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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

F2R Gene

protein-coding GIFtS: 67
GCID: GC05P076047

coagulation factor II (thrombin) receptor

Explore 121 diseases affiliated with
F2R via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coagulation Factor II (Thrombin) Receptor¹ ²		HTR²
CF2R¹ ² ³ ⁵		Protease-Activated Receptor 1²
PAR1¹ ² ³ ⁵		Proteinase-Activated Receptor 1²
PAR-1¹ ² ³		Coagulation Factor II Receptor³
TR¹ ² ³		Thrombin Receptor³

External Ids:	HGNC: 3537¹	Entrez Gene: 2149²	Ensembl: ENSG00000181104⁷	OMIM: 187930⁵	UniProtKB: P25116³

Export aliases for F2R gene to outside databases

Previous GC identifers: GC05P074817 GC05P076246 GC05P076050 GC05P076095 GC05P071219

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for F2R:

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response.

Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide

hydrolysis. May play a role in platelets activation and in vascular development

summary for F2R:

Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors,

activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide

ligand, which interacts with the receptor within extracellular loop-2 to affect transmembrane signaling.

Four subtypes of receptors have so far been cloned (PAR1-4). PAR1 is the most well characterized member of

this receptor family and is activated by the endogenous serine protease thrombin. Thrombin has a primary

role in vessel wound healing and revascularization and acts via PAR1 receptors on platelets, endothelial

cells, smooth muscle cells, neutrophils, leukocytes, neurons and glial cells to facilitate a coordinated

response to vessel damage. Thrombin-mediated PAR1 activation induces platelet aggregation. Thrombin

stimulates 5-HT, ATP and thromboxane A2 release, integrin alphaIIb/beta3 activation, and P-selectin and CD40

translocation to facilitate the binding of platelets to endothelial cells. Activation of endothelial cells

is a key component in clotting and wound healing, and is mediated by PAR1 stimulation. Activation of PAR1 by

thrombin stimulates von Willebrand factor release, tissue factor expression and adhesion molecule

expression, which further promotes clotting and coagulation as well as facilitating the rapid adherence of

neutrophils, monocytes and lymphocytes to endothelial cells. Thrombin has direct promitogenic activity in

fibroblasts, vascular smooth muscle cells, endothelial cells and some myeloid cells. Thrombin-mediated PAR1

activation also induces expression of promitogenic factors and their receptors such as PDGF/PDGFR and

ET-1/ETA and ET-B. PAR1 is known to couple to several heterotrimeric G proteins and regulates multiple

kinase signaling pathways including PI 3-K, Src family tyrosine kinases, JNK, Rho kinases, JAK2 and FAK.

Gene Wiki entry for F2R (Coagulation factor II receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the F2R gene promoter:
Sp1 AP-2alpha isoform 3 Nkx2-5 AP-2alpha isoform 2 CREB deltaCREB AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): F2R promoter sequence

Search SABiosciences Chromatin IP Primers for F2R

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F2R

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13

F2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F2R gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P076047: view genomic region (about GC identifiers)

Start:	76,011,868 bp from pter	End:	76,031,606 bp from pter
Size:	19,739 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116 (See protein sequence)

Recommended Name: Proteinase-activated receptor 1 precursor

Size: 425 amino acids; 47441 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

6/10 PDB 3D structures from and Proteopedia for F2R (see all 10):

1NRN (3D)

1NRO (3D)

1NRP (3D)

1NRQ (3D)

1NRR (3D)

3BEF (3D)

Secondary accessions: Q53XV0 Q96RF7 Q9BUN4

Explore the universe of human proteins at neXtProt for F2R: NX_P25116

Post-translational modifications:

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand¹

Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization

of the receptor¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25116

F2R Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001983.2

ENSEMBL proteins:

ENSP00000321326 ENSP00000426398

Reactome Protein details: P25116
Human Recombinant Protein Products:

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	Uscn Proteins for F2R

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005794	Golgi apparatus	TAS	7961693
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1672265
GO:0005901	caveola	IDA	17848177

F2R for ontologies About GeneDecksing

F2R Antibody Products:

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	Uscn ELISAs and CLIAs for F2R

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

F2R for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR003912 Protea_act_rcpt

IPR000276 GPCR_Rhodpsn

IPR000935 Thrmbn_rcpt

Graphical View of Domain Structure for InterPro Entry P25116

ProtoNet protein and cluster: P25116

2 Blocks protein families:

IPB000935 Thrombin receptor signature

IPB003912 Protease activated receptor precursor signature

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide

hydrolysis. May play a role in platelets activation and in vascular development

Genatlas biochemistry entry for F2R:

coagulation factor II (thrombin) receptor,proteinase activated receptor 1 (centromeric to the common proximal

breakpoint and unlikely involved in 5q- syndrome), G protein coupled receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone: F2R Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat F2R
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		hsa-miR-3685 hsa-miR-106a hsa-miR-93 hsa-miR-3662 hsa-miR-526b* hsa-miR-450b-5p hsa-miR-515-3p hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: F2R 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 9): F2R (NM_006140)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F2R

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001965	G-protein alpha-subunit binding	ISS	--
GO:0004872	receptor activity	--	--
GO:0004930	G-protein coupled receptor activity	TAS	17848177
GO:0005102	receptor binding	IPI	1672265
GO:0005515	protein binding	IPI	--

F2R for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for F2R:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for F2R: F2r^tm1Pago F2r^tm1Ajc
15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for F2r) (see all 16):

cardiovascular system	cellular	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	limbs/digits/tail	liver/biliary system
mortality/aging	nervous system	no phenotypic analysis	reproductive system	tumorigenesis

F2R for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
Peptide ligand-binding receptors	0.61

Activation of beta-arrestin-1-bound Src kinase

	Activated Src activates ERK	1.00			Src bound to beta-arrestin-2 is not activated	0.67
	Activation of beta-arrestin-1-bound Src kinase	1.00

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Cell adhesion_Integrin inside-out signaling

Cell adhesion_Integrin inside-out signaling

1.00

Cell adhesion Integrin inside-out signaling

0.99

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for F2R

	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
	Cell adhesion Integrin inside-out signaling

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F2R

	Glioma Invasiveness
	p70S6K Signaling
	JAK-STAT Pathway
	Thrombin Signaling
	Transendothelial Migration of Leukocytes

1 GeneGo (Thomson Reuters) Pathway for F2R

Cell adhesion Integrin inside-out signaling

4 BioSystems Pathways for F2R

	GPCRs, Class A Rhodopsin-like
	GPCRs, Other
	Regulation of Actin Cytoskeleton
	Complement and Coagulation Cascades

5/14 Reactome Pathways for F2R (see all 14)

	GPCR downstream signaling
	Hemostasis
	Peptide ligand-binding receptors
	Activation of beta-arrestin-1-bound Src kinase
	Gastrin-CREB signalling pathway via PKC and MAPK

1 PharmGKB Pathway for F2R

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

5 Kegg Pathways (Kegg details for F2R):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Complement and coagulation cascades
	Regulation of actin cytoskeleton

F2R for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for F2R

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/169 Interacting proteins for F2R (P25116^{1, 3} ENSP00000321326⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 169)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
F2	P00734³, ENSP00000308541⁴	I2D: score=2 STRING: ENSP00000308541
GPRASP1	Q5JY77³, ENSP00000355146⁴	I2D: score=2 STRING: ENSP00000355146
CAPN1	P07384³, ENSP00000279247⁴	I2D: score=1 STRING: ENSP00000279247
GNA15	P30679³, ENSP00000262958⁴	I2D: score=1 STRING: ENSP00000262958
GNAT1	P11488³, ENSP00000232461⁴	I2D: score=1 STRING: ENSP00000232461

About this table

Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	ISS	--
GO:0002248	connective tissue replacement involved in inflammatory response wound healing	IDA	9639571
GO:0003105	negative regulation of glomerular filtration	ISS	--
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	10692450
GO:0006954	inflammatory response	ISS	--

F2R for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

F2R for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for F2R available from Tocris Bioscience About this table

Compound	Action	CAS #
SCH 79797 dihydrochloride	Potent, selective non-peptide PAR1 antagonist	[245520-69-8]
TFLLR-NH2	PAR1-activating peptide	[197794-83-5]
Parstatin (mouse)	Peptide cleaved from PAR1 upon receptor activation	[1065756-01-5]
Parstatin (human)	Peptide cleaved from PAR1 upon receptor activation	[1065755-99-8]
TRAP-6	PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist	[141136-83-6]

1 DrugBank Compound for F2R About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Streptokinase	--	9002-01-1	target	cleavage	10666203

10/118 Novoseek chemical compound relationships for F2R gene (see all 118) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fllrn	84.6	6	16427862 (2), 10917956 (1), 7834643 (1)
hirudin	84.4	31	19929245 (3), 15118533 (2), 1654318 (2), 9639571 (1) (see all 21)
sfflrnp	78.6	2	8074233 (1), 8074680 (1)
cangrelor	77.1	2	18657683 (1), 18462654 (1), 18369175 (1), 18991794 (1)
ppack	70.9	3	9083795 (1), 10404777 (1)
serine	70	40	15191806 (2), 14559973 (2), 10908720 (2), 12030612 (1) (see all 32)
prasugrel	68.4	4	18462654 (1), 18369175 (1), 18991794 (1)
adp	64.3	40	12871418 (3), 15078882 (3), 17675219 (2), 11722114 (2) (see all 26)
fibrinogen	58.9	38	10891092 (4), 10395938 (4), 11460501 (2), 17115723 (2) (see all 25)
clopidogrel	58.6	6	16194864 (2), 18520610 (1), 16837456 (1), 15477442 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about F2R / PAR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for F2R gene:

NM_001992.3

Unigene Cluster for F2R:

Coagulation factor II (thrombin) receptor

Hs.482562 [show with all ESTs]

Unigene Representative Sequence: NM_001992

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000319211(uc003ken.4) ENST00000505600

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		hsa-miR-3685 hsa-miR-106a hsa-miR-93 hsa-miR-3662 hsa-miR-526b* hsa-miR-450b-5p hsa-miR-515-3p hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: F2R 3' UTR sequence

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Additional cDNA sequence:

AK297131.1 AK308169.1 AK314202.1 AY771596.1 BC002464.2 BC016059.1 BC051909.1 BT007279.1

M62424.1 M93111.1 S76625.1

12 DOTS entries:

DT.453981 DT.100786133 DT.120839242 DT.92066564 DT.102828402 DT.120839109 DT.120839110 DT.120839127

DT.120839266 DT.86843855 DT.121073993 DT.87046583

24/117 AceView cDNA sequences (see all 117):

BG678898 BQ001546 BC002464 CA434342 AI921649 BC051909 AI520885 BM994328

CA437630 AL045309 BM479604 BP347223 AA450199 BU616929 AU123806 N43757

AU142813 BT007279 BM756571 CA424375 BC016059 CA438126 BF438574 M62424

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for F2R About this scheme

ExUns:	1	^	2	^	3a	·	3b
SP1:
SP2:			-

ECgene alternative splicing isoforms for F2R

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

F2R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTCACAA

About this image

F2R expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Amacrine, Retina

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

See F2R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for F2R

SOURCE GeneReport for Unigene cluster: Hs.482562

UniProtKB/Swiss-Prot: PAR1_HUMAN, P25116

Tissue specificity: Platelets and vascular endothelial cells

SABiosciences Expression via Pathway-Focused PCR Arrays including F2R:

G Protein Coupled Receptors 384HT in human mouse rat

Endothelial Cell Biology in human mouse rat

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F2R

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for F2R gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F2R¹	coagulation factor II (thrombin) receptor	63.16(n) 61.12(a)		427212 XM_424799.3 XP_424799.2
lizard (Anolis carolinensis)	Reptilia	F2R⁶	--	65(a)	1 ↔ 1	2(14206745-14207680)
African clawed frog (Xenopus laevis)	Amphibia	f2r-A-prov²	coagulation factor II (thrombin) receptor	71.67(n)		U09632.1
zebrafish (Danio rerio)	Actinopterygii	f2r¹	coagulation factor II (thrombin) receptor	56.1(n) 47.54(a)		558477 NM_001114846.1 NP_001108318.1

ENSEMBL Gene Tree for F2R (if available)
TreeFam Gene Tree for F2R (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for F2R gene

GPR4² FFAR3² GPR68² P2RY8² F2RL1² GPR65² FFAR2² F2RL2²

GPR132² FFAR1² GPR42² F2RL3²

8 SIMAP similar genes for F2R using alignment to 2 protein entries: PAR1_HUMAN (see all proteins):

HTR F2RL1 LPAR6 P2RY5 P2RY8 F2RL2

F2RL3 GPR17

F2R for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78965572^1,2		--	71217726(+)	`GAACTA/GTGTAA`	1	--	us2k¹		1		EA	120
rs2227743^1,2	C,F,H,	--	71217727(+)	`AACTAT/CGTAAT`	1	--	us2k¹		13		NS EA NA WA	720
rs78065563^1,2		--	71217751(+)	`ATTTAC/TTCTTG`	1	--	us2k¹		0	--	--	--	--
rs2227817^1,2	C,	--	71218129(+)	`GGGACC/ACATTT`	1	--	us2k¹		3		NS NA	214
rs112515244^1,2		--	71218310(+)	`CCTGGC/TGCGGT`	1	--	us2k¹		1		CSA	2
rs2227818^1,2	C,F,	--	71218677(+)	`TGCGCA/GGGTGA`	1	--	us2k¹		5		NS NA	218
rs116541908^1,2	C,F,	--	71218955(+)	`AGTCCC/TTTTTA`	1	--	us2k¹		1		WA	118
rs11267092^1,2	C,F	--	71219123(+)	`GAAGC-/GGCCG CGGGAAGCAGCCT`	1	--	us2k¹		2		NS	76
rs189669041^1,2	C,	--	71219484(+)	`GCTTGA/GACCCT`	1	--	ut5¹		0	--	--	--	--
rs73127597^1,2	C,F,	--	71219495(+)	`GATCTT/CACCCG`	1	--	ut5¹		3		WA CSA EA	124

HapMap Linkage Disequilibrium report for F2R (76011868 - 76031606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for F2R: --
Human Gene Mutation Database (HGMD): F2R

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing F2R

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

F2R for disorders           About GeneDecksing

OMIM gene information: 187930    OMIM disorders: --

20/121 diseases for F2R (see all 121):    About MalaCards

peroxisome biogenesis disorders peroxisomal biogenesis disorder prader-willi syndrome glanzmann's thrombasthenia

fibrous histiocytoma non-small cell lung carcinoma malignant fibrous histiocytoma thrombasthenia

clear cell renal cell carcinoma major depressive disorder coronary heart disease inflammatory bowel disease

myocardial infarction crescentic glomerulonephritis squamous cell carcinoma irritable bowel syndrome

venous thrombosis histiocytoma oral squamous cell carcinoma acute myocardial infarction

1 disease from the University of Copenhagen DISEASES database for F2R:

pre-eclampsia

10/94 Novoseek disease relationships for F2R gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombosis	57.7	32	20445954 (3), 10669659 (2), 14529396 (2), 11408522 (2) (see all 19)
inflammation	51.8	66	15545995 (3), 14597986 (3), 18570113 (3), 16116312 (2) (see all 39)
astrocytoma	42.2	9	16231009 (2), 10664248 (2), 9359863 (1), 8930892 (1) (see all 5)
arterial thrombosis	41.6	10	7796507 (3), 20144050 (1), 19699853 (1), 9432025 (1) (see all 5)
5q- syndrome	41.1	1	8602997 (1)
restenosis	35.9	22	9186620 (2), 14529396 (2), 18000795 (2), 8328214 (1) (see all 14)
necrosis	34.7	58	9435232 (1), 12975637 (1), 15289504 (1), 15897419 (1) (see all 49)
tumors	33.7	151	11278329 (4), 16608645 (4), 11395381 (3), 16707447 (2) (see all 99)
atherosclerosis	32.3	15	9186620 (2), 18000795 (2), 7863981 (1), 15063481 (1) (see all 11)
metastasis	32.1	67	19538737 (6), 16608645 (3), 17706138 (3), 19170048 (3) (see all 30)

Human Genome Epidemiology (HuGE) Navigator: F2R (56 documents)

Export disorders for F2R gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for F2R gene, integrated from 9 sources (see all 1067):
(articles sorted by number of sources associating them with F2R)

Utopia: connect your pdf to the dynamic
world of online information

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PubMed id 10079109)^{1, 2, 9} Kahn M.L....Coughlin S.R. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{1, 2} Cargill M....Lander E.S. (1999)
Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. (PubMed id 8955127)^{1, 2} Shapiro M.J....Coughlin S.R. (1996)
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. (PubMed id 8136362)^{1, 2} Mathews I.I.... Fenton J.W. II (1994)
Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5. (PubMed id 8395910)^{1, 3} Bahou W.F....Demetrick D.J. (1993)
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. (PubMed id 1672265)^{1, 2} Vu T.-K.H.... Coughlin S.R. (1991)
Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. (PubMed id 15191806)^{1, 9} Junge C.E....Traynelis S.F. (2004)
PAR1 is selectively over expressed in high grade brea st cancer patients: a cohort study. (PubMed id 19538737)^{1, 9} HernA!ndez N.A....PAcrez V.M. (2009)
Protease-activated receptor-1 (PAR-1) promotes the mo tility of human melanomas and is associated to their metastatic phenotype. (PubMed id 20084489)^{1, 9} Silini A....Giavazzi R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2149	HGNC: 3537	AceView: F2R	Ensembl:ENSG00000181104	euGenes: HUgn2149
ECgene: F2R	Kegg: 2149	H-InvDB: F2R

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for F2R	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for F2R	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/f2r/

Intellectual Property for F2R gene
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Patent Information for F2R gene:
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GeneCards and IP:
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coagulation factor II (thrombin) receptor

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F2R Gene

coagulation factor II (thrombin) receptor

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