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F2R Gene

protein-coding   GIFtS: 72
GCID: GC05P076047

Coagulation Factor II (Thrombin) Receptor

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coagulation Factor II (Thrombin) Receptor1 2     HTR2
CF2R2 3 5     Protease-Activated Receptor 12
PAR12 3 5     Proteinase-Activated Receptor 12
PAR-12 3     Coagulation Factor II Receptor3
TR2 3     Thrombin Receptor3

External Ids:    HGNC: 35371   Entrez Gene: 21492   Ensembl: ENSG000001811047   OMIM: 1879305   UniProtKB: P251163   

Export aliases for F2R gene to outside databases

Previous GC identifers: GC05P074817 GC05P076246 GC05P076050 GC05P076095 GC05P071219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for F2R Gene:
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response.
Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.
(provided by RefSeq, Jul 2008)

GeneCards Summary for F2R Gene:
F2R (coagulation factor II (thrombin) receptor) is a protein-coding gene. Diseases associated with F2R include 5q- syndrome, and bernard-soulier syndrome. GO annotations related to this gene include G-protein alpha-subunit binding and G-protein coupled receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide
hydrolysis. May play a role in platelets activation and in vascular development

summary for F2R Gene:
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors,
activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide
ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling.
Four subtypes of receptors have so far been cloned (PAR1-4). PAR1 is the most well characterized member of
this receptor family and is activated by the endogenous serine protease thrombin. Thrombin has a primary
role in vessel wound healing and revascularization and acts via PAR1 receptors on platelets, endothelial
cells, smooth muscle cells, neutrophils, leukocytes, neurons and glial cells to facilitate a coordinated
response to vessel damage. Thrombin-mediated PAR1 activation induces platelet aggregation. Thrombin
stimulates 5-HT, ATP and thromboxane A2 release, integrin alphaIIb/beta3 activation, and P-selectin and CD40
translocation to facilitate the binding of platelets to endothelial cells. Activation of endothelial cells
is a key component in clotting and wound healing, and is mediated by PAR1 stimulation. Activation of PAR1 by
thrombin stimulates von Willebrand factor release, tissue factor expression and adhesion molecule
expression, which further promotes clotting and coagulation as well as facilitating the rapid adherence of
neutrophils, monocytes and lymphocytes to endothelial cells. Thrombin has direct promitogenic activity in
fibroblasts, vascular smooth muscle cells, endothelial cells and some myeloid cells. Thrombin-mediated PAR1
activation also induces expression of promitogenic factors and their receptors such as PDGF/PDGFR and
ET-1/ETA and ET-B. PAR1 is known to couple to several heterotrimeric G proteins and regulates multiple
kinase signaling pathways including PI 3-K, Src family tyrosine kinases, JNK, Rho kinases, JAK2 and FAK.

Gene Wiki entry for F2R (Coagulation factor II receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the F2R gene promoter:
         Sp1   AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   CREB   deltaCREB   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): F2R promoter sequence
   Search Chromatin IP Primers for F2R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13

F2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2R gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P076047:  view genomic region     (about GC identifiers)

Start:
76,011,868 bp from pter      End:
76,031,606 bp from pter
Size:
19,739 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116 (See protein sequence)
Recommended Name: Proteinase-activated receptor 1 precursor  
Size: 425 amino acids; 47441 Da
Selected PDB 3D structures from and Proteopedia for F2R (see all 10):
1NRN (3D)        1NRO (3D)        1NRP (3D)        1NRQ (3D)        1NRR (3D)        3BEF (3D)    
Secondary accessions: Q53XV0 Q96RF7 Q9BUN4

Explore the universe of human proteins at neXtProt for F2R: NX_P25116

Explore proteomics data for F2R at MOPED

Post-translational modifications: 

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand1
  • Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and
    internalization of the receptor1
  • Glycosylation2 at Asn35, Asn62, Asn75, Asn250, Asn259
  • Modification sites at PhosphoSitePlus

  • See F2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001983.2  
    ENSEMBL proteins: 
     ENSP00000321326   ENSP00000426398  
    Reactome Protein details: P25116

    F2R Human Recombinant Protein Products:

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    Novus Biologicals F2R Proteins
    Novus Biologicals F2R Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    F2R Antibody Products:

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    R&D Systems Antibodies for F2R (PAR1)
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    Novus Biologicals F2R Antibodies
    Abcam antibodies for F2R
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    LSBio Antibodies in human, mouse, rat for F2R

    F2R Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    F2R: GPCR / Class A : Protease activated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAR1
    Protease-activated receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003912 Protea_act_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000935 Thrmbn_rcpt

    Graphical View of Domain Structure for InterPro Entry P25116

    ProtoNet protein and cluster: P25116

    2 Blocks protein domains:
    IPB000935 Thrombin receptor signature
    IPB003912 Protease activated receptor precursor signature


    UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
    Domain: The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor
    peptide known as parstatin
    Similarity: Belongs to the G-protein coupled receptor 1 family


    F2R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAR1_HUMAN, P25116
    Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide
    hydrolysis. May play a role in platelets activation and in vascular development

         Genatlas biochemistry entry for F2R:
    coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the common proximal
    breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding ISS--
    GO:0004930G-protein coupled receptor activity TAS17848177
    GO:0005102receptor binding IPI1672265
    GO:0005515protein binding IPI17848177
    GO:0015057thrombin receptor activity IDA10692450
         
    F2R for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for F2R:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for F2r) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system  tumorigenesis 

    F2R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for F2R: F2rtm1Pago F2rtm1Ajc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for F2R
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for F2R

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for F2R
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for F2R

    miRNA
    Products:
        
    miRTarBase miRNAs that target F2R:
    hsa-let-7a-5p (MIRT052570), hsa-mir-877-3p (MIRT037083)

    Block miRNA regulation of human, mouse, rat F2R using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate F2R (see all 19):
    hsa-miR-3685 hsa-miR-106a hsa-miR-93 hsa-miR-3662 hsa-miR-526b* hsa-miR-450b-5p hsa-miR-515-3p hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidF2R 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for F2R
    Predesigned siRNA for gene silencing in human, mouse, rat F2R

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for F2R

    Clone
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    OriGene clones in human, mouse for F2R (see all 7)
    OriGene ORF clones in mouse, rat for F2R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): F2R (NM_006140)
    Sino Biological Human cDNA Clone for F2R
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F2R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F2R

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for F2R
    Browse ESI BIO Cell Lines and PureStem Progenitors for F2R 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F2R


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAR1_HUMAN, P25116: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    golgi apparatus4
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005794Golgi apparatus TAS7961693
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1672265
    GO:0005901caveola IDA17848177

    F2R for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for F2R About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F2R
        Glioma Invasiveness
    p70S6K Signaling
    JAK-STAT Pathway
    Thrombin Signaling
    Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for F2R
        Cell adhesion Integrin inside-out signaling

    4 BioSystems Pathways for F2R
        GPCRs, Other
    Regulation of Actin Cytoskeleton
    Complement and Coagulation Cascades
    GPCRs, Class A Rhodopsin-like


    3 Reactome Pathways for F2R
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    Thrombin signalling through proteinase activated receptors (PARs)

    1 PharmGKB Pathway for F2R
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for F2R) (see all 7):
        Rap1 signaling pathway
    Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Endocytosis
    PI3K-Akt signaling pathway


    F2R for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including F2R: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for F2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for F2R (P251161, 3 ENSP000003213264) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=2 STRING: ENSP00000308541
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    CAPN1P073843, ENSP000002792474I2D: score=1 STRING: ENSP00000279247
    GNA15P306793, ENSP000002629584I2D: score=1 STRING: ENSP00000262958
    GNAT1P114883, ENSP000002324614I2D: score=1 STRING: ENSP00000232461
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    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity ISS--
    GO:0002248connective tissue replacement involved in inflammatory response wound healing IDA9639571
    GO:0003105negative regulation of glomerular filtration ISS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IDA10692450
    GO:0006954inflammatory response ISS--

    F2R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for F2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SCH 79797 dihydrochloride Potent, selective non-peptide PAR1 antagonist [245520-69-8]
    SLIGKV-NH2PAR2 receptor agonist[190383-13-2]
    TFLLR-NH2PAR1-activating peptide[197794-83-5]
    2-Furoyl-LIGRLO-amidePotent and selective PAR2 agonist[729589-58-6]
    TRAP-6PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist[141136-83-6]

    1 DrugBank Compound for F2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Streptokinase-- 9002-01-1targetcleavage10666203

    5 IUPHAR Ligands for F2R (PAR1)    About this table
    LigandTypeActionAffinityPubmed IDs
    SCH530348
    AntagonistAntagonist8.0918447380
    [3H]haTRAP
    AgonistAgonist7.829203642
    RWJ-56110
    AntagonistAntagonist6.3610535908
    TFLLR-NH2
    AgonistFull agonist5.4111877318
    atopaxar
    AntagonistAntagonist5.4119572075

    Selected Novoseek inferred chemical compound relationships for F2R gene (see all 118)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fllrn 84.6 6 16427862 (2), 10917956 (1), 7834643 (1)
    hirudin 84.4 31 19929245 (3), 15118533 (2), 1654318 (2), 9639571 (1) (see all 21)
    sfflrnp 78.6 2 8074233 (1), 8074680 (1)
    cangrelor 77.1 2 18657683 (1), 18462654 (1), 18369175 (1), 18991794 (1)
    ppack 70.9 3 9083795 (1), 10404777 (1)
    serine 70 40 15191806 (2), 14559973 (2), 10908720 (2), 12030612 (1) (see all 32)
    prasugrel 68.4 4 18462654 (1), 18369175 (1), 18991794 (1)
    adp 64.3 40 12871418 (3), 15078882 (3), 17675219 (2), 11722114 (2) (see all 26)
    fibrinogen 58.9 38 10891092 (4), 10395938 (4), 11460501 (2), 17115723 (2) (see all 25)
    clopidogrel 58.6 6 16194864 (2), 18520610 (1), 16837456 (1), 15477442 (1) (see all 5)



    F2R for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for F2R gene: 
    NM_001992.3  

    Unigene Cluster for F2R:

    Coagulation factor II (thrombin) receptor
    Hs.482562  [show with all ESTs]
    Unigene Representative Sequence: NM_001992
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319211(uc003ken.4) ENST00000505600
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat F2R using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate F2R (see all 19):
    hsa-miR-3685 hsa-miR-106a hsa-miR-93 hsa-miR-3662 hsa-miR-526b* hsa-miR-450b-5p hsa-miR-515-3p hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidF2R 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat F2R
    Clone
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    OriGene clones in human, mouse for F2R (see all 7)
    OriGene ORF clones in mouse, rat for F2R
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): F2R (NM_006140)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for F2R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F2R
    Primer
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    OriGene qPCR primer pairs and template standards for F2R
    OriGene qSTAR qPCR primer pairs in human, mouse for F2R
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat F2R
      QuantiTect SYBR Green Assays in human, mouse, rat F2R
      QuantiFast Probe-based Assays in human, mouse, rat F2R

    Additional mRNA sequence: 

    AK297131.1 AK308169.1 AK314202.1 AY771596.1 BC002464.2 BC016059.1 BC051909.1 BT007279.1 
    M62424.1 M93111.1 S76625.1 

    12 DOTS entries:

    DT.453981  DT.100786133  DT.120839242  DT.92066564  DT.102828402  DT.120839109  DT.120839110  DT.120839127 
    DT.120839266  DT.86843855  DT.121073993  DT.87046583 

    Selected AceView cDNA sequences (see all 117):

    BF438574 CA438126 BC016059 BP347223 N43757 CA424375 BM756571 AU123806 
    BQ001546 BM479604 AL045309 AI921649 CA434342 AA450199 BU616929 AU142813 
    BG678898 BC002464 BM994328 BT007279 CA437630 BC051909 AI520885 BP348607 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for F2R    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:        -               


    ECgene alternative splicing isoforms for F2R

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    F2R expression in normal human tissues (normalized intensities)      F2R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTCACAA
    F2R Expression
    About this image


    F2R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    F2R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    F2R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482562

    UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116
    Tissue specificity: Platelets and vascular endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including F2R: 
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              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for F2R gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F2r1 , 5 coagulation factor II (thrombin) receptor1, 5 79.87(n)1
    79.48(a)1
      13 (50.21 cM)5
    140621  NM_010169.31  NP_034299.21 
     956017895 
    chicken
    (Gallus gallus)
    Aves F2R1 coagulation factor II (thrombin) receptor 63.18(n)
    61.19(a)
      427212  XM_004937337.1  XP_004937394.1 
    lizard
    (Anolis carolinensis)
    Reptilia F2R6
    coagulation factor II (thrombin) receptor
    62(a)
    1 ↔ 1
    2(14202163-14220165)
    African clawed frog
    (Xenopus laevis)
    Amphibia f2r-A-prov2 coagulation factor II (thrombin) receptor 71.67(n)    U09632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii f2r1 coagulation factor II (thrombin) receptor 56.88(n)
    48.1(a)
      558477  NM_001114846.1  NP_001108318.1 


    ENSEMBL Gene Tree for F2R (if available)
    TreeFam Gene Tree for F2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for F2R gene
    FFAR32  GPR42  GPR682  P2RY82  GPR652  F2RL12  FFAR22  F2RL22  
    GPR1322  FFAR12  GPR422  F2RL32  
    7 SIMAP similar genes for F2R using alignment to 2 protein entries:     PAR1_HUMAN (see all proteins):
    HTR    F2RL1    LPAR6    P2RY8    F2RL2    F2RL3
    GPR17

    F2R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for F2R (see all 471)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114357771,2
    C--76015413(+) AAAAA-/AGAGGT 1 -- int1 trp30--------
    rs38368271,2
    C--76018342(+) TACTT-/TCCTGC 1 -- int10--------
    rs114590241,2
    C--76018775(+) AAAAAA/-GAATT 1 -- int1 trp32Minor allele frequency- -:0.25NA 4
    rs22277791,2
    C,F--76021447(+) CTACAT/-TTTTT 1 -- int1 trp37Minor allele frequency- -:0.18NS NA CSA 170
    rs777682231,2
    --76021454(+) TTTTTC/TTTTTC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs22277821,2
    C,F--76022213(+) tagccG/Aggcgc 1 -- int15Minor allele frequency- A:0.02NS NA WA 146
    rs22277901,2
    C,F--76025244(+) tcagaC/Tgtatg 1 -- int16Minor allele frequency- T:0.14NS NA CSA WA 256
    rs789655721,2
    F--76303550(+) GAACTA/GTGTAA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs22277431,2
    C,F,H--76303551(+) AACTAT/CGTAAT 1 -- us2k113Minor allele frequency- C:0.06NS EA NA WA 720
    rs1876940451,2
    --76303569(+) GTTCAC/TATTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for F2R (76011868 - 76031606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for F2R:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730323CNV Deletion23290073
    esv2730324CNV Deletion23290073
    dgv6186n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): F2R
    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for F2R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187930    OMIM disorders: --

    Selected diseases for F2R (see all 109):    About MalaCards
    5q- syndrome    bernard-soulier syndrome    glanzmann's thrombasthenia    thrombasthenia
    crescentic glomerulonephritis    blastoma    hepatitis a    somatostatin analog
    thromboembolism    prader-willi syndrome    thrombophilia    venous thrombosis
    gaucher's disease    venous thromboembolism    pituitary tumors    glomerulonephritis
    irritable bowel syndrome    antiphospholipid syndrome    thrombocytopenia    squamous cell carcinoma of the head and neck

    2 diseases from the University of Copenhagen DISEASES database for F2R:
    Vascular disease     Heart disease

    F2R for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for F2R gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 57.7 32 20445954 (3), 10669659 (2), 14529396 (2), 11408522 (2) (see all 19)
    inflammation 51.8 66 15545995 (3), 14597986 (3), 18570113 (3), 16116312 (2) (see all 39)
    astrocytoma 42.2 9 16231009 (2), 10664248 (2), 9359863 (1), 8930892 (1) (see all 5)
    arterial thrombosis 41.6 10 7796507 (3), 20144050 (1), 19699853 (1), 9432025 (1) (see all 5)
    5q- syndrome 41.1 1 8602997 (1)
    restenosis 35.9 22 9186620 (2), 14529396 (2), 18000795 (2), 8328214 (1) (see all 14)
    necrosis 34.7 58 9435232 (1), 12975637 (1), 15289504 (1), 15897419 (1) (see all 49)
    tumors 33.7 151 11278329 (4), 16608645 (4), 11395381 (3), 16707447 (2) (see all 99)
    atherosclerosis 32.3 15 9186620 (2), 18000795 (2), 7863981 (1), 15063481 (1) (see all 11)
    metastasis 32.1 67 19538737 (6), 16608645 (3), 17706138 (3), 19170048 (3) (see all 30)

    Genetic Association Database (GAD): F2R
    Human Genome Epidemiology (HuGE) Navigator: F2R (56 documents)

    Export disorders for F2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for F2R gene, integrated from 10 sources (see all 1092):
    (articles sorted by number of sources associating them with F2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)1, 2, 9 Kahn M.L....Coughlin S.R. (J. Clin. Invest. 1999)
    2. Retrospective analysis of coagulation factor II receptor (F2R) sequence variation and coronary heart disease in hypertensive patients. (PubMed id 17347481)1, 4, 9 Gigante B....Trimarco B. (Arterioscler. Thromb. Vasc. Biol. 2007)
    3. The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression. (PubMed id 22659187)1, 2 Zampatis D.E.... Schulein R. (FEBS Lett. 2012)
    4. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Platelet gene polymorphisms and risk of bleeding in patients undergoing elective coronary angiography: a genetic substudy of the PRAGUE-8 trial. (PubMed id 20691446)1, 4 Motovska Z....Widimsky P. (Atherosclerosis 2010)
    8. The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men. (PubMed id 20585578)1, 4 Gigante B....de Faire U. (PLoS ONE 2010)
    9. Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels. (PubMed id 19404549)1, 4 Gigante B....de Faire U. (Thromb. Haemost. 2009)
    10. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1, 4 Silander K....Peltonen L. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2149 HGNC: 3537 AceView: F2R Ensembl:ENSG00000181104 euGenes: HUgn2149
    ECgene: F2R Kegg: 2149 H-InvDB: F2R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for F2R Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for F2R Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/f2r/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for F2R gene:
    Search GeneIP for patents involving F2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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