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F3 Gene

protein-coding GIFtS: 69

GC01M094706

coagulation factor III (thromboplastin, tissue factor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD142 ^¹, ²
OTTHUMP00000012426 ^²
TF ^², ³
TFA ^², ⁵
Thromboplastin ^³

Descriptions
CD142 antigen ^³
Coagulation factor III ^², ³
coagulation factor III (thromboplastin, tissue factor) ^²
tissue factor ^²

External Ids
HGNC: 3541¹
Entrez Gene: 2152²
UniProtKB: P13726³
Ensembl: ENSG00000117525⁷

Search outside databases for aliases for F3 gene

Previous GC identifers: GC01M095396 GC01M094200 GC01M094345 GC01M094466

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F3:

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables

cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor

for the coagulation factor VII. The resulting complex provides a catalytic event that is

responsible for initiation of the coagulation protease cascades by specific limited proteolysis.

Unlike the other cofactors of these protease cascades, which circulate as nonfunctional

precursors, this factor is a potent initiator that is fully functional when expressed on cell

surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and

cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital

deficiency has not been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The

[TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in

normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation

protease cascade

Gene Wiki entry for F3 (Tissue_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F3 gene

Entrez Gene cytogenetic band: 1p22-p21 Ensembl cytogenetic band: 1p21.3 HGNC cytogenetic band: 1p22-p21

F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M094706: (about GC identifiers)

Start:	94,767,461 bp from pter
End:	94,779,903 bp from pter
Size:	12,443 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TF_HUMAN, P13726 (See protein sequence)

Recommended Name: Tissue factor precursor

Size: 295 amino acids; 33068 Da

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1AHW (3D)

1BOY (3D)

1DAN (3D)

1FAK (3D)

1J9C (3D)

1JPS (3D)

1NL8 (3D)

1O5D (3D)

1TFH (3D)

1UJ3 (3D)

1W0Y (3D)

1W2K (3D)

1WQV (3D)

1WSS (3D)

1WTG (3D)

1WUN (3D)

1WV7 (3D)

1Z6J (3D)

2A2Q (3D)

2AEI (3D)

2AER (3D)

2B7D (3D)

2B8O (3D)

2C4F (3D)

2CEF (3D)

2CEH (3D)

2CEZ (3D)

2CFJ (3D)

2EC9 (3D)

2F9B (3D)

2FIR (3D)

2FLB (3D)

2FLR (3D)

2HFT (3D)

2PUQ (3D)

2ZP0 (3D)

2ZWL (3D)

2ZZU (3D)

3ELA (3D)

Secondary accessions: Q6FHG2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001984.1

ENSEMBL proteins:

ENSP00000334145 ENSP00000359226

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for F3 (Coagulation Factor III/Tissue Factor)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tissue Factor)
	Human Recombinant Proteins from Abnova (F3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	NAS	10896200
GO:0016021	integral to membrane	TAS	3037536

About this table

Antibodies for F3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of F3
	Sigma-Aldrich Antibodies for F3
	R&D Systems Antibodies for F3 (Coagulation Factor III/Tissue Factor)
	Antibodies from Abcam (Tissue Factor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F3)
	Novus Biologicals Antibodies for F3

Assays for F3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for F3 (Coagulation Factor III/Tissue Factor) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13726

ProtoNet protein and cluster: P13726

1 Blocks protein family: IPB001187 Tissue factor

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Similarity: Belongs to the tissue factor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001993

Applied Biosystems Silencer® siRNAs for F3

Sigma-Aldrich siRNA and siRNA Panels for F3

Sigma-Aldrich shRNA Panels and shRNA for F3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for F3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001993
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001993
untagged cDNA clone in CMV expression vector: NM_001993

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001993

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The

[TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in

normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation

protease cascade

Induction: TF expression is highly dependent upon cell type. TF can also be induced by the

inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and

vascular endothelial cells as a component of cellular immune response

Genatlas biochemistry entry for F3:

coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing

with F7

15/17 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for F3) (see all 17 ):

	behavior/neurological	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	nervous system	normal	skin/coat/nails

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for F3 (Your Favorite Gene powered by Ingenuity)

Coagulation System

GeneDecks F3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for F3

5/98 Interacting proteins for F3 (ENSP00000334145³) via UniProtKB, MINT, and/or STRING (see all 98 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F10	ENSP00000364709³	STRING (score=.999)
F7	ENSP00000364731³	STRING (score=.999)
IGKC	ENSP00000374777³	STRING (score=.999)
TFPI	ENSP00000233156³	STRING (score=.998)
IGHG1	ENSP00000374990³	STRING (score=.995)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007598	blood coagulation, extrinsic pathway	EXP	7598447

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for F3
10/32 Novoseek chemical compound relationships for F3 gene (see all 32 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	90.90	799	14987914 (4), 16454558 (4), 15795541 (3), 7923650 (3) (see all 99)
mnpt	79.05	4	9459336 (2), 10926265 (1), 9059355 (1)
appt	67.37	4	12627886 (1), 10414674 (1), 10329529 (1), 18639059 (1)
d-phe-phe-arg-chloromethyl ketone	66.29	2	11258943 (1), 9819025 (1)
thrombofax	65.60	2	9212356 (1), 2270531 (1)
gamma-carboxyglutamic acid	63.84	22	1874730 (3), 8868516 (3), 9280313 (1), 8647260 (1) (see all 10)
dabigatran	62.02	3	17598008 (1), 17061960 (1), 17950801 (1)
phospholipid	59.32	129	10613654 (5), 1874730 (4), 16529959 (3), 15924438 (3) (see all 74)
napsagatran	56.61	3	12871353 (2), 11372586 (1)
carbetimer	54.12	1	2198795 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001993

Sigma-Aldrich siRNA and siRNA Panels for F3

Sigma-Aldrich shRNA Panels and shRNA for F3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001993

REFSEQ mRNAs for F3 gene:

NM_001993.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001993

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001993
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001993
                                 untagged cDNA clone in CMV expression vector: NM_001993

Additional cDNA sequence:

AF487337.1 AF497569.1 AF497570.1 AF497571.1 AK310918.1 AK312638.1 AY940729.1 AY940730.1

AY940731.1 BC011029.1 BT019808.1 CR541792.1 CR590388.1 J02931.1 M16553.1 M27436.1

X07680.1

11 DOTS entries:

DT.413467 DT.91748572 DT.100833527 DT.95258172 DT.100787064 DT.100034264 DT.91657428 DT.91696356

DT.100045137 DT.91748574 DT.95250461

24/147 AceView cDNA sequences (see all 147 ):

R46493 BM763298 CR590388 BM981095 F02583 F06293 BI335812 BM988577

AA373308 CA307794 CA437990 X07680 CA438772 AI573071 AW338870 BM769013

CD677037 AI924814 BP363123 AI720113 BI913529 AF497571 BP356096 BG506479

highest scoring ESTs for F3:

J02931 AF487337 AF497569 AF497570 AL133885 AU098605 AU280079 AW238813 BC011029 BE769960

Unigene Cluster for F3:

Coagulation factor III (thromboplastin, tissue factor)

Hs.62192 [show with all ESTs]

Unigene Representative Sequence: NM_001993

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for F3 (see all 8 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:					-		-		-				-						-
SP2:													-						-
SP3:					-		-		-				-						-		-
SP4:													-						-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for F3

2 Ensembl transcripts including schematic representations:

ENST00000334047 ENST00000370207

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F3

¹ / ² / ³

5 probe-sets matching F3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36543_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.63	J02931	1.00	1.00	1.00	1
73626_f_at²^{, 3}	U95-D	1145	0.94	0.01	0.13	1.40	AA582528	0.20	0.06	0.15	1
204363_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001993	0.60	1.00	0.82	1
204363_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1564391_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGGAAAGTA

SOURCE GeneReport for Unigene cluster: Hs.62192
Expression variation in blood from EXPOLDB for F3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F3¹	--	coagulation factor III (thromboplastin, tissue factor)	82.08(n) 72.6(a)	490153 NM_001024640.1 NP_001019811.1
chimpanzee (Pan troglodytes)	F3¹	--	coagulation factor III (thromboplastin, tissue factor)	99.1(n) 98.31(a)	457038 XM_001156450.1 XP_001156450.1
cow (Bos taurus)	F3¹	--	coagulation factor III (thromboplastin, tissue factor)	79.45(n) 70.3(a)	784008 XM_001252442.1 XP_001252443.1
rat (Rattus norvegicus)	F3¹	--	coagulation factor III (thromboplastin, tissue factor)	67.96(n) 57.04(a)	25584 NM_013057.2 NP_037189.2
mouse (Mus musculus)	F3^{1, 5}	3 (50.00 cM)⁵	coagulation factor III^{1, 5}	69.66(n)¹ 56.83(a)¹	14066¹ NM_010171.2¹ NP_034301.2¹ AA409063⁵ AI642673⁵ (see all 17)

About this table Species with no ortholog for F3

ENSEMBL Gene Tree for F3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/118 NCBI SNPs in F3 are shown (see all 118 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3354^1,2	A,C,F,O	94768407(+)	`CCATTC/TGTTAC`	1	--	ut3¹ ese³		24	NA MN EU EA WA NS	3664
--	rs841691^1,2	A,C,F	94767999(+)	`gatcaC/Actgag`	1	--	ut3¹ ese³		2	NS	94
	rs3761955^1,2	A,C,F	94781243(+)	`TCGAAG/ACAGAA`	1	--	ng3¹		8	NS	758
	rs5901^1,2	C,F,H	94771338(-)	`ATGAAC/TGGACT`	1	R/W	mis¹ ese³		10	MN EU EA WA	1108
	rs3917604^1,2	C,F,H	94778507(-)	`GCACTA/GCAAAT`	1	T/A	mis¹ ese³		7	NS EU EA WA NA	554
	rs3789683^1,2	C,F,H	94768650(+)	`CCACTC/TCTGCC`	1	G/E	mis¹ ese³		8	EU EA WA	832
--	rs841692^1,2	A,C,F	94768079(+)	`CTTGGT/CGTGGT`	1	--	ut3¹		1	NA	44
	rs1361600^1,2	A,C,F	94780506(-)	`GGCCAA/GGTATT`	1	--	ng3¹ tfbs³		7	EA NS MN NA	2158
	rs958587^1,2	A,C,F	94781733(-)	`AATGAC/TTTTAG`	1	--	ng3¹		16	NS NA EA EU WA	1540
--	rs3917633^1,2	A,C,F	94768173(-)	`tagcaC/Tgatct`	1	--	ut3¹ ese³		3	NS NA	134

About this table

HapMap Linkage Disequilibrium images for F3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134390

10/96 Novoseek disease relationships for F3 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
partial thromboplastin time prolonged	91.39	79	9084708 (3), 12972821 (3), 2301750 (1), 2110553 (1) (see all 73)
coagulopathy	88.80	115	8192064 (2), 8725725 (2), 14980916 (2), 19176989 (2) (see all 95)
thrombosis	85.18	247	8911269 (4), 16466951 (4), 18610631 (3), 17694958 (3) (see all 99)
bleeding	85.08	421	9031451 (4), 10934288 (4), 10389296 (3), 1625090 (3) (see all 99)
disseminated intravascular coagulation	83.85	67	16828603 (2), 14758173 (2), 8180381 (1), 8037186 (1) (see all 60)
apc resistance	81.43	48	11119756 (1), 11583314 (1), 11816542 (1), 15947551 (1) (see all 44)
thrombophilia	80.37	47	12028043 (3), 16479463 (2), 15617024 (2), 7479207 (1) (see all 41)
prothrombin increased	79.53	8	8826562 (1), 8503731 (1), 17393015 (1), 7841574 (1) (see all 8)
thrombocytopenia	76.69	87	7914411 (1), 7634703 (1), 7489960 (1), 8826562 (1) (see all 86)
antiphospholipid syndrome	76.01	34	8911269 (3), 7479207 (1), 9522600 (1), 12652293 (1) (see all 29)

About this table

Human Gene Mutation Database: F3
Genetic Association Database: F3
Human Genome Epidemiology Navigator: F3 (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2228 PubMed articles for F3 gene (see all 2228 ):

Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PubMed id 16239598)^{1, 3, 6} Malarstig A....Siegbahn A. (2005)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Genetic factors contribute to bleeding after cardiac surgery. (PubMed id 15892865)^{3, 6} Welsby I.J....Stafford-Smith M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant. (PubMed id 9925787)^{3, 4} Zhang E.... Tulinsky A. (1999)
The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution. (PubMed id 8609606)^{3, 4} Muller Y.A.... de Vos A.M. (1996)
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. (PubMed id 8598903)^{3, 4} Banner D.W.... Kirchhofer D. (1996)
Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. (PubMed id 8086403)^{3, 4} Muller Y.A.... de Vos A.M. (1994)
Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. (PubMed id 2719931)^{3, 4} Mackman N.... Edgington T.S. (1989)
Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. (PubMed id 3166978)^{3, 4} Bach R.... Nemerson Y. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2152	HGNC: 3541	AceView: F3	Ensembl:ENSG00000117525	euGenes: HUgn2152
ECgene: F3	H-InvDB: F3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for F3	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/f3/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF
Wikipedia	http://en.wikipedia.org/wiki/Tissue_factor

Licensable Technologies for F3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F3		Antibodies for F3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for F3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Chimera RNAi (F3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Tissue Factor)

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for F3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
F3 Gene at Home site.
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F3 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for F3

Summaries
for F3

Genomic Location
for F3

Proteins
for F3

Protein Domains/
Families
for F3

Gene Function
for F3

Pathways & Interactions
for F3

Drugs & Compounds
for F3

Transcripts
for F3

Expression
for F3

Orthologs
for F3

Paralogs
for F3

SNPs/Variants
for F3

Disorders & Mutations
for F3

Medical News
for F3

Publications
for F3

Search for F3

Genome Databases showing F3

Other Databases showing F3

Specialized Databases showing F3

Licensable Technologies
for F3

Services
for F3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F3 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor F3

Summariesfor F3

Genomic Locationfor F3

Proteinsfor F3

Protein Domains/Familiesfor F3

Gene Functionfor F3

Pathways & Interactionsfor F3

Drugs & Compoundsfor F3

Transcriptsfor F3

Expression for F3

Orthologsfor F3

Paralogsfor F3

SNPs/Variantsfor F3

Disorders & Mutationsfor F3

Medical Newsfor F3

Publicationsfor F3

Search for F3

Genome Databases showing F3

Other Databases showing F3

Specialized Databases showing F3

Licensable Technologiesfor F3

Servicesfor F3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F3

Summaries
for F3

Genomic Location
for F3

Proteins
for F3

Protein Domains/
Families
for F3

Gene Function
for F3

Pathways & Interactions
for F3

Drugs & Compounds
for F3

Transcripts
for F3

Expression
for F3

Orthologs
for F3

Paralogs
for F3

SNPs/Variants
for F3

Disorders & Mutations
for F3

Medical News
for F3

Publications
for F3

Licensable Technologies
for F3

Services
for F3