 |
 | Services
| |
 |
Aliases & Descriptions for F2RL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| PAR-3 3 | | PAR3 1, 2, 3, 5 |
| | | Descriptions |
|---|
| Coagulation factor II receptor-like 2 3 | Coagulation factor II receptor-like 2 (protease-actovated receptor 3) 2 | | Thrombin receptor-like 2 2, 3 | | coagulation factor II (thrombin) receptor-like 2 2 | | protease-activated receptor 3 2 | | proteinase-activated receptor-3 2 |
|
| | Search outside databases for aliases for F2RL2 genePrevious GC identifers: GC05M074718 GC05M076147 GC05M075951 GC05M075995 |
Summaries for F2RL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for F2RL2: Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues. [provided by RefSeq] UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysisGene Wiki entry for F2RL2 |
Genomic Location for F2RL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the F2RL2 gene 
Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13F2RL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M075947:
(about GC identifiers)
Start:
|
75,947,063 bp from pter |
End:
|
75,954,996 bp from pter |
Size:
|
7,934 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000005.8 NT_006713.14
| Proteins for F2RL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254 (See
protein sequence)Recommended Name: Proteinase-activated receptor 3 precursor Size: 374 amino acids; 42508 Da
Subunit: Interacts with INSC/inscuteable and probably GPSM2
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q52M68Post-translational modifications:
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand1
REFSEQ proteins: NP_004092.1
ENSEMBL proteins: ENSP00000296641
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for F2RL2: Assays for F2RL2: | Protein
Domains/ Families for F2RL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O00254
ProtoNet protein and cluster: O00254 2 Blocks protein families: IPB003912 Protease activated receptor precursor signature IPB003943 Protease activated receptor 3 precursor signature
UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for F2RL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004101
Applied Biosystems Silencer® siRNAs for F2RL2
Sigma-Aldrich siRNA and siRNA Panels for F2RL2  Sigma-Aldrich shRNA Panels and shRNA for F2RL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004101                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004101                                  untagged cDNA clone in CMV expression vector: NM_004101 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004101
UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254Function: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysisGenatlas biochemistry entry for F2RL2:coagulation factor II (thrombin) receptor-like 2,G protein coupled receptor superfamily2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for F2rl2):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for F2RL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for F2RL2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for F2RL2 
5/8 Interacting proteins for F2RL2 (O002541, 2) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for F2RL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for F2RL2 |
Compounds for F2RL2 available from Tocris Bioscience 8 Novoseek chemical compound relationships for F2RL2 gene
About this table
|
Transcripts for F2RL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004101
Sigma-Aldrich siRNA and siRNA Panels for F2RL2  Sigma-Aldrich shRNA Panels and shRNA for F2RL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004101 REFSEQ mRNAs for F2RL2 gene: NM_004101.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004101               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004101                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004101                                  untagged cDNA clone in CMV expression vector: NM_004101  Additional cDNA sequence: AK298585.1 AK312848.1 BC093648.1 BC093650.1 BC095499.1 BX537386.1 U92971.1 4 DOTS entries: DT.87015130 DT.443472 DT.120839145 DT.95265413 24/40 AceView cDNA sequences (see all 40
):NM_004101 AA983803 U92971 AL048675 CF126741 H98544 AA570482 N26732 AW973423 AI131231 H98551 BX537386 BX474658 AI378647 BX102060 AL713459 BM989640 CN834303 H98537 H98520 AA483486 CN836476 AA041482 N34619
highest scoring ESTs for F2RL2:U92971 AI378647 AL713459 BX474658 BX537386 CN833866 CN834303 CN836476 CN837623 AA041482 Unigene Cluster for F2RL2: Coagulation factor II (thrombin) receptor-like 2 Hs.42502 [show with all ESTs]Unigene Representative Sequence: NM_004101
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000296641
|
Expression for F2RL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| F2RL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for F2RL2
1 / 2 / 3 7 probe-sets matching F2RL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGCCACTACG
SOURCE GeneReport for Unigene cluster: Hs.42502
Expression variation in blood from EXPOLDB for F2RL2 UniProtKB/Swiss-Prot: PAR3_HUMAN, O00254Tissue specificity: Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut |
Orthologs for F2RL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for F2RL2 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for F2RL2
ENSEMBL Gene Tree for F2RL2 | Paralogs for F2RL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for F2RL2 gene
- P2RY82 GPR182 F2RL12 F2RL32 F2R2
|
SNPs/Variants for F2RL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations for F2RL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601919
10/12 Novoseek disease relationships for F2RL2 gene (see all 12
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| achondroplasia |
50.01 |
2 |
12361605 (1), 15863034 (1) |
| inflammation |
31.00 |
2 |
17376866 (1) |
| dwarfism |
28.78 |
2 |
12361605 (1), 15863034 (1) |
| erythroleukemia |
19.50 |
3 |
15504554 (2) |
| necrosis |
6.92 |
7 |
14623878 (1), 15491417 (1), 9614115 (1), 16965421 (1) |
| cancer |
0.00 |
2 |
17114345 (1), 17164762 (1) |
| carcinoma |
0.00 |
3 |
11743661 (1), 15582715 (1) |
| tumors |
0.00 |
5 |
18623079 (1), 14623878 (1), 9614115 (1), 17308070 (1) |
| hepatocellular carcinoma |
0.00 |
1 |
17323377 (1) |
| adenocarcinoma |
0.00 |
1 |
15800658 (1) |
About this table
|
Medical News for F2RL2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for F2RL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/158 PubMed articles for F2RL2 gene (see all 158
):- Protease-activated receptor 3 is a second thrombin receptor in humans. (PubMed id 9087410)1, 2, 3, 4 Ishihara H.... Coughlin S.R. (1997)
- The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets. (PubMed id 9614115)1, 3, 4 Schmidt V.A.... Bahou W.F. (1998)
- Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 3, 4 Kahn M.L....Coughlin S.R. (1999)
- Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PubMed id 9722561)1, 2, 3 Kahn M.L....Coughlin S.R. (1998)
- Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. (PubMed id 16458856)3, 4 Izaki T.... Sumimoto H. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Expression of protease activated receptor 3 (PAR3) is upregulated by induction of megakaryocyte phenotype in human erythroleukemia (HEL) cells. (PubMed id 15504554)1, 3 Cupit L.D....Bahou W.F. (2004)
- Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. (PubMed id 11307827)1, 3 Cumashi A....Molino M. (2001)
- Evidence for functionally active protease-activated receptor-3 (PAR-3) in human vascular smooth muscle cells. (PubMed id 14515192)1, 3 Bretschneider E....Schror K. (2003)
- PAR-3 is a low-affinity substrate, high affinity effector of thrombin. (PubMed id 12732212)1, 3 Owen W.G. (2003)
|
Search for F2RL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing F2RL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing F2RL2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing F2RL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| SeattleSNPs | http://pga.gs.washington.edu/data/f2rl2/ |
|
| | | About This Section
| --
| Services for F2RL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for F2RL2:

 | |
 | | | | |
|
 |  |  |
| | | | Tocris compounds for F2RL2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|