Free for academic non-profit institutions. Other users need a Commercial license

Aliases for F2R Gene

Aliases for F2R Gene

  • Coagulation Factor II Thrombin Receptor 2 3
  • Coagulation Factor II (Thrombin) Receptor 2 3 5
  • Protease Activated Receptor 1 2 3
  • PAR-1 3 4
  • CF2R 3 4
  • PAR1 3 4
  • TR 3 4
  • Coagulation Factor II Receptor 4
  • Protease-Activated Receptor 1 3
  • Thrombin Receptor 4
  • HTR 3

External Ids for F2R Gene

Previous GeneCards Identifiers for F2R Gene

  • GC05P074817
  • GC05P076246
  • GC05P076050
  • GC05P076095
  • GC05P076047
  • GC05P071219

Summaries for F2R Gene

Entrez Gene Summary for F2R Gene

  • Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for F2R Gene

F2R (Coagulation Factor II Thrombin Receptor) is a Protein Coding gene. Diseases associated with F2R include dyskeratosis congenita, autosomal dominant 1 and aplastic anemia. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein alpha-subunit binding. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for F2R Gene

  • High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Tocris Summary for F2R Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2R Gene

Genomics for F2R Gene

Regulatory Elements for F2R Gene

Promoters for F2R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around F2R on UCSC Golden Path with GeneCards custom track

Genomic Location for F2R Gene

Chromosome:
5
Start:
76,716,043 bp from pter
End:
76,735,781 bp from pter
Size:
19,739 bases
Orientation:
Plus strand

Genomic View for F2R Gene

Genes around F2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2R Gene

Proteins for F2R Gene

  • Protein details for F2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25116-PAR1_HUMAN
    Recommended name:
    Proteinase-activated receptor 1
    Protein Accession:
    P25116
    Secondary Accessions:
    • Q53XV0
    • Q96RF7
    • Q9BUN4

    Protein attributes for F2R Gene

    Size:
    425 amino acids
    Molecular mass:
    47441 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2R Gene

neXtProt entry for F2R Gene

Proteomics data for F2R Gene at MOPED

Post-translational modifications for F2R Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
  • Glycosylation at Asn 35, Asn 62, Asn 75, Asn 250, and Asn 259
  • Modification sites at PhosphoSitePlus

Other Protein References for F2R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for F2R Gene

Domains & Families for F2R Gene

Gene Families for F2R Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for F2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25116

UniProtKB/Swiss-Prot:

PAR1_HUMAN :
  • The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2R: view

Function for F2R Gene

Molecular function for F2R Gene

GENATLAS Biochemistry:
coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the common proximal breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
genes like me logo Genes that share phenotypes with F2R: view

Animal Models for F2R Gene

MGI Knock Outs for F2R:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2R Gene

Localization for F2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for F2R Gene COMPARTMENTS Subcellular localization image for F2R gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 4
golgi apparatus 4
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005901 caveola IDA 17848177
GO:0009986 cell surface IDA 24732013
GO:0016021 integral component of membrane IEA --
GO:0031094 platelet dense tubular network IDA 9038223
genes like me logo Genes that share ontologies with F2R: view

Pathways & Interactions for F2R Gene

genes like me logo Genes that share pathways with F2R: view

SIGNOR curated interactions for F2R Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity ISS --
GO:0002248 connective tissue replacement involved in inflammatory response wound healing IDA 9639571
GO:0003105 negative regulation of glomerular filtration ISS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 10692450
GO:0006954 inflammatory response IEA,ISS --
genes like me logo Genes that share ontologies with F2R: view

Drugs & Compounds for F2R Gene

(70) Drugs for F2R Gene - From: Novoseek, DrugBank, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vorapaxar Approved Pharma Target, antagonist 13
Streptokinase Approved Pharma Target, cleavage 13
Argatroban Approved, Investigational Pharma Thrombin mediated fibrinogen cleavage inhibitor 18
SCH-530348 Investigational Pharma Target 0
SR-123781A Investigational Pharma Target 0

(67) Additional Compounds for F2R Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>3</sup>H]haTRAP
Agonist
atopaxar
Antagonist
RWJ-56110
Antagonist
SCH530348
Antagonist
TFLLR-NH<sub>2</sub>
Full agonist, Agonist
genes like me logo Genes that share compounds with F2R: view

Transcripts for F2R Gene

mRNA/cDNA for F2R Gene

Unigene Clusters for F2R Gene

Coagulation factor II (thrombin) receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for F2R Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for F2R Gene

GeneLoc Exon Structure for
F2R
ECgene alternative splicing isoforms for
F2R

Expression for F2R Gene

mRNA expression in normal human tissues for F2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2R Gene

This gene is overexpressed in Minor Salivary Gland (x4.6) and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for F2R Gene

This gene is overexpressed in Testis (31.6), Breast (23.2), and Platelet (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for F2R Gene



SOURCE GeneReport for Unigene cluster for F2R Gene Hs.482562

mRNA Expression by UniProt/SwissProt for F2R Gene

P25116-PAR1_HUMAN
Tissue specificity: Platelets and vascular endothelial cells.
genes like me logo Genes that share expression patterns with F2R: view

Protein tissue co-expression partners for F2R Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for F2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F2R 35
  • 99.53 (n)
  • 99.29 (a)
F2R 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia F2R 36
  • 79 (a)
OneToOne
F2R 35
  • 80.55 (n)
  • 79.29 (a)
dog
(Canis familiaris)
Mammalia F2R 35
  • 86.41 (n)
  • 88.61 (a)
F2R 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia F2r 36
  • 78 (a)
OneToOne
F2r 16
F2r 35
  • 79.87 (n)
  • 79.48 (a)
oppossum
(Monodelphis domestica)
Mammalia F2R 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia F2r 35
  • 79.01 (n)
  • 79.72 (a)
chicken
(Gallus gallus)
Aves F2R 36
  • 58 (a)
OneToOne
F2R 35
  • 63.18 (n)
  • 61.19 (a)
lizard
(Anolis carolinensis)
Reptilia F2R 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia f2r-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia f2r 35
  • 59.49 (n)
  • 53.79 (a)
zebrafish
(Danio rerio)
Actinopterygii f2r 36
  • 43 (a)
OneToOne
f2r 35
  • 56.88 (n)
  • 48.1 (a)
Species with no ortholog for F2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2R Gene

ENSEMBL:
Gene Tree for F2R (if available)
TreeFam:
Gene Tree for F2R (if available)

Paralogs for F2R Gene

(7) SIMAP similar genes for F2R Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2R: view

Variants for F2R Gene

Sequence variations from dbSNP and Humsavar for F2R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs5893 - 76,732,721(+) CCGGC(A/G)GTGAT reference, missense
rs2230849 - 76,732,784(-) ACATG(A/T)ACGCC reference, missense
rs2227832 - 76,732,994(+) ATGAT(G/T)TGCTC reference, missense
rs2227799 - 76,733,460(+) CTGCT(A/C)TAGTA reference, missense
rs1055103 - 76,733,027(+) ACTAT(C/G)CCTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for F2R Gene

Variant ID Type Subtype PubMed ID
dgv6186n71 CNV Gain 21882294
esv2730323 CNV Deletion 23290073
esv2730324 CNV Deletion 23290073

Variation tolerance for F2R Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for F2R Gene

HapMap Linkage Disequilibrium report
F2R
Human Gene Mutation Database (HGMD)
F2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2R Gene

Disorders for F2R Gene

MalaCards: The human disease database

(8) MalaCards diseases for F2R Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search F2R in MalaCards View complete list of genes associated with diseases

Relevant External Links for F2R

Genetic Association Database (GAD)
F2R
Human Genome Epidemiology (HuGE) Navigator
F2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
F2R
genes like me logo Genes that share disorders with F2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F2R Gene

Publications for F2R Gene

  1. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn M.L. … Coughlin S.R. (J. Clin. Invest. 1999) 3 4 23 67
  2. Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. (PMID: 19795418) Wang W. … Takayama T.K. (Int. J. Cancer 2010) 3 23
  3. Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells. (PMID: 20056842) Gratio V. … Darmoul D. (Am. J. Pathol. 2010) 3 23
  4. N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. (PMID: 20368337) Soto A.G. … Trejo J. (J. Biol. Chem. 2010) 3 23
  5. Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype. (PMID: 20084489) Silini A. … Giavazzi R. (Clin. Exp. Metastasis 2010) 3 23

Products for F2R Gene

Sources for F2R Gene

Back to Top

Content