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F2R Gene

protein-coding GIFtS: 68

GC05P076047

coagulation factor II (thrombin) receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CF2R ^¹, ², ³, ⁵
HTR ^²
PAR-1 ^³
PAR1 ^¹, ², ³, ⁵
TR ^¹, ², ³

Descriptions
Coagulation factor II receptor ^², ³
Thrombin receptor ^², ³
coagulation factor II (thrombin) receptor ^²
protease-activated receptor 1 ^²

External Ids
HGNC: 3537¹
Entrez Gene: 2149²
UniProtKB: P25116³
Ensembl: ENSG00000181104⁷

Search outside databases for aliases for F2R gene

Previous GC identifers: GC05P074817 GC05P076246 GC05P076050 GC05P076095

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for F2R:

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of

thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a

G-protein coupled receptor family member. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate

phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development

Gene Wiki entry for F2R (Coagulation_factor_II_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F2R gene

Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13

F2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P076047: (about GC identifiers)

Start:	76,047,542 bp from pter
End:	76,067,054 bp from pter
Size:	19,513 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116 (See protein sequence)

Recommended Name: Proteinase-activated receptor 1 precursor

Size: 425 amino acids; 47441 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1NRN (3D)

1NRO (3D)

1NRP (3D)

1NRQ (3D)

1NRR (3D)

3BEF (3D)

Secondary accessions: Q96RF7 Q9BUN4

Post-translational modifications:

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand¹

Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of

the receptor¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001983.2

ENSEMBL proteins:

ENSP00000321326 ENSP00000379534

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN for F2R
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Thrombin Receptor)
	Human Recombinant Proteins from Abnova (F2R)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	TAS	7961693
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1672265
GO:0005901	caveola	IDA	17848177
GO:0031094	platelet dense tubular network	IDA	9038223

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Antibodies for F2R:

	Invitrogen Antibodies for F2R
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for F2R
	R&D Systems Antibodies for F2R (PAR1)
	Antibodies from Abcam (Thrombin Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F2R)
	Novus Biologicals Antibodies for F2R

Assays for F2R:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P25116

ProtoNet protein and cluster: P25116

2 Blocks protein families:

IPB000935 Thrombin receptor signature

IPB003912 Protease activated receptor precursor signature

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F2R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F2R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001992

Applied Biosystems Silencer® siRNAs for F2R

Sigma-Aldrich siRNA and siRNA Panels for F2R

Sigma-Aldrich shRNA Panels and shRNA for F2R

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for F2R
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001992
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001992
untagged cDNA clones in CMV expression vector (see all 2): BC016059

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001992

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate

phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development

Genatlas biochemistry entry for F2R:

coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the

common proximal breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor

superfamily

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for F2r):

	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system
nervous system	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0005102	receptor binding	IPI	1672265
GO:0015057	thrombin receptor activity	TAS	9038223

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for F2R (Your Favorite Gene powered by Ingenuity)

Actin Cytoskeleton Signaling
Thrombin Signaling
Clathrin-mediated Endocytosis
Coagulation System

GeneDecks F2R for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for F2R

5/71 Interacting proteins for F2R (ENSP00000321326³) via UniProtKB, MINT, and/or STRING (see all 71 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNA13	ENSP00000239138³	STRING (score=.972)
CTSG	ENSP00000216336³	STRING (score=.955)
PROCR	ENSP00000216968³	STRING (score=.952)
PROC	ENSP00000234071³	STRING (score=.941)
PRSS1	ENSP00000290968³	STRING (score=.941)

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002248	connective tissue replacement during inflammatory response	IDA	9639571
GO:0006919	activation of caspase activity	IDA	10692450
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007260	tyrosine phosphorylation of STAT protein	IDA	10692450

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for F2R

Browse Small Molecules at Sigma-Aldrich

Compounds for F2R available from Tocris Bioscience

Compound	Action	CAS number
SCH 79797 dihydrochloride	Potent, selective non-peptide PAR1 antagonist	[245520-69-8]
TFLLR-NH2	PAR1-activating peptide	[197794-83-5]
TRAP-6	PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist	[141136-83-6]

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10/46 Novoseek chemical compound relationships for F2R gene (see all 46 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fllrn	85.14	6	16427862 (2), 10917956 (1), 7834643 (1)
sfflrnp	79.33	2	8074233 (1), 8074680 (1)
cangrelor	75.94	2	18657683 (1), 18462654 (1), 18369175 (1), 18991794 (1)
prasugrel	66.86	4	18462654 (1), 18369175 (1), 18991794 (1)
adp	61.57	38	12871418 (3), 15078882 (3), 17675219 (2), 11722114 (2) (see all 24)
phosphoinositide	59.66	22	10224146 (2), 1328213 (1), 18511035 (1), 1328861 (1) (see all 14)
fibrinogen	58.26	37	10891092 (4), 10395938 (4), 11460501 (2), 17115723 (2) (see all 24)
calcium	57.85	140	16939417 (6), 18788611 (3), 16800746 (3), 7516333 (2) (see all 90)
apotransferrin	47.23	4	14769051 (3)
tyrosine	46.96	47	16581796 (2), 7917785 (2), 15023990 (2), 15383630 (2) (see all 31)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F2R)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F2R)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001992

Sigma-Aldrich siRNA and siRNA Panels for F2R

Sigma-Aldrich shRNA Panels and shRNA for F2R

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001992

REFSEQ mRNAs for F2R gene:

NM_001992.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001992

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001992
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001992
                                 untagged cDNA clones in CMV expression vector (see all 2): BC016059

Additional cDNA sequence:

AK297131.1 AK308169.1 AK314202.1 AY771596.1 BC002464.2 BC051909.1 BT007279.1 M62424.1

M93111.1 S76625.1

11 DOTS entries:

DT.453981 DT.100786133 DT.120839242 DT.102828402 DT.120839109 DT.120839110 DT.120839127 DT.120839266

DT.121073993 DT.86843855 DT.87046583

24/117 AceView cDNA sequences (see all 117 ):

BG678898 N43757 AU142813 BQ001546 CA437630 CA424375 BM479604 BC051909

BU616929 BM994328 BP347223 CA434342 CA438126 AA450199 AI921649 BM756571

AU123806 BF438574 BT007279 AL045309 AI520885 BC016059 BC002464 BE747275

highest scoring ESTs for F2R:

M62424 AA090540 AA193590 AA193631 AA301704 AA304353 AA304477 AA307567 AA346770 AA450199

Unigene Cluster for F2R:

Coagulation factor II (thrombin) receptor

Hs.482562 [show with all ESTs]

Unigene Representative Sequence: NM_001992

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for F2R

ExUns:	1	^	2	^	3a	·	3b
SP1:
SP2:			-

About this scheme

ECgene alternative splicing isoforms for F2R

2 Ensembl transcripts including schematic representations:

ENST00000319211 ENST00000396233

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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F2R expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F2R

¹ / ² / ³

4 probe-sets matching F2R gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41700_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M62424	1.00	1.00	1.00	1
203989_x_at²^{, 3}	U133-A	5	1.00	0.89	--	--	NM_001992	0.60	1.00	0.82	1
1569642_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203989_x_at²	U133Plus2	5	1.00	0.89	--	--	--	--	--	--	--

GeneDecks F2R for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.482562
Expression variation in blood from EXPOLDB for F2R
UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
Tissue specificity: Platelets and vascular endothelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F2R gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F2R¹	--	coagulation factor II (thrombin) receptor	85.1(n) 87.16(a)	488942 XM_546059.2 XP_546059.2
chimpanzee (Pan troglodytes)	F2R¹	--	coagulation factor II (thrombin) receptor	99.16(n) 98.74(a)	471510 XM_526888.2 XP_526888.2
cow (Bos taurus)	F2R¹	--	coagulation factor II (thrombin) receptor	80.39(n) 79.06(a)	526585 XM_604958.3 XP_604958.3
rat (Rattus norvegicus)	F2r¹	--	coagulation factor II (thrombin) receptor	78.85(n) 79.25(a)	25439 NM_012950.2 NP_037082.2
mouse (Mus musculus)	F2r^{1, 5}	13 (47.00 cM)⁵	coagulation factor II (thrombin) receptor^{1, 5}	79.32(n)¹ 78.77(a)¹	14062¹ NM_010169.3¹ NP_034299.2¹ AA444959⁵ AI482343⁵ (see all 20)

About this table Species with no ortholog for F2R

ENSEMBL Gene Tree for F2R

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F2R gene

P2RY8² GPR18² F2RL1² F2RL3² F2RL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/175 NCBI SNPs in F2R are shown (see all 175 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 124)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1801719^1,2	A,C,F,H	76066552(+)	`TGACAT/CTGAAA`	1	--	ut3¹		11	NS NA EU EA WA	748
	rs2227744^1,2	A,C,F,H	76046105(+)	`CTTCTG/ATGTAC`	1	--	ng5¹		16	NS EU EA WA	1590
	rs32934^1,2	C,F,H	76046462(+)	`TCCTCC/TTGCCC`	1	--	ng5¹		10	NA EA MN EU WA NS	948
	rs2227799^1,2	C,F,H	76065041(+)	`CTGCTC/ATAGTA`	1	Y/S	mis¹		7	NS EU EA WA	546
	rs2227802^1,2	C,F,H	76066480(+)	`TTGCTC/TAAATC`	1	--	ut3¹		7	NS EU EA WA	560
	rs2227800^1,2	C,F,H	76065128(+)	`AAAAGT/CGAATA`	1	--	ut3¹ ese³		13	NS EU EA WA	1226
	rs2227801^1,2	C,F,H	76066450(+)	`TATTTA/CTTTAC`	1	--	ut3¹		16	NS EU EA WA NA	1368
	rs2227743^1,2	C,F,H	76045987(+)	`AACTAT/CGTAAT`	1	--	ng5¹		11	NS EU EA WA	602
	rs2227803^1,2	C,F,H	76066610(+)	`ACTTTA/GAAAGC`	1	--	ut3¹ ese³		7	NS EU EA WA	558
	rs27134^1,2	A,C,F	76046972(+)	`GAAGAG/ACTCCG`	1	--	ng5¹ trp³		2	NS	94

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HapMap Linkage Disequilibrium images for F2R (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 187930

10/94 Novoseek disease relationships for F2R gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombosis	54.17	24	10669659 (2), 14529396 (2), 11408522 (2), 12538843 (2) (see all 14)
inflammation	50.17	60	15545995 (3), 14597986 (3), 18570113 (3), 16116312 (2) (see all 33)
5q- syndrome	44.20	1	8602997 (1)
astrocytoma	42.93	9	16231009 (2), 10664248 (2), 9359863 (1), 8930892 (1) (see all 5)
arterial thrombosis	39.65	6	7796507 (3), 11727307 (1), 9432025 (1)
restenosis	34.73	22	9186620 (2), 14529396 (2), 18000795 (2), 8328214 (1) (see all 14)
necrosis	34.20	52	9435232 (1), 12975637 (1), 15289504 (1), 15897419 (1) (see all 43)
bernard-soulier syndrome	31.33	1	8110787 (1)
tumors	30.33	131	11278329 (4), 16608645 (4), 11395381 (3), 16707447 (2) (see all 87)
atherosclerotic plaque	29.82	3	14529396 (1), 12556215 (1), 18606675 (1)

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Human Gene Mutation Database: F2R
Human Genome Epidemiology Navigator: F2R (26 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/802 PubMed articles for F2R gene (see all 802 ):

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)^{1, 3, 4} Kahn M.L....Coughlin S.R. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{3, 4} Cargill M....Lander E.S. (1999)
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. (PubMed id 8136362)^{3, 4} Mathews I.I.... Fenton J.W. II (1994)
Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5. (PubMed id 8395910)^{2, 3} Bahou W.F....Demetrick D.J. (1993)
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. (PubMed id 1672265)^{3, 4} Vu T.-K.H.... Coughlin S.R. (1991)
Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. (PubMed id 15191806)^{1, 3} Junge C.E....Traynelis S.F. (2004)
Proteinase-activated receptor-1 (PAR(1)) and PAR(2) but not PAR(4) mediate contraction in human and guinea-pig gallbladders. (PubMed id 18179608)^{1, 3} Lee M.C. and Huang S.C. (2008)
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells. (PubMed id 18284602)^{1, 3} Bae J.S....Rezaie A.R. (2008)
Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro. (PubMed id 14507634)^{1, 3} O'Brien P.J....Christenson L.K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2149	HGNC: 3537	AceView: F2R	Ensembl:ENSG00000181104	euGenes: HUgn2149
ECgene: F2R	H-InvDB: F2R

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for F2R	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/f2r/

Licensable Technologies for F2R
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F2R:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F2R-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F2R		Antibodies for F2R
	Explore super-pooled esiRNAs		Proteins for F2R
	Lentivirus-delivered shRNAs for F2R		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (F2R)
	Antibodies (F2R)
	Chimera RNAi (F2R)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Thrombin Receptor)
	Antibodies (Thrombin Receptor)

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Antibodies for F2R

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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F2R Gene at Home site.
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F2R Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for F2R

Summaries
for F2R

Genomic Location
for F2R

Proteins
for F2R

Protein Domains/
Families
for F2R

Gene Function
for F2R

Pathways & Interactions
for F2R

Drugs & Compounds
for F2R

Transcripts
for F2R

Expression
for F2R

Orthologs
for F2R

Paralogs
for F2R

SNPs/Variants
for F2R

Disorders & Mutations
for F2R

Medical News
for F2R

Publications
for F2R

Search for F2R

Genome Databases showing F2R

Other Databases showing F2R

Specialized Databases showing F2R

Licensable Technologies
for F2R

Services
for F2R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F2R Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor F2R

Summariesfor F2R

Genomic Locationfor F2R

Proteinsfor F2R

Protein Domains/Familiesfor F2R

Gene Functionfor F2R

Pathways & Interactionsfor F2R

Drugs & Compoundsfor F2R

Transcriptsfor F2R

Expression for F2R

Orthologsfor F2R

Paralogsfor F2R

SNPs/Variantsfor F2R

Disorders & Mutationsfor F2R

Medical Newsfor F2R

Publicationsfor F2R

Search for F2R

Genome Databases showing F2R

Other Databases showing F2R

Specialized Databases showing F2R

Licensable Technologiesfor F2R

Servicesfor F2R

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F2R

Summaries
for F2R

Genomic Location
for F2R

Proteins
for F2R

Protein Domains/
Families
for F2R

Gene Function
for F2R

Pathways & Interactions
for F2R

Drugs & Compounds
for F2R

Transcripts
for F2R

Expression
for F2R

Orthologs
for F2R

Paralogs
for F2R

SNPs/Variants
for F2R

Disorders & Mutations
for F2R

Medical News
for F2R

Publications
for F2R

Licensable Technologies
for F2R

Services
for F2R