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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F2RL2 Gene

protein-coding   GIFtS: 59
GCID: GC05M075947

Coagulation Factor II (Thrombin) Receptor-Like 2

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coagulation Factor II (Thrombin) Receptor-Like 21 2     Coagulation Factor II Receptor-Like 2 (Protease-Actovated Receptor 3)2
PAR32 3 5     Protease-Activated Receptor 32
Proteinase-Activated Receptor-31 2     Proteinase-Activated Receptor 32
Thrombin Receptor-Like 22 3     Coagulation Factor II Receptor-Like 23
PAR-32 3     

External Ids:    HGNC: 35391   Entrez Gene: 21512   Ensembl: ENSG000001642207   OMIM: 6019195   UniProtKB: O002543   

Export aliases for F2RL2 gene to outside databases

Previous GC identifers: GC05M074718 GC05M076147 GC05M075951 GC05M075995 GC05M071119


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F2RL2 Gene:
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven
transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the
thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded
protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript
variants that encode different isoforms. (provided by RefSeq, Feb 2012)

GeneCards Summary for F2RL2 Gene: 
F2RL2 (coagulation factor II (thrombin) receptor-like 2) is a protein-coding gene. Diseases associated with F2RL2 include erythema multiforme, and achondroplasia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and thrombin receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254
Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis

Gene Wiki entry for F2RL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F2RL2 gene promoter:
         AML1a   AP-1   GR-beta   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GR-alpha   c-Jun   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF2RL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for F2RL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F2RL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13

F2RL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2RL2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M075947:  view genomic region     (about GC identifiers)

Start:
75,911,307 bp from pter      End:
75,919,259 bp from pter
Size:
7,953 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254 (See protein sequence)
Recommended Name: Proteinase-activated receptor 3 precursor  
Size: 374 amino acids; 42508 Da
Subunit: Interacts with INSC/inscuteable and probably GPSM2
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAD97628.1; Type=Frameshift; Positions=374;
Secondary accessions: B2R754 B4DQ13 Q52M68 Q7Z3W3
Alternative splicing: 2 isoforms:  O00254-1   O00254-2   

Explore the universe of human proteins at neXtProt for F2RL2: NX_O00254

Explore proteomics data for F2RL2 at MOPED 

Post-translational modifications:

  • UniProtKB: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00254

  • F2RL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    F2RL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243495.1  NP_004092.1  

    ENSEMBL proteins: 
     ENSP00000296641   ENSP00000426703  
    Reactome Protein details: O00254
    Human Recombinant Protein Products for F2RL2: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9087410
    GO:0016021integral to membrane ----
    GO:0016324apical plasma membrane IEA--

    F2RL2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    F2R: GPCR / Class A : Protease activated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAR3 
    Protease-activated receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003943 Prot_act_rcpt_3
     IPR003912 Protea_act_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O00254

    ProtoNet protein and cluster: O00254

    2 Blocks protein domains:
    IPB003912 Protease activated receptor precursor signature
    IPB003943 Protease activated receptor 3 precursor signature


    UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254
    Similarity: Belongs to the G-protein coupled receptor 1 family


    F2RL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR3_HUMAN, O00254
    Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis

         Genatlas biochemistry entry for F2RL2:
    coagulation factor II (thrombin) receptor-like 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS9087410
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI17474147
    GO:0015057thrombin receptor activity IEA--
         
    F2RL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for F2rl2):
     hematopoietic system  homeostasis/metabolism 

    F2RL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out F2rl2tm1Cgh for F2RL2

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for F2RL2 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Thromboxane signalling through TP receptor
    Thrombin signalling through proteinase activated receptors (PARs)0.67

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for F2RL2
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F2RL2
        G12-G13 in Cellular Signaling
    JAK-STAT Pathway
    Thrombin Signaling

    5/7 BioSystems Pathways for F2RL2 (see all 7)
        GPCRs, Class A Rhodopsin-like
    CDC42 signaling events
    Insulin Pathway
    ErbB1 downstream signaling
    Nephrin/Neph1 signaling in the kidney podocyte

    5/11        Reactome Pathways for F2RL2 (see all 11)
        GPCR downstream signaling
    Hemostasis
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for F2RL2):
        Neuroactive ligand-receptor interaction


    F2RL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F2RL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for F2RL2 (O002541, 2, 3 ENSP000002966414) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INADLQ8NI352, 3, ENSP000003602004MINT-4300898 MINT-4300885 I2D: score=1 STRING: ENSP00000360200
    ABL1P005192, 3, ENSP000003614234MINT-8110623 I2D: score=3 STRING: ENSP00000361423
    PLCG1P191742, 3, ENSP000002440074MINT-8112675 I2D: score=3 STRING: ENSP00000244007
    SRCP129312, 3, ENSP000003509414MINT-8113179 I2D: score=3 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-1751853,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007596blood coagulation TAS--
    GO:0009611response to wounding TAS9087410
    GO:0030168platelet activation TAS--

    F2RL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F2RL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for F2RL2 (PAR3)

    10/17 Novoseek inferred chemical compound relationships for F2RL2 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 64.1 2 17968879 (1), 14613291 (1)
    ketanserin 30.4 2 16481292 (1), 12887773 (1)
    ondansetron 28.5 3 8347903 (1), 8372610 (1), 9283717 (1)
    calcium 23.7 5 15317288 (1), 18264801 (1), 14515192 (1), 10831593 (1)
    dmso 22.5 2 19188088 (1)
    rantes 20.8 1 12176812 (1)
    5-hydroxytryptamine 20.1 3 18254974 (1), 8372610 (1)
    vegf 19.4 3 18519586 (1), 20004943 (1), 17164762 (1)
    tyrosine 16.6 4 2019259 (1), 7798258 (1), 17047157 (1), 16525676 (1)
    pge2 14.7 1 15519499 (1)

    Search CenterWatch for drugs/clinical trials and news about F2RL2 / PAR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for F2RL2 gene (2 alternative transcripts): 
    NM_001256566.1  NM_004101.3  

    Unigene Cluster for F2RL2:

    Coagulation factor II (thrombin) receptor-like 2
    Hs.42502  [show with all ESTs]
    Unigene Representative Sequence: NM_004101
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296641(uc011csw.2 uc003kem.3) ENST00000504899
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK298585.1 AK312848.1 BC093648.1 BC093650.1 BC095499.1 BX537386.1 U92971.1 

    4 DOTS entries:

    DT.87015130  DT.443472  DT.120839145  DT.95265413 

    24/40 AceView cDNA sequences (see all 40):

    AA983803 AL048675 U92971 NM_004101 AL713459 AA570482 H98551 CF126741 
    N26732 BX474658 BM989640 BX537386 H98544 BX102060 AW973423 AI131231 
    AI378647 CN834303 H98537 CN837623 CN836476 AA041482 H98520 AA483486 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F2RL2 expression in normal human tissues (normalized intensities)      F2RL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCACTACG
    F2RL2 Expression
    About this image


    F2RL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human umbilical vein endothelial cells (HUVEC)
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Fetal Liver Stromal Cells   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Wharton's jelly-derived stem cells
     
     Smooth Muscle (Muscoskeletal System)
             Human Tracheal Smooth Muscle Cells (HTSMC)   

    See F2RL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F2RL2

    SOURCE GeneReport for Unigene cluster: Hs.42502

    UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254
    Tissue specificity: Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes,
    in platelets and in a variety of other tissues such as heart and gut

        SABiosciences Expression via Pathway-Focused PCR Array including F2RL2: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for F2RL2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F2rl21 , 5 coagulation factor II (thrombin) receptor-like 21, 5 77.26(n)1
    71.82(a)1
      13 (50.38 cM)5
    140641  NM_010170.41  NP_034300.31 
     956968535 
    chicken
    (Gallus gallus)
    Aves F2RL21 coagulation factor II (thrombin) receptor-like 2 65.29(n)
    62.64(a)
      768449  XM_001231245.2  XP_001231246.1 
    lizard
    (Anolis carolinensis)
    Reptilia F2RL26
    Uncharacterized protein
    55(a)
    1 ↔ 1
    2(14263666-14266547)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003332651 proteinase-activated receptor 3-like 49.35(n)
    41.5(a)
      100333265  XM_002665869.1  XP_002665915.1 


    ENSEMBL Gene Tree for F2RL2 (if available)
    TreeFam Gene Tree for F2RL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F2RL2 gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  GPR422  
    GPR1322  FFAR12  F2RL32  F2R2  
    18/20 SIMAP similar genes for F2RL2 using alignment to 2 protein entries:     PAR3_HUMAN (see all proteins) (see all similar genes):
    GPR18    F2RL1    CMKLR1    F2RL3    P2RY8    LPAR6
    P2RY5    F2R    OXGR1    GPR87    GPR17    LPAR4
    P2RY1    CYSLTR1    CYSLTR2    GIR    GPR183    KPG_011

    F2RL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in F2RL2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0128514
    ----see VAR_0128512 N D mis40--------
    VAR_0128494
    ----see VAR_0128492 L S mis40--------
    VAR_0128504
    ----see VAR_0128502 M V mis40--------

    HapMap Linkage Disequilibrium report for F2RL2 (75911307 - 75919259 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for F2RL2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing F2RL2
    DNA2.0 Custom Variant and Variant Library Synthesis for F2RL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601919    OMIM disorders: --

    20/27 diseases for F2RL2 (see all 27):    About MalaCards
    erythema multiforme    achondroplasia    toxic epidermal necrolysis    stevens-johnson syndrome
    dwarfism    thrombosis    gigantism    hyperhomocysteinemia
    dermatomyositis    gingivitis    schizophrenia    rhabdomyosarcoma
    coronary heart disease    hepatocellular carcinoma    renal cell carcinoma    ovarian cancer
    endotheliitis    hypertension    rheumatoid arthritis    arthritis


    F2RL2 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for F2RL2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    achondroplasia 48.5 2 12361605 (1), 15863034 (1)
    inflammation 31.8 2 17376866 (1)
    dwarfism 26.4 2 12361605 (1), 15863034 (1)
    erythroleukemia 17.8 3 15504554 (2)
    tumors 8.54 11 19513616 (3), 18623079 (1), 19454271 (1), 17308070 (1) (see all 6)
    necrosis 3.9 7 14623878 (1), 15491417 (1), 9614115 (1), 16965421 (1)
    schizophrenia 0 1 20356718 (1)
    hepatocellular carcinoma 0 1 17323377 (1)
    adenocarcinoma 0 1 15800658 (1)
    metastasis 0 3 20442298 (2), 19513616 (1)

    Genetic Association Database (GAD): F2RL2
    Human Genome Epidemiology (HuGE) Navigator: F2RL2 (3 documents)

    Export disorders for F2RL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F2RL2 gene, integrated from 9 sources (see all 199):
    (articles sorted by number of sources associating them with F2RL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protease-activated receptor 3 is a second thrombin receptor in humans. (PubMed id 9087410)1, 2, 3, 9 Ishihara H.... Coughlin S.R. (1997)
    2. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets. (PubMed id 9614115)1, 2, 9 Schmidt V.A.... Bahou W.F. (1998)
    3. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 2, 9 Kahn M.L....Coughlin S.R. (1999)
    4. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)1, 3, 9 Kahn M.L....Coughlin S.R. (1998)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. A genome-wide association study for age-related heari ng impairment in the Saami. (PubMed id 20068591)1, 4 Van Laer L....Van Camp G. (2010)
    7. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)1, 2 Izaki T.... Sumimoto H. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells. (PubMed id 15504554)1, 9 Cupit L.D....Bahou W.F. (2004)
    10. Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. (PubMed id 11307827)1, 9 Cumashi A....Molino M. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2151 HGNC: 3539 AceView: F2RL2 Ensembl:ENSG00000164220 euGenes: HUgn2151
    ECgene: F2RL2 Kegg: 2151 H-InvDB: F2RL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F2RL2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/f2rl2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for F2RL2 gene:
    Search GeneIP for patents involving F2RL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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