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F3 Gene

protein-coding   GIFtS: 68
GCID: GC01M094994

Coagulation Factor III (Thromboplastin, Tissue Factor)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coagulation Factor III (Thromboplastin, Tissue Factor)1 2     Tissue Factor2
TF2 3     Thromboplastin3
TFA2 5     CD142 Antigen3
CD1422     Coagulation Factor III3

External Ids:    HGNC: 35411   Entrez Gene: 21522   Ensembl: ENSG000001175257   OMIM: 1343905   UniProtKB: P137263   

Export aliases for F3 gene to outside databases

Previous GC identifers: GC01M095396 GC01M094200 GC01M094345 GC01M094466 GC01M094706 GC01M093116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for F3 Gene:
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to
initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation
factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the
coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease
cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional
when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and
cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not
been described. Alternate splicing results in multiple transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for F3 Gene:
F3 (coagulation factor III (thromboplastin, tissue factor)) is a protein-coding gene. Diseases associated with F3 include carotid artery thrombosis, and heparin-induced thrombocytopenia. GO annotations related to this gene include phospholipid binding and protease binding.

UniProtKB/Swiss-Prot: TF_HUMAN, P13726
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa]
complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by
initiating the cell-surface assembly and propagation of the coagulation protease cascade

Gene Wiki entry for F3 (Tissue factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the F3 gene promoter:
         AREB6   Tal-1   Pax-5   MyoD   STAT3   E47   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): F3 promoter sequence
   Search Chromatin IP Primers for F3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22-p21   Ensembl cytogenetic band:  1p21.3   HGNC cytogenetic band: 1p22-p21

F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094994:  view genomic region     (about GC identifiers)

Start:
94,994,732 bp from pter      End:
95,007,413 bp from pter
Size:
12,682 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TF_HUMAN, P13726 (See protein sequence)
Recommended Name: Tissue factor precursor  
Size: 295 amino acids; 33068 Da
Subunit: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X
and activates coagulation in the presence of activated factor VII
Selected PDB 3D structures from and Proteopedia for F3 (see all 42):
1AHW (3D)        1BOY (3D)        1DAN (3D)        1FAK (3D)        1J9C (3D)        1JPS (3D)    
Secondary accessions: D3DT47 Q6FHG2 Q86WH4
Alternative splicing: 2 isoforms:  P13726-1   P13726-2   

Explore the universe of human proteins at neXtProt for F3: NX_P13726

Explore proteomics data for F3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn156, Asn169
  • Modification sites at PhosphoSitePlus

  • See F3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171567.1  NP_001984.1  

    ENSEMBL proteins: 
     ENSP00000334145   ENSP00000359226  
    Reactome Protein details: P13726

    F3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for F3 (Coagulation Factor III/Tissue Factor)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for F3
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for F3
    OriGene Custom Protein Services for F3
    GenScript Custom Purified and Recombinant Proteins Services for F3
    Novus Biologicals F3 Proteins
    Novus Biologicals F3 Lysate
    Sino Biological Recombinant Protein for F3
    Sino Biological Cell Lysate for F3
    ProSpec Recombinant Protein for F3
    Browse Proteins at Cloud-Clone Corp.

    F3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of F3
    R&D Systems Antibodies for F3 (Coagulation Factor III/Tissue Factor)
    OriGene Antibodies for F3
    OriGene Custom Antibody Services for F3
    Novus Biologicals F3 Antibodies
    Abcam antibodies for F3
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for F3
    LSBio Antibodies in human, mouse, rat for F3

    F3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for F3
    R&D Systems ELISAs for F3 (Coagulation Factor III/Tissue Factor)         (see all)
    GenScript Custom Assay Services for F3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    5 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold
     IPR001187 Tissue_factor
     IPR016354 Tissue_fac/coagulation_fac-3

    Graphical View of Domain Structure for InterPro Entry P13726

    ProtoNet protein and cluster: P13726

    1 Blocks protein domain: IPB001187 Tissue factor

    UniProtKB/Swiss-Prot: TF_HUMAN, P13726
    Similarity: Belongs to the tissue factor family


    F3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TF_HUMAN, P13726
    Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa]
    complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by
    initiating the cell-surface assembly and propagation of the coagulation protease cascade
    Induction: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators
    interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a
    component of cellular immune response

         Genatlas biochemistry entry for F3:
    coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI3455766
    GO:0005515protein binding IPI15522303
    GO:0005543phospholipid binding IDA17469850
         
    F3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for F3:
     Increased S DNA content 

         15 MGI mutant phenotypes (inferred from 7 alleles(MGI details for F3):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  normal  tumorigenesis  vision/eye 

    F3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for F3: F3tm1Gjb F3tm1Dco F3tm1Jld F3tm1Dwr F3tm1.1Dwr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for F3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for F3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for F3

    miRNA
    Products:
        
    miRTarBase miRNAs that target F3:
    hsa-mir-375 (MIRT019927), hsa-mir-26b-5p (MIRT029798), hsa-mir-130b-3p (MIRT020315), hsa-mir-93-5p (MIRT028146), hsa-mir-124-3p (MIRT022817)

    Block miRNA regulation of human, mouse, rat F3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate F3 (see all 37):
    hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-223 hsa-miR-1244 hsa-miR-93 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for F3
    Predesigned siRNA for gene silencing in human, mouse, rat F3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for F3

    Clone
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    OriGene clones in human, mouse for F3 (see all 12)
    OriGene ORF clones in mouse, rat for F3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: F3 (NM_001659)
    Sino Biological Human cDNA Clone for F3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for F3
    Browse ESI BIO Cell Lines and PureStem Progenitors for F3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TF_HUMAN, P13726: Isoform 1: Membrane; Single-pass type I membrane protein
    TF_HUMAN, P13726: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    peroxisome3
    plasma membrane3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA19065458
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA17898544
    GO:0016021integral component of membrane IEA--
    GO:0031012extracellular matrix IDA2704749

    F3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for F3 About    
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Extrinsic Prothrombin Activation Pathway0.00
    Blood Coagulation Signaling Pathways0.51
    Extrinsic Pathway0.00
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    3Hemostasis
    Hemostasis0.43
    4NOD-like Receptor Signaling Pathways
    Immune response IL 1 signaling pathway0.42
    5Collagen biosynthesis and modifying enzymes
    Blood Coagulation Cascade0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for F3
        Blood Coagulation Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F3
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade

    1 GeneGo (Thomson Reuters) Pathway for F3
        Immune response IL-1 signaling pathway

    1 BioSystems Pathway for F3
        Complement and Coagulation Cascades


    1 Reactome Pathway for F3
        Extrinsic Pathway


    1 Kegg Pathway  (Kegg details for F3):
        Complement and coagulation cascades


    F3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including F3 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for F3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for F3 (P137263 ENSP000003341454) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F7P087093, ENSP000003647314I2D: score=5 STRING: ENSP00000364731
    FANCBQ8NB913, ENSP000003268194I2D: score=1 STRING: ENSP00000326819
    F10P007423, ENSP000003647094I2D: score=1 STRING: ENSP00000364709
    FLNAP213333, ENSP000003588664I2D: score=2 STRING: ENSP00000358866
    PLGP007473, ENSP000003089384I2D: score=2 STRING: ENSP00000308938
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA17898544
    GO:0002541activation of plasma proteins involved in acute inflammatory response IDA17469850
    GO:0002543activation of blood coagulation via clotting cascade IC17469850
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA17898544
    GO:0007596blood coagulation TAS--

    F3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for F3 (TF)

    4 DrugBank Compounds for F3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coagulation factor VIIaCoagulation factor VII precursor (see all 5)9001-25-6target--6658368 1586032 13713641
    2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE-- --target--10592235
    [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA-- --target--10592235
    {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for F3 gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 91 858 14987914 (4), 16454558 (4), 15795541 (3), 7923650 (3) (see all 99)
    heparin 90.5 923 10235445 (7), 10704648 (6), 15306747 (5), 8630391 (5) (see all 99)
    ecarin 84.7 32 17102656 (2), 7900080 (1), 12643328 (1), 12960616 (1) (see all 30)
    argatroban 84.4 64 11307810 (2), 19719819 (2), 11994559 (1), 15886289 (1) (see all 59)
    hirudin 83.2 81 1658403 (3), 15718352 (3), 16919046 (2), 8409044 (2) (see all 66)
    mnpt 78.6 4 9459336 (2), 10926265 (1), 9059355 (1)
    warfarin 77.2 95 9245222 (3), 10702890 (2), 8503731 (2), 1562730 (2) (see all 67)
    hemochron 76.3 11 19398428 (2), 12533064 (1), 9535388 (1), 17686264 (1) (see all 10)
    ristocetin 71.2 27 10335531 (1), 12185511 (1), 11913569 (1), 12010430 (1) (see all 24)
    d-phe-phe-arg-chloromethyl ketone 68.7 2 11258943 (1), 9819025 (1)



    F3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for F3 gene (2 alternative transcripts): 
    NM_001178096.1  NM_001993.4  

    Unigene Cluster for F3:

    Coagulation factor III (thromboplastin, tissue factor)
    Hs.62192  [show with all ESTs]
    Unigene Representative Sequence: NM_001993
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334047(uc001dqp.2 uc001dqq.2 uc001dqr.3 uc001dqs.3)
    ENST00000370207 ENST00000478217 ENST00000480356(uc001dqt.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat F3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate F3 (see all 37):
    hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-223 hsa-miR-1244 hsa-miR-93 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for F3
    Predesigned siRNA for gene silencing in human, mouse, rat F3
    Clone
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    OriGene clones in human, mouse for F3 (see all 12)
    OriGene ORF clones in mouse, rat for F3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: F3 (NM_001659)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F3
    Primer
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    OriGene qPCR primer pairs and template standards for F3
    OriGene qSTAR qPCR primer pairs in human, mouse for F3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat F3
      QuantiTect SYBR Green Assays in human, mouse, rat F3
      QuantiFast Probe-based Assays in human, mouse, rat F3

    Additional mRNA sequence: 

    AF487337.1 AF497569.1 AF497570.1 AF497571.1 AK310918.1 AK312638.1 AY940729.1 AY940730.1 
    AY940731.1 BC011029.1 BT019808.1 CR541792.1 J02931.1 M16553.1 M27436.1 X07680.1 

    11 DOTS entries:

    DT.413467  DT.91748572  DT.100833527  DT.95258172  DT.100787064  DT.100034264  DT.91657428  DT.100045137 
    DT.91696356  DT.91748574  DT.95250461 

    Selected AceView cDNA sequences (see all 147):

    F06293 CR590388 CA438772 BM988577 X07680 CA437990 AA373308 R46493 
    AW338870 F02583 BM769013 CA307794 BM763298 BM981095 CD677037 BI335812 
    AI573071 BE644908 BP354309 BP352745 AI720113 BX402583 AW381342 CA390109 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for F3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:              -     -     -           -                 -                                       
    SP2:                                      -                 -                                       
    SP3:              -     -     -           -                 -     -                                 
    SP4:                                      -                 -     -                                 
    SP5:                                                                                                


    ECgene alternative splicing isoforms for F3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    F3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAAAGTA
    F3 Expression
    About this image


    F3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Corneal Epithelium
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    F3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    F3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62192

    UniProtKB/Swiss-Prot: TF_HUMAN, P13726
    Tissue specificity: Lung, placenta and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including F3 (see all 8): 
              NFKB Signaling Targets in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Interferons & Receptors in human mouse rat
              Wound Healing in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for F3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F31 , 5 coagulation factor III1, 5 69.54(n)1
    56.83(a)1
      3 (52.94 cM)5
    140661  NM_010171.31  NP_034301.31 
     1217235375 
    chicken
    (Gallus gallus)
    Aves F31 coagulation factor III (thromboplastin, tissue factor) 56.42(n)
    48.52(a)
      429084  XM_426640.2  XP_426640.2 
    lizard
    (Anolis carolinensis)
    Reptilia F36
    coagulation factor III (thromboplastin, tissue fac...
    40(a)
    1 ↔ 1
    4(89102397-89117634)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia f31 coagulation factor III (thromboplastin, tissue factor) 53.19(n)
    44.04(a)
      100489511  XM_002933791.2  XP_002933837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f3a1 coagulation factor IIIa 48.76(n)
    40.8(a)
      567257  NM_001245967.1  NP_001232896.1 


    ENSEMBL Gene Tree for F3 (if available)
    TreeFam Gene Tree for F3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for F3 gene

    F3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for F3
    PGOHUM00000249654


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for F3 (see all 323)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57762241,2
    C--93119445(+) AACCTC/-CAGGC 2 -- int12Minor allele frequency- -:0.39NA CSA 46
    rs23914241,2
    C,F--93119447(-) CTGCCC/G/TGGAGG 2 -- int11NA 48
    rs668557461,2
    C--93119447(+) CCTCC-/AGGCAG 2 -- int10--------
    rs589270221,2
    C--94995630(+) AAAAA-/AAAGCTTT 2 -- cds10--------
    rs665641131,2
    C--94995630(+) GTCTC-/AAAAAAAA 4 -- ut311Minor allele frequency- AAA:0.00NA 2
    rs105370051,2
    C--94996860(+) gtttc-/TTttttt 2 -- int11Minor allele frequency- TT:0.00NA 2
    rs1417049741,2
    C--94996860(+) GTTTC-/TTTTTTT 2 -- int10--------
    rs39176071,2
    C--95004589(-) TAATAT/-TTGAG 2 -- int12Minor allele frequency- -:0.01NS 90
    rs729683561,2
    C--95008532(+) TATCTC/TGTTTA 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs765547071,2
    --95017818(+) GTAGAA/GAGCAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for F3 (94994732 - 95007413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for F3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1899CNV Insertion18451855
    dgv270n71CNV Loss21882294
    nsv871764CNV Loss21882294

    Human Gene Mutation Database (HGMD): F3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing F3
    DNA2.0 Custom Variant and Variant Library Synthesis for F3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134390    OMIM disorders: --

    Selected diseases for F3 (see all 259):    
    About MalaCards
    carotid artery thrombosis    heparin-induced thrombocytopenia    hemophilia b    compton-north congenital myopathy
    multifocal lymphangioendotheliomatosis with thrombocytopenia    factor xii deficiency    mild hemophilia b    disseminated intravascular coagulation
    factor xi deficiency    hemophilia    antiphospholipid syndrome    hemorrhagic disease
    prothrombin deficiency    hantavirus pulmonary syndrome    acquired hemophilia    factor xiii deficiency
    sagittal sinus thrombosis    factor vii deficiency    factor x deficiency    acute fatty liver of pregnancy

    Selected diseases from the University of Copenhagen DISEASES database for F3 (see all 23):
    Disseminated intravascular coagulation     Thrombocytopenia     Vascular disease     Antiphospholipid syndrome
    Heart disease     Lupus erythematosus     Factor VII deficiency     Factor XI deficiency
    Hemophilia B     Factor XII deficiency     Von Willebrand's disease     Brain disease
    Cancer     Liver disease     Factor X deficiency     Vitamin K deficiency hemorrhagic disease
    Connective tissue disease     Respiratory failure     Factor VIII deficiency     Kidney failure

    F3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for F3 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    partial thromboplastin time prolonged 91.4 84 9084708 (3), 12972821 (3), 2301750 (1), 2110553 (1) (see all 78)
    coagulopathy 89.1 128 8192064 (2), 8725725 (2), 19901655 (2), 18687038 (2) (see all 99)
    thrombosis 85.5 272 8911269 (4), 16466951 (4), 18610631 (3), 17694958 (3) (see all 99)
    bleeding 85.5 457 9031451 (4), 10934288 (4), 10389296 (3), 1625090 (3) (see all 99)
    disseminated intravascular coagulation 84.1 68 16828603 (2), 14758173 (2), 8180381 (1), 8037186 (1) (see all 61)
    apc resistance 81 49 11119756 (1), 11583314 (1), 11816542 (1), 15947551 (1) (see all 45)
    pt prolonged 80.9 8 8826562 (1), 8503731 (1), 17393015 (1), 7841574 (1) (see all 8)
    thrombophilia 80.7 51 12028043 (3), 16479463 (2), 15617024 (2), 7479207 (1) (see all 45)
    antiphospholipid syndrome 77 37 8911269 (3), 7479207 (1), 9522600 (1), 12652293 (1) (see all 32)
    thrombocytopenia 77 91 7634703 (1), 7489960 (1), 8826562 (1), 8882480 (1) (see all 90)

    Genetic Association Database (GAD): F3
    Human Genome Epidemiology (HuGE) Navigator: F3 (44 documents)

    Export disorders for F3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for F3 gene, integrated from 10 sources (see all 3174):
    (articles sorted by number of sources associating them with F3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tissue factor +5466A&gt;G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. (PubMed id 19027114)1, 4, 9 Undas A....Tracz W. (Atherosclerosis 2009)
    2. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)1, 2, 9 Eisenreich A.... Rauch U. (Circ. Res. 2009)
    3. Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PubMed id 16239598)1, 4, 9 MAolarstig A....Siegbahn A. (Arterioscler. Thromb. Vasc. Biol. 2005)
    4. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. (PubMed id 12652293)1, 2, 9 Bogdanov V.Y....Nemerson Y. (Nat. Med. 2003)
    5. A genome-wide association search for type 2 diabetes genes in African Americans. (PubMed id 22238593)1, 4 Palmer N.D....Sladek R. (PLoS ONE 2012)
    6. Genetic predictors of fibrin D-dimer levels in healthy adults. (PubMed id 21502573)1, 4 Smith N.L....Hayward C. (Circulation 2011)
    7. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    10. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2152 HGNC: 3541 AceView: F3 Ensembl:ENSG00000117525 euGenes: HUgn2152
    ECgene: F3 Kegg: 2152 H-InvDB: F3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for F3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for F3 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/f3/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF
    Wikipedia http://en.wikipedia.org/wiki/Tissue_factor

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for F3 gene:
    Search GeneIP for patents involving F3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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