Aliases for F2RL3 Gene
External Ids for F2RL3 Gene
Previous GeneCards Identifiers for F2RL3 Gene
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
GeneCards Summary for F2RL3 Gene
F2RL3 (F2R Like Thrombin/Trypsin Receptor 3) is a Protein Coding gene. Among its related pathways are Complement and coagulation cascades and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and thrombin receptor activity. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for F2RL3 Gene
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.