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Aliases & Descriptions for F13B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FXIIIB 1, 2 | | OTTHUMP00000034674 2 | | TGase 2 |
| | | Descriptions |
|---|
| Fibrin-stabilizing factor B subunit 3 | | Protein-glutamine gamma-glutamyltransferase B chain 3 | | Transglutaminase B chain 3 | | coagulation factor XIII B subunit 2 | | coagulation factor XIII, B polypeptide 2 |
|
| | Search outside databases for aliases for F13B genePrevious GC identifers: GC01M194735 GC01M192466 GC01M193474 GC01M194296 GC01M193739 |
Summaries for F13B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for F13B: This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq] UniProtKB/Swiss-Prot: F13B_HUMAN, P05160Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombinGene Wiki entry for F13B |
Genomic Location for F13B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the F13B gene 
Entrez Gene cytogenetic band: 1q31-q32.1 Ensembl cytogenetic band: 1q31.3 HGNC cytogenetic band: 1q31-q32.1F13B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M195274:
(about GC identifiers)
Start:
|
195,274,944 bp from pter |
End:
|
195,303,020 bp from pter |
Size:
|
28,077 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for F13B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: F13B_HUMAN, P05160 (See
protein sequence)Recommended Name: Coagulation factor XIII B chain precursor Size: 661 amino acids; 75511 Da
Subunit: Tetramer of two A chains and two B chains
Secondary accessions: A8K3E5 Q5VYL5REFSEQ proteins: NP_001985.2
ENSEMBL proteins: ENSP00000356382
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for F13B: Assays for F13B: | Protein
Domains/ Families for F13B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P05160
ProtoNet protein and cluster: P05160 1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160Similarity: Contains 10 Sushi (CCP/SCR) domains | Gene Function for F13B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001994
Applied Biosystems Silencer® siRNAs for F13B
Sigma-Aldrich siRNA for F13B  Sigma-Aldrich shRNA for F13B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001994                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001994                                  untagged cDNA clone in CMV expression vector: NM_001994 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001994
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombinGenatlas biochemistry entry for F13B:coagulation factor XIII,B polypeptide,non catalytic (80kDa) | Pathways & Interactions for F13B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for F13B (Your Favorite Gene powered by Ingenuity) 
5/17 Interacting proteins for F13B (ENSP000003563823) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for F13B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for F13B
|
Transcripts for F13B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001994
Sigma-Aldrich siRNA for F13B  Sigma-Aldrich shRNA for F13B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001994 REFSEQ mRNAs for F13B gene: NM_001994.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001994               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001994                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001994                                  untagged cDNA clone in CMV expression vector: NM_001994  Additional cDNA sequence: AK290560.1 M14057.1 2 DOTS entries: DT.205660 DT.40130708 8 AceView cDNA sequences:R28976 BG565816 M14057 BV183392 BX510295 NM_001994 BG200902 BV178758
highest scoring ESTs for F13B:AV653108 AV659008 AV659833 M14057 AV659626 BG200902 BG565816 BX510295 NM_001994 R28976 Unigene Cluster for F13B: Coagulation factor XIII, B polypeptide Hs.435782 [show with all ESTs]Unigene Representative Sequence: NM_001994
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000367412
|
Expression for F13B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| F13B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for F13B
1 / 2 / 3 3 probe-sets matching F13B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.435782
Expression variation in blood from EXPOLDB for F13B |
Orthologs for F13B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for F13B gene from 5/6 species (see all 6
)
About this table Species with no ortholog for F13B
ENSEMBL Gene Tree for F13B | Paralogs for F13B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for F13B gene
- CFHR42 CFHR22 CFHR52 CFHR32 CFH2 CFHR12
|
SNPs/Variants for F13B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for F13B (up to first 250kb)
|
Disorders & Mutations for F13B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 134580 UniProtKB/Swiss-Prot: F13B_HUMAN, P05160
Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortionGenatlas disease: F13B bleeding tendency,defective wound healing, habitual abortion,fibrin-stabilizing factor deficiency,type I Human Gene Mutation Database: F13B Genetic Association Database: F13B Human Genome Epidemiology Navigator: F13B (9 documents)
|
Medical News for F13B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for F13B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/55 PubMed articles for F13B gene (see all 55
):- Nucleotide sequence of the gene for the b subunit of human factor XIII. (PubMed id 2271707)2, 3, 4 Bottenus R.E....Davie E.W. (1990)
- Complete cDNA sequence encoding the B subunit of human factor XIII. (PubMed id 2339067)2, 3, 4 Grundmann U.... Zettlmeissl G. (1990)
- A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis. (PubMed id 16241947)1, 3, 6 Komanasin N....Ariens R.A. (2005)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction. (PubMed id 12456499)3, 6 Reiner A.P....Psaty B.M. (2003)
- Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)3, 4 Cargill M....Lander E.S. (1999)
- Two genetic defects in a patient with complete deficiency of the b- subunit for coagulation factor XIII. (PubMed id 8324218)3, 4 Hashiguchi T.... Ichinose A. (1993)
- Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments. (PubMed id 3021194)3, 4 Ichinose A.... Davie E.W. (1986)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)4 Chen R.... Zou H. (2009)
|
Search for F13B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing F13B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing F13B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing F13B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=F&genename=F13B+%40+FXIIIB | | Wikipedia | http://en.wikipedia.org/wiki/Factor_XIII | | SeattleSNPs | http://pga.gs.washington.edu/data/f13b/ |
|
| | | About This Section
| --
| Services for F13B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for F13B:

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Incremental update: 13 Oct 2009
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