Free for academic non-profit institutions. Other users need a Commercial license

Aliases for F2RL3 Gene

Aliases for F2RL3 Gene

  • F2R Like Thrombin/Trypsin Receptor 3 2 3 5
  • Coagulation Factor II (Thrombin) Receptor-Like 3 2 3
  • Thrombin Receptor-Like 3 3 4
  • PAR-4 3 4
  • PAR4 3 4
  • Coagulation Factor II Receptor-Like 3 4
  • Proteinase-Activated Receptor-4 2
  • Proteinase-Activated Receptor 4 3
  • Protease-Activated Receptor-4 3

External Ids for F2RL3 Gene

Previous GeneCards Identifiers for F2RL3 Gene

  • GC19P017493
  • GC19P017392
  • GC19P016845
  • GC19P016860
  • GC19P017000
  • GC19P016568
  • GC19P017001
  • GC19P017109
  • GC19P017365
  • GC19P017898

Summaries for F2RL3 Gene

Entrez Gene Summary for F2RL3 Gene

  • This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

GeneCards Summary for F2RL3 Gene

F2RL3 (F2R Like Thrombin/Trypsin Receptor 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.

UniProtKB/Swiss-Prot for F2RL3 Gene

  • Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Tocris Summary for F2RL3 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2RL3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL3 Gene

Genomics for F2RL3 Gene

Regulatory Elements for F2RL3 Gene

Enhancers for F2RL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F017225 1.2 ENCODE 11.1 +338.0 337954 2.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 OCEL1 ENSG00000269578 MVB12A PLVAP C19orf44 ENSG00000268087 COLGALT1 SMIM7 PGLS F2RL3
GH19F017156 1.1 ENCODE 11.1 +267.9 267927 1.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 ZNF143 PLVAP ENSG00000269044 ENSG00000269578 F2RL3 ANO8 SIN3B ENSG00000268087 MVB12A ENSG00000269815 OCEL1
GH19F017264 1.1 ENCODE 11.1 +377.8 377771 4.8 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207 PLVAP ENSG00000269044 ENSG00000269578 ABHD8 BABAM1 F2RL3 SIN3B OCEL1 ENSG00000269815 ENSG00000268087
GH19F017762 0.9 ENCODE 11.1 +873.9 873851 1.1 YBX3 HDGF HDAC1 ATF1 PKNOX1 SIN3A BMI1 ZNF2 RFX5 ZNF335 MAP1S B3GNT3 INSL3 PLVAP NXNL1 F2RL3 GC19M017755 GC19P019215
GH19F016863 0.4 Ensembl 12.2 -25.6 -25560 0.6 ZBTB40 SIN3B F2RL3 GC19M016869 ENSG00000268743
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around F2RL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for F2RL3 Gene

Chromosome:
19
Start:
16,888,860 bp from pter
End:
16,892,606 bp from pter
Size:
3,747 bases
Orientation:
Plus strand

Genomic View for F2RL3 Gene

Genes around F2RL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2RL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2RL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL3 Gene

Proteins for F2RL3 Gene

  • Protein details for F2RL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RI0-PAR4_HUMAN
    Recommended name:
    Proteinase-activated receptor 4
    Protein Accession:
    Q96RI0
    Secondary Accessions:
    • O76067
    • Q6DK42

    Protein attributes for F2RL3 Gene

    Size:
    385 amino acids
    Molecular mass:
    41133 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2RL3 Gene

neXtProt entry for F2RL3 Gene

Post-translational modifications for F2RL3 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Glycosylation at Asn 56
  • Modification sites at PhosphoSitePlus

Other Protein References for F2RL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for F2RL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for F2RL3

No data available for DME Specific Peptides for F2RL3 Gene

Domains & Families for F2RL3 Gene

Gene Families for F2RL3 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for F2RL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RI0

UniProtKB/Swiss-Prot:

PAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL3: view

Function for F2RL3 Gene

Molecular function for F2RL3 Gene

GENATLAS Biochemistry:
proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein coupled receptor superfamily,activated by thrombin or trypsin
UniProtKB/Swiss-Prot Function:
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Gene Ontology (GO) - Molecular Function for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS --
GO:0015057 thrombin-activated receptor activity IEA --
genes like me logo Genes that share ontologies with F2RL3: view
genes like me logo Genes that share phenotypes with F2RL3: view

Animal Models for F2RL3 Gene

MGI Knock Outs for F2RL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for F2RL3

miRNA for F2RL3 Gene

miRTarBase miRNAs that target F2RL3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for F2RL3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL3 Gene

Localization for F2RL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F2RL3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9618465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with F2RL3: view

Pathways & Interactions for F2RL3 Gene

genes like me logo Genes that share pathways with F2RL3: view

SIGNOR curated interactions for F2RL3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9618465
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 9618465
GO:0007596 blood coagulation IEA,TAS 10500152
GO:0007599 hemostasis IEA --
genes like me logo Genes that share ontologies with F2RL3: view

Drugs & Compounds for F2RL3 Gene

(22) Drugs for F2RL3 Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vorapaxar Approved Pharma PAR-1 antagonist,potent and orally active 15
Argatroban Approved, Investigational Pharma Thrombin mediated fibrinogen cleavage inhibitor 19
AY-NH2 Pharma Selective PAR4 agonist 0
BIBR 953 (Dabigatran, Pradaxa) Pharma Thrombin inhibitor,potent,reversible and direct 0
BIBR-1048 Pharma Thrombin inhibitor 0

(9) Additional Compounds for F2RL3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AYPGKF-NH2
Full agonist, Agonist
GYPGKF-NH2
Full agonist, Agonist
GYPGQV-NH<sub>2</sub>
Full agonist, Agonist

(5) Tocris Compounds for F2RL3 Gene

Compound Action Cas Number
RWJ 56110 Selective PAR1 antagonist 252889-88-6
SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist 1216720-69-2
SLIGKV-NH2 PAR2 receptor agonist 190383-13-2
SLIGRL-NH2 PAR2-activating peptide 171436-38-7
TRAP-6 PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist 141136-83-6

(8) ApexBio Compounds for F2RL3 Gene

Compound Action Cas Number
Argatroban Thrombin mediated fibrinogen cleavage inhibitor 74863-84-6
AY-NH2 Selective PAR4 agonist 352017-71-1
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
BIBR-1048 Thrombin inhibitor 211915-06-9
PAR 4 (1-6) PAR4 agonist 225779-44-2
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2
Thrombin Receptor Agonist Peptide 137339-65-2
Vorapaxar PAR-1 antagonist,potent and orally active 618385-01-6
genes like me logo Genes that share compounds with F2RL3: view

Transcripts for F2RL3 Gene

mRNA/cDNA for F2RL3 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL3 Gene

Coagulation factor II (thrombin) receptor-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for F2RL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL3 Gene

No ASD Table

Relevant External Links for F2RL3 Gene

GeneLoc Exon Structure for
F2RL3
ECgene alternative splicing isoforms for
F2RL3

Expression for F2RL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for F2RL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2RL3 Gene

This gene is overexpressed in Lung (x9.6), Adipose - Subcutaneous (x5.5), Thyroid (x5.3), Breast - Mammary Tissue (x4.9), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for F2RL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.1), Monocytes (10.2), and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for F2RL3 Gene



Protein tissue co-expression partners for F2RL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of F2RL3 Gene:

F2RL3

SOURCE GeneReport for Unigene cluster for F2RL3 Gene:

Hs.137574

mRNA Expression by UniProt/SwissProt for F2RL3 Gene:

Q96RI0-PAR4_HUMAN
Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
genes like me logo Genes that share expression patterns with F2RL3: view

Primer Products

Orthologs for F2RL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F2RL3 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia F2RL3 34 35
  • 82.19 (n)
dog
(Canis familiaris)
Mammalia F2RL3 34 35
  • 79.79 (n)
mouse
(Mus musculus)
Mammalia F2rl3 34 16 35
  • 77.07 (n)
rat
(Rattus norvegicus)
Mammalia F2rl3 34
  • 74.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia F2RL3 35
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves F2RL3 35
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii F2RL3 35
  • 36 (a)
OneToOne
Species where no ortholog for F2RL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL3 Gene

ENSEMBL:
Gene Tree for F2RL3 (if available)
TreeFam:
Gene Tree for F2RL3 (if available)

Paralogs for F2RL3 Gene

Paralogs for F2RL3 Gene

(7) SIMAP similar genes for F2RL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL3: view

Variants for F2RL3 Gene

Sequence variations from dbSNP and Humsavar for F2RL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111390575 -- 16,892,665(+) GAAGC(C/T)TCAGC downstream-variant-500B
rs111401047 -- 16,888,682(+) GCCAC(C/T)GTGCC upstream-variant-2KB
rs111451003 -- 16,889,800(+) CCACC(A/G)TGCTG reference, missense
rs111757562 -- 16,888,381(+) CTGGG(A/G)GGCGC upstream-variant-2KB
rs111890288 -- 16,890,448(+) CGCTG(A/T)GCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for F2RL3 Gene

Variant ID Type Subtype PubMed ID
esv2666431 CNV deletion 23128226

Variation tolerance for F2RL3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F2RL3 Gene

Human Gene Mutation Database (HGMD)
F2RL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
F2RL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL3 Gene

Disorders for F2RL3 Gene

Relevant External Links for F2RL3

Genetic Association Database (GAD)
F2RL3
Human Genome Epidemiology (HuGE) Navigator
F2RL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F2RL3

No disorders were found for F2RL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for F2RL3 Gene

Publications for F2RL3 Gene

  1. Cloning and characterization of human protease-activated receptor 4. (PMID: 9618465) Xu W.-F. … Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 22 64
  2. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn M.L. … Coughlin S.R. (J. Clin. Invest. 1999) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. (PMID: 19058300) Gratio V. … Darmoul D. (Int. J. Cancer 2009) 3 22 64
  5. Regulation of plasmin-induced protease-activated receptor 4 activation in platelets. (PMID: 19437337) Mao Y. … Kunapuli S.P. (Platelets 2009) 3 22 64

Products for F2RL3 Gene

Sources for F2RL3 Gene

Content
Loading form....