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Aliases for F2RL3 Gene

Aliases for F2RL3 Gene

  • F2R Like Thrombin/Trypsin Receptor 3 2 3
  • Coagulation Factor II (Thrombin) Receptor-Like 3 2 3 5
  • Thrombin Receptor-Like 3 3 4
  • PAR-4 3 4
  • PAR4 3 4
  • Coagulation Factor II Receptor-Like 3 4
  • Proteinase-Activated Receptor-4 2
  • Protease-Activated Receptor-4 3

External Ids for F2RL3 Gene

Previous GeneCards Identifiers for F2RL3 Gene

  • GC19P017493
  • GC19P017392
  • GC19P016845
  • GC19P016860
  • GC19P017000
  • GC19P016568
  • GC19P017001
  • GC19P017109
  • GC19P017365
  • GC19P017898

Summaries for F2RL3 Gene

Entrez Gene Summary for F2RL3 Gene

  • Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]

GeneCards Summary for F2RL3 Gene

F2RL3 (F2R Like Thrombin/Trypsin Receptor 3) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and thrombin receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for F2RL3 Gene

  • Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Tocris Summary for F2RL3 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2RL3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL3 Gene

Genomics for F2RL3 Gene

Regulatory Elements for F2RL3 Gene

Promoters for F2RL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around F2RL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for F2RL3 Gene

Chromosome:
19
Start:
16,888,860 bp from pter
End:
16,892,606 bp from pter
Size:
3,747 bases
Orientation:
Plus strand

Genomic View for F2RL3 Gene

Genes around F2RL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2RL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2RL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL3 Gene

Proteins for F2RL3 Gene

  • Protein details for F2RL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RI0-PAR4_HUMAN
    Recommended name:
    Proteinase-activated receptor 4
    Protein Accession:
    Q96RI0
    Secondary Accessions:
    • O76067
    • Q6DK42

    Protein attributes for F2RL3 Gene

    Size:
    385 amino acids
    Molecular mass:
    41133 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2RL3 Gene

neXtProt entry for F2RL3 Gene

Proteomics data for F2RL3 Gene at MOPED

Post-translational modifications for F2RL3 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Glycosylation at Asn 56
  • Modification sites at PhosphoSitePlus

Other Protein References for F2RL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for F2RL3 Gene

Domains & Families for F2RL3 Gene

Gene Families for F2RL3 Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for F2RL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RI0

UniProtKB/Swiss-Prot:

PAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL3: view

Function for F2RL3 Gene

Molecular function for F2RL3 Gene

GENATLAS Biochemistry:
proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein coupled receptor superfamily,activated by thrombin or trypsin
UniProtKB/Swiss-Prot Function:
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Gene Ontology (GO) - Molecular Function for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS --
genes like me logo Genes that share ontologies with F2RL3: view
genes like me logo Genes that share phenotypes with F2RL3: view

Animal Models for F2RL3 Gene

MGI Knock Outs for F2RL3:

Animal Model Products

miRNA for F2RL3 Gene

miRTarBase miRNAs that target F2RL3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL3 Gene

Localization for F2RL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F2RL3 Gene COMPARTMENTS Subcellular localization image for F2RL3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F2RL3: view

Pathways & Interactions for F2RL3 Gene

genes like me logo Genes that share pathways with F2RL3: view

SIGNOR curated interactions for F2RL3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9618465
GO:0007596 blood coagulation IEA,TAS 10500152
GO:0009611 response to wounding TAS 9618465
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 18480058
genes like me logo Genes that share ontologies with F2RL3: view

Drugs & Compounds for F2RL3 Gene

(11) Drugs for F2RL3 Gene - From: DGIdb, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Argatroban Approved, Investigational Pharma Thrombin mediated fibrinogen cleavage inhibitor 18
Vorapaxar Approved Pharma 13
Thrombin Receptor Activator for Peptide 5 (TRAP-5) Pharma 0
RUSALATIDE Pharma 0

(15) Additional Compounds for F2RL3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AYPGKF-NH2
Full agonist, Agonist
GYPGKF-NH2
Full agonist, Agonist
GYPGQV-NH<sub>2</sub>
Full agonist, Agonist
AY-NH2
352017-71-1
SLIGKV-NH2
190383-13-2

(5) Tocris Compounds for F2RL3 Gene

Compound Action Cas Number
AY-NH2 Selective PAR4 agonist 352017-71-1
SLIGKV-NH2 PAR2 receptor agonist 190383-13-2
SLIGRL-NH2 PAR2-activating peptide 171436-38-7
TFLLR-NH2 PAR1-activating peptide 197794-83-5
Thrombin Receptor Agonist Peptide Causes platelet aggregation and secretion 137339-65-2

(2) ApexBio Compounds for F2RL3 Gene

Compound Action Cas Number
Argatroban Thrombin mediated fibrinogen cleavage inhibitor 74863-84-6
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2
genes like me logo Genes that share compounds with F2RL3: view

Transcripts for F2RL3 Gene

mRNA/cDNA for F2RL3 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL3 Gene

Coagulation factor II (thrombin) receptor-like 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL3 Gene

No ASD Table

Relevant External Links for F2RL3 Gene

GeneLoc Exon Structure for
F2RL3
ECgene alternative splicing isoforms for
F2RL3

Expression for F2RL3 Gene

mRNA expression in normal human tissues for F2RL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2RL3 Gene

This gene is overexpressed in Lung (x9.6), Adipose - Subcutaneous (x5.5), Thyroid (x5.3), Breast - Mammary Tissue (x4.9), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for F2RL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.1), Monocytes (10.2), and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for F2RL3 Gene



SOURCE GeneReport for Unigene cluster for F2RL3 Gene Hs.137574

mRNA Expression by UniProt/SwissProt for F2RL3 Gene

Q96RI0-PAR4_HUMAN
Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
genes like me logo Genes that share expression patterns with F2RL3: view

Protein tissue co-expression partners for F2RL3 Gene

Primer Products

In Situ Assay Products

Orthologs for F2RL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia F2RL3 35
  • 82.19 (n)
  • 79.1 (a)
F2RL3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F2RL3 35
  • 79.79 (n)
  • 74.28 (a)
F2RL3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F2rl3 35
  • 77.07 (n)
  • 78.31 (a)
F2rl3 16
F2rl3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia F2RL3 35
  • 99.22 (n)
  • 98.96 (a)
F2RL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F2rl3 35
  • 74.71 (n)
  • 75.6 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia F2RL3 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves F2RL3 36
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii F2RL3 36
  • 36 (a)
OneToOne
Species with no ortholog for F2RL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL3 Gene

ENSEMBL:
Gene Tree for F2RL3 (if available)
TreeFam:
Gene Tree for F2RL3 (if available)

Paralogs for F2RL3 Gene

Paralogs for F2RL3 Gene

(7) SIMAP similar genes for F2RL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL3: view

Variants for F2RL3 Gene

Sequence variations from dbSNP and Humsavar for F2RL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2227346 - 16,890,349(+) CCTTC(A/C/G/T)TCGTG reference, missense
rs2227376 - 16,890,392(+) GGACC(C/T)GAGCC reference, missense
rs773902 - 16,889,821(+) TCGCG(A/G)CTGCT reference, missense
rs2230799 - 16,890,107(+) GCAGC(A/G)GCAGA reference, missense
rs773903 -- 16,889,420(-) GAGAC(A/G)GGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F2RL3 Gene

Variant ID Type Subtype PubMed ID
nsv911168 CNV Loss 21882294
nsv911169 CNV Loss 21882294
nsv911170 CNV Loss 21882294
dgv3755n71 CNV Loss 21882294
nsv911172 CNV Loss 21882294
nsv911174 CNV Loss 21882294
esv2666431 CNV Deletion 23128226

Variation tolerance for F2RL3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F2RL3 Gene

HapMap Linkage Disequilibrium report
F2RL3
Human Gene Mutation Database (HGMD)
F2RL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL3 Gene

Disorders for F2RL3 Gene

Relevant External Links for F2RL3

Genetic Association Database (GAD)
F2RL3
Human Genome Epidemiology (HuGE) Navigator
F2RL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F2RL3

No disorders were found for F2RL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for F2RL3 Gene

Publications for F2RL3 Gene

  1. Cloning and characterization of human protease-activated receptor 4. (PMID: 9618465) Xu W.-F. … Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. (PMID: 19058300) Gratio V. … Darmoul D. (Int. J. Cancer 2009) 3 23
  3. Regulation of plasmin-induced protease-activated receptor 4 activation in platelets. (PMID: 19437337) Mao Y. … Kunapuli S.P. (Platelets 2009) 3 23
  4. Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function. (PMID: 19667088) Megyeri M. … GA!l P. (J. Immunol. 2009) 3 23
  5. The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine. (PMID: 18480058) GrenegAYrd M. … Lindahl T.L. (J. Biol. Chem. 2008) 3 23

Products for F2RL3 Gene

Sources for F2RL3 Gene

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