F2RL2 Gene

Aliases
for F2RL2 gene

Previous GC identifers: GC05M074718 GC05M076147 GC05M075951 GC05M075995 GC05M071119

Summaries
for F2RL2 gene

Genomic Views
for F2RL2 gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_006713.15  

SwitchGear Promoter luciferase reporter plasmid: F2RL2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F2RL2

F2RL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M075947:  view genomic region     (about GC identifiers)

Proteins
for F2RL2 gene

Explore the universe of human proteins at neXtProt for F2RL2: NX_O00254

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: F2RL2 OriGene Custom Protein Services for F2RL2
	GenScript Custom Purified and Recombinant Proteins Services for F2RL2
	Novus Biologicals F2RL2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for F2RL2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of F2RL2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for F2RL2
	GenScript Custom Superior Antibodies Services for F2RL2
	Novus Biologicals F2RL2 Antibody
	Search for Antibodies for F2RL2 at Abcam
	Uscn Antibodies for F2RL2
	Search ThermoFisher Antibodies for F2RL2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for F2RL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for F2RL2

Protein Domains /
Families
for F2RL2 gene

ProtoNet protein and cluster: O00254

Function
for F2RL2 gene

miRNA Products:		OriGene 3'-UTR Clone: F2RL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat F2RL2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate F2RL2 (see all 9):
		hsa-miR-34c-5p hsa-miR-3140-3p hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-2117 hsa-miR-1827 hsa-miR-580
		SwitchGear 3'UTR luciferase reporter plasmid: F2RL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for F2RL2 (see all 7) OriGene shRNA RFP: F2RL2 OriGene siRNA: F2RL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat F2RL2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for F2RL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F2RL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for F2RL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: F2RL2 (NM_004101)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for F2RL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F2RL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for F2RL2
		Search LifeMap BioReagents cell lines for F2RL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F2RL2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for F2rl2)

Pathways & Interactions
for F2RL2 gene

	Super-pathway	contained gene-specific pathways
1	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 GPCRs, Class A Rhodopsin-like 0.41 GPCR ligand binding 0.75 Neuroactive ligand-receptor interaction 0.38 Peptide ligand-binding receptors 0.61
2	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
3	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation 1.00 Hemostasis 0.43
4	G alpha (q) signalling events	G alpha (q) signalling events 1.00 Gastrin-CREB signalling pathway via PKC and MAPK 0.90
5	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q 1.00

1 EMD Millipore Pathway for F2RL2

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F2RL2

	G12-G13 in Cellular Signaling
	JAK-STAT Pathway
	Thrombin Signaling

5/7 BioSystems Pathways for F2RL2

	GPCRs, Class A Rhodopsin-like
	CDC42 signaling events
	RhoA signaling pathway
	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
	Insulin Pathway

5/11        Reactome Pathways for F2RL2

	GPCR downstream signaling
	Hemostasis
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR

1         Kegg Pathway  (Kegg details for F2RL2)

Neuroactive ligand-receptor interaction

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for F2RL2 gene

Transcripts
for F2RL2 gene

Expression
for F2RL2 gene

F2RL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCACTACG

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 7 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ progenitor E68 (Embryonic Progenitor Cell)
	PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)			Lateral Plate Mesoderm, Neural Crest
	PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
	PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
	Embryoid bodies (Two-step protocol fo...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for F2RL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat F2RL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F2RL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F2RL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F2RL2

Orthologs
for F2RL2 gene

Paralogs
for F2RL2 gene

Paralogs for F2RL2 gene

GPR4²  FFAR3²  GPR68²  P2RY8²  F2RL1²  GPR65²  FFAR2²  GPR132²  

FFAR1²  GPR42²  F2RL3²  F2R²  

18/20 SIMAP similar genes for F2RL2 using alignment to 2 protein entries:     PAR3_HUMAN (see all proteins) (see all similar genes):

GPR18    F2RL1    CMKLR1    F2RL3    P2RY8    LPAR6

P2RY5    F2R    OXGR1    GPR87    GPR17    LPAR4

P2RY1    CYSLTR1    CYSLTR2    GIR    GPR183    KPG_011

F2RL2 for paralogs           About GeneDecksing

Genomic Variants
for F2RL2 gene

10/236 NCBI SNPs in F2RL2 are shown (see all 236)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1828830111,2		--	75910951(+)	GTGGTA/GTGTGC	3	--	ds5001 int1		0	--	--	--	--
rs22920191,2	C,F,H,	--	75910986(-)	ATATGT/CTCACA	3	--	ds5001 int1		9		EA NS WA CSA	2146
rs20696961,2	C,F,	--	75911029(-)	ATATAC/AAAGGA	3	--	ds5001 int1		3		NS WA	212
rs20696951,2	F	--	75911046(-)	AAAAGCA/-CACAG	3	--	int1 ds5001		2		NS	94
rs1449951161,2		--	75911224(+)	ATAAC-/CACACAC	3	--	ds5001 int1		0	--	--	--	--
rs1868367671,2		--	75911253(+)	CATGTA/GGAAGC	3	--	ds5001 int1		0	--	--	--	--
rs10475301,2	C,F,	--	75911399(-)	AAAAGA/GTTCCT	3	--	int1 ut31 ese3		17		NS EA MN NA WA	2778
rs1917696211,2		--	75911452(+)	ATTCAC/TTCTTT	3	--	ut31 int1		0	--	--	--	--
rs1827541021,2		--	75911454(+)	TCACTC/TTTTAC	3	--	int1 ut31		0	--	--	--	--
rs10475291,2	C,F,H,	--	75911464(-)	GATATG/TAGTGG	3	--	ut31 int1 ese3		32		EA NA MN NS WA	4572

HapMap Linkage Disequilibrium report for F2RL2 (75911307 - 75919259 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for F2RL2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing F2RL2

DNA2.0 Custom Variant and Variant Library Synthesis for F2RL2

Disorders / Diseases
for F2RL2 gene

20/28 diseases for F2RL2

10/14 Novoseek disease relationships for F2RL2 gene (see all 14)    About this table

Publications
for F2RL2 gene

PubMed articles for F2RL2 gene, integrated from 9 sources (see all 196): (articles sorted by number of sources associating them with F2RL2)

Utopia: connect your pdf to the dynamic world of online information

1. Protease-activated receptor 3 is a second thrombin receptor in humans. (PubMed id 9087410)^{1, 2, 3, 9} Ishihara H.... Coughlin S.R. (1997)
2. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets. (PubMed id 9614115)^{1, 2, 9} Schmidt V.A.... Bahou W.F. (1998)
3. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)^{1, 2, 9} Kahn M.L....Coughlin S.R. (1999)
4. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)^{1, 3, 9} Kahn M.L....Coughlin S.R. (1998)
5. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)^{1, 2} Izaki T.... Sumimoto H. (2006)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells. (PubMed id 15504554)^{1, 9} Cupit L.D....Bahou W.F. (2004)
8. Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. (PubMed id 11307827)^{1, 9} Cumashi A....Molino M. (2001)
9. Evidence for functionally active protease-activated receptor-3 (PAR-3) in human vascular smooth muscle cells. (PubMed id 14515192)^{1, 9} Bretschneider E....Schror K. (2003)
10. PAR-3 is a low-affinity substrate, high affinity effector of thrombin. (PubMed id 12732212)^{1, 9} Owen W.G. (2003)

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Products
for F2RL2 gene