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F2RL3 Gene

protein-coding GIFtS: 62

GC19P016860

coagulation factor II (thrombin) receptor-like 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
PAR-4 ^³
PAR4 ^¹, ², ³, ⁵

Descriptions
Coagulation factor II receptor-like 3 ^³
Thrombin receptor-like 3 ^³
coagulation factor II (thrombin) receptor-like 3 ^²
protease-activated receptor-4 ^²
proteinase-activated receptor-4 ^²

External Ids
HGNC: 3540¹
Entrez Gene: 9002²
UniProtKB: Q96RI0³
Ensembl: ENSG00000127533⁷

Search outside databases for aliases for F2RL3 gene

Previous GC identifers: GC19P017493 GC19P017392 GC19P016845

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for F2RL3:

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of

7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is

also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic

cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered

ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by

RefSeq]

UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0

Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate

phosphoinositide hydrolysis. May play a role in platelets activation

Gene Wiki entry for F2RL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F2RL3 gene

Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p12

F2RL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P016860: (about GC identifiers)

Start:	16,860,826 bp from pter
End:	16,863,830 bp from pter
Size:	3,005 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0 (See protein sequence)

Recommended Name: Proteinase-activated receptor 4 precursor

Size: 385 amino acids; 41133 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2ZPK (3D)

Secondary accessions: O76067 Q6DK42

Post-translational modifications:

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand¹

REFSEQ proteins: NP_003941.2

ENSEMBL proteins:

ENSP00000248076

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant F2RL3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Proteinase Activated Receptor 4)
	Human Recombinant Proteins from Abnova (F2RL3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9618465
GO:0005887	integral to plasma membrane	TAS	9618465

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Antibodies for F2RL3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for F2RL3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Proteinase Activated Receptor 4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F2RL3)
	Novus Biologicals Antibodies for F2RL3

Assays for F2RL3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96RI0

ProtoNet protein and cluster: Q96RI0

2 Blocks protein families:

IPB003912 Protease activated receptor precursor signature

IPB003944 Protease activated receptor 2 precursor signature

UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F2RL3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F2RL3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003950

Applied Biosystems Silencer® siRNAs for F2RL3

Sigma-Aldrich siRNA and siRNA Panels for F2RL3

Sigma-Aldrich shRNA Panels and shRNA for F2RL3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of F2RL3

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003950
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003950
untagged cDNA clone in CMV expression vector: NM_003950

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003950

UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0

Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate

phosphoinositide hydrolysis. May play a role in platelets activation

Genatlas biochemistry entry for F2RL3:

proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein

coupled receptor superfamily,activated by thrombin or trypsin

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for F2rl3):

homeostasis/metabolism

immune system

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0015057	thrombin receptor activity	TAS	10500152

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for F2RL3 (Your Favorite Gene powered by Ingenuity)

Thrombin Signaling

GeneDecks F2RL3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for F2RL3

5/29 Interacting proteins for F2RL3 (ENSP00000248076³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F2R	ENSP00000321326³	STRING (score=.912)
GNAQ	ENSP00000286548³	STRING (score=.908)
F2RL1	ENSP00000296677³	STRING (score=.907)
ENSG00000176533	ENSP00000371594³	STRING (score=.899)
ENSG00000182625	ENSP00000332379³	STRING (score=.899)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9618465 10702240
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	9618465
GO:0007596	blood coagulation	TAS	10500152
GO:0009611	response to wounding	TAS	9618465

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for F2RL3

Browse Small Molecules at Sigma-Aldrich

Compounds for F2RL3 available from Tocris Bioscience

Compound	Action	CAS number
tcY-NH2	Selective PAR4 antagonist	[327177-34-4]
PAR 4 (1-6)	PAR4 peptide fragment; acts as a PAR4 agonist	[225779-44-2]
AY-NH2	Selective PAR4 agonist	[352017-71-1]

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6 Novoseek chemical compound relationships for F2RL3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adp	53.72	17	12871418 (4), 15078882 (3), 12008957 (2), 10820018 (2) (see all 9)
calcium	42.70	40	16939417 (4), 10664248 (2), 17525299 (2), 19437337 (2) (see all 17)
fibrinogen	37.70	2	17200114 (1), 11986217 (1)
thromboxane	35.37	11	12006403 (5), 12888878 (3), 17988878 (1)
arachidonic acid	2.64	1	17988878 (1)
tyrosine	0.00	2	17433115 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F2RL3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F2RL3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003950

Sigma-Aldrich siRNA and siRNA Panels for F2RL3

Sigma-Aldrich shRNA Panels and shRNA for F2RL3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003950

REFSEQ mRNAs for F2RL3 gene:

NM_003950.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003950

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003950
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003950
                                 untagged cDNA clone in CMV expression vector: NM_003950

Additional cDNA sequence:

AF055917.1 AF080214.1 AY431102.1 BC074782.2

1 DOTS entry:

DT.75100765

15 AceView cDNA sequences:

BC074782 BQ286510 AW207357 AW206493 AY431102 AF055917 AI344017 AW138148

AW104737 NM_003950 BG142112 BQ269855 AI739295 AF080214 AW168359

highest scoring ESTs for F2RL3:

AF055917 AF080214 AI344017 AI739295 AW138148 AW168359 AW206493 AW207357 AY431102 BC074782

Unigene Cluster for F2RL3:

Coagulation factor II (thrombin) receptor-like 3

Hs.137574 [show with all ESTs]

Unigene Representative Sequence: AF055917

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000248076

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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F2RL3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F2RL3

¹ / ² / ³

3 probe-sets matching F2RL3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35571_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF055917	0.80	1.00	0.91	1
207221_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003950	0.40	1.00	0.76	1
207221_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F2RL3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGCGGCAGA

SOURCE GeneReport for Unigene cluster: Hs.137574
Expression variation in blood from EXPOLDB for F2RL3
UniProtKB/Swiss-Prot: PAR4_HUMAN, Q96RI0
Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and
small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also
detected in platelets

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F2RL3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F2RL3¹	--	coagulation factor II (thrombin) receptor-like 3	79.79(n) 74.28(a)	484846 XM_541962.2 XP_541962.2
chimpanzee (Pan troglodytes)	F2RL3¹	--	coagulation factor II (thrombin) receptor-like 3	99.22(n) 98.96(a)	455829 XM_512484.2 XP_512484.2
cow (Bos taurus)	F2RL3¹	--	coagulation factor II (thrombin) receptor-like 3	82.19(n) 79.1(a)	538963 NM_001076138.1 NP_001069606.1
mouse (Mus musculus)	F2rl3^{1, 5}	8 (33.00 cM)⁵	coagulation factor II (thrombin) receptor-like 3^{1, 5}	77.25(n)¹ 78.31(a)¹	14065¹ NM_007975.3¹ NP_032001.2¹ AF080215⁵ AI413964⁵ (see all 9)
chicken (Gallus gallus)	F2RL3¹	--	coagulation factor II (thrombin) receptor-like 3	60.1(n) 52.55(a)	420139 XM_418256.2 XP_418256.2

About this table Species with no ortholog for F2RL3

ENSEMBL Gene Tree for F2RL3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F2RL3 gene

P2RY8² GPR18² F2RL1² F2R² F2RL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/45 NCBI SNPs in F2RL3 are shown (see all 45 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs773902^1,2	A,C,F,H	16861632(+)	`TCGCGG/ACTGCT`	1	T/A	mis¹ ese³		15	EA NA MN EU WA	1202
--	rs773905^1,2	A,C,F	16860897(-)	`CCGGTA/GGAGAT`	1	--	ut5¹ ese³		12	EA NA NS	2310
	rs2227343^1,2	C,F,H	16860951(+)	`GGTCCG/AGCGAG`	1	--	ut5¹ ese³		4	NS EA	246
	rs2227346^1,2	C,F,H	16862160(+)	`CCTTCG/TTCGTG`	1	F/V	mis¹		6	NS EU EA NA	456
	rs2227341^1,2	C,F,H	16860700(+)	`ACCGGG/AGGTGC`	1	--	ng5¹		6	NS EU EA WA	512
	rs2227376^1,2	C,F	16862203(+)	`GGACCC/TGAGCC`	1	P/L	mis¹ ese³		7	NS NA EU EA WA	584
	rs773906^1,2	A,H	16859722(-)	`CAACCC/TGTCGT`	1	--	ng5¹		4	EU EA WA	418
	rs2227339^1,2	F,H	16860136(+)	`CCTGAC/TGCTGG`	1	--	ng5¹		6	NS EU EA WA	510
	rs2227349^1,2	F,H	16862551(+)	`CTAGCG/AGAGGT`	1	--	ut3¹ ese³		4	NS EA	254
--	rs2227353^1,2	C,F	16863121(+)	`cccagC/Tcactc`	1	--	ut3¹ ese³		2	NS	94

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HapMap Linkage Disequilibrium images for F2RL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602779

9 Novoseek disease relationships for F2RL3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombosis	43.39	4	16952995 (1), 17151288 (1), 12384423 (1)
inflammation	36.25	5	15451771 (1), 10702240 (1), 14637278 (1), 11440983 (1)
restenosis	32.32	1	16952995 (1)
astrocytoma	9.03	3	10664248 (2)
necrosis	0.00	1	11440983 (1)
tumors	0.00	2	17433115 (1), 11440983 (1)
hepatocellular carcinoma	0.00	2	17323377 (1), 19360302 (1)
bleeding	0.00	2	12008957 (1), 14607253 (1)
edema	0.00	1	15451771 (1)

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Human Genome Epidemiology Navigator: F2RL3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/144 PubMed articles for F2RL3 gene (see all 144 ):

Cloning and characterization of human protease-activated receptor 4. (PubMed id 9618465)^{1, 2, 3, 4} Xu W.-F.... Foster D.C. (1998)
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)^{1, 3, 4} Kahn M.L....Coughlin S.R. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)^{3, 4} Kahn M.L....Coughlin S.R. (1998)
A dual thrombin receptor system for platelet activation. (PubMed id 9716134)^{3, 4} Kahn M.L.... Coughlin S.R. (1998)
The role of PAR4 in thrombin-induced thromboxane production in human platelets. (PubMed id 12888878)^{1, 3} Wu C.C....Teng C.M. (2003)
Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1. (PubMed id 19053259)^{1, 3} Nieman M.T. (2008)
Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. (PubMed id 12871418)^{1, 3} Adam F....Jandrot-Perrus M. (2003)
Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. (PubMed id 11907122)^{1, 3} Asokananthan N....Stewart G.A. (2002)
PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets. (PubMed id 12006403)^{1, 3} Henriksen R.A. and Hanks V.K. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9002	HGNC: 3540	AceView: F2RL3	Ensembl:ENSG00000127533	euGenes: HUgn9002
ECgene: F2RL3	H-InvDB: F2RL3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/f2rl3/

Licensable Technologies for F2RL3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for F2RL3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F2RL3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F2RL3		Antibodies for F2RL3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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	"Your Favorite Gene" Pathways		feedback

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F2RL3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for F2RL3

Summaries
for F2RL3

Genomic Location
for F2RL3

Proteins
for F2RL3

Protein Domains/
Families
for F2RL3

Gene Function
for F2RL3

Pathways & Interactions
for F2RL3

Drugs & Compounds
for F2RL3

Transcripts
for F2RL3

Expression
for F2RL3

Orthologs
for F2RL3

Paralogs
for F2RL3

SNPs/Variants
for F2RL3

Disorders & Mutations
for F2RL3

Medical News
for F2RL3

Publications
for F2RL3

Search for F2RL3

Genome Databases showing F2RL3

Other Databases showing F2RL3

Specialized Databases showing F2RL3

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F2RL3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor F2RL3

Summariesfor F2RL3

Genomic Locationfor F2RL3

Proteinsfor F2RL3

Protein Domains/Familiesfor F2RL3

Gene Functionfor F2RL3

Pathways & Interactionsfor F2RL3

Drugs & Compoundsfor F2RL3

Transcriptsfor F2RL3

Expression for F2RL3

Orthologsfor F2RL3

Paralogsfor F2RL3

SNPs/Variantsfor F2RL3

Disorders & Mutationsfor F2RL3

Medical Newsfor F2RL3

Publicationsfor F2RL3

Search for F2RL3

Genome Databases showing F2RL3

Other Databases showing F2RL3

Specialized Databases showing F2RL3

Licensable Technologiesfor F2RL3

Servicesfor F2RL3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F2RL3

Summaries
for F2RL3

Genomic Location
for F2RL3

Proteins
for F2RL3

Protein Domains/
Families
for F2RL3

Gene Function
for F2RL3

Pathways & Interactions
for F2RL3

Drugs & Compounds
for F2RL3

Transcripts
for F2RL3

Expression
for F2RL3

Orthologs
for F2RL3

Paralogs
for F2RL3

SNPs/Variants
for F2RL3

Disorders & Mutations
for F2RL3

Medical News
for F2RL3

Publications
for F2RL3

Licensable Technologies
for F2RL3

Services
for F2RL3