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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

F3 Gene

protein-coding GIFtS: 68
GCID: GC01M094994

coagulation factor III (thromboplastin, tissue factor)

Explore 281 diseases affiliated with
F3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coagulation Factor III (Thromboplastin, Tissue Factor)¹ ²		Tissue Factor²
CD142¹ ²		Thromboplastin³
TF² ³		CD142 Antigen³
TFA² ⁵		Coagulation Factor III³

External Ids:	HGNC: 3541¹	Entrez Gene: 2152²	Ensembl: ENSG00000117525⁷	OMIM: 134390⁵	UniProtKB: P13726³

Export aliases for F3 gene to outside databases

Previous GC identifers: GC01M095396 GC01M094200 GC01M094345 GC01M094466 GC01M094706 GC01M093116

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F3:

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate

the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The

resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades

by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as

nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces.

There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only

one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in

multiple transcript variants.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex

activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the

cell-surface assembly and propagation of the coagulation protease cascade

Gene Wiki entry for F3 (Tissue factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the F3 gene promoter:
AREB6 Tal-1 Pax-5 MyoD STAT3 E47 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): F3 promoter sequence

Search SABiosciences Chromatin IP Primers for F3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22-p21 Ensembl cytogenetic band: 1p21.3 HGNC cytogenetic band: 1p22-p21

F3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M094994: view genomic region (about GC identifiers)

Start:	94,994,732 bp from pter	End:	95,007,413 bp from pter
Size:	12,682 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TF_HUMAN, P13726 (See protein sequence)

Recommended Name: Tissue factor precursor

Size: 295 amino acids; 33068 Da

Subunit: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and

activates coagulation in the presence of activated factor VII

Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

6/42 PDB 3D structures from and Proteopedia for F3 (see all 42):

1AHW (3D)

1BOY (3D)

1DAN (3D)

1FAK (3D)

1J9C (3D)

1JPS (3D)

Secondary accessions: D3DT47 Q6FHG2 Q86WH4

Alternative splicing: 2 isoforms: P13726-1 P13726-2

Explore the universe of human proteins at neXtProt for F3: NX_P13726

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13726

F3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171567.1 NP_001984.1

ENSEMBL proteins:

ENSP00000334145 ENSP00000359226

Reactome Protein details: P13726
Human Recombinant Protein Products:

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	Uscn Proteins for F3

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	19065458
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	TAS	--
GO:0009986	cell surface	--	--
GO:0016021	integral to membrane	IEA	--

F3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for F3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

F3 for domains About GeneDecksing

5 InterPro domains/families:

IPR003961 Fibronectin_type3

IPR015373 Interferon_alpha/beta_rcpt_bsu

IPR013783 Ig-like_fold

IPR001187 Tissue_factor

IPR016354 Tissue_fac/coagulation_fac-3

Graphical View of Domain Structure for InterPro Entry P13726

ProtoNet protein and cluster: P13726

1 Blocks protein family: IPB001187 Tissue factor

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Similarity: Belongs to the tissue factor family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex

activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the

cell-surface assembly and propagation of the coagulation protease cascade

Induction: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators

interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a

component of cellular immune response

Genatlas biochemistry entry for F3:

coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7

miRNA Products:		OriGene 3'-UTR Clone: F3 Browse MicroRNA Expression Plasmids
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		hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-223 hsa-miR-1244 hsa-miR-93 hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: F3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	3455766
GO:0005515	protein binding	IPI	--
GO:0005543	phospholipid binding	IDA	17469850
GO:0043498	cell surface binding	IDA	17898544

F3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for F3:

Increased S DNA content

Animal Models:
Mouse knock-outs for F3: F3^tm1Gjb F3^tm1Dco F3^tm1Jld F3^tm1Dwr F3^tm1.1Dwr
15 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for F3):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	mortality/aging
muscle	nervous system	normal	tumorigenesis	vision/eye

F3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of Fibrin Clot (Clotting Cascade)

Formation of Fibrin Clot (Clotting Cascade)

1.00

Blood Coagulation Signaling Pathways

0.51

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Complement and Coagulation Cascades

0.72

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Common Pathway

Extrinsic Prothrombin Activation Pathway

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for F3

Immune response IL-1 signaling pathway

1 R&D Systems Pathway for F3

Blood Coagulation Signaling Pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F3

	Extrinsic Prothrombin Activation Pathway
	Blood Coagulation Cascade

1 GeneGo (Thomson Reuters) Pathway for F3

Immune response IL-1 signaling pathway

1 BioSystems Pathway for F3

Complement and Coagulation Cascades

3 Reactome Pathways for F3

	Hemostasis
	Extrinsic Pathway
	Formation of Fibrin Clot (Clotting Cascade)

1 Kegg Pathway (Kegg details for F3):

Complement and coagulation cascades

F3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for F3

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/15 Interacting proteins for F3 (P13726³ ENSP00000334145⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F7	P08709³, ENSP00000364731⁴	I2D: score=5 STRING: ENSP00000364731
FANCB	Q8NB91³, ENSP00000326819⁴	I2D: score=1 STRING: ENSP00000326819
F10	P00742³, ENSP00000364709⁴	I2D: score=1 STRING: ENSP00000364709
FLNA	P21333³, ENSP00000358866⁴	I2D: score=2 STRING: ENSP00000358866
PLG	P00747³, ENSP00000308938⁴	I2D: score=2 STRING: ENSP00000308938

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001938	positive regulation of endothelial cell proliferation	IDA	17898544
GO:0002541	activation of plasma proteins involved in acute inflammatory response	IDA	17469850
GO:0002543	activation of blood coagulation via clotting cascade	IC	17469850
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	17898544
GO:0007568	aging	--	--

F3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

F3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for F3

4 DrugBank Compounds for F3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Coagulation factor VIIa	Coagulation factor VII precursor (see all 5)	9001-25-6	target	--	6658368 1586032 13713641
2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE	--	--	target	--	10592235
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA	--	--	target	--	10592235
{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID	--	--	target	--	10592235

10/134 Novoseek chemical compound relationships for F3 gene (see all 134) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrinogen	91	858	14987914 (4), 16454558 (4), 15795541 (3), 7923650 (3) (see all 99)
heparin	90.5	923	10235445 (7), 10704648 (6), 15306747 (5), 8630391 (5) (see all 99)
ecarin	84.7	32	17102656 (2), 7900080 (1), 12643328 (1), 12960616 (1) (see all 30)
argatroban	84.4	64	11307810 (2), 19719819 (2), 11994559 (1), 15886289 (1) (see all 59)
hirudin	83.2	81	1658403 (3), 15718352 (3), 16919046 (2), 8409044 (2) (see all 66)
mnpt	78.6	4	9459336 (2), 10926265 (1), 9059355 (1)
warfarin	77.2	95	9245222 (3), 10702890 (2), 8503731 (2), 1562730 (2) (see all 67)
hemochron	76.3	11	19398428 (2), 12533064 (1), 9535388 (1), 17686264 (1) (see all 10)
ristocetin	71.2	27	10335531 (1), 12185511 (1), 11913569 (1), 12010430 (1) (see all 24)
d-phe-phe-arg-chloromethyl ketone	68.7	2	11258943 (1), 9819025 (1)

Search CenterWatch for drugs/clinical trials and news about F3 / TF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for F3 gene (2 alternative transcripts):

NM_001178096.1 NM_001993.4

Unigene Cluster for F3:

Coagulation factor III (thromboplastin, tissue factor)

Hs.62192 [show with all ESTs]

Unigene Representative Sequence: NM_001993

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000334047(uc001dqp.2 uc001dqq.2 uc001dqr.3 uc001dqs.3)

ENST00000370207 ENST00000478217 ENST00000480356(uc001dqt.3)

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		hsa-miR-300 hsa-miR-106a hsa-miR-605 hsa-miR-128 hsa-miR-223 hsa-miR-1244 hsa-miR-93 hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: F3 3' UTR sequence

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Additional cDNA sequence:

AF487337.1 AF497569.1 AF497570.1 AF497571.1 AK310918.1 AK312638.1 AY940729.1 AY940730.1

AY940731.1 BC011029.1 BT019808.1 CR541792.1 J02931.1 M16553.1 M27436.1 X07680.1

11 DOTS entries:

DT.413467 DT.91748572 DT.100833527 DT.95258172 DT.100787064 DT.100034264 DT.91657428 DT.100045137

DT.91696356 DT.91748574 DT.95250461

24/147 AceView cDNA sequences (see all 147):

BM769013 R46493 CA438772 CD677037 BI335812 BM988577 CA437990 X07680

AI573071 AW338870 CR590388 F06293 CA307794 F02583 BM763298 AA373308

BM981095 BG681474 BP355632 BI913529 BP353346 BP356096 AL133885 AF487337

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for F3 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:					-		-		-				-						-
SP2:													-						-
SP3:					-		-		-				-						-		-
SP4:													-						-		-
SP5:

ECgene alternative splicing isoforms for F3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

F3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGAAAGTA

About this image

F3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Amacrine, Retina

Midgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See F3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for F3

SOURCE GeneReport for Unigene cluster: Hs.62192

UniProtKB/Swiss-Prot: TF_HUMAN, P13726

Tissue specificity: Lung, placenta and pancreas

SABiosciences Expression via Pathway-Focused PCR Arrays including F3 (see all 8):

NFKB Signaling Targets in human mouse rat

Endothelial Cell Biology in human mouse rat

Interferons & Receptors in human mouse rat

Wound Healing in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for F3 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	F3^{1 , 5}	coagulation factor III^{1, 5}	69.42(n)¹ 56.83(a)¹		3 (52.94 cM)⁵ 14066¹ NM_010171.3¹ NP_034301.3¹ 121723537⁵
chicken (Gallus gallus)	Aves	F3¹	coagulation factor III (thromboplastin, tissue factor)	55.64(n) 47.47(a)		429084 XM_426640.1 XP_426640.1
lizard (Anolis carolinensis)	Reptilia	F3⁶	--	40(a)	1 ↔ 1	4(89104403-89111719)
zebrafish (Danio rerio)	Actinopterygii	f3b¹	coagulation factor IIIb	49.63(n) 38.76(a)		550423 NM_001017728.1 NP_001017728.1

ENSEMBL Gene Tree for F3 (if available)
TreeFam Gene Tree for F3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for F3 gene

F3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for F3
PGOHUM00000249654

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76554707^1,2		--	93116130(+)	`GTAGAA/GAGCAT`	2	--	ds500¹		0	--	--	--	--
rs80054225^1,2	F,	--	93116322(+)	`TTGCCG/AGTTTC`	2	--	ds500¹		2		NA EA	240
rs3917637^1,2	C,F,	--	93116454(-)	`TTTTCG/TCTTAT`	2	--	ut3¹		3		NS WA	212
rs3917636^1,2	C,H,	--	93116484(-)	`AAATTG/TTCAGT`	2	--	ut3¹		7		NS EA WA	612
rs3917635^1,2	C,F,H,	--	93116789(-)	`TAAACA/GTTTGA`	2	--	ut3¹		12		NS EA NA WA	1278
rs3917634^1,2	F	--	93117279(-)	`gatctC/Tggctc`	2	--	ut3¹		2		NS	90
rs79143762^1,2	C,	--	93117410(+)	`TTGGAC/TGACCT`	2	--	ut3¹		1		NA	2
rs3917632^1,2	C,F,H,	--	93117475(-)	`AACACC/TATGGC`	2	--	ut3¹ ese³		13		NS NA WA	1238
rs41439746^1,2	C,	--	93117633(-)	`GGAAAC/TGCAAA`	2	--	ut3¹		2		NA	50
rs3917630^1,2	C,F,H,	--	93118219(-)	`AATCCT/GGGTAG`	2	--	int¹		7		NS EA WA	600

HapMap Linkage Disequilibrium report for F3 (94994732 - 95007413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for F3: --
Human Gene Mutation Database (HGMD): F3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing F3

DNA2.0 Custom Variant and Variant Library Synthesis for F3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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F3 for disorders           About GeneDecksing

OMIM gene information: 134390    OMIM disorders: --

20/281 diseases for F3 (see all 281):    About MalaCards

crimean-congo hemorrhagic fever factor xiii deficiency factor xi deficiency disseminated intravascular coagulation

factor xii deficiency factor vii deficiency heparin-induced thrombocytopenia deep vein thrombosis

rosai-dorfman disease vitamin k deficiency hemorrhagic disease splenic marginal zone lymphoma ruptured abdominal aortic aneurysm

glanzmann's thrombasthenia carotid artery thrombosis von willebrand's disease acquired von willebrand syndrome

factor x deficiency abdominal aortic aneurysm sagittal sinus thrombosis arterial occlusive disease

20/22 diseases from the University of Copenhagen DISEASES database for F3 (see all 22):

Disseminated intravascular coagulation Thrombocytopenia Vascular disease Antiphospholipid syndrome

Heart disease Lupus erythematosus Factor VII deficiency Factor XI deficiency

Hemophilia B Factor XII deficiency Von Willebrand's disease Brain disease

Liver disease Cancer Vitamin K deficiency hemorrhagic disease Factor X deficiency

Connective tissue disease Factor VIII deficiency Respiratory failure Kidney failure

10/96 Novoseek disease relationships for F3 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
partial thromboplastin time prolonged	91.4	84	9084708 (3), 12972821 (3), 2301750 (1), 2110553 (1) (see all 78)
coagulopathy	89.1	128	8192064 (2), 8725725 (2), 19901655 (2), 18687038 (2) (see all 99)
thrombosis	85.5	272	8911269 (4), 16466951 (4), 18610631 (3), 17694958 (3) (see all 99)
bleeding	85.5	457	9031451 (4), 10934288 (4), 10389296 (3), 1625090 (3) (see all 99)
disseminated intravascular coagulation	84.1	68	16828603 (2), 14758173 (2), 8180381 (1), 8037186 (1) (see all 61)
apc resistance	81	49	11119756 (1), 11583314 (1), 11816542 (1), 15947551 (1) (see all 45)
pt prolonged	80.9	8	8826562 (1), 8503731 (1), 17393015 (1), 7841574 (1) (see all 8)
thrombophilia	80.7	51	12028043 (3), 16479463 (2), 15617024 (2), 7479207 (1) (see all 45)
antiphospholipid syndrome	77	37	8911269 (3), 7479207 (1), 9522600 (1), 12652293 (1) (see all 32)
thrombocytopenia	77	91	7634703 (1), 7489960 (1), 8826562 (1), 8882480 (1) (see all 90)

Genetic Association Database (GAD): F3
Human Genome Epidemiology (HuGE) Navigator: F3 (44 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for F3 gene, integrated from 9 sources (see all 3136):
(articles sorted by number of sources associating them with F3)

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Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PubMed id 19168442)^{1, 2, 9} Eisenreich A....Rauch U. (2009)
Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PubMed id 16239598)^{1, 4, 9} Malarstig A....Siegbahn A. (2005)
Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. (PubMed id 12652293)^{1, 2, 9} Bogdanov V.Y....Nemerson Y. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Genetic factors contribute to bleeding after cardiac surgery. (PubMed id 15892865)^{1, 4} Welsby I.J....Stafford-Smith M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant. (PubMed id 9925787)^{1, 2} Zhang E.... Tulinsky A. (1999)
The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution. (PubMed id 8609606)^{1, 2} Muller Y.A.... de Vos A.M. (1996)
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. (PubMed id 8598903)^{1, 2} Banner D.W.... Kirchhofer D. (1996)
Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. (PubMed id 8086403)^{1, 2} Muller Y.A.... de Vos A.M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2152	HGNC: 3541	AceView: F3	Ensembl:ENSG00000117525	euGenes: HUgn2152
ECgene: F3	Kegg: 2152	H-InvDB: F3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for F3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for F3	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/f3/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TF
Wikipedia	http://en.wikipedia.org/wiki/Tissue_factor

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Patent Information for F3 gene:
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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F3 Gene

coagulation factor III (thromboplastin, tissue factor)

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PT PROLONGED
Pregnancy loss
Hemorrhagic diseases
Fetal Resorption
ABNORMAL PLATELETS
sepsis
Anemia Hemolytic
coagulopathy
Acute myocardial infarction
GASTROINTESTINAL BLEEDING
Factor VII Deficiency
Purpura Thrombotic Thrombocytopenic
Liver diseases
Atherosclerosis
Antiphospholipid Syndrome
Hematoma Subdural
Deep vein thrombosis
Hypofibrinogenemia
Factor XIII Deficiency
cell damage
Hemolysis
Thrombocytopenia
CLOTTING TIME INCREASED
Coagulation Factor Deficiency
GINGIVAL BLEEDING
Uterine Bleeding
Petechiae
Cerebral Thrombosis
Miscarriage
Cerebral Infarction
PARTIAL THROMBOPLASTIN TIME PROLONGED
ARTERIAL THROMBOSIS
Liver Failure
Factor XII Deficiency
Inflammation
Coronary Thrombosis
Monocytic leukemia
THROMBOSIS MURAL
Melena
Intracerebral Hemorrhage
Renal Failure
Cardiovascular Diseases
Tumors
Thrombosis
Metastasis
Necrosis
Disseminated Intravascular Coagulation
Preeclampsia
Shock Septic
Thrombocytosis
Cirrhosis
APC Resistance
Critically Ill
Venous Thrombosis
Hematoma Epidural
atherosclerotic plaque
Carotid Artery Thrombosis
Systemic Inflammatory Response Syndrome
INFARCT
Factor X Deficiency
Ecchymosis
Leukopenia
Arterial Occlusive Diseases
Miscarriage Recurrent
hypoalbuminemia
BLEEDING TENDENCY
Intracranial Hemorrhages
Factor XI Deficiency
Inherited Coagulation Disorders
Myocardial Infarction
Multiple Organ Failure
Coronary Artery Disease
von Willebrand Disease
Protein S Deficiency
stasis
Liver Dysfunction
Hemophilia A
Bleeding
Coronary atheroma
Afibrinogenemia
Menorrhagia
Leukemia Promyelocytic Acute
Glanzmann Thrombasthenia
Hematoma
Blood Loss Postoperative
Thrombophilia
STROKE
PROLONGED BLEEDING TIME
FUNCTION LIVER ABNORMAL
Hemophilia B
Vascular Diseases
Pulmonary Embolism
platelet dysfunction
Pregnancy Complications
Lupus Erythematosus Systemic
Thromboembolism

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F3 Gene

coagulation factor III (thromboplastin, tissue factor)

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