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F13B Gene

protein-coding   GIFtS: 60
GCID: GC01M197008

Coagulation Factor XIII, B Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coagulation Factor XIII, B Polypeptide1 2     FXIIIB2
Fibrin-Stabilizing Factor B Subunit2 3     TGase2
Protein-Glutamine Gamma-Glutamyltransferase B Chain2 3     Coagulation Factor XIII B Chain2
Transglutaminase B Chain2 3     

External Ids:    HGNC: 35341   Entrez Gene: 21652   Ensembl: ENSG000001432787   OMIM: 1345805   UniProtKB: P051603   

Export aliases for F13B gene to outside databases

Previous GC identifers: GC01M194735 GC01M192466 GC01M193474 GC01M194296 GC01M193739 GC01M195274 GC01M168165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for F13B Gene:
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become
activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2
B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may
serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical
to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the
presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme,
factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of
gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor
XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and
B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in
a lifelong bleeding tendency, defective wound healing, and habitual abortion. (provided by RefSeq, Jul 2008)

GeneCards Summary for F13B Gene:
F13B (coagulation factor XIII, B polypeptide) is a protein-coding gene. Diseases associated with F13B include factor xiii subunit b deficiency, and factor xiiib deficiency. An important paralog of this gene is CFHR4.

UniProtKB/Swiss-Prot: F13B_HUMAN, P05160
Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and
regulate the rate of transglutaminase formation by thrombin

Gene Wiki entry for F13B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the F13B gene promoter:
         Pbx1a   Pax-5   HNF-4alpha2   HNF-4alpha1   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidF13B promoter sequence
   Search Chromatin IP Primers for F13B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat F13B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q32.1   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31-q32.1

F13B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
F13B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M197008:  view genomic region     (about GC identifiers)

Start:
197,008,321 bp from pter      End:
197,036,397 bp from pter
Size:
28,077 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F13B_HUMAN, P05160 (See protein sequence)
Recommended Name: Coagulation factor XIII B chain precursor  
Size: 661 amino acids; 75511 Da
Subunit: Tetramer of two A chains and two B chains
Secondary accessions: A8K3E5 Q5VYL5

Explore the universe of human proteins at neXtProt for F13B: NX_P05160

Explore proteomics data for F13B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn162, Asn545
  • Modification sites at PhosphoSitePlus

  • See F13B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001985.2  
    ENSEMBL proteins: 
     ENSP00000356382  
    Reactome Protein details: P05160

    F13B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P05160

    ProtoNet protein and cluster: P05160

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: F13B_HUMAN, P05160
    Similarity: Contains 10 Sushi (CCP/SCR) domains


    F13B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F13B_HUMAN, P05160
    Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and
    regulate the rate of transglutaminase formation by thrombin

         Genatlas biochemistry entry for F13B:
    coagulation factor XIII,B polypeptide,non catalytic (80kDa)

    Phenotypes:
         2 GenomeRNAi human phenotypes for F13B:
     Decreased number of cells in m  Increased gamma-H2AX phosphory 

    Animal Models:
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    Block miRNA regulation of human, mouse, rat F13B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate F13B:
    hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidF13B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F13B_HUMAN, P05160: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    F13B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for F13B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of Fibrin Clot (Clotting Cascade)
    Formation of Fibrin Clot (Clotting Cascade)0.51
    Common Pathway0.00
    Blood Clotting Cascade0.42
    Extrinsic Prothrombin Activation Pathway0.00
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    3Collagen biosynthesis and modifying enzymes
    Intrinsic Prothrombin Activation Pathway0.39
    Blood Coagulation Cascade0.38
    4Prostate Cancer
    Prostate Cancer0.32
    Steroid Biosynthesis0.00
    5Hemostasis
    Hemostasis0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for F13B
        Extrinsic Prothrombin Activation Pathway
    Blood Coagulation Cascade
    Intrinsic Prothrombin Activation Pathway

    4 BioSystems Pathways for F13B
        Blood Clotting Cascade
    Complement and Coagulation Cascades
    Prostate Cancer
    Steroid Biosynthesis


    1 Reactome Pathway for F13B
        Common Pathway


    1 Kegg Pathway  (Kegg details for F13B):
        Complement and coagulation cascades


    F13B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for F13B
    Interactions:

        Search GeneGlobe Interaction Network for F13B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for F13B (P051603 ENSP000003563824) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F13A1P004883, ENSP000002648704I2D: score=2 STRING: ENSP00000264870
    FGGP026793, ENSP000003368294I2D: score=2 STRING: ENSP00000336829
    F10ENSP000003647094STRING: ENSP00000364709
    F2ENSP000003085414STRING: ENSP00000308541
    F5ENSP000003567714STRING: ENSP00000356771
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--

    F13B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for F13B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for F13B gene: 
    NM_001994.2  

    Unigene Cluster for F13B:

    Coagulation factor XIII, B polypeptide
    Hs.435782  [show with all ESTs]
    Unigene Representative Sequence: NM_001994
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367412(uc001gtt.1) ENST00000490002
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate F13B:
    hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidF13B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat F13B
      QuantiFast Probe-based Assays in human, mouse, rat F13B

    Additional mRNA sequence: 

    AK290560.1 M14057.1 

    2 DOTS entries:

    DT.205660  DT.40130708 

    8 AceView cDNA sequences:

    R28976 BV178758 BV183392 BX510295 BG565816 M14057 BG200902 NM_001994 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    F13B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    F13B Expression
    About this image

    F13B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    F13B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435782
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for F13B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia F13b1 , 5 coagulation factor XIII, beta subunit1, 5 80.74(n)1
    77.31(a)1
      1 (61.57 cM)5
    140601  NM_031164.21  NP_112441.21 
     1395017075 
    chicken
    (Gallus gallus)
    Aves F13B1 coagulation factor XIII, B polypeptide 61.42(n)
    49.51(a)
      424355  XM_422198.4  XP_422198.4 
    lizard
    (Anolis carolinensis)
    Reptilia F13B6
    coagulation factor XIII, B polypeptide
    49(a)
    1 ↔ 1
    GL343432.1(225922-249641)
    zebrafish
    (Danio rerio)
    Actinopterygii f13b6
    coagulation factor XIII, B polypeptide
    26(a)
    many ↔ many
    22(24307815-24314511) ENSDARG00000091868


    ENSEMBL Gene Tree for F13B (if available)
    TreeFam Gene Tree for F13B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for F13B gene
    CFHR42  CFHR22  CFHR52  CFHR32  CFH2  CFHR12  

    F13B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for F13B (see all 667)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0074754
    Factor XIII subunit B deficiency (FA13BD)4--see VAR_0074752 C F mis40--------
    rs60031,2,,4
    C,F,O,A,Hother1203571910(-) CATGCA/GTTATG 2 H R mis1 ese343Minor allele frequency- G:0.25MN CSA EU CSAM NA NS EA WA 9632
    rs113112631,2
    C,F--168167970(+) GTATG-/CCCCTC 1 -- int15Minor allele frequency- C:0.29NA NS 98
    rs2020333811,2
    C--168167973(+) TGCCCC/TTNNNN 1 -- int10--------
    rs175494161,2
    C--168172946(-) GTTTAT/ACAGCT 1 -- int12Minor allele frequency- A:0.01NS 92
    rs175497831,2
    C--168173331(-) CTTTTT/ATGGTT 1 -- int12Minor allele frequency- A:0.01NS 92
    rs66691761,2
    C,F--168175479(+) aagtaT/Cgaaaa 1 -- int13Minor allele frequency- C:0.02NA NS 94
    rs175143171,2
    C,F--168179607(-) GTGTG-/TGAG  
            
    AGAAG
    1 -- int12Minor allele frequency- TGAG:0.25NS 82
    rs780813571,2
    C--168179608(+) TTCTCA/TCACAC 1 -- int10--------
    rs779393941,2
    C--168179615(+) ACACAC/TATATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for F13B (197008321 - 197036397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for F13B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1543078CNV Insertion17803354
    dgv514n71CNV Loss21882294
    nsv873063CNV Loss21882294
    nsv873066CNV Loss21882294
    nsv873064CNV Gain21882294
    nsv528460CNV Gain19592680
    esv7629CNV Gain19470904
    dgv12e55CNV Gain17911159
    essv19099CNV CNV17122850
    esv743CNV CNV17122850

    Human Gene Mutation Database (HGMD): F13B
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134580   
    OMIM disorders: 613235  
    UniProtKB/Swiss-Prot: F13B_HUMAN, P05160
  • Factor XIII subunit B deficiency (FA13BD) [MIM:613235]: An autosomal recessive hematologic disorder
    characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected
    women. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for F13B (see all 30):    
    About MalaCards
    factor xiii subunit b deficiency    factor xiiib deficiency    factor xiii deficiency    factor xiiia deficiency
    varicose veins    hemarthrosis    disseminated intravascular coagulation    dengue hemorrhagic fever
    pregnancy loss    hemorrhagic fever    venous thrombosis    age related macular degeneration
    septic shock    vascular disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    crohn's disease    sepsis    type 1 diabetes    myocardial infarction

    2 diseases from the University of Copenhagen DISEASES database for F13B:
    Factor XIII deficiency     Hemarthrosis

    F13B for disorders           About GeneDecksing

    Genatlas disease: F13B
    bleeding tendency,defective wound healing, habitual abortion,fibrin-stabilizing factor deficiency,type I

    Genetic Association Database (GAD): F13B
    Human Genome Epidemiology (HuGE) Navigator: F13B (22 documents)

    Export disorders for F13B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for F13B gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with F13B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of the gene for the b subunit of human factor XIII. (PubMed id 2271707)1, 2, 3 Bottenus R.E.... Davie E.W. (Biochemistry 1990)
    2. Complete cDNA sequence encoding the B subunit of human factor XIII. (PubMed id 2339067)1, 2, 3 Grundmann U.... Zettlmeissl G. (Nucleic Acids Res. 1990)
    3. A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis. (PubMed id 16241947)1, 4, 9 Komanasin N....AriAns R.A. (J. Thromb. Haemost. 2005)
    4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    6. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. Genes influencing coagulation and the risk of aneurysmal subarachnoid hemorrhage, and subsequent complications of secondary cerebral ischemia and rebleeding. (PubMed id 19826759)1, 4 Ruigrok Y.M....Rosendaal F.R. (Acta Neurochir (Wien) 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Genetic variants of coagulation factor XIII and the risk of myocardial infarction in young women. (PubMed id 19604232)1, 4 Siegerink B....Rosendaal F.R. (Br. J. Haematol. 2009)
    10. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2165 HGNC: 3534 AceView: F13B Ensembl:ENSG00000143278 euGenes: HUgn2165
    ECgene: F13B Kegg: 2165 H-InvDB: F13B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for F13B Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=F&genename=F13B+%40+FXIIIB
    Wikipedia http://en.wikipedia.org/wiki/Factor_XIII
    SeattleSNPshttp://pga.gs.washington.edu/data/f13b/

    (Patent information from GeneIP,
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    Patent Information for F13B gene:
    Search GeneIP for patents involving F13B

    GeneCards and IP:
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