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F2RL1 Gene

protein-coding GIFtS: 62

GC05P076150

coagulation factor II (thrombin) receptor-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPR11)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GPR11 ^², ³, ⁵
PAR-2 ^³
PAR2 ^¹, ², ³, ⁵

Descriptions
Coagulation factor II receptor-like 1 ^³
G protein-coupled receptor-11 ^²
G-protein coupled receptor 11 ^³
Thrombin receptor-like 1 ^³
coagulation factor II (thrombin) receptor-like 1 ^²
protease-activated receptor 2 ^²
proteinase-activated receptor-2 ^²

External Ids
HGNC: 3538¹
Entrez Gene: 2150²
UniProtKB: P55085³
Ensembl: ENSG00000164251⁷

Search outside databases for aliases for F2RL1 gene

Previous GC identifers: GC05P074920 GC05P076349 GC05P076153 GC05P076198

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F2RL1:

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of

7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is

also a member of the protease-activated receptor family. It is activated by trypsin, but not by

thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new

amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains

two exons and is widely expressed in human tissues. The predicted protein sequence is 83%

identical to the mouse receptor sequence. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAR2_HUMAN, P55085

Function: Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate

phosphoinositide hydrolysis. May have a role in the regulation of vascular tone

Gene Wiki entry for F2RL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F2RL1 gene

Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13

F2RL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P076150: (about GC identifiers)

Start:	76,150,610 bp from pter
End:	76,166,896 bp from pter
Size:	16,287 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAR2_HUMAN, P55085 (See protein sequence)

Recommended Name: Proteinase-activated receptor 2 precursor

Size: 397 amino acids; 44126 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q13317 Q13346

Post-translational modifications:

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand¹

REFSEQ proteins: NP_005233.3

ENSEMBL proteins:

ENSP00000296677

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant F2RL1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PAR2)
	Human Recombinant Proteins from Abnova (F2RL1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	TAS	8615752
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	IDA	17848177

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Antibodies for F2RL1:

	Invitrogen Antibodies for F2RL1
	Millipore Mono- and Polyclonal Antibodies for the study of F2RL1
	Sigma-Aldrich Antibodies for F2RL1
	R&D Systems Antibodies for F2RL1 (PAR2)
	Antibodies from Abcam (PAR2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for F2RL1

Assays for F2RL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P55085

ProtoNet protein and cluster: P55085

2 Blocks protein families:

IPB002281 Protease activated receptor 2 precursor signature

IPB003912 Protease activated receptor precursor signature

UniProtKB/Swiss-Prot: PAR2_HUMAN, P55085

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F2RL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F2RL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005242

Applied Biosystems Silencer® siRNAs for F2RL1

Sigma-Aldrich siRNA and siRNA Panels for F2RL1

Sigma-Aldrich shRNA Panels and shRNA for F2RL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for F2RL1
		Millipore Clones for the Expression of F2RL1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005242
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005242
untagged cDNA clones in CMV expression vector (see all 2): NM_005242

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005242

UniProtKB/Swiss-Prot: PAR2_HUMAN, P55085

Function: Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate

phosphoinositide hydrolysis. May have a role in the regulation of vascular tone

Genatlas biochemistry entry for F2RL1:

coagulation factor II (thrombin) receptor proteinase-activated receptor 2,G protein coupled

receptor superfamily

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for F2rl1):

digestive/alimentary	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	nervous system	renal/urinary system
skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	8615752
GO:0004930	G-protein coupled receptor activity	TAS	7556175
GO:0005102	receptor binding	TAS	8615752
GO:0015057	thrombin receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for F2RL1

5/23 Interacting proteins for F2RL1 (ENSP00000296677³) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRSS1	ENSP00000290968³	STRING (score=.949)
PRSS2	ENSP00000312576³	STRING (score=.949)
PRSS3	ENSP00000354280³	STRING (score=.949)
CTSG	ENSP00000216336³	STRING (score=.934)
F2R	ENSP00000321326³	STRING (score=.91)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	7556175
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	8615752
GO:0030193	regulation of blood coagulation	IDA	17848177

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for F2RL1

Browse Small Molecules at Sigma-Aldrich

Compounds for F2RL1 available from Tocris Bioscience

Compound	Action	CAS number
AC 55541	Potent and selective PAR2 agonist	[916170-19-9]
SLIGKV-NH2	PAR2 receptor agonist	[190383-13-2]
SLIGRL-NH2	PAR2-activating peptide	[171436-38-7]
2-Furoyl-LIGRLO-amide	Potent and selective PAR2 agonist	[729589-58-6]

About this table

10/33 Novoseek chemical compound relationships for F2RL1 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
apc-366	73.92	2	9020112 (1)
butaprost	51.28	3	18981149 (1), 17028262 (1), 15539459 (1)
calcium	50.49	73	12630574 (3), 12595338 (2), 10408902 (2), 16195539 (2) (see all 49)
pd 98,059	49.95	5	17982475 (1), 18031579 (1), 15655297 (1), 16467309 (1) (see all 5)
sbti	49.68	1	12415569 (1)
trypsinogen	48.35	2	17699557 (1), 14583448 (1)
prostaglandin	33.42	6	16091786 (2), 16691544 (1), 11250873 (1)
inositol 1,4,5 trisphosphate	28.52	1	9238072 (1)
tyrosine	28.05	12	17675298 (2), 18245671 (1), 15166220 (1), 16533697 (1) (see all 10)
allergens	22.65	8	18305573 (3), 18626479 (2), 12370395 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F2RL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F2RL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005242

Sigma-Aldrich siRNA and siRNA Panels for F2RL1

Sigma-Aldrich shRNA Panels and shRNA for F2RL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005242

REFSEQ mRNAs for F2RL1 gene:

NM_005242.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005242

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005242
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005242
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005242

Additional cDNA sequence:

AY336105.1 BC012453.1 BC018130.1 BT009856.1 U34038.1 U67058.1

2 DOTS entries:

DT.213165 DT.100647861

5 AceView cDNA sequences:

AI921544 BE005953 AW272877 BE005956 AW578520

highest scoring ESTs for F2RL1:

U34038 U67058 AA232603 AA373375 AA480816 AI942392 AW362651 AW376169 AW578520 AW630645

Unigene Cluster for F2RL1:

Coagulation factor II (thrombin) receptor-like 1

Hs.154299 [show with all ESTs]

Unigene Representative Sequence: NM_005242

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000296677

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F2RL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F2RL1

¹ / ² / ³

7 probe-sets matching F2RL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38247_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.81	U67058	1.00	1.00	1.00	1
36344_at²^{, 3}	U95-A	1	1.00	1.00	0.42	1.09	U34038	1.00	1.00	1.00	1
36345_g_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.20	U34038	1.00	1.00	1.00	1
206429_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005242	0.60	1.00	0.82	1
213506_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE965369	0.20	1.00	0.72	1
206429_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213506_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks F2RL1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATACAAA

SOURCE GeneReport for Unigene cluster: Hs.154299
Expression variation in blood from EXPOLDB for F2RL1
UniProtKB/Swiss-Prot: PAR2_HUMAN, P55085
Tissue specificity: Widely expressed in tissues with especially high levels in pancreas, liver,
kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in
brain or skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F2RL1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F2RL1¹	--	coagulation factor II (thrombin) receptor-like 1	85.22(n) 84.13(a)	488940 XM_546057.1 XP_546057.1
chimpanzee (Pan troglodytes)	F2RL1¹	--	coagulation factor II (thrombin) receptor-like 1	99.66(n) 99.24(a)	461800 XM_001145175.1 XP_001145175.1
cow (Bos taurus)	F2RL1¹	--	coagulation factor II (thrombin) receptor-like 1	85.74(n) 86.84(a)	526525 NM_001046283.1 NP_001039748.1
rat (Rattus norvegicus)	F2rl1¹	--	coagulation factor II (thrombin) receptor-like 1	80.6(n) 82.87(a)	116677 NM_053897.2 NP_446349.1
mouse (Mus musculus)	F2rl1^{1, 5}	13 (46.99 cM)⁵	coagulation factor II (thrombin) receptor-like 1^{1, 5}	82.45(n)¹ 83.63(a)¹	14063¹ NM_007974.3¹ NP_032000.2¹ AK144986⁵ AK158462⁵ (see all 12)

About this table Species with no ortholog for F2RL1

ENSEMBL Gene Tree for F2RL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F2RL1 gene

P2RY8² GPR18² F2RL3² F2R² F2RL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/192 NCBI SNPs in F2RL1 are shown (see all 192 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 72)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1529505^1,2	A,C,F,H,O	76150719(+)	`ATCGGC/TGGCGG`	1	--	ut5¹ ese³		10	MN EU EA WA NS NA	856
	rs639342^1,2	C,F,H,O	76148625(+)	`TAGATG/ATAATA`	1	--	ng5¹		13	NS MN EU EA WA	1350
	rs2243083^1,2	C,F,H	76165059(+)	`TTGTCA/G/TCTGTC`	2	T/A T/S	mis¹ ese³		6	NS EU EA WA	494
	rs2242991^1,2	C,F,H	76150615(+)	`TGAAAC/GCTAAC`	1	--	ut5¹ ese³		13	NS EU EA WA	2652
	rs2242989^1,2	C,F,O	76150280(+)	`GTACGA/GATCGT`	1	--	ng5¹		5	NS NA	234
	rs616235^1,2	C,F,H	76164277(-)	`ATCTAT/CTGGTT`	1	S/N	mis¹		12	MN EU EA WA NA	1150
	rs2243062^1,2	C,F,H	76164997(+)	`GCTGCG/AATCTT`	1	Q/R	mis¹		14	NS NA EU EA WA	1148
	rs2243066^1,2	C,F,H	76165869(+)	`GTGAGT/ATGGGA`	1	--	ut3¹		15	NS EU EA WA NA	1316
	rs2243072^1,2	C,F,H	76150825(+)	`TCTCTC/TCTGCA`	1	S/F	mis¹ ese³ trp³		13	NS EU EA WA NA	1074
--	rs3135469^1,2	C,F	76165815(+)	`AATGAG/CGAAAC`	1	--	ut3¹ ese³		5	NS NA	230

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HapMap Linkage Disequilibrium images for F2RL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600933

10/75 Novoseek disease relationships for F2RL1 gene (see all 75 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	63.38	84	15753914 (5), 11841560 (3), 15654951 (3), 11698614 (2) (see all 61)
airways disease	46.85	4	14500256 (1), 15809358 (1), 11704532 (1), 16336275 (1)
necrosis	43.28	48	8663011 (2), 12176089 (1), 13130473 (1), 17979070 (1) (see all 41)
tumors	38.67	104	17761706 (5), 15250939 (4), 17203172 (3), 17936340 (3) (see all 67)
asthma	34.61	18	11673222 (2), 11692107 (2), 15753914 (2), 12783571 (1) (see all 10)
keratoconjunctivitis vernal	28.51	1	16303958 (1)
apert syndrome	24.18	1	16373332 (1)
inflammatory bowel diseases	22.80	3	11804840 (1), 19184329 (1)
hyperalgesia	22.11	14	15128844 (6), 16967049 (3), 15898281 (1), 18363639 (1) (see all 5)
pancreatic cancer	20.89	22	16525644 (4), 12527925 (3), 15660373 (3), 12792776 (2) (see all 7)

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Human Genome Epidemiology Navigator: F2RL1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/495 PubMed articles for F2RL1 gene (see all 495 ):

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. (PubMed id 7556175)^{2, 3, 4} Nystedt S....Sundelin J. (1995)
Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. (PubMed id 8784787)^{1, 3, 4} Kahn M.L.... Coughlin S.R. (1996)
Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. (PubMed id 8615752)^{1, 3, 4} Boehm S.K....Bunnett N.W. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular cloning of a potential proteinase activated receptor. (PubMed id 7937743)^{2, 3} Nystedt S....Sundelin J. (1994)
Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2. (PubMed id 12540381)^{1, 3} Roosterman D....Bunnett N.W. (2003)
Expression of proteinase-activated receptor-2 in the intervertebral disc. (PubMed id 19247167)^{1, 3} Iida R....Uchida A. (2009)
Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist. (PubMed id 17328048)^{1, 3} Kelso E.B....McInnes I.B. (2007)
Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers. (PubMed id 17203172)^{1, 3} Jahan I....Tamaya T. (2007)
Interactions of mast cell tryptase with thrombin receptors and PAR-2. (PubMed id 9020112)^{1, 3} Molino M....Brass L.F. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2150	HGNC: 3538	AceView: F2RL1	Ensembl:ENSG00000164251	euGenes: HUgn2150
ECgene: F2RL1	H-InvDB: F2RL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Protease-activated_receptor
SeattleSNPs	http://pga.gs.washington.edu/data/f2rl1/

Licensable Technologies for F2RL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F2RL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F2RL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F2RL1		Antibodies for F2RL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for F2RL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (F2RL1)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (PAR2)

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Tocris compounds for F2RL1

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F2RL1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for F2RL1

Summaries
for F2RL1

Genomic Location
for F2RL1

Proteins
for F2RL1

Protein Domains/
Families
for F2RL1

Gene Function
for F2RL1

Pathways & Interactions
for F2RL1

Drugs & Compounds
for F2RL1

Transcripts
for F2RL1

Expression
for F2RL1

Orthologs
for F2RL1

Paralogs
for F2RL1

SNPs/Variants
for F2RL1

Disorders & Mutations
for F2RL1

Medical News
for F2RL1

Publications
for F2RL1

Search for F2RL1

Genome Databases showing F2RL1

Other Databases showing F2RL1

Specialized Databases showing F2RL1

Licensable Technologies
for F2RL1

Services
for F2RL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F2RL1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor F2RL1

Summariesfor F2RL1

Genomic Locationfor F2RL1

Proteinsfor F2RL1

Protein Domains/Familiesfor F2RL1

Gene Functionfor F2RL1

Pathways & Interactionsfor F2RL1

Drugs & Compoundsfor F2RL1

Transcriptsfor F2RL1

Expression for F2RL1

Orthologsfor F2RL1

Paralogsfor F2RL1

SNPs/Variantsfor F2RL1

Disorders & Mutationsfor F2RL1

Medical Newsfor F2RL1

Publicationsfor F2RL1

Search for F2RL1

Genome Databases showing F2RL1

Other Databases showing F2RL1

Specialized Databases showing F2RL1

Licensable Technologiesfor F2RL1

Servicesfor F2RL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F2RL1

Summaries
for F2RL1

Genomic Location
for F2RL1

Proteins
for F2RL1

Protein Domains/
Families
for F2RL1

Gene Function
for F2RL1

Pathways & Interactions
for F2RL1

Drugs & Compounds
for F2RL1

Transcripts
for F2RL1

Expression
for F2RL1

Orthologs
for F2RL1

Paralogs
for F2RL1

SNPs/Variants
for F2RL1

Disorders & Mutations
for F2RL1

Medical News
for F2RL1

Publications
for F2RL1

Licensable Technologies
for F2RL1

Services
for F2RL1