Aliases for F2RL3 Gene
External Ids for F2RL3 Gene
Previous GeneCards Identifiers for F2RL3 Gene
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
GeneCards Summary for F2RL3 Gene
F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3) is a Protein Coding gene. Diseases associated with F2RL3 include hepatocellular carcinoma. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include thrombin receptor activity. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for F2RL3 Gene
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling. Four subtypes of receptors have so far been cloned (PAR1-4). PAR4 tissue distribution is different from other PAR family members, with highest levels detected in the lung, pancreas, thyroid and testes. This receptor is localized to human chromosome 19p12. PAR4 is sensitive to both alpha- and gamma-thrombin, yet has a low affinity for the peptide. PAR4 therefore may function as a low affinity thrombin receptor that is activated at conditions where high concentrations of thrombin are achieved. This receptor helps to sustain platelet aggregation during prolonged thrombin exposure, as unlike PAR1, it is slowly inactivated.