F13B Gene
protein-coding GIFtS: 59
GCID: GC01M197008
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coagulation factor XIII, B polypeptide
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Aliases
for F13B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coagulation Factor XIII, B Polypeptide1 2 | | Transglutaminase B Chain2 3 | | FXIIIB1 2 | | TGase2 | | Fibrin-Stabilizing Factor B Subunit2 3 | | Coagulation Factor XIII B Chain2 | | Protein-Glutamine Gamma-Glutamyltransferase B Chain2 3 | | |
Export aliases for F13B gene to outside databasesPrevious GC identifers: GC01M194735 GC01M192466 GC01M193474 GC01M194296 GC01M193739 GC01M195274 GC01M168165 |
Summaries
for F13B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for F13B:
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated inthe blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The Asubunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carriermolecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Uponactivation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factorXIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzymeacts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrinmolecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type Ideficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lackof the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, andhabitual abortion. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits andregulate the rate of transglutaminase formation by thrombin
Gene Wiki entry for F13B
|
Genomic Views
for F13B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the F13B gene promoter:
Pbx1a Pax-5 HNF-4alpha2 HNF-4alpha1 POU2F1 POU2F1a POU2F1b POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for F13B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F13B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q31-q32.1 Ensembl cytogenetic band: 1q31.3 HGNC cytogenetic band: 1q31-q32.1F13B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M197008: view genomic region
(about GC identifiers)
Start:
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197,008,321 bp from pter |
End:
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197,036,397 bp from pter |
Size:
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28,077 bases |
Orientation:
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minus strand |
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Proteins
for F13B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160 (See
protein sequence)Recommended Name: Coagulation factor XIII B chain precursor Size: 661 amino acids; 75511 Da
Subunit: Tetramer of two A chains and two B chains
Subcellular location: Secreted
Secondary accessions: A8K3E5 Q5VYL5Explore the universe of human proteins at neXtProt for F13B: NX_P05160
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P05160
F13B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001985.2
ENSEMBL proteins: ENSP00000356382 Reactome Protein details: P05160
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
F13B for ontologies About GeneDecksing
F13B Antibody Products:
Assay Products for F13B: |
Protein
Domains /
Families
for F13B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
F13B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P05160ProtoNet protein and cluster: P05160 1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160Similarity: Contains 10 Sushi (CCP/SCR) domains |
Function
for F13B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits andregulate the rate of transglutaminase formation by thrombin Genatlas biochemistry entry for F13B:coagulation factor XIII,B polypeptide,non catalytic (80kDa)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F13B |
2 GenomeRNAi human phenotypes for F13B:
|
Pathways & Interactions
for F13B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Blood Coagulation Cascade | | | 2 | Formation of Fibrin Clot (Clotting Cascade) | | | 3 | Complement and coagulation cascades | | | 4 | Common Pathway | | | 5 | Selected targets of HNF1 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for F13B
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for F13B
3  BioSystems Pathways for F13B
3 
Reactome Pathways for F13B
1 
Kegg Pathway (Kegg details for F13B):
F13B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for F13B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for F13B (P051603 ENSP000003563824) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007596 | blood coagulation |
TAS | -- |
F13B for ontologies About GeneDecksing
|
Drugs & Compounds
for F13B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for F13B
Search CenterWatch for drugs/clinical trials and news about F13B
|
Transcripts
for F13B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for F13B gene: NM_001994.2 Unigene Cluster for F13B: Coagulation factor XIII, B polypeptide Hs.435782 [show with all ESTs]Unigene Representative Sequence: NM_0019942 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367412(uc001gtt.1) ENST00000490002
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for F13B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for F13B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: F13B (NM_001994) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for F13B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F13B |
Additional cDNA sequence: AK290560.1 M14057.1 2 DOTS entries: DT.205660 DT.40130708 8 AceView cDNA sequences: R28976 BG200902 BV183392 BX510295 BG565816 NM_001994 BV178758 M14057
GeneLoc Exon Structure
|
Expression
for F13B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| F13B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See F13B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for F13B
SOURCE GeneReport for Unigene cluster: Hs.435782
SABiosciences Custom PCR Arrays for F13B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for F13B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F13B |
Orthologs
for F13B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for F13B gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for F13B (if available)
TreeFam Gene Tree for F13B (if available) |
Paralogs
for F13B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for F13B gene
- CFHR42 APOH2 CFHR52 CFHR22 CFH2 CFHR32 CFHR12
F13B for paralogs About GeneDecksing
|
Genomic Variants
for F13B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for F13B (197008321 - 197036397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for F13B
3 CNVs: 8343 2343 3326
1 Indel: 59972
Human Gene Mutation Database (HGMD): F13B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing F13B |
|
Disorders
/ Diseases
for F13B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
F13B for disorders About GeneDecksing
OMIM gene information: 134580
OMIM disorders: 613235
UniProtKB/Swiss-Prot: F13B_HUMAN, P05160
Defects in F13B are the cause of factor XIII subunit B deficiency (FA13BD) [MIM:613235]. FA13BD is anautosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneousabortion in affected women
20/22  diseases for F13B (see all 22): About MalaCardsfactor xiii deficiency factor xiii subunit b deficiency habitual abortion factor xiiib deficiency
disseminated intravascular coagulation age related macular degeneration dengue hemorrhagic fever hemorrhagic fever
macular degeneration spontaneous abortion hemarthrosis myocardial infarction
vascular disease hepatitis b thrombosis ischemia
atherosclerosis hepatitis cerebritis venous thrombosis
2 diseases from the University of Copenhagen DISEASES database for F13B:Factor XIII deficiency Hemarthrosis Genatlas disease: F13B bleeding tendency,defective wound healing, habitual abortion,fibrin-stabilizing factor deficiency,type I
Genetic Association Database (GAD): F13B
Human Genome Epidemiology (HuGE) Navigator: F13B (22 documents)
Export disorders for F13B gene to outside databases
|
Publications
for F13B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for F13B gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with F13B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nucleotide sequence of the gene for the b subunit of human factor XIII. (PubMed id 2271707)1, 2, 3 Bottenus R.E....Davie E.W. (1990)
- Complete cDNA sequence encoding the B subunit of human factor XIII. (PubMed id 2339067)1, 2, 3 Grundmann U.... Zettlmeissl G. (1990)
- A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis. (PubMed id 16241947)1, 4, 9 Komanasin N....Ariens R.A. (2005)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction. (PubMed id 12456499)1, 4 Reiner A.P....Psaty B.M. (2003)
- Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation. (PubMed id 11313256)1, 2 Koseki S....Shitishima T. (2001)
- Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (1999)
- Two genetic defects in a patient with complete deficiency of the b- subunit for coagulation factor XIII. (PubMed id 8324218)1, 2 Hashiguchi T.... Ichinose A. (1993)
- Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments. (PubMed id 3021194)1, 2 Ichinose A.... Davie E.W. (1986)
|
External Searches for F13B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing F13B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing F13B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing F13B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for F13B | Pharmacogenomics, SNPs, Pathways | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=F&genename=F13B+%40+FXIIIB | | Wikipedia | http://en.wikipedia.org/wiki/Factor_XIII | | SeattleSNPs | http://pga.gs.washington.edu/data/f13b/ |
|
| | |
About This Section
| Patent Information for F13B gene:
Search GeneIP for patents involving F13B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for F13B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat F13B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing F13B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat F13B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat F13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat F13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat F13B |
| |
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 | | | F13B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for F13B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat F13B |
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