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F2RL3 Gene

protein-coding   GIFtS: 64
GCID: GC19P017898

Coagulation Factor II (Thrombin) Receptor-Like 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coagulation Factor II (Thrombin) Receptor-Like 31 2     Proteinase-Activated Receptor-41
PAR42 3 5     Protease-Activated Receptor-42
Thrombin Receptor-Like 32 3     Proteinase-Activated Receptor 42
PAR-42 3     Coagulation Factor II Receptor-Like 33

External Ids:    HGNC: 35401   Entrez Gene: 90022   Ensembl: ENSG000001275337   OMIM: 6027795   UniProtKB: Q96RI03   

Export aliases for F2RL3 gene to outside databases

Previous GC identifers: GC19P017493 GC19P017392 GC19P016845 GC19P016860 GC19P017000 GC19P016568 GC19P017001 GC19P017109 GC19P017365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for F2RL3 Gene:
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region
receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated
receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino
terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
(provided by RefSeq, Jul 2008)

GeneCards Summary for F2RL3 Gene:
F2RL3 (coagulation factor II (thrombin) receptor-like 3) is a protein-coding gene. GO annotations related to this gene include thrombin receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide
hydrolysis. May play a role in platelets activation

summary for F2RL3 Gene:
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors,
activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide
ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling.
Four subtypes of receptors have so far been cloned (PAR1-4). PAR4 tissue distribution is different from
other PAR family members, with highest levels detected in the lung, pancreas, thyroid and testes. This
receptor is localized to human chromosome 19p12. PAR4 is sensitive to both alpha- and gamma-thrombin, yet
has a low affinity for the peptide. PAR4 therefore may function as a low affinity thrombin receptor that is
activated at conditions where high concentrations of thrombin are achieved. This receptor helps to sustain
platelet aggregation during prolonged thrombin exposure, as unlike PAR1, it is slowly inactivated.

Gene Wiki entry for F2RL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the F2RL3 gene promoter:
         GR   C/EBPbeta   CUTL1   E47   E2F-1   E2F   COMP1   STAT3   GR-alpha   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF2RL3 promoter sequence
   Search Chromatin IP Primers for F2RL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F2RL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p12

F2RL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2RL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017898:  view genomic region     (about GC identifiers)

Start:
16,999,671 bp from pter      End:
17,003,417 bp from pter
Size:
3,747 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0 (See protein sequence)
Recommended Name: Proteinase-activated receptor 4 precursor  
Size: 385 amino acids; 41133 Da
2 PDB 3D structures from and Proteopedia for F2RL3:
2ZPK (3D)        3QDZ (3D)    
Secondary accessions: O76067 Q6DK42

Explore the universe of human proteins at neXtProt for F2RL3: NX_Q96RI0

Explore proteomics data for F2RL3 at MOPED

Post-translational modifications: 

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand1
  • Glycosylation2 at Asn56
  • Modification sites at PhosphoSitePlus

  • See F2RL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003941.2  
    ENSEMBL proteins: 
     ENSP00000248076   ENSP00000471518  
    Reactome Protein details: Q96RI0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    F2R: GPCR / Class A : Protease activated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAR4
    Protease-activated receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003912 Protea_act_rcpt
     IPR003944 Prot_act_rcpt_4
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96RI0

    ProtoNet protein and cluster: Q96RI0

    2 Blocks protein domains:
    IPB003912 Protease activated receptor precursor signature
    IPB003944 Protease activated receptor 2 precursor signature


    UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with F2RL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR4_HUMAN, Q96RI0
    Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide
    hydrolysis. May play a role in platelets activation

         Genatlas biochemistry entry for F2RL3:
    proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein coupled
    receptor superfamily,activated by thrombin or trypsin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0015057thrombin receptor activity IEA--
         
    Find genes that share ontologies with F2RL3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for F2RL3:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for F2rl3):
     homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with F2RL3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for F2RL3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAR4_HUMAN, Q96RI0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9618465
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with F2RL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for F2RL3 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5ADP signalling through P2Y purinoceptor 12
    Thrombin signalling through proteinase activated receptors (PARs)0.69


    Find genes that share SuperPaths with F2RL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F2RL3
        G12-G13 in Cellular Signaling
    JAK-STAT Pathway
    Thrombin Signaling

    1 GeneGo (Thomson Reuters) Pathway for F2RL3
        Cell adhesion Integrin inside-out signaling

    1 BioSystems Pathway for F2RL3
        GPCRs, Class A Rhodopsin-like

    3 Reactome Pathways for F2RL3
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    Thrombin signalling through proteinase activated receptors (PARs)

    1 PharmGKB Pathway for F2RL3
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for F2RL3):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including F2RL3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for F2RL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for F2RL3 (Q96RI03 ENSP000002480764) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    F2RL2O002543, ENSP000002966414I2D: score=1 STRING: ENSP00000296641
    EGR2P111613, ENSP000002424804I2D: score=1 STRING: ENSP00000242480
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    ARRB1ENSP000003771414STRING: ENSP00000377141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10702240
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS9618465
    GO:0007596blood coagulation TAS--
    GO:0009611response to wounding TAS9618465

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Compounds for F2RL3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist [245520-69-8]
    SLIGKV-NH2PAR2 receptor agonist[190383-13-2]
    TFLLR-NH2PAR1-activating peptide[197794-83-5]
    2-Furoyl-LIGRLO-amidePotent and selective PAR2 agonist[729589-58-6]
    TRAP-6PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist[141136-83-6]

    3 IUPHAR Ligands for F2RL3 (PAR4)    About this table
    LigandTypeActionAffinityPubmed IDs
    GYPGKF-NH2
    AgonistFull agonist--
    GYPGQV-NH2
    AgonistFull agonist--
    AYPGKF-NH2
    AgonistFull agonist--

    Selected Novoseek inferred chemical compound relationships for F2RL3 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 53.1 2 19954432 (1), 10908720 (1)
    adp 52 17 12871418 (4), 15078882 (3), 12008957 (2), 10820018 (2) (see all 9)
    hirudin 50.3 1 15118533 (1)
    calcium 43.3 40 16939417 (4), 10664248 (2), 17525299 (2), 19437337 (2) (see all 17)
    fibrinogen 38.7 3 19954432 (1), 17200114 (1), 11986217 (1)
    thromboxane 33.7 11 12006403 (5), 12888878 (3), 17988878 (1)
    sb 203580 30.4 1 15923365 (1)
    cytochalasin d 21.6 4 16702038 (4)
    pge2 12.6 1 11907122 (1)
    epinephrine 8.12 2 16420577 (1), 18480058 (1)



    Find genes that share compounds with F2RL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for F2RL3 gene: 
    NM_003950.2  

    Unigene Cluster for F2RL3:

    Coagulation factor II (thrombin) receptor-like 3
    Hs.137574  [show with all ESTs]
    Unigene Representative Sequence: AF055917
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248076(uc002nfa.3) ENST00000599210
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    Additional mRNA sequence: 

    AF055917.1 AF080214.1 AY431102.1 BC074782.2 

    1 DOTS entry:

    DT.75100765 

    15 AceView cDNA sequences:

    BC074782 AW206493 AY431102 BQ286510 AW207357 NM_003950 AW138148 AF080214 
    AF055917 BQ269855 AW104737 AI739295 AI344017 BG142112 AW168359 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    F2RL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCGGCAGA
    F2RL3 Expression
    About this image


    F2RL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Liver (Hepatobiliary System)
             Liver Lobule
    F2RL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    F2RL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.137574

    UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
    Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine.
    Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets

        Pathway & Disease-focused RT2 Profiler PCR Array including F2RL3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for F2RL3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F2rl31 , 5 coagulation factor II (thrombin) receptor-like 31, 5 77.07(n)1
    78.31(a)1
      8 (35.08 cM)5
    140651  NM_007975.31  NP_032001.21 
     727618805 
    chicken
    (Gallus gallus)
    Aves F2RL36
    coagulation factor II (thrombin) receptor-like 3
    45(a)
    1 ↔ 1
    28(4018403-4021126)
    zebrafish
    (Danio rerio)
    Actinopterygii F2RL36
    coagulation factor II (thrombin) receptor-like 3
    36(a)
    1 ↔ 1
    14(38190797-38196952) ENSDARG00000079399


    ENSEMBL Gene Tree for F2RL3 (if available)
    TreeFam Gene Tree for F2RL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for F2RL3 gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  F2RL22  
    GPR422  GPR1322  FFAR12  F2R2  
    7 SIMAP similar genes for F2RL3 using alignment to 2 protein entries:     PAR4_HUMAN (see all proteins):
    F2RL2    F2RL1    P2RY8    F2R    CYSLTR2    KPG_011
    P2RY6

    Find genes that share paralogs with F2RL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for F2RL3 (see all 186)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486660241,2
    --16930607(+) CACCAC/TGTTGG 1 -- us2k10--------
    rs1860800171,2
    --16930675(+) TGGGAA/TTACAG 1 -- us2k10--------
    rs1896166451,2
    C--16930738(+) AACCAC/TCCTGC 1 -- us2k10--------
    rs7739071,2
    C,F--16930755(-) AGTCCG/AGTGAT 1 -- us2k115Minor allele frequency- A:0.49NA EA WA CSA 734
    rs1412944981,2
    C--16930847(+) TTTCCA/GTGTGC 1 -- us2k10--------
    rs356375621,2
    C,F--16930856(+) GCTGAG/AGGTGT 1 -- us2k15Minor allele frequency- A:0.06NA WA 244
    rs796939471,2
    C,F--16930951(+) GGGCCT/CCTGAG 1 -- us2k13Minor allele frequency- C:0.07WA NA EA 358
    rs118797831,2
    C,F,H--16930973(+) GCTAGA/CCTCTC 1 -- us2k17Minor allele frequency- C:0.18NA WA CSA 129
    rs1819511121,2
    --16931059(+) GATCCA/CCGAGT 1 -- us2k10--------
    rs1507698031,2
    --16931062(+) CCCCGA/GGTGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for F2RL3 (16999671 - 17003417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for F2RL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666431CNV Deletion23128226
    dgv3755n71CNV Loss21882294
    nsv911170CNV Loss21882294
    nsv911169CNV Loss21882294
    nsv911174CNV Loss21882294
    nsv911172CNV Loss21882294
    nsv911168CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602779    OMIM disorders: --


    Find genes that share disorders with F2RL3           About GenesLikeMe

    9 Novoseek inferred disease relationships for F2RL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 42.9 4 16952995 (1), 17151288 (1), 12384423 (1)
    inflammation 34.5 5 15451771 (1), 10702240 (1), 14637278 (1), 11440983 (1)
    restenosis 29.9 1 16952995 (1)
    astrocytoma 6.74 3 10664248 (2)
    bleeding 0 2 12008957 (1), 14607253 (1)
    necrosis 0 1 11440983 (1)
    hepatocellular carcinoma 0 2 17323377 (1), 19360302 (1)
    tumors 0 2 17433115 (1), 11440983 (1)
    edema 0 1 15451771 (1)

    Genetic Association Database (GAD): F2RL3
    Human Genome Epidemiology (HuGE) Navigator: F2RL3 (5 documents)

    Export disorders for F2RL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for F2RL3 gene, integrated from 10 sources (see all 178):
    (articles sorted by number of sources associating them with F2RL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human protease-activated receptor 4. (PubMed id 9618465)1, 2, 3, 9 Xu W.-F.... Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 2, 9 Kahn M.L....Coughlin S.R. (J. Clin. Invest. 1999)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)1, 2 Kahn M.L.... Coughlin S.R. (J. Biol. Chem. 1998)
    6. A dual thrombin receptor system for platelet activation. (PubMed id 9716134)1, 2 Kahn M.L.... Coughlin S.R. (Nature 1998)
    7. The role of PAR4 in thrombin-induced thromboxane production in human platelets. (PubMed id 12888878)1, 9 Wu C.C....Teng C.M. (Thromb. Haemost. 2003)
    8. Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1. (PubMed id 19053259)1, 9 Nieman M.T. (Biochemistry 2008)
    9. Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. (PubMed id 12871418)1, 9 Adam F....Jandrot-Perrus M. (J. Thromb. Haemost. 2003)
    10. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. (PubMed id 11907122)1, 9 Asokananthan N....Stewart G.A. (J. Immunol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9002 HGNC: 3540 AceView: F2RL3 Ensembl:ENSG00000127533 euGenes: HUgn9002
    ECgene: F2RL3 Kegg: 9002 H-InvDB: F2RL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for F2RL3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/f2rl3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for F2RL3 gene:
    Search GeneIP for patents involving F2RL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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