Aliases for F2RL2 Gene
External Ids for F2RL2 Gene
Previous GeneCards Identifiers for F2RL2 Gene
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
GeneCards Summary for F2RL2 Gene
F2RL2 (Coagulation Factor II Thrombin Receptor Like 2) is a Protein Coding gene. Diseases associated with F2RL2 include Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. Among its related pathways are ADP signalling through P2Y purinoceptor 1 and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include G-protein coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.
UniProtKB/Swiss-Prot for F2RL2 Gene
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.