Toll Comparative Pathway
    Immune response IL-1 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for F3
        Immune response IL-1 signaling pathway

    1 R&D Systems Pathway for F3
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F3
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade

    1 GeneGo (Thomson Reuters) Pathway for F3
        Immune response IL-1 signaling pathway

    1 BioSystems Pathway for F3
        Complement and Coagulation Cascades


    3        Reactome Pathways for F3
        Hemostasis
    Extrinsic Pathway
    Formation of Fibrin Clot (Clotting Cascade)


    1         Kegg Pathway  (Kegg details for F3):
        Complement and coagulation cascades


    F3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for F3 (P137263 ENSP000003341454) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F7P087093, ENSP000003647314I2D: score=5 STRING: ENSP00000364731
    FANCBQ8NB913, ENSP000003268194I2D: score=1 STRING: ENSP00000326819
    F10P007423, ENSP000003647094I2D: score=1 STRING: ENSP00000364709
    FLNAP213333, ENSP000003588664I2D: score=2 STRING: ENSP00000358866
    PLGP007473, ENSP000003089384I2D: score=2 STRING: ENSP00000308938
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA17898544
    GO:0002541activation of plasma proteins involved in acute inflammatory response IDA17469850
    GO:0002543activation of blood coagulation via clotting cascade IC17469850
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA17898544
    GO:0007596blood coagulation TAS--

    F3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for F3 (TF)

    4 DrugBank Compounds for F3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--6658368 1586032 13713641
    2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE-- --target--10592235
    [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA-- --target--10592235
    {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID-- --target--10592235

    10/134 Novoseek inferred chemical compound relationships for F3 gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 91 858 14987914 (4), 16454558 (4), 15795541 (3), 7923650 (3) (see all 99)
    heparin 90.5 923 10235445 (7), 10704648 (6), 15306747 (5), 8630391 (5) (see all 99)
    ecarin 84.7 32 17102656 (2), 7900080 (1), 12643328 (1), 12960616 (1) (see all 30)
    argatroban 84.4 64 11307810 (2), 19719819 (2), 11994559 (1), 15886289 (1) (see all 59)
    hirudin 83.2 81 1658403 (3), 15718352 (3), 16919046 (2), 8409044 (2) (see all 66)
    mnpt 78.6 4 9459336 (2), 10926265 (1), 9059355 (1)
    warfarin 77.2 95 9245222 (3), 10702890 (2), 8503731 (2), 1562730 (2) (see all 67)
    hemochron 76.3 11 19398428 (2), 12533064 (1), 9535388 (1), 17686264 (1) (see all 10)
    ristocetin 71.2 27 10335531 (1), 12185511 (1), 11913569 (1), 12010430 (1) (see all 24)
    d-phe-phe-arg-chloromethyl ketone 68.7 2 11258943 (1), 9819025 (1)

    Search CenterWatch for drugs/clinical trials and news about F3 / TF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for F3 gene (2 alternative transcripts): 
    NM_001178096.1  NM_001993.4  

    Unigene Cluster for F3:

    Coagulation factor III (thromboplastin, tissue factor)
    Hs.62192  [show with all ESTs]
    Unigene Representative Sequence: NM_001993
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334047(uc001dqp.2 uc001dqq.2 uc001dqr.3 uc001dqs.3)
    ENST00000370207 ENST00000478217 ENST00000480356(uc001dqt.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate F3 (see all 37):
    hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-223 hsa-miR-1244 hsa-miR-93 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidF3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F3

    Additional mRNA sequence: 

    AF487337.1 AF497569.1 AF497570.1 AF497571.1 AK310918.1 AK312638.1 AY940729.1 AY940730.1 
    AY940731.1 BC011029.1 BT019808.1 CR541792.1 J02931.1 M16553.1 M27436.1 X07680.1 

    11 DOTS entries:

    DT.413467  DT.91748572  DT.100833527  DT.95258172  DT.100787064  DT.100034264  DT.91657428  DT.100045137 
    DT.91696356  DT.91748574  DT.95250461 

    24/147 AceView cDNA sequences (see all 147):

    BM981095 BI335812 CR590388 X07680 BM763298 CA438772 AA373308 CD677037 
    CA437990 F02583 R46493 AW338870 BM769013 CA307794 BM988577 F06293 
    AI573071 BP351103 BP352745 BX359436 BM983975 AA351232 BP355971 BP355632 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for F3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:              -     -     -           -                 -                                       
    SP2:                                      -                 -                                       
    SP3:              -     -     -           -                 -     -                                 
    SP4:                                      -                 -     -                                 
    SP5:                                                                                                


    ECgene alternative splicing isoforms for F3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F3 expression in normal human tissues (normalized intensities)      F3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAAAGTA
    F3 Expression
    About this image


    F3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/calyx   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/calyx   
     
     Smooth Muscle (Muscoskeletal System)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   

    See F3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F3

    SOURCE GeneReport for Unigene cluster: Hs.62192

    UniProtKB/Swiss-Prot: TF_HUMAN, P13726
    Tissue specificity: Lung, placenta and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including F3 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for F3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F31 , 5 coagulation factor III1, 5 69.42(n)1
    56.83(a)1
      3 (52.94 cM)5
    140661  NM_010171.31  NP_034301.31 
     1217235375 
    chicken
    (Gallus gallus)
    Aves F31 coagulation factor III (thromboplastin, tissue factor) 55.64(n)
    47.47(a)
      429084  XM_426640.1  XP_426640.1 
    lizard
    (Anolis carolinensis)
    Reptilia F36
    Uncharacterized protein
    39(a)
    1 ↔ 1
    4(89102397-89117634)
    zebrafish
    (Danio rerio)
    Actinopterygii f3b1 coagulation factor IIIb 49.63(n)
    38.76(a)
      550423  NM_001017728.1  NP_001017728.1 


    ENSEMBL Gene Tree for F3 (if available)
    TreeFam Gene Tree for F3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F3 gene

    F3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for F3
    PGOHUM00000249654


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/323 SNPs in F3 are shown (see all 323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57762241,2
    C--93119445(+) AACCTC/-CAGGC 2 -- int12Minor allele frequency- -:0.39NA CSA 46
    rs23914241,2
    C,F--93119447(-) CTGCCC/G/TGGAGG 2 -- int11NA 48
    rs668557461,2
    C--93119447(+) CCTCC-/AGGCAG 2 -- int10--------
    rs589270221,2
    C--94995630(+) AAAAA-/AAAGCTTT 2 -- cds10--------
    rs665641131,2
    C--94995630(+) GTCTC-/AAAAAAAA 4 -- ut311Minor allele frequency- AAA:0.00NA 2
    rs105370051,2
    C--94996860(+) gtttc-/TTttttt 2 -- int11Minor allele frequency- TT:0.00NA 2
    rs1417049741,2
    C--94996860(+) GTTTC-/TTTTTTT 2 -- int10--------
    rs39176071,2
    C--95004589(-) TAATAT/-TTGAG 2 -- int12Minor allele frequency- -:0.01NS 90
    rs729683561,2
    C--95008532(+) TATCTC/TGTTTA 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs765547071,2
    --95017818(+) GTAGAA/GAGCAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for F3 (94994732 - 95007413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for F3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1899CNV Insertion18451855
    dgv270n71CNV Loss21882294
    nsv871764CNV Loss21882294


    Human Gene Mutation Database (HGMD): F3
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for F3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 134390    OMIM disorders: --

    20/254 diseases for F3 (see all 254):    About MalaCards
    heparin-induced thrombocytopenia    carotid artery thrombosis    antiphospholipid syndrome    factor xii deficiency
    factor x deficiency    hantavirus pulmonary syndrome    tetrology of fallot    compton-north congenital myopathy
    hemorrhagic disease    disseminated intravascular coagulation    hemophilia    factor vii deficiency
    acquired hemophilia    hemophilia b    factor xi deficiency    factor v deficiency
    sagittal sinus thrombosis    crimean-congo hemorrhagic fever    fournier gangrene    factor xiii deficiency

    20/23 diseases from the University of Copenhagen DISEASES database for F3 (see all 23):
    Disseminated intravascular coagulation     Thrombocytopenia     Vascular disease     Antiphospholipid syndrome
    Heart disease     Lupus erythematosus     Factor VII deficiency     Factor XI deficiency
    Hemophilia B     Factor XII deficiency     Von Willebrand's disease     Brain disease
    Cancer     Liver disease     Factor X deficiency     Vitamin K deficiency hemorrhagic disease
    Connective tissue disease     Respiratory failure     Factor VIII deficiency     Kidney failure

    F3 for disorders           About GeneDecksing

    10/96 Novoseek inferred disease relationships for F3 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    partial thromboplastin time prolonged 91.4 84 9084708 (3), 12972821 (3), 2301750 (1), 2110553 (1) (see all 78)
    coagulopathy 89.1 128 8192064 (2), 8725725 (2), 19901655 (2), 18687038 (2) (see all 99)
    thrombosis 85.5 272 8911269 (4), 16466951 (4), 18610631 (3), 17694958 (3) (see all 99)
    bleeding 85.5 457 9031451 (4), 10934288 (4), 10389296 (3), 1625090 (3) (see all 99)
    disseminated intravascular coagulation 84.1 68 16828603 (2), 14758173 (2), 8180381 (1), 8037186 (1) (see all 61)
    apc resistance 81 49 11119756 (1), 11583314 (1), 11816542 (1), 15947551 (1) (see all 45)
    pt prolonged 80.9 8 8826562 (1), 8503731 (1), 17393015 (1), 7841574 (1) (see all 8)
    thrombophilia 80.7 51 12028043 (3), 16479463 (2), 15617024 (2), 7479207 (1) (see all 45)
    antiphospholipid syndrome 77 37 8911269 (3), 7479207 (1), 9522600 (1), 12652293 (1) (see all 32)
    thrombocytopenia 77 91 7634703 (1), 7489960 (1), 8826562 (1), 8882480 (1) (see all 90)

    Genetic Association Database (GAD): F3
    Human Genome Epidemiology (HuGE) Navigator: F3 (44 documents)

    Export disorders for F3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F3 gene, integrated from 9 sources (see all 3162):
    (articles sorted by number of sources associating them with F3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2, 9 Eisenreich A....Rauch U. (2009)
    2. Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. (PubMed id 19027114)1, 4, 9 Undas A....Tracz W. (2008)
    3. Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PubMed id 16239598)1, 4, 9 Malarstig A....Siegbahn A. (2005)
    4. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. (PubMed id 12652293)1, 2, 9 Bogdanov V.Y....Nemerson Y. (2003)
    5. A genome-wide association search for type 2 diabetes g enes in African Americans. (PubMed id 22238593)1, 4 Palmer N.D....Sladek R. (2012)
    6. Genetic predictors of fibrin D-dimer levels in health y adults. (PubMed id 21502573)1, 4 Smith N.L....Hayward C. (2011)
    7. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    10. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2152 HGNC: 3541 AceView: F3 Ensembl:ENSG00000117525 euGenes: HUgn2152
    ECgene: F3 Kegg: 2152 H-InvDB: F3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for F3 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/f3/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF
    Wikipedia http://en.wikipedia.org/wiki/Tissue_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for F3 gene:
    Search GeneIP for patents involving F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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