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Aliases for F2RL3 Gene

Aliases for F2RL3 Gene

  • Coagulation Factor II (Thrombin) Receptor-Like 3 2 3
  • PAR4 3 4 6
  • Thrombin Receptor-Like 3 3 4
  • PAR-4 3 4
  • Coagulation Factor II Receptor-Like 3 4
  • Proteinase-Activated Receptor-4 2
  • Proteinase-Activated Receptor 4 3
  • Protease-Activated Receptor-4 3

External Ids for F2RL3 Gene

Summaries for F2RL3 Gene

Entrez Gene Summary for F2RL3 Gene

  • Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]

GeneCards Summary for F2RL3 Gene

F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3) is a Protein Coding gene. Diseases associated with F2RL3 include hepatocellular carcinoma. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include thrombin receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for F2RL3 Gene

  • Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Tocris Summary for F2RL3 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling. Four subtypes of receptors have so far been cloned (PAR1-4). PAR4 tissue distribution is different from other PAR family members, with highest levels detected in the lung, pancreas, thyroid and testes. This receptor is localized to human chromosome 19p12. PAR4 is sensitive to both alpha- and gamma-thrombin, yet has a low affinity for the peptide. PAR4 therefore may function as a low affinity thrombin receptor that is activated at conditions where high concentrations of thrombin are achieved. This receptor helps to sustain platelet aggregation during prolonged thrombin exposure, as unlike PAR1, it is slowly inactivated.

Gene Wiki entry for F2RL3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL3 Gene

Genomics for F2RL3 Gene

Genomic Location for F2RL3 Gene

16,888,860 bp from pter
16,892,606 bp from pter
3,747 bases
Plus strand

Genomic View for F2RL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F2RL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL3 Gene

Regulatory Elements for F2RL3 Gene

Proteins for F2RL3 Gene

  • Protein details for F2RL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteinase-activated receptor 4
    Protein Accession:
    Secondary Accessions:
    • O76067
    • Q6DK42

    Protein attributes for F2RL3 Gene

    385 amino acids
    Molecular mass:
    41133 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2RL3 Gene

neXtProt entry for F2RL3 Gene

Proteomics data for F2RL3 Gene at MOPED

Post-translational modifications for F2RL3 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn56

Other Protein References for F2RL3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for F2RL3 Gene

Domains for F2RL3 Gene

Gene Families for F2RL3 Gene

  • F2R :GPCR / Class A : Protease activated receptors

Suggested Antigen Peptide Sequences for F2RL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96RI0
genes like me logo Genes that share domains with F2RL3: view

Function for F2RL3 Gene

Molecular function for F2RL3 Gene

GENATLAS Biochemistry: proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein coupled receptor superfamily,activated by thrombin or trypsin
UniProtKB/Swiss-Prot Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Gene Ontology (GO) - Molecular Function for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0015057 thrombin receptor activity IEA --
genes like me logo Genes that share ontologies with F2RL3: view

Phenotypes for F2RL3 Gene

genes like me logo Genes that share phenotypes with F2RL3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for F2RL3 Gene

Localization for F2RL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for F2RL3 Gene COMPARTMENTS Subcellular localization image for F2RL3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9618465
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with F2RL3: view

Pathways for F2RL3 Gene

genes like me logo Genes that share pathways with F2RL3: view

Pathways by source for F2RL3 Gene

Gene Ontology (GO) - Biological Process for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10702240
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 9618465
GO:0007596 blood coagulation TAS --
GO:0009611 response to wounding TAS 9618465
genes like me logo Genes that share ontologies with F2RL3: view

Compounds for F2RL3 Gene

(5) Tocris Compounds for F2RL3 Gene

Compound Action Cas Number
2-Furoyl-LIGRLO-amide Potent and selective PAR2 agonist [729589-58-6]
SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist [245520-69-8]
SLIGKV-NH2 PAR2 receptor agonist [190383-13-2]
TFLLR-NH2 PAR1-activating peptide [197794-83-5]
TRAP-6 PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist [141136-83-6]

(3) IUPHAR Ligand for F2RL3 Gene

Ligand Type Action Affinity Pubmed IDs
GYPGKF-NH2 Agonist Full agonist
GYPGQV-NH2 Agonist Full agonist
AYPGKF-NH2 Agonist Full agonist

(14) Novoseek inferred chemical compound relationships for F2RL3 Gene

Compound -log(P) Hits PubMed IDs
serine 53.1 2
adp 52 16
hirudin 50.3 1
calcium 43.3 26
fibrinogen 38.7 3
genes like me logo Genes that share compounds with F2RL3: view

Transcripts for F2RL3 Gene

mRNA/cDNA for F2RL3 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL3 Gene

Coagulation factor II (thrombin) receptor-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL3 Gene

No ASD Table

Relevant External Links for F2RL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F2RL3 Gene

mRNA expression in normal human tissues for F2RL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2RL3 Gene

This gene is overexpressed in Lung (9.6), Adipose - Subcutaneous (5.5), Thyroid (5.3), Breast - Mammary Tissue (4.9), and Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for F2RL3 Gene

SOURCE GeneReport for Unigene cluster for F2RL3 Gene Hs.137574

mRNA Expression by UniProt/SwissProt for F2RL3 Gene

Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets
genes like me logo Genes that share expressions with F2RL3: view

Orthologs for F2RL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F2RL3 35
  • 99.22 (n)
  • 98.96 (a)
F2RL3 36
  • 99 (a)
(Bos Taurus)
Mammalia F2RL3 35
  • 82.19 (n)
  • 79.1 (a)
F2RL3 36
  • 79 (a)
(Canis familiaris)
Mammalia F2RL3 35
  • 79.79 (n)
  • 74.28 (a)
F2RL3 36
  • 71 (a)
(Mus musculus)
Mammalia F2rl3 35
  • 77.07 (n)
  • 78.31 (a)
F2rl3 16
F2rl3 36
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
-- 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia F2RL3 36
  • 55 (a)
(Rattus norvegicus)
Mammalia F2rl3 35
  • 74.71 (n)
  • 75.6 (a)
(Gallus gallus)
Aves F2RL3 36
  • 45 (a)
(Danio rerio)
Actinopterygii F2RL3 36
  • 36 (a)
Species with no ortholog for F2RL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL3 Gene

Gene Tree for F2RL3 (if available)
Gene Tree for F2RL3 (if available)

Paralogs for F2RL3 Gene

Paralogs for F2RL3 Gene

Selected SIMAP similar genes for F2RL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL3: view

Variants for F2RL3 Gene

Sequence variations from dbSNP and Humsavar for F2RL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs773902 - 16,889,821(+) TCGCG(A/G)CTGCT missense, reference
rs773903 -- 16,889,420(-) GAGAC(A/G)GGATA intron-variant
rs773904 -- 16,889,320(-) CTGCA(C/T)CCCAA intron-variant
rs773905 -- 16,889,086(-) CCGGT(A/G)GAGAT utr-variant-5-prime, upstream-variant-2KB
rs773906 -- 16,887,911(-) CAACC(C/T)GTCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for F2RL3 Gene

Variant ID Type Subtype PubMed ID
nsv911168 CNV Loss 21882294
nsv911169 CNV Loss 21882294
nsv911170 CNV Loss 21882294
dgv3755n71 CNV Loss 21882294
nsv911172 CNV Loss 21882294
nsv911174 CNV Loss 21882294
esv2666431 CNV Deletion 23128226

Relevant External Links for F2RL3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL3 Gene

Disorders for F2RL3 Gene

(1) MalaCards Diseases for F2RL3 Gene

Search for F2RL3 Gene in MalaCards »

(9) Novoseek inferred disease relationships for F2RL3 Gene

Disease -log(P) Hits PubMed IDs
thrombosis 42.9 3
inflammation 34.5 4
restenosis 29.9 1
astrocytoma 6.74 2
bleeding 0 2

Relevant External Links for F2RL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with F2RL3: view

No data available for UniProtKB/Swiss-Prot for F2RL3 Gene

Publications for F2RL3 Gene

  1. Cloning and characterization of human protease-activated receptor 4. (PMID: 9618465) Xu W.-F. … Foster D.C. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn M.L. … Coughlin S.R. (J. Clin. Invest. 1999) 3 4 23
  3. Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. (PMID: 11714832) Miike S. … Kita H. (J. Immunol. 2001) 3 23
  4. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. (PMID: 11907122) Asokananthan N. … Stewart G.A. (J. Immunol. 2002) 3 23
  5. PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets. (PMID: 12006403) Henriksen R.A. … Hanks V.K. (Arterioscler. Thromb. Vasc. Biol. 2002) 3 23

Products for F2RL3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate F2RL3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for F2RL3
    • Block miRNA regulation of F2RL3 using miScript Target Protectors
    • Addgene plasmids for F2RL3

    Sources for F2RL3 Gene

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