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F2RL2 Gene

protein-coding   GIFtS: 59
GCID: GC05M075947

Coagulation Factor II (Thrombin) Receptor-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coagulation Factor II (Thrombin) Receptor-Like 21 2     Coagulation Factor II Receptor-Like 2 (Protease-Actovated Receptor 3)2
PAR32 3 5     Protease-Activated Receptor 32
Proteinase-Activated Receptor-31 2     Proteinase-Activated Receptor 32
Thrombin Receptor-Like 22 3     Coagulation Factor II Receptor-Like 23
PAR-32 3     

External Ids:    HGNC: 35391   Entrez Gene: 21512   Ensembl: ENSG000001642207   OMIM: 6019195   UniProtKB: O002543   

Export aliases for F2RL2 gene to outside databases

Previous GC identifers: GC05M074718 GC05M076147 GC05M075951 GC05M075995 GC05M071119


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for F2RL2 Gene:
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven
transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the
thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded
protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript
variants that encode different isoforms. (provided by RefSeq, Feb 2012)

GeneCards Summary for F2RL2 Gene:
F2RL2 (coagulation factor II (thrombin) receptor-like 2) is a protein-coding gene. Diseases associated with F2RL2 include achondroplasia, and erythema multiforme. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and thrombin receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254
Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis

Gene Wiki entry for F2RL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the F2RL2 gene promoter:
         AML1a   AP-1   GR-beta   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GR-alpha   c-Jun   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF2RL2 promoter sequence
   Search Chromatin IP Primers for F2RL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F2RL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13

F2RL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2RL2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M075947:  view genomic region     (about GC identifiers)

Start:
75,911,307 bp from pter      End:
75,919,259 bp from pter
Size:
7,953 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254 (See protein sequence)
Recommended Name: Proteinase-activated receptor 3 precursor  
Size: 374 amino acids; 42508 Da
Subunit: Interacts with INSC/inscuteable and probably GPSM2
Sequence caution: Sequence=CAD97628.1; Type=Frameshift; Positions=374;
Secondary accessions: B2R754 B4DQ13 Q52M68 Q7Z3W3
Alternative splicing: 2 isoforms:  O00254-1   O00254-2   

Explore the universe of human proteins at neXtProt for F2RL2: NX_O00254

Post-translational modifications: 

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand1
  • Glycosylation2 at Asn25, Asn82, Asn331
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_001243495.1  NP_004092.1  

    ENSEMBL proteins: 
     ENSP00000296641   ENSP00000426703  
    Reactome Protein details: O00254

    F2RL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    F2R: GPCR / Class A : Protease activated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAR3
    Protease-activated receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003943 Prot_act_rcpt_3
     IPR003912 Protea_act_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O00254

    ProtoNet protein and cluster: O00254

    2 Blocks protein domains:
    IPB003912 Protease activated receptor precursor signature
    IPB003943 Protease activated receptor 3 precursor signature


    UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254
    Similarity: Belongs to the G-protein coupled receptor 1 family


    F2RL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR3_HUMAN, O00254
    Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis

         Genatlas biochemistry entry for F2RL2:
    coagulation factor II (thrombin) receptor-like 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS9087410
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI17474147
    GO:0015057thrombin receptor activity IEA--
         
    F2RL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for F2rl2):
     hematopoietic system  homeostasis/metabolism 

    F2RL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out F2rl2tm1Cgh for F2RL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for F2RL2
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    miRNA
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    hsa-miR-34c-5p hsa-miR-3140-3p hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-2117 hsa-miR-1827 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidF2RL2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAR3_HUMAN, O00254: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9087410
    GO:0016021integral component of membrane ----
    GO:0016324apical plasma membrane IEA--

    F2RL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for F2RL2 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5ADP signalling through P2Y purinoceptor 12
    Thrombin signalling through proteinase activated receptors (PARs)0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F2RL2
        G12-G13 in Cellular Signaling
    JAK-STAT Pathway
    Thrombin Signaling

    Selected BioSystems Pathways for F2RL2 (see all 7)
        GPCRs, Class A Rhodopsin-like
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    CDC42 signaling events
    Nephrin/Neph1 signaling in the kidney podocyte
    Insulin Pathway

    3 Reactome Pathways for F2RL2
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    Thrombin signalling through proteinase activated receptors (PARs)


    1 Kegg Pathway  (Kegg details for F2RL2):
        Neuroactive ligand-receptor interaction


    F2RL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including F2RL2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for F2RL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for F2RL2 (O002541, 2, 3 ENSP000002966414) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INADLQ8NI352, 3, ENSP000003602004MINT-4300898 MINT-4300885 I2D: score=1 STRING: ENSP00000360200
    ABL1P005192, 3, ENSP000003614234MINT-8110623 I2D: score=3 STRING: ENSP00000361423
    PLCG1P191742, 3, ENSP000002440074MINT-8112675 I2D: score=3 STRING: ENSP00000244007
    SRCP129312, 3, ENSP000003509414MINT-8113179 I2D: score=3 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-1751853,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007596blood coagulation TAS--
    GO:0008152metabolic process TAS9087410
    GO:0009611response to wounding TAS9087410
    GO:0030168platelet activation TAS--

    F2RL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for F2RL2 (PAR3)

    Selected Novoseek inferred chemical compound relationships for F2RL2 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcma 64.1 2 17968879 (1), 14613291 (1)
    ketanserin 30.4 2 16481292 (1), 12887773 (1)
    ondansetron 28.5 3 8347903 (1), 8372610 (1), 9283717 (1)
    calcium 23.7 5 15317288 (1), 18264801 (1), 14515192 (1), 10831593 (1)
    dmso 22.5 2 19188088 (1)
    rantes 20.8 1 12176812 (1)
    5-hydroxytryptamine 20.1 3 18254974 (1), 8372610 (1)
    vegf 19.4 3 18519586 (1), 20004943 (1), 17164762 (1)
    tyrosine 16.6 4 2019259 (1), 7798258 (1), 17047157 (1), 16525676 (1)
    pge2 14.7 1 15519499 (1)



    F2RL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for F2RL2 gene (2 alternative transcripts): 
    NM_001256566.1  NM_004101.3  

    Unigene Cluster for F2RL2:

    Coagulation factor II (thrombin) receptor-like 2
    Hs.42502  [show with all ESTs]
    Unigene Representative Sequence: NM_004101
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296641(uc011csw.2 uc003kem.3) ENST00000504899
    miRNA
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    Additional mRNA sequence: 

    AK298585.1 AK312848.1 BC093648.1 BC093650.1 BC095499.1 BX537386.1 U92971.1 

    4 DOTS entries:

    DT.87015130  DT.443472  DT.120839145  DT.95265413 

    Selected AceView cDNA sequences (see all 40):

    AL048675 AA983803 U92971 NM_004101 AI131231 H98544 N26732 AI378647 
    BM989640 BX102060 AA570482 AW973423 AL713459 H98551 CF126741 BX474658 
    BX537386 CN834303 AA483486 H98520 H98537 N24954 CN836476 AA041482 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    F2RL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCACTACG
    F2RL2 Expression
    About this image


    F2RL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    F2RL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.42502

    UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254
    Tissue specificity: Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes,
    in platelets and in a variety of other tissues such as heart and gut

        Pathway & Disease-focused RT2 Profiler PCR Array including F2RL2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F2RL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for F2RL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F2rl21 , 5 coagulation factor II (thrombin) receptor-like 21, 5 77.24(n)1
    71.43(a)1
      13 (50.38 cM)5
    140641  NM_010170.41  NP_034300.31 
     956968535 
    chicken
    (Gallus gallus)
    Aves F2RL21 coagulation factor II (thrombin) receptor-like 2 66.76(n)
    63.77(a)
      768449  XM_001231245.3  XP_001231246.1 
    lizard
    (Anolis carolinensis)
    Reptilia F2RL26
    coagulation factor II (thrombin) receptor-like 2
    55(a)
    1 ↔ 1
    2(14263666-14266547)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia f2rl21 coagulation factor II (thrombin) receptor-like 2 61.77(n)
    53.03(a)
      734095  NM_001045769.1  NP_001039234.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003332651 proteinase-activated receptor 3-like 48.75(n)
    41.04(a)
      100333265  XM_002665869.2  XP_002665915.2 


    ENSEMBL Gene Tree for F2RL2 (if available)
    TreeFam Gene Tree for F2RL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for F2RL2 gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  GPR422  
    GPR1322  FFAR12  F2RL32  F2R2  
    Selected SIMAP similar genes for F2RL2 using alignment to 2 protein entries:     PAR3_HUMAN (see all proteins) (see all similar genes):
    GPR18    F2RL1    CMKLR1    F2RL3    P2RY8    LPAR6
    F2R    OXGR1    GPR87    GPR17    LPAR4    P2RY1
    CYSLTR1    CYSLTR2    GIR    GPR183    KPG_011    CXCR1

    F2RL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for F2RL2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20696831,2,4
    ----see VAR_0128512 mis40--------
    rs20696491,2,4
    ----see VAR_0128492 mis40--------
    rs20697001,2,4
    ----see VAR_0128502 mis40--------

    HapMap Linkage Disequilibrium report for F2RL2 (75911307 - 75919259 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for F2RL2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing F2RL2
    DNA2.0 Custom Variant and Variant Library Synthesis for F2RL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601919    OMIM disorders: --

    Selected diseases for F2RL2 (see all 27):    
    About MalaCards
    achondroplasia    erythema multiforme    dwarfism    stevens-johnson syndrome
    toxic epidermal necrolysis    gigantism    hyperhomocysteinemia    dermatomyositis
    gingivitis    ovarian cancer    schizophrenia    coronary heart disease
    rhabdomyosarcoma    hepatocellular carcinoma    renal cell carcinoma    endotheliitis
    hypertension    rheumatoid arthritis    arthritis    melanoma


    F2RL2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for F2RL2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    achondroplasia 48.5 2 12361605 (1), 15863034 (1)
    inflammation 31.8 2 17376866 (1)
    dwarfism 26.4 2 12361605 (1), 15863034 (1)
    erythroleukemia 17.8 3 15504554 (2)
    tumors 8.54 11 19513616 (3), 18623079 (1), 19454271 (1), 17308070 (1) (see all 6)
    necrosis 3.9 7 14623878 (1), 15491417 (1), 9614115 (1), 16965421 (1)
    schizophrenia 0 1 20356718 (1)
    hepatocellular carcinoma 0 1 17323377 (1)
    adenocarcinoma 0 1 15800658 (1)
    metastasis 0 3 20442298 (2), 19513616 (1)

    Genetic Association Database (GAD): F2RL2
    Human Genome Epidemiology (HuGE) Navigator: F2RL2 (3 documents)

    Export disorders for F2RL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for F2RL2 gene, integrated from 10 sources (see all 200):
    (articles sorted by number of sources associating them with F2RL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protease-activated receptor 3 is a second thrombin receptor in humans. (PubMed id 9087410)1, 2, 3, 9 Ishihara H.... Coughlin S.R. (Nature 1997)
    2. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets. (PubMed id 9614115)1, 2, 9 Schmidt V.A.... Bahou W.F. (J. Biol. Chem. 1998)
    3. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 2, 9 Kahn M.L....Coughlin S.R. (J. Clin. Invest. 1999)
    4. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)1, 3, 9 Kahn M.L.... Coughlin S.R. (J. Biol. Chem. 1998)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. A genome-wide association study for age-related hearing impairment in the Saami. (PubMed id 20068591)1, 4 Van Laer L....Van Camp G. (Eur. J. Hum. Genet. 2010)
    7. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)1, 2 Izaki T.... Sumimoto H. (Biochem. Biophys. Res. Commun. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells. (PubMed id 15504554)1, 9 Cupit L.D....Bahou W.F. (Exp. Hematol. 2004)
    10. Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. (PubMed id 11307827)1, 9 Cumashi A....Molino M. (Thromb. Haemost. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2151 HGNC: 3539 AceView: F2RL2 Ensembl:ENSG00000164220 euGenes: HUgn2151
    ECgene: F2RL2 Kegg: 2151 H-InvDB: F2RL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for F2RL2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/f2rl2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for F2RL2 gene:
    Search GeneIP for patents involving F2RL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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