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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

F2R Gene

protein-coding   GIFtS: 71
GCID: GC05P076047

Coagulation Factor II (Thrombin) Receptor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coagulation Factor II (Thrombin) Receptor1 2     HTR2
CF2R2 3 5     Protease-Activated Receptor 12
PAR12 3 5     Proteinase-Activated Receptor 12
PAR-12 3     Coagulation Factor II Receptor3
TR2 3     Thrombin Receptor3

External Ids:    HGNC: 35371   Entrez Gene: 21492   Ensembl: ENSG000001811047   OMIM: 1879305   UniProtKB: P251163   

Export aliases for F2R gene to outside databases

Previous GC identifers: GC05P074817 GC05P076246 GC05P076050 GC05P076095 GC05P071219


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F2R Gene:
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response.
Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.
(provided by RefSeq, Jul 2008)

GeneCards Summary for F2R Gene: 
F2R (coagulation factor II (thrombin) receptor) is a protein-coding gene. Diseases associated with F2R include thrombasthenia, and glanzmann's thrombasthenia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Complement and Coagulation Cascades. GO annotations related to this gene include G-protein alpha-subunit binding and G-protein coupled receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide
hydrolysis. May play a role in platelets activation and in vascular development

summary for F2R Gene:
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors,
activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide
ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling.
Four subtypes of receptors have so far been cloned (PAR1-4). PAR1 is the most well characterized member of
this receptor family and is activated by the endogenous serine protease thrombin. Thrombin has a primary
role in vessel wound healing and revascularization and acts via PAR1 receptors on platelets, endothelial
cells, smooth muscle cells, neutrophils, leukocytes, neurons and glial cells to facilitate a coordinated
response to vessel damage. Thrombin-mediated PAR1 activation induces platelet aggregation. Thrombin
stimulates 5-HT, ATP and thromboxane A2 release, integrin alphaIIb/beta3 activation, and P-selectin and CD40
translocation to facilitate the binding of platelets to endothelial cells. Activation of endothelial cells
is a key component in clotting and wound healing, and is mediated by PAR1 stimulation. Activation of PAR1 by
thrombin stimulates von Willebrand factor release, tissue factor expression and adhesion molecule
expression, which further promotes clotting and coagulation as well as facilitating the rapid adherence of
neutrophils, monocytes and lymphocytes to endothelial cells. Thrombin has direct promitogenic activity in
fibroblasts, vascular smooth muscle cells, endothelial cells and some myeloid cells. Thrombin-mediated PAR1
activation also induces expression of promitogenic factors and their receptors such as PDGF/PDGFR and
ET-1/ETA and ET-B. PAR1 is known to couple to several heterotrimeric G proteins and regulates multiple
kinase signaling pathways including PI 3-K, Src family tyrosine kinases, JNK, Rho kinases, JAK2 and FAK.

Gene Wiki entry for F2R (Coagulation factor II receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the F2R gene promoter:
         Sp1   AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   CREB   deltaCREB   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): F2R promoter sequence
   Search SABiosciences Chromatin IP Primers for F2R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13

F2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2R gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P076047:  view genomic region     (about GC identifiers)

Start:
76,011,868 bp from pter      End:
76,031,606 bp from pter
Size:
19,739 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116 (See protein sequence)
Recommended Name: Proteinase-activated receptor 1 precursor  
Size: 425 amino acids; 47441 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
6/10 PDB 3D structures from and Proteopedia for F2R (see all 10):
1NRN (3D)        1NRO (3D)        1NRP (3D)        1NRQ (3D)        1NRR (3D)        3BEF (3D)    
Secondary accessions: Q53XV0 Q96RF7 Q9BUN4

Explore the universe of human proteins at neXtProt for F2R: NX_P25116

Explore proteomics data for F2R at MOPED 

Post-translational modifications:

  • UniProtKB: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
  • UniProtKB: Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and
    internalization of the receptor
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25116

  • F2R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    F2R Protein Expression
    REFSEQ proteins: NP_001983.2  
    ENSEMBL proteins: 
     ENSP00000321326   ENSP00000426398  
    Reactome Protein details: P25116
    Human Recombinant Protein Products for F2R: 
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    Novus Biologicals F2R Proteins
    Novus Biologicals F2R Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005794Golgi apparatus TAS7961693
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1672265
    GO:0005901caveola IDA17848177

    F2R for ontologies           About GeneDecksing



    F2R Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    F2R: GPCR / Class A : Protease activated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAR1 
    Protease-activated receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003912 Protea_act_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000935 Thrmbn_rcpt

    Graphical View of Domain Structure for InterPro Entry P25116

    ProtoNet protein and cluster: P25116

    2 Blocks protein domains:
    IPB000935 Thrombin receptor signature
    IPB003912 Protease activated receptor precursor signature


    UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
    Domain: The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor
    peptide known as parstatin
    Similarity: Belongs to the G-protein coupled receptor 1 family


    F2R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR1_HUMAN, P25116
    Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide
    hydrolysis. May play a role in platelets activation and in vascular development

         Genatlas biochemistry entry for F2R:
    coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the common proximal
    breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor superfamily

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding ISS--
    GO:0004930G-protein coupled receptor activity TAS17848177
    GO:0005102receptor binding IPI1672265
    GO:0005515protein binding IPI17848177
    GO:0015057thrombin receptor activity IDA10692450
         
    F2R for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for F2R:
     Increased gamma-H2AX phosphory 

         15/16 MGI mutant phenotypes (inferred from 6 alleles(MGI details for F2r) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system  tumorigenesis 

    F2R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for F2R: F2rtm1Pago F2rtm1Ajc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for F2R 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for F2R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F2R 
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    hsa-miR-3685 hsa-miR-106a hsa-miR-93 hsa-miR-3662 hsa-miR-526b* hsa-miR-450b-5p hsa-miR-515-3p hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidF2R 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for F2R About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Complement and coagulation cascades
    Complement and Coagulation Cascades0.71
    Complement and coagulation cascades0.71
    3Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for F2R
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Cell adhesion Integrin inside-out signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F2R
        Glioma Invasiveness
    p70S6K Signaling
    JAK-STAT Pathway
    Thrombin Signaling
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for F2R
        Cell adhesion Integrin inside-out signaling

    4 BioSystems Pathways for F2R
        GPCRs, Other
    Regulation of Actin Cytoskeleton
    GPCRs, Class A Rhodopsin-like
    Complement and Coagulation Cascades


    5/11        Reactome Pathways for F2R (see all 11)
        GPCR downstream signaling
    Hemostasis
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR

    1 PharmGKB Pathway for F2R
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/6         Kegg Pathways  (Kegg details for F2R) (see all 6):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway
    Complement and coagulation cascades


    F2R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for F2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/169 Interacting proteins for F2R (P251161, 3 ENSP000003213264) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=2 STRING: ENSP00000308541
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    CAPN1P073843, ENSP000002792474I2D: score=1 STRING: ENSP00000279247
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GNAT1P114883, ENSP000002324614I2D: score=1 STRING: ENSP00000232461
    About this table

    Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity ISS--
    GO:0002248connective tissue replacement involved in inflammatory response wound healing IDA9639571
    GO:0003105negative regulation of glomerular filtration ISS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA10692450
    GO:0006954inflammatory response ISS--

    F2R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    F2R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for F2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist [245520-69-8]
    SLIGKV-NH2PAR2 receptor agonist[190383-13-2]
    TFLLR-NH2PAR1-activating peptide[197794-83-5]
    2-Furoyl-LIGRLO-amidePotent and selective PAR2 agonist[729589-58-6]
    TRAP-6PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist[141136-83-6]

    1 DrugBank Compound for F2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Streptokinase-- 9002-01-1targetcleavage10666203

    5 IUPHAR Ligands for F2R (PAR1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    SCH530348
    AntagonistAntagonist8.0918447380
    [3H]haTRAP
    AgonistAgonist7.829203642
    RWJ-56110
    AntagonistAntagonist6.3610535908
    TFLLR-NH2
    AgonistFull agonist5.4111877318
    atopaxar
    AntagonistAntagonist5.4119572075

    10/118 Novoseek inferred chemical compound relationships for F2R gene (see all 118)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fllrn 84.6 6 16427862 (2), 10917956 (1), 7834643 (1)
    hirudin 84.4 31 19929245 (3), 15118533 (2), 1654318 (2), 9639571 (1) (see all 21)
    sfflrnp 78.6 2 8074233 (1), 8074680 (1)
    cangrelor 77.1 2 18657683 (1), 18462654 (1), 18369175 (1), 18991794 (1)
    ppack 70.9 3 9083795 (1), 10404777 (1)
    serine 70 40 15191806 (2), 14559973 (2), 10908720 (2), 12030612 (1) (see all 32)
    prasugrel 68.4 4 18462654 (1), 18369175 (1), 18991794 (1)
    adp 64.3 40 12871418 (3), 15078882 (3), 17675219 (2), 11722114 (2) (see all 26)
    fibrinogen 58.9 38 10891092 (4), 10395938 (4), 11460501 (2), 17115723 (2) (see all 25)
    clopidogrel 58.6 6 16194864 (2), 18520610 (1), 16837456 (1), 15477442 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about F2R / PAR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for F2R gene: 
    NM_001992.3  

    Unigene Cluster for F2R:

    Coagulation factor II (thrombin) receptor
    Hs.482562  [show with all ESTs]
    Unigene Representative Sequence: NM_001992
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319211(uc003ken.4) ENST00000505600
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK297131.1 AK308169.1 AK314202.1 AY771596.1 BC002464.2 BC016059.1 BC051909.1 BT007279.1 
    M62424.1 M93111.1 S76625.1 

    12 DOTS entries:

    DT.453981  DT.100786133  DT.120839242  DT.92066564  DT.102828402  DT.120839109  DT.120839110  DT.120839127 
    DT.120839266  DT.86843855  DT.121073993  DT.87046583 

    24/117 AceView cDNA sequences (see all 117):

    BM479604 CA434342 BG678898 N43757 AI921649 BF438574 CA424375 BM994328 
    AI520885 BC016059 BC051909 BC002464 AL045309 CA438126 BT007279 BM756571 
    AU123806 AA450199 BU616929 BP347223 AU142813 BQ001546 CA437630 N35000 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for F2R    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for F2R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    F2R expression in normal human tissues (normalized intensities)      F2R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTCACAA
    F2R Expression
    About this image


    F2R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See F2R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for F2R

    SOURCE GeneReport for Unigene cluster: Hs.482562

    UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
    Tissue specificity: Platelets and vascular endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including F2R: 
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              Apoptosis 384HT in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for F2R gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F2r1 , 5 coagulation factor II (thrombin) receptor1, 5 79.56(n)1
    79.25(a)1
      13 (50.21 cM)5
    140621  NM_010169.31  NP_034299.21 
     956017895 
    chicken
    (Gallus gallus)
    Aves F2R1 coagulation factor II (thrombin) receptor 63.16(n)
    61.12(a)
      427212  XM_424799.3  XP_424799.2 
    lizard
    (Anolis carolinensis)
    Reptilia F2R6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    2(14202163-14220165)
    African clawed frog
    (Xenopus laevis)
    Amphibia f2r-A-prov2 coagulation factor II (thrombin) receptor 71.67(n)    U09632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f2r1 coagulation factor II (thrombin) receptor 56.1(n)
    47.54(a)
      558477  NM_001114846.1  NP_001108318.1 


    ENSEMBL Gene Tree for F2R (if available)
    TreeFam Gene Tree for F2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for F2R gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  F2RL22  
    GPR1322  FFAR12  GPR422  F2RL32  
    8 SIMAP similar genes for F2R using alignment to 2 protein entries:     PAR1_HUMAN (see all proteins):
    HTR    F2RL1    LPAR6    P2RY5    P2RY8    F2RL2
    F2RL3    GPR17

    F2R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in F2R are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114357771,2
    C--76015413(+) AAAAA-/AGAGGT 1 -- int1 trp30--------
    rs38368271,2
    C--76018342(+) TACTT-/TCCTGC 1 -- int10--------
    rs114590241,2
    C--76018775(+) AAAAAA/-GAATT 1 -- int1 trp32Minor allele frequency- -:0.25NA 4
    rs22277791,2
    C,F--76021447(+) CTACAT/-TTTTT 1 -- int1 trp37Minor allele frequency- -:0.18NS NA CSA 170
    rs777682231,2
    --76021454(+) TTTTTC/TTTTTC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs22277821,2
    C,F--76022213(+) tagccG/Aggcgc 1 -- int15Minor allele frequency- A:0.02NS NA WA 146
    rs22277901,2
    C,F--76025244(+) tcagaC/Tgtatg 1 -- int16Minor allele frequency- T:0.14NS NA CSA WA 256
    rs789655721,2
    F--76303550(+) GAACTA/GTGTAA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs22277431,2
    C,F,H--76303551(+) AACTAT/CGTAAT 1 -- us2k113Minor allele frequency- C:0.06NS EA NA WA 720
    rs1876940451,2
    --76303569(+) GTTCAC/TATTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for F2R (76011868 - 76031606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for F2R:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730323CNV Deletion23290073
    esv2730324CNV Deletion23290073
    dgv6186n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): F2R
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 187930    OMIM disorders: --

    20/107 diseases for F2R (see all 107):    About MalaCards
    thrombasthenia    glanzmann's thrombasthenia    bernard-soulier syndrome    peroxisome biogenesis disorders
    crescentic glomerulonephritis    blastoma    thromboembolism    thrombosis
    prader-willi syndrome    hepatitis a    thrombophilia    venous thromboembolism
    gaucher's disease    irritable bowel syndrome    glomerulonephritis    pituitary tumors
    antiphospholipid syndrome    thrombocytopenia    squamous cell carcinoma of the head and neck    fibrous histiocytoma

    2 diseases from the University of Copenhagen DISEASES database for F2R:
    Vascular disease     Heart disease

    F2R for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for F2R gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 57.7 32 20445954 (3), 10669659 (2), 14529396 (2), 11408522 (2) (see all 19)
    inflammation 51.8 66 15545995 (3), 14597986 (3), 18570113 (3), 16116312 (2) (see all 39)
    astrocytoma 42.2 9 16231009 (2), 10664248 (2), 9359863 (1), 8930892 (1) (see all 5)
    arterial thrombosis 41.6 10 7796507 (3), 20144050 (1), 19699853 (1), 9432025 (1) (see all 5)
    5q- syndrome 41.1 1 8602997 (1)
    restenosis 35.9 22 9186620 (2), 14529396 (2), 18000795 (2), 8328214 (1) (see all 14)
    necrosis 34.7 58 9435232 (1), 12975637 (1), 15289504 (1), 15897419 (1) (see all 49)
    tumors 33.7 151 11278329 (4), 16608645 (4), 11395381 (3), 16707447 (2) (see all 99)
    atherosclerosis 32.3 15 9186620 (2), 18000795 (2), 7863981 (1), 15063481 (1) (see all 11)
    metastasis 32.1 67 19538737 (6), 16608645 (3), 17706138 (3), 19170048 (3) (see all 30)

    Genetic Association Database (GAD): F2R
    Human Genome Epidemiology (HuGE) Navigator: F2R (56 documents)

    Export disorders for F2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for F2R gene, integrated from 9 sources (see all 1084):
    (articles sorted by number of sources associating them with F2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 2, 9 Kahn M.L....Coughlin S.R. (1999)
    2. Retrospective analysis of coagulation factor II receptor (F2R) sequence variation and coronary heart disease in hypertensive patients. (PubMed id 17347481)1, 4, 9 Gigante B....Trimarco B. (2007)
    3. The protease-activated receptor 1 possesses a function al and cleavable signal peptide which is necessary for receptor expression. (PubMed id 22659187)1, 2 Zampatis D.E....Schulein R. (2012)
    4. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Platelet gene polymorphisms and risk of bleeding in p atients undergoing elective coronary angiography: a genetic substudy of the PRA GUE-8 trial. (PubMed id 20691446)1, 4 Motovska Z....Widimsky P. (2010)
    8. The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in me n. (PubMed id 20585578)1, 4 Gigante B....de Faire U. (2010)
    9. Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels. (PubMed id 19404549)1, 4 Gigante B....de Faire U. (2009)
    10. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1, 4 Silander K....Peltonen L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2149 HGNC: 3537 AceView: F2R Ensembl:ENSG00000181104 euGenes: HUgn2149
    ECgene: F2R Kegg: 2149 H-InvDB: F2R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for F2R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for F2R Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/f2r/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for F2R gene:
    Search GeneIP for patents involving F2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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