Aliases for F2R Gene
External Ids for F2R Gene
Previous GeneCards Identifiers for F2R Gene
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
GeneCards Summary for F2R Gene
F2R (Coagulation Factor II Thrombin Receptor) is a Protein Coding gene. Diseases associated with F2R include dyskeratosis congenita, autosomal dominant 1 and aplastic anemia. Among its related pathways are Calcium signaling pathway and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein alpha-subunit binding. An important paralog of this gene is GPR132.
UniProtKB/Swiss-Prot for F2R Gene
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.