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Aliases for F2RL1 Gene

Aliases for F2RL1 Gene

  • Coagulation Factor II (Thrombin) Receptor-Like 1 2 3
  • GPR11 3 4 6
  • PAR2 3 4 6
  • Coagulation Factor II Receptor-Like 1 3 4
  • G-Protein Coupled Receptor 11 3 4
  • Thrombin Receptor-Like 1 3 4
  • Proteinase-Activated Receptor-2 2
  • Proteinase-Activated Receptor 2 3
  • Protease-Activated Receptor 2 3
  • PAR-2 4

External Ids for F2RL1 Gene

Previous HGNC Symbols for F2RL1 Gene

  • GPR11

Previous GeneCards Identifiers for F2RL1 Gene

  • GC05P074920
  • GC05P076349
  • GC05P076153
  • GC05P076198
  • GC05P076150
  • GC05P071322
  • GC05P076120

Summaries for F2RL1 Gene

Entrez Gene Summary for F2RL1 Gene

  • Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

GeneCards Summary for F2RL1 Gene

F2RL1 (Coagulation Factor II (Thrombin) Receptor-Like 1) is a Protein Coding gene. Diseases associated with F2RL1 include apert syndrome and pulmonary vein stenosis. Among its related pathways are Signaling by GPCR and p70S6K Signaling. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for F2RL1 Gene

  • Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

Tocris Summary for F2RL1 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling. Four subtypes of receptors have so far been cloned (PAR1-4). PAR2 is expressed in vascular tissue and highly vascular organs, which indicates a role for this receptor in the regulation of vascular tone. Trypsin is the endogenous agonist for PAR2 and receptor activation has been coupled to the nitric oxide signaling pathway, causing vasodilation and hypotension. PAR2 is implicated in chronic responses associated with vessel inflammation and wound healing. This receptor stimulates activation of T-cells and neutrophils, promotes leukocyte rolling, adhesion and extravasation, increases capillary permeability and enhances production of cytokines. In addition to its vascular roles, PAR2 has multiple functions in the gastrointestinal tract. It is strongly expressed in enterocytes and stimulates prostaglandin (PG) E2 and PGF1alpha synthesis. Pancreatic PAR2 expression and activation promotes secretory function, in particular increases amylin secretion.

Gene Wiki entry for F2RL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL1 Gene

Genomics for F2RL1 Gene

Regulatory Elements for F2RL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for F2RL1 Gene

Start:
76,818,933 bp from pter
End:
76,835,315 bp from pter
Size:
16,383 bases
Orientation:
Plus strand

Genomic View for F2RL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F2RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL1 Gene

Proteins for F2RL1 Gene

  • Protein details for F2RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55085-PAR2_HUMAN
    Recommended name:
    Proteinase-activated receptor 2
    Protein Accession:
    P55085
    Secondary Accessions:
    • Q13317
    • Q13346
    • Q53XJ8

    Protein attributes for F2RL1 Gene

    Size:
    397 amino acids
    Molecular mass:
    44126 Da
    Quaternary structure:
    • Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14 (By similarity).
    Miscellaneous:
    • Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling

neXtProt entry for F2RL1 Gene

Proteomics data for F2RL1 Gene at MOPED

Post-translational modifications for F2RL1 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14. Proposed subsequent cleaveage by serine proteases is leading to receptor deactivation and include neutrophil elastase and cathepsin G. At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference. In addition to conventional trypsin-like proteases is proposed to be activated by other proteases and glycosidases derived from bacteria, fungi and insects: serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13, Porphyromonas gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains, Streptomyces griseus exogenous chitinase, and an Alternaria alternata aspartate protease. Cleavage by the Alternaria alternata aspartate protease generates non-conventional processed forms.
  • Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation
  • Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.
  • N-glycosylated and sialylated.
  • Ubiquitination at Lys368
  • Glycosylation at Asn30, Thr45, Ser46, Thr49, Thr54, and Asn222
  • Modification sites at PhosphoSitePlus

Other Protein References for F2RL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for F2RL1 (F2RL1)

No data available for DME Specific Peptides for F2RL1 Gene

Domains for F2RL1 Gene

Gene Families for F2RL1 Gene

HGNC:
  • F2R :GPCR / Class A : Protease activated receptors
IUPHAR :

Suggested Antigen Peptide Sequences for F2RL1 Gene

Graphical View of Domain Structure for InterPro Entry

P55085

UniProtKB/Swiss-Prot:

PAR2_HUMAN :
  • P55085
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL1: view

Function for F2RL1 Gene

Molecular function for F2RL1 Gene

GENATLAS Biochemistry: coagulation factor II (thrombin) receptor proteinase-activated receptor 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

Gene Ontology (GO) - Molecular Function for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding ISS --
GO:0004872 receptor activity TAS 8615752
GO:0004930 G-protein coupled receptor activity ISS --
GO:0005102 receptor binding TAS 8615752
GO:0005515 protein binding IPI 15708858
genes like me logo Genes that share ontologies with F2RL1: view
genes like me logo Genes that share phenotypes with F2RL1: view

Animal Models for F2RL1 Gene

MGI Knock Outs for F2RL1:

Animal Model Products

CRISPR Products

miRNA for F2RL1 Gene

miRTarBase miRNAs that target F2RL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F2RL1

Clone Products

  • Addgene plasmids for F2RL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for F2RL1 Gene

Localization for F2RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F2RL1 Gene COMPARTMENTS Subcellular localization image for F2RL1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 2
cytoskeleton 1
cytosol 1
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 22547407
GO:0005794 Golgi apparatus TAS 8615752
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 17848177
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with F2RL1: view

Pathways for F2RL1 Gene

genes like me logo Genes that share pathways with F2RL1: view

Pathways by source for F2RL1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response ISS --
GO:0002690 positive regulation of leukocyte chemotaxis IDA 17991872
GO:0002741 positive regulation of cytokine secretion involved in immune response IDA 11441110
GO:0003104 positive regulation of glomerular filtration ISS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with F2RL1: view

Compounds for F2RL1 Gene

(5) Tocris Compounds for F2RL1 Gene

Compound Action Cas Number
SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist [1216720-69-2]
SLIGKV-NH2 PAR2 receptor agonist [190383-13-2]
SLIGRL-NH2 PAR2-activating peptide [171436-38-7]
tcY-NH2 Selective PAR4 antagonist [327177-34-4]
TRAP-6 PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist [141136-83-6]

(6) IUPHAR Ligand for F2RL1 Gene

(79) Novoseek inferred chemical compound relationships for F2RL1 Gene

Compound -log(P) Hits PubMed IDs
apc-366 79 1
serine 70.3 72
calcium 51.1 68
pd 98,059 50.6 5
trypsinogen 50 2
genes like me logo Genes that share compounds with F2RL1: view

Transcripts for F2RL1 Gene

mRNA/cDNA for F2RL1 Gene

(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL1 Gene

Coagulation factor II (thrombin) receptor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F2RL1

Clone Products

  • Addgene plasmids for F2RL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL1 Gene

No ASD Table

Relevant External Links for F2RL1 Gene

GeneLoc Exon Structure for
F2RL1
ECgene alternative splicing isoforms for
F2RL1

Expression for F2RL1 Gene

mRNA expression in normal human tissues for F2RL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2RL1 Gene

This gene is overexpressed in Colon - Transverse (9.4), Skin - Not Sun Exposed (Suprapubic) (6.6), and Skin - Sun Exposed (Lower leg) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for F2RL1 Gene

SOURCE GeneReport for Unigene cluster for F2RL1 Gene Hs.744181

mRNA Expression by UniProt/SwissProt for F2RL1 Gene

P55085-PAR2_HUMAN
Tissue specificity: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle
genes like me logo Genes that share expressions with F2RL1: view

In Situ Assay Products

Orthologs for F2RL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F2RL1 35
  • 99.66 (n)
  • 99.24 (a)
F2RL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia F2RL1 35
  • 85.86 (n)
  • 87.3 (a)
F2RL1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia F2RL1 35
  • 85.2 (n)
  • 83.69 (a)
F2RL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F2rl1 35
  • 82.17 (n)
  • 83.96 (a)
F2rl1 16
F2rl1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia F2RL1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia F2RL1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F2rl1 35
  • 80.39 (n)
  • 82.62 (a)
chicken
(Gallus gallus)
Aves F2RL1 35
  • 71.02 (n)
  • 73 (a)
F2RL1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.5507 35
tropical clawed frog
(Silurana tropicalis)
Amphibia f2rl1 35
  • 66.95 (n)
  • 65.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9406 35
zebrafish
(Danio rerio)
Actinopterygii f2rl1.1 36
  • 48 (a)
OneToMany
f2rl1.2 35
  • 58.69 (n)
  • 54.85 (a)
f2rl1.2 36
  • 49 (a)
OneToMany
Species with no ortholog for F2RL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL1 Gene

ENSEMBL:
Gene Tree for F2RL1 (if available)
TreeFam:
Gene Tree for F2RL1 (if available)

Paralogs for F2RL1 Gene

Paralogs for F2RL1 Gene

Selected SIMAP similar genes for F2RL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL1: view

Variants for F2RL1 Gene

Sequence variations from dbSNP and Humsavar for F2RL1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs639342 -- 76,817,044(+) TAGAT(A/G)TAATA upstream-variant-2KB
rs686868 -- 76,819,347(+) GGGCA(A/G)GTGTG intron-variant
rs1529505 -- 76,819,138(+) ATCGG(C/T)GGCGG utr-variant-5-prime
rs2115499 -- 76,822,508(+) CCACC(A/G)TGCCT intron-variant
rs2242983 -- 76,817,108(+) TAGGA(A/G)TCAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for F2RL1 Gene

Variant ID Type Subtype PubMed ID
nsv882210 CNV Gain 21882294
nsv882211 CNV Loss 21882294
esv994503 CNV Deletion 20482838

Relevant External Links for F2RL1 Gene

HapMap Linkage Disequilibrium report
F2RL1
Human Gene Mutation Database (HGMD)
F2RL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL1 Gene

Disorders for F2RL1 Gene

(3) University of Copenhagen DISEASES for F2RL1 Gene

(76) Novoseek inferred disease relationships for F2RL1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 63.6 84
airways disease 48.3 4
necrosis 43.2 45
tumors 40.6 100
asthma 35.9 15

Relevant External Links for F2RL1

Genetic Association Database (GAD)
F2RL1
Human Genome Epidemiology (HuGE) Navigator
F2RL1
genes like me logo Genes that share disorders with F2RL1: view

No data available for UniProtKB/Swiss-Prot for F2RL1 Gene

Publications for F2RL1 Gene

  1. Interactions of mast cell tryptase with thrombin receptors and PAR- 2. (PMID: 9020112) Molino M. … Brass L.F. (J. Biol. Chem. 1997) 3 4 23
  2. Interaction of mite allergens Der p3 and Der p9 with protease- activated receptor-2 expressed by lung epithelial cells. (PMID: 11441110) Sun G. … Mattoli S. (J. Immunol. 2001) 3 4 23
  3. Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. (PMID: 11447194) Lourbakos A. … Pike R.N. (Infect. Immun. 2001) 3 4 23
  4. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. (PMID: 8615752) Boehm S.K. … Bunnett N.W. (Biochem. J. 1996) 3 4 23
  5. Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. (PMID: 11714832) Miike S. … Kita H. (J. Immunol. 2001) 3 4 23

Products for F2RL1 Gene

  • Addgene plasmids for F2RL1

Sources for F2RL1 Gene

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