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Aliases for F2RL3 Gene

Aliases for F2RL3 Gene

  • F2R Like Thrombin Or Trypsin Receptor 3 2 3 5
  • Coagulation Factor II (Thrombin) Receptor-Like 3 2 3
  • F2R Like Thrombin/Trypsin Receptor 3 2 3
  • Thrombin Receptor-Like 3 3 4
  • PAR-4 3 4
  • PAR4 3 4
  • Coagulation Factor II Receptor-Like 3 4
  • Proteinase-Activated Receptor-4 2
  • Proteinase-Activated Receptor 4 3
  • Protease-Activated Receptor-4 3

External Ids for F2RL3 Gene

Previous GeneCards Identifiers for F2RL3 Gene

  • GC19P017493
  • GC19P017392
  • GC19P016845
  • GC19P016860
  • GC19P017000
  • GC19P016568
  • GC19P017001
  • GC19P017109
  • GC19P017365
  • GC19P017898

Summaries for F2RL3 Gene

Entrez Gene Summary for F2RL3 Gene

  • This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]

GeneCards Summary for F2RL3 Gene

F2RL3 (F2R Like Thrombin Or Trypsin Receptor 3) is a Protein Coding gene. Among its related pathways are Complement and coagulation cascades and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.

UniProtKB/Swiss-Prot for F2RL3 Gene

  • Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Tocris Summary for F2RL3 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2RL3 Gene

Additional gene information for F2RL3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL3 Gene

Genomics for F2RL3 Gene

GeneHancer (GH) Regulatory Elements for F2RL3 Gene

Promoters and enhancers for F2RL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I016885 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.6 -595 5.4 HDGF PKNOX1 ARNT YY1 POLR2B ZNF766 E2F8 REST ZNF592 SMARCA4 F2RL3 SIN3B CHERP ENSG00000267904 ENSG00000268743 C19orf44 ENSG00000269578 GTPBP3 ENSG00000268087 SMIM7
GH19I017264 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +377.7 377668 5.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF766 BABAM1 ENSG00000269307 USHBP1 CHERP ABHD8 PLVAP F2RL3 OCEL1 GTPBP3 ENSG00000269427
GH19I017762 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 +873.9 873850 1.1 HDGF HDAC1 YBX3 PKNOX1 BMI1 RFX5 ZNF366 RCOR1 FOS KLF13 MAP1S B3GNT3 INSL3 PLVAP NXNL1 F2RL3 GC19M017755 GC19P020271 FCHO1
GH19I016863 Promoter/Enhancer 0.9 EPDnew Ensembl 12.2 -25.5 -25459 0.4 RUNX3 ZBTB40 SIN3B F2RL3 GC19M016869 GC19M016856 ENSG00000268743
GH19I017487 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.1 +600.6 600649 3.6 ARID4B SIN3A DMAP1 RAD21 ZNF48 ZNF335 SCRT2 ZNF143 RCOR1 KLF7 LOC100507551 SLC27A1 F2RL3 PIR43275
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around F2RL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F2RL3 gene promoter:

Genomic Locations for F2RL3 Gene

Genomic Locations for F2RL3 Gene
chr19:16,888,860-16,892,606
(GRCh38/hg38)
Size:
3,747 bases
Orientation:
Plus strand
chr19:16,999,671-17,003,417
(GRCh37/hg19)

Genomic View for F2RL3 Gene

Genes around F2RL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2RL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2RL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL3 Gene

Proteins for F2RL3 Gene

  • Protein details for F2RL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RI0-PAR4_HUMAN
    Recommended name:
    Proteinase-activated receptor 4
    Protein Accession:
    Q96RI0
    Secondary Accessions:
    • O76067
    • Q6DK42

    Protein attributes for F2RL3 Gene

    Size:
    385 amino acids
    Molecular mass:
    41133 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2RL3 Gene

neXtProt entry for F2RL3 Gene

Post-translational modifications for F2RL3 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Glycosylation at posLast=5656

Other Protein References for F2RL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for F2RL3 Gene

Domains & Families for F2RL3 Gene

Gene Families for F2RL3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for F2RL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RI0

UniProtKB/Swiss-Prot:

PAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL3: view

Function for F2RL3 Gene

Molecular function for F2RL3 Gene

GENATLAS Biochemistry:
proteinase-activated receptor 4,expressed in pancreas,testis,lung,thyroid,small intestine,G protein coupled receptor superfamily,activated by thrombin or trypsin
UniProtKB/Swiss-Prot Function:
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Gene Ontology (GO) - Molecular Function for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS --
GO:0015057 thrombin-activated receptor activity IEA --
genes like me logo Genes that share ontologies with F2RL3: view
genes like me logo Genes that share phenotypes with F2RL3: view

Animal Models for F2RL3 Gene

MGI Knock Outs for F2RL3:

Animal Model Products

miRNA for F2RL3 Gene

miRTarBase miRNAs that target F2RL3

Clone Products

  • Addgene plasmids for F2RL3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL3 Gene

Localization for F2RL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F2RL3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9618465
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with F2RL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for F2RL3 Gene

Pathways & Interactions for F2RL3 Gene

genes like me logo Genes that share pathways with F2RL3: view

SIGNOR curated interactions for F2RL3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for F2RL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9618465
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 9618465
GO:0007596 blood coagulation TAS,IEA 10500152
GO:0007599 hemostasis IEA --
genes like me logo Genes that share ontologies with F2RL3: view

Drugs & Compounds for F2RL3 Gene

(23) Drugs for F2RL3 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vorapaxar Approved Pharma PAR-1 antagonist,potent and orally active 16
Thrombin Approved, Investigational Pharma Target 332
Argatroban Approved, Investigational Pharma Thrombin mediated fibrinogen cleavage inhibitor 19
AY-NH2 Pharma Selective PAR4 agonist 0
BIBR 953 (Dabigatran, Pradaxa) Pharma Thrombin inhibitor,potent,reversible and direct 0

(9) Additional Compounds for F2RL3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AYPGKF-NH2
Full agonist, Agonist
GYPGKF-NH2
Full agonist, Agonist
GYPGQV-NH<sub>2</sub>
Full agonist, Agonist

(5) Tocris Compounds for F2RL3 Gene

Compound Action Cas Number
AY-NH2 Selective PAR4 agonist 352017-71-1
SLIGKV-NH2 PAR2 receptor agonist 190383-13-2
SLIGRL-NH2 PAR2-activating peptide 171436-38-7
TFLLR-NH2 PAR1-activating peptide 197794-83-5
Thrombin Receptor Agonist Peptide Causes platelet aggregation and secretion 137339-65-2

(8) ApexBio Compounds for F2RL3 Gene

Compound Action Cas Number
Argatroban Thrombin mediated fibrinogen cleavage inhibitor 74863-84-6
AY-NH2 Selective PAR4 agonist 352017-71-1
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
BIBR-1048 Thrombin inhibitor 211915-06-9
PAR 4 (1-6) PAR4 agonist 225779-44-2
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2
Thrombin Receptor Agonist Peptide 137339-65-2
Vorapaxar PAR-1 antagonist,potent and orally active 618385-01-6
genes like me logo Genes that share compounds with F2RL3: view

Drug Products

Transcripts for F2RL3 Gene

mRNA/cDNA for F2RL3 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL3 Gene

Coagulation factor II (thrombin) receptor-like 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for F2RL3

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL3 Gene

No ASD Table

Relevant External Links for F2RL3 Gene

GeneLoc Exon Structure for
F2RL3
ECgene alternative splicing isoforms for
F2RL3

Expression for F2RL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F2RL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2RL3 Gene

This gene is overexpressed in Lung (x9.6), Adipose - Subcutaneous (x5.5), Thyroid (x5.3), Breast - Mammary Tissue (x4.9), and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for F2RL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.1), Monocytes (10.2), and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for F2RL3 Gene



Protein tissue co-expression partners for F2RL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of F2RL3 Gene:

F2RL3

SOURCE GeneReport for Unigene cluster for F2RL3 Gene:

Hs.137574

mRNA Expression by UniProt/SwissProt for F2RL3 Gene:

Q96RI0-PAR4_HUMAN
Tissue specificity: Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.

Evidence on tissue expression from TISSUES for F2RL3 Gene

  • Lung(4.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with F2RL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for F2RL3 Gene

Orthologs for F2RL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F2RL3 33 34
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia F2RL3 33 34
  • 82.19 (n)
dog
(Canis familiaris)
Mammalia F2RL3 33 34
  • 79.79 (n)
mouse
(Mus musculus)
Mammalia F2rl3 33 16 34
  • 77.07 (n)
rat
(Rattus norvegicus)
Mammalia F2rl3 33
  • 74.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia F2RL3 34
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves F2RL3 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii F2RL3 34
  • 36 (a)
OneToOne
Species where no ortholog for F2RL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL3 Gene

ENSEMBL:
Gene Tree for F2RL3 (if available)
TreeFam:
Gene Tree for F2RL3 (if available)

Paralogs for F2RL3 Gene

(7) SIMAP similar genes for F2RL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL3: view

Variants for F2RL3 Gene

Sequence variations from dbSNP and Humsavar for F2RL3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000302889 -- 16,887,762(+) A/G upstream_transcript_variant
rs1000477078 -- 16,888,671(+) C/T upstream_transcript_variant
rs1000778813 -- 16,887,872(+) G/A upstream_transcript_variant
rs1000985112 -- 16,891,457(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001168161 -- 16,890,762(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for F2RL3 Gene

Variant ID Type Subtype PubMed ID
esv2666431 CNV deletion 23128226

Variation tolerance for F2RL3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F2RL3 Gene

Human Gene Mutation Database (HGMD)
F2RL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
F2RL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL3 Gene

Disorders for F2RL3 Gene

Additional Disease Information for F2RL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for F2RL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for F2RL3 Gene

Publications for F2RL3 Gene

  1. Cloning and characterization of human protease-activated receptor 4. (PMID: 9618465) Xu WF … Foster DC (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  2. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn ML … Coughlin SR (The Journal of clinical investigation 1999) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. (PMID: 19058300) Gratio V … Darmoul D (International journal of cancer 2009) 3 22 58
  5. Regulation of plasmin-induced protease-activated receptor 4 activation in platelets. (PMID: 19437337) Mao Y … Kunapuli SP (Platelets 2009) 3 22 58

Products for F2RL3 Gene

  • Addgene plasmids for F2RL3

Sources for F2RL3 Gene

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