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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F2RL3 Gene

protein-coding   GIFtS: 62
GCID: GC19P017109

coagulation factor II (thrombin) receptor-like 3
 Explore 19 diseases affiliated with
F2RL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for F2RL3    

Aliases
for F2RL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Coagulation Factor II (Thrombin) Receptor-Like 31 2     Protease-Activated Receptor-42
PAR41 2 3 5     Proteinase-Activated Receptor 42
Thrombin Receptor-Like 32 3     Coagulation Factor II Receptor-Like 33
PAR-42 3     

External Ids:    HGNC: 35401   Entrez Gene: 90022   Ensembl: ENSG000001275337   OMIM: 6027795   UniProtKB: Q96RI03   

Export aliases for F2RL3 gene to outside databases

Previous GC identifers: GC19P017493 GC19P017392 GC19P016845 GC19P016860 GC19P017000 GC19P016568 GC19P017001


Summaries
for F2RL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for F2RL3:
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region
receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated
receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino
terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis.
May play a role in platelets activation

summary for F2RL3:
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors,
activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide
ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling.
Four subtypes of receptors have so far been cloned (PAR1-4). PAR4 tissue distribution is different from
other PAR family members, with highest levels detected in the lung, pancreas, thyroid and testes. This
receptor is localized to human chromosome 19p12. PAR4 is sensitive to both alpha- and gamma-thrombin, yet
has a low affinity for the peptide. PAR4 therefore may function as a low affinity thrombin receptor that is
activated at conditions where high concentrations of thrombin are achieved. This receptor helps to sustain
platelet aggregation during prolonged thrombin exposure, as unlike PAR1, it is slowly inactivated.

Gene Wiki entry for F2RL3


Genomic Views
for F2RL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F2RL3 gene promoter:
         GR   C/EBPbeta   CUTL1   E47   E2F-1   E2F   COMP1   STAT3   GR-alpha   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: F2RL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for F2RL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F2RL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p12

F2RL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2RL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017109:  view genomic region     (about GC identifiers)

Start:
 16,999,826 bp from pter      End:
 17,002,830 bp from pter
Size:
 3,005 bases      Orientation:
 plus strand

Proteins
for F2RL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0 (See protein sequence)
Recommended Name: Proteinase-activated receptor 4 precursor  
Size: 385 amino acids; 41133 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for F2RL3:
2ZPK (3D)        3QDZ (3D)    
Secondary accessions: O76067 Q6DK42

Explore the universe of human proteins at neXtProt for F2RL3: NX_Q96RI0

Post-translational modifications:

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96RI0

    • F2RL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003941.2  
    ENSEMBL proteins: 
     ENSP00000248076  
    Reactome Protein details: Q96RI0
    Human Recombinant Protein Products: 
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    Uscn Proteins for F2RL3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9618465


    F2RL3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for F2RL3

    Protein Domains /
    Families
    for F2RL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    F2RL3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003912 Protea_act_rcpt
     IPR003944 Prot_act_rcpt_4
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96RI0

    ProtoNet protein and cluster: Q96RI0

    2 Blocks protein families:
    IPB003912 Protease activated receptor precursor signature
    IPB003944 Protease activated receptor 2 precursor signature


    UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for F2RL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
    Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis.
    May play a role in platelets activation

         Genatlas biochemistry entry for F2RL3:
    proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein coupled receptor
    superfamily,activated by thrombin or trypsin

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015057thrombin receptor activity IEA--


    F2RL3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for F2RL3:
     Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for F2rl3):
     homeostasis/metabolism  immune system  mortality/aging 

    F2RL3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for F2RL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		GPCRs, Class A Rhodopsin-like0.41
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    		Peptide ligand-binding receptors0.61
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Cell adhesion_Integrin inside-out signaling
    		Cell adhesion_Integrin inside-out signaling1.00
    		Cell adhesion Integrin inside-out signaling0.99
    4Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    5G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for F2RL3
        Cell adhesion Integrin inside-out signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F2RL3
        G12-G13 in Cellular Signaling
    JAK-STAT Pathway
    Thrombin Signaling

    1 GeneGo (Thomson Reuters) Pathway for F2RL3
        Cell adhesion Integrin inside-out signaling

    1 BioSystems Pathway for F2RL3 
        GPCRs, Class A Rhodopsin-like

    5/11        Reactome Pathways for F2RL3 (see all 11)
        GPCR downstream signaling
    Hemostasis
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR

    1 PharmGKB Pathway for F2RL3
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for F2RL3):
        Neuroactive ligand-receptor interaction


    F2RL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F2RL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/133 Interacting proteins for F2RL3 (Q96RI03 ENSP000002480764) via UniProtKB, MINT, STRING, and/or I2D (see all 133)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    F2RL2O002543, ENSP000002966414I2D: score=1 STRING: ENSP00000296641
    EGR2P111613I2D: score=1 
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    ARRB1ENSP000003771414STRING: ENSP00000377141
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9618465
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS9618465
    GO:0007596blood coagulation TAS--
    GO:0009611response to wounding TAS9618465
    GO:0030168platelet activation TAS--


    F2RL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for F2RL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F2RL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for F2RL3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    tcY-NH2Selective PAR4 antagonist[327177-34-4]
    PAR 4 (1-6)PAR4 peptide fragment; acts as a PAR4 agonist[225779-44-2]
    AY-NH2Selective PAR4 agonist[352017-71-1]
    10/14 Novoseek chemical compound relationships for F2RL3 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 53.1 2 19954432 (1), 10908720 (1)
    adp 52 17 12871418 (4), 15078882 (3), 12008957 (2), 10820018 (2) (see all 9)
    hirudin 50.3 1 15118533 (1)
    calcium 43.3 40 16939417 (4), 10664248 (2), 17525299 (2), 19437337 (2) (see all 17)
    fibrinogen 38.7 3 19954432 (1), 17200114 (1), 11986217 (1)
    thromboxane 33.7 11 12006403 (5), 12888878 (3), 17988878 (1)
    sb 203580 30.4 1 15923365 (1)
    cytochalasin d 21.6 4 16702038 (4)
    pge2 12.6 1 11907122 (1)
    epinephrine 8.12 2 16420577 (1), 18480058 (1)

    Search CenterWatch for drugs/clinical trials and news about F2RL3 / PAR4 

    Transcripts
    for F2RL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for F2RL3 gene: 
    NM_003950.2  

    Unigene Cluster for F2RL3:

    Coagulation factor II (thrombin) receptor-like 3
    Hs.137574  [show with all ESTs]
    Unigene Representative Sequence: AF055917
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248076(uc002nfa.3)

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF055917.1 AF080214.1 AY431102.1 BC074782.2 

    1 DOTS entry:

    DT.75100765 

    15 AceView cDNA sequences:

    AW206493 AW207357 BC074782 BQ286510 AY431102 NM_003950 AF080214 AF055917 
    AW138148 BQ269855 AW104737 AI344017 BG142112 AI739295 AW168359 

    GeneLoc Exon Structure


    Expression
    for F2RL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F2RL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGCGGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    F2RL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See F2RL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F2RL3

    SOURCE GeneReport for Unigene cluster: Hs.137574

    UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
    Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not
    expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets

        SABiosciences Expression via Pathway-Focused PCR Array including F2RL3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for F2RL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for F2RL3 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F2RL31 coagulation factor II (thrombin) receptor-like 3 58.88(n)
    51.23(a)    		   420139  XM_418256.3  XP_418256.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7933151 proteinase-activated receptor 4-like 52.59(n)
    46.67(a)    		   793315  XM_001333019.2  XP_001333055.2 


    ENSEMBL Gene Tree for F2RL3 (if available)
    TreeFam Gene Tree for F2RL3 (if available) 

    Paralogs
    for F2RL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F2RL3 gene
    GPR42  FFAR32  GPR682  P2RY82  F2RL12  GPR652  FFAR22  F2RL22  
    GPR1322  FFAR12  GPR422  F2R2  
    7 SIMAP similar genes for F2RL3 using alignment to 2 protein entries:     PAR4_HUMAN (see all proteins):
    F2RL2    F2RL1    P2RY8    F2R    CYSLTR2    KPG_011
    P2RY6

    F2RL3 for paralogs           About GeneDecksing



    Genomic Variants
    for F2RL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/128 NCBI SNPs in F2RL3 are shown (see all 128)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1486660241,2
    		--16998040(+) CACCAC/TGTTGG 1 -- us2k10--------
    rs1860800171,2
    		--16998108(+) TGGGAA/TTACAG 1 -- us2k10--------
    rs1896166451,2
    		--16998171(+) AACCAC/TCCTGC 1 -- us2k10--------
    rs7739071,2
    		C,F,--16998188(-) AGTCCG/AGTGAT 1 -- us2k115Minor allele frequency- A:0.49NA EA WA CSA 734
    rs1412944981,2
    		--16998280(+) TTTCCA/GTGTGC 1 -- us2k10--------
    rs356375621,2
    		C,F,--16998289(+) GCTGAG/AGGTGT 1 -- us2k15Minor allele frequency- A:0.06NA WA 244
    rs796939471,2
    		C,F,--16998384(+) GGGCCT/CCTGAG 1 -- us2k13Minor allele frequency- C:0.07WA NA EA 358
    rs118797831,2
    		C,F,H,--16998406(+) GCTAGA/CCTCTC 1 -- us2k17Minor allele frequency- C:0.18NA WA CSA 129
    rs1819511121,2
    		--16998492(+) GATCCA/CCGAGT 1 -- us2k10--------
    rs1507698031,2
    		--16998495(+) CCCCGA/GGTGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for F2RL3 (16999826 - 17002830 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for F2RL3: --

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    Disorders / Diseases
    for F2RL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    F2RL3 for disorders           About GeneDecksing

    OMIM gene information: 602779    OMIM disorders: --

    19 diseases for F2RL3:    About MalaCards
    hermansky-pudlak syndrome    thyroiditis    thrombosis    hepatocellular carcinoma
    glomerulosclerosis    astrocytoma    chondrosarcoma    gingivitis
    colon cancer    gastric cancer    pancreatic cancer    lung cancer
    prostate cancer    breast cancer    pancreatitis    carcinoma
    neuroblastoma    prostatitis    sepsis

    9 Novoseek disease relationships for F2RL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 42.9 4 16952995 (1), 17151288 (1), 12384423 (1)
    inflammation 34.5 5 15451771 (1), 10702240 (1), 14637278 (1), 11440983 (1)
    restenosis 29.9 1 16952995 (1)
    astrocytoma 6.74 3 10664248 (2)
    bleeding 0 2 12008957 (1), 14607253 (1)
    necrosis 0 1 11440983 (1)
    hepatocellular carcinoma 0 2 17323377 (1), 19360302 (1)
    tumors 0 2 17433115 (1), 11440983 (1)
    edema 0 1 15451771 (1)

    Human Genome Epidemiology (HuGE) Navigator: F2RL3 (5 documents)

    Export disorders for F2RL3 gene to outside databases

    Publications
    for F2RL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F2RL3 gene, integrated from 9 sources (see all 170):
    (articles sorted by number of sources associating them with F2RL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human protease-activated receptor 4. (PubMed id 9618465)1, 2, 3, 9 Xu W.-F.... Foster D.C. (1998)
    2. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 2, 9 Kahn M.L....Coughlin S.R. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)1, 2 Kahn M.L....Coughlin S.R. (1998)
    5. A dual thrombin receptor system for platelet activation. (PubMed id 9716134)1, 2 Kahn M.L.... Coughlin S.R. (1998)
    6. The role of PAR4 in thrombin-induced thromboxane production in human platelets. (PubMed id 12888878)1, 9 Wu C.C....Teng C.M. (2003)
    7. Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1. (PubMed id 19053259)1, 9 Nieman M.T. (2008)
    8. Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. (PubMed id 12871418)1, 9 Adam F....Jandrot-Perrus M. (2003)
    9. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. (PubMed id 11907122)1, 9 Asokananthan N....Stewart G.A. (2002)
    10. Regulation of plasmin-induced protease-activated receptor 4 activation in platelets. (PubMed id 19437337)1, 9 Mao Y....Kunapuli S.P. (2009)

    External Searches for F2RL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing F2RL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9002 HGNC: 3540 AceView: F2RL3 Ensembl:ENSG00000127533 euGenes: HUgn9002
    ECgene: F2RL3 Kegg: 9002 H-InvDB: F2RL3

    Other Databases showing F2RL3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing F2RL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F2RL3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/f2rl3/

    Intellectual Property
    for F2RL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for F2RL3 gene:
    Search GeneIP for patents involving F2RL3

    GeneCards and IP:
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