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Aliases for F2R Gene

Aliases for F2R Gene

  • Coagulation Factor II (Thrombin) Receptor 2 3
  • PAR1 3 4 6
  • CF2R 3 4 6
  • PAR-1 3 4
  • TR 3 4
  • Proteinase-Activated Receptor 1 3
  • Coagulation Factor II Receptor 4
  • Protease-Activated Receptor 1 3
  • Thrombin Receptor 4
  • HTR 3

External Ids for F2R Gene

Previous GeneCards Identifiers for F2R Gene

  • GC05P074817
  • GC05P076246
  • GC05P076050
  • GC05P076095
  • GC05P076047
  • GC05P071219

Summaries for F2R Gene

Entrez Gene Summary for F2R Gene

  • Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]

GeneCards Summary for F2R Gene

F2R (Coagulation Factor II (Thrombin) Receptor) is a Protein Coding gene. Diseases associated with F2R include melanoma metastasis. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein alpha-subunit binding. An important paralog of this gene is GPR132.

UniProtKB/Swiss-Prot for F2R Gene

  • High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Tocris Summary for F2R Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling. Four subtypes of receptors have so far been cloned (PAR1-4). PAR1 is the most well characterized member of this receptor family and is activated by the endogenous serine protease thrombin. Thrombin has a primary role in vessel wound healing and revascularization and acts via PAR1 receptors on platelets, endothelial cells, smooth muscle cells, neutrophils, leukocytes, neurons and glial cells to facilitate a coordinated response to vessel damage. Thrombin-mediated PAR1 activation induces platelet aggregation. Thrombin stimulates 5-HT, ATP and thromboxane A2 release, integrin alphaIIb/beta3 activation, and P-selectin and CD40 translocation to facilitate the binding of platelets to endothelial cells. Activation of endothelial cells is a key component in clotting and wound healing, and is mediated by PAR1 stimulation. Activation of PAR1 by thrombin stimulates von Willebrand factor release, tissue factor expression and adhesion molecule expression, which further promotes clotting and coagulation as well as facilitating the rapid adherence of neutrophils, monocytes and lymphocytes to endothelial cells. Thrombin has direct promitogenic activity in fibroblasts, vascular smooth muscle cells, endothelial cells and some myeloid cells. Thrombin-mediated PAR1 activation also induces expression of promitogenic factors and their receptors such as PDGF/PDGFR and ET-1/ETA and ET-B. PAR1 is known to couple to several heterotrimeric G proteins and regulates multiple kinase signaling pathways including PI 3-K, Src family tyrosine kinases, JNK, Rho kinases, JAK2 and FAK.

Gene Wiki entry for F2R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2R Gene

Genomics for F2R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for F2R Gene

76,716,043 bp from pter
76,735,781 bp from pter
19,739 bases
Plus strand

Genomic View for F2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2R Gene

Proteins for F2R Gene

  • Protein details for F2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteinase-activated receptor 1
    Protein Accession:
    Secondary Accessions:
    • Q53XV0
    • Q96RF7
    • Q9BUN4

    Protein attributes for F2R Gene

    425 amino acids
    Molecular mass:
    47441 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for F2R Gene

neXtProt entry for F2R Gene

Proteomics data for F2R Gene at MOPED

Post-translational modifications for F2R Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
  • Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
  • Glycosylation at Asn35, Asn62, Asn75, Asn250, and Asn259
  • Modification sites at PhosphoSitePlus

Other Protein References for F2R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for F2R Gene

Domains for F2R Gene

Gene Families for F2R Gene

  • F2R :GPCR / Class A : Protease activated receptors

Suggested Antigen Peptide Sequences for F2R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P25116
  • The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2R: view

Function for F2R Gene

Molecular function for F2R Gene

GENATLAS Biochemistry:
coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the common proximal breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Gene Ontology (GO) - Molecular Function for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding ISS --
GO:0004930 G-protein coupled receptor activity TAS 17848177
GO:0005102 receptor binding IPI 1672265
GO:0005515 protein binding IPI 17848177
GO:0015057 thrombin receptor activity IDA 10692450
genes like me logo Genes that share ontologies with F2R: view
genes like me logo Genes that share phenotypes with F2R: view

Animal Models for F2R Gene

MGI Knock Outs for F2R:

Animal Model Products

miRNA for F2R Gene

miRTarBase miRNAs that target F2R

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F2R

Clone Products

  • Addgene plasmids for F2R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for F2R Gene

Localization for F2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for F2R Gene COMPARTMENTS Subcellular localization image for F2R gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005769 early endosome IDA 22547407
GO:0005770 late endosome IDA 24732013
GO:0005794 Golgi apparatus TAS 7961693
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F2R: view

Pathways for F2R Gene

genes like me logo Genes that share pathways with F2R: view

PCR Array Products

Gene Ontology (GO) - Biological Process for F2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity ISS --
GO:0002248 connective tissue replacement involved in inflammatory response wound healing IDA 9639571
GO:0003105 negative regulation of glomerular filtration ISS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 10692450
GO:0006954 inflammatory response ISS --
genes like me logo Genes that share ontologies with F2R: view

Compounds for F2R Gene

(5) Tocris Compounds for F2R Gene

Compound Action Cas Number
SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist [1216720-69-2]
SLIGKV-NH2 PAR2 receptor agonist [190383-13-2]
SLIGRL-NH2 PAR2-activating peptide [171436-38-7]
tcY-NH2 Selective PAR4 antagonist [327177-34-4]
TRAP-6 PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist [141136-83-6]

(4) ApexBio Compounds for F2R Gene

Compound Action Cas Number
Argatroban Thrombin mediated fibrinogen cleavage inhibitor [74863-84-6]
Axitinib (AG 013736) VEGFR1/ c-Kit inhibitor [319460-85-0]
ML161 PAR1 inhibitor [423735-93-7]
Thrombin Receptor Activator for Peptide 5 (TRAP-5) [141685-53-2]

(1) Drugbank Compounds for F2R Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
9002-01-1 target cleavage

(5) IUPHAR Ligand for F2R Gene

Ligand Type Action Affinity Pubmed IDs
SCH530348 Antagonist Antagonist 8.09
[3H]haTRAP Agonist Agonist 7.82
RWJ-56110 Antagonist Antagonist 6.36
TFLLR-NH2 Agonist Full agonist 5.41
atopaxar Antagonist Antagonist

(118) Novoseek inferred chemical compound relationships for F2R Gene

Compound -log(P) Hits PubMed IDs
fllrn 84.6 4
hirudin 84.4 25
sfflrnp 78.6 2
cangrelor 77.1 4
ppack 70.9 2
genes like me logo Genes that share compounds with F2R: view

Transcripts for F2R Gene

mRNA/cDNA for F2R Gene

(11) Additional mRNA sequences :
(117) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2R Gene

Coagulation factor II (thrombin) receptor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F2R

Clone Products

  • Addgene plasmids for F2R

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F2R Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for F2R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F2R Gene

mRNA expression in normal human tissues for F2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2R Gene

This gene is overexpressed in Minor Salivary Gland (4.6) and Artery - Aorta (4.4).

Protein differential expression in normal tissues for F2R Gene

This gene is overexpressed in Testis (31.6), Breast (23.2), and Platelet (14.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for F2R Gene

SOURCE GeneReport for Unigene cluster for F2R Gene Hs.482562

mRNA Expression by UniProt/SwissProt for F2R Gene

Tissue specificity: Platelets and vascular endothelial cells
genes like me logo Genes that share expressions with F2R: view

In Situ Assay Products

Orthologs for F2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia F2R 35
  • 80.55 (n)
  • 79.29 (a)
F2R 36
  • 79 (a)
(Canis familiaris)
Mammalia F2R 35
  • 86.41 (n)
  • 88.61 (a)
F2R 36
  • 83 (a)
(Mus musculus)
Mammalia F2r 35
  • 79.87 (n)
  • 79.48 (a)
F2r 16
F2r 36
  • 78 (a)
(Pan troglodytes)
Mammalia F2R 35
  • 99.53 (n)
  • 99.29 (a)
F2R 36
  • 99 (a)
(Rattus norvegicus)
Mammalia F2r 35
  • 79.01 (n)
  • 79.72 (a)
(Monodelphis domestica)
Mammalia F2R 36
  • 70 (a)
(Gallus gallus)
Aves F2R 35
  • 63.18 (n)
  • 61.19 (a)
F2R 36
  • 58 (a)
(Anolis carolinensis)
Reptilia F2R 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia f2r 35
  • 59.49 (n)
  • 53.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia f2r-A-prov 35
(Danio rerio)
Actinopterygii f2r 35
  • 56.88 (n)
  • 48.1 (a)
f2r 36
  • 43 (a)
Species with no ortholog for F2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2R Gene

Gene Tree for F2R (if available)
Gene Tree for F2R (if available)

Paralogs for F2R Gene

Selected SIMAP similar genes for F2R Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2R: view

Variants for F2R Gene

Sequence variations from dbSNP and Humsavar for F2R Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs5893 - 76,732,721(+) CCGGC(A/G)GTGAT reference, missense
rs5894 -- 76,732,741(+) GGGTC(G/T)GAATT synonymous-codon, reference
rs5895 -- 76,732,610(+) TCATC(C/T)TGAAA reference, synonymous-codon
rs27134 -- 76,715,391(+) GAAGA(A/G)CTCCG upstream-variant-2KB
rs27135 -- 76,717,018(+) ACATG(A/G)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for F2R Gene

Variant ID Type Subtype PubMed ID
dgv6186n71 CNV Gain 21882294
esv2730323 CNV Deletion 23290073
esv2730324 CNV Deletion 23290073

Relevant External Links for F2R Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2R Gene

Disorders for F2R Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for F2R Gene in MalaCards »

(1) Diseases for F2R Gene including...

(2) University of Copenhagen DISEASES for F2R Gene

(94) Novoseek inferred disease relationships for F2R Gene

Disease -log(P) Hits PubMed IDs
thrombosis 57.7 25
inflammation 51.8 46
astrocytoma 42.2 7
arterial thrombosis 41.6 7
5q- syndrome 41.1 1

Relevant External Links for F2R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with F2R: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for F2R Gene

Publications for F2R Gene

  1. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn M.L. … Coughlin S.R. (J. Clin. Invest. 1999) 3 4 23
  2. Retrospective analysis of coagulation factor II receptor (F2R) sequence variation and coronary heart disease in hypertensive patients. (PMID: 17347481) Gigante B. … Trimarco B. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 23 48
  3. The angiopoietin pathway is modulated by PAR-1 activation on human endothelial progenitor cells. (PMID: 16803467) Smadja D.M. … Gaussem P. (J. Thromb. Haemost. 2006) 3 23
  4. Overexpression of protease-activated receptors-1,-2, and-4 (PAR-1, -2, and -4) in prostate cancer. (PMID: 17373694) Black P.C. … Takayama T.K. (Prostate 2007) 3 23
  5. Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. (PMID: 17376866) McLaughlin J.N. … Malik A.B. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23

Products for F2R Gene

  • Addgene plasmids for F2R

Sources for F2R Gene

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